EA201791671A1 - 4-замещенные соединения бензоксаборола и их применение - Google Patents

4-замещенные соединения бензоксаборола и их применение

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Publication number
EA201791671A1
EA201791671A1 EA201791671A EA201791671A EA201791671A1 EA 201791671 A1 EA201791671 A1 EA 201791671A1 EA 201791671 A EA201791671 A EA 201791671A EA 201791671 A EA201791671 A EA 201791671A EA 201791671 A1 EA201791671 A1 EA 201791671A1
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EA
Eurasian Patent Office
Prior art keywords
compounds
substituted
benzoxoborol
application
mycobacterial
Prior art date
Application number
EA201791671A
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English (en)
Other versions
EA036516B1 (ru
Inventor
Карлос Алемпарте-Гальардо
М.Р.К. Элли (Дикон)
Дэвид Баррос-Агирре
Илариа Джордано
Винсент Эрнандес
Сяньфэн Ли
Джейкоб Дж. Плэттнер
Original Assignee
Глаксосмитклайн Интеллекчуал Проперти (№2) Лимитед
Анакор Фармасьютикалс, Инк.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55409879&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201791671(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Глаксосмитклайн Интеллекчуал Проперти (№2) Лимитед, Анакор Фармасьютикалс, Инк. filed Critical Глаксосмитклайн Интеллекчуал Проперти (№2) Лимитед
Publication of EA201791671A1 publication Critical patent/EA201791671A1/ru
Publication of EA036516B1 publication Critical patent/EA036516B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

Предложены замещенные бензоксаборолы, структура которых включает формулу IIIгде Rвыбран из -CH, -CHCH, -CH=CH, -CHCHCH, -CH(CH), -CHCH=CHи циклопропила, каждый из Rи Rнезависимо выбран из H, -CH, -CHCH, -CHCHCHи -CH(CH); композиции, содержащие такие соединения, их применение в терапии, включая их применение в качестве антимикобактериальных агентов, например в лечении микобактериальной инфекции у млекопитающего, и способы получения таких соединений.
EA201791671A 2015-02-12 2016-02-12 4-замещенные соединения бензоксаборола и их применение EA036516B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP15382056 2015-02-12
EP15382054 2015-02-12
EP15382055 2015-02-12
PCT/IB2016/050775 WO2016128948A1 (en) 2015-02-12 2016-02-12 4 -substituted benzoxaborole compounds and uses thereof

Publications (2)

Publication Number Publication Date
EA201791671A1 true EA201791671A1 (ru) 2018-02-28
EA036516B1 EA036516B1 (ru) 2020-11-18

Family

ID=55409879

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EA201791667A EA201791667A1 (ru) 2015-02-12 2016-02-12 Соединения бензоксаборола и их применение
EA201791671A EA036516B1 (ru) 2015-02-12 2016-02-12 4-замещенные соединения бензоксаборола и их применение

