EA202191104A1 - Производные аминопиридина/пиразина в качестве ингибиторов ctps1 - Google Patents
Производные аминопиридина/пиразина в качестве ингибиторов ctps1Info
- Publication number
- EA202191104A1 EA202191104A1 EA202191104A EA202191104A EA202191104A1 EA 202191104 A1 EA202191104 A1 EA 202191104A1 EA 202191104 A EA202191104 A EA 202191104A EA 202191104 A EA202191104 A EA 202191104A EA 202191104 A1 EA202191104 A1 EA 202191104A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- aminopyridine
- pyrazine derivatives
- ctps1 inhibitors
- ctps1
- inhibitors
- Prior art date
Links
- 102100039866 CTP synthase 1 Human genes 0.000 title 1
- 101001101919 Homo sapiens CTP synthase 1 Proteins 0.000 title 1
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical class C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 title 1
- 150000003927 aminopyridines Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Abstract
Соединение формулы (I)и родственные аспекты.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18202136 | 2018-10-23 | ||
| PCT/EP2019/057320 WO2019180244A1 (en) | 2018-03-23 | 2019-03-22 | Aminopyrimidine derivatives as ctps1 inhibitors |
| PCT/EP2019/078848 WO2020083975A1 (en) | 2018-10-23 | 2019-10-23 | Aminopyrimidine/pyrazine derivatives as ctps1 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202191104A1 true EA202191104A1 (ru) | 2021-07-19 |
Family
ID=63965420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202191104A EA202191104A1 (ru) | 2018-10-23 | 2019-10-23 | Производные аминопиридина/пиразина в качестве ингибиторов ctps1 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20210387965A1 (ru) |
| EP (1) | EP3870574B1 (ru) |
| JP (1) | JP7308263B2 (ru) |
| CN (1) | CN112839938B (ru) |
| AU (1) | AU2019367191B2 (ru) |
| BR (1) | BR112021005986A2 (ru) |
| CA (1) | CA3115568C (ru) |
| CR (1) | CR20210265A (ru) |
| DK (1) | DK3870574T3 (ru) |
| EA (1) | EA202191104A1 (ru) |
| ES (1) | ES2941981T3 (ru) |
| FI (1) | FI3870574T3 (ru) |
| HR (1) | HRP20230328T1 (ru) |
| HU (1) | HUE061652T2 (ru) |
| IL (1) | IL282386B2 (ru) |
| LT (1) | LT3870574T (ru) |
| MX (1) | MX2021004659A (ru) |
| PL (1) | PL3870574T3 (ru) |
| PT (1) | PT3870574T (ru) |
| RS (1) | RS64081B1 (ru) |
| SG (1) | SG11202103823PA (ru) |
| SI (1) | SI3870574T1 (ru) |
| WO (1) | WO2020083975A1 (ru) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11655246B2 (en) | 2017-11-30 | 2023-05-23 | Step Pharma S.A.S. | Aminothiazole compounds as inhibitors of CTPS1 |
| US11505547B2 (en) | 2017-11-30 | 2022-11-22 | Step Pharma S.A.S. | Compounds |
| EP3980410A1 (en) | 2019-06-04 | 2022-04-13 | Step Pharma S.A.S. | N-(4-(5-chloropyridin-3-yl)phenyl)-2-(2-(cyclopropanesulfonamido)pyrimidin-4-yl) butanamide derivatives and related compounds as human ctps1 inhibitors for the treatment of proliferative diseases |
| EP3980411A1 (en) | 2019-06-04 | 2022-04-13 | Step Pharma S.A.S. | N-(5-(6-ethoxypyrazin-2-yl)pyridin-2-yl)-4-(2-(methylsulfonamido)pyrimidin-4-yl) tetrahydro-2h-pyran-4-carboxamide derivatives and related compounds as human ctps1 inhibitors for the treatment of proliferative diseases |
| EP4041715A1 (en) | 2019-09-20 | 2022-08-17 | Step Pharma S.A.S. | Sulfonamide inhibitors as ctps 1 inhibitors |
| WO2021053402A2 (en) | 2019-09-20 | 2021-03-25 | Step Pharma S.A.S. | Compounds |
| WO2023166077A1 (en) | 2022-03-01 | 2023-09-07 | Step Pharma S.A.S. | Combination of a ctps1 inhibitor and a atr inhibitor in cancer therapy |
| WO2023166076A1 (en) | 2022-03-01 | 2023-09-07 | Step Pharma S.A.S. | Combinations of ctps1 and bcl2 inhibitors for cancer |
| WO2023166080A1 (en) | 2022-03-01 | 2023-09-07 | Step Pharma S.A.S. | Combination treatments comprising a ctps1 inhibitor and a wee1 inhibitor |
