AR116946A1 - Derivados de urea 6,7-dihidro-4h-pirazolo[4,3-c]piridinas activas contra el virus de la hepatitis b (vhb) - Google Patents

Derivados de urea 6,7-dihidro-4h-pirazolo[4,3-c]piridinas activas contra el virus de la hepatitis b (vhb)

Info

Publication number
AR116946A1
AR116946A1 ARP190103178A ARP190103178A AR116946A1 AR 116946 A1 AR116946 A1 AR 116946A1 AR P190103178 A ARP190103178 A AR P190103178A AR P190103178 A ARP190103178 A AR P190103178A AR 116946 A1 AR116946 A1 AR 116946A1
Authority
AR
Argentina
Prior art keywords
pirazolo
dihidro
hbv
pyridines
hepatitis
Prior art date
Application number
ARP190103178A
Other languages
English (en)
Inventor
Jasper Springer
Susanne Bonsmann
Andreas Urban
Alastair Donald
Original Assignee
Aicuris Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg
Publication of AR116946A1 publication Critical patent/AR116946A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Abstract

Reivindicación 1: Compuesto de fórmula (1) en la que R¹ es fenilo o piridilo, opcionalmente sustituido una vez, dos veces o tres veces con halógeno, alquilo C₁₋₄, cicloalquilo C₃₋₆, haloalquilo C₁₋₄ o C&
ARP190103178A 2018-11-02 2019-10-31 Derivados de urea 6,7-dihidro-4h-pirazolo[4,3-c]piridinas activas contra el virus de la hepatitis b (vhb) AR116946A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18000874 2018-11-02

Publications (1)

Publication Number Publication Date
AR116946A1 true AR116946A1 (es) 2021-06-30

Family

ID=64362284

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP190103178A AR116946A1 (es) 2018-11-02 2019-10-31 Derivados de urea 6,7-dihidro-4h-pirazolo[4,3-c]piridinas activas contra el virus de la hepatitis b (vhb)

Country Status (14)

Country Link
US (1) US20220009922A1 (es)
EP (1) EP3873899A1 (es)
JP (1) JP2022512873A (es)
KR (1) KR20210098984A (es)
CN (1) CN112969702A (es)
AR (1) AR116946A1 (es)
AU (1) AU2019373677B2 (es)
CA (1) CA3118379A1 (es)
EA (1) EA202191220A1 (es)
IL (1) IL282687A (es)
SG (1) SG11202104080UA (es)
TW (1) TW202031655A (es)
UY (1) UY38439A (es)
WO (1) WO2020089452A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR117188A1 (es) * 2018-11-02 2021-07-21 Aicuris Gmbh & Co Kg Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (vhb)

