CY1116843T1 - HUMAN MONOCLONE ANTIBODIES TO CONNECTOR 1 PROGRAMMED DEATH (PD-L1) - Google Patents

HUMAN MONOCLONE ANTIBODIES TO CONNECTOR 1 PROGRAMMED DEATH (PD-L1)

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Publication number
CY1116843T1
CY1116843T1 CY20151100952T CY151100952T CY1116843T1 CY 1116843 T1 CY1116843 T1 CY 1116843T1 CY 20151100952 T CY20151100952 T CY 20151100952T CY 151100952 T CY151100952 T CY 151100952T CY 1116843 T1 CY1116843 T1 CY 1116843T1
Authority
CY
Cyprus
Prior art keywords
antibodies
methods
connector
human
programmed death
Prior art date
Application number
CY20151100952T
Other languages
Greek (el)
Inventor
Alan J Korman
Mark J Selby
Changyu Wang
Mohan Srinivasan
David B Passmore
Haichun Huang
Haibin Chen
Original Assignee
E. R. Squibb & Sons, L.L.C.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP06786260.7A external-priority patent/EP1907424B1/en
Application filed by E. R. Squibb & Sons, L.L.C. filed Critical E. R. Squibb & Sons, L.L.C.
Publication of CY1116843T1 publication Critical patent/CY1116843T1/en

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  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Η παρούσα αποκάλυψη παρέχει απομονωθέντα μονοκλωνικά αντισώματα, ιδιαιτέρως ανθρώπινα μονοκλωνικά αντισώματα που ειδικώς συνδέονται προς PD-L1 με υψηλή συνάφεια. Επίσης παρέχονται μόρια νουκλεϊνικού οξέος που κωδικοποιούν τα αντισώματα αυτής της αποκάλυψης, φορείς έκφρασης, κύτταρα ξενιστές και μέθοδοι για έκφραση των αντισωμάτων της παρούσας περιγραφής. Επίσης παρέχονται ανοσοπροϊόντα σύζευξης, διπλά-ειδικά μόρια και φαρμακευτικές συνθέσεις που περιλαμβάνουν τα αντισώματα της εφεύρεσης. Η αποκάλυψη επίσης παρέχει μεθόδους για ανίχνευση PD-L1, καθώς επίσης μεθόδους για θεραπεία διαφόρων ασθενειών, που συμπεριλαμβάνουν καρκίνο και μολυσματώδεις ασθένειες, χρησιμοποιώντας αντι-PD-L1 αντισώματα.The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to PD-L1 with high affinity. Also provided are nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells, and methods for expressing the antibodies herein. Also provided are immunoconjugates, double-specific molecules, and pharmaceutical compositions comprising the antibodies of the invention. The disclosure also provides methods for detecting PD-L1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-L1 antibodies.

CY20151100952T 2005-07-01 2015-10-26 HUMAN MONOCLONE ANTIBODIES TO CONNECTOR 1 PROGRAMMED DEATH (PD-L1) CY1116843T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69642605A 2005-07-01 2005-07-01
EP06786260.7A EP1907424B1 (en) 2005-07-01 2006-06-30 Human monoclonal antibodies to programmed death ligand 1 (pd-l1)

Publications (1)

Publication Number Publication Date
CY1116843T1 true CY1116843T1 (en) 2017-03-15

Family

ID=58459811

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20151100952T CY1116843T1 (en) 2005-07-01 2015-10-26 HUMAN MONOCLONE ANTIBODIES TO CONNECTOR 1 PROGRAMMED DEATH (PD-L1)

Country Status (1)

Country Link
CY (1) CY1116843T1 (en)

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