SG11201908569QA - Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same - Google Patents

Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same

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Publication number
SG11201908569QA
SG11201908569QA SG11201908569QA SG11201908569QA SG 11201908569Q A SG11201908569Q A SG 11201908569QA SG 11201908569Q A SG11201908569Q A SG 11201908569QA SG 11201908569Q A SG11201908569Q A SG 11201908569QA
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Singapore
Prior art keywords
co7d
international
pct
rule
same
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Inventor
Andrew Cole
Bruce Dorsey
Ramesh Kakarla
Steven Kultgen
Jorge Quintero
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Arbutus Biopharma Corp
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Application filed by Arbutus Biopharma Corp filed Critical Arbutus Biopharma Corp
Publication of SG11201908569QA publication Critical patent/SG11201908569QA/en

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    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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Abstract

Filing Language: (26) Publication Language: (30) Priority Data: 62/474,263 62/588,711 20 March 2018 (20.03.2018) English English 21 March 2017 (21.03.2017) US 20 November 2017 (20.11.2017) US (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 27 September 2018 (27.09.2018) WIPO I PCT omit VIII °nolo VIII 1111101 ois (10) International Publication Number WO 2018/172852 Al (51) International Patent Classification: C07C 275/26 (2006.01) CO7D 235/02 (2006.01) A61K 31/17 (2006.01) CO7D 239/42 (2006.01) A61K 31/27 (2006.01) CO7D 275/06 (2006.01) A61K 31/33 (2006.01) CO7D 307/82 (2006.01) A61P 31/20 (2006.01) CO7D 333/54 (2006.01) CO7C 271/24 (2006.01) CO7D 401/06 (2006.01) CO7D 213/30 (2006.01) CO7D 401/12 (2006.01) CO7D 213/40 (2006.01) CO7D 405/12 (2006.01) CO7D 221/04 (2006.01) CO7D 409/12 (2006.01) (21) International Application Number: PCT/IB2018/000387 (22) International Filing Date: UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (71) Applicant: ARBUTUS BIOPHARMA CORPO- RATION [CA/CA]; 100-8900 Glenlyon Parkway, Burna- by, BC V5J5J8 (CA). = (72) Inventors: COLE, Andrew, G.; 65 Rocky Brook Road, Cranbury, NJ 08512 (US). DORSEY, Bruce, D.; 1213 Meetinghouse Road, Ambler, PA 19002 (US). KAKAR- LA, Ramesh; 5008 Grundy Way, Doylestown, PA 18902 (US). KULTGEN, Steven; 261 Evergreen Avenue, Apt. A, Hamilton, NJ 08619 (US). QUINTERO, Jorge; 68 White- head Avenue, Sayreville, NJ 08872 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, 1-1 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, In (54) Title: '* 1 : SAME N 00 O O SUBSTITUTED DIHYDROINDENE-4-CARBOXAMIDES AND ANALOGS THEREOF, AND METHODS USING (57) : The present invention includes novel substituted bicyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient. In certain embodiments, the compounds and compositions of the invention are capsid inhibitors. (Formula I)
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Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2020004839A (en) 2017-11-02 2020-10-16 Aicuris Gmbh & Co Kg Novel, highly active amino-thiazole substituted indole-2-carboxamides active against the hepatitis b virus (hbv).
