UY38437A - Nuevas urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (hbv) - Google Patents
Nuevas urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (hbv)Info
- Publication number
- UY38437A UY38437A UY0001038437A UY38437A UY38437A UY 38437 A UY38437 A UY 38437A UY 0001038437 A UY0001038437 A UY 0001038437A UY 38437 A UY38437 A UY 38437A UY 38437 A UY38437 A UY 38437A
- Authority
- UY
- Uruguay
- Prior art keywords
- hbv
- virus
- hepatitis
- pirazolo
- dihidro
- Prior art date
Links
- 241000700721 Hepatitis B virus Species 0.000 title abstract 5
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 title 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title 1
- 239000004202 carbamide Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000010076 replication Effects 0.000 abstract 2
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención se refiere, en general, a nuevos agentes antivíricos. Específicamente, la presente invención se refiere a compuestos que pueden inhibir la proteína o proteínas codificada(s) por el virus de la hepatitis B (VHB) o interferir con la función del ciclo de replicación del VHB, a composiciones que comprenden dichos compuestos, a métodos para inhibir la replicación del virus VHB, a métodos para tratar o prevenir la infección por VHB y a procesos o intermedios para fabricar los compuestos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18000877 | 2018-11-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY38437A true UY38437A (es) | 2020-05-29 |
Family
ID=64362287
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001038437A UY38437A (es) | 2018-11-02 | 2019-10-31 | Nuevas urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (hbv) |
Country Status (19)
Country | Link |
---|---|
US (1) | US20210355129A1 (es) |
EP (1) | EP3873908A1 (es) |
JP (1) | JP2022512870A (es) |
KR (1) | KR20210098986A (es) |
CN (1) | CN113039186A (es) |
AR (1) | AR117188A1 (es) |
AU (1) | AU2019370735A1 (es) |
BR (1) | BR112021008360A2 (es) |
CA (1) | CA3118387A1 (es) |
CL (1) | CL2021001116A1 (es) |
CU (1) | CU20210037A7 (es) |
EA (1) | EA202191219A1 (es) |
EC (1) | ECSP21031082A (es) |
IL (1) | IL282587A (es) |
MX (1) | MX2021004987A (es) |
SG (1) | SG11202104126UA (es) |
TW (1) | TW202031662A (es) |
UY (1) | UY38437A (es) |
WO (1) | WO2020089459A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2019168847A1 (en) | 2018-02-27 | 2019-09-06 | Incyte Corporation | Imidazopyrimidines and triazolopyrimidines as a2a / a2b inhibitors |
EP3810610A1 (en) | 2018-05-18 | 2021-04-28 | Incyte Corporation | Fused pyrimidine derivatives as a2a / a2b inhibitors |
KR20210049090A (ko) | 2018-07-05 | 2021-05-04 | 인사이트 코포레이션 | A2a/a2b 억제제로서 융합된 피라진 유도체 |
AR117189A1 (es) * | 2018-11-02 | 2021-07-21 | Aicuris Gmbh & Co Kg | Derivados de 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activos contra el virus de la hepatitis b (vhb) |
UY38436A (es) * | 2018-11-02 | 2020-05-29 | Aicuris Gmbh & Co Kg | Nuevas 6,7-dihidro-4h-pirazolo[1,5-a] pirazinindol-2-carboxamidas activas contra el virus de la hepatitis b (vhb) |
TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
SG11202111333UA (en) * | 2019-04-30 | 2021-11-29 | Aicuris Gmbh & Co Kg | Novel phenyl and pyridyl ureas active against the hepatitis b virus (hbv) |
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DE19817264A1 (de) | 1998-04-18 | 1999-10-21 | Bayer Ag | Neue Dihydropyrimidine |
AU4289100A (en) | 1999-03-25 | 2000-10-16 | Bayer Aktiengesellschaft | Dihydropyrimidines and their use in the treatment of hepatitis |
WO2001006840A1 (en) | 1999-04-23 | 2001-02-01 | Jonathan Dallas Toye | Sheet fastening and anchoring component |