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19817264A1 (de) 1998-04-18 1999-10-21 Bayer Ag Neue Dihydropyrimidine
WO2000058302A1 (de) 1999-03-25 2000-10-05 Bayer Aktiengesellschaft Dihydropyrimidine und ihre verwendung zur behandlung von hepatitis b
ES2283299T3 (es) 1999-04-23 2007-11-01 Extenday Ip Limited Componente de sujecion y de anclaje de cubrimientos.
AU3009801A (en) 1999-12-22 2001-07-03 Bayer Aktiengesellschaft Combinations of medicaments for treating viral diseases
US20060100233A1 (en) 2002-07-25 2006-05-11 Manuela Villa Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
WO2006033995A2 (en) 2004-09-16 2006-03-30 Valeant Research And Development Thiazolidin-4-ones having anti-hepatitis b activity
CN106166157B (zh) 2011-07-01 2019-08-02 巴鲁·S·布隆伯格研究所 作为防乙型肝炎病毒感染的抗病毒剂的氨磺酰苯甲酰胺衍生物
TWI519515B (zh) 2011-12-21 2016-02-01 諾維拉治療公司 Ｂ型肝炎抗病毒劑
US9233933B2 (en) 2012-01-06 2016-01-12 Janssen Sciences Ireland Uc 4,4-disubstituted-1,4-dihydropyrimidines and the use thereof as medicaments for the treatment of hepatitis B
EA026957B1 (ru) 2012-08-28 2017-06-30 Янссен Сайенсиз Айрлэнд Юси Конденсированные бициклические производные сульфамоила и их применение в качестве лекарственных препаратов для лечения гепатита b
EA027280B1 (ru) 2012-08-28 2017-07-31 Янссен Сайенсиз Айрлэнд Юси Сульфамоил-ариламиды и их применение в качестве лекарственных препаратов для лечения гепатита b
US8993771B2 (en) 2013-03-12 2015-03-31 Novira Therapeutics, Inc. Hepatitis B antiviral agents
CN105209470B (zh) 2013-05-17 2018-02-06 豪夫迈·罗氏有限公司 用于治疗和预防乙型肝炎病毒感染的6‑桥连的杂芳基二氢嘧啶
BR112015028538A2 (pt) 2013-05-17 2017-07-25 Janssen Sciences Ireland Uc derivados de sulfamoiltiofenamida e o uso dos mesmos como medicamentos para o tratamento da hepatite b
NO3024819T3 (es) 2013-07-25 2018-07-21
CA2927560A1 (en) 2013-10-18 2015-04-23 Indiana University Research And Technology Corporation Hepatitis b viral assembly effectors
JP6490686B2 (ja) 2013-11-14 2019-03-27 ノヴィラ・セラピューティクス・インコーポレイテッド アゼパン誘導体及びｂ型肝炎感染の治療方法
US9169212B2 (en) 2014-01-16 2015-10-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
JPWO2015133428A1 (ja) 2014-03-06 2017-04-06 株式会社テイエルブイ 蒸気システム
PT3114128T (pt) 2014-03-07 2019-02-27 Hoffmann La Roche Novas heteroarildihidropirimidinas fundidas em 6 para o tratamento e profilaxia da infeção pelo vírus da hepatite b.
DK3116316T3 (da) 2014-03-13 2019-08-19 Univ Indiana Res & Tech Corp Allosteriske modulatorer af hepatitis b-kerneprotein
MX2016012573A (es) 2014-03-28 2018-02-19 Sunshine Lake Pharma Co Ltd Compuestos de dihidropirimidina y su aplicacion en productos farmaceuticos.
EP3139954A4 (en) 2014-05-09 2018-02-28 Indiana University Research and Technology Corporation Methods and compositions for treating hepatitis b virus infections
CA2952541C (en) 2014-08-14 2019-10-01 F. Hoffmann-La Roche Ag Pyridazones and triazinones for the treatment and prophylaxis of hepatitis b virus infection
DK3227262T3 (da) 2014-12-02 2020-08-10 Novira Therapeutics Inc Sulfidalkyl og pyridyl-revers-sulfonamidforbindelser til hbv-behandling
US9550779B2 (en) 2014-12-30 2017-01-24 Novira Therapeutics, Inc. Derivatives and methods of treating hepatitis B infections
MA41338B1 (fr) 2015-01-16 2019-07-31 Hoffmann La Roche Composés de pyrazine pour le traitement de maladies infectieuses
KR20220020412A (ko) 2015-03-16 2022-02-18 에프. 호프만-라 로슈 아게 Tlr7 작용제 및 hbv 캡시드 조립 억제제를 사용하는 병용 치료
WO2016161268A1 (en) 2015-04-01 2016-10-06 Enanta Pharmaceuticals, Inc. Hepatitis b antviral agents
WO2016177655A1 (en) 2015-05-04 2016-11-10 F. Hoffmann-La Roche Ag Tetrahydropyridopyrimidines and tetrahydropyridopyridines as inhibitors of hbsag (hbv surface antigen) and hbv dna production for the treatment of hepatitis b virus infections
WO2016183266A1 (en) 2015-05-13 2016-11-17 Enanta Pharmaceuticals, Inc. Ehpatitis b antiviral agents
US10875876B2 (en) 2015-07-02 2020-12-29 Janssen Sciences Ireland Uc Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
WO2017011552A1 (en) 2015-07-13 2017-01-19 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
JP6598974B2 (ja) 2015-07-21 2019-10-30 エフ．ホフマン−ラ ロシュ アーゲー Ｂ型肝炎ウイルス感染症の治療および予防のための新規な三環式４−ピリドン−３−カルボン酸誘導体
WO2017015451A1 (en) 2015-07-22 2017-01-26 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
TWI730985B (zh) 2015-09-15 2021-06-21 美商艾森伯利生物科學公司 B型肝炎核心蛋白質調節劑
EP3356328A1 (en) 2015-09-29 2018-08-08 Novira Therapeutics, Inc. Crystalline forms of a hepatitis b antiviral agent
CN108431004B (zh) * 2015-10-23 2021-02-12 武田药品工业株式会社 杂环化合物
US10253030B2 (en) 2015-11-04 2019-04-09 Qilu Pharmaceutical Co., Ltd. Crystal form, preparation method and intermediate of dihydropyrido ring compound
US10280175B2 (en) 2016-02-02 2019-05-07 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
JP6904970B2 (ja) 2016-03-07 2021-07-21 エナンタ ファーマシューティカルズ インコーポレイテッド Ｂ型肝炎抗ウイルス剤
WO2017198744A1 (en) 2016-05-20 2017-11-23 F. Hoffmann-La Roche Ag Novel pyrazine compounds with oxygen, sulfur and nitrogen linker for the treatment of infectious diseases
CN109641896B (zh) * 2016-06-29 2021-09-21 诺维拉治疗公司 二氮杂酮衍生物及其在治疗乙型肝炎感染中的用途
TW201806956A (zh) * 2016-06-29 2018-03-01 諾維拉治療公司 二氮呯酮衍生物及治療ｂ型肝炎感染之方法
WO2018011160A1 (en) 2016-07-14 2018-01-18 F. Hoffmann-La Roche Ag 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazine compounds for the treatment of infectious diseases
EP3484886B1 (en) 2016-07-14 2020-03-04 Hoffmann-La Roche AG 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazine and 6,7-dihydro-4h-triazolo[1,5-a]pyrazine compounds for the treatment of infectious diseases
EP3484885B1 (en) 2016-07-14 2020-03-04 H. Hoffnabb-La Roche Ag Carboxy 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazine compounds for the treatment of infectious diseases
JOP20190024A1 (ar) 2016-08-26 2019-02-19 Gilead Sciences Inc مركبات بيروليزين بها استبدال واستخداماتها
CA3036245C (en) 2016-09-13 2021-07-20 Arbutus Biopharma Corporation Substituted chromane-8-carboxamide compounds and analogues thereof, and methods using same
CA3055194A1 (en) 2017-03-02 2018-09-07 Assembly Biosciences, Inc. Cyclic sulfamide compounds and methods of using same
WO2018172852A1 (en) 2017-03-21 2018-09-27 Arbutus Biopharma Corporation Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same