WO2019086142A1 (en) 2017-11-02 2019-05-09 Aicuris Gmbh & Co. Kg Novel, highly active pyrazolo-piperidine substituted indole-2-carboxamides active against the hepatitis b virus (hbv)
WO2020046941A1 (en) * 2018-08-28 2020-03-05 Arbutus Biopharma Corporation Crystalline forms of substituted dihydroindene-4-carboxamide compounds and methods of preparing and using same
AR116946A1 (en) 2018-11-02 2021-06-30 Aicuris Gmbh & Co Kg DERIVATIVES OF UREA 6,7-DIHIDRO-4H-PIRAZOLO [4,3-C] PYRIDINES ACTIVE AGAINST THE VIRUS OF HEPATITIS B (HBV)
UY38436A (en) 2018-11-02 2020-05-29 Aicuris Gmbh & Co Kg NEW 6,7-DIHYDRO-4H-PYRAZOLE [1,5-A] PYRAZININDOL-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)
AR116948A1 (en) 2018-11-02 2021-06-30 Aicuris Gmbh & Co Kg DERIVATIVES OF UREA 6,7-DIHIDRO-4H-PIRAZOLO [1,5-A] PYRAZINES ACTIVE AGAINST THE VIRUS OF HEPATITIS B (HBV)
AR117189A1 (en) 2018-11-02 2021-07-21 Aicuris Gmbh & Co Kg DERIVATIVES OF 6,7-DIHIDRO-4H-PIRAZOLO [1,5-A] PIRAZIN INDOL-2-CARBOXAMIDAS ACTIVE AGAINST THE VIRUS OF HEPATITIS B (HBV)
AU2019373679A1 (en) 2018-11-02 2021-05-27 Aicuris Gmbh & Co. Kg Novel urea 6,7-dihydro-4H-thiazolo(5,4-c)pyridines active against the hepatitis B virus (HBV)
UY38437A (en) 2018-11-02 2020-05-29 Aicuris Gmbh & Co Kg NEW UREA 6,7-DIHIDRO-4H-PIRAZOLO [1,5-A] PYRAZINES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)
EP3962912A1 (en) 2019-04-30 2022-03-09 AiCuris GmbH & Co. KG Novel phenyl and pyridyl ureas active against the hepatitis b virus (hbv)
CA3138643A1 (en) 2019-04-30 2020-11-05 Aicuris Gmbh & Co. Kg Novel indole-2-carboxamides active against the hepatitis b virus (hbv)
AU2020266258A1 (en) 2019-04-30 2021-12-23 Aicuris Gmbh & Co. Kg Novel oxalyl piperazines active against the hepatitis B virus (HBV)
AU2020265392A1 (en) 2019-04-30 2021-12-23 Aicuris Gmbh & Co. Kg Novel indolizine-2-carboxamides active against the hepatitis B virus (HBV)
CN111004211B (en) * 2019-12-29 2021-04-02 苏州诚和医药化学有限公司 Synthetic method of brexpiprazole intermediate 4-bromobenzo [ b ] thiophene
TW202214585A (en) * 2020-06-08 2022-04-16 加拿大商愛彼特生物製藥公司 Substituted isoquinolinylmethyl amides, analogues thereof, and methods using same
CN113801053B (en) * 2021-11-01 2023-09-08 上海皓鸿生物医药科技有限公司 Method for preparing 7-fluoro-2-oxoindoline-4-carboxylic acid

Family Cites Families (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3968163A (en) * 1974-08-19 1976-07-06 Marion Laboratories, Inc. Preparation of 4 and 5-methylindanes
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4160452A (en) 1977-04-07 1979-07-10 Alza Corporation Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
ES2051843T3 (en) * 1987-05-11 1994-07-01 Ono Pharmaceutical Co A PROCESS FOR THE PREPARATION OF A DERIVATIVE OF BENZOILAMINOFENOXIBUTANICO ACID.
