SG11201806480UA - Derivatives of pyrroloimidazole or analogues thereof which are useful for the treatment of inter alia cancer - Google Patents
Derivatives of pyrroloimidazole or analogues thereof which are useful for the treatment of inter alia cancerInfo
- Publication number
- SG11201806480UA SG11201806480UA SG11201806480UA SG11201806480UA SG11201806480UA SG 11201806480U A SG11201806480U A SG 11201806480UA SG 11201806480U A SG11201806480U A SG 11201806480UA SG 11201806480U A SG11201806480U A SG 11201806480UA SG 11201806480U A SG11201806480U A SG 11201806480UA
- Authority
- SG
- Singapore
- Prior art keywords
- emcure
- bhosari
- pune
- house
- international
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/134555 Al 10 August 2017 (10.08.2017) WIPO I PCT (51) International Patent Classification: C07D 487/04 (2006.01) A61P 35/00 (2006.01) A61K 31/407 (2006.01) (21) International Application Number: PCT/IB2017/050507 (22) International Filing Date: 31 January 2017 (31.01.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 201621003596 2 February 2016 (02.02.2016) IN 201621024110 14 July 2016 (14.07.2016) IN (71) Applicant: EMCURE PHARMACEUTICALS LIM- ITED [IN/IN]; Emcure House, T-184, M.I.D.C., Bhosari, Pune 411026 (IN). (72) Inventors: GURJAR, Mukund Keshav; Emcure House, T-184, M.I.D.C., Bhosari, Pune 411026 (IN). ROY- CHOWDHURY, Abhijit; Emcure House, T-184, M.I.D.C., Bhosari, Pune 411026 (IN). KHALADKAR, Tushar Pandurang; Emcure House, T-184, M.I.D.C., Bhosari, Pune 411026 (IN). SAWARGAVE, Sangmesh- war Prabhakar; Emcure House, T-184, M.I.D.C., Bhosari, Pune 411026 (IN). JANRAO, Ravindra Ashok; Emcure House, T-184, M.I.D.C., Bhosari, Pune 411026 (IN). KALHAPURE, Vijay Keshav; Emcure House, T- 184, M.I.D.C., Bhosari, Pune 411026 (IN). URUNKAR, Ganesh Devidas; Emcure House, T-184, M.I.D.C., Bhosari, Pune 411026 (IN). GULLAPALLI, Srinivas; Emcure House, T-184, M.I.D.C., Bhosari, Pune 411026 (IN). KULATHINGAL, Jayanarayan; Emcure House, T- 184, M.I.D.C., Bhosari, Pune 411026 (IN). LEKKALA, Rammohan Reddy; Emcure House, T-184, M.I.D.C., Bhosari, Pune 411026 (IN). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, [Continued on next page] (54) Title: DERIVATIVES OF PYRROLOIMIDAZOLE OR ANALOGUES THEREOF WHICH ARE USEFUL FOR THE TREATMENT OF INTER ALIA CANCER 111111 11111111 0 111011111111111 010 11111 01110111 011111111HHIIIIIIIIIIIIIII 0111111 W O 20 17 / 13 4555 Al R2 R3a R 1 R 3 Y 5'Yi / Y4 ,Y2 Y3 (57) : Present invention relates to novel het- erocyclic compounds as indoleamine 2,3-dioxygenase (IDO) and/or tryptophan 2,3-dioxygenase (TDO) mod- ulators. Compounds of the present invention inhibit tryptophan degradation by modulating IDO and/or TDO. Formula (I) The invention further relates to the process of their preparation, pharmaceutical composi- tion and their use in modulating the activity of in- doleamine 2,3-dioxygenase (IDO) and/or tryptophan 2,3- dioxygenase (TDO). The compounds of the inven- tion can be used alone or in combination for the treat- (I) ment of conditions that benefits from the inhibition of tryptophan degradation. WO 2017/134555 Al MUNRO 111111111111111111111111113 0111 01111 R H 111111111011110111111 TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Declarations under Rule 4.17: DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, of inventorship (Rule 4.17(iv)) LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, Published: GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). — with international search report (Art. 21(3))
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN201621003596 | 2016-02-02 | ||
IN201621024110 | 2016-07-14 | ||
PCT/IB2017/050507 WO2017134555A1 (en) | 2016-02-02 | 2017-01-31 | Derivatives of pyrroloimidazole or analogues thereof which are useful for the treatment of inter alia cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201806480UA true SG11201806480UA (en) | 2018-08-30 |
Family
ID=57995249
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201806480UA SG11201806480UA (en) | 2016-02-02 | 2017-01-31 | Derivatives of pyrroloimidazole or analogues thereof which are useful for the treatment of inter alia cancer |
Country Status (8)
Country | Link |
