CY1113958T1 - HUMAN MONOCLONIC ANTIBODIES IN FUKOZYL-GM1 AND METHODS FOR USE ANTI-FUKOZYL-GM1 - Google Patents

HUMAN MONOCLONIC ANTIBODIES IN FUKOZYL-GM1 AND METHODS FOR USE ANTI-FUKOZYL-GM1

Info

Publication number
CY1113958T1
CY1113958T1 CY20121100886T CY121100886T CY1113958T1 CY 1113958 T1 CY1113958 T1 CY 1113958T1 CY 20121100886 T CY20121100886 T CY 20121100886T CY 121100886 T CY121100886 T CY 121100886T CY 1113958 T1 CY1113958 T1 CY 1113958T1
Authority
CY
Cyprus
Prior art keywords
fukozyl
antibodies
methods
disclosure
human
Prior art date
Application number
CY20121100886T
Other languages
Greek (el)
Inventor
Cynthia A Vistica
Eric H Holmes
Peter Brams
Alison Witte
Josephine M Cardarelli
Original Assignee
Medarex, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP06840172A external-priority patent/EP1960434B1/en
Application filed by Medarex, Inc. filed Critical Medarex, Inc.
Publication of CY1113958T1 publication Critical patent/CY1113958T1/en

Links

Abstract

Η παρούσα αποκάλυψη παρέχει απομονωμένα μονοκλωνικά αντισώματα, ιδιαιτέρως ανθρώπινα μονοκλωνικά αντισώματα τα οποία προσδένονται ειδικώς σε Φουκοζυλ-GM1 με υψηλή συγγένεια. Μόρια νουκλεϊνικών οξέων που κωδικοποιούν τα αντισώματα αυτής της αποκάλυψης, φορείς έκφρασης, κύτταρα ξενιστές και μέθοδοι για την έκφραση των αντισωμάτων αυτής της αποκάλυψης παρέχονται επίσης. Προϊόντα ανοσοσύζευξης, διειδικά μόρια και φαρμακευτικές συνθέσεις που περιλαμβάνουν τα αντισώματα αυτής της αποκάλυψης παρέχονται επίσης. Η αποκάλυψη αυτή παρέχει επίσης μεθόδους για την ανίχνευση Φουκοζυλ- GM1, καθώς επίσης μεθόδους για τη θεραπευτική αγωγή διαφόρων ασθενειών, που περιλαμβάνουν καρκίνο, χρησιμοποιώντας αντισώματα αντι-Φουκοζυλ- GM1.The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that bind specifically to Fucosyl-GM1 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for the detection of Fukozyl-GM1, as well as methods for the treatment of various diseases, including cancer, using anti-Fukozyl-GM1 antibodies.

CY20121100886T 2005-12-08 2012-09-28 HUMAN MONOCLONIC ANTIBODIES IN FUKOZYL-GM1 AND METHODS FOR USE ANTI-FUKOZYL-GM1 CY1113958T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74891505A 2005-12-08 2005-12-08
EP06840172A EP1960434B1 (en) 2005-12-08 2006-12-08 Human monoclonal antibodies to fucosyl-gm1 and methods for using anti-fucosyl-gm1

Publications (1)

Publication Number Publication Date
CY1113958T1 true CY1113958T1 (en) 2016-07-27

Family

ID=58448980

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100886T CY1113958T1 (en) 2005-12-08 2012-09-28 HUMAN MONOCLONIC ANTIBODIES IN FUKOZYL-GM1 AND METHODS FOR USE ANTI-FUKOZYL-GM1

Country Status (1)

Country Link
CY (1) CY1113958T1 (en)

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