CO2017008809A2 - Compuestos de benzoxaborol y uso de los mismos - Google Patents

Compuestos de benzoxaborol y uso de los mismos

Info

Publication number
CO2017008809A2
CO2017008809A2 CONC2017/0008809A CO2017008809A CO2017008809A2 CO 2017008809 A2 CO2017008809 A2 CO 2017008809A2 CO 2017008809 A CO2017008809 A CO 2017008809A CO 2017008809 A2 CO2017008809 A2 CO 2017008809A2
Authority
CO
Colombia
Prior art keywords
compounds
ch2ch2ch3
ch2ch3
benzoxaborol compounds
mycobacterial
Prior art date
Application number
CONC2017/0008809A
Other languages
English (en)
Inventor
M R K Alley (Dickon)
Jacob J Plattner
Xianfeng Li
David Barros-Aguirre
Ilaria Giordano
Vincent Hernandez
Carlos Alemparte-Gallardo
Original Assignee
Glaxosmithkline Ip No 2 Ltd
Anacor Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55409879&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO2017008809(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Ip No 2 Ltd, Anacor Pharmaceuticals Inc filed Critical Glaxosmithkline Ip No 2 Ltd
Publication of CO2017008809A2 publication Critical patent/CO2017008809A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

Se proporcionan benzoxaboroles sustituidos cuya estructura comprende la fórmula III, en donde R3 se selecciona a partir de –CH3, –CH2CH3, –CH2=CH2, –CH2CH2CH3, –CH(CH3)2, –CH2CH2=CH2 y ciclopropilo, R1 y R2 se seleccionan cada uno independientemente a partir de H, -CH3, -CH2CH3, –CH2CH2CH3 y –CH(CH3)2; composiciones que contienen estos compuestos, su uso en terapia, incluyendo su uso como agentes anti-micobacterianos, por ejemplo, en el tratamiento de una infección micobacteriana en un mamífero, y los métodos para la preparación de estos compuestos.
CONC2017/0008809A 2015-02-12 2017-08-29 Compuestos de benzoxaborol y uso de los mismos CO2017008809A2 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP15382055 2015-02-12
EP15382054 2015-02-12
EP15382056 2015-02-12
PCT/IB2016/050775 WO2016128948A1 (en) 2015-02-12 2016-02-12 4 -substituted benzoxaborole compounds and uses thereof

Publications (1)

Publication Number Publication Date
CO2017008809A2 true CO2017008809A2 (es) 2017-11-10

Family

ID=55409879

Family Applications (2)

Application Number Title Priority Date Filing Date
CONC2017/0008809A CO2017008809A2 (es) 2015-02-12 2017-08-29 Compuestos de benzoxaborol y uso de los mismos
CONC2017/0008816A CO2017008816A2 (es) 2015-02-12 2017-08-29 Compuestos de benzoxaborol y usos de los mismos

Family Applications After (1)

Application Number Title Priority Date Filing Date
CONC2017/0008816A CO2017008816A2 (es) 2015-02-12 2017-08-29 Compuestos de benzoxaborol y usos de los mismos

Country Status (35)

