CU20210037A7 - Compuestos derivados sustituidos de urea 6,7-dihidro-4h-pirazolo [1,5-a] pirazinas activas contra el virus de la hepatitis b (vhb) - Google Patents
Compuestos derivados sustituidos de urea 6,7-dihidro-4h-pirazolo [1,5-a] pirazinas activas contra el virus de la hepatitis b (vhb)Info
- Publication number
- CU20210037A7 CU20210037A7 CU2021000037A CU20210037A CU20210037A7 CU 20210037 A7 CU20210037 A7 CU 20210037A7 CU 2021000037 A CU2021000037 A CU 2021000037A CU 20210037 A CU20210037 A CU 20210037A CU 20210037 A7 CU20210037 A7 CU 20210037A7
- Authority
- CU
- Cuba
- Prior art keywords
- virus
- pyrazines
- hbv
- dihydro
- urea
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
<p>La presente invención se refiere a compuestos derivados sustituidos de urea 6,7-dihidro-4h-pirazolo [1,5-a] pirazinas activas de fórmula II;</p> <p>ESPACIO PARA LA FÓRMULA</p> <p>útiles para inhibir la proteína o proteínas codificadas por el virus de la hepatitis B (VHB) o interferir con la función del ciclo de replicación de dicho virus. La invención se refiere además a composiciones que comprenden dichos compuestos y a procesos o intermedios para fabricarlos. </p>
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18000877 | 2018-11-02 | ||
PCT/EP2019/079977 WO2020089459A1 (en) | 2018-11-02 | 2019-11-01 | Novel urea 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazines active against the hepatitis b virus (hbv) |
Publications (1)
Publication Number | Publication Date |
---|---|
CU20210037A7 true CU20210037A7 (es) | 2021-12-08 |
Family
ID=64362287
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU2021000037A CU20210037A7 (es) | 2018-11-02 | 2019-11-01 | Compuestos derivados sustituidos de urea 6,7-dihidro-4h-pirazolo [1,5-a] pirazinas activas contra el virus de la hepatitis b (vhb) |
Country Status (19)
Country | Link |
---|---|
US (1) | US20210355129A1 (es) |
EP (1) | EP3873908A1 (es) |
JP (1) | JP2022512870A (es) |
KR (1) | KR20210098986A (es) |
CN (1) | CN113039186A (es) |
AR (1) | AR117188A1 (es) |
AU (1) | AU2019370735A1 (es) |
BR (1) | BR112021008360A2 (es) |
CA (1) | CA3118387A1 (es) |
CL (1) | CL2021001116A1 (es) |
CU (1) | CU20210037A7 (es) |
EA (1) | EA202191219A1 (es) |
EC (1) | ECSP21031082A (es) |
IL (1) | IL282587A (es) |
MX (1) | MX2021004987A (es) |
SG (1) | SG11202104126UA (es) |
TW (1) | TW202031662A (es) |
UY (1) | UY38437A (es) |
WO (1) | WO2020089459A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN117903140A (zh) | 2018-02-27 | 2024-04-19 | 因赛特公司 | 作为a2a/a2b抑制剂的咪唑并嘧啶和三唑并嘧啶 |
CA3100731A1 (en) | 2018-05-18 | 2019-11-21 | Incyte Corporation | Fused pyrimidine derivatives as a2a / a2b inhibitors |
TWI829716B (zh) | 2018-07-05 | 2024-01-21 | 美商英塞特公司 | 作為a2a/a2b 抑制劑之稠合吡嗪衍生物 |
UY38436A (es) * | 2018-11-02 | 2020-05-29 | Aicuris Gmbh & Co Kg | Nuevas 6,7-dihidro-4h-pirazolo[1,5-a] pirazinindol-2-carboxamidas activas contra el virus de la hepatitis b (vhb) |
AR117189A1 (es) * | 2018-11-02 | 2021-07-21 | Aicuris Gmbh & Co Kg | Derivados de 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activos contra el virus de la hepatitis b (vhb) |
TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