US5007790A (en) 1989-04-11 1991-04-16 Depomed Systems, Inc. Sustained-release oral drug dosage form
US5169645A (en) 1989-10-31 1992-12-08 Duquesne University Of The Holy Ghost Directly compressible granules having improved flow properties
DK0632720T3 (en) 1992-03-25 1999-07-26 Depomed Inc Hydroxyethyl cellulose based depot dosage forms
US5582837A (en) 1992-03-25 1996-12-10 Depomed, Inc. Alkyl-substituted cellulose-based sustained-release oral drug dosage forms
FR2732681B1 (en) * 1995-04-05 1997-07-04 Rhone Poulenc Rorer Sa 10H-IMIDAZO (1,2-A) INDENO (1,2-E) PYRAZIN-4-ONE DERIVATIVES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM
AU3290397A (en) 1996-06-10 1998-01-07 Depomed, Inc. Gastric-retentive oral controlled drug delivery system with enhanced retention properties
US5972389A (en) 1996-09-19 1999-10-26 Depomed, Inc. Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter
AU5923998A (en) 1997-01-31 1998-08-25 Avid Therapeutics Inc. 2-benzoylamino-3-phenylpropenamide derivatives and methods of using the same
ES2248908T7 (en) 1997-06-06 2014-11-24 Depomed, Inc. Dosage forms of drugs orally and gastric retention for continued release of highly soluble drugs
US6635280B2 (en) 1997-06-06 2003-10-21 Depomed, Inc. Extending the duration of drug release within the stomach during the fed mode
US6323219B1 (en) 1998-04-02 2001-11-27 Ortho-Mcneil Pharmaceutical, Inc. Methods for treating immunomediated inflammatory disorders
AU5925500A (en) * 1999-07-09 2001-01-30 Picower Institute For Medical Research, The Pyrazolopyrimidinone derivatives conjugated to thiophene moieties or benzo [fused] 5-membered heterocycles for erectile dysfunction
EA005373B1 (en) 1999-08-12 2005-02-24 Фармация Италия С.П.А. Amino-pyrazole derivatives, process for their preparation and their use as antitumor agents
CA2389236A1 (en) 1999-11-02 2001-05-10 Depomed, Inc. Pharmacological inducement of the fed mode for enhanced drug administration to the stomach
ATE340563T1 (en) 2000-02-04 2006-10-15 Depomed Inc SHELL AND CORE TYPE DOSAGE FORM WITH A RELEASE OF ACTIVE INGREDIENTS APPROACHING TO THE ZERO ORDER
US6488962B1 (en) 2000-06-20 2002-12-03 Depomed, Inc. Tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms
US6451808B1 (en) 2000-10-17 2002-09-17 Depomed, Inc. Inhibition of emetic effect of metformin with 5-HT3 receptor antagonists
JP2002161084A (en) 2000-11-28 2002-06-04 Sumitomo Pharmaceut Co Ltd Heterocyclic derivative
KR20040020056A (en) 2001-05-29 2004-03-06 디포메드 디벨롭먼트 리미티드 Method of treating gastroesophageal reflux disease and nocturnal acid breakthrough
WO2003030937A1 (en) 2001-10-05 2003-04-17 Ono Pharmaceutical Co., Ltd. Remedies for stress diseases comprising mitochondrial benzodiazepine receptor antagonists
US6723340B2 (en) 2001-10-25 2004-04-20 Depomed, Inc. Optimal polymer mixtures for gastric retentive tablets
US20030091630A1 (en) 2001-10-25 2003-05-15 Jenny Louie-Helm Formulation of an erodible, gastric retentive oral dosage form using in vitro disintegration test data
CA2409552A1 (en) 2001-10-25 2003-04-25 Depomed, Inc. Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract
TWI312285B (en) 2001-10-25 2009-07-21 Depomed Inc Methods of treatment using a gastric retained gabapentin dosage
WO2003035039A1 (en) 2001-10-25 2003-05-01 Depomed, Inc. Methods of treatment using a gastric retained losartan dosage
US6682759B2 (en) 2002-02-01 2004-01-27 Depomed, Inc. Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs
