CR20170371A - Compuestos de benzoxaboral 4-sustituidos y uso de los mismos - Google Patents
Compuestos de benzoxaboral 4-sustituidos y uso de los mismosInfo
- Publication number
- CR20170371A CR20170371A CR20170371A CR20170371A CR20170371A CR 20170371 A CR20170371 A CR 20170371A CR 20170371 A CR20170371 A CR 20170371A CR 20170371 A CR20170371 A CR 20170371A CR 20170371 A CR20170371 A CR 20170371A
- Authority
- CR
- Costa Rica
- Prior art keywords
- compounds
- substituted
- benzoxaboral
- same
- ch2ch2ch3
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010062207 Mycobacterial infection Diseases 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000002179 anti-microbacterial effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000027531 mycobacterial infectious disease Diseases 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Se proporcionan benzoxaboroles sustituidos cuya est ructura comprende la fórmula I I I : en donde R3 se selecciona a part ir de ¿CH3 , ¿CH2CH3 , ¿CH2 =CH2 ,¿CH2CH2CH3, ¿CH(CH3 )2, ¿CH2CH2 =CH2 y ciclopropilo, R1 y R2 se seleccionan cada uno independientemente a partir de H, -CH3 ,-CH2CH3 , ¿CH2CH2CH3 y ¿CH(CH3 ) 2 ; composiciones que contienen estos compuestos, su uso en terapia, incluyendo su uso como agentes anti -micobacterianos, por ejemplo, en el tratamiento de una infección micobacteriana en un mamífero, y los métodos para la preparación de estos compuestos.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15382054 | 2015-02-12 | ||
| EP15382055 | 2015-02-12 | ||
| EP15382056 | 2015-02-12 | ||
| PCT/IB2016/050775 WO2016128948A1 (en) | 2015-02-12 | 2016-02-12 | 4 -substituted benzoxaborole compounds and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20170371A true CR20170371A (es) | 2018-01-22 |
Family
ID=55409879
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20170371A CR20170371A (es) | 2015-02-12 | 2016-02-12 | Compuestos de benzoxaboral 4-sustituidos y uso de los mismos |
| CR20170372A CR20170372A (es) | 2015-02-12 | 2016-02-12 | Compuestos de benzoxaborol y usos de los mismos |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20170372A CR20170372A (es) | 2015-02-12 | 2016-02-12 | Compuestos de benzoxaborol y usos de los mismos |
Country Status (35)
| Country | Link |
|---|---|
| US (3) | US20180037595A1 (es) |
| EP (2) | EP3256479B1 (es) |
| JP (2) | JP2018506540A (es) |
| KR (2) | KR20170117156A (es) |
| CN (2) | CN107548398A (es) |
| AU (3) | AU2016217508A1 (es) |
| BR (2) | BR112017017213A2 (es) |
| CA (2) | CA2976030C (es) |
| CL (2) | CL2017002059A1 (es) |
| CO (2) | CO2017008809A2 (es) |
| CR (2) | CR20170371A (es) |
| CY (1) | CY1123687T1 (es) |
| DK (1) | DK3256479T3 (es) |
| DO (2) | DOP2017000188A (es) |
| EA (2) | EA036516B1 (es) |
| ES (1) | ES2821951T3 (es) |
| HR (1) | HRP20201597T1 (es) |
| HU (1) | HUE051113T2 (es) |
| IL (2) | IL253864B (es) |
| LT (1) | LT3256479T (es) |
| MA (2) | MA41494B1 (es) |
| MX (2) | MX2017010413A (es) |
| MY (1) | MY194004A (es) |
| NZ (1) | NZ734379A (es) |
| PE (2) | PE20171348A1 (es) |
| PH (2) | PH12017501427A1 (es) |
| PL (1) | PL3256479T3 (es) |
| PT (1) | PT3256479T (es) |
| RS (1) | RS60885B1 (es) |
| SG (2) | SG11201706510YA (es) |
| SI (1) | SI3256479T1 (es) |
| TW (2) | TWI730953B (es) |
| UA (1) | UA120527C2 (es) |
| WO (2) | WO2016128949A1 (es) |
| ZA (1) | ZA201705456B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP2016009046A0 (en) * | 2013-08-09 | 2016-02-29 | Anacor Pharmaceuticals Inc | Tricyclic benzoxaborole compounds and uses thereof |
