MX2017011433A - Compuestos heterociclicos triciclicos utiles como inhibidores del factor de necrosis tumoral (tnf). - Google Patents

Compuestos heterociclicos triciclicos utiles como inhibidores del factor de necrosis tumoral (tnf).

Info

Publication number
MX2017011433A
MX2017011433A MX2017011433A MX2017011433A MX2017011433A MX 2017011433 A MX2017011433 A MX 2017011433A MX 2017011433 A MX2017011433 A MX 2017011433A MX 2017011433 A MX2017011433 A MX 2017011433A MX 2017011433 A MX2017011433 A MX 2017011433A
Authority
MX
Mexico
Prior art keywords
cr3r3
tnf
inhibitors
heterocyclic compounds
compounds useful
Prior art date
Application number
MX2017011433A
Other languages
English (en)
Inventor
G Murali Dhar T
Lin Shuqun
T Wrobleski Stephen
Xiao Hai-Yun
Lu Zhonghui
Duan Jingwu
J Tebben Andrew
d brown Gregory
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2017011433A publication Critical patent/MX2017011433A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se describen los compuestos de la Fórmula (I) o una sal de los mismos, en donde X es N; W es -(CR3R3)2-5-; -(CR3R3)x-Y-(CR3R3)y-, -Y-(CR3R3)2-3-Y-, -CR3R3-Y- (CR3R3)2-Y, -Y-(CR3R3)2-Y-CR3R3-; e Y, R1, R2, R3, R5, R6, R8, x e y son definidos en la presente. También se describen los métodos de uso de tales compuestos como moduladores de TNFa, y las composiciones farmacéuticas que comprenden tales compuestos. Estos compuestos son útiles en el tratamiento de trastornos inflamatorios y autoinmunitarios.
MX2017011433A 2015-03-18 2016-03-17 Compuestos heterociclicos triciclicos utiles como inhibidores del factor de necrosis tumoral (tnf). MX2017011433A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562134779P 2015-03-18 2015-03-18
PCT/US2016/022738 WO2016149437A1 (en) 2015-03-18 2016-03-17 Tricyclic heterocyclic compounds useful as inhibitors of tnf

Publications (1)

Publication Number Publication Date
MX2017011433A true MX2017011433A (es) 2017-11-10

Family

ID=55640933

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017011433A MX2017011433A (es) 2015-03-18 2016-03-17 Compuestos heterociclicos triciclicos utiles como inhibidores del factor de necrosis tumoral (tnf).

Country Status (14)

Country Link
US (1) US10308652B2 (es)
EP (1) EP3271361B1 (es)
JP (1) JP6793658B2 (es)
KR (1) KR102630010B1 (es)
CN (1) CN107635992B (es)
AU (1) AU2016233289A1 (es)
BR (1) BR112017019731A2 (es)
CA (1) CA2982446A1 (es)
EA (1) EA032314B1 (es)
ES (1) ES2797685T3 (es)
IL (1) IL254520A0 (es)
MX (1) MX2017011433A (es)
SG (1) SG11201707471RA (es)
WO (1) WO2016149437A1 (es)

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* Cited by examiner, † Cited by third party
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EA201792054A1 (ru) 2015-03-18 2018-01-31 Бристол-Майерс Сквибб Компани Гетероциклические соединения, применимые в качестве ингибиторов tnf
AU2016233288A1 (en) 2015-03-18 2017-11-09 Bristol-Myers Squibb Company Substituted tricyclic heterocyclic compounds
WO2016168633A1 (en) 2015-04-17 2016-10-20 Abbvie Inc. Indazolones as modulators of tnf signaling
UY36630A (es) 2015-04-17 2016-11-30 Abbvie Inc Moduladores tricíclicos de la señalización por tnf
TW201702247A (zh) 2015-04-17 2017-01-16 艾伯維有限公司 作為ｔｎｆ信號傳遞調節劑之吲唑酮
GB201510758D0 (en) 2015-06-18 2015-08-05 Ucb Biopharma Sprl Novel TNFa structure for use in therapy
KR20180031773A (ko) 2015-08-03 2018-03-28 브리스톨-마이어스 스큅 컴퍼니 Tnf 알파의 조정제로서 유용한 시클릭 화합물
GB201621907D0 (en) 2016-12-21 2017-02-01 Ucb Biopharma Sprl And Sanofi Antibody epitope
WO2018167176A1 (en) 2017-03-15 2018-09-20 Ucb Biopharma Sprl Fused pentacyclic imidazole derivatives as modulators of tnf activity

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EA201792054A1 (ru) 2015-03-18 2018-01-31 Бристол-Майерс Сквибб Компани Гетероциклические соединения, применимые в качестве ингибиторов tnf
AU2016233288A1 (en) 2015-03-18 2017-11-09 Bristol-Myers Squibb Company Substituted tricyclic heterocyclic compounds
UY36630A (es) * 2015-04-17 2016-11-30 Abbvie Inc Moduladores tricíclicos de la señalización por tnf
US20180155344A1 (en) * 2015-05-04 2018-06-07 Actelion Pharmaceuticals Ltd Tricyclic piperidine compounds

Also Published As

Publication number Publication date
CN107635992A (zh) 2018-01-26
WO2016149437A1 (en) 2016-09-22
JP6793658B2 (ja) 2020-12-02
KR20170129811A (ko) 2017-11-27
US10308652B2 (en) 2019-06-04
SG11201707471RA (en) 2017-10-30
BR112017019731A2 (pt) 2018-05-22
EA201792025A1 (ru) 2018-01-31
EP3271361B1 (en) 2020-04-22
KR102630010B1 (ko) 2024-01-25
CA2982446A1 (en) 2016-09-22
AU2016233289A1 (en) 2017-11-09
CN107635992B (zh) 2020-05-22
IL254520A0 (en) 2017-11-30
EP3271361A1 (en) 2018-01-24
JP2018508554A (ja) 2018-03-29
US20180111937A1 (en) 2018-04-26
ES2797685T3 (es) 2020-12-03
EA032314B1 (ru) 2019-05-31

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