Country Link
US (3) US10774096B2 (es)
EP (2) EP3256480A1 (es)
JP (2) JP2018506540A (es)
KR (2) KR20170117156A (es)
CN (2) CN107531730B (es)
AU (3) AU2016217508A1 (es)
BR (2) BR112017017213A2 (es)
CA (2) CA2976308A1 (es)
CL (2) CL2017002060A1 (es)
CO (2) CO2017008809A2 (es)
CR (2) CR20170371A (es)
CY (1) CY1123687T1 (es)
DK (1) DK3256479T3 (es)
DO (2) DOP2017000189A (es)
EA (2) EA201791667A1 (es)
ES (1) ES2821951T3 (es)
HR (1) HRP20201597T1 (es)
HU (1) HUE051113T2 (es)
IL (2) IL253865A0 (es)
LT (1) LT3256479T (es)
MA (2) MA41494B1 (es)
MX (2) MX2017010414A (es)
MY (1) MY194004A (es)
NZ (1) NZ734379A (es)
PE (2) PE20171348A1 (es)
PH (2) PH12017501427A1 (es)
PL (1) PL3256479T3 (es)
PT (1) PT3256479T (es)
RS (1) RS60885B1 (es)
SG (2) SG11201706510YA (es)
SI (1) SI3256479T1 (es)
TW (2) TWI730953B (es)
UA (1) UA120527C2 (es)
WO (2) WO2016128948A1 (es)
ZA (1) ZA201705456B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ716350A (en) * 2013-08-09 2022-12-23 Glaxosmithkline Ip No 2 Ltd Tricyclic benzoxaborole compounds and uses thereof
JP7123074B2 (ja) * 2017-05-08 2022-08-22 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド マイコバクテリア感染の処置において使用するためのサンフェトリネム、その塩、またはそのエステル
EP3716766A4 (en) 2017-11-30 2021-12-22 Boragen, Inc. BENZOXABOROLE COMPOUNDS AND THEIR FORMULATIONS
BR112021003037A2 (pt) 2018-08-18 2021-05-11 Boragen, Inc. formas sólidas de benzoxaborol substituído e composições do mesmo
CN110441344B (zh) * 2019-06-25 2020-09-29 北京大学 一种基于固体核磁共振技术检测rna结构的方法
WO2023246841A1 (en) * 2022-06-23 2023-12-28 Shanghai Micurx Pharmaceutical Co., Ltd. Methods and uses of boron compounds in the treatment of nontuberculous mycobacterium infections and pharmaceutical compositions for treatment of same
WO2023246842A1 (en) * 2022-06-23 2023-12-28 Shanghai Micurx Pharmaceutical Co., Ltd. Prodrugs of boron compounds and their use in treating bacterial infections

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9411587D0 (en) * 1994-06-09 1994-08-03 Zeneca Ltd Compound, composition and use
DE69730737D1 (de) 1996-12-02 2004-10-21 Chisso Corp Optisch aktive nitroalkohol-derivate, optisch aktive aminoalkohol-derivate und verfahren zu ihrer herstellung
CN100384791C (zh) 2002-12-02 2008-04-30 索尔维亚斯股份公司 碳-杂原子双键的催化氢化
MX369262B (es) 2005-02-16 2019-11-04 Anacor Pharmaceuticals Inc Moleculas pequeñas que contienen boro.
EP1856113B1 (en) 2005-03-08 2016-01-06 Agency for Science, Technology and Research Chiral bisoxazoline catalysts
CN105949230A (zh) 2005-12-30 2016-09-21 安纳考尔医药公司 含硼的小分子
TWM325238U (en) * 2006-12-29 2008-01-11 Universal Scient Ind Co Ltd Voltage regulator and voltage regulating system
KR100848491B1 (ko) 2007-01-16 2008-07-28 영진약품공업주식회사 베타아미노기를 갖는 2-싸이아졸리딘 유도체, 이의약학적으로 허용 가능한 염 및 이의 제조 방법
JO3396B1 (ar) * 2007-06-20 2019-10-20 Anacor Pharmaceuticals Inc جزيئات صغيرة تحتوي على البورون
BRPI0922566A2 (pt) 2008-12-17 2017-03-28 Anacor Pharmaceuticals Inc polimorfo cristalino, composição farmacêutica, composto, e, métodos para preparar um composto, e para tratar uma doença.
US20110124597A1 (en) * 2009-09-25 2011-05-26 Anacor Pharmaceuticals, Inc. Boron containing small molecules
CN102821609B (zh) 2010-04-07 2015-03-25 葛兰素史密丝克莱恩有限责任公司 用于制备苯并氧杂硼杂环戊烯的方法
DK2613788T3 (en) 2010-09-07 2017-08-07 Anacor Pharmaceuticals Inc BENZOXABOROLD DERIVATIVES FOR TREATMENT OF BACTERIA INFECTIONS
WO2013093615A1 (en) 2011-12-22 2013-06-27 Micurx Pharmaceuticals, Inc. Tricyclic boron compounds for antimicrobial therapy
CN102739587B (zh) 2012-06-16 2014-05-21 天地融科技股份有限公司 音频数据传输方法
KR101636431B1 (ko) 2013-07-30 2016-07-05 동아에스티 주식회사 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도
NZ716350A (en) * 2013-08-09 2022-12-23 Glaxosmithkline Ip No 2 Ltd Tricyclic benzoxaborole compounds and uses thereof

