AR112333A1 - Pirrolopirimidina y derivados de pirrolopirimidina - Google Patents

Pirrolopirimidina y derivados de pirrolopirimidina

Info

Publication number
AR112333A1
AR112333A1 ARP180101945A AR112333A1 AR 112333 A1 AR112333 A1 AR 112333A1 AR P180101945 A ARP180101945 A AR P180101945A AR 112333 A1 AR112333 A1 AR 112333A1
Authority
AR
Argentina
Prior art keywords
pyrrolopyrimidine
derivatives
solvate
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
Other languages
English (en)
Original Assignee
Galapagos Nv
Calchan Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galapagos Nv, Calchan Ltd filed Critical Galapagos Nv
Publication of AR112333A1 publication Critical patent/AR112333A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

Reivindicación 1: Un compuesto de acuerdo con la fórmula (1), donde R¹ es H, CH₃, F o Cl; X es N, CH o C-CN; y R² es CH₃ o halógeno; o una sal farmacéuticamente aceptable, o un solvato, o una sal farmacéuticamente aceptable de un solvato de este; o un metabolito biológicamente activo de este.
ARP180101945 2017-07-12 2018-07-12 Pirrolopirimidina y derivados de pirrolopirimidina AR112333A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1711234.3A GB201711234D0 (en) 2017-07-12 2017-07-12 Pyrrolopyrimidine and pyrrolopyridine derivatives

Publications (1)

Publication Number Publication Date
AR112333A1 true AR112333A1 (es) 2019-10-16

Family

ID=59676761

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180101945 AR112333A1 (es) 2017-07-12 2018-07-12 Pirrolopirimidina y derivados de pirrolopirimidina

Country Status (18)

Country Link
US (2) US11136325B2 (es)
EP (1) EP3652173A1 (es)
JP (1) JP7198263B2 (es)
KR (1) KR20200028436A (es)
CN (1) CN111094283A (es)
AR (1) AR112333A1 (es)
AU (1) AU2018300218B2 (es)
BR (1) BR112020000578A2 (es)
CA (1) CA3069358A1 (es)
CO (1) CO2020001346A2 (es)
GB (1) GB201711234D0 (es)
IL (1) IL271910B2 (es)
MX (1) MX2020000005A (es)
PH (1) PH12019502823A1 (es)
SG (1) SG11202000168UA (es)
TW (1) TWI794253B (es)
UY (1) UY37809A (es)
WO (1) WO2019012284A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201711234D0 (en) * 2017-07-12 2017-08-23 Galapagos Nv Pyrrolopyrimidine and pyrrolopyridine derivatives
CN111303155A (zh) * 2020-03-13 2020-06-19 深圳大学 靶向pak1抑制剂及其在抗肿瘤治疗药物中的应用
CN111704617B (zh) * 2020-06-15 2022-08-23 嘉兴特科罗生物科技有限公司 一种小分子化合物
KR102635126B1 (ko) * 2021-05-27 2024-02-13 한국과학기술연구원 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 피롤로피리미딘 유도체 및 이들의 용도
CA3227277A1 (en) * 2021-07-28 2023-02-02 Sundeep Dugar Pyrrolo[2,3-b]pyridine pgdh inhibitors and methods of making and using
WO2023014049A1 (ko) * 2021-08-02 2023-02-09 한국화학연구원 신규한 피롤로 피리미딘 유도체 화합물, 이의 제조방법, 및 이를 유효성분으로 포함하는 대사성 간질환의 예방 또는 치료용 약학적 조성물

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100840727B1 (ko) 1999-12-02 2008-06-23 오에스아이 파마슈티컬스, 인코포레이티드 아데노신 a1, a2a 및 a3 수용체 특이 화합물 및 그의 사용방법
TW200306191A (en) * 2002-02-22 2003-11-16 Teijin Ltd Pyrrolopyrimidine derivatives
AU2003284597A1 (en) 2002-11-22 2004-06-18 Takeda Pharmaceutical Company Limited Apoptosis-associated protein and use thereof
EP2058309A4 (en) 2006-08-04 2010-12-22 Takeda Pharmaceutical CONDENSED HETEROCYCLIC COMPOUND
CA2672373C (en) 2006-12-19 2011-08-30 Pfizer Products Inc. Nicotinamide derivatives as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases
WO2009027283A1 (en) 2007-08-31 2009-03-05 Merck Serono S.A. Triazolopyridine compounds and their use as ask inhibitors
US8461163B2 (en) 2008-03-31 2013-06-11 Takeda Pharmaceutical Company Limited Substituted N-(pyrazolo[1,5-a]pyrimidin-5-yl)amides as inhibitors of apoptosis signal-regulating kinase 1
TWI598347B (zh) * 2009-07-13 2017-09-11 基利科學股份有限公司 調節細胞凋亡信號之激酶的抑制劑
EP2651417B1 (en) * 2010-12-16 2016-11-30 Calchan Limited Ask1 inhibiting pyrrolopyrimidine derivatives
GB201711234D0 (en) * 2017-07-12 2017-08-23 Galapagos Nv Pyrrolopyrimidine and pyrrolopyridine derivatives

Also Published As

Publication number Publication date
WO2019012284A1 (en) 2019-01-17
IL271910A (en) 2020-02-27
JP2020530833A (ja) 2020-10-29
AU2018300218B2 (en) 2021-12-16
BR112020000578A2 (pt) 2020-07-14
US20200165259A1 (en) 2020-05-28
TWI794253B (zh) 2023-03-01
AU2018300218A1 (en) 2020-02-27
RU2020106289A (ru) 2021-08-12
CA3069358A1 (en) 2019-01-17
PH12019502823A1 (en) 2020-10-26
GB201711234D0 (en) 2017-08-23
TW201908312A (zh) 2019-03-01
UY37809A (es) 2019-02-28
IL271910B1 (en) 2023-03-01
IL271910B2 (en) 2023-07-01
US11136325B2 (en) 2021-10-05
JP7198263B2 (ja) 2022-12-28
RU2020106289A3 (es) 2021-11-10
CN111094283A (zh) 2020-05-01
SG11202000168UA (en) 2020-02-27
EP3652173A1 (en) 2020-05-20
KR20200028436A (ko) 2020-03-16
MX2020000005A (es) 2020-08-06
US20220169653A1 (en) 2022-06-02
CO2020001346A2 (es) 2020-05-29

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