SG11202104126UA - Novel urea 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazines active against the hepatitis b virus (hbv) - Google Patents
Novel urea 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazines active against the hepatitis b virus (hbv)Info
- Publication number
- SG11202104126UA SG11202104126UA SG11202104126UA SG11202104126UA SG11202104126UA SG 11202104126U A SG11202104126U A SG 11202104126UA SG 11202104126U A SG11202104126U A SG 11202104126UA SG 11202104126U A SG11202104126U A SG 11202104126UA SG 11202104126U A SG11202104126U A SG 11202104126UA
- Authority
- SG
- Singapore
- Prior art keywords
- pyrazines
- hbv
- pyrazolo
- hepatitis
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18000877 | 2018-11-02 | ||
PCT/EP2019/079977 WO2020089459A1 (en) | 2018-11-02 | 2019-11-01 | Novel urea 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazines active against the hepatitis b virus (hbv) |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202104126UA true SG11202104126UA (en) | 2021-05-28 |
Family
ID=64362287
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202104126UA SG11202104126UA (en) | 2018-11-02 | 2019-11-01 | Novel urea 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazines active against the hepatitis b virus (hbv) |
Country Status (19)
Country | Link |
---|---|
US (1) | US20210355129A1 (en) |
EP (1) | EP3873908A1 (en) |
JP (1) | JP2022512870A (en) |
KR (1) | KR20210098986A (en) |
CN (1) | CN113039186A (en) |
AR (1) | AR117188A1 (en) |
AU (1) | AU2019370735A1 (en) |
BR (1) | BR112021008360A2 (en) |
CA (1) | CA3118387A1 (en) |
CL (1) | CL2021001116A1 (en) |
CU (1) | CU20210037A7 (en) |
EA (1) | EA202191219A1 (en) |
EC (1) | ECSP21031082A (en) |
IL (1) | IL282587A (en) |
MX (1) | MX2021004987A (en) |
SG (1) | SG11202104126UA (en) |
TW (1) | TW202031662A (en) |
UY (1) | UY38437A (en) |
WO (1) | WO2020089459A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN117903140A (en) | 2018-02-27 | 2024-04-19 | 因赛特公司 | Imidazopyrimidines and triazolopyrimidines as A2A/A2B inhibitors |
CA3100731A1 (en) | 2018-05-18 | 2019-11-21 | Incyte Corporation | Fused pyrimidine derivatives as a2a / a2b inhibitors |
TWI829716B (en) | 2018-07-05 | 2024-01-21 | 美商英塞特公司 | Fused pyrazine derivatives as a2a / a2b inhibitors |
UY38436A (en) * | 2018-11-02 | 2020-05-29 | Aicuris Gmbh & Co Kg | NEW 6,7-DIHYDRO-4H-PYRAZOLE [1,5-A] PYRAZININDOL-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) |
AR117189A1 (en) * | 2018-11-02 | 2021-07-21 | Aicuris Gmbh & Co Kg | DERIVATIVES OF 6,7-DIHIDRO-4H-PIRAZOLO [1,5-A] PIRAZIN INDOL-2-CARBOXAMIDAS ACTIVE AGAINST THE VIRUS OF HEPATITIS B (HBV) |
TWI829857B (en) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | Pyrazolopyridines and triazolopyridines as a2a / a2b inhibitors |
CA3138384A1 (en) * | 2019-04-30 | 2020-11-05 | Aicuris Gmbh & Co. Kg | Novel phenyl and pyridyl ureas active against the hepatitis b virus (hbv) |
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AU4289100A (en) | 1999-03-25 | 2000-10-16 | Bayer Aktiengesellschaft | Dihydropyrimidines and their use in the treatment of hepatitis |
AU768560B2 (en) | 1999-04-23 | 2003-12-18 | Extenday Ip Limited | Sheet fastening and anchoring component |
