SG11202011739SA - Modified self-immolating moieties for use in prodrugs and conjugates and methods of using and making - Google Patents
Modified self-immolating moieties for use in prodrugs and conjugates and methods of using and makingInfo
- Publication number
- SG11202011739SA SG11202011739SA SG11202011739SA SG11202011739SA SG11202011739SA SG 11202011739S A SG11202011739S A SG 11202011739SA SG 11202011739S A SG11202011739S A SG 11202011739SA SG 11202011739S A SG11202011739S A SG 11202011739SA SG 11202011739S A SG11202011739S A SG 11202011739SA
- Authority
- SG
- Singapore
- Prior art keywords
- prodrugs
- conjugates
- making
- methods
- modified self
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
- A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6865—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from skin, nerves or brain cancer cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862677307P | 2018-05-29 | 2018-05-29 | |
PCT/US2019/034114 WO2019231879A1 (en) | 2018-05-29 | 2019-05-28 | Modified self-immolating moieties for use in prodrugs and conjugates and methods of using and making |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202011739SA true SG11202011739SA (en) | 2020-12-30 |
Family
ID=66912963
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202011739SA SG11202011739SA (en) | 2018-05-29 | 2019-05-28 | Modified self-immolating moieties for use in prodrugs and conjugates and methods of using and making |
Country Status (13)
Country | Link |
---|---|
US (2) | US10898578B2 (en) |
EP (1) | EP3801629A1 (en) |
JP (2) | JP7458997B2 (en) |
KR (1) | KR20210015923A (en) |
CN (1) | CN112188902A (en) |
AU (1) | AU2019277094A1 (en) |
BR (1) | BR112020024022A2 (en) |
CA (1) | CA3101601A1 (en) |
EA (1) | EA202092747A1 (en) |
IL (1) | IL278938A (en) |
MX (1) | MX2020012674A (en) |
SG (1) | SG11202011739SA (en) |
WO (1) | WO2019231879A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
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SG11202011739SA (en) * | 2018-05-29 | 2020-12-30 | Bristol Myers Squibb Co | Modified self-immolating moieties for use in prodrugs and conjugates and methods of using and making |
CN113905758A (en) * | 2019-04-05 | 2022-01-07 | 大日本住友制药株式会社 | Water-soluble adjuvants and compositions containing the same |
JPWO2022255425A1 (en) * | 2021-06-01 | 2022-12-08 | ||
WO2023054714A1 (en) * | 2021-09-30 | 2023-04-06 | 味の素株式会社 | Regioselective conjugate of functional substance and antibody or salt of said conjugate, and antibody derivative and compound for use in production of said conjugate, or salt of said antibody derivative and compound |
CN116199740A (en) * | 2021-12-01 | 2023-06-02 | 上海生物制品研究所有限责任公司 | Antibody drug conjugates and uses thereof |
KR20230127918A (en) * | 2022-02-25 | 2023-09-01 | 앱티스 주식회사 | Novel antibody drug conjugate |
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US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
CN1371416B (en) | 1999-08-24 | 2012-10-10 | 梅达里克斯公司 | Human CTLA-4 antibodies and their uses |
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PE20050712A1 (en) | 2003-07-22 | 2005-11-02 | Schering Ag | RG1 ANTIBODIES |
DK1691837T3 (en) | 2003-12-10 | 2012-10-01 | Medarex Inc | IP-10 antibodies and their use |
WO2005082023A2 (en) | 2004-02-23 | 2005-09-09 | Genentech, Inc. | Heterocyclic self-immolative linkers and conjugates |
AU2005227326B2 (en) | 2004-03-24 | 2009-12-03 | Xencor, Inc. | Immunoglobulin variants outside the Fc region |
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JP5714212B2 (en) | 2005-12-08 | 2015-05-07 | メダレックス・リミテッド・ライアビリティ・カンパニーMedarex, L.L.C. | Human monoclonal antibody against O8E |
EA017491B1 (en) | 2005-12-08 | 2012-12-28 | Медарекс, Инк. | Human monoclonal antibodies to fucosyl-gm1 and methods for using anti-fucosyl-gm1 antibodies |
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JP2010500886A (en) | 2006-08-18 | 2010-01-14 | ノボ ノルディスク ヘルス ケア アーゲー | Transglutaminase variants with improved specificity |
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SG11202011739SA (en) * | 2018-05-29 | 2020-12-30 | Bristol Myers Squibb Co | Modified self-immolating moieties for use in prodrugs and conjugates and methods of using and making |
-
2019
- 2019-05-28 SG SG11202011739SA patent/SG11202011739SA/en unknown
- 2019-05-28 AU AU2019277094A patent/AU2019277094A1/en active Pending
- 2019-05-28 MX MX2020012674A patent/MX2020012674A/en unknown
- 2019-05-28 EA EA202092747A patent/EA202092747A1/en unknown
- 2019-05-28 CA CA3101601A patent/CA3101601A1/en active Pending
- 2019-05-28 CN CN201980035056.1A patent/CN112188902A/en active Pending
- 2019-05-28 BR BR112020024022-2A patent/BR112020024022A2/en unknown
- 2019-05-28 EP EP19731428.9A patent/EP3801629A1/en active Pending
- 2019-05-28 KR KR1020207037582A patent/KR20210015923A/en unknown
- 2019-05-28 JP JP2020566576A patent/JP7458997B2/en active Active
- 2019-05-28 WO PCT/US2019/034114 patent/WO2019231879A1/en unknown
- 2019-05-29 US US16/425,596 patent/US10898578B2/en active Active
-
2020
- 2020-11-24 IL IL278938A patent/IL278938A/en unknown
- 2020-12-18 US US17/126,555 patent/US11911483B2/en active Active
-
2024
- 2024-01-26 JP JP2024009895A patent/JP2024045327A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20210015923A (en) | 2021-02-10 |
JP2021525724A (en) | 2021-09-27 |
CN112188902A (en) | 2021-01-05 |
US11911483B2 (en) | 2024-02-27 |
US10898578B2 (en) | 2021-01-26 |
AU2019277094A1 (en) | 2021-01-21 |
US20210113706A1 (en) | 2021-04-22 |
WO2019231879A1 (en) | 2019-12-05 |
CA3101601A1 (en) | 2019-12-05 |
IL278938A (en) | 2021-01-31 |
US20190365915A1 (en) | 2019-12-05 |
BR112020024022A2 (en) | 2021-02-23 |
JP7458997B2 (en) | 2024-04-01 |
JP2024045327A (en) | 2024-04-02 |
EP3801629A1 (en) | 2021-04-14 |
MX2020012674A (en) | 2021-02-09 |
EA202092747A1 (en) | 2021-03-16 |
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