MX2019005934A - Compuestos de benzodiazolio como inhibidores del canal de sodio epitelial (enac). - Google Patents
Compuestos de benzodiazolio como inhibidores del canal de sodio epitelial (enac).Info
- Publication number
- MX2019005934A MX2019005934A MX2019005934A MX2019005934A MX2019005934A MX 2019005934 A MX2019005934 A MX 2019005934A MX 2019005934 A MX2019005934 A MX 2019005934A MX 2019005934 A MX2019005934 A MX 2019005934A MX 2019005934 A MX2019005934 A MX 2019005934A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- benzodiazolium
- enac inhibitors
- conditions
- enac
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Compuestos de formula general (I)(ver formula) (I) en donde R1, R2, R3, R4, R5 y X son como se definen en la presente son inhibidores del canal de sodio epitelial (ENaC) y son utiles para el tratamiento o prevención de enfermedades y condiciones respiratorias, condiciones de la piel y condiciones oculares.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1619694.1A GB201619694D0 (en) | 2016-11-22 | 2016-11-22 | Compounds |
PCT/GB2017/053499 WO2018096325A1 (en) | 2016-11-22 | 2017-11-22 | Benzodiazolium compounds as enac inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019005934A true MX2019005934A (es) | 2019-11-12 |
Family
ID=57993838
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019005934A MX2019005934A (es) | 2016-11-22 | 2017-11-22 | Compuestos de benzodiazolio como inhibidores del canal de sodio epitelial (enac). |
Country Status (21)
Country | Link |
---|---|
US (3) | US10941149B2 (es) |
EP (1) | EP3544981B1 (es) |
JP (1) | JP6980014B2 (es) |
KR (1) | KR102517273B1 (es) |
CN (1) | CN110214141B (es) |
AU (1) | AU2017364308B2 (es) |
BR (1) | BR112019009864A2 (es) |
CA (1) | CA3043132A1 (es) |
DK (1) | DK3544981T3 (es) |
EA (1) | EA039607B1 (es) |
ES (1) | ES2890226T3 (es) |
GB (1) | GB201619694D0 (es) |
HU (1) | HUE055692T2 (es) |
IL (1) | IL266745B (es) |
MA (1) | MA46878A (es) |
MX (1) | MX2019005934A (es) |
PL (1) | PL3544981T3 (es) |
PT (1) | PT3544981T (es) |
TW (1) | TWI756305B (es) |
WO (1) | WO2018096325A1 (es) |
ZA (1) | ZA201902710B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201610854D0 (en) | 2016-06-21 | 2016-08-03 | Entpr Therapeutics Ltd | Compounds |
GB201619694D0 (en) | 2016-11-22 | 2017-01-04 | Entpr Therapeutics Ltd | Compounds |
GB201717051D0 (en) | 2017-10-17 | 2017-11-29 | Enterprise Therapeutics Ltd | Compounds |
GB201801355D0 (en) | 2018-01-26 | 2018-03-14 | Enterprise Therapeutics Ltd | Compounds |
GB201808093D0 (en) * | 2018-05-18 | 2018-07-04 | Enterprise Therapeutics Ltd | Compounds |
MA56186A (fr) | 2019-06-12 | 2022-04-20 | Tmem16A Ltd | Composés pour le traitement d'une maladie respiratoire |
GB201908453D0 (en) | 2019-06-12 | 2019-07-24 | Enterprise Therapeutics Ltd | Compounds for treating respiratory disease |
GB201910608D0 (en) * | 2019-07-24 | 2019-09-04 | Enterprise Therapeutics Ltd | Compounds |
TW202237090A (zh) | 2020-12-11 | 2022-10-01 | 英商Tmem16A有限公司 | 治療呼吸道疾病之化合物 |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6858614B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenolic guanidine sodium channel blockers |
US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
US6903105B2 (en) | 2003-02-19 | 2005-06-07 | Parion Sciences, Inc. | Sodium channel blockers |
AU2004266704B2 (en) | 2003-08-18 | 2012-02-23 | Parion Sciences, Inc. | Capped pyrazinoylguanidine sodium channel blockers |
US7317013B2 (en) | 2003-08-18 | 2008-01-08 | Parion Sciences, Inc. | Cyclic pyrazinoylguanidine sodium channel blockers |
