MA41494A - Composés benzoxaborole substitués en position 4 et utilisations associées - Google Patents
Composés benzoxaborole substitués en position 4 et utilisations associéesInfo
- Publication number
- MA41494A MA41494A MA041494A MA41494A MA41494A MA 41494 A MA41494 A MA 41494A MA 041494 A MA041494 A MA 041494A MA 41494 A MA41494 A MA 41494A MA 41494 A MA41494 A MA 41494A
- Authority
- MA
- Morocco
- Prior art keywords
- compounds substituted
- associated uses
- benzoxaborole compounds
- ch2ch2ch3
- ch2ch3
- Prior art date
Links
- GDMJXXLVTYSBBE-UHFFFAOYSA-N 1,2-benzoxaborole Chemical group C1=CC=C2OB=CC2=C1 GDMJXXLVTYSBBE-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010062207 Mycobacterial infection Diseases 0.000 abstract 1
- 239000003926 antimycobacterial agent Substances 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000027531 mycobacterial infectious disease Diseases 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Gynecology & Obstetrics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pregnancy & Childbirth (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
La présente invention concerne des benzoxaboroles substitués dont la structure comprend la formule (iii), dans laquelle r3 est choisi parmi –ch3, –ch2ch3, –ch2=ch2, –ch2ch2ch3, –ch(ch3)2, –ch2ch2=ch2, et un cyclopropyle, r1 et r2 sont chacun indépendamment choisis parmi h, -ch3, -ch2ch3, –ch2ch2ch3, et –ch(ch3)2 ; des compositions contenant de tels composés, leur utilisation en thérapie, y compris leur utilisation comme agents anti-mycobactériens, par exemple dans le traitement d'une infection mycobactérienne chez un mammifère, et des procédés pour la préparation de tels composés.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15382054 | 2015-02-12 | ||
| EP15382056 | 2015-02-12 | ||
| EP15382055 | 2015-02-12 | ||
| PCT/IB2016/050775 WO2016128948A1 (fr) | 2015-02-12 | 2016-02-12 | Composés benzoxaborole substitués en position 4 et utilisations associées |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA41494A true MA41494A (fr) | 2017-12-19 |
| MA41494B1 MA41494B1 (fr) | 2020-10-28 |
Family
ID=55409879
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA41494A MA41494B1 (fr) | 2015-02-12 | 2016-02-11 | Composés benzoxaborole substitués en position 4 et utilisations associées |
| MA041495A MA41495A (fr) | 2015-02-12 | 2016-02-11 | Composés benzoxaborole et leurs utilisations |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA041495A MA41495A (fr) | 2015-02-12 | 2016-02-11 | Composés benzoxaborole et leurs utilisations |
Country Status (35)
| Country | Link |
|---|---|
| US (3) | US10774096B2 (fr) |
| EP (2) | EP3256480A1 (fr) |
| JP (2) | JP2018506540A (fr) |
| KR (2) | KR20170117158A (fr) |
| CN (2) | CN107548398A (fr) |
| AU (3) | AU2016217508A1 (fr) |
| BR (2) | BR112017017211B1 (fr) |
| CA (2) | CA2976308A1 (fr) |
| CL (2) | CL2017002060A1 (fr) |
| CO (2) | CO2017008809A2 (fr) |
| CR (2) | CR20170371A (fr) |
| CY (1) | CY1123687T1 (fr) |
| DK (1) | DK3256479T3 (fr) |
| DO (2) | DOP2017000189A (fr) |
| EA (2) | EA201791667A1 (fr) |
| ES (1) | ES2821951T3 (fr) |
| HR (1) | HRP20201597T1 (fr) |
| HU (1) | HUE051113T2 (fr) |
| IL (2) | IL253864B (fr) |
| LT (1) | LT3256479T (fr) |
| MA (2) | MA41494B1 (fr) |
| MX (2) | MX2017010414A (fr) |
| MY (1) | MY194004A (fr) |
| NZ (1) | NZ734379A (fr) |
| PE (2) | PE20171348A1 (fr) |
| PH (2) | PH12017501428A1 (fr) |
| PL (1) | PL3256479T3 (fr) |
| PT (1) | PT3256479T (fr) |
| RS (1) | RS60885B1 (fr) |
| SG (2) | SG11201706511TA (fr) |
| SI (1) | SI3256479T1 (fr) |
| TW (2) | TWI730953B (fr) |
| UA (1) | UA120527C2 (fr) |
| WO (2) | WO2016128948A1 (fr) |
| ZA (1) | ZA201705456B (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105492388B (zh) * | 2013-08-09 | 2018-12-21 | 葛兰素史克知识产权第二有限公司 | 三环苯并氧杂硼杂环戊烯化合物及其用途 |