AU3009801A (en) | 1999-12-22 | 2001-07-03 | Bayer Aktiengesellschaft | Combinations of medicaments for treating viral diseases |
WO2006033995A2 (en) | 2004-09-16 | 2006-03-30 | Valeant Research And Development | Thiazolidin-4-ones having anti-hepatitis b activity |
JP5977347B2 (ja) | 2011-07-01 | 2016-08-24 | バルーク エス.ブルームバーグ インスティテュート | Hbv感染に対する抗ウイルス剤としてのスルファモイルベンズアミド誘導体 |
WO2013036994A1 (en) * | 2011-09-16 | 2013-03-21 | Biota Scientific Management Pty Ltd | Compounds for the treatment of hcv |
SG11201402660YA (en) | 2011-12-21 | 2014-10-30 | Novira Therapeutics Inc | Hepatitis b antiviral agents |
CN104302626B (zh) | 2012-01-06 | 2016-09-07 | 爱尔兰詹森科学公司 | 4,4-二取代的-1,4-二氢嘧啶及其作为治疗乙型肝炎的药物的用途 |
KR102122244B1 (ko) | 2012-08-28 | 2020-06-15 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 설파모일-아릴아미드 및 b형 간염 치료제로서의 그 용도 |
JP6285440B2 (ja) | 2012-08-28 | 2018-02-28 | ヤンセン・サイエンシズ・アイルランド・ユーシー | 融合二環式スルファモイル誘導体並びにb型肝炎の治療のための薬剤としてのその使用 |
WO2014165128A2 (en) | 2013-03-12 | 2014-10-09 | Novira Therapeutics, Inc. | Hepatitis b antiviral agents |
PE20151951A1 (es) | 2013-05-17 | 2015-12-26 | Hoffmann La Roche | Heteroarildihidropirimidinas unidas por puentes en 6 para el tratamiento y la profilaxis de infeccion por el virus de la hepatitis b |
AU2014267235B2 (en) | 2013-05-17 | 2017-10-05 | Janssen Sciences Ireland Uc | Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
CN108047115B (zh) | 2013-07-25 | 2021-06-29 | 爱尔兰詹森科学公司 | 经乙醛酰胺取代的吡咯酰胺衍生物及其作为药物用于治疗乙型肝炎的用途 |
WO2015057945A1 (en) | 2013-10-18 | 2015-04-23 | Indiana University Research And Technology Corporation | Hepatitis b viral assembly effectors |
WO2015073774A1 (en) | 2013-11-14 | 2015-05-21 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis b infections |
US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
WO2015133428A1 (ja) | 2014-03-06 | 2015-09-11 | 株式会社テイエルブイ | 蒸気システム |
EP3114128B1 (en) | 2014-03-07 | 2019-01-02 | F. Hoffmann-La Roche AG | Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection |
PT3116316T (pt) | 2014-03-13 | 2019-09-30 | Assembly Biosciences Inc | Moduladores alostéricos da proteína do núcleo da hepatite b |
MY196243A (en) | 2014-03-28 | 2023-03-24 | Sunshine Lake Pharma Co Ltd | Dihydropyrimidine Compounds and Their Application In Pharmaceuticals |
CA2948580A1 (en) | 2014-05-09 | 2015-11-12 | Adam Zlotnick | Methods and compositions for treating hepatitis b virus infections |
WO2016023877A1 (en) | 2014-08-14 | 2016-02-18 | F. Hoffmann-La Roche Ag | Novel pyridazones and triazinones for the treatment and prophylaxis of hepatitis b virus infection |
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CN107531691A (zh) | 2014-12-30 | 2018-01-02 | 诺维拉治疗公司 | 治疗乙型肝炎感染的衍生物和方法 |
MA41338B1 (fr) | 2015-01-16 | 2019-07-31 | Hoffmann La Roche | Composés de pyrazine pour le traitement de maladies infectieuses |
KR102359212B1 (ko) | 2015-03-16 | 2022-02-08 | 에프. 호프만-라 로슈 아게 | Tlr7 작용제 및 hbv 캡시드 조립 억제제를 사용하는 병용 치료 |
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WO2017013046A1 (en) | 2015-07-21 | 2017-01-26 | F. Hoffmann-La Roche Ag | Novel tricyclic 4-pyridone-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection |
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TW201720802A (zh) | 2015-09-15 | 2017-06-16 | 艾森伯利生物科學公司 | B型肝炎核心蛋白質調節劑 |
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CN109153682B (zh) * | 2016-05-20 | 2021-05-25 | 豪夫迈·罗氏有限公司 | 用于治疗感染性疾病的具有氧、硫和氮连接基的新的吡嗪化合物 |
WO2018011160A1 (en) | 2016-07-14 | 2018-01-18 | F. Hoffmann-La Roche Ag | 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazine compounds for the treatment of infectious diseases |