TWI263497B (en) * 2002-03-29 2006-10-11 Lilly Co Eli Pyridinoylpiperidines as 5-HT1F agonists
US7534894B2 (en) 2003-09-25 2009-05-19 Wyeth Biphenyloxy-acids
EP1804786A4 (en) * 2004-09-29 2008-01-02 Cytovia Inc Substituted n-aryl-9-oxo-9h-fluorene-1-carboxamides and analogs as activators of caspases and inducers of apoptosis
US20070054916A1 (en) * 2004-10-01 2007-03-08 Amgen Inc. Aryl nitrogen-containing bicyclic compounds and methods of use
US7776869B2 (en) * 2004-10-18 2010-08-17 Amgen Inc. Heteroaryl-substituted alkyne compounds and method of use
WO2006070202A1 (en) 2004-12-30 2006-07-06 Astex Therapeutics Limited Pyrazole derivatives having kinase modulating activity
WO2006120178A1 (en) 2005-05-11 2006-11-16 Novo Nordisk A/S New haloalkylsulfone substituted compounds useful for treating obesity and diabetes
ATE503756T1 (en) 2005-09-29 2011-04-15 Glaxo Group Ltd PYRAZOLOA3,4-BUPYRIDINE COMPOUNDS AND THEIR USE AS PDE4 INHIBITORS
CA2627306A1 (en) * 2005-11-01 2007-05-10 Transtech Pharma, Inc. Pharmaceutical use of substituted amides
WO2007076474A1 (en) * 2005-12-23 2007-07-05 Kalypsys, Inc. Novel substituted pyridinyloxy and pyrimidinyloxy amides useful as inhibitors of protein kinases
CA2658764A1 (en) 2006-07-20 2008-01-24 Mehmet Kahraman Benzothiophene inhibitors of rho kinase
BRPI0718162A2 (en) * 2006-10-20 2013-11-26 Irm Llc COMPOSITION AND METHODS FOR MODULATING C-KIT AND PDGFR RECEIVERS
EP1939187A1 (en) * 2006-12-20 2008-07-02 Sanofi-Aventis Substituted heteroaryl pyridopyrimidone derivatives
US7951789B2 (en) 2006-12-28 2011-05-31 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of viral infections
MX2009011498A (en) * 2007-04-24 2009-11-10 Shionogi & Co Aminodihydrothiazine derivatives substituted with cyclic groups.
EP1992621A1 (en) * 2007-05-16 2008-11-19 Sanofi-Aventis Heteroarylamide-substituted pyrimidone derivatives for the treatment of neurodegenerative diseases
WO2009072581A1 (en) * 2007-12-05 2009-06-11 Aska Pharmaceutical Co., Ltd. Lactam compound or salt thereof, and ppar activator
ES2401550T3 (en) * 2008-02-28 2013-04-22 Merck Patent Gmbh Protein kinase inhibitors and use thereof
CN101759683B (en) 2008-12-25 2011-12-28 哈尔滨誉衡药业股份有限公司 Preparation method of hydrindene amide compound, medical composition comprising hydrindene amide compound and application thereof as protein kinase inhibitor
FR2941948B1 (en) * 2009-02-12 2013-04-05 Nova Decision AZAINDOLE DERIVATIVES AS INHIBITOR OF ABL KINASE PROTEINS AND SRC
US8816074B2 (en) 2009-11-16 2014-08-26 University of Georgia Foundation, Inc. 2′-fluoro-6′-methylene carbocyclic nucleosides and methods of treating viral infections
CA2784894A1 (en) * 2009-12-23 2011-06-30 Sanofi Indolyl-piperidinyl benzylamines as beta-tryptase inhibitors
HUE034239T2 (en) 2010-03-31 2018-02-28 Gilead Pharmasset Llc Process for the crystallisation of (s)-isopropyl 2-(((s)-(perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate
WO2012024179A1 (en) * 2010-08-18 2012-02-23 Merck Sharp & Dohme Corp. Substituted amide derivatives as dgat-1 inhibitors
CN103889428A (en) 2010-10-04 2014-06-25 肝炎与病毒研究所 Novel inhibitors of secretion of hepatitis b virus antigens
WO2012120398A1 (en) * 2011-03-04 2012-09-13 Pfizer Limited Aryl substituted carboxamide derivatives as trpm8 modulators
US9278910B2 (en) 2011-05-31 2016-03-08 Receptos, Inc. GLP-1 receptor stabilizers and modulators
MX342731B (en) 2011-06-30 2016-10-11 Arrowhead Res Corp Compositions and methods for inhibiting gene expression of hepatitis b virus.