Also Published As

Publication number Publication date
IL282687A (en) 2021-06-30
SG11202104080UA (en) 2021-05-28
TW202031655A (zh) 2020-09-01
AU2019373677A1 (en) 2021-05-27
UY38439A (es) 2020-05-29
KR20210098984A (ko) 2021-08-11
EA202191220A1 (ru) 2021-07-29
CA3118379A1 (en) 2020-05-07
AU2019373677B2 (en) 2022-03-31
WO2020089452A1 (en) 2020-05-07
CN112969702A (zh) 2021-06-15
JP2022512873A (ja) 2022-02-07
US20220009922A1 (en) 2022-01-13
EP3873899A1 (en) 2021-09-08

Similar Documents

Publication Publication Date Title
AR117188A1 (es) Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (vhb)
EA201892034A1 (ru) Элиминация вируса гепатита в при помощи противовирусных агентов
CL2016001811A1 (es) Compuestos heterociclos derivados de 3-(azepan-1-il-sulfonil)-n-fenilbenzamida; composición farmacéutica, útiles para tratar y prevenir la infección por vhb
NZ729150A (en) Antiretroviral agents
NZ631738A (en) (hetero) arylacetamide derivatives as antiretroviral agents
BR112015021027A2 (pt) compostos terapêuticos
EA201890731A1 (ru) Модуляторы корового белка гепатита b
BR112017002970A2 (pt) novas piridazonas e triazinonas para o tratamento e profilaxia da infecção pelo vírus da hepatite b
AR101586A1 (es) Derivados heterocíclicos con sustituyentes que contienen azufre activos como plaguicidas
EA201791815A1 (ru) Конденсированные гетероциклические соединения и пестициды
SG10201803698UA (en) Novel antiviral agents against hbv infection
EA202091114A1 (ru) Новые высокоактивные пиразолопиперидин-замещенные индол-2-карбоксамиды, активные против вируса гепатита в (hbv)
RS54208B1 (en) NEMATOCIDE SULFONAMIDES
GEP20227373B (en) Novel, highly active amino-thiazole substituted indole-2-carboxamides active against the hepatitis b virus (hbv)
AR097245A1 (es) Derivado de pirazolilpirazol sustituido y su empleo como herbicida
BR112015021768A2 (pt) inibidores do vírus da hepatite c
AR097252A1 (es) Derivado de pirazolilpirazol sustituido y el uso del mismo como herbicida
AR100439A1 (es) Derivados de carboxamida
AR098965A1 (es) Derivados de sulfonamidas tricíclicas
WO2014152716A8 (en) Substituted heterocyclic compounds for treating or preventing viral infections
MX2016005324A (es) Composiciones pesticidas y metodos relacionados.
AR116946A1 (es) Derivados de urea 6,7-dihidro-4h-pirazolo[4,3-c]piridinas activas contra el virus de la hepatitis b (vhb)
AR111672A1 (es) Derivados heterocíclicos con sustituyentes que contienen azufre activos como plaguicidas
DK3820849T3 (da) Phenyl/pyridyl-nh-phenyl/pyridyl-derivater til behandling af rna-virusinfektion
WO2017161133A8 (en) N-hydroxyisoquinolinedione inhibitors of hbv replication