| AU2018265192B2 (en) * | 2017-05-08 | 2021-06-17 | Glaxosmithkline Intellectual Property Development Limited | Sanfetrinem or a salt or ester thereof for use in treating mycobacterial infection |
| JP2021505660A (ja) | 2017-11-30 | 2021-02-18 | ボラゲン，インコーポレーテッド | ベンゾキサボロール化合物およびその配合物 |
| EP3836938A4 (fr) | 2018-08-18 | 2022-05-11 | Boragen, Inc. | Formes solides de benzoxaborole substitué et compositions associées |
| CN110441344B (zh) * | 2019-06-25 | 2020-09-29 | 北京大学 | 一种基于固体核磁共振技术检测rna结构的方法 |
| AU2023287202A1 (en) * | 2022-06-23 | 2024-06-06 | Shanghai Micurx Pharmaceutical Co., Ltd. | Methods and uses of boron compounds in the treatment of nontuberculous mycobacterium infections and pharmaceutical compositions for treatment of same |
| EP4384527A1 (fr) * | 2022-06-23 | 2024-06-19 | Micurx Pharmaceuticals, Inc. | Promédicaments de composés de bore et leur utilisation dans le traitement d'infections bactériennes |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9411587D0 (en) * | 1994-06-09 | 1994-08-03 | Zeneca Ltd | Compound, composition and use |
| EP0947498B1 (fr) | 1996-12-02 | 2004-09-15 | Chisso Corporation | Derives de nitro-alcool optiquement actifs, derives d'amino-alcool optiquement actifs et procede de leur preparation |
| CN100384791C (zh) | 2002-12-02 | 2008-04-30 | 索尔维亚斯股份公司 | 碳-杂原子双键的催化氢化 |
| EP2343304B1 (fr) | 2005-02-16 | 2015-06-10 | Anacor Pharmaceuticals, Inc. | Composés boronophthalide biocides |
| US7919422B2 (en) | 2005-03-08 | 2011-04-05 | Agency For Science, Technology And Research | Chiral bisoxazoline catalysts |
| WO2007078340A2 (fr) | 2005-12-30 | 2007-07-12 | Anacor Pharmaceuticals, Inc. | Petites molecules contenant du bore |
| TWM325238U (en) * | 2006-12-29 | 2008-01-11 | Universal Scient Ind Co Ltd | Voltage regulator and voltage regulating system |
| KR100848491B1 (ko) | 2007-01-16 | 2008-07-28 | 영진약품공업주식회사 | 베타아미노기를 갖는 2-싸이아졸리딘 유도체, 이의약학적으로 허용 가능한 염 및 이의 제조 방법 |
| JO3396B1 (ar) | 2007-06-20 | 2019-10-20 | Anacor Pharmaceuticals Inc | جزيئات صغيرة تحتوي على البورون |
| AU2009335744A1 (en) | 2008-12-17 | 2010-07-15 | Anacor Pharmaceuticals, Inc. | Polymorphs of (S)-3-aminomethyl-7-(3-hydroxy-propoxy) -3H-benzo[c][1,2] oxaborol-1-ol |
| US20110124597A1 (en) * | 2009-09-25 | 2011-05-26 | Anacor Pharmaceuticals, Inc. | Boron containing small molecules |
| CN102821609B (zh) * | 2010-04-07 | 2015-03-25 | 葛兰素史密丝克莱恩有限责任公司 | 用于制备苯并氧杂硼杂环戊烯的方法 |
| MX338209B (es) * | 2010-09-07 | 2016-04-07 | Anacor Pharmaceuticals Inc | Derivados de benzoxaborol para tratar infecciones bacterianas. |
| CN104136032B (zh) * | 2011-12-22 | 2018-11-13 | 盟科医药技术公司 | 可用于抗菌治疗的三环类硼化合物 |
| CN102739587B (zh) | 2012-06-16 | 2014-05-21 | 天地融科技股份有限公司 | 音频数据传输方法 |
| KR101636431B1 (ko) | 2013-07-30 | 2016-07-05 | 동아에스티 주식회사 | 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도 |
| CN105492388B (zh) | 2013-08-09 | 2018-12-21 | 葛兰素史克知识产权第二有限公司 | 三环苯并氧杂硼杂环戊烯化合物及其用途 |
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2016
- 2016-02-11 MA MA41494A patent/MA41494B1/fr unknown
- 2016-02-11 MA MA041495A patent/MA41495A/fr unknown
- 2016-02-12 KR KR1020177025539A patent/KR20170117158A/ko not_active Application Discontinuation
- 2016-02-12 CA CA2976308A patent/CA2976308A1/fr not_active Abandoned
- 2016-02-12 PE PE2017001401A patent/PE20171348A1/es not_active Application Discontinuation
- 2016-02-12 SG SG11201706511TA patent/SG11201706511TA/en unknown
- 2016-02-12 US US15/550,693 patent/US10774096B2/en active Active
- 2016-02-12 CN CN201680021488.3A patent/CN107548398A/zh active Pending
- 2016-02-12 RS RS20201204A patent/RS60885B1/sr unknown
- 2016-02-12 JP JP2017542053A patent/JP2018506540A/ja active Pending
- 2016-02-12 CN CN201680021538.8A patent/CN107531730B/zh active Active
- 2016-02-12 DK DK16706002.9T patent/DK3256479T3/da active
- 2016-02-12 HU HUE16706002A patent/HUE051113T2/hu unknown
- 2016-02-12 CA CA2976030A patent/CA2976030C/fr active Active
