PT3544981T - Compostos de benzodiazólio como inibidores do enac - Google Patents
Compostos de benzodiazólio como inibidores do enacInfo
- Publication number
- PT3544981T PT3544981T PT178079000T PT17807900T PT3544981T PT 3544981 T PT3544981 T PT 3544981T PT 178079000 T PT178079000 T PT 178079000T PT 17807900 T PT17807900 T PT 17807900T PT 3544981 T PT3544981 T PT 3544981T
- Authority
- PT
- Portugal
- Prior art keywords
- benzodiazolium
- compounds
- enac inhibitors
- enac
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1619694.1A GB201619694D0 (en) | 2016-11-22 | 2016-11-22 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3544981T true PT3544981T (pt) | 2021-09-23 |
Family
ID=57993838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT178079000T PT3544981T (pt) | 2016-11-22 | 2017-11-22 | Compostos de benzodiazólio como inibidores do enac |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US10941149B2 (pt) |
| EP (1) | EP3544981B1 (pt) |
| JP (1) | JP6980014B2 (pt) |
| KR (1) | KR102517273B1 (pt) |
| CN (1) | CN110214141B (pt) |
| AU (1) | AU2017364308B2 (pt) |
| BR (1) | BR112019009864A2 (pt) |
| CA (1) | CA3043132A1 (pt) |
| DK (1) | DK3544981T3 (pt) |
| EA (1) | EA039607B1 (pt) |
| ES (1) | ES2890226T3 (pt) |
| GB (1) | GB201619694D0 (pt) |
| HU (1) | HUE055692T2 (pt) |
| IL (1) | IL266745B (pt) |
| MA (1) | MA46878A (pt) |
| MX (1) | MX2019005934A (pt) |
| PL (1) | PL3544981T3 (pt) |
| PT (1) | PT3544981T (pt) |
| TW (1) | TWI756305B (pt) |
| WO (1) | WO2018096325A1 (pt) |
| ZA (1) | ZA201902710B (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201610854D0 (en) | 2016-06-21 | 2016-08-03 | Entpr Therapeutics Ltd | Compounds |
| GB201619694D0 (en) * | 2016-11-22 | 2017-01-04 | Entpr Therapeutics Ltd | Compounds |
| GB201717051D0 (en) * | 2017-10-17 | 2017-11-29 | Enterprise Therapeutics Ltd | Compounds |
| GB201801355D0 (en) | 2018-01-26 | 2018-03-14 | Enterprise Therapeutics Ltd | Compounds |
| GB201808093D0 (en) * | 2018-05-18 | 2018-07-04 | Enterprise Therapeutics Ltd | Compounds |
| GB201908453D0 (en) | 2019-06-12 | 2019-07-24 | Enterprise Therapeutics Ltd | Compounds for treating respiratory disease |
| EP3983389A1 (en) | 2019-06-12 | 2022-04-20 | Tmem16A Limited | Compounds for treating respiratory disease |
| GB201910608D0 (en) * | 2019-07-24 | 2019-09-04 | Enterprise Therapeutics Ltd | Compounds |
| AR124316A1 (es) | 2020-12-11 | 2023-03-15 | Tmem16A Ltd | Compuestos para tratar una enfermedad respiratoria |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US6858614B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenolic guanidine sodium channel blockers |
| US6903105B2 (en) | 2003-02-19 | 2005-06-07 | Parion Sciences, Inc. | Sodium channel blockers |
| DK1663235T3 (da) | 2003-08-18 | 2013-10-28 | Parion Sciences Inc | Beskyttede pyrazinoylguanidin-natriumkanal-blokkere |
| AU2004264441A1 (en) | 2003-08-18 | 2005-02-24 | Parion Sciences, Inc. | Cyclic pyrazinoylguanidine sodium channel blockers |
| US20050090505A1 (en) | 2003-08-18 | 2005-04-28 | Johnson Michael R. | Methods of reducing risk of infection from pathogens |
| JP2007502827A (ja) | 2003-08-18 | 2007-02-15 | パリオン・サイエンシィズ・インコーポレーテッド | 脂肪族ピラジノイルグアニジンナトリウムチャネルブロッカー |
| US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
| RU2006118312A (ru) * | 2003-10-28 | 2007-12-10 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Бензимидазолы, полезные в качестве модуляторов ионных каналов |
| US7399766B2 (en) | 2004-08-18 | 2008-07-15 | Parion Sciences, Inc. | Soluble amide & ester pyrazinoylguanidine sodium channel blockers |
| NZ561029A (en) * | 2005-03-14 | 2011-03-31 | High Point Pharmaceuticals Llc | Benzazole dervatives, compositions, and method of use as beta-secretase inhibitors |
