CL2021001116A1 - Nuevas urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (hbv) - Google Patents

Nuevas urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (hbv)

Info

Publication number
CL2021001116A1
CL2021001116A1 CL2021001116A CL2021001116A CL2021001116A1 CL 2021001116 A1 CL2021001116 A1 CL 2021001116A1 CL 2021001116 A CL2021001116 A CL 2021001116A CL 2021001116 A CL2021001116 A CL 2021001116A CL 2021001116 A1 CL2021001116 A1 CL 2021001116A1
Authority
CL
Chile
Prior art keywords
hbv
virus
pyrazines
pyrazolo
dihydro
Prior art date
Application number
CL2021001116A
Other languages
English (en)
Inventor
Alastair Donald
Andreas Urban
Susanne Bonsmann
Original Assignee
Aicuris Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg
Publication of CL2021001116A1 publication Critical patent/CL2021001116A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere, en general, a nuevos agentes antivíricos. Específicamente, la presente invención se refiere a compuestos que pueden inhibir la proteína o proteínas codificada(s) por el virus de la hepatitis B (VHB) o interferir con la función del ciclo de replicación del VHB, a composiciones que comprenden dichos compuestos, a métodos para inhibir la replicación del virus VHB, a métodos para tratar o prevenir la infección por VHB y a procesos o intermedios para fabricar los compuestos.
CL2021001116A 2018-11-02 2021-04-29 Nuevas urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (hbv) CL2021001116A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18000877 2018-11-02

Publications (1)

Publication Number Publication Date
CL2021001116A1 true CL2021001116A1 (es) 2021-11-05

Family

ID=64362287

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2021001116A CL2021001116A1 (es) 2018-11-02 2021-04-29 Nuevas urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (hbv)

Country Status (19)

Country Link
US (1) US20210355129A1 (es)
EP (1) EP3873908A1 (es)
JP (1) JP2022512870A (es)
KR (1) KR20210098986A (es)
CN (1) CN113039186A (es)
AR (1) AR117188A1 (es)
AU (1) AU2019370735A1 (es)
BR (1) BR112021008360A2 (es)
CA (1) CA3118387A1 (es)
CL (1) CL2021001116A1 (es)
CU (1) CU20210037A7 (es)
EA (1) EA202191219A1 (es)
EC (1) ECSP21031082A (es)
IL (1) IL282587A (es)
MX (1) MX2021004987A (es)
SG (1) SG11202104126UA (es)
TW (1) TW202031662A (es)
UY (1) UY38437A (es)
WO (1) WO2020089459A1 (es)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11673894B2 (en) 2018-02-27 2023-06-13 Incyte Corporation Imidazopyrimidines and triazolopyrimidines as A2A / A2B inhibitors
US11873304B2 (en) 2018-05-18 2024-01-16 Incyte Corporation Fused pyrimidine derivatives as A2A/A2B inhibitors
US11884665B2 (en) 2019-01-29 2024-01-30 Incyte Corporation Pyrazolopyridines and triazolopyridines as A2A / A2B inhibitors

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* Cited by examiner, † Cited by third party
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AR116947A1 (es) * 2018-11-02 2021-06-30 Aicuris Gmbh & Co Kg Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas-indol-2-carboxamidas activas contra el virus de la hepatitis b (vhb)
UY38434A (es) * 2018-11-02 2020-05-29 Aicuris Gmbh & Co Kg Nuevas 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activas contra el virus de la hepatitis b (hbv)
JP2022531199A (ja) * 2019-04-30 2022-07-06 アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト Ｂ型肝炎ウイルス（ｈｂｖ）に対し活性な新規のフェニル及びピリジル尿素

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11673894B2 (en) 2018-02-27 2023-06-13 Incyte Corporation Imidazopyrimidines and triazolopyrimidines as A2A / A2B inhibitors
US11873304B2 (en) 2018-05-18 2024-01-16 Incyte Corporation Fused pyrimidine derivatives as A2A/A2B inhibitors
US11884665B2 (en) 2019-01-29 2024-01-30 Incyte Corporation Pyrazolopyridines and triazolopyridines as A2A / A2B inhibitors

Also Published As

Publication number Publication date
MX2021004987A (es) 2021-06-15
CU20210037A7 (es) 2021-12-08
BR112021008360A2 (pt) 2021-08-03
IL282587A (en) 2021-06-30
AR117188A1 (es) 2021-07-21
UY38437A (es) 2020-05-29
CA3118387A1 (en) 2020-05-07
KR20210098986A (ko) 2021-08-11
AU2019370735A1 (en) 2021-05-27
TW202031662A (zh) 2020-09-01
WO2020089459A1 (en) 2020-05-07
US20210355129A1 (en) 2021-11-18
SG11202104126UA (en) 2021-05-28
CN113039186A (zh) 2021-06-25
JP2022512870A (ja) 2022-02-07
EA202191219A1 (ru) 2021-07-28
ECSP21031082A (es) 2021-05-31
EP3873908A1 (en) 2021-09-08

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