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US (3) US20180037595A1 (ru)
EP (2) EP3256479B1 (ru)
JP (2) JP2018506540A (ru)
KR (2) KR20170117156A (ru)
CN (2) CN107548398A (ru)
AU (3) AU2016217508A1 (ru)
BR (2) BR112017017213A2 (ru)
CA (2) CA2976308A1 (ru)
CL (2) CL2017002059A1 (ru)
CO (2) CO2017008809A2 (ru)
CR (2) CR20170372A (ru)
CY (1) CY1123687T1 (ru)
DK (1) DK3256479T3 (ru)
DO (2) DOP2017000189A (ru)
EA (2) EA201791667A1 (ru)
ES (1) ES2821951T3 (ru)
HR (1) HRP20201597T1 (ru)
HU (1) HUE051113T2 (ru)
IL (2) IL253864B (ru)
LT (1) LT3256479T (ru)
MA (2) MA41495A (ru)
MX (2) MX2017010414A (ru)
MY (1) MY194004A (ru)
NZ (1) NZ734379A (ru)
PE (2) PE20171348A1 (ru)
PH (2) PH12017501428A1 (ru)
PL (1) PL3256479T3 (ru)
PT (1) PT3256479T (ru)
RS (1) RS60885B1 (ru)
SG (2) SG11201706511TA (ru)
SI (1) SI3256479T1 (ru)
TW (2) TW201702250A (ru)
UA (1) UA120527C2 (ru)
WO (2) WO2016128948A1 (ru)
ZA (1) ZA201705456B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105492388B (zh) * 2013-08-09 2018-12-21 葛兰素史克知识产权第二有限公司 三环苯并氧杂硼杂环戊烯化合物及其用途
BR112019023322B1 (pt) * 2017-05-08 2023-11-14 Glaxosmithkline Intellectual Property Development Limited Uso do sanfetrinem, sanfetrinem sódico ou sanfetrinem cilexetila para a produção de um medicamento para o tratamento de tuberculose e combinação de sanfetrinem
MX2020005464A (es) 2017-11-30 2020-12-03 Boragen Inc Compuestos de benzoxaborol y formulaciones de los mismos.
US11236115B2 (en) 2018-08-18 2022-02-01 5Metis, Inc. Solid forms of substituted benzoxaborole and compositions thereof
CN110441344B (zh) * 2019-06-25 2020-09-29 北京大学 一种基于固体核磁共振技术检测rna结构的方法
WO2023246841A1 (en) * 2022-06-23 2023-12-28 Shanghai Micurx Pharmaceutical Co., Ltd. Methods and uses of boron compounds in the treatment of nontuberculous mycobacterium infections and pharmaceutical compositions for treatment of same
WO2023246842A1 (en) * 2022-06-23 2023-12-28 Shanghai Micurx Pharmaceutical Co., Ltd. Prodrugs of boron compounds and their use in treating bacterial infections

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9411587D0 (en) * 1994-06-09 1994-08-03 Zeneca Ltd Compound, composition and use
EP0947498B1 (en) 1996-12-02 2004-09-15 Chisso Corporation Optically active nitro alcohol derivatives, optically active amino alcohol derivatives, and process for preparing the same
CN100384791C (zh) 2002-12-02 2008-04-30 索尔维亚斯股份公司 碳-杂原子双键的催化氢化
PT3424932T (pt) 2005-02-16 2021-05-19 Anacor Pharmaceuticals Inc Boronoftalidas para utilização terapêutica
JP5084717B2 (ja) 2005-03-08 2012-11-28 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ キラル・ビスオキサゾリン触媒
RU2008131324A (ru) 2005-12-30 2010-02-10 Анакор Фармасьютикалз, Инк. (Us) Борсодержащие малые молекулы
TWM325238U (en) * 2006-12-29 2008-01-11 Universal Scient Ind Co Ltd Voltage regulator and voltage regulating system
KR100848491B1 (ko) 2007-01-16 2008-07-28 영진약품공업주식회사 베타아미노기를 갖는 2-싸이아졸리딘 유도체, 이의약학적으로 허용 가능한 염 및 이의 제조 방법
JO3396B1 (ar) 2007-06-20 2019-10-20 Anacor Pharmaceuticals Inc جزيئات صغيرة تحتوي على البورون
CN102256494A (zh) 2008-12-17 2011-11-23 阿纳科制药公司 (s)-3-氨甲基-7-(3-羟基-丙氧基)-3h-苯并[c][1,2]氧杂硼杂环戊-1-醇的多晶型物
US20110124597A1 (en) * 2009-09-25 2011-05-26 Anacor Pharmaceuticals, Inc. Boron containing small molecules
JP5603998B2 (ja) 2010-04-07 2014-10-08 グラクソスミスクライン エルエルシー ベンゾオキサボロールの調製方法
EP2613788B1 (en) * 2010-09-07 2017-06-21 Anacor Pharmaceuticals, Inc. Benzoxaborole derivatives for treating bacterial infections
KR20140114380A (ko) 2011-12-22 2014-09-26 미큐알엑스 파마슈티칼스, 인크. 항미생물 요법용 트리시클릭 붕소 화합물
CN102739587B (zh) 2012-06-16 2014-05-21 天地融科技股份有限公司 音频数据传输方法
KR101636431B1 (ko) 2013-07-30 2016-07-05 동아에스티 주식회사 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도
CN105492388B (zh) 2013-08-09 2018-12-21 葛兰素史克知识产权第二有限公司 三环苯并氧杂硼杂环戊烯化合物及其用途

