CY1121550T1 - Ενωσεις πυριδινης πλαδιενολιδης και μεθοδοι χρησης - Google Patents
Ενωσεις πυριδινης πλαδιενολιδης και μεθοδοι χρησηςInfo
- Publication number
- CY1121550T1 CY1121550T1 CY20191100228T CY191100228T CY1121550T1 CY 1121550 T1 CY1121550 T1 CY 1121550T1 CY 20191100228 T CY20191100228 T CY 20191100228T CY 191100228 T CY191100228 T CY 191100228T CY 1121550 T1 CY1121550 T1 CY 1121550T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compounds
- methods
- pyridine
- pladienolides
- useful
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003222 pyridines Chemical class 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει νέες ενώσεις πυριδίνης πλαδιενολίδης, φαρμακευτικές συνθέσεις που περιέχουν τέτοιες ενώσεις και μεθόδους για χρήση των ενώσεων ως θεραπευτικοί παράγοντες. Αυτές οι ενώσεις μπορεί να είναι χρήσιμες στη θεραπεία του καρκίνου, ιδιαίτερα των καρκίνων στους οποίους είναι γνωστό ότι οι παράγοντες που στοχεύουν το σωματίδιο συρραφής και τις μεταλλάξεις σε αυτό είναι χρήσιμοι.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461993423P | 2014-05-15 | 2014-05-15 | |
| PCT/US2015/030464 WO2015175594A1 (en) | 2014-05-15 | 2015-05-13 | Pladienolide pyridine compounds and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1121550T1 true CY1121550T1 (el) | 2020-05-29 |
Family
ID=53284528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20191100228T CY1121550T1 (el) | 2014-05-15 | 2019-02-22 | Ενωσεις πυριδινης πλαδιενολιδης και μεθοδοι χρησης |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US9481669B2 (el) |
| EP (2) | EP3514154B1 (el) |
| JP (1) | JP6067943B1 (el) |
| KR (2) | KR101710318B1 (el) |
| CN (1) | CN107074827B (el) |
| AR (1) | AR100431A1 (el) |
| AU (1) | AU2015259237B2 (el) |
| BR (1) | BR112016026638B1 (el) |
| CA (1) | CA2947754C (el) |
| CL (1) | CL2016002835A1 (el) |
| CY (1) | CY1121550T1 (el) |
| DK (1) | DK3143016T3 (el) |
| ES (1) | ES2712401T3 (el) |
| HR (1) | HRP20190432T1 (el) |
| HU (1) | HUE041838T2 (el) |
| IL (1) | IL248529B (el) |
| JO (1) | JO3668B1 (el) |
| LT (1) | LT3143016T (el) |
| MA (1) | MA39915B1 (el) |
| ME (1) | ME03417B (el) |
| MX (2) | MX2016014997A (el) |
| MY (1) | MY195081A (el) |
| PE (1) | PE20170384A1 (el) |
| PH (1) | PH12016502249A1 (el) |
| PL (1) | PL3143016T3 (el) |
| PT (1) | PT3143016T (el) |
| RS (1) | RS58400B1 (el) |
| RU (1) | RU2707730C2 (el) |
| SG (1) | SG11201609693XA (el) |
| SI (1) | SI3143016T1 (el) |
| TR (1) | TR201902328T4 (el) |
| TW (1) | TWI634115B (el) |
| UA (1) | UA119458C2 (el) |
| WO (1) | WO2015175594A1 (el) |
| ZA (1) | ZA201607354B (el) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3910073B1 (en) | 2015-09-01 | 2024-03-06 | Eisai R&D Management Co., Ltd. | Splice variants associated with neomorphic sf3b1 mutants |
| EP3377485B1 (en) * | 2015-11-18 | 2019-09-25 | Eisai R&D Management Co., Ltd. | A solid state form of pladienolide pyridine compounds and methods of use |
| SG11201907887SA (en) | 2017-03-15 | 2019-09-27 | Eisai Co Ltd | Spliceosome mutations and uses thereof |
| JP2021505526A (ja) | 2017-10-31 | 2021-02-18 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 少なくとも１つのスプライソソームモジュレーターと、ｂｃｌ２阻害剤、ｂｃｌ２／ｂｃｌｘｌ阻害剤及びｂｃｌｘｌ阻害剤から選択される少なくとも１つの阻害剤とを含む組合せ、並びに使用の方法 |
| IL303335A (en) * | 2018-04-09 | 2023-07-01 | Eisai R&D Man Co Ltd | Palladianolide compounds and their use |