AU3009801A (en) | 1999-12-22 | 2001-07-03 | Bayer Aktiengesellschaft | Combinations of medicaments for treating viral diseases |
WO2006033995A2 (en) | 2004-09-16 | 2006-03-30 | Valeant Research And Development | Thiazolidin-4-ones having anti-hepatitis b activity |
EP3085368A1 (en) | 2011-07-01 | 2016-10-26 | Baruch S. Blumberg Institute | Sulfamoylbenzamide derivatives as antiviral agents against hbv infection |
WO2013036994A1 (en) * | 2011-09-16 | 2013-03-21 | Biota Scientific Management Pty Ltd | Compounds for the treatment of hcv |
US8629274B2 (en) | 2011-12-21 | 2014-01-14 | Novira Therapeutics, Inc. | Hepatitis B antiviral agents |
EP2800742B1 (en) | 2012-01-06 | 2016-04-06 | Janssen Sciences Ireland UC | 4,4-disubstituted-1,4-dihydropyrimidines and the use thereof as medicaments for the treatment of hepatitis b |
UY34993A (en) | 2012-08-28 | 2014-02-28 | Janssen R & D Ireland | SULFAMOILARILAMIDAS AND ITS USE AS MEDICINES FOR THE TREATMENT OF HEPATITIS B |
BR112015004161B8 (en) | 2012-08-28 | 2022-11-08 | Janssen Sciences Ireland Uc | FUSIONED BICYCLIC SULFAMOYL DERIVATIVE AND ITS USE IN THE TREATMENT AND PREVENTION OF INFECTION BY HEPATITIS B VIRUS, AS WELL AS PHARMACEUTICAL COMPOSITION AND PRODUCT THAT COMPRISES IT |
US8993771B2 (en) | 2013-03-12 | 2015-03-31 | Novira Therapeutics, Inc. | Hepatitis B antiviral agents |
LT2997019T (en) | 2013-05-17 | 2018-11-26 | Janssen Sciences Ireland Uc | Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
JP6533217B2 (en) | 2013-05-17 | 2019-06-19 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 6-Bridged Heteroaryldihydropyrimidines for the Treatment and Prevention of Hepatitis B Virus Infection |
SG11201600522UA (en) | 2013-07-25 | 2016-02-26 | Janssen Sciences Ireland Uc | Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
CA2927560A1 (en) | 2013-10-18 | 2015-04-23 | Indiana University Research And Technology Corporation | Hepatitis b viral assembly effectors |
KR20160127714A (en) | 2013-11-14 | 2016-11-04 | 노비라 테라퓨틱스, 인코포레이티드 | Azepane derivatives and methods of treating hepatitis b infections |
US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
WO2015133428A1 (en) | 2014-03-06 | 2015-09-11 | 株式会社テイエルブイ | Steam system |
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US10183936B2 (en) | 2014-03-13 | 2019-01-22 | Indiana University Research And Technology Corporation | Hepatitis B core protein allosteric modulators |
KR20160133563A (en) | 2014-03-28 | 2016-11-22 | 선샤인 레이크 파르마 컴퍼니 리미티드 | Dihydropyrimidine compounds and their application in pharmaceuticals |
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KR20170118706A (en) | 2014-12-30 | 2017-10-25 | 노비라 테라퓨틱스, 인코포레이티드 | Derivatives and methods for treating hepatitis B infection |
MA41338B1 (en) | 2015-01-16 | 2019-07-31 | Hoffmann La Roche | Pyrazine compounds for the treatment of infectious diseases |
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WO2017198744A1 (en) * | 2016-05-20 | 2017-11-23 | F. Hoffmann-La Roche Ag | Novel pyrazine compounds with oxygen, sulfur and nitrogen linker for the treatment of infectious diseases |
WO2018011160A1 (en) | 2016-07-14 | 2018-01-18 | F. Hoffmann-La Roche Ag | 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazine compounds for the treatment of infectious diseases |