---|---|
US (1) | US20190031665A1 (en) |
EP (1) | EP3400226A1 (en) |
CN (1) | CN109071548A (en) |
AU (1) | AU2017215424A1 (en) |
CA (1) | CA3011677A1 (en) |
PH (1) | PH12018501621A1 (en) |
SG (1) | SG11201806480UA (en) |
WO (1) | WO2017134555A1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7110325B2 (en) * | 2017-08-17 | 2022-08-01 | イドーシア ファーマシューティカルズ リミテッド | Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase |
ES2907282T3 (en) | 2018-01-15 | 2022-04-22 | Idorsia Pharmaceuticals Ltd | Indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase inhibitors |
WO2020092183A1 (en) | 2018-11-01 | 2020-05-07 | Merck Sharp & Dohme Corp. | Novel substituted pyrazole compounds as indoleamine 2,3-dioxygenase inhibitors |
CN110054627B (en) * | 2019-01-10 | 2020-06-30 | 北京华氏开元医药科技有限公司 | Novel IDO inhibitor, preparation method, pharmaceutical composition and application thereof |
CA3146406A1 (en) | 2019-07-11 | 2021-01-14 | Idorsia Pharmaceuticals Ltd | Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase |
US11839659B2 (en) | 2020-07-02 | 2023-12-12 | Northwestern University | Proteolysis-targeting chimeric molecules (PROTACs) that induce degradation of indoleamine 2,3-dioxygenase (IDO) protein |
EP4052705A1 (en) | 2021-03-05 | 2022-09-07 | Universität Basel Vizerektorat Forschung | Compositions for the treatment of ebv associated diseases or conditions |
MX2023010371A (en) | 2021-03-05 | 2024-02-12 | Univ Basel | Compositions for the treatment of ebv associated diseases or conditions. |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5428160A (en) | 1982-12-21 | 1995-06-27 | Ciba-Geigy Corporation | Substituted imidazo[5-a]pyridine derviatives and other substituted bicyclic derivatives |
JPH0971586A (en) | 1995-09-07 | 1997-03-18 | Yamanouchi Pharmaceut Co Ltd | New bicyclic condensed imidazole derivative |
US6420057B1 (en) | 1999-07-05 | 2002-07-16 | Konica Corporation | Organic electroluminescent element |
PT1879573E (en) | 2005-05-10 | 2013-03-25 | Incyte Corp | Modulators of indoleamine 2,3-dioxygenase and methods of using the same |
DE102005053947A1 (en) | 2005-11-11 | 2007-05-16 | Univ Ernst Moritz Arndt | New medicines |
US20110159017A1 (en) | 2008-04-11 | 2011-06-30 | Ludwig Institute For Cancer Research Ltd. | Trytophan catabolism in cancer treatment and diagnosis |
WO2011056652A1 (en) | 2009-10-28 | 2011-05-12 | Newlink Genetics | Imidazole derivatives as ido inhibitors |
NO2694640T3 (en) * | 2011-04-15 | 2018-03-17 | ||
MA38461B1 (en) | 2013-03-14 | 2021-10-29 | Curadev Pharma Private Ltd | Kynurenine pathway inhibitors |
KR20150126623A (en) | 2013-03-14 | 2015-11-12 | 뉴링크 제네틱스 코퍼레이션 | Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization |
BR112015021999A8 (en) | 2013-03-15 | 2019-12-03 | Bristol Myers Squibb Co | indoleamine 2,3-dioxigenase (acid) inhibitors, their uses, pharmaceutical composition, and method for inhibiting indoleamine 2,3-dioxigenase activity |
CN107074859B (en) | 2014-09-05 | 2021-08-06 | 默克专利有限公司 | Cyclohexylethyl substituted diaza-and triaza-tricyclics as indoleamine-2, 3-dioxygenase (IDO) antagonists for the treatment of cancer |
GB201417369D0 (en) | 2014-10-01 | 2014-11-12 | Redx Pharma Ltd | Compounds |
GB201418300D0 (en) | 2014-10-15 | 2014-11-26 | Redx Pharma Ltd | Compounds |
-
2017
- 2017-01-31 AU AU2017215424A patent/AU2017215424A1/en not_active Abandoned
- 2017-01-31 EP EP17704091.2A patent/EP3400226A1/en not_active Withdrawn
- 2017-01-31 US US16/071,712 patent/US20190031665A1/en not_active Abandoned
- 2017-01-31 SG SG11201806480UA patent/SG11201806480UA/en unknown
- 2017-01-31 WO PCT/IB2017/050507 patent/WO2017134555A1/en active Application Filing
- 2017-01-31 CA CA3011677A patent/CA3011677A1/en not_active Abandoned
- 2017-01-31 CN CN201780016108.1A patent/CN109071548A/en active Pending
-
2018
- 2018-07-31 PH PH12018501621A patent/PH12018501621A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2017134555A1 (en) | 2017-08-10 |
PH12018501621A1 (en) | 2019-06-03 |
CN109071548A (en) | 2018-12-21 |
AU2017215424A1 (en) | 2018-08-09 |
US20190031665A1 (en) | 2019-01-31 |
EP3400226A1 (en) | 2018-11-14 |
CA3011677A1 (en) | 2017-08-10 |
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