CY1117236T1 - Μονοκλωνικα αντισωματα εναντι γλυπικανης-3 - Google Patents
Μονοκλωνικα αντισωματα εναντι γλυπικανης-3Info
- Publication number
- CY1117236T1 CY1117236T1 CY20161100174T CY161100174T CY1117236T1 CY 1117236 T1 CY1117236 T1 CY 1117236T1 CY 20161100174 T CY20161100174 T CY 20161100174T CY 161100174 T CY161100174 T CY 161100174T CY 1117236 T1 CY1117236 T1 CY 1117236T1
- Authority
- CY
- Cyprus
- Prior art keywords
- antibodies
- glycican
- methods
- glypican
- antibodies against
- Prior art date
Links
- 102000010956 Glypican Human genes 0.000 title abstract 3
- 108050001154 Glypican Proteins 0.000 title abstract 3
- 108050007237 Glypican-3 Proteins 0.000 title abstract 3
- 239000013604 expression vector Substances 0.000 abstract 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 abstract 1
- 229940127121 immunoconjugate Drugs 0.000 abstract 1
- 208000014018 liver neoplasm Diseases 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/303—Liver or Pancreas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
Η παρούσα αποκάλυψη παρέχει απομονωθέντα μονοκλωνικά αντισώματα, ιδιαιτέρως ανθρώπινα μονοκλωνικά αντισώματα που συνδέονται ειδικώς προς Γλυπικάνη-3 με υψηλή συνάφεια. Επίσης παρέχονται μόρια νουκλεϊνικού οξέος που κωδικοποιούν αντισώματα Γλυπικάνης-3, φορείς έκφρασης, κύτταρα ξενιστές και μέθοδοι για έκφραση των αντισωμάτων Γλυπικάνης-3. Επίσης παρέχονται ανοσο-προϊόντα σύζευξης, διπλά-ειδικά μόρια και φαρμακευτικές συνθέσεις που περιλαμβάνουν τα αντισώματα Γλυπικάνης-3. Αποκαλύπτονται μέθοδοι για ανίχνευση Γλυπικάνης-3, καθώς επίσης μέθοδοι για θεραπεία διαφόρων καταστάσεων σχετικών με Γλυπικάνη-3, συμπεριλαμβανομένου ηπατοκυτταρικού καρκίνου.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95984507P | 2007-07-17 | 2007-07-17 | |
EP08796249.4A EP2178921B1 (en) | 2007-07-17 | 2008-07-17 | Monoclonal antibodies against glypican-3 |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1117236T1 true CY1117236T1 (el) | 2017-04-05 |
Family
ID=39874207
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20161100174T CY1117236T1 (el) | 2007-07-17 | 2016-03-01 | Μονοκλωνικα αντισωματα εναντι γλυπικανης-3 |
Country Status (18)
Country | Link |
---|---|
US (2) | US8680247B2 (el) |
EP (1) | EP2178921B1 (el) |
JP (2) | JP5868593B2 (el) |
KR (2) | KR101570252B1 (el) |
CN (1) | CN101815726B (el) |
AU (1) | AU2008275985B2 (el) |
CY (1) | CY1117236T1 (el) |
DK (1) | DK2178921T3 (el) |
ES (1) | ES2562790T3 (el) |
HR (1) | HRP20160270T1 (el) |
HU (1) | HUE028737T2 (el) |
ME (1) | ME02345B (el) |
MX (1) | MX2010000537A (el) |
PL (1) | PL2178921T3 (el) |
PT (1) | PT2178921E (el) |
RS (1) | RS54624B1 (el) |
SI (1) | SI2178921T1 (el) |
WO (1) | WO2009012394A1 (el) |
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AU2006232287B2 (en) | 2005-03-31 | 2011-10-06 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing polypeptides by regulating polypeptide association |
EP4342995A2 (en) | 2006-03-31 | 2024-03-27 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
SI2178921T1 (sl) * | 2007-07-17 | 2016-05-31 | E.R. Squibb & Sons, L.L.C. | Monoklonska protitelesa proti glipikan-3 |
EP3127921A1 (en) | 2007-09-26 | 2017-02-08 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substition in cdr |
AU2008305851B2 (en) * | 2007-09-28 | 2014-12-18 | Chugai Seiyaku Kabushiki Kaisha | Anti-glypican-3 antibody having improved kinetics in plasma |
CL2009000647A1 (es) * | 2008-04-04 | 2010-06-04 | Chugai Pharmaceutical Co Ltd | Composicion farmaceutica para tratar o prevenir cancer hepatico que comprende una combinacion de un agente quimioterapeutico y un anticuerpo anti-glipicano 3; agente para atenuar un efecto secundario que comprende dicho anticuerpo; metodo para tratar o prevenir un cancer hepatico de un sujeto. |
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US9260492B2 (en) | 2010-11-15 | 2016-02-16 | Pieris Ag | Muteins of human lipocalin 2 with affinity for glypican-3 (GPC-3) |