JP7034133B2 (en) | 2016-07-14 | 2022-03-11 | エフ.ホフマン-ラ ロシュ アーゲー | Carboxyl 6,7-dihydro-4H-pyrazolo [1,5-a] pyrazine compounds for the treatment of infectious diseases |
JP7051804B2 (en) | 2016-07-14 | 2022-04-11 | エフ.ホフマン-ラ ロシュ アーゲー | 6,7-dihydro-4H-pyrazolo [1,5-a] pyrazine compound and 6,7-dihydro-4H-triazolo [1,5-a] pyrazine compound for the treatment of infectious diseases |
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TW201925199A (en) * | 2017-11-02 | 2019-07-01 | 德商艾庫瑞斯公司 | Novel, highly active pyrazolo-piperidine substituted indole-2-carboxamides active against the hepatitis B virus (HBV) |
AR116948A1 (en) * | 2018-11-02 | 2021-06-30 | Aicuris Gmbh & Co Kg | DERIVATIVES OF UREA 6,7-DIHIDRO-4H-PIRAZOLO [1,5-A] PYRAZINES ACTIVE AGAINST THE VIRUS OF HEPATITIS B (HBV) |
AR116946A1 (en) * | 2018-11-02 | 2021-06-30 | Aicuris Gmbh & Co Kg | DERIVATIVES OF UREA 6,7-DIHIDRO-4H-PIRAZOLO [4,3-C] PYRIDINES ACTIVE AGAINST THE VIRUS OF HEPATITIS B (HBV) |
UY38436A (en) * | 2018-11-02 | 2020-05-29 | Aicuris Gmbh & Co Kg | NEW 6,7-DIHYDRO-4H-PYRAZOLE [1,5-A] PYRAZININDOL-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) |
-
2019
- 2019-10-31 UY UY0001038437A patent/UY38437A/en unknown
- 2019-10-31 AR ARP190103179A patent/AR117188A1/en unknown
- 2019-11-01 MX MX2021004987A patent/MX2021004987A/en unknown
- 2019-11-01 SG SG11202104126UA patent/SG11202104126UA/en unknown
- 2019-11-01 WO PCT/EP2019/079977 patent/WO2020089459A1/en unknown
- 2019-11-01 KR KR1020217016303A patent/KR20210098986A/en not_active Application Discontinuation
- 2019-11-01 TW TW108139834A patent/TW202031662A/en unknown
- 2019-11-01 US US17/290,417 patent/US20210355129A1/en active Pending
- 2019-11-01 JP JP2021523652A patent/JP2022512870A/en active Pending
- 2019-11-01 CA CA3118387A patent/CA3118387A1/en not_active Abandoned
- 2019-11-01 EA EA202191219A patent/EA202191219A1/en unknown
- 2019-11-01 CU CU2021000037A patent/CU20210037A7/en unknown
- 2019-11-01 BR BR112021008360-0A patent/BR112021008360A2/en not_active Application Discontinuation
- 2019-11-01 CN CN201980072953.XA patent/CN113039186A/en active Pending
- 2019-11-01 AU AU2019370735A patent/AU2019370735A1/en not_active Abandoned
- 2019-11-01 EP EP19795567.7A patent/EP3873908A1/en not_active Withdrawn
-
2021
- 2021-04-22 IL IL282587A patent/IL282587A/en unknown
- 2021-04-29 EC ECSENADI202131082A patent/ECSP21031082A/en unknown
- 2021-04-29 CL CL2021001116A patent/CL2021001116A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
UY38437A (en) | 2020-05-29 |
EP3873908A1 (en) | 2021-09-08 |
BR112021008360A2 (en) | 2021-08-03 |
CN113039186A (en) | 2021-06-25 |
JP2022512870A (en) | 2022-02-07 |
CU20210037A7 (en) | 2021-12-08 |
TW202031662A (en) | 2020-09-01 |
KR20210098986A (en) | 2021-08-11 |
EA202191219A1 (en) | 2021-07-28 |
US20210355129A1 (en) | 2021-11-18 |
AR117188A1 (en) | 2021-07-21 |
CA3118387A1 (en) | 2020-05-07 |
CL2021001116A1 (en) | 2021-11-05 |
IL282587A (en) | 2021-06-30 |
MX2021004987A (en) | 2021-06-15 |
WO2020089459A1 (en) | 2020-05-07 |
AU2019370735A1 (en) | 2021-05-27 |
ECSP21031082A (en) | 2021-05-31 |
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