- 2016-02-12 JP JP2017541999A patent/JP6771472B2/ja active Active
- 2016-02-12 NZ NZ734379A patent/NZ734379A/en unknown
- 2016-02-12 US US15/550,658 patent/US20180037595A1/en not_active Abandoned
- 2016-02-12 CR CR20170371A patent/CR20170371A/es unknown
- 2016-02-12 EA EA201791667A patent/EA201791667A1/ru unknown
- 2016-02-12 SG SG11201706510YA patent/SG11201706510YA/en unknown
- 2016-02-12 MX MX2017010414A patent/MX2017010414A/es unknown
- 2016-02-12 ES ES16706002T patent/ES2821951T3/es active Active
- 2016-02-12 BR BR112017017211-9A patent/BR112017017211B1/pt active IP Right Grant
- 2016-02-12 SI SI201630941T patent/SI3256479T1/sl unknown
- 2016-02-12 WO PCT/IB2016/050775 patent/WO2016128948A1/fr active Application Filing
- 2016-02-12 LT LTEP16706002.9T patent/LT3256479T/lt unknown
- 2016-02-12 CR CR20170372A patent/CR20170372A/es unknown
- 2016-02-12 BR BR112017017213-5A patent/BR112017017213A2/pt not_active Application Discontinuation
- 2016-02-12 PT PT167060029T patent/PT3256479T/pt unknown
- 2016-02-12 EP EP16706003.7A patent/EP3256480A1/fr not_active Withdrawn
- 2016-02-12 EA EA201791671A patent/EA036516B1/ru unknown
- 2016-02-12 PL PL16706002T patent/PL3256479T3/pl unknown
- 2016-02-12 WO PCT/IB2016/050776 patent/WO2016128949A1/fr active Application Filing
- 2016-02-12 MY MYPI2017702943A patent/MY194004A/en unknown
- 2016-02-12 UA UAA201708405A patent/UA120527C2/uk unknown
- 2016-02-12 KR KR1020177025535A patent/KR20170117156A/ko unknown
- 2016-02-12 EP EP16706002.9A patent/EP3256479B1/fr active Active
- 2016-02-12 MX MX2017010413A patent/MX2017010413A/es unknown
- 2016-02-12 AU AU2016217508A patent/AU2016217508A1/en not_active Abandoned
- 2016-02-12 PE PE2017001400A patent/PE20171432A1/es not_active Application Discontinuation
- 2016-02-12 AU AU2016217507A patent/AU2016217507B2/en active Active
- 2016-02-15 TW TW105104376A patent/TWI730953B/zh not_active IP Right Cessation
- 2016-02-15 TW TW105104422A patent/TW201702250A/zh unknown
-
2017
- 2017-08-07 IL IL253864A patent/IL253864B/en unknown
- 2017-08-07 IL IL253865A patent/IL253865A0/en unknown
- 2017-08-09 PH PH12017501428A patent/PH12017501428A1/en unknown
- 2017-08-09 PH PH12017501427A patent/PH12017501427A1/en unknown
- 2017-08-10 DO DO2017000189A patent/DOP2017000189A/es unknown
- 2017-08-10 DO DO2017000188A patent/DOP2017000188A/es unknown
- 2017-08-11 ZA ZA201705456A patent/ZA201705456B/en unknown
- 2017-08-11 CL CL2017002060A patent/CL2017002060A1/es unknown
- 2017-08-11 CL CL2017002059A patent/CL2017002059A1/es unknown
- 2017-08-29 CO CONC2017/0008809A patent/CO2017008809A2/es unknown
- 2017-08-29 CO CONC2017/0008816A patent/CO2017008816A2/es unknown
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2020
- 2020-09-11 US US17/018,301 patent/US11214582B2/en active Active
- 2020-10-07 HR HRP20201597TT patent/HRP20201597T1/hr unknown
- 2020-10-14 AU AU2020256369A patent/AU2020256369A1/en not_active Abandoned
- 2020-10-15 CY CY20201100978T patent/CY1123687T1/el unknown
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| MA34308B1 (fr) | Triazolopyridines substituées | |
| MA34331B1 (fr) | Composés pyrazole comme inhibiteurs du récepteur sigma | |
| MA45888A1 (fr) | Inhibiteurs de tyrosine kinase de bruton | |
| MA53124B1 (fr) | Agents de dégradation sélectifs des récepteurs des oestrogènes | |
| MA35748B1 (fr) | Fluorométhyl-5,6-dihydro-4h-[1,3]oxazines | |
| MA37439B1 (fr) | Inhibiteurs de dgat1 à ponts éthers cycliques pour le traitement de troubles medies par l'acyle coa-diacylglycerol transferase 1 (dgat1). | |
| MA34599B1 (fr) | Compositions pharmaceutiques contenant un inhibiteur dgat1 | |
| MA31366B1 (fr) | Derives d'azetidine et leur utilisation comme antagonistes de prostaglandine e2 | |
| MA42988B1 (fr) | Dérivés d'éther spirocycliques de pyrazolo [1,5-a] pyrimidine-3-carboxamide |