| JP7334181B2 (ja) | 2018-04-12 | 2023-08-28 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 癌治療用のスプライセオソームターゲティング薬剤としてのプラジエノライド誘導体 |
| EP3801523A2 (en) * | 2018-06-01 | 2021-04-14 | Eisai R&D Management Co., Ltd. | Methods of using splicing modulators |
| IL262658A (en) * | 2018-10-28 | 2020-04-30 | Memorial Sloan Kettering Cancer Center | Prevention of age related clonal hematopoiesis and diseases associated therewith |
| CA3199753A1 (en) | 2020-11-04 | 2022-05-12 | Eisai R&D Management Co., Ltd. | Biomarkers for myelodysplastic syndrome (mds) and methods of using the same |
| EP4361136A1 (en) * | 2021-06-18 | 2024-05-01 | Universidad De Córdoba | Compound for the treatment of glioblastoma |
| CN113876771B (zh) * | 2021-11-12 | 2022-09-23 | 中国医学科学院基础医学研究所 | 一种靶向pabpc1的小分子药物及其在慢性髓系白血病中的应用 |
| WO2023131866A1 (en) | 2022-01-05 | 2023-07-13 | Eisai R&D Management Co., Ltd. | Biomarkers for myelodysplastic syndrome (mds) and methods of using the same |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI311558B (en) * | 2001-02-01 | 2009-07-01 | Mercian Corporatio | Novel physiologically active substance |
| TWI334866B (en) | 2002-05-29 | 2010-12-21 | Mercian Corp | Novel physiologically active substances |
| NZ537830A (en) | 2002-07-31 | 2007-12-21 | Mercian Corp | Novel physiologically active substances |
| EP1541570A4 (en) | 2002-07-31 | 2008-05-21 | Mercian Corp | NEW PHYSIOLOGICALLY ACTIVE SUBSTANCE |
| AU2003285012A1 (en) | 2002-10-24 | 2004-05-13 | Sepracor, Inc. | Compositions comprising zopiclone derivatives and methods of making and using the same |
| US7745198B2 (en) | 2002-11-29 | 2010-06-29 | Mercian Corporation | Method of producing macrolide compound |
| JP4441489B2 (ja) | 2003-11-27 | 2010-03-31 | メルシャン株式会社 | マクロライド系化合物の水酸化に関与するｄｎａ |
| WO2005052156A1 (ja) | 2003-11-28 | 2005-06-09 | Kanagawa Academy Of Science And Technology | 肝癌の検出方法及び肝癌診断薬並びに癌治療薬 |
| US20070199741A1 (en) | 2004-07-02 | 2007-08-30 | Kenji Noumi | Combined Weighing Apparatus |
| CN1977046A (zh) | 2004-07-20 | 2007-06-06 | 卫材R&D管理有限公司 | 编码参与普拉地内酯生物合成的多肽的dna |
| TW200716744A (en) * | 2005-05-26 | 2007-05-01 | Eisai R&D Man Co Ltd | Genetically modified microorganism and process for production of macrolide compound using the microorganism |
| CN101282967B (zh) | 2005-10-13 | 2011-01-26 | 卫材R&D管理有限公司 | 普拉二烯内酯b和普拉二烯内酯d的全合成 |
| WO2008111464A1 (ja) * | 2007-03-05 | 2008-09-18 | Eisai R & D Management Co., Ltd. | スプライシング異常を指標とする抗ガン剤の作用検定方法 |
| US20080312317A1 (en) | 2007-04-12 | 2008-12-18 | Eisai R&D Management Co., Ltd. | 12 membered-ring macrolactam derivatives |
-
2015
- 2015-05-13 WO PCT/US2015/030464 patent/WO2015175594A1/en active Application Filing
- 2015-05-13 RS RS20190233A patent/RS58400B1/sr unknown
- 2015-05-13 DK DK15727125.5T patent/DK3143016T3/en active
- 2015-05-13 CN CN201580025344.0A patent/CN107074827B/zh active Active
- 2015-05-13 EP EP18210019.8A patent/EP3514154B1/en active Active
- 2015-05-13 RU RU2016148887A patent/RU2707730C2/ru active
- 2015-05-13 MA MA39915A patent/MA39915B1/fr unknown
- 2015-05-13 JO JOP/2015/0113A patent/JO3668B1/ar active
- 2015-05-13 PE PE2016002233A patent/PE20170384A1/es unknown
- 2015-05-13 MY MYPI2016001944A patent/MY195081A/en unknown
- 2015-05-13 PT PT15727125T patent/PT3143016T/pt unknown
- 2015-05-13 SI SI201530641T patent/SI3143016T1/sl unknown
- 2015-05-13 HU HUE15727125A patent/HUE041838T2/hu unknown
