EA201990048A1 - [1,2,4]ТРИАЗОЛО[1,5-a]ПИРИДИНИЛ-ЗАМЕЩЕННЫЕ ИНДОЛЬНЫЕ СОЕДИНЕНИЯ - Google Patents

[1,2,4]ТРИАЗОЛО[1,5-a]ПИРИДИНИЛ-ЗАМЕЩЕННЫЕ ИНДОЛЬНЫЕ СОЕДИНЕНИЯ

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Publication number
EA201990048A1
EA201990048A1 EA201990048A EA201990048A EA201990048A1 EA 201990048 A1 EA201990048 A1 EA 201990048A1 EA 201990048 A EA201990048 A EA 201990048A EA 201990048 A EA201990048 A EA 201990048A EA 201990048 A1 EA201990048 A1 EA 201990048A1
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EA
Eurasian Patent Office
Prior art keywords
compounds
triazolo
pyridinyl
substituted indol
indol compounds
Prior art date
Application number
EA201990048A
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English (en)
Other versions
EA037530B1 (ru
Inventor
Аларик Дж. Дикман
Дхармпал С. Додд
Тасир Шамсул Хак
Луис Дж. Ломбардо
Джон Е. Мэйкор
Кристофер П. Муссари
Лэксмен Пэсанури
Срикантха Ратна Кумар
Тревор С. Шервуд
Шошана Л. Поузе
Рамеш Кумар Систла
Субрамайя Хегде
Анупама Рамачандра
Original Assignee
Бристол-Майерс Сквибб Компани
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Publication of EA201990048A1 publication Critical patent/EA201990048A1/ru
Publication of EA037530B1 publication Critical patent/EA037530B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Раскрыты соединения формулы (I)или их соль, где R, R, R, R, R, m, n и p определены в настоящем описании. Также раскрыты способы применения таких соединений в качестве ингибиторов передачи сигналов через Toll-подобные рецепторы 7, 8 или 9 и фармацевтические композиции, содержащие такие соединения. Эти соединения применимы при лечении воспалительных и аутоиммунных заболеваний.
EA201990048A 2016-06-29 2017-06-28 [1,2,4]ТРИАЗОЛО[1,5-a]ПИРИДИНИЛЗАМЕЩЕННЫЕ ИНДОЛЬНЫЕ СОЕДИНЕНИЯ EA037530B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN201611022328 2016-06-29
US15/635,055 US10071079B2 (en) 2016-06-29 2017-06-27 [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds
PCT/US2017/039633 WO2018005586A1 (en) 2016-06-29 2017-06-28 [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds

Publications (2)

Publication Number Publication Date
EA201990048A1 true EA201990048A1 (ru) 2019-05-31
EA037530B1 EA037530B1 (ru) 2021-04-08

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EA201990048A EA037530B1 (ru) 2016-06-29 2017-06-28 [1,2,4]ТРИАЗОЛО[1,5-a]ПИРИДИНИЛЗАМЕЩЕННЫЕ ИНДОЛЬНЫЕ СОЕДИНЕНИЯ

Country Status (31)

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US (8) US10071079B2 (ru)
EP (1) EP3478682B1 (ru)
JP (1) JP6995067B6 (ru)
KR (1) KR102473482B1 (ru)
CN (1) CN109641895B (ru)
AR (1) AR108905A1 (ru)
AU (1) AU2017287902B2 (ru)
BR (1) BR112018077119A2 (ru)
CA (1) CA3029620A1 (ru)
CL (1) CL2018003821A1 (ru)
CO (1) CO2019000686A2 (ru)
CY (1) CY1124514T1 (ru)
DK (1) DK3478682T3 (ru)
EA (1) EA037530B1 (ru)
ES (1) ES2886964T3 (ru)
HR (1) HRP20211261T8 (ru)
HU (1) HUE056091T2 (ru)
IL (1) IL263961B (ru)
LT (1) LT3478682T (ru)
MX (1) MX2018015422A (ru)
MY (1) MY196474A (ru)
PE (1) PE20190324A1 (ru)
PL (1) PL3478682T3 (ru)
PT (1) PT3478682T (ru)
RS (1) RS62292B1 (ru)
SG (1) SG11201811590RA (ru)
SI (1) SI3478682T1 (ru)
TW (1) TWI636053B (ru)
UY (1) UY37310A (ru)
WO (1) WO2018005586A1 (ru)
ZA (1) ZA201900571B (ru)

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