EA201792025A1 - Трициклические гетероциклические соединения, применимые в качестве ингибиторов tnf - Google Patents
Трициклические гетероциклические соединения, применимые в качестве ингибиторов tnfInfo
- Publication number
- EA201792025A1 EA201792025A1 EA201792025A EA201792025A EA201792025A1 EA 201792025 A1 EA201792025 A1 EA 201792025A1 EA 201792025 A EA201792025 A EA 201792025A EA 201792025 A EA201792025 A EA 201792025A EA 201792025 A1 EA201792025 A1 EA 201792025A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- crr
- heterocyclic compounds
- tricyclic heterocyclic
- tnf inhibitors
- compounds applicable
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epidemiology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Раскрываются соединения формулы (I)или их соль, в которых X представляет собой N; W представляет собой -(CRR)-, -(CRR)-Y-(CRR)-, -Y-(CRR)-Y-, -CRR-Y-(CRR)-Y-, -Y-(CRR)-Y-CRR-; a Y, R, R, R, R, R, R, x и у определяются в настоящем документе. Также раскрываются способы применения таких соединений в качестве модуляторов TNFα, а также фармацевтические композиции, содержащие такие соединения. Данные соединения применимы при лечении воспалительных и аутоиммунных заболеваний.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562134779P | 2015-03-18 | 2015-03-18 | |
PCT/US2016/022738 WO2016149437A1 (en) | 2015-03-18 | 2016-03-17 | Tricyclic heterocyclic compounds useful as inhibitors of tnf |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201792025A1 true EA201792025A1 (ru) | 2018-01-31 |
EA032314B1 EA032314B1 (ru) | 2019-05-31 |
Family
ID=55640933
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201792025A EA032314B1 (ru) | 2015-03-18 | 2016-03-17 | Трициклические гетероциклические соединения, применимые в качестве ингибиторов tnf |
Country Status (14)
Country | Link |
---|---|
US (1) | US10308652B2 (ru) |
EP (1) | EP3271361B1 (ru) |
JP (1) | JP6793658B2 (ru) |
KR (1) | KR102630010B1 (ru) |
CN (1) | CN107635992B (ru) |
AU (1) | AU2016233289A1 (ru) |
BR (1) | BR112017019731A2 (ru) |
CA (1) | CA2982446A1 (ru) |
EA (1) | EA032314B1 (ru) |
ES (1) | ES2797685T3 (ru) |
IL (1) | IL254520A0 (ru) |
MX (1) | MX2017011433A (ru) |
SG (1) | SG11201707471RA (ru) |
WO (1) | WO2016149437A1 (ru) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA032315B1 (ru) | 2015-03-18 | 2019-05-31 | Бристол-Маерс Сквибб Компани | Замещенные трициклические гетероциклические соединения |
BR112017019605A2 (pt) | 2015-03-18 | 2018-05-08 | Bristol-Myers Squibb Company | compostos heterocíclicos úteis como inibidores de tnf |
TW201710257A (zh) | 2015-04-17 | 2017-03-16 | 艾伯維有限公司 | Tnf信號傳遞之三環調節劑 |
EP3294726A1 (en) | 2015-04-17 | 2018-03-21 | AbbVie Inc. | Indazolones as modulators of tnf signaling |
UY36628A (es) | 2015-04-17 | 2016-11-30 | Abbvie Inc | Indazolonas como moduladores de la señalización de tnf |
GB201510758D0 (en) | 2015-06-18 | 2015-08-05 | Ucb Biopharma Sprl | Novel TNFa structure for use in therapy |
EA201890421A1 (ru) | 2015-08-03 | 2018-07-31 | Бристол-Маерс Сквибб Компани | Циклические соединения, пригодные в качестве модуляторов tnf-альфа |
GB201621907D0 (en) | 2016-12-21 | 2017-02-01 | Ucb Biopharma Sprl And Sanofi | Antibody epitope |
CN110461842A (zh) | 2017-03-15 | 2019-11-15 | Ucb生物制药私人有限公司 | 作为tnf活性调节剂的稠合五环咪唑衍生物 |
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US4391806A (en) * | 1982-07-12 | 1983-07-05 | The Dow Chemical Company | Substituted tetrahydropyridazino-(1,6-A)benzimidazoles and use as bronchodilators |
AU741772B2 (en) | 1997-02-25 | 2001-12-06 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Substituted benzimidazoles as non-nucleoside inhibitors of reverse transcriptase |
WO2001030778A1 (en) * | 1999-10-27 | 2001-05-03 | Novartis Ag | Thiazole and imidazo [4,5-b] pyridine compounds and their pharmaceutical use |
CN1633434A (zh) | 2002-01-31 | 2005-06-29 | 第一制药株式会社 | 咪唑并[1,2-a]吡啶衍生物 |
WO2004050035A2 (en) | 2002-12-03 | 2004-06-17 | Isis Pharmaceuticals, Inc. | Benzimidazoles and analogs thereof as antivirals |
US20050124638A1 (en) | 2003-12-08 | 2005-06-09 | Swayze Eric E. | Benzimidazoles and analogs thereof as antivirals |
WO2009045174A1 (en) | 2007-10-05 | 2009-04-09 | S*Bio Pte Ltd | 2-morpholinylpurines as inhibitors of pi3k |
CN101717397B (zh) | 2008-10-09 | 2012-11-28 | 中国科学院上海药物研究所 | 一类取代吡啶并[2',1':2,3]咪唑并[4,5-c]异喹啉酮类化合物及其合成方法和用途,以及包含该类化合物的药物组合物 |
