EA201892004A1 - Противовирусные средства для лечения гепатита b - Google Patents

Противовирусные средства для лечения гепатита b

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Publication number
EA201892004A1
EA201892004A1 EA201892004A EA201892004A EA201892004A1 EA 201892004 A1 EA201892004 A1 EA 201892004A1 EA 201892004 A EA201892004 A EA 201892004A EA 201892004 A EA201892004 A EA 201892004A EA 201892004 A1 EA201892004 A1 EA 201892004A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hepatitis
hbv
antiviral agents
compounds
virus
Prior art date
Application number
EA201892004A
Other languages
English (en)
Inventor
Яо-Линг Киу
Ксури Гао
Вей Ли
Хуэй Сао
Мейжонг Джин
Джорден Касс
Ксиаовен Пенг
Ят Сун Ор
Original Assignee
Энанта Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Энанта Фармасьютикалз, Инк. filed Critical Энанта Фармасьютикалз, Инк.
Priority claimed from PCT/US2017/020853 external-priority patent/WO2017155844A1/en
Publication of EA201892004A1 publication Critical patent/EA201892004A1/ru

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    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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Abstract

Данное изобретение раскрывает соединения формулы (I) или их фармацевтически приемлемые соли, эфиры или неактивные формыкоторые ингибируют белок (белки), кодируемый вирусом гепатита B (ВГВ), или нарушают функцию жизненного цикла ВГВ вируса гепатита B, а также полезны в качