MX2020012718A - Derivados de benzodiazepinas novedosos y usos de los mismos. - Google Patents

Derivados de benzodiazepinas novedosos y usos de los mismos.

Info

Publication number
MX2020012718A
MX2020012718A MX2020012718A MX2020012718A MX2020012718A MX 2020012718 A MX2020012718 A MX 2020012718A MX 2020012718 A MX2020012718 A MX 2020012718A MX 2020012718 A MX2020012718 A MX 2020012718A MX 2020012718 A MX2020012718 A MX 2020012718A
Authority
MX
Mexico
Prior art keywords
benzodiazepine derivatives
novel benzodiazepine
novel
derivatives
methods
Prior art date
Application number
MX2020012718A
Other languages
English (en)
Inventor
Taekyo Park
Jongun Cho
Doohwan Jung
Sunyoung Kim
Jaeho Lee
Suho Park
Donghoon Seo
Sangkwang Lee
Sanghyeon Yun
Okku Park
Beomseok Seo
Sung Ho Woo
Hyang Sook Lee
Sena Kim
Minah Seol
Original Assignee
Intocell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intocell Inc filed Critical Intocell Inc
Publication of MX2020012718A publication Critical patent/MX2020012718A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente descripción proporciona compuestos y composiciones capaces de extender la vida, y métodos para su uso.
MX2020012718A 2018-05-29 2019-05-29 Derivados de benzodiazepinas novedosos y usos de los mismos. MX2020012718A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862677498P 2018-05-29 2018-05-29
PCT/IB2019/000691 WO2019229536A2 (en) 2018-05-29 2019-05-29 Novel benzodiazepine derivatives and uses thereof

Publications (1)

Publication Number Publication Date
MX2020012718A true MX2020012718A (es) 2021-02-16

Family

ID=68692822

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020012718A MX2020012718A (es) 2018-05-29 2019-05-29 Derivados de benzodiazepinas novedosos y usos de los mismos.

Country Status (12)

Country Link
US (2) US11084801B2 (es)
EP (1) EP3802546A4 (es)
JP (1) JP7465819B2 (es)
KR (1) KR20210003938A (es)
CN (2) CN113444111A (es)
AU (2) AU2019276833A1 (es)
BR (1) BR112020023623A2 (es)
CA (1) CA3100141A1 (es)
EA (1) EA202092909A1 (es)
IL (1) IL278973A (es)
MX (1) MX2020012718A (es)
WO (1) WO2019229536A2 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3802546A4 (en) 2018-05-29 2021-12-29 Intocell, Inc. Novel benzodiazepine derivatives and uses thereof
US20230039858A1 (en) * 2019-12-02 2023-02-09 Intocell, Inc. Compositions and methods related to molecular conjugation
CN114805432A (zh) * 2022-03-03 2022-07-29 西北工业大学 新型可光催化剪切的羧酸保护基及其氨基酸衍生物的制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843937A (en) 1996-05-23 1998-12-01 Panorama Research, Inc. DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents
GB0819095D0 (en) 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
EP3360879A1 (en) 2009-02-05 2018-08-15 ImmunoGen, Inc. Benzodiazepine derivatives as cytotoxic agents
KR101891859B1 (ko) * 2011-10-14 2018-08-24 메디뮨 리미티드 피롤로벤조디아제핀
EA036202B1 (ru) 2011-10-14 2020-10-14 Сиэтл Дженетикс, Инк. Пирролбензодиазепины и конъюгаты направленного действия
EP2887965A1 (en) * 2012-08-22 2015-07-01 ImmunoGen, Inc. Cytotoxic benzodiazepine derivatives
US10131682B2 (en) 2012-11-24 2018-11-20 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
CA2935077C (en) * 2013-12-27 2022-03-15 Geoffrey C. Winters Sulfonamide-containing linkage systems for drug conjugates
EP3160513B1 (en) 2014-06-30 2020-02-12 Glykos Finland Oy Saccharide derivative of a toxic payload and antibody conjugates thereof
BR112017014599A2 (pt) * 2015-01-14 2018-01-16 Bristol-Myers Squibb Company dímeros de benzodiazepina, conjugados dos mesmos, e métodos de preparação e uso
WO2016115201A1 (en) 2015-01-14 2016-07-21 Bristol-Myers Squibb Company Heteroarylene-bridged benzodiazepine dimers, conjugates thereof, and methods of making and using
EP3662933A1 (en) 2015-03-18 2020-06-10 Seattle Genetics, Inc. Cd48 antibodies and conjugates thereof
US9504694B2 (en) * 2015-03-19 2016-11-29 Cellerant Therapeutics, Inc. Isoquinolidinobenzodiazepines
CA3024679A1 (en) 2016-05-20 2017-11-23 Abbvie Stemcentrx Llc Anti-dll3 drug conjugates for treating tumors at risk of neuroendocrine transition
WO2018053552A2 (en) * 2016-09-19 2018-03-22 Cellerant Therapeutics, Inc. Isoquinolidinobenzodiazepines
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
US11730822B2 (en) * 2017-03-24 2023-08-22 Seagen Inc. Process for the preparation of glucuronide drug-linkers and intermediates thereof
WO2018195243A1 (en) 2017-04-20 2018-10-25 Immunogen, Inc. Cytotoxic benzodiazepine derivatives and conjugates thereof
US11753431B2 (en) * 2017-07-04 2023-09-12 Intocell, Inc. Compounds comprising cleavable linker and uses thereof
GB201714115D0 (en) * 2017-09-04 2017-10-18 Femtogenix Ltd Cytotoxic agents
EP3802546A4 (en) 2018-05-29 2021-12-29 Intocell, Inc. Novel benzodiazepine derivatives and uses thereof
WO2020089687A2 (en) 2018-10-31 2020-05-07 Intocell, Inc. Fused heterocyclic benzodiazepine derivatives and uses thereof
KR102503143B1 (ko) 2019-03-06 2023-02-24 주식회사 레고켐 바이오사이언스 인간 dlk1에 대한 항체를 포함하는 항체 약물 접합체 및 이의 용도
BR112022026401A2 (pt) 2020-06-26 2023-03-14 Intocell Inc Conjugados anticorpo-fármaco compreendendo anticorpos anti-b7-h3

Also Published As

Publication number Publication date
EA202092909A1 (ru) 2021-04-07
US11084801B2 (en) 2021-08-10
CN113444111A (zh) 2021-09-28
WO2019229536A2 (en) 2019-12-05
CA3100141A1 (en) 2019-12-05
BR112020023623A2 (pt) 2021-02-17
KR20210003938A (ko) 2021-01-12
JP7465819B2 (ja) 2024-04-11
AU2023203485A1 (en) 2023-07-06
CN112166115A (zh) 2021-01-01
IL278973A (en) 2021-01-31
EP3802546A4 (en) 2021-12-29
US20220162190A1 (en) 2022-05-26
US11807628B2 (en) 2023-11-07
JP2021525730A (ja) 2021-09-27
WO2019229536A3 (en) 2020-03-05
US20190367488A1 (en) 2019-12-05
EP3802546A2 (en) 2021-04-14
AU2019276833A1 (en) 2020-11-26

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