EP3484886B1 (en) | 2016-07-14 | 2020-03-04 | Hoffmann-La Roche AG | 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazine and 6,7-dihydro-4h-triazolo[1,5-a]pyrazine compounds for the treatment of infectious diseases |
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JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
CA3036245C (en) | 2016-09-13 | 2021-07-20 | Arbutus Biopharma Corporation | Substituted chromane-8-carboxamide compounds and analogues thereof, and methods using same |
EP3589630B1 (en) | 2017-03-02 | 2021-07-07 | Assembly Biosciences, Inc. | Cyclic sulfamide compounds and methods of using same |
SG11201908569QA (en) | 2017-03-21 | 2019-10-30 | Arbutus Biopharma Corp | Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same |
CN109952305B (zh) * | 2017-07-27 | 2022-06-21 | 江苏恒瑞医药股份有限公司 | 哌嗪并杂芳基类衍生物、其制备方法及其在医药上的应用 |
KR20200083552A (ko) * | 2017-11-02 | 2020-07-08 | 아이쿠리스 게엠베하 운트 코. 카게 | B형 간염 바이러스 (hbv)에 활성인 신규 고활성 피라졸로-피페리딘 치환된 인돌-2-카르복스아미드 |
UY38435A (es) * | 2018-11-02 | 2020-05-29 | Aicuris Gmbh & Co Kg | Nuevas urea 6,7-dihidro-4h-pirazol[1,5-a] pirazinas activas contra el virus de la hepatitis b (vhb) |
UY38436A (es) * | 2018-11-02 | 2020-05-29 | Aicuris Gmbh & Co Kg | Nuevas 6,7-dihidro-4h-pirazolo[1,5-a] pirazinindol-2-carboxamidas activas contra el virus de la hepatitis b (vhb) |
AR116946A1 (es) * | 2018-11-02 | 2021-06-30 | Aicuris Gmbh & Co Kg | Derivados de urea 6,7-dihidro-4h-pirazolo[4,3-c]piridinas activas contra el virus de la hepatitis b (vhb) |
-
2019
- 2019-10-31 AR ARP190103179A patent/AR117188A1/es unknown
- 2019-10-31 UY UY0001038437A patent/UY38437A/es not_active Application Discontinuation
- 2019-11-01 US US17/290,417 patent/US20210355129A1/en not_active Abandoned
- 2019-11-01 SG SG11202104126UA patent/SG11202104126UA/en unknown
- 2019-11-01 EA EA202191219A patent/EA202191219A1/ru unknown
- 2019-11-01 AU AU2019370735A patent/AU2019370735A1/en not_active Abandoned
- 2019-11-01 CU CU2021000037A patent/CU20210037A7/es unknown
- 2019-11-01 KR KR1020217016303A patent/KR20210098986A/ko not_active Application Discontinuation
- 2019-11-01 EP EP19795567.7A patent/EP3873908A1/en not_active Withdrawn
- 2019-11-01 MX MX2021004987A patent/MX2021004987A/es unknown
- 2019-11-01 CN CN201980072953.XA patent/CN113039186A/zh active Pending
- 2019-11-01 WO PCT/EP2019/079977 patent/WO2020089459A1/en active Application Filing
- 2019-11-01 JP JP2021523652A patent/JP2022512870A/ja active Pending
- 2019-11-01 TW TW108139834A patent/TW202031662A/zh unknown
- 2019-11-01 BR BR112021008360-0A patent/BR112021008360A2/pt not_active Application Discontinuation
- 2019-11-01 CA CA3118387A patent/CA3118387A1/en not_active Abandoned
-
2021
- 2021-04-22 IL IL282587A patent/IL282587A/en unknown
- 2021-04-29 CL CL2021001116A patent/CL2021001116A1/es unknown
- 2021-04-29 EC ECSENADI202131082A patent/ECSP21031082A/es unknown
Also Published As
Publication number | Publication date |
---|---|
KR20210098986A (ko) | 2021-08-11 |
AU2019370735A1 (en) | 2021-05-27 |
WO2020089459A1 (en) | 2020-05-07 |
AR117188A1 (es) | 2021-07-21 |
TW202031662A (zh) | 2020-09-01 |
IL282587A (en) | 2021-06-30 |
CL2021001116A1 (es) | 2021-11-05 |
SG11202104126UA (en) | 2021-05-28 |
CU20210037A7 (es) | 2021-12-08 |
ECSP21031082A (es) | 2021-05-31 |
MX2021004987A (es) | 2021-06-15 |
EA202191219A1 (ru) | 2021-07-28 |
CA3118387A1 (en) | 2020-05-07 |
US20210355129A1 (en) | 2021-11-18 |
BR112021008360A2 (pt) | 2021-08-03 |
EP3873908A1 (en) | 2021-09-08 |
CN113039186A (zh) | 2021-06-25 |
JP2022512870A (ja) | 2022-02-07 |
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Legal Events
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109 | Application deemed to be withdrawn |
Effective date: 20240610 |