CY1117036T1 - Ανθρωπινα αντισωματα που προσδενουν cxcr4 και χρησεις αυτων - Google Patents

Ανθρωπινα αντισωματα που προσδενουν cxcr4 και χρησεις αυτων

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Publication number
CY1117036T1
CY1117036T1 CY20151101127T CY151101127T CY1117036T1 CY 1117036 T1 CY1117036 T1 CY 1117036T1 CY 20151101127 T CY20151101127 T CY 20151101127T CY 151101127 T CY151101127 T CY 151101127T CY 1117036 T1 CY1117036 T1 CY 1117036T1
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CY
Cyprus
Prior art keywords
disclosure
antibodies
cxcr4
methods
human antibodies
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Application number
CY20151101127T
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English (en)
Inventor
Michelle Kuhne
Peter Brams
Dawn M Tanamachi
Alan Korman
Josephine M Cardarelli
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E. R. Squibb & Sons, L.L.C.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39402166&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1117036(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by E. R. Squibb & Sons, L.L.C. filed Critical E. R. Squibb & Sons, L.L.C.
Publication of CY1117036T1 publication Critical patent/CY1117036T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
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Abstract

Η παρούσα αποκάλυψη παρέχει απομονωμένα μονοκλωνικά αντισώματα τα οποία ειδικώς προσδένονται σε CXCR4 με υψηλή συγγένεια, ιδιαιτέρως ανθρώπινα μονοκλωνικά αντισώματα. Μόρια νουκλεϊνικού οξέος τα οποία κωδικοποιούν τα αντισώματα αυτής της αποκάλυψης, φορείς έκφρασης, κύτταρα ξενιστές και μέθοδοι για έκφραση των αντισωμάτων αυτής της αποκάλυψης παρέχονται επίσης. Προϊόντα ανοσοσύζευξης, διειδικά μόρια και φαρμακευτικές συνθέσεις που περιέχουν τα αντισώματα αυτής της αποκάλυψης παρέχονται επίσης. Η αποκάλυψη παρέχει επίσης μεθόδους για ανίχνευση CXCR4, καθώς και μεθόδους για τη θεραπευτική αγωγή διαφόρων καρκίνων, φλεγμονωδών διαταραχών και μόλυνσης HIV χρησιμοποιώντας ένα αντι-CXCR4 αντίσωμα αυτής της αποκάλυψης.
CY20151101127T 2006-10-02 2015-12-09 Ανθρωπινα αντισωματα που προσδενουν cxcr4 και χρησεις αυτων CY1117036T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82785106P 2006-10-02 2006-10-02
EP07867192.2A EP2066351B1 (en) 2006-10-02 2007-10-01 Human antibodies that bind cxcr4 and uses thereof

Publications (1)

Publication Number Publication Date
CY1117036T1 true CY1117036T1 (el) 2017-04-05

Family

ID=39402166

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20151101127T CY1117036T1 (el) 2006-10-02 2015-12-09 Ανθρωπινα αντισωματα που προσδενουν cxcr4 και χρησεις αυτων
CY20171100625T CY1118949T1 (el) 2006-10-02 2017-06-13 Ανθρωπινα αντισωματα που προσδενουν cxcr4 και χρησεις αυτων

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CY20171100625T CY1118949T1 (el) 2006-10-02 2017-06-13 Ανθρωπινα αντισωματα που προσδενουν cxcr4 και χρησεις αυτων

Country Status (30)

Country Link
US (3) US8450464B2 (el)
EP (2) EP2486941B1 (el)
JP (4) JP5417175B2 (el)
KR (3) KR20150065959A (el)
CN (2) CN101528259B (el)
AR (2) AR063086A1 (el)
AU (1) AU2007320024B2 (el)
BR (1) BRPI0718197A2 (el)
CA (1) CA2665239A1 (el)
CL (1) CL2007002835A1 (el)
CY (2) CY1117036T1 (el)
DK (2) DK2486941T3 (el)
EA (1) EA018836B1 (el)
ES (2) ES2625798T3 (el)
HK (1) HK1131904A1 (el)
HU (2) HUE033630T2 (el)
IL (1) IL197831A (el)
LT (1) LT2486941T (el)
ME (1) ME02269B (el)
MX (1) MX2009003306A (el)
NO (1) NO345287B1 (el)
NZ (1) NZ575924A (el)
PL (2) PL2486941T3 (el)
PT (2) PT2486941T (el)
RS (2) RS54424B1 (el)
SG (2) SG10201608268RA (el)
SI (2) SI2486941T1 (el)
TW (2) TWI592425B (el)
WO (1) WO2008060367A2 (el)
ZA (1) ZA200902256B (el)

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ES2553553T3 (es) 2015-12-10
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