CA3138384A1 (en) * | 2019-04-30 | 2020-11-05 | Aicuris Gmbh & Co. Kg | Novel phenyl and pyridyl ureas active against the hepatitis b virus (hbv) |
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DE19817264A1 (de) | 1998-04-18 | 1999-10-21 | Bayer Ag | Neue Dihydropyrimidine |
AU4289100A (en) | 1999-03-25 | 2000-10-16 | Bayer Aktiengesellschaft | Dihydropyrimidines and their use in the treatment of hepatitis |
AU768560B2 (en) | 1999-04-23 | 2003-12-18 | Extenday Ip Limited | Sheet fastening and anchoring component |
AU3009801A (en) | 1999-12-22 | 2001-07-03 | Bayer Aktiengesellschaft | Combinations of medicaments for treating viral diseases |
WO2006033995A2 (en) | 2004-09-16 | 2006-03-30 | Valeant Research And Development | Thiazolidin-4-ones having anti-hepatitis b activity |
EP3085368A1 (en) | 2011-07-01 | 2016-10-26 | Baruch S. Blumberg Institute | Sulfamoylbenzamide derivatives as antiviral agents against hbv infection |
WO2013036994A1 (en) * | 2011-09-16 | 2013-03-21 | Biota Scientific Management Pty Ltd | Compounds for the treatment of hcv |
US8629274B2 (en) | 2011-12-21 | 2014-01-14 | Novira Therapeutics, Inc. | Hepatitis B antiviral agents |
EP2800742B1 (en) | 2012-01-06 | 2016-04-06 | Janssen Sciences Ireland UC | 4,4-disubstituted-1,4-dihydropyrimidines and the use thereof as medicaments for the treatment of hepatitis b |
UY34993A (es) | 2012-08-28 | 2014-02-28 | Janssen R & D Ireland | Sulfamoilarilamidas y su uso como medicamentos para el tratamiento de la hepatitis b |
BR112015004161B8 (pt) | 2012-08-28 | 2022-11-08 | Janssen Sciences Ireland Uc | Derivado bicíclico fusionado de sulfamoíla e seu uso no tratamento e prevenção de infecção por vírus da hepatite b, bem como composição farmacêutica e produto que o compreende |
US8993771B2 (en) | 2013-03-12 | 2015-03-31 | Novira Therapeutics, Inc. | Hepatitis B antiviral agents |
LT2997019T (lt) | 2013-05-17 | 2018-11-26 | Janssen Sciences Ireland Uc | Sulfamoiltiofenamido dariniai ir jų panaudojimas kaip vaistų hepatito b gydymui |
JP6533217B2 (ja) | 2013-05-17 | 2019-06-19 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | B型肝炎ウイルス感染症の治療および予防のための6−架橋ヘテロアリールジヒドロピリミジン類 |
SG11201600522UA (en) | 2013-07-25 | 2016-02-26 | Janssen Sciences Ireland Uc | Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
CA2927560A1 (en) | 2013-10-18 | 2015-04-23 | Indiana University Research And Technology Corporation | Hepatitis b viral assembly effectors |
KR20160127714A (ko) | 2013-11-14 | 2016-11-04 | 노비라 테라퓨틱스, 인코포레이티드 | 아제판 유도체 및 b형 간염 감염의 치료 방법 |
US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
WO2015133428A1 (ja) | 2014-03-06 | 2015-09-11 | 株式会社テイエルブイ | 蒸気システム |
HUE041734T2 (hu) | 2014-03-07 | 2019-05-28 | Hoffmann La Roche | Új, 6-tagú gyûrûvel kondenzált heteroarildihidropirimidinek hepatitisz B vírusfertõzés kezelésére és megelõzésére |
US10183936B2 (en) | 2014-03-13 | 2019-01-22 | Indiana University Research And Technology Corporation | Hepatitis B core protein allosteric modulators |
KR20160133563A (ko) | 2014-03-28 | 2016-11-22 | 선샤인 레이크 파르마 컴퍼니 리미티드 | 다이하이드로피리미딘 화합물 및 이의 약제학적 용도 |
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JP7034133B2 (ja) | 2016-07-14 | 2022-03-11 | エフ.ホフマン-ラ ロシュ アーゲー | 感染性疾患の処置のためのカルボキシ 6,7-ジヒドロ-4H-ピラゾロ[1,5-a]ピラジン化合物 |