| WO2023166078A1 (en) | 2022-03-01 | 2023-09-07 | Step Pharma S.A.S. | Combination treatments comprising a ctps1 inhibitor and a chek1 inhibitor |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1659113A1 (en) * | 2004-11-08 | 2006-05-24 | Evotec AG | Inhibitors of 11beta-hydroxy steroid dehydrogenase type 1 (11beta-HSD1) |
| CA2707492A1 (en) | 2007-12-13 | 2009-06-18 | Amgen Inc. | Gamma secretase modulators |
| EP2986287A2 (en) | 2013-04-18 | 2016-02-24 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods and pharmaceutical compositions (ctps 1 inhibitors, e.g. norleucine) for inhibiting t cell proliferation in a subject in need thereof |
| WO2014186435A2 (en) | 2013-05-14 | 2014-11-20 | University Of Georgia Research Foundation, Inc. | Compositions and methods for reducing neointima formation |
| US11655246B2 (en) | 2017-11-30 | 2023-05-23 | Step Pharma S.A.S. | Aminothiazole compounds as inhibitors of CTPS1 |
| US11505547B2 (en) | 2017-11-30 | 2022-11-22 | Step Pharma S.A.S. | Compounds |
| WO2019180244A1 (en) | 2018-03-23 | 2019-09-26 | Step Pharma S.A.S. | Aminopyrimidine derivatives as ctps1 inhibitors |
| CN111868051B (zh) | 2018-03-23 | 2024-04-09 | 斯泰普制药股份公司 | 作为ctps1抑制剂的氨基嘧啶衍生物 |
| US20230192673A1 (en) * | 2018-06-04 | 2023-06-22 | Step Pharma S.A.S. | Compounds |
-
2019
- 2019-10-23 US US17/287,137 patent/US20210387965A1/en active Pending
- 2019-10-23 JP JP2021522085A patent/JP7308263B2/ja active Active
- 2019-10-23 MX MX2021004659A patent/MX2021004659A/es unknown
- 2019-10-23 AU AU2019367191A patent/AU2019367191B2/en active Active
- 2019-10-23 CR CR20210265A patent/CR20210265A/es unknown
- 2019-10-23 CA CA3115568A patent/CA3115568C/en active Active
- 2019-10-23 BR BR112021005986-5A patent/BR112021005986A2/pt unknown
- 2019-10-23 LT LTEPPCT/EP2019/078848T patent/LT3870574T/lt unknown
- 2019-10-23 IL IL282386A patent/IL282386B2/en unknown
- 2019-10-23 WO PCT/EP2019/078848 patent/WO2020083975A1/en unknown
- 2019-10-23 PL PL19789997.4T patent/PL3870574T3/pl unknown
- 2019-10-23 CN CN201980063914.3A patent/CN112839938B/zh active Active
- 2019-10-23 PT PT197899974T patent/PT3870574T/pt unknown
- 2019-10-23 SI SI201930504T patent/SI3870574T1/sl unknown
- 2019-10-23 SG SG11202103823PA patent/SG11202103823PA/en unknown
- 2019-10-23 HR HRP20230328TT patent/HRP20230328T1/hr unknown
- 2019-10-23 EP EP19789997.4A patent/EP3870574B1/en active Active
- 2019-10-23 ES ES19789997T patent/ES2941981T3/es active Active
- 2019-10-23 RS RS20230239A patent/RS64081B1/sr unknown
- 2019-10-23 DK DK19789997.4T patent/DK3870574T3/da active
- 2019-10-23 EA EA202191104A patent/EA202191104A1/ru unknown
- 2019-10-23 HU HUE19789997A patent/HUE061652T2/hu unknown
- 2019-10-23 FI FIEP19789997.4T patent/FI3870574T3/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| CN112839938A (zh) | 2021-05-25 |
| MX2021004659A (es) | 2021-05-28 |
| ES2941981T3 (es) | 2023-05-29 |
| CA3115568C (en) | 2023-07-11 |
| FI3870574T3 (fi) | 2023-04-03 |
| BR112021005986A2 (pt) | 2021-06-29 |
| SG11202103823PA (en) | 2021-05-28 |
| PL3870574T3 (pl) | 2023-05-02 |
| CN112839938B (zh) | 2023-07-07 |
| CR20210265A (es) | 2021-08-24 |
| EP3870574B1 (en) | 2023-01-04 |
| HRP20230328T1 (hr) | 2023-06-09 |
| EP3870574A1 (en) | 2021-09-01 |
| JP7308263B2 (ja) | 2023-07-13 |
| AU2019367191B2 (en) | 2022-09-08 |
| IL282386A (en) | 2021-06-30 |
| HUE061652T2 (hu) | 2023-07-28 |
| JP2022512793A (ja) | 2022-02-07 |
| RS64081B1 (sr) | 2023-04-28 |
| DK3870574T3 (da) | 2023-04-11 |
| IL282386B1 (en) | 2023-10-01 |
| LT3870574T (lt) | 2023-04-11 |
| IL282386B2 (en) | 2024-02-01 |
| PT3870574T (pt) | 2023-03-16 |
| AU2019367191A1 (en) | 2021-04-29 |
| CA3115568A1 (en) | 2020-04-30 |
| US20210387965A1 (en) | 2021-12-16 |
| WO2020083975A1 (en) | 2020-04-30 |
| SI3870574T1 (sl) | 2023-05-31 |
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