CR20210265A - Derivados de aminopirimidina/pirazina como inhibidores de ctps1 - Google Patents

Derivados de aminopirimidina/pirazina como inhibidores de ctps1

Info

Publication number
CR20210265A
CR20210265A CR20210265A CR20210265A CR20210265A CR 20210265 A CR20210265 A CR 20210265A CR 20210265 A CR20210265 A CR 20210265A CR 20210265 A CR20210265 A CR 20210265A CR 20210265 A CR20210265 A CR 20210265A
Authority
CR
Costa Rica
Prior art keywords
aminopyrimidine
pyrazine derivatives
ctps1 inhibitors
ctps1
inhibitors
Prior art date
Application number
CR20210265A
Other languages
English (en)
Inventor
Andrew Novak
Emma Blackham
Joseph Wrigglesworth
David Cousin
Louise Birch
Abdul Quddus
Saleh Ahmed
Geraint Jones
Lorna Duffy
Pascal George
Original Assignee
Step Pharma S A S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2018/086617 external-priority patent/WO2019179652A1/en
Priority claimed from PCT/EP2019/057320 external-priority patent/WO2019180244A1/en
Application filed by Step Pharma S A S filed Critical Step Pharma S A S
Publication of CR20210265A publication Critical patent/CR20210265A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pyridine Compounds (AREA)

Abstract

Compuestos de fórmula (I) y aspectos relacionados.
CR20210265A 2018-10-23 2019-10-23 Derivados de aminopirimidina/pirazina como inhibidores de ctps1 CR20210265A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP18202136 2018-10-23
PCT/EP2018/086617 WO2019179652A1 (en) 2018-03-23 2018-12-21 Aminopyrimidine derivatives as ctps1 inhibitors
PCT/EP2019/057320 WO2019180244A1 (en) 2018-03-23 2019-03-22 Aminopyrimidine derivatives as ctps1 inhibitors
PCT/EP2019/078848 WO2020083975A1 (en) 2018-10-23 2019-10-23 Aminopyrimidine/pyrazine derivatives as ctps1 inhibitors

Publications (1)

Publication Number Publication Date
CR20210265A true CR20210265A (es) 2021-08-24

Family

ID=63965420

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20210265A CR20210265A (es) 2018-10-23 2019-10-23 Derivados de aminopirimidina/pirazina como inhibidores de ctps1

Country Status (23)

Country Link
US (1) US11987573B2 (es)
EP (1) EP3870574B1 (es)
JP (1) JP7308263B2 (es)
CN (1) CN112839938B (es)
AU (1) AU2019367191B2 (es)
BR (1) BR112021005986A2 (es)
CA (1) CA3115568C (es)
CR (1) CR20210265A (es)
DK (1) DK3870574T3 (es)
EA (1) EA202191104A1 (es)
ES (1) ES2941981T3 (es)
FI (1) FI3870574T3 (es)
HR (1) HRP20230328T1 (es)
HU (1) HUE061652T2 (es)
IL (1) IL282386B2 (es)
LT (1) LT3870574T (es)
MX (1) MX2021004659A (es)
PL (1) PL3870574T3 (es)
PT (1) PT3870574T (es)
RS (1) RS64081B1 (es)
SG (1) SG11202103823PA (es)
SI (1) SI3870574T1 (es)
WO (1) WO2020083975A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019106156A1 (en) 2017-11-30 2019-06-06 Step Pharma S.A.S. Compounds
EP3717465A1 (en) 2017-11-30 2020-10-07 Step Pharma S.A.S. Compounds
WO2020245665A1 (en) 2019-06-04 2020-12-10 Step Pharma S.A.S. N-(4-(5-chloropyridin-3-yl)phenyl)-2-(2-(cyclopropanesulfonamido)pyrimidin-4-yl) butanamide derivatives and related compounds as human ctps1 inhibitors for the treatment of proliferative diseases
WO2020245664A1 (en) 2019-06-04 2020-12-10 Step Pharma S.A.S. N-(5-(6-ethoxypyrazin-2-yl)pyridin-2-yl)-4-(2-(methylsulfonamido)pyrimidin-4-yl) tetrahydro-2h-pyran-4-carboxamide derivatives and related compounds as human ctps1 inhibitors for the treatment of proliferative diseases
US20230002352A1 (en) 2019-09-20 2023-01-05 Step Pharma S.A.S. Sulfonamide derivatives as ctps1 inhibitors
WO2021053403A1 (en) 2019-09-20 2021-03-25 Step Pharma S.A.S. Sulfonamide inhibitors as ctps1 inhibitors
WO2023166078A1 (en) 2022-03-01 2023-09-07 Step Pharma S.A.S. Combination treatments comprising a ctps1 inhibitor and a chek1 inhibitor
WO2023166076A1 (en) 2022-03-01 2023-09-07 Step Pharma S.A.S. Combinations of ctps1 and bcl2 inhibitors for cancer
WO2023166080A1 (en) 2022-03-01 2023-09-07 Step Pharma S.A.S. Combination treatments comprising a ctps1 inhibitor and a wee1 inhibitor
WO2023166077A1 (en) 2022-03-01 2023-09-07 Step Pharma S.A.S. Combination of a ctps1 inhibitor and a atr inhibitor in cancer therapy