| US7807834B2 (en) | 2005-08-03 | 2010-10-05 | Parion Sciences, Inc. | Capped pyrazinoylguanidine sodium channel blockers |
| GB0526240D0 (en) | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
| GB0526244D0 (en) | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
| US8288391B2 (en) | 2007-04-03 | 2012-10-16 | Parion Sciences, Inc. | Pyrazinoylguanidine compounds for use as taste modulators |
| EP2332933A1 (en) | 2007-05-07 | 2011-06-15 | Novartis AG | Epithelial sodium channel (ENaC) inhibitors |
| WO2009019506A1 (en) | 2007-08-03 | 2009-02-12 | Astrazeneca Ab | Heterocyclyc sulfonamides having edg-1 antagonistic activity |
| CN101939054B (zh) | 2007-12-10 | 2014-10-29 | 诺华股份有限公司 | 有机化合物 |
| ES2485642T3 (es) | 2008-02-26 | 2014-08-14 | Parion Sciences, Inc. | Bloqueantes poli-aromáticos de los canales de sodio |
| EA201001772A1 (ru) | 2008-05-13 | 2011-06-30 | Новартис Аг | Производные 3,5-диамино-6-хлорпиразин-2-карбоновой кислоты и их применение в качестве блокаторов эпителиальных натриевых каналов для лечения заболеваний дыхательных путей |
| MX2010013675A (es) | 2008-06-10 | 2011-02-15 | Novartis Ag | Derivados de pirazina como bloqueadores del canal de sodio epitelial. |
| WO2011028740A1 (en) | 2009-09-03 | 2011-03-10 | Glaxo Group Limited | ENaC BLOCKERS |
| WO2011079087A1 (en) | 2009-12-23 | 2011-06-30 | Glaxo Group Limited | Enac blockers |
| US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
| TW201204353A (en) * | 2010-06-08 | 2012-02-01 | Vertex Pharma | Formulations of (R)-1-(2,2-difluorobenzo[D][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide |
| US8372845B2 (en) | 2010-09-17 | 2013-02-12 | Novartis Ag | Pyrazine derivatives as enac blockers |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| AP2014007670A0 (en) | 2011-11-02 | 2014-05-31 | Boehringer Ingelheim Int | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof |
| US8859559B2 (en) | 2011-12-20 | 2014-10-14 | Boehringer Ingelheim International Gmbh | Substituted pyrazines and their use in the treatment of disease |
| HUE039734T2 (hu) | 2012-05-29 | 2019-01-28 | Parion Sciences Inc | Nátriumcsatorna-blokkoló aktivitású, dendrimerszerû amino-amid-származékok száraz szem és más nyálkahártya-megbetegedések kezelésére |
| WO2014044849A1 (en) | 2012-09-24 | 2014-03-27 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof |
| KR20150095870A (ko) | 2012-12-17 | 2015-08-21 | 패리온 사이언스 인코퍼레이티드 | 3,5-디아미노-6-클로로-n-(n-(4-페닐부틸)카르밤이미도일)피라진-2-카르복스아미드 화합물 |
| CN105073717B (zh) | 2012-12-17 | 2018-05-22 | 帕里昂科学公司 | 可用于治疗由黏膜水化不足造成的疾病的氯-吡嗪甲酰胺衍生物 |
| CA2896686A1 (en) | 2012-12-17 | 2014-06-26 | Parion Sciences, Inc. | 3,5-diamino-6-chloro-n-(n-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds |
| JP6353032B2 (ja) | 2013-04-30 | 2018-07-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ジアミノピラジン化合物、前記化合物を含有する医薬、その使用、およびその調製方法 |
| JP2016525508A (ja) | 2013-07-02 | 2016-08-25 | ザ カリフォルニア インスティテュート フォー バイオメディカル リサーチ | 嚢胞性線維症の処置のための化合物 |
| JP6449870B2 (ja) | 2013-07-08 | 2019-01-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 肺および気道の疾患を処置するための上皮性ナトリウムチャネルの阻害剤としてのアミロライド型化合物 |
| WO2015007516A1 (en) | 2013-07-15 | 2015-01-22 | Boehringer Ingelheim International Gmbh | Novel 5-substituted benzimidazolium compounds |
| EP3022197B1 (en) | 2013-07-15 | 2017-09-06 | Boehringer Ingelheim International GmbH | Novel tetra- and pentasubstituted benzimidazolium compounds |
| WO2015007519A1 (en) | 2013-07-15 | 2015-01-22 | Boehringer Ingelheim International Gmbh | Novel benzimidazolium compounds |
| JP6449880B2 (ja) | 2013-08-08 | 2019-01-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ピラジンアミド化合物 |