- 2015-05-13 TR TR2019/02328T patent/TR201902328T4/tr unknown
- 2015-05-13 ES ES15727125T patent/ES2712401T3/es active Active
- 2015-05-13 KR KR1020167016648A patent/KR101710318B1/ko active IP Right Grant
- 2015-05-13 AR ARP150101485A patent/AR100431A1/es unknown
- 2015-05-13 CA CA2947754A patent/CA2947754C/en active Active
- 2015-05-13 SG SG11201609693XA patent/SG11201609693XA/en unknown
- 2015-05-13 ME MEP-2019-81A patent/ME03417B/me unknown
- 2015-05-13 US US14/710,687 patent/US9481669B2/en active Active
- 2015-05-13 KR KR1020177004442A patent/KR102146726B1/ko active IP Right Grant
- 2015-05-13 MX MX2016014997A patent/MX2016014997A/es active IP Right Grant
- 2015-05-13 AU AU2015259237A patent/AU2015259237B2/en active Active
- 2015-05-13 LT LTEP15727125.5T patent/LT3143016T/lt unknown
- 2015-05-13 MX MX2020004476A patent/MX2020004476A/es unknown
- 2015-05-13 BR BR112016026638-2A patent/BR112016026638B1/pt active IP Right Grant
- 2015-05-13 PL PL15727125T patent/PL3143016T3/pl unknown
- 2015-05-13 TW TW104115293A patent/TWI634115B/zh active
- 2015-05-13 UA UAA201612731A patent/UA119458C2/uk unknown
- 2015-05-13 EP EP15727125.5A patent/EP3143016B1/en active Active
- 2015-05-13 JP JP2016526218A patent/JP6067943B1/ja active Active
-
2016
- 2016-10-25 ZA ZA2016/07354A patent/ZA201607354B/en unknown
- 2016-10-26 IL IL24852916A patent/IL248529B/en active IP Right Grant
- 2016-11-08 CL CL2016002835A patent/CL2016002835A1/es unknown
- 2016-11-11 PH PH12016502249A patent/PH12016502249A1/en unknown
-
2019
- 2019-02-22 CY CY20191100228T patent/CY1121550T1/el unknown
- 2019-03-04 HR HRP20190432TT patent/HRP20190432T1/hr unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1121550T1 (el) | Ενωσεις πυριδινης πλαδιενολιδης και μεθοδοι χρησης | |
| CY1124959T1 (el) | Αναστολεις λυσινης ειδικης απομεθυλασης-1 | |
| CY1120361T1 (el) | Αναστολεις 2,3-διοξυγενασης ινδολαμινης (ido) | |
| CY1124407T1 (el) | Ενωσεις αναστολεα αυτοταξινης | |
| CY1122886T1 (el) | Αναστολεις βρωμοεπικρατειων | |
| CY1120969T1 (el) | Παραγωγα κινοξαλινης χρησιμα ως τροποποιητες fgfr κινασης | |
| CY1125127T1 (el) | Αναστολεις λυσινης ειδικης απομεθυλασης-1 | |
| CY1124055T1 (el) | Ετεροκυκλικες ενωσεις ως ανοσοδιαμορφωτες | |
| CY1121299T1 (el) | Υποκατεστημενες τρικυκλικες ενωσεις ως αναστολεις fgfr | |
| CY1122415T1 (el) | Κυκλοπροπυλαμινες ως lsd1 αναστολεις | |
| CY1121850T1 (el) | Διαρυλο μακροκυκλοι ως ρυθμιστες των πρωτεϊνικων kinασων | |
| CY1122314T1 (el) | Κυκλοπροπυλαμινες ως αναστολεις lsd1 | |
| CY1120556T1 (el) | Δικυκλικα ετεροκυκλα ως αναστολεις fgfr | |
| CY1124798T1 (el) | Υποκατεστημενα παραγωγα καρβονουκλεοζιδιων χρησιμα ως παραγοντες κατα των καρκινων | |
| CY1119476T1 (el) | Αναστολεις της απομεθυλασης ιστονης | |
| CY1119901T1 (el) | Αναστολεις απομεθυλασων ιστονων | |
| CY1120373T1 (el) | Συνθεσεις που περιλαμβανουν βακτηριακα στελεχη | |
| CY1121517T1 (el) | Μη φουκοζυλιωμενα αντισωματα enanti-fgfr2iiib | |
| CY1124918T1 (el) | Ρυθμιστες ccr2 | |
| WO2018112365A3 (en) | Methods of treating colorectal cancer and melanoma using parabacteroides goldsteinii | |
| CY1123906T1 (el) | Αναστολεις απομεθυλασης ιστονης | |
| CY1119199T1 (el) | Αναστολεις cdc7 | |
| TW201613648A (en) | Compounds and compositions for immunotherapy | |
| EA201890754A1 (ru) | Соединения и способы их применения | |
| CY1125150T1 (el) | Ενωσεις φαινυλο-2-υδροξυ-ακετυλαμινο-2-μεθυλο-φαινυλιου |