US7375107B2 (en) | 2003-08-18 | 2008-05-20 | Parion Sciences, Inc. | Alaphatic pyrazinoylguanidine sodium channel blockers |
US20050090505A1 (en) | 2003-08-18 | 2005-04-28 | Johnson Michael R. | Methods of reducing risk of infection from pathogens |
US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
RU2006118312A (ru) * | 2003-10-28 | 2007-12-10 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Бензимидазолы, полезные в качестве модуляторов ионных каналов |
US7399766B2 (en) | 2004-08-18 | 2008-07-15 | Parion Sciences, Inc. | Soluble amide & ester pyrazinoylguanidine sodium channel blockers |
JP5066514B2 (ja) * | 2005-03-14 | 2012-11-07 | ハイ ポイント ファーマシューティカルズ,エルエルシー | ベンズアゾール誘導体、組成物及びβ−セクレターゼ阻害剤としての使用方法 |
US7807834B2 (en) | 2005-08-03 | 2010-10-05 | Parion Sciences, Inc. | Capped pyrazinoylguanidine sodium channel blockers |
GB0526240D0 (en) | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
GB0526244D0 (en) | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
US8288391B2 (en) | 2007-04-03 | 2012-10-16 | Parion Sciences, Inc. | Pyrazinoylguanidine compounds for use as taste modulators |
ES2361595T3 (es) | 2007-05-07 | 2011-06-20 | Novartis Ag | Compuestos orgánicos. |
WO2009019506A1 (en) | 2007-08-03 | 2009-02-12 | Astrazeneca Ab | Heterocyclyc sulfonamides having edg-1 antagonistic activity |
MX2010006421A (es) | 2007-12-10 | 2010-06-25 | Novartis Ag | Compuestos organicos. |
AU2009246799B2 (en) | 2008-02-26 | 2014-02-27 | Parion Sciences, Inc. | Poly aromatic pyrazinoylguanidine sodium channel blockers |
JP2011520831A (ja) | 2008-05-13 | 2011-07-21 | ノバルティス アーゲー | 3,5−ジアミノ−6−クロロ−ピラジン−2−カルボン酸誘導体および気道疾患処置用上皮性ナトリウムチャネルブロッカーとしてのその使用 |
BRPI0915018A2 (pt) | 2008-06-10 | 2015-10-27 | Novartis Ag | compostos orgânicos |
WO2011028740A1 (en) | 2009-09-03 | 2011-03-10 | Glaxo Group Limited | ENaC BLOCKERS |
WO2011079087A1 (en) * | 2009-12-23 | 2011-06-30 | Glaxo Group Limited | Enac blockers |
US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
TW201204353A (en) * | 2010-06-08 | 2012-02-01 | Vertex Pharma | Formulations of (R)-1-(2,2-difluorobenzo[D][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide |
US8372845B2 (en) | 2010-09-17 | 2013-02-12 | Novartis Ag | Pyrazine derivatives as enac blockers |
AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
US8759349B2 (en) | 2011-11-02 | 2014-06-24 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof |
US8859559B2 (en) | 2011-12-20 | 2014-10-14 | Boehringer Ingelheim International Gmbh | Substituted pyrazines and their use in the treatment of disease |
EP2855435B1 (en) | 2012-05-29 | 2018-04-11 | Parion Sciences, Inc. | Dendrimer like amino amides possessing sodium channel blocker activity for the treatment of dry eye and other mucosal diseases |
JP6072920B2 (ja) | 2012-09-24 | 2017-02-01 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 複素環化合物、前記化合物を含む薬物、これらの使用及びこれらの調製方法 |
ES2674665T3 (es) | 2012-12-17 | 2018-07-03 | Parion Sciences, Inc. | Compuestos de 3,5-diamino-6-cloro-N-(N-(4-fenilbutilo)carbamimidoilo)-pirazina-2-carboxamida |
CA2895512C (en) | 2012-12-17 | 2021-10-19 | Parion Sciences, Inc. | Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration |
MX2015007797A (es) | 2012-12-17 | 2015-10-05 | Parion Sciences Inc | Compuestos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil) carbamimidoil) pirazin-2-carboxamida. |
EP2991981B1 (en) | 2013-04-30 | 2017-03-01 | Boehringer Ingelheim International GmbH | Diaminopyrazine compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof |
