BR112022026401A2 - Conjugados anticorpo-fármaco compreendendo anticorpos anti-b7-h3 - Google Patents

Conjugados anticorpo-fármaco compreendendo anticorpos anti-b7-h3

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Publication number
BR112022026401A2
BR112022026401A2 BR112022026401A BR112022026401A BR112022026401A2 BR 112022026401 A2 BR112022026401 A2 BR 112022026401A2 BR 112022026401 A BR112022026401 A BR 112022026401A BR 112022026401 A BR112022026401 A BR 112022026401A BR 112022026401 A2 BR112022026401 A2 BR 112022026401A2
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BR
Brazil
Prior art keywords
antibody
antibodies
drug conjugates
antigen
active agents
Prior art date
Application number
BR112022026401A
Other languages
English (en)
Inventor
Park Taekyo
Kim Sunyoung
Park Suho
Jung Doohwan
Seo Donghoon
Lee Sangkwang
Yun Sanghyeon
HA Jihyeon
Sook Lee Hyang
Park Okku
Seo Beomseok
Kim Sena
Seol Minah
SONG Jina
Ho Woo Sung
Cho Jongun
Lee Jaeho
Mi Lee Hyun
Eum Park Jae
Song Youngja
Lee Eunjin
Ju Lee Hyun
Shim Eun-Young
Ko Yunjung
Lee Minju
Woo Park Young
Rew Yosup
Original Assignee
Intocell Inc
Y Biologics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intocell Inc, Y Biologics Inc filed Critical Intocell Inc
Publication of BR112022026401A2 publication Critical patent/BR112022026401A2/pt

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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

CONJUGADOS ANTICORPO-FÁRMACO COMPREENDENDO ANTICORPOS ANTI-B7-H3. A presente divulgação se refere a conjugados anticorpo-fármaco (ADCs) em que um ou mais agentes ativos são conjugados com um anticorpo anti-B7-H3 por meio de um conector. O conector pode compreender uma unidade que liga covalentemente agentes ativos ao anticorpo. A divulgação se refere ainda a anticorpos monoclonais e fragmentos de ligação ao antígeno, variantes, versões multiméricas ou biespecíficas dos mesmos especificamente que se ligam a B7-H3, bem como métodos de fabricação e uso desses anticorpos anti-B7-H3 e fragmentos de ligação ao antígeno dos mesmos em uma variedade de indicações terapêuticas, de diagnóstico e profiláticas.
BR112022026401A 2020-06-26 2021-06-25 Conjugados anticorpo-fármaco compreendendo anticorpos anti-b7-h3 BR112022026401A2 (pt)

Applications Claiming Priority (2)

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