CY1124514T1 - Ενωσεις [1,2,4]τριαζολο[1,5-α]πυριδινυλ-υποκατεστημενης ινδολης - Google Patents

Ενωσεις [1,2,4]τριαζολο[1,5-α]πυριδινυλ-υποκατεστημενης ινδολης

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Publication number
CY1124514T1
CY1124514T1 CY20211100814T CY211100814T CY1124514T1 CY 1124514 T1 CY1124514 T1 CY 1124514T1 CY 20211100814 T CY20211100814 T CY 20211100814T CY 211100814 T CY211100814 T CY 211100814T CY 1124514 T1 CY1124514 T1 CY 1124514T1
Authority
CY
Cyprus
Prior art keywords
triazolo
pyridinyl
compounds
substituted indole
indole compounds
Prior art date
Application number
CY20211100814T
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English (en)
Inventor
Alaric J. Dyckman
Dharmpal S. Dodd
Tasir Shamsul Haque
Louis J. Lombardo
John E. Macor
Christopher P. Mussari
Laxman PASUNOORI
Sreekantha RATNA KUMAR
Trevor C. Sherwood
Shoshana L. POSY
Ramesh Kumar SISTLA
Subramaya HEGDE
Anupama RAMACHANDRA
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of CY1124514T1 publication Critical patent/CY1124514T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Αποκαλύπτονται ενώσεις του Χημικού Τύπου (Ι) ή ένα άλας εξ αυτών, όπου τα R1, R2, R3, R4, R5, m, n, και p καθορίζονται εις το παρόν. Επίσης αποκαλύπτονται μέθοδοι χρήσης τέτοιων ενώσεων ως αναστολέων της σηματοδότησης μέσα από υποδοχέα τύπου Toll 7, ή 8, ή 9, και φαρμακευτικές συνθέσεις που περιλαμβάνουν τέτοιες ενώσεις. Αυτές οι ενώσεις είναι χρήσιμες σε αγωγή φλεγμονωδών και αυτοάνοσων παθήσεων.
CY20211100814T 2016-06-29 2021-09-15 Ενωσεις [1,2,4]τριαζολο[1,5-α]πυριδινυλ-υποκατεστημενης ινδολης CY1124514T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN201611022328 2016-06-29
US15/635,055 US10071079B2 (en) 2016-06-29 2017-06-27 [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds
PCT/US2017/039633 WO2018005586A1 (en) 2016-06-29 2017-06-28 [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds

Publications (1)

Publication Number Publication Date
CY1124514T1 true CY1124514T1 (el) 2022-07-22

Family

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Family Applications (1)

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CY20211100814T CY1124514T1 (el) 2016-06-29 2021-09-15 Ενωσεις [1,2,4]τριαζολο[1,5-α]πυριδινυλ-υποκατεστημενης ινδολης

Country Status (32)

Country Link
US (8) US10071079B2 (el)
EP (1) EP3478682B1 (el)
JP (1) JP6995067B6 (el)
KR (1) KR102473482B1 (el)
CN (1) CN109641895B (el)
AR (1) AR108905A1 (el)
AU (1) AU2017287902B2 (el)
BR (1) BR112018077119A2 (el)
CA (1) CA3029620A1 (el)
CL (1) CL2018003821A1 (el)
CO (1) CO2019000686A2 (el)
CY (1) CY1124514T1 (el)
DK (1) DK3478682T3 (el)
EA (1) EA037530B1 (el)
ES (1) ES2886964T3 (el)
HR (1) HRP20211261T8 (el)
HU (1) HUE056091T2 (el)
IL (1) IL263961B (el)
LT (1) LT3478682T (el)
MX (1) MX2018015422A (el)
MY (1) MY196474A (el)
NZ (1) NZ750180A (el)
PE (1) PE20190324A1 (el)
PL (1) PL3478682T3 (el)
PT (1) PT3478682T (el)
RS (1) RS62292B1 (el)
SG (1) SG11201811590RA (el)
SI (1) SI3478682T1 (el)
TW (1) TWI636053B (el)
UY (1) UY37310A (el)
WO (1) WO2018005586A1 (el)
ZA (1) ZA201900571B (el)

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