MX371455B - Anticuerpos anti-cxcr4 y conjugados de anticuerpo y farmaco. - Google Patents

Anticuerpos anti-cxcr4 y conjugados de anticuerpo y farmaco.

Info

Publication number
MX371455B
MX371455B MX2016001485A MX2016001485A MX371455B MX 371455 B MX371455 B MX 371455B MX 2016001485 A MX2016001485 A MX 2016001485A MX 2016001485 A MX2016001485 A MX 2016001485A MX 371455 B MX371455 B MX 371455B
Authority
MX
Mexico
Prior art keywords
antibody
antibodies
drug conjugates
cxcr4
invention further
Prior art date
Application number
MX2016001485A
Other languages
English (en)
Other versions
MX2016001485A (es
Inventor
Hsien Ho Wei-
Hui Liu Shu-
Mercer Pernasetti Flavia
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX2016001485A publication Critical patent/MX2016001485A/es
Publication of MX371455B publication Critical patent/MX371455B/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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Abstract

La presente invención se refiere a anticuerpos y moléculas relacionadas que se fijan al receptor de quimiocina 4 (CXCR4). También conjugados de anticuerpo y fármaco que comprenden tales anticuerpos, ácidos nucleicos que codifican el anticuerpo y métodos para obtener tales anticuerpos. También métodos terapéuticos para usar estos anticuerpos y conjugados de anticuerpo CXCR4 y fármaco para el tratamiento de un trastorno asociado a la función o expresión de CXCR4 (por ejemplo, cáncer), tal como cáncer de colon, RCC, cáncer de esófago, cáncer gástrico, cáncer de cabeza y cuello, cáncer de pulmón, cáncer de ovarios, cáncer de páncreas y cáncer hematológico.
MX2016001485A 2013-08-02 2014-07-28 Anticuerpos anti-cxcr4 y conjugados de anticuerpo y farmaco. MX371455B (es)

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