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GB1575803A (en) 1976-03-09 1980-10-01 Fujisawa Pharmaceutical Co 3,7 disubstituted 3 cephem 4 carboxylic acid compounds andprocesses for the preparation thereof
GB1555007A (en) 1976-05-25 1979-11-07 Fujisawa Pharmaceutical Co Intermediates in the preparation of substituted cepham carboxylic acid derivatives and the preparation thereof
MXPA03001535A (es) 2000-08-21 2004-12-13 Pacific Corp Derivados de tiourea novedosos y las composiciones farmaceuticas que contienen los mismos.
DE60140263D1 (de) 2000-09-25 2009-12-03 Actelion Pharmaceuticals Ltd Arylalkanen-sulfonamiden mit endothelin-antagonistischer aktivität
US20030158218A1 (en) 2001-12-21 2003-08-21 Nantermet Philippe G. Thrombin inhibitors
EA012584B1 (ru) 2004-07-26 2009-10-30 Лаборатуар Сероно Са Производные n-гидроксиамида и их применение
EP1659113A1 (en) 2004-11-08 2006-05-24 Evotec AG Inhibitors of 11beta-hydroxy steroid dehydrogenase type 1 (11beta-HSD1)
AR063706A1 (es) 2006-09-11 2009-02-11 Cgi Pharmaceuticals Inc Determinadas amidas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmaceuticas que las comprenden.
CN101896461A (zh) * 2007-12-13 2010-11-24 安姆根有限公司 γ分泌酶调节剂
KR101097312B1 (ko) 2009-08-10 2011-12-23 삼성모바일디스플레이주식회사 유기 발광 소자
US9359345B2 (en) 2012-12-13 2016-06-07 Hoffmann-La Roche Inc. Thiazole derivatives as inhibitors of Bruton's tyrosine kinase
JP2016028795A (ja) 2013-03-28 2016-03-03 国立研究開発法人科学技術振興機構 触媒金属ナノ粒子含有複合体及びその利用
WO2014170435A2 (en) * 2013-04-18 2014-10-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for inhibiting lymphocyte proliferation in a subject in need thereof
WO2014186435A2 (en) * 2013-05-14 2014-11-20 University Of Georgia Research Foundation, Inc. Compositions and methods for reducing neointima formation
GB201322333D0 (en) 2013-12-17 2014-01-29 Agency Science Tech & Res WNT pathway modulators
CN104262071A (zh) 2014-10-16 2015-01-07 中国科学院山西煤炭化学研究所 一种联苯类化合物的光催化合成方法
EP3717465A1 (en) 2017-11-30 2020-10-07 Step Pharma S.A.S. Compounds
WO2019106156A1 (en) 2017-11-30 2019-06-06 Step Pharma S.A.S. Compounds
KR20200135463A (ko) 2018-03-23 2020-12-02 스텝 파마 에스.에이.에스. Ctps1 억제제로서 아미노피리미딘 유도체
WO2019180244A1 (en) 2018-03-23 2019-09-26 Step Pharma S.A.S. Aminopyrimidine derivatives as ctps1 inhibitors
US20230192673A1 (en) * 2018-06-04 2023-06-22 Step Pharma S.A.S. Compounds
JP2023546996A (ja) 2020-10-23 2023-11-08 ニンバス クロソー， インコーポレイテッド Ｃｔｐｓ１阻害剤およびその使用

Also Published As

Publication number Publication date
CA3115568A1 (en) 2020-04-30
US11987573B2 (en) 2024-05-21
PT3870574T (pt) 2023-03-16
JP7308263B2 (ja) 2023-07-13
EP3870574A1 (en) 2021-09-01
HRP20230328T1 (hr) 2023-06-09
CN112839938B (zh) 2023-07-07
WO2020083975A1 (en) 2020-04-30
AU2019367191B2 (en) 2022-09-08
BR112021005986A2 (pt) 2021-06-29
SG11202103823PA (en) 2021-05-28
EA202191104A1 (ru) 2021-07-19
HUE061652T2 (hu) 2023-07-28
EP3870574B1 (en) 2023-01-04
DK3870574T3 (da) 2023-04-11
RS64081B1 (sr) 2023-04-28
US20210387965A1 (en) 2021-12-16
AU2019367191A1 (en) 2021-04-29
IL282386B1 (en) 2023-10-01
LT3870574T (lt) 2023-04-11
IL282386B2 (en) 2024-02-01
MX2021004659A (es) 2021-05-28
IL282386A (en) 2021-06-30
JP2022512793A (ja) 2022-02-07
PL3870574T3 (pl) 2023-05-02
SI3870574T1 (sl) 2023-05-31
CN112839938A (zh) 2021-05-25
ES2941981T3 (es) 2023-05-29
FI3870574T3 (fi) 2023-04-03
CA3115568C (en) 2023-07-11

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