| CA3060396A1 (en) * | 2017-05-08 | 2018-11-15 | Glaxosmithkline Intellectual Property Development Limited | Sanfetrinem or a salt or ester thereof for use in treating mycobacterial infection |
| BR112020010927A2 (pt) | 2017-11-30 | 2020-12-01 | Boragen, Inc. | compostos de benzoxaborol e formulações dos mesmos |
| JP2021534247A (ja) | 2018-08-18 | 2021-12-09 | ボラゲン，インコーポレーテッド | 置換ベンゾキサボロールの固体形態およびその組成物 |
| CN110441344B (zh) * | 2019-06-25 | 2020-09-29 | 北京大学 | 一种基于固体核磁共振技术检测rna结构的方法 |
| WO2023246841A1 (en) * | 2022-06-23 | 2023-12-28 | Shanghai Micurx Pharmaceutical Co., Ltd. | Methods and uses of boron compounds in the treatment of nontuberculous mycobacterium infections and pharmaceutical compositions for treatment of same |
| AU2023287063A1 (en) * | 2022-06-23 | 2024-05-30 | Shanghai Micurx Pharmaceutical Co., Ltd. | Prodrugs of boron compounds and their use in treating bacterial infections |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9411587D0 (en) * | 1994-06-09 | 1994-08-03 | Zeneca Ltd | Compound, composition and use |
| EP0947498B1 (en) | 1996-12-02 | 2004-09-15 | Chisso Corporation | Optically active nitro alcohol derivatives, optically active amino alcohol derivatives, and process for preparing the same |
| DE60313357T2 (de) | 2002-12-02 | 2008-01-03 | Solvias Ag | Verfahren zur katalytischen hydrierung von kohlenstoff-heteroatom-doppelbindungen |
| KR101337045B1 (ko) | 2005-02-16 | 2013-12-05 | 아나코르 파마슈티칼스 인코포레이티드 | 보론함유 소분자 |
| WO2006096131A1 (en) | 2005-03-08 | 2006-09-14 | Agency For Science, Technology And Research | Chiral bisoxazoline catalysts |
| EP1976536A4 (en) | 2005-12-30 | 2011-03-02 | Anacor Pharmaceuticals Inc | SMALL MOLECULES CONTAINING BORON |
| TWM325238U (en) * | 2006-12-29 | 2008-01-11 | Universal Scient Ind Co Ltd | Voltage regulator and voltage regulating system |
| KR100848491B1 (ko) | 2007-01-16 | 2008-07-28 | 영진약품공업주식회사 | 베타아미노기를 갖는 2-싸이아졸리딘 유도체, 이의약학적으로 허용 가능한 염 및 이의 제조 방법 |
| JO3396B1 (ar) | 2007-06-20 | 2019-10-20 | Anacor Pharmaceuticals Inc | جزيئات صغيرة تحتوي على البورون |
| CN102256494A (zh) | 2008-12-17 | 2011-11-23 | 阿纳科制药公司 | (s)-3-氨甲基-7-(3-羟基-丙氧基)-3h-苯并[c][1,2]氧杂硼杂环戊-1-醇的多晶型物 |
| US20110124597A1 (en) * | 2009-09-25 | 2011-05-26 | Anacor Pharmaceuticals, Inc. | Boron containing small molecules |
| CA2794684C (en) | 2010-04-07 | 2018-04-24 | Glaxosmithkline Llc | Process for preparing benzoxaboroles |
| PL3251678T3 (pl) | 2010-09-07 | 2022-01-10 | Anacor Pharmaceuticals, Inc. | Pochodne benzoksaborolu do leczenia zakażeń bakteryjnych |
| CA2858799A1 (en) | 2011-12-22 | 2013-06-27 | Micurx Pharmaceuticals, Inc. | Tricyclic boron compounds for antimicrobial therapy |
| CN102739587B (zh) | 2012-06-16 | 2014-05-21 | 天地融科技股份有限公司 | 音频数据传输方法 |
| KR101636431B1 (ko) | 2013-07-30 | 2016-07-05 | 동아에스티 주식회사 | 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도 |
| AP2016009046A0 (en) * | 2013-08-09 | 2016-02-29 | Anacor Pharmaceuticals Inc | Tricyclic benzoxaborole compounds and uses thereof |
-
2016
- 2016-02-11 MA MA41494A patent/MA41494B1/fr unknown
- 2016-02-11 MA MA041495A patent/MA41495A/fr unknown
- 2016-02-12 MX MX2017010413A patent/MX2017010413A/es unknown
- 2016-02-12 ES ES16706002T patent/ES2821951T3/es active Active
- 2016-02-12 BR BR112017017213-5A patent/BR112017017213A2/pt not_active Application Discontinuation
- 2016-02-12 CR CR20170371A patent/CR20170371A/es unknown
- 2016-02-12 JP JP2017542053A patent/JP2018506540A/ja active Pending
- 2016-02-12 AU AU2016217508A patent/AU2016217508A1/en not_active Abandoned
