WO2006116192A3 - Irta-1 antibodies and their uses - Google Patents

Irta-1 antibodies and their uses Download PDF

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Publication number
WO2006116192A3
WO2006116192A3 PCT/US2006/015256 US2006015256W WO2006116192A3 WO 2006116192 A3 WO2006116192 A3 WO 2006116192A3 US 2006015256 W US2006015256 W US 2006015256W WO 2006116192 A3 WO2006116192 A3 WO 2006116192A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibodies
irta
methods
monoclonal antibodies
immunoconjugates
Prior art date
Application number
PCT/US2006/015256
Other languages
French (fr)
Other versions
WO2006116192A2 (en
Inventor
Robert Graziano
David J King
Thomas D Kempe
Mohan Srinivasan
Josephine M Cardarelli
Morgan Truitt
Jie Liu
Original Assignee
Medarex Inc
Robert Graziano
David J King
Thomas D Kempe
Mohan Srinivasan
Josephine M Cardarelli
Morgan Truitt
Jie Liu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medarex Inc, Robert Graziano, David J King, Thomas D Kempe, Mohan Srinivasan, Josephine M Cardarelli, Morgan Truitt, Jie Liu filed Critical Medarex Inc
Publication of WO2006116192A2 publication Critical patent/WO2006116192A2/en
Publication of WO2006116192A3 publication Critical patent/WO2006116192A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to IRTA-I with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting IRTA-I, as well as methods for treating various B cell malignancies, including Multiple Myeloma and diffuse large B cell lymphomas.
PCT/US2006/015256 2005-04-21 2006-04-20 Irta-1 antibodies and their uses WO2006116192A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67363605P 2005-04-21 2005-04-21
US60/673,636 2005-04-21

Publications (2)

Publication Number Publication Date
WO2006116192A2 WO2006116192A2 (en) 2006-11-02
WO2006116192A3 true WO2006116192A3 (en) 2007-05-24

Family

ID=37215332

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/015256 WO2006116192A2 (en) 2005-04-21 2006-04-20 Irta-1 antibodies and their uses

Country Status (1)

Country Link
WO (1) WO2006116192A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL199534A (en) 2007-01-05 2013-01-31 Univ Zuerich Isolated human antibody which is capable of selectively recognizing a neoepitope of a disorder-associated protein, a polynucleotide encoding the antibody, a vector comprising the polynucleotide, a host cell comprising the polynucleotide or the vector, a composition comprising the antibody and methods and uses associated therewith
CN102317316B (en) 2008-12-19 2014-08-13 帕尼玛制药股份公司 Human anti-alpha-synuclein autoantibodies
BR112013033258B1 (en) 2011-06-23 2022-09-20 University Of Zurich ISOLATED ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF WHICH BINDS ALPHASINUCLEIN, COMPOSITION AND ITS USES
MA41115A (en) 2014-12-02 2017-10-10 Biogen Int Neuroscience Gmbh ALZHEIMER'S DISEASE TREATMENT PROCESS
IL272773B2 (en) 2017-08-22 2024-06-01 Biogen Ma Inc Pharmaceutical compositions containing anti-beta amyloid antibodies
AU2020243076A1 (en) * 2019-03-20 2021-10-14 Centre National De La Recherche Scientifique - Cnrs - Antibodies having specificity for BTN2 and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030078396A1 (en) * 2000-03-01 2003-04-24 Corixa Corporation Compositions and methods for the detection, diagnosis and therapy of hematological malignancies

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030078396A1 (en) * 2000-03-01 2003-04-24 Corixa Corporation Compositions and methods for the detection, diagnosis and therapy of hematological malignancies

Also Published As

Publication number Publication date
WO2006116192A2 (en) 2006-11-02

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