EP2726459B1 (en) 2011-07-01 2019-09-11 Baruch S. Blumberg Institute Sulfamoylbenzamide derivatives as antiviral agents against hbv infection
TWI519515B (en) 2011-12-21 2016-02-01 諾維拉治療公司 Hepatitis b antiviral agents
JP6134338B2 (en) 2012-02-29 2017-05-24 バルーク エス．ブルームバーグ インスティテュート Inhibitors of hepatitis B virus covalently closed circular DNA formation and methods for their use
CN104144924B (en) 2012-03-31 2016-02-24 弗·哈夫曼-拉罗切有限公司 Be used for the treatment of and prevent hepatitis b virus infected 4-methyl-dihydro miazines
US20130267517A1 (en) 2012-03-31 2013-10-10 Hoffmann-La Roche Inc. Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
MX360323B (en) * 2012-04-25 2018-10-29 Raqualia Pharma Inc Pyrrolopyridinone derivatives as ttx-s blockers.
WO2014008214A1 (en) 2012-07-02 2014-01-09 Biogen Idec Ma Inc. Biaryl-containing compounds as inverse agonists of ror-gamma receptors
PT2890683T (en) 2012-08-28 2017-01-17 Janssen Sciences Ireland Uc Fused bicyclic sulfamoyl derivatives and the use thereof as medicaments for the treatment of hepatitis b
BR112015004192B1 (en) 2012-08-28 2021-02-09 Janssen Sciences Ireland Uc sulfamoyl-arylamides, pharmaceutical composition that comprises them and their use in the treatment of hepatitis b
JP6353460B2 (en) 2012-12-06 2018-07-04 バルーク エス．ブランバーグ インスティチュート Functionalized benzamide derivatives as antiviral agents against HBV infection
KR101942151B1 (en) 2012-12-27 2019-01-24 드렉셀유니버시티 Novel antiviral agents against hbv infection
FR3000494B1 (en) * 2012-12-28 2015-08-21 Oribase Pharma NOVEL AZAINDOLE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES
DK2961732T3 (en) 2013-02-28 2017-07-10 Janssen Sciences Ireland Uc SULFAMOYLARYLAMIDS AND USE THEREOF AS MEDICINES TO TREAT HEPATITIS B
US8993771B2 (en) 2013-03-12 2015-03-31 Novira Therapeutics, Inc. Hepatitis B antiviral agents
US9233961B2 (en) * 2013-03-15 2016-01-12 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
WO2014155301A1 (en) * 2013-03-26 2014-10-02 Piramal Enterprises Limited Substituted bicyclic compounds as inhibitors of ezh2
BR112015025052A2 (en) 2013-04-03 2021-07-06 Janssen Sciences Ireland Uc n-phenyl carboxamide derivatives and their use as medicines for the treatment of hepatitis b
JO3603B1 (en) 2013-05-17 2020-07-05 Janssen Sciences Ireland Uc Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
ES2695182T3 (en) 2013-05-17 2019-01-02 Janssen Sciences Ireland Uc Derivatives of sulfamoyl thiophenamide and its use as medicines to treat hepatitis B
SG10201805033XA (en) 2013-07-25 2018-07-30 Janssen Sciences Ireland Uc Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
NZ717629A (en) 2013-10-23 2021-12-24 Janssen Sciences Ireland Uc Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
WO2015073774A1 (en) 2013-11-14 2015-05-21 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis b infections
US9169212B2 (en) 2014-01-16 2015-10-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
EA201691261A1 (en) 2014-01-30 2016-11-30 Ф. Хоффманн-Ля Рош Аг NEW DIHYDROCHINOLYSINES FOR THE TREATMENT AND PREVENTION OF INFECTION CAUSED BY THE HEPATITIS B VIRUS
CA2932551A1 (en) 2014-02-06 2015-08-13 Janssen Sciences Ireland Uc Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
WO2015134334A1 (en) * 2014-03-03 2015-09-11 Suo Zucai Gemcitabine analogs
CR20160337A (en) 2014-03-07 2016-09-20 Hoffmann La Roche NEW HETEROARILDIHYDROPIRIMIDINES 6-FUSIONATED FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
ES2748029T3 (en) 2014-03-13 2020-03-12 Univ Indiana Res & Tech Corp Allosteric modulators of hepatitis B core protein
