AR116947A1 - Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas-indol-2-carboxamidas activas contra el virus de la hepatitis b (vhb) - Google Patents

Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas-indol-2-carboxamidas activas contra el virus de la hepatitis b (vhb)

Info

Publication number
AR116947A1
AR116947A1 ARP190103180A ARP190103180A AR116947A1 AR 116947 A1 AR116947 A1 AR 116947A1 AR P190103180 A ARP190103180 A AR P190103180A AR P190103180 A ARP190103180 A AR P190103180A AR 116947 A1 AR116947 A1 AR 116947A1
Authority
AR
Argentina
Prior art keywords
pirazinas
carboxamidas
pirazolo
dihidro
hbv
Prior art date
Application number
ARP190103180A
Other languages
English (en)
Inventor
Anita Wegert
Jasper Springer
Susanne Bonsmann
Andreas Urban
Alastair Donald
Original Assignee
Aicuris Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg
Publication of AR116947A1 publication Critical patent/AR116947A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Reivindicación 1: Un compuesto de fórmula (1) en donde R¹, R², R³ y R⁴ se seleccionan, para cada posición, independientemente del grupo que comprende H, CF₂H, CF₃, CF₂CH₃, F, Cl, Br, CH₃, Et, i-Pr, c-Pr, D, CH₂OH, CH(CH₃)OH, CH₂F, CH(F)CH₃, I, C=C, C&
ARP190103180A 2018-11-02 2019-10-31 Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas-indol-2-carboxamidas activas contra el virus de la hepatitis b (vhb) AR116947A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18000876 2018-11-02

Publications (1)

Publication Number Publication Date
AR116947A1 true AR116947A1 (es) 2021-06-30

Family

ID=64362286

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP190103180A AR116947A1 (es) 2018-11-02 2019-10-31 Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas-indol-2-carboxamidas activas contra el virus de la hepatitis b (vhb)

Country Status (20)

Country Link
US (1) US20220363686A1 (es)
EP (1) EP3873909A1 (es)
JP (1) JP2022512871A (es)
KR (1) KR20210099562A (es)
CN (1) CN113056467A (es)
AR (1) AR116947A1 (es)
AU (1) AU2019370994A1 (es)
BR (1) BR112021008361A2 (es)
CA (1) CA3118380A1 (es)
CL (1) CL2021001117A1 (es)
CU (1) CU20210038A7 (es)
EA (1) EA202191216A1 (es)
EC (1) ECSP21031085A (es)
IL (1) IL282480A (es)
MX (1) MX2021004986A (es)
PH (1) PH12021550979A1 (es)
SG (1) SG11202104130SA (es)
TW (1) TW202031661A (es)
UY (1) UY38436A (es)
WO (1) WO2020089453A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR117189A1 (es) * 2018-11-02 2021-07-21 Aicuris Gmbh & Co Kg Derivados de 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activos contra el virus de la hepatitis b (vhb)
UY38437A (es) * 2018-11-02 2020-05-29 Aicuris Gmbh & Co Kg Nuevas urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (hbv)
JP2023513272A (ja) 2020-02-07 2023-03-30 ガシャーブラム・バイオ・インコーポレイテッド ヘテロ環ｇｌｐ－１アゴニスト
CN116368140A (zh) * 2020-09-10 2023-06-30 加舒布鲁姆生物公司 杂环glp-1激动剂