- 2016-02-12 CN CN201680021488.3A patent/CN107548398A/zh active Pending
- 2016-02-12 PT PT167060029T patent/PT3256479T/pt unknown
- 2016-02-12 PL PL16706002T patent/PL3256479T3/pl unknown
- 2016-02-12 SG SG11201706510YA patent/SG11201706510YA/en unknown
- 2016-02-12 UA UAA201708405A patent/UA120527C2/uk unknown
- 2016-02-12 MX MX2017010414A patent/MX2017010414A/es unknown
- 2016-02-12 MY MYPI2017702943A patent/MY194004A/en unknown
- 2016-02-12 EP EP16706002.9A patent/EP3256479B1/en active Active
- 2016-02-12 SI SI201630941T patent/SI3256479T1/sl unknown
- 2016-02-12 EA EA201791671A patent/EA036516B1/ru unknown
- 2016-02-12 WO PCT/IB2016/050776 patent/WO2016128949A1/en active Application Filing
- 2016-02-12 WO PCT/IB2016/050775 patent/WO2016128948A1/en active Application Filing
- 2016-02-12 AU AU2016217507A patent/AU2016217507B2/en active Active
- 2016-02-12 LT LTEP16706002.9T patent/LT3256479T/lt unknown
- 2016-02-12 KR KR1020177025535A patent/KR20170117156A/ko unknown
- 2016-02-12 CA CA2976030A patent/CA2976030C/en active Active
- 2016-02-12 US US15/550,658 patent/US20180037595A1/en not_active Abandoned
- 2016-02-12 PE PE2017001401A patent/PE20171348A1/es not_active Application Discontinuation
- 2016-02-12 NZ NZ734379A patent/NZ734379A/en unknown
- 2016-02-12 CA CA2976308A patent/CA2976308A1/en not_active Abandoned
- 2016-02-12 EA EA201791667A patent/EA201791667A1/ru unknown
- 2016-02-12 SG SG11201706511TA patent/SG11201706511TA/en unknown
- 2016-02-12 BR BR112017017211-9A patent/BR112017017211B1/pt active IP Right Grant
- 2016-02-12 CR CR20170372A patent/CR20170372A/es unknown
- 2016-02-12 RS RS20201204A patent/RS60885B1/sr unknown
- 2016-02-12 JP JP2017541999A patent/JP6771472B2/ja active Active
- 2016-02-12 US US15/550,693 patent/US10774096B2/en active Active
- 2016-02-12 HU HUE16706002A patent/HUE051113T2/hu unknown
- 2016-02-12 CN CN201680021538.8A patent/CN107531730B/zh active Active
- 2016-02-12 PE PE2017001400A patent/PE20171432A1/es not_active Application Discontinuation
- 2016-02-12 KR KR1020177025539A patent/KR20170117158A/ko not_active Application Discontinuation
- 2016-02-12 DK DK16706002.9T patent/DK3256479T3/da active
- 2016-02-12 EP EP16706003.7A patent/EP3256480A1/en not_active Withdrawn
- 2016-02-15 TW TW105104376A patent/TWI730953B/zh not_active IP Right Cessation
- 2016-02-15 TW TW105104422A patent/TW201702250A/zh unknown
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2017
- 2017-08-07 IL IL253864A patent/IL253864B/en unknown
- 2017-08-07 IL IL253865A patent/IL253865A0/en unknown
- 2017-08-09 PH PH12017501427A patent/PH12017501427A1/en unknown
- 2017-08-09 PH PH12017501428A patent/PH12017501428A1/en unknown
- 2017-08-10 DO DO2017000188A patent/DOP2017000188A/es unknown
- 2017-08-10 DO DO2017000189A patent/DOP2017000189A/es unknown
- 2017-08-11 CL CL2017002059A patent/CL2017002059A1/es unknown
- 2017-08-11 ZA ZA201705456A patent/ZA201705456B/en unknown
- 2017-08-11 CL CL2017002060A patent/CL2017002060A1/es unknown
- 2017-08-29 CO CONC2017/0008809A patent/CO2017008809A2/es unknown
- 2017-08-29 CO CONC2017/0008816A patent/CO2017008816A2/es unknown
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2020
- 2020-09-11 US US17/018,301 patent/US11214582B2/en active Active
- 2020-10-07 HR HRP20201597TT patent/HRP20201597T1/hr unknown
- 2020-10-14 AU AU2020256369A patent/AU2020256369A1/en not_active Abandoned
- 2020-10-15 CY CY20201100978T patent/CY1123687T1/el unknown
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