US8691187B2 (en) | 2009-03-23 | 2014-04-08 | Eli Lilly And Company | Imaging agents for detecting neurological disorders |
WO2012148550A1 (en) | 2011-02-25 | 2012-11-01 | Myrexis, Inc. | Prodrugs of therapeutic compounds |
EP2527344A1 (en) | 2011-05-25 | 2012-11-28 | Almirall, S.A. | Pyridin-2(1H)-one derivatives useful as medicaments for the treatment of myeloproliferative disorders, transplant rejection, immune-mediated and inflammatory diseases |
EP2858983B1 (en) | 2012-06-11 | 2018-04-18 | UCB Biopharma SPRL | Tnf-alpha modulating benzimidazoles |
US9309243B2 (en) * | 2012-07-13 | 2016-04-12 | Ucb Biopharma Sprl | Imidazopyridine derivatives as modulators of TNF activity |
GB201212513D0 (en) | 2012-07-13 | 2012-08-29 | Ucb Pharma Sa | Therapeutic agents |
BR112015009649A2 (pt) * | 2012-11-07 | 2017-07-04 | Hoffmann La Roche | composto de triazolo |
ES2529865B8 (es) * | 2013-07-25 | 2016-01-22 | Fundación Para La Investigación Biomédica Del Hospital Universitario La Paz (Fibhulp) | USO DE COMPUESTOS DERIVADOS DE SALES DE PIRIDAZINO[1',6':1,2]PIRIDO[3,4-b]INDOLINIO COMO AGENTES ANTIINFLAMATORIOS |
GB201321738D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
GB201321742D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
GB201321746D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
GB201321743D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
GB201321737D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
CN105814022B (zh) | 2013-12-09 | 2018-09-28 | Ucb生物制药私人有限公司 | 作为tnf活性调节剂的稠合的二环杂芳族衍生物 |
GB201321735D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
GB201321739D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
GB201321745D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
CA2930499C (en) | 2013-12-09 | 2021-11-23 | Ucb Biopharma Sprl | Imidazopyridine derivatives as modulators of tnf activity |
GB201321744D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
GB201321741D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
RS61884B1 (sr) | 2014-10-06 | 2021-06-30 | Signal Pharm Llc | Supstituisana aminopurinska jedinjenja, kompozicije koje ih sadrže i postupci za lečenje u kojima se koriste |
EA032315B1 (ru) | 2015-03-18 | 2019-05-31 | Бристол-Маерс Сквибб Компани | Замещенные трициклические гетероциклические соединения |
BR112017019605A2 (pt) | 2015-03-18 | 2018-05-08 | Bristol-Myers Squibb Company | compostos heterocíclicos úteis como inibidores de tnf |
TW201710257A (zh) * | 2015-04-17 | 2017-03-16 | 艾伯維有限公司 | Tnf信號傳遞之三環調節劑 |
CN107567449A (zh) * | 2015-05-04 | 2018-01-09 | 埃科特莱茵药品有限公司 | 三环哌啶化合物 |
-
2016
- 2016-03-17 AU AU2016233289A patent/AU2016233289A1/en not_active Abandoned
- 2016-03-17 ES ES16712646T patent/ES2797685T3/es active Active
- 2016-03-17 MX MX2017011433A patent/MX2017011433A/es unknown
- 2016-03-17 US US15/558,708 patent/US10308652B2/en active Active
- 2016-03-17 KR KR1020177029450A patent/KR102630010B1/ko active IP Right Grant
- 2016-03-17 BR BR112017019731-6A patent/BR112017019731A2/pt not_active Application Discontinuation
- 2016-03-17 EP EP16712646.5A patent/EP3271361B1/en active Active
- 2016-03-17 CA CA2982446A patent/CA2982446A1/en not_active Abandoned
- 2016-03-17 EA EA201792025A patent/EA032314B1/ru not_active IP Right Cessation
- 2016-03-17 JP JP2017549093A patent/JP6793658B2/ja active Active
- 2016-03-17 SG SG11201707471RA patent/SG11201707471RA/en unknown
- 2016-03-17 WO PCT/US2016/022738 patent/WO2016149437A1/en active Application Filing
- 2016-03-17 CN CN201680025154.3A patent/CN107635992B/zh active Active
-
2017
- 2017-09-15 IL IL254520A patent/IL254520A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20180111937A1 (en) | 2018-04-26 |
JP2018508554A (ja) | 2018-03-29 |
SG11201707471RA (en) | 2017-10-30 |
MX2017011433A (es) | 2017-11-10 |
ES2797685T3 (es) | 2020-12-03 |
JP6793658B2 (ja) | 2020-12-02 |
KR20170129811A (ko) | 2017-11-27 |
EA032314B1 (ru) | 2019-05-31 |
AU2016233289A1 (en) | 2017-11-09 |
EP3271361A1 (en) | 2018-01-24 |
CN107635992B (zh) | 2020-05-22 |
EP3271361B1 (en) | 2020-04-22 |
KR102630010B1 (ko) | 2024-01-25 |
IL254520A0 (en) | 2017-11-30 |
CN107635992A (zh) | 2018-01-26 |
US10308652B2 (en) | 2019-06-04 |
BR112017019731A2 (pt) | 2018-05-22 |
WO2016149437A1 (en) | 2016-09-22 |
CA2982446A1 (en) | 2016-09-22 |
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MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM RU |