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Publication number Publication date
EA036516B1 (ru) 2020-11-18
WO2016128949A1 (en) 2016-08-18
PE20171432A1 (es) 2017-09-26
NZ734379A (en) 2023-06-30
ZA201705456B (en) 2019-10-30
PT3256479T (pt) 2020-10-22
SI3256479T1 (sl) 2020-11-30
PL3256479T3 (pl) 2021-06-14
CY1123687T1 (el) 2022-03-24
HUE051113T2 (hu) 2021-01-28
HRP20201597T1 (hr) 2020-12-25
BR112017017211B1 (pt) 2023-04-25
MX2017010414A (es) 2018-05-11
JP6771472B2 (ja) 2020-10-21
AU2020256369A1 (en) 2020-11-12
SG11201706511TA (en) 2017-09-28
ES2821951T3 (es) 2021-04-28
KR20170117156A (ko) 2017-10-20
MA41494A (fr) 2017-12-19
CO2017008809A2 (es) 2017-11-10
PH12017501427A1 (en) 2018-01-15
CO2017008816A2 (es) 2017-11-10
LT3256479T (lt) 2020-12-28
BR112017017211A2 (pt) 2018-04-03
US20180044353A1 (en) 2018-02-15
EP3256480A1 (en) 2017-12-20
CA2976308A1 (en) 2016-08-18
TW201643173A (zh) 2016-12-16
US10774096B2 (en) 2020-09-15
MA41494B1 (fr) 2020-10-28
PH12017501428A1 (en) 2018-01-15
AU2016217507A1 (en) 2017-09-28
EP3256479B1 (en) 2020-07-29
CL2017002059A1 (es) 2018-03-16
PE20171348A1 (es) 2017-09-13
CR20170372A (es) 2017-10-19
DOP2017000188A (es) 2017-09-15
JP2018506538A (ja) 2018-03-08
MY194004A (en) 2022-11-07
CN107531730A (zh) 2018-01-02
CA2976030A1 (en) 2016-08-18
KR20170117158A (ko) 2017-10-20
IL253864B (en) 2021-07-29
CR20170371A (es) 2018-01-22
WO2016128948A1 (en) 2016-08-18
MA41495A (fr) 2017-12-19
DK3256479T3 (da) 2020-11-02
SG11201706510YA (en) 2017-09-28
CL2017002060A1 (es) 2018-03-16
JP2018506540A (ja) 2018-03-08
IL253865A0 (en) 2017-10-31
US20180037595A1 (en) 2018-02-08
MX2017010413A (es) 2018-05-11
UA120527C2 (uk) 2019-12-26
RS60885B1 (sr) 2020-11-30
DOP2017000189A (es) 2018-02-15
EP3256479A1 (en) 2017-12-20
BR112017017213A2 (pt) 2018-04-03
TW201702250A (zh) 2017-01-16
AU2016217507B2 (en) 2019-03-14
CN107548398A (zh) 2018-01-05
CN107531730B (zh) 2020-08-07
EA201791667A1 (ru) 2018-02-28
TWI730953B (zh) 2021-06-21
CA2976030C (en) 2023-09-26
IL253864A0 (en) 2017-09-28
US11214582B2 (en) 2022-01-04
AU2016217508A1 (en) 2017-09-28
US20210053996A1 (en) 2021-02-25

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