Also Published As

Publication number Publication date
WO2016128948A1 (en) 2016-08-18
TW201643173A (zh) 2016-12-16
CA2976308A1 (en) 2016-08-18
EP3256479B1 (en) 2020-07-29
CY1123687T1 (el) 2022-03-24
HUE051113T2 (hu) 2021-01-28
TW201702250A (zh) 2017-01-16
UA120527C2 (uk) 2019-12-26
PE20171348A1 (es) 2017-09-13
EP3256479A1 (en) 2017-12-20
CN107531730B (zh) 2020-08-07
AU2016217508A1 (en) 2017-09-28
BR112017017211A2 (pt) 2018-04-03
US20180044353A1 (en) 2018-02-15
BR112017017211B1 (pt) 2023-04-25
KR20170117156A (ko) 2017-10-20
ES2821951T3 (es) 2021-04-28
MA41494A (fr) 2017-12-19
PL3256479T3 (pl) 2021-06-14
HRP20201597T1 (hr) 2020-12-25
CR20170372A (es) 2017-10-19
JP2018506538A (ja) 2018-03-08
CN107548398A (zh) 2018-01-05
EA201791671A1 (ru) 2018-02-28
CA2976030C (en) 2023-09-26
EA036516B1 (ru) 2020-11-18
KR20170117158A (ko) 2017-10-20
IL253864B (en) 2021-07-29
AU2016217507A1 (en) 2017-09-28
DOP2017000189A (es) 2018-02-15
TWI730953B (zh) 2021-06-21
IL253864A0 (en) 2017-09-28
CA2976030A1 (en) 2016-08-18
MA41495A (fr) 2017-12-19
IL253865A0 (en) 2017-10-31
EA201791667A1 (ru) 2018-02-28
MX2017010413A (es) 2018-05-11
MA41494B1 (fr) 2020-10-28
DK3256479T3 (da) 2020-11-02
MX2017010414A (es) 2018-05-11
WO2016128949A1 (en) 2016-08-18
MY194004A (en) 2022-11-07
JP6771472B2 (ja) 2020-10-21
PT3256479T (pt) 2020-10-22
SI3256479T1 (sl) 2020-11-30
JP2018506540A (ja) 2018-03-08
CO2017008816A2 (es) 2017-11-10
PH12017501428A1 (en) 2018-01-15
AU2020256369A1 (en) 2020-11-12
US20180037595A1 (en) 2018-02-08
NZ734379A (en) 2023-06-30
LT3256479T (lt) 2020-12-28
CN107531730A (zh) 2018-01-02
ZA201705456B (en) 2019-10-30
SG11201706510YA (en) 2017-09-28
US10774096B2 (en) 2020-09-15
PE20171432A1 (es) 2017-09-26
RS60885B1 (sr) 2020-11-30
PH12017501427A1 (en) 2018-01-15
US11214582B2 (en) 2022-01-04
CR20170371A (es) 2018-01-22
AU2016217507B2 (en) 2019-03-14
EP3256480A1 (en) 2017-12-20
CL2017002059A1 (es) 2018-03-16
SG11201706511TA (en) 2017-09-28
DOP2017000188A (es) 2017-09-15
US20210053996A1 (en) 2021-02-25
CL2017002060A1 (es) 2018-03-16
BR112017017213A2 (pt) 2018-04-03

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