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SG11201908012SA (en) | 2017-03-02 | 2019-09-27 | Assembly Biosciences Inc | Cyclic sulfamide compounds and methods of using same |
AU2018238138A1 (en) | 2017-03-21 | 2019-10-17 | Arbutus Biopharma Corporation | Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same |
CA3070004A1 (en) * | 2017-07-27 | 2019-01-31 | Jiangsu Hengrui Medicine Co., Ltd. | Piperazine heteroaryl derivative, preparation method therefor and use of same in medicine |
TW201925199A (zh) * | 2017-11-02 | 2019-07-01 | 德商艾庫瑞斯公司 | 對b型肝炎病毒(hbv)具有活性的新穎高活性吡唑并哌啶取代的吲哚-2-甲醯胺 |
AR116948A1 (es) * | 2018-11-02 | 2021-06-30 | Aicuris Gmbh & Co Kg | Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (vhb) |
AR116946A1 (es) * | 2018-11-02 | 2021-06-30 | Aicuris Gmbh & Co Kg | Derivados de urea 6,7-dihidro-4h-pirazolo[4,3-c]piridinas activas contra el virus de la hepatitis b (vhb) |
UY38436A (es) * | 2018-11-02 | 2020-05-29 | Aicuris Gmbh & Co Kg | Nuevas 6,7-dihidro-4h-pirazolo[1,5-a] pirazinindol-2-carboxamidas activas contra el virus de la hepatitis b (vhb) |
-
2019
- 2019-10-31 UY UY0001038437A patent/UY38437A/es unknown
- 2019-10-31 AR ARP190103179A patent/AR117188A1/es unknown
- 2019-11-01 MX MX2021004987A patent/MX2021004987A/es unknown
- 2019-11-01 SG SG11202104126UA patent/SG11202104126UA/en unknown
- 2019-11-01 WO PCT/EP2019/079977 patent/WO2020089459A1/en unknown
- 2019-11-01 KR KR1020217016303A patent/KR20210098986A/ko not_active Application Discontinuation
- 2019-11-01 TW TW108139834A patent/TW202031662A/zh unknown
- 2019-11-01 US US17/290,417 patent/US20210355129A1/en active Pending
- 2019-11-01 JP JP2021523652A patent/JP2022512870A/ja active Pending
- 2019-11-01 CA CA3118387A patent/CA3118387A1/en not_active Abandoned
- 2019-11-01 EA EA202191219A patent/EA202191219A1/ru unknown
- 2019-11-01 CU CU2021000037A patent/CU20210037A7/es unknown
- 2019-11-01 BR BR112021008360-0A patent/BR112021008360A2/pt not_active Application Discontinuation
- 2019-11-01 CN CN201980072953.XA patent/CN113039186A/zh active Pending
- 2019-11-01 AU AU2019370735A patent/AU2019370735A1/en not_active Abandoned
- 2019-11-01 EP EP19795567.7A patent/EP3873908A1/en not_active Withdrawn
-
2021
- 2021-04-22 IL IL282587A patent/IL282587A/en unknown
- 2021-04-29 EC ECSENADI202131082A patent/ECSP21031082A/es unknown
- 2021-04-29 CL CL2021001116A patent/CL2021001116A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
UY38437A (es) | 2020-05-29 |
EP3873908A1 (en) | 2021-09-08 |
BR112021008360A2 (pt) | 2021-08-03 |
CN113039186A (zh) | 2021-06-25 |
JP2022512870A (ja) | 2022-02-07 |
TW202031662A (zh) | 2020-09-01 |
KR20210098986A (ko) | 2021-08-11 |
EA202191219A1 (ru) | 2021-07-28 |
US20210355129A1 (en) | 2021-11-18 |
AR117188A1 (es) | 2021-07-21 |
CA3118387A1 (en) | 2020-05-07 |
CL2021001116A1 (es) | 2021-11-05 |
IL282587A (en) | 2021-06-30 |
MX2021004987A (es) | 2021-06-15 |
WO2020089459A1 (en) | 2020-05-07 |
SG11202104126UA (en) | 2021-05-28 |
AU2019370735A1 (en) | 2021-05-27 |
ECSP21031082A (es) | 2021-05-31 |
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