WO2015003083A1 (en) | 2013-07-02 | 2015-01-08 | The California Institute For Biomedical Research | Compounds for treatment of cystic fibrosis |
JP6449870B2 (ja) | 2013-07-08 | 2019-01-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 肺および気道の疾患を処置するための上皮性ナトリウムチャネルの阻害剤としてのアミロライド型化合物 |
WO2015007517A1 (en) | 2013-07-15 | 2015-01-22 | Boehringer Ingelheim International Gmbh | Novel tetra- and pentasubstituted benzimidazolium compounds |
EP3022198B1 (en) | 2013-07-15 | 2019-09-11 | Boehringer Ingelheim International GmbH | Novel 5-substituted benzimidazolium compounds |
WO2015007519A1 (en) | 2013-07-15 | 2015-01-22 | Boehringer Ingelheim International Gmbh | Novel benzimidazolium compounds |
WO2015018754A1 (en) | 2013-08-08 | 2015-02-12 | Boehringer Ingelheim International Gmbh | Novel pyrazine amide compounds |
WO2016113167A1 (en) * | 2015-01-12 | 2016-07-21 | Boehringer Ingelheim International Gmbh | Substituted benzimidazolium compounds useful in the treatment of respiratory diseases |
US9981954B2 (en) | 2015-01-12 | 2018-05-29 | Boehringer Ingelheim International Gmbh | 2-(pyrazin-2-ylcarbonylaminomethyl) benzimidazolium compounds as epithelial sodium channel inhibitors |
JP6667537B2 (ja) | 2015-01-12 | 2020-03-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 呼吸器系疾患の治療に有用な四置換及び五置換ベンズイミダゾリウム化合物 |
US9932324B2 (en) | 2015-01-12 | 2018-04-03 | Boehringer Ingelheim International Gmbh | Substituted benzimidazolium compounds useful in the treatment of respiratory diseases |
DK3298022T3 (da) | 2015-08-20 | 2019-08-26 | Boehringer Ingelheim Int | Nye annelerede phenoxyacetamider |
EP3337483B1 (en) | 2015-08-20 | 2019-10-09 | Boehringer Ingelheim International GmbH | Novel annelated benzamides |
GB201610854D0 (en) * | 2016-06-21 | 2016-08-03 | Entpr Therapeutics Ltd | Compounds |
GB201619694D0 (en) * | 2016-11-22 | 2017-01-04 | Entpr Therapeutics Ltd | Compounds |
-
2016
- 2016-11-22 GB GBGB1619694.1A patent/GB201619694D0/en not_active Ceased
-
2017
- 2017-11-22 DK DK17807900.0T patent/DK3544981T3/da active
- 2017-11-22 TW TW106140573A patent/TWI756305B/zh active
- 2017-11-22 AU AU2017364308A patent/AU2017364308B2/en active Active
- 2017-11-22 JP JP2019527365A patent/JP6980014B2/ja active Active
- 2017-11-22 PL PL17807900T patent/PL3544981T3/pl unknown
- 2017-11-22 CN CN201780084165.3A patent/CN110214141B/zh active Active
- 2017-11-22 US US16/462,794 patent/US10941149B2/en active Active
- 2017-11-22 EA EA201991253A patent/EA039607B1/ru unknown
- 2017-11-22 MX MX2019005934A patent/MX2019005934A/es unknown
- 2017-11-22 ES ES17807900T patent/ES2890226T3/es active Active
- 2017-11-22 HU HUE17807900A patent/HUE055692T2/hu unknown
- 2017-11-22 BR BR112019009864A patent/BR112019009864A2/pt active Search and Examination
- 2017-11-22 CA CA3043132A patent/CA3043132A1/en active Pending
- 2017-11-22 KR KR1020197016141A patent/KR102517273B1/ko active IP Right Grant
- 2017-11-22 WO PCT/GB2017/053499 patent/WO2018096325A1/en unknown
- 2017-11-22 EP EP17807900.0A patent/EP3544981B1/en active Active
- 2017-11-22 MA MA046878A patent/MA46878A/fr unknown
- 2017-11-22 PT PT178079000T patent/PT3544981T/pt unknown
-
2019
- 2019-04-30 ZA ZA2019/02710A patent/ZA201902710B/en unknown
- 2019-05-20 IL IL266745A patent/IL266745B/en unknown
-
2020
- 2020-11-24 US US17/103,559 patent/US11739094B2/en active Active
-
2023
- 2023-06-30 US US18/345,840 patent/US20240067653A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