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19817264A1 (de) 1998-04-18 1999-10-21 Bayer Ag Neue Dihydropyrimidine
AU4289100A (en) 1999-03-25 2000-10-16 Bayer Aktiengesellschaft Dihydropyrimidines and their use in the treatment of hepatitis
AU768560B2 (en) 1999-04-23 2003-12-18 Extenday Ip Limited Sheet fastening and anchoring component
AU3009801A (en) 1999-12-22 2001-07-03 Bayer Aktiengesellschaft Combinations of medicaments for treating viral diseases
WO2006033995A2 (en) 2004-09-16 2006-03-30 Valeant Research And Development Thiazolidin-4-ones having anti-hepatitis b activity
US7943617B2 (en) * 2006-11-27 2011-05-17 Bristol-Myers Squibb Company Heterobicyclic compounds useful as kinase inhibitors
EP3085368A1 (en) 2011-07-01 2016-10-26 Baruch S. Blumberg Institute Sulfamoylbenzamide derivatives as antiviral agents against hbv infection
US8629274B2 (en) 2011-12-21 2014-01-14 Novira Therapeutics, Inc. Hepatitis B antiviral agents
EP2800742B1 (en) 2012-01-06 2016-04-06 Janssen Sciences Ireland UC 4,4-disubstituted-1,4-dihydropyrimidines and the use thereof as medicaments for the treatment of hepatitis b
US9096579B2 (en) * 2012-04-20 2015-08-04 Boehringer Ingelheim International Gmbh Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments
UY34993A (es) 2012-08-28 2014-02-28 Janssen R & D Ireland Sulfamoilarilamidas y su uso como medicamentos para el tratamiento de la hepatitis b
BR112015004161B8 (pt) 2012-08-28 2022-11-08 Janssen Sciences Ireland Uc Derivado bicíclico fusionado de sulfamoíla e seu uso no tratamento e prevenção de infecção por vírus da hepatite b, bem como composição farmacêutica e produto que o compreende
US8993771B2 (en) 2013-03-12 2015-03-31 Novira Therapeutics, Inc. Hepatitis B antiviral agents
JP6533217B2 (ja) 2013-05-17 2019-06-19 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｂ型肝炎ウイルス感染症の治療および予防のための６−架橋ヘテロアリールジヒドロピリミジン類
LT2997019T (lt) 2013-05-17 2018-11-26 Janssen Sciences Ireland Uc Sulfamoiltiofenamido dariniai ir jų panaudojimas kaip vaistų hepatito b gydymui
SG11201600522UA (en) 2013-07-25 2016-02-26 Janssen Sciences Ireland Uc Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
CA2927560A1 (en) 2013-10-18 2015-04-23 Indiana University Research And Technology Corporation Hepatitis b viral assembly effectors
KR20160127714A (ko) 2013-11-14 2016-11-04 노비라 테라퓨틱스, 인코포레이티드 아제판 유도체 및 b형 간염 감염의 치료 방법
US9169212B2 (en) 2014-01-16 2015-10-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
HUE041734T2 (hu) 2014-03-07 2019-05-28 Hoffmann La Roche Új, 6-tagú gyûrûvel kondenzált heteroarildihidropirimidinek hepatitisz B vírusfertõzés kezelésére és megelõzésére
US10183936B2 (en) 2014-03-13 2019-01-22 Indiana University Research And Technology Corporation Hepatitis B core protein allosteric modulators
KR20160133563A (ko) 2014-03-28 2016-11-22 선샤인 레이크 파르마 컴퍼니 리미티드 다이하이드로피리미딘 화합물 및 이의 약제학적 용도
AU2015255656A1 (en) 2014-05-09 2016-11-10 Assembly Biosciences, Inc. Methods and compositions for treating hepatitis B virus infections
RU2664329C1 (ru) 2014-08-14 2018-08-16 Ф. Хоффманн-Ля Рош Аг Новые пиридазоны и триазиноны для лечения и профилактики заражения вирусом гепатита b
AU2015358561A1 (en) 2014-12-02 2017-06-08 Novira Therapeutics, Inc. Sulfide alkyl and pyridyl reverse sulfonamide compounds for HBV treatment
KR20170118706A (ko) 2014-12-30 2017-10-25 노비라 테라퓨틱스, 인코포레이티드 B형 간염 감염을 치료하는 유도체 및 그 방법
MA41338B1 (fr) 2015-01-16 2019-07-31 Hoffmann La Roche Composés de pyrazine pour le traitement de maladies infectieuses
