ECSP21031085A - Nuevas 6,7-dihidro-4h-pirazolo[1,5-a] pirazinindol-2-carboxamidas activas contra el virus de la hepatitis b (vhb) - Google Patents

Nuevas 6,7-dihidro-4h-pirazolo[1,5-a] pirazinindol-2-carboxamidas activas contra el virus de la hepatitis b (vhb)

Info

Publication number
ECSP21031085A
ECSP21031085A ECSENADI202131085A ECDI202131085A ECSP21031085A EC SP21031085 A ECSP21031085 A EC SP21031085A EC SENADI202131085 A ECSENADI202131085 A EC SENADI202131085A EC DI202131085 A ECDI202131085 A EC DI202131085A EC SP21031085 A ECSP21031085 A EC SP21031085A
Authority
EC
Ecuador
Prior art keywords
hbv
virus
hepatitis
new
pirazinindol
Prior art date
Application number
ECSENADI202131085A
Other languages
English (en)
Inventor
Jasper Springer
Susanne Bonsmann
Alastair Donald
Anita Wegert
Andreas Urban
Original Assignee
Aicuris Gmbh Co Kg [De/De]
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh Co Kg [De/De] filed Critical Aicuris Gmbh Co Kg [De/De]
Publication of ECSP21031085A publication Critical patent/ECSP21031085A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere, en general, a nuevos agentes antivíricos. Específicamente, la presente invención se refiere a compuestos que pueden inhibir la proteína o proteínas codificada(s) por el virus de la hepatitis B (VHB) o interferir con la función del ciclo de replicación del VHB, a composiciones que comprenden estos Compuestos, a métodos para inhibir la replicación del virus VHB, a métodos para tratar o prevenir la infección por VHB y a procesos o intermedios para fabricar los compuestos.
ECSENADI202131085A 2018-11-02 2021-04-29 Nuevas 6,7-dihidro-4h-pirazolo[1,5-a] pirazinindol-2-carboxamidas activas contra el virus de la hepatitis b (vhb) ECSP21031085A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18000876 2018-11-02

Publications (1)

Publication Number Publication Date
ECSP21031085A true ECSP21031085A (es) 2021-05-31

Family

ID=64362286

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202131085A ECSP21031085A (es) 2018-11-02 2021-04-29 Nuevas 6,7-dihidro-4h-pirazolo[1,5-a] pirazinindol-2-carboxamidas activas contra el virus de la hepatitis b (vhb)

Country Status (20)

Country Link
US (1) US20220363686A1 (es)
EP (1) EP3873909A1 (es)
JP (1) JP2022512871A (es)
KR (1) KR20210099562A (es)
CN (1) CN113056467A (es)
AR (1) AR116947A1 (es)
AU (1) AU2019370994A1 (es)
BR (1) BR112021008361A2 (es)
CA (1) CA3118380A1 (es)
CL (1) CL2021001117A1 (es)
CU (1) CU20210038A7 (es)
EA (1) EA202191216A1 (es)
EC (1) ECSP21031085A (es)
IL (1) IL282480A (es)
MX (1) MX2021004986A (es)
PH (1) PH12021550979A1 (es)
SG (1) SG11202104130SA (es)
TW (1) TW202031661A (es)
UY (1) UY38436A (es)
WO (1) WO2020089453A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR117189A1 (es) * 2018-11-02 2021-07-21 Aicuris Gmbh & Co Kg Derivados de 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activos contra el virus de la hepatitis b (vhb)
UY38437A (es) * 2018-11-02 2020-05-29 Aicuris Gmbh & Co Kg Nuevas urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (hbv)
JP2023513272A (ja) 2020-02-07 2023-03-30 ガシャーブラム・バイオ・インコーポレイテッド ヘテロ環ｇｌｐ－１アゴニスト
CN116368140A (zh) * 2020-09-10 2023-06-30 加舒布鲁姆生物公司 杂环glp-1激动剂

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Also Published As

Publication number Publication date
PH12021550979A1 (en) 2021-11-22
KR20210099562A (ko) 2021-08-12
CL2021001117A1 (es) 2021-11-05
TW202031661A (zh) 2020-09-01
US20220363686A1 (en) 2022-11-17
EP3873909A1 (en) 2021-09-08
AR116947A1 (es) 2021-06-30
JP2022512871A (ja) 2022-02-07
CU20210038A7 (es) 2021-12-08
UY38436A (es) 2020-05-29
IL282480A (en) 2021-06-30
MX2021004986A (es) 2021-06-15
CA3118380A1 (en) 2020-05-07
CN113056467A (zh) 2021-06-29
WO2020089453A1 (en) 2020-05-07
EA202191216A1 (ru) 2021-08-03
BR112021008361A2 (pt) 2021-08-03
AU2019370994A1 (en) 2021-05-27
SG11202104130SA (en) 2021-05-28

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