DK3544981T3 (da) | 2021-09-20 |
KR20190084076A (ko) | 2019-07-15 |
PL3544981T3 (pl) | 2021-12-20 |
ZA201902710B (en) | 2021-10-27 |
CN110214141A (zh) | 2019-09-06 |
TWI756305B (zh) | 2022-03-01 |
IL266745B (en) | 2021-12-01 |
US10941149B2 (en) | 2021-03-09 |
MA46878A (fr) | 2019-10-02 |
US20240067653A1 (en) | 2024-02-29 |
EP3544981A1 (en) | 2019-10-02 |
JP2019535747A (ja) | 2019-12-12 |
TW201833111A (zh) | 2018-09-16 |
US20210147432A1 (en) | 2021-05-20 |
HUE055692T2 (hu) | 2021-12-28 |
WO2018096325A1 (en) | 2018-05-31 |
EP3544981B1 (en) | 2021-06-23 |
US20190315757A1 (en) | 2019-10-17 |
KR102517273B1 (ko) | 2023-04-03 |
US11739094B2 (en) | 2023-08-29 |
JP6980014B2 (ja) | 2021-12-15 |
IL266745A (en) | 2019-07-31 |
EA201991253A1 (ru) | 2019-11-29 |
CN110214141B (zh) | 2022-05-31 |
AU2017364308B2 (en) | 2021-03-11 |
GB201619694D0 (en) | 2017-01-04 |
EA039607B1 (ru) | 2022-02-16 |
AU2017364308A1 (en) | 2019-05-23 |
BR112019009864A2 (pt) | 2019-08-27 |
PT3544981T (pt) | 2021-09-23 |
ES2890226T3 (es) | 2022-01-18 |
CA3043132A1 (en) | 2018-05-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2019005934A (es) | Compuestos de benzodiazolio como inhibidores del canal de sodio epitelial (enac). | |
MX2023001876A (es) | Derivados de rapamicina. | |
GEP20217248B (en) | 2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of dhodh | |
MX2020001757A (es) | Compuestos, sales de los mismos y metodos para el tratamiento de enfermedades. | |
PH12016502382A1 (en) | Substituted indazole compounds as irak4 inhibitors | |
PH12020500655A1 (en) | Compounds | |
MX2018006207A (es) | Compuestos heterociclicos como inmunomoduladores. | |
MX2022005160A (es) | Oxisteroles y metodos de uso de los mismos. | |
PH12017502363A1 (en) | Brk inhibitory compound | |
MX2017004234A (es) | Inhibidor del egfr y preparacion y aplicacion del mismo. | |
SG10201811384TA (en) | Mnk inhibitors and methods related thereto | |
MX2015011984A (es) | Inhibidores de bromodominio de dihidro-pirrolopiridinona. | |
PH12018500268A1 (en) | 2-amino-3-fluoro-3-(fluoromethyl)-6-methyl-6-phenyl-3,4,5,6-tetrahydropyridins as bace1 inhibitors | |
MY197698A (en) | Oxysterols and methods of use thereof | |
PH12015501363B1 (en) | Chloro-pyrazine carboxamide derivatives with epithelial sodium channel blocking activity | |
PH12019501690A1 (en) | Pyrimidine compound and pharmaceutical use thereof | |
MX2018005041A (es) | Compuestos para tratar la esclerosis lateral amiotrofica. | |
PH12016502130B1 (en) | Novel pyrrolopyrimidine compound or salt thereof, pharmaceutical composition containing same, especially agent for prevention and/or treatment of tumors etc based on nae inhibitory effect | |
MX2016001855A (es) | Nuevos aza-oxo-indoles para el tratamiento y profilaxis de la infeccion por virus sincitial respiratorio. | |
MX2018008307A (es) | Derivado de ascoclorina y uso del mismo como activador de proteina cinasa activada por adenosin monofosfato (ampk). | |
MX2024007360A (es) | Composiciones que comprenden compuestos de bisfluoroalquil-1,4-ben zodiacepinona y metodos de uso de las mismas. | |
PH12019500198A1 (en) | Compounds and compositions and uses thereof | |
MX2018001317A (es) | Inhibidores del virus sincitial respiratorio. | |
MX2017007955A (es) | Formas solidas que comprenden (1e, 4e)-2-amino-n,n-dipropil-8-(4-( pirrolidina-1-carbonil)fenil)-3h-benzo[b]azepina-4-carboxamida, composiciones de las mismas y usos de las mismas. | |
ZA202106519B (en) | Caspase inhibitors and methods of use thereof |