KR102139708B1 (ko) 2015-03-16 2020-07-31 에프. 호프만-라 로슈 아게 Tlr7 작용제 및 hbv 캡시드 조립 억제제를 사용하는 병용 치료
US10442788B2 (en) 2015-04-01 2019-10-15 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
EP3292120B1 (en) 2015-05-04 2019-06-19 H. Hoffnabb-La Roche Ag Tetrahydropyridopyrimidines and tetrahydropyridopyridines as inhibitors of hbsag (hbv surface antigen) and hbv dna production for the treatment of hepatitis b virus infections
US10738035B2 (en) 2015-05-13 2020-08-11 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US10875876B2 (en) 2015-07-02 2020-12-29 Janssen Sciences Ireland Uc Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
WO2017011552A1 (en) 2015-07-13 2017-01-19 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
WO2017013046A1 (en) 2015-07-21 2017-01-26 F. Hoffmann-La Roche Ag Novel tricyclic 4-pyridone-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection
WO2017015451A1 (en) 2015-07-22 2017-01-26 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
TWI721016B (zh) 2015-09-15 2021-03-11 美商艾森伯利生物科學公司 B型肝炎核心蛋白質調節劑
AR106192A1 (es) 2015-09-29 2017-12-20 Novira Therapeutics Inc Formas cristalinas de un agente antiviral contra la hepatitis b
EP3372606B1 (en) 2015-11-04 2020-04-08 Qilu Pharmaceutical Co., Ltd Crystal form, preparation method and intermediate of dihydropyrido ring compound
WO2017136403A1 (en) 2016-02-02 2017-08-10 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
EP3426245B1 (en) 2016-03-07 2022-12-14 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
WO2017198744A1 (en) 2016-05-20 2017-11-23 F. Hoffmann-La Roche Ag Novel pyrazine compounds with oxygen, sulfur and nitrogen linker for the treatment of infectious diseases
JP7034133B2 (ja) 2016-07-14 2022-03-11 エフ．ホフマン－ラ ロシュ アーゲー 感染性疾患の処置のためのカルボキシ ６，７－ジヒドロ－４Ｈ－ピラゾロ［１，５－ａ］ピラジン化合物
WO2018011160A1 (en) 2016-07-14 2018-01-18 F. Hoffmann-La Roche Ag 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazine compounds for the treatment of infectious diseases
JP7051804B2 (ja) 2016-07-14 2022-04-11 エフ．ホフマン－ラ ロシュ アーゲー 感染症の治療のための６，７－ジヒドロ－４Ｈ－ピラゾロ［１，５－ａ］ピラジン化合物と６，７－ジヒドロ－４Ｈ－トリアゾロ［１，５－ａ］ピラジン化合物
JOP20190024A1 (ar) 2016-08-26 2019-02-19 Gilead Sciences Inc مركبات بيروليزين بها استبدال واستخداماتها
CA3036245C (en) 2016-09-13 2021-07-20 Arbutus Biopharma Corporation Substituted chromane-8-carboxamide compounds and analogues thereof, and methods using same
SG11201908012SA (en) 2017-03-02 2019-09-27 Assembly Biosciences Inc Cyclic sulfamide compounds and methods of using same
AU2018238138A1 (en) 2017-03-21 2019-10-17 Arbutus Biopharma Corporation Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same
CA3070004A1 (en) * 2017-07-27 2019-01-31 Jiangsu Hengrui Medicine Co., Ltd. Piperazine heteroaryl derivative, preparation method therefor and use of same in medicine
TW201925199A (zh) * 2017-11-02 2019-07-01 德商艾庫瑞斯公司 對b型肝炎病毒(hbv)具有活性的新穎高活性吡唑并哌啶取代的吲哚-2-甲醯胺
CA3081386A1 (en) * 2017-11-02 2019-05-09 Aicuris Gmbh & Co. Kg Highly active amino-thiazole substituted indole-2-carboxamides active against the hepatitis b virus (hbv)
EP3759110A1 (en) * 2018-02-28 2021-01-06 Novartis AG Indole-2-carbonyl compounds and their use for the treatment of hepatitis b
UY38437A (es) * 2018-11-02 2020-05-29 Aicuris Gmbh & Co Kg Nuevas urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (hbv)
AR117189A1 (es) * 2018-11-02 2021-07-21 Aicuris Gmbh & Co Kg Derivados de 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activos contra el virus de la hepatitis b (vhb)

