CY1114151T1 - HUMAN monoclonal antibodies for the movement of Tyrosine Protein 7 (RTK7) and their use - Google Patents

HUMAN monoclonal antibodies for the movement of Tyrosine Protein 7 (RTK7) and their use

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Publication number
CY1114151T1
CY1114151T1 CY20131100598T CY131100598T CY1114151T1 CY 1114151 T1 CY1114151 T1 CY 1114151T1 CY 20131100598 T CY20131100598 T CY 20131100598T CY 131100598 T CY131100598 T CY 131100598T CY 1114151 T1 CY1114151 T1 CY 1114151T1
Authority
CY
Cyprus
Prior art keywords
antibodies
monoclonal antibodies
human monoclonal
ptk7
rtk7
Prior art date
Application number
CY20131100598T
Other languages
Greek (el)
Inventor
Li-Sheng Lu
Jonathan Alexander Terrett
Chin Pan
Original Assignee
Medarex, L.L.C.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP06848508.5A external-priority patent/EP1957539B1/en
Application filed by Medarex, L.L.C. filed Critical Medarex, L.L.C.
Publication of CY1114151T1 publication Critical patent/CY1114151T1/en

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Abstract

Η παρούσα εφεύρεση παρέχει απομονωμένα μονοκλωνικά αντισώματα, ειδικότερα δε ανθρώπινα μονοκλωνικά αντισώματα που δεσμεύονται συγκεκριμένα στην ΡΤΚ7 με υψηλή συγγένεια. Μόρια πυρηνικών οξέων εγκωδικεύοντας τα αντισώματα της εφεύρεσης, ανύσματα έκφρασης, κύτταρα ξενιστών και μέθοδοι για την έκφραση των αντισωμάτων της εφεύρεσης παρέχονται επίσης. Ανοσοσυζεύγματα, δι-ειδικά μόρια και φαρμακευτικές συνθέσεις περιλαμβάνοντας τα αντισώματα της εφεύρεσης παρέχονται επίσης. Η εφεύρεση παρέχει επίσης μεθόδους και για την ανίχνευση της ΡΤΚ7, ως επίσης και μεθόδους για την αγωγή διαφόρων παθήσεων συμπεριλαμβάνοντας καρκίνο και λοιμώδεις παθήσεις, χρησιμοποιώντας αντισώματα αντι-ΡΤΚ7.The present invention provides isolated monoclonal antibodies, in particular human monoclonal antibodies that specifically bind to high affinity PTK7. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases including cancer and infectious diseases, using anti-PTK7 antibodies.

CY20131100598T 2005-12-08 2013-07-15 HUMAN monoclonal antibodies for the movement of Tyrosine Protein 7 (RTK7) and their use CY1114151T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74837305A 2005-12-08 2005-12-08
EP06848508.5A EP1957539B1 (en) 2005-12-08 2006-12-08 Human monoclonal antibodies to protein tyrosine kinase 7 (ptk7) and their use

Publications (1)

Publication Number Publication Date
CY1114151T1 true CY1114151T1 (en) 2016-08-31

Family

ID=58436313

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131100598T CY1114151T1 (en) 2005-12-08 2013-07-15 HUMAN monoclonal antibodies for the movement of Tyrosine Protein 7 (RTK7) and their use

Country Status (1)

Country Link
CY (1) CY1114151T1 (en)

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