| WO2016113169A1 (en) | 2015-01-12 | 2016-07-21 | Boehringer Ingelheim International Gmbh | Tetra- and pentasubstituted benzimidazolium compounds useful in the treatment of respiratory diseases |
| EP3245200B1 (en) | 2015-01-12 | 2021-03-10 | Boehringer Ingelheim International GmbH | 2-(pyrazin-2-ylcarbonylaminomethyl)benzimidazolium compounds as epithelial sodium channel inhibitors |
| JP6667538B2 (ja) | 2015-01-12 | 2020-03-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 呼吸器系疾患の治療に有用な置換ベンズイミダゾリウム化合物 |
| US10155749B2 (en) * | 2015-01-12 | 2018-12-18 | Boehringer Ingelheim International Gmbh | Substituted benzimidazolium compounds useful in the treatment of respiratory diseases |
| AU2015406099A1 (en) | 2015-08-20 | 2018-02-01 | Boehringer Ingelheim International Gmbh | Novel annelated benzamides |
| HUE046014T2 (hu) | 2015-08-20 | 2020-01-28 | Boehringer Ingelheim Int | Új anellált fenoxi-acetamidok |
| GB201610854D0 (en) * | 2016-06-21 | 2016-08-03 | Entpr Therapeutics Ltd | Compounds |
| GB201619694D0 (en) * | 2016-11-22 | 2017-01-04 | Entpr Therapeutics Ltd | Compounds |
-
2016
- 2016-11-22 GB GBGB1619694.1A patent/GB201619694D0/en not_active Ceased
-
2017
- 2017-11-22 PL PL17807900T patent/PL3544981T3/pl unknown
- 2017-11-22 TW TW106140573A patent/TWI756305B/zh active
- 2017-11-22 CA CA3043132A patent/CA3043132A1/en active Pending
- 2017-11-22 MX MX2019005934A patent/MX2019005934A/es unknown
- 2017-11-22 US US16/462,794 patent/US10941149B2/en active Active
- 2017-11-22 BR BR112019009864A patent/BR112019009864A2/pt active Search and Examination
- 2017-11-22 WO PCT/GB2017/053499 patent/WO2018096325A1/en unknown
- 2017-11-22 EP EP17807900.0A patent/EP3544981B1/en active Active
- 2017-11-22 AU AU2017364308A patent/AU2017364308B2/en active Active
- 2017-11-22 ES ES17807900T patent/ES2890226T3/es active Active
- 2017-11-22 KR KR1020197016141A patent/KR102517273B1/ko active IP Right Grant
- 2017-11-22 PT PT178079000T patent/PT3544981T/pt unknown
- 2017-11-22 MA MA046878A patent/MA46878A/fr unknown
- 2017-11-22 CN CN201780084165.3A patent/CN110214141B/zh active Active
- 2017-11-22 EA EA201991253A patent/EA039607B1/ru unknown
- 2017-11-22 JP JP2019527365A patent/JP6980014B2/ja active Active
- 2017-11-22 DK DK17807900.0T patent/DK3544981T3/da active
- 2017-11-22 HU HUE17807900A patent/HUE055692T2/hu unknown
-
2019
- 2019-04-30 ZA ZA2019/02710A patent/ZA201902710B/en unknown
- 2019-05-20 IL IL266745A patent/IL266745B/en unknown
-
2020
- 2020-11-24 US US17/103,559 patent/US11739094B2/en active Active
-
2023
- 2023-06-30 US US18/345,840 patent/US20240067653A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| TWI756305B (zh) | 2022-03-01 |
| TW201833111A (zh) | 2018-09-16 |
| CN110214141B (zh) | 2022-05-31 |
| BR112019009864A2 (pt) | 2019-08-27 |
| GB201619694D0 (en) | 2017-01-04 |
| EP3544981A1 (en) | 2019-10-02 |
| ES2890226T3 (es) | 2022-01-18 |
| KR20190084076A (ko) | 2019-07-15 |
| US20240067653A1 (en) | 2024-02-29 |
| MX2019005934A (es) | 2019-11-12 |
| AU2017364308B2 (en) | 2021-03-11 |
| JP2019535747A (ja) | 2019-12-12 |
| JP6980014B2 (ja) | 2021-12-15 |
| CA3043132A1 (en) | 2018-05-31 |
| MA46878A (fr) | 2019-10-02 |
| IL266745B (en) | 2021-12-01 |
| PL3544981T3 (pl) | 2021-12-20 |
| US10941149B2 (en) | 2021-03-09 |
| US20190315757A1 (en) | 2019-10-17 |
| CN110214141A (zh) | 2019-09-06 |
| ZA201902710B (en) | 2021-10-27 |
| US11739094B2 (en) | 2023-08-29 |
| US20210147432A1 (en) | 2021-05-20 |
| WO2018096325A1 (en) | 2018-05-31 |
| KR102517273B1 (ko) | 2023-04-03 |
| AU2017364308A1 (en) | 2019-05-23 |
| IL266745A (en) | 2019-07-31 |
| HUE055692T2 (hu) | 2021-12-28 |
| EP3544981B1 (en) | 2021-06-23 |
| EA201991253A1 (ru) | 2019-11-29 |
| EA039607B1 (ru) | 2022-02-16 |
| DK3544981T3 (da) | 2021-09-20 |
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