CA2948080A1 (en) 2014-05-13 2015-11-19 F. Hoffmann-La Roche Ag Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection
US9938301B2 (en) 2014-05-30 2018-04-10 Qilu Pharmaceutical Co., Ltd. Dihydropyrimido fused ring derivative as HBV inhibitor
JP6506836B2 (en) 2014-08-14 2019-04-24 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Novel pyridazones and triazinones for the treatment and prevention of hepatitis B virus infection
US9637485B2 (en) 2014-11-03 2017-05-02 Hoffmann-La Roche Inc. 6,7-dihydrobenzo[a]quinolizin-2-one derivatives for the treatment and prophylaxis of hepatitis B virus infection
CN107406378A (en) 2014-12-02 2017-11-28 诺维拉治疗公司 Alkyl monosulfide compound and the trans sulfonamide compounds of pyridines for HBV treatments
JP6506845B2 (en) 2014-12-30 2019-04-24 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Novel tetrahydropyridopyrimidines and tetrahydropyridopyridines for the treatment and prevention of hepatitis B virus infection
EP3256471B1 (en) 2015-02-11 2018-12-12 F. Hoffmann-La Roche AG Novel 2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection
JP6462155B2 (en) 2015-05-04 2019-01-30 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Tetrahydropyridopyrimidines and tetrahydropyridopyridines as inhibitors of HBsAg (HBV surface antigen) and HBV DNA production for the treatment of hepatitis B virus infection
WO2016183266A1 (en) 2015-05-13 2016-11-17 Enanta Pharmaceuticals, Inc. Ehpatitis b antiviral agents
CA2991049A1 (en) 2015-07-02 2017-01-05 Valent U.S.A. Llc Compositions for powdery mildew control and methods of their use
US9844221B2 (en) 2015-07-02 2017-12-19 Valent U.S.A. Corporation Methods for apple scab control
WO2017011552A1 (en) 2015-07-13 2017-01-19 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
CN107849037B (en) 2015-07-21 2020-04-17 豪夫迈·罗氏有限公司 Tricyclic 4-pyridone-3-carboxylic acid derivatives for the treatment and prevention of hepatitis B virus infection
WO2017015451A1 (en) 2015-07-22 2017-01-26 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
WO2017016960A1 (en) 2015-07-24 2017-02-02 F. Hoffmann-La Roche Ag Process for the preparation of (6s)-6-alkyl-10-alkoxy-9-(substituted alkoxy)-2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid analogues
WO2017016921A1 (en) 2015-07-24 2017-02-02 F. Hoffmann-La Roche Ag New crystalline forms of (6s)-10-methoxy-6-isopropyl-9-(3-methoxypropoxy)-2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid
CN107820496B (en) 2015-07-27 2020-11-03 豪夫迈·罗氏有限公司 Tetracyclic 4-oxo-pyridine-3-carboxylic acid derivatives for the treatment and prevention of hepatitis B virus infections
CN107835813B (en) 2015-07-28 2020-04-24 豪夫迈·罗氏有限公司 6, 7-dihydropyrido [2,1-a ] phthalazin-2-ones for the treatment and prevention of hepatitis b virus infections
TW201720802A (en) 2015-09-15 2017-06-16 艾森伯利生物科學公司 Hepatitis B core protein modulators
WO2017064156A1 (en) 2015-10-16 2017-04-20 F. Hoffmann-La Roche Ag Novel 6-fused and 2-heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
WO2017102648A1 (en) 2015-12-15 2017-06-22 F. Hoffmann-La Roche Ag Combination therapy of an hbsag inhibitor and a nucleos(t)ide analogue
WO2017108630A1 (en) 2015-12-21 2017-06-29 F. Hoffmann-La Roche Ag Combination therapy of an hbsag inhibitor and an hbv capsid assembly inhibitor
WO2017114812A1 (en) 2015-12-29 2017-07-06 F. Hoffmann-La Roche Ag Combination therapy of an hbsag inhibitor and an interferon
AU2017219216B2 (en) 2016-02-19 2019-12-19 Novartis Ag Tetracyclic pyridone compounds as antivirals

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