Also Published As

Publication number Publication date
PH12021550979A1 (en) 2021-11-22
KR20210099562A (ko) 2021-08-12
CL2021001117A1 (es) 2021-11-05
TW202031661A (zh) 2020-09-01
US20220363686A1 (en) 2022-11-17
EP3873909A1 (en) 2021-09-08
JP2022512871A (ja) 2022-02-07
CU20210038A7 (es) 2021-12-08
UY38436A (es) 2020-05-29
IL282480A (en) 2021-06-30
MX2021004986A (es) 2021-06-15
CA3118380A1 (en) 2020-05-07
CN113056467A (zh) 2021-06-29
WO2020089453A1 (en) 2020-05-07
EA202191216A1 (ru) 2021-08-03
BR112021008361A2 (pt) 2021-08-03
ECSP21031085A (es) 2021-05-31
AU2019370994A1 (en) 2021-05-27
SG11202104130SA (en) 2021-05-28

Similar Documents

Publication Publication Date Title
AR117189A1 (es) Derivados de 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activos contra el virus de la hepatitis b (vhb)
AR116947A1 (es) Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas-indol-2-carboxamidas activas contra el virus de la hepatitis b (vhb)
AR092876A1 (es) Inhibidores no nucleosidos de la transcriptasa inversa
AR115131A1 (es) Altamente activas indolo-2-carboxamidas sustituidas con pirazolo-pirimidina activas contra el virus de la hepatitis b (vhb)
UY37927A (es) Proceso para la preparación de 6-(2-hidroxi-2-metilpropoxi)-4-(6-(6-((6-metoxipiridin-3-il)metil)-3,6-diazabiciclo[3.1.1]heptan-3-il)piridin-3-il)pirazolo[1,5-a]piridina-3-carbonitrilo
PE20230376A1 (es) Compuestos moduladores de la diacilglicerol quinasa
RS53843B1 (en) BIS (FLUOROALKYL) -1,4-BENZODIAZEPINONE COMPOUNDS
AR099379A1 (es) Compuestos tricíclicos como agentes antineoplásicos
EA201690019A1 (ru) Производное аминотриазина и содержащая его фармацевтическая композиция
EA201591457A8 (ru) Терапевтические соединения
AR088175A1 (es) 3-pirimidin-4-il-oxazolidin-2-onas utiles para tratar cancer y composiciones farmaceuticas que las contienen
AR089671A1 (es) 1,4-dihidropirimidinas 4,4-disustituidas y su uso como medicamentos para el tratamiento de la hepatitis b
AR113826A1 (es) Indol-2-carboxamidas sustituidas con amino-tiazol activas contra el virus de la hepatitis b (vhb)
JP2016506960A5 (es)
AR085203A1 (es) Inhibidores benzimidazol del virus sincitial respiratorio
AR101815A1 (es) Compuestos y composiciones como inhibidores de quinasa
AR103412A1 (es) Derivados de indol mono o disustituido como inhibidores de la replicación del virus del dengue
AR097082A1 (es) Compuestos terapéuticamente activos y sus métodos de uso
AR112333A1 (es) Pirrolopirimidina y derivados de pirrolopirimidina
PE20212325A1 (es) Derivados de pirimidona de anillo fusionado para uso en el tratamiento de infeccion por vhb o enfermedades inducidas por vhb
AR101696A1 (es) Compuestos de azetidiniloxifenilpirrolidina
EA201891239A1 (ru) 1,3,4-тиадиазольные соединения и их применение в лечении рака
AR116948A1 (es) Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (vhb)
AR106475A1 (es) Derivados de piridina o de pirimidina
RU2017110512A (ru) Противовирусные агенты и их применение