EA201791667A1 - Соединения бензоксаборола и их применение - Google Patents

Соединения бензоксаборола и их применение

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Publication number
EA201791667A1
EA201791667A1 EA201791667A EA201791667A EA201791667A1 EA 201791667 A1 EA201791667 A1 EA 201791667A1 EA 201791667 A EA201791667 A EA 201791667A EA 201791667 A EA201791667 A EA 201791667A EA 201791667 A1 EA201791667 A1 EA 201791667A1
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EA
Eurasian Patent Office
Prior art keywords
compounds
application
structure includes
whose structure
includes formula
Prior art date
Application number
EA201791667A
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English (en)
Inventor
М.Р.К. Элли (Дикон)
Дэвид Баррос-Агирре
Илариа Джордано
Винсент Эрнандес
Сяньфэн Ли
Джейкоб Дж. Плэттнер
Original Assignee
Глаксосмитклайн Интеллекчуал Проперти (№2) Лимитед
Анакор Фармасьютикалс, Инк.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55409879&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201791667(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Глаксосмитклайн Интеллекчуал Проперти (№2) Лимитед, Анакор Фармасьютикалс, Инк. filed Critical Глаксосмитклайн Интеллекчуал Проперти (№2) Лимитед
Publication of EA201791667A1 publication Critical patent/EA201791667A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

Предложены соединения, структура которых включает формулу II, или соединение, структура которого включает формулу IIIгде X выбран из хлора, фтора, брома и йода, каждый из Rи Rнезависимо выбран из H, -CH, -CHCH, -CHCHCHили -CH(CH); композиции, содержащие их, их применение в терапии, включая их применение в качестве антимикобактериальных агентов, например в лечении микобактериальной инфекции у млекопитающего, и способы получения таких соединений.
EA201791667A 2015-02-12 2016-02-12 Соединения бензоксаборола и их применение EA201791667A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP15382054 2015-02-12
EP15382055 2015-02-12
EP15382056 2015-02-12
PCT/IB2016/050776 WO2016128949A1 (en) 2015-02-12 2016-02-12 Benzoxaborole compounds and uses thereof

Publications (1)

Publication Number Publication Date
EA201791667A1 true EA201791667A1 (ru) 2018-02-28

Family

ID=55409879

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201791667A EA201791667A1 (ru) 2015-02-12 2016-02-12 Соединения бензоксаборола и их применение
EA201791671A EA036516B1 (ru) 2015-02-12 2016-02-12 4-замещенные соединения бензоксаборола и их применение

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201791671A EA036516B1 (ru) 2015-02-12 2016-02-12 4-замещенные соединения бензоксаборола и их применение

Country Status (35)

Country Link
US (3) US10774096B2 (ru)
EP (2) EP3256480A1 (ru)
JP (2) JP6771472B2 (ru)
KR (2) KR20170117156A (ru)
CN (2) CN107548398A (ru)
AU (3) AU2016217508A1 (ru)
BR (2) BR112017017211B1 (ru)
CA (2) CA2976030C (ru)
CL (2) CL2017002060A1 (ru)
CO (2) CO2017008809A2 (ru)
CR (2) CR20170371A (ru)
CY (1) CY1123687T1 (ru)
DK (1) DK3256479T3 (ru)
DO (2) DOP2017000188A (ru)
EA (2) EA201791667A1 (ru)
ES (1) ES2821951T3 (ru)
HR (1) HRP20201597T1 (ru)
HU (1) HUE051113T2 (ru)
IL (2) IL253865A0 (ru)
LT (1) LT3256479T (ru)
MA (2) MA41494B1 (ru)
MX (2) MX2017010414A (ru)
MY (1) MY194004A (ru)
NZ (1) NZ734379A (ru)
PE (2) PE20171432A1 (ru)
PH (2) PH12017501427A1 (ru)
PL (1) PL3256479T3 (ru)
PT (1) PT3256479T (ru)
RS (1) RS60885B1 (ru)
SG (2) SG11201706510YA (ru)
SI (1) SI3256479T1 (ru)
TW (2) TWI730953B (ru)
UA (1) UA120527C2 (ru)
WO (2) WO2016128948A1 (ru)
ZA (1) ZA201705456B (ru)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20220384T1 (hr) * 2013-08-09 2022-07-22 Glaxosmithkline Intellectual Property (No. 2) Limited Triciklički benzoksaborol spojevi i njihove uporabe
HUE059818T2 (hu) 2017-05-08 2022-12-28 Glaxosmithkline Intellectual Property Dev Szenfetrinem vagy annak sója vagy észtere a mikrobakteriális fertõzés kezelésében való felhasználásra
MX2020005464A (es) 2017-11-30 2020-12-03 Boragen Inc Compuestos de benzoxaborol y formulaciones de los mismos.
EP3836938A4 (en) 2018-08-18 2022-05-11 Boragen, Inc. SOLID FORMS OF SUBSTITUTED BENZOXAZOLE AND COMPOSITIONS THEREOF
CN110441344B (zh) * 2019-06-25 2020-09-29 北京大学 一种基于固体核磁共振技术检测rna结构的方法
WO2023246841A1 (en) * 2022-06-23 2023-12-28 Shanghai Micurx Pharmaceutical Co., Ltd. Methods and uses of boron compounds in the treatment of nontuberculous mycobacterium infections and pharmaceutical compositions for treatment of same
WO2023246842A1 (en) * 2022-06-23 2023-12-28 Shanghai Micurx Pharmaceutical Co., Ltd. Prodrugs of boron compounds and their use in treating bacterial infections

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JO3396B1 (ar) * 2007-06-20 2019-10-20 Anacor Pharmaceuticals Inc جزيئات صغيرة تحتوي على البورون
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HRP20220384T1 (hr) * 2013-08-09 2022-07-22 Glaxosmithkline Intellectual Property (No. 2) Limited Triciklički benzoksaborol spojevi i njihove uporabe

Also Published As

Publication number Publication date
IL253864B (en) 2021-07-29
US20180037595A1 (en) 2018-02-08
SG11201706510YA (en) 2017-09-28
IL253864A0 (en) 2017-09-28
EA036516B1 (ru) 2020-11-18
CO2017008809A2 (es) 2017-11-10
PH12017501428A1 (en) 2018-01-15
CN107548398A (zh) 2018-01-05
ES2821951T3 (es) 2021-04-28
SG11201706511TA (en) 2017-09-28
MA41494B1 (fr) 2020-10-28
JP2018506538A (ja) 2018-03-08
DOP2017000189A (es) 2018-02-15
EP3256479B1 (en) 2020-07-29
CR20170371A (es) 2018-01-22
MX2017010413A (es) 2018-05-11
UA120527C2 (uk) 2019-12-26
PE20171348A1 (es) 2017-09-13
US20180044353A1 (en) 2018-02-15
JP6771472B2 (ja) 2020-10-21
CA2976308A1 (en) 2016-08-18
TW201643173A (zh) 2016-12-16
US20210053996A1 (en) 2021-02-25
BR112017017213A2 (pt) 2018-04-03
MY194004A (en) 2022-11-07
NZ734379A (en) 2023-06-30
JP2018506540A (ja) 2018-03-08
DK3256479T3 (da) 2020-11-02
AU2016217507A1 (en) 2017-09-28
CO2017008816A2 (es) 2017-11-10
US11214582B2 (en) 2022-01-04
CN107531730B (zh) 2020-08-07
KR20170117158A (ko) 2017-10-20
TWI730953B (zh) 2021-06-21
WO2016128948A1 (en) 2016-08-18
AU2016217507B2 (en) 2019-03-14
US10774096B2 (en) 2020-09-15
LT3256479T (lt) 2020-12-28
BR112017017211A2 (pt) 2018-04-03
IL253865A0 (en) 2017-10-31
HRP20201597T1 (hr) 2020-12-25
BR112017017211B1 (pt) 2023-04-25
PT3256479T (pt) 2020-10-22
SI3256479T1 (sl) 2020-11-30
CL2017002059A1 (es) 2018-03-16
PL3256479T3 (pl) 2021-06-14
EP3256479A1 (en) 2017-12-20
ZA201705456B (en) 2019-10-30
CY1123687T1 (el) 2022-03-24
HUE051113T2 (hu) 2021-01-28
AU2020256369A1 (en) 2020-11-12
CR20170372A (es) 2017-10-19
CA2976030A1 (en) 2016-08-18
MA41494A (fr) 2017-12-19
WO2016128949A1 (en) 2016-08-18
RS60885B1 (sr) 2020-11-30
EP3256480A1 (en) 2017-12-20
PH12017501427A1 (en) 2018-01-15
CN107531730A (zh) 2018-01-02
KR20170117156A (ko) 2017-10-20
MX2017010414A (es) 2018-05-11
DOP2017000188A (es) 2017-09-15
TW201702250A (zh) 2017-01-16
CA2976030C (en) 2023-09-26
PE20171432A1 (es) 2017-09-26
EA201791671A1 (ru) 2018-02-28
MA41495A (fr) 2017-12-19
AU2016217508A1 (en) 2017-09-28
CL2017002060A1 (es) 2018-03-16

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