SG11201806480UA - Derivatives of pyrroloimidazole or analogues thereof which are useful for the treatment of inter alia cancer - Google Patents

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/134555 Al 10 August 2017 (10.08.2017) WIPO I PCT (51) International Patent Classification: C07D 487/04 (2006.01) A61P 35/00 (2006.01) A61K 31/407 (2006.01) (21) International Application Number: PCT/IB2017/050507 (22) International Filing Date: 31 January 2017 (31.01.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 201621003596 2 February 2016 (02.02.2016) IN 201621024110 14 July 2016 (14.07.2016) IN (71) Applicant: EMCURE PHARMACEUTICALS LIM- ITED [IN/IN]; Emcure House, T-184, M.I.D.C., Bhosari, Pune 411026 (IN). (72) Inventors: GURJAR, Mukund Keshav; Emcure House, T-184, M.I.D.C., Bhosari, Pune 411026 (IN). ROY- CHOWDHURY, Abhijit; Emcure House, T-184, M.I.D.C., Bhosari, Pune 411026 (IN). KHALADKAR, Tushar Pandurang; Emcure House, T-184, M.I.D.C., Bhosari, Pune 411026 (IN). SAWARGAVE, Sangmesh- war Prabhakar; Emcure House, T-184, M.I.D.C., Bhosari, Pune 411026 (IN). JANRAO, Ravindra Ashok; Emcure House, T-184, M.I.D.C., Bhosari, Pune 411026 (IN). KALHAPURE, Vijay Keshav; Emcure House, T- 184, M.I.D.C., Bhosari, Pune 411026 (IN). URUNKAR, Ganesh Devidas; Emcure House, T-184, M.I.D.C., Bhosari, Pune 411026 (IN). GULLAPALLI, Srinivas; Emcure House, T-184, M.I.D.C., Bhosari, Pune 411026 (IN). KULATHINGAL, Jayanarayan; Emcure House, T- 184, M.I.D.C., Bhosari, Pune 411026 (IN). LEKKALA, Rammohan Reddy; Emcure House, T-184, M.I.D.C., Bhosari, Pune 411026 (IN). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, [Continued on next page] (54) Title: DERIVATIVES OF PYRROLOIMIDAZOLE OR ANALOGUES THEREOF WHICH ARE USEFUL FOR THE TREATMENT OF INTER ALIA CANCER 111111 11111111 0 111011111111111 010 11111 01110111 011111111HHIIIIIIIIIIIIIII 0111111 W O 20 17 / 13 4555 Al R2 R3a R 1 R 3 Y 5'Yi / Y4 ,Y2 Y3 (57) : Present invention relates to novel het- erocyclic compounds as indoleamine 2,3-dioxygenase (IDO) and/or tryptophan 2,3-dioxygenase (TDO) mod- ulators. Compounds of the present invention inhibit tryptophan degradation by modulating IDO and/or TDO. Formula (I) The invention further relates to the process of their preparation, pharmaceutical composi- tion and their use in modulating the activity of in- doleamine 2,3-dioxygenase (IDO) and/or tryptophan 2,3- dioxygenase (TDO). The compounds of the inven- tion can be used alone or in combination for the treat- (I) ment of conditions that benefits from the inhibition of tryptophan degradation. WO 2017/134555 Al MUNRO 111111111111111111111111113 0111 01111 R H 111111111011110111111 TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Declarations under Rule 4.17: DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, of inventorship (Rule 4.17(iv)) LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, Published: GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). — with international search report (Art. 21(3))