US11066483B2 (en) | 2010-11-30 | 2021-07-20 | Chugai Seiyaku Kabushiki Kaisha | Cytotoxicity-inducing therapeutic agent |
EP2660328A4 (en) * | 2010-12-28 | 2016-07-13 | Chugai Pharmaceutical Co Ltd | ANIMAL CELL CULTURE METHOD |
EP2998320B1 (en) | 2011-04-19 | 2018-07-18 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Human monoclonal antibodies specific for glypican-3 and use thereof |
US8852599B2 (en) | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
WO2013070468A1 (en) * | 2011-11-08 | 2013-05-16 | The Trustees Of The University Of Pennsylvania | Glypican-3-specific antibody and uses thereof |
WO2013181543A1 (en) * | 2012-06-01 | 2013-12-05 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | High-affinity monoclonal antibodies to glypican-3 and use thereof |
CN103833852A (zh) * | 2012-11-23 | 2014-06-04 | 上海市肿瘤研究所 | 针对磷脂酰肌醇蛋白多糖-3和t细胞抗原的双特异性抗体 |
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EA201690388A1 (ru) | 2013-08-14 | 2016-07-29 | Уильям Марш Райс Юниверсити | Новые производные унциаламицина, способы их синтеза и их применение в качестве противоопухолевых агентов |
JP6534615B2 (ja) | 2013-09-27 | 2019-06-26 | 中外製薬株式会社 | ポリペプチド異種多量体の製造方法 |
WO2016036973A1 (en) | 2014-09-04 | 2016-03-10 | The Trustees Of The University Of Pennsylvania | Glypican-3 antibody and uses thereof |
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CN107922951B (zh) * | 2015-06-24 | 2022-01-14 | 学校法人庆应义塾 | 抗磷脂酰肌醇蛋白聚糖-1-免疫抗原受体 |
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2008
- 2008-07-17 SI SI200831584A patent/SI2178921T1/sl unknown
- 2008-07-17 PL PL08796249T patent/PL2178921T3/pl unknown
- 2008-07-17 MX MX2010000537A patent/MX2010000537A/es active IP Right Grant
- 2008-07-17 PT PT87962494T patent/PT2178921E/pt unknown
- 2008-07-17 CN CN2008801031669A patent/CN101815726B/zh not_active Expired - Fee Related
- 2008-07-17 JP JP2010517161A patent/JP5868593B2/ja not_active Expired - Fee Related
- 2008-07-17 WO PCT/US2008/070344 patent/WO2009012394A1/en active Application Filing
- 2008-07-17 ME MEP-2016-86A patent/ME02345B/me unknown
- 2008-07-17 HU HUE08796249A patent/HUE028737T2/en unknown
- 2008-07-17 DK DK08796249.4T patent/DK2178921T3/en active
- 2008-07-17 US US12/668,965 patent/US8680247B2/en active Active
- 2008-07-17 KR KR1020107003345A patent/KR101570252B1/ko active IP Right Grant
- 2008-07-17 RS RS20160157A patent/RS54624B1/en unknown
- 2008-07-17 AU AU2008275985A patent/AU2008275985B2/en not_active Ceased
- 2008-07-17 EP EP08796249.4A patent/EP2178921B1/en active Active
- 2008-07-17 ES ES08796249.4T patent/ES2562790T3/es active Active
- 2008-07-17 KR KR1020157007446A patent/KR101527342B1/ko active IP Right Grant
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2014
- 2014-02-10 US US14/176,790 patent/US9217033B2/en active Active
- 2014-07-03 JP JP2014137921A patent/JP2014236734A/ja active Pending
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2016
- 2016-03-01 CY CY20161100174T patent/CY1117236T1/el unknown
- 2016-03-15 HR HRP20160270TT patent/HRP20160270T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
ES2562790T3 (es) | 2016-03-08 |
US20140186892A1 (en) | 2014-07-03 |
JP2010533498A (ja) | 2010-10-28 |
MX2010000537A (es) | 2010-03-25 |
US9217033B2 (en) | 2015-12-22 |
US8680247B2 (en) | 2014-03-25 |
AU2008275985B2 (en) | 2013-09-19 |
AU2008275985A1 (en) | 2009-01-22 |
SI2178921T1 (sl) | 2016-05-31 |
RS54624B1 (en) | 2016-08-31 |
KR20150038732A (ko) | 2015-04-08 |
WO2009012394A1 (en) | 2009-01-22 |
EP2178921B1 (en) | 2016-01-06 |
EP2178921A1 (en) | 2010-04-28 |
DK2178921T3 (en) | 2016-04-04 |
US20100209432A1 (en) | 2010-08-19 |
PL2178921T3 (pl) | 2016-06-30 |
KR101570252B1 (ko) | 2015-11-19 |
JP5868593B2 (ja) | 2016-02-24 |
CN101815726B (zh) | 2013-04-03 |
ME02345B (me) | 2016-08-31 |
PT2178921E (pt) | 2016-03-23 |
KR101527342B1 (ko) | 2015-06-09 |
KR20100056467A (ko) | 2010-05-27 |
HRP20160270T1 (hr) | 2016-05-06 |
CN101815726A (zh) | 2010-08-25 |
HUE028737T2 (en) | 2017-01-30 |
JP2014236734A (ja) | 2014-12-18 |
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