AR101696A1 - Compuestos de azetidiniloxifenilpirrolidina - Google Patents

Compuestos de azetidiniloxifenilpirrolidina

Info

Publication number
AR101696A1
AR101696A1 ARP150102734A ARP150102734A AR101696A1 AR 101696 A1 AR101696 A1 AR 101696A1 AR P150102734 A ARP150102734 A AR P150102734A AR P150102734 A ARP150102734 A AR P150102734A AR 101696 A1 AR101696 A1 AR 101696A1
Authority
AR
Argentina
Prior art keywords
compounds
formula
azetidinyloxyphenylpirrolidine
compound
formulas
Prior art date
Application number
ARP150102734A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54140711&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR101696(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR101696A1 publication Critical patent/AR101696A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La solicitud proporciona determinados compuestos de azetidiniloxifenilpirrolidina, particularmente compuestos de la fórmula (1), y composiciones farmacéuticas de estos. Proporciona además métodos para usar un compuesto de la fórmula (1) para tratar la vejiga hiperactiva. Reivindicación 1: Un compuesto de la fórmula (1) donde R es un resto seleccionado del grupo de fórmulas (2), R¹ es CH₃, CD₃, CN, Cl o CF₃; siempre que R¹ es CH₃ este no se une en la posición 5; o una sal farmacéuticamente aceptable de este.
ARP150102734A 2014-09-12 2015-08-26 Compuestos de azetidiniloxifenilpirrolidina AR101696A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462049485P 2014-09-12 2014-09-12

Publications (1)

Publication Number Publication Date
AR101696A1 true AR101696A1 (es) 2017-01-04

Family

ID=54140711

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150102734A AR101696A1 (es) 2014-09-12 2015-08-26 Compuestos de azetidiniloxifenilpirrolidina

Country Status (34)

Country Link
US (2) US10781202B2 (es)
EP (1) EP3191466B1 (es)
JP (1) JP6285610B2 (es)
KR (1) KR101857931B1 (es)
CN (1) CN106795137B (es)
AP (1) AP2017009778A0 (es)
AR (1) AR101696A1 (es)
AU (1) AU2015315533B2 (es)
BR (1) BR112017002852A2 (es)
CA (1) CA2955634A1 (es)
CL (1) CL2017000484A1 (es)
CO (1) CO2017001389A2 (es)
CR (1) CR20170050A (es)
DK (1) DK3191466T3 (es)
EA (1) EA030034B1 (es)
EC (1) ECSP17014972A (es)
ES (1) ES2770047T3 (es)
HR (1) HRP20200119T1 (es)
HU (1) HUE047551T2 (es)
IL (1) IL250378A0 (es)
LT (1) LT3191466T (es)
MX (1) MX2017003138A (es)
NZ (1) NZ729087A (es)
PE (1) PE20170328A1 (es)
PH (1) PH12017500459A1 (es)
PL (1) PL3191466T3 (es)
PT (1) PT3191466T (es)
RS (1) RS59845B1 (es)
SG (1) SG11201701225YA (es)
SI (1) SI3191466T1 (es)
TN (1) TN2017000047A1 (es)
TW (1) TW201625591A (es)
WO (1) WO2016040083A1 (es)
ZA (1) ZA201700555B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2845473T3 (es) 2013-03-14 2021-07-26 Boehringer Ingelheim Int (Bencil-ciano-metil)-amidas sustituidas de ácido 2-aza-biciclo[2.2.1]heptano-3-carboxílico inhibidores de la catepsina- C
DK3191487T3 (da) 2014-09-12 2019-10-28 Boehringer Ingelheim Int Spirocykliske cathepsin-c-inhibitorer
WO2020125627A1 (zh) 2018-12-18 2020-06-25 湖北生物医药产业技术研究院有限公司 苯基吡咯烷类化合物及其用途
CN111333625B (zh) * 2018-12-18 2022-10-18 武汉人福创新药物研发中心有限公司 苯基吡咯烷类化合物及其用途
CN111333637B (zh) * 2018-12-18 2022-07-29 武汉人福创新药物研发中心有限公司 苯基吡咯烷类衍生物及其制备方法
WO2021036953A1 (zh) * 2019-08-23 2021-03-04 湖北生物医药产业技术研究院有限公司 苯基吡咯烷类化合物
WO2022228544A1 (zh) 2021-04-29 2022-11-03 苏州盛迪亚生物医药有限公司 异喹啉酮类化合物及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6258833B1 (en) * 1999-12-23 2001-07-10 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
EA200300622A1 (ru) * 2001-01-31 2003-12-25 Пфайзер Продактс Инк. Производные амидов тиазолил-, оксазолил, пирролил- и имидазолилкислот, полезные в качестве ингибиторов изоферментов pde4
BRPI0616633A2 (pt) 2005-09-29 2011-06-28 Bayer Healthcare Ag inibidores de pde e combinações dos mesmos para o tratamento de transtornos urológicos
TW201206440A (en) 2010-04-28 2012-02-16 Astellas Pharma Inc Prophylactic or therapeutic agent for diseases associated with pains in urinary organs
JO3264B1 (ar) * 2013-03-13 2018-09-16 Lilly Co Eli مركبات ازيتيدينيل أوكسي فينيل بيروليدين
WO2016033776A1 (en) * 2014-09-04 2016-03-10 Eli Lilly And Company Crystalline (2s) -3- [ (3s, 4s) -3- [ (1r) -1-hydroxyethyl] -4- (4-methoxy-3- { [1- (5-methylpyridin-2-yl) azetidin-3-yl] oxy} phenyl) -3-methylpyrrolidin-1-yl] -3-oxopropane-1, 2-diol

Also Published As

Publication number Publication date
PL3191466T3 (pl) 2020-05-18
ECSP17014972A (es) 2018-03-31
PE20170328A1 (es) 2017-04-19
EP3191466A1 (en) 2017-07-19
EA201790156A1 (ru) 2017-06-30
PH12017500459A1 (en) 2017-07-31
LT3191466T (lt) 2020-02-25
CO2017001389A2 (es) 2017-05-10
HUE047551T2 (hu) 2020-04-28
KR101857931B1 (ko) 2018-05-14
CN106795137B (zh) 2020-08-25
US20200002318A1 (en) 2020-01-02
AU2015315533B2 (en) 2018-03-15
US20170240532A1 (en) 2017-08-24
DK3191466T3 (da) 2020-01-20
HRP20200119T1 (hr) 2020-04-03
EP3191466B1 (en) 2019-12-04
TN2017000047A1 (en) 2018-07-04
CL2017000484A1 (es) 2017-11-10
SG11201701225YA (en) 2017-03-30
JP2017527587A (ja) 2017-09-21
MX2017003138A (es) 2017-05-23
ZA201700555B (en) 2018-12-19
BR112017002852A2 (pt) 2017-12-26
SI3191466T1 (sl) 2020-02-28
CR20170050A (es) 2017-04-25
CA2955634A1 (en) 2016-03-17
TW201625591A (zh) 2016-07-16
AU2015315533A1 (en) 2017-02-23
EA030034B1 (ru) 2018-06-29
JP6285610B2 (ja) 2018-02-28
RS59845B1 (sr) 2020-02-28
NZ729087A (en) 2018-07-27
US10781202B2 (en) 2020-09-22
ES2770047T3 (es) 2020-06-30
AP2017009778A0 (en) 2017-03-31
PT3191466T (pt) 2020-02-17
KR20170040803A (ko) 2017-04-13
IL250378A0 (en) 2017-03-30
CN106795137A (zh) 2017-05-31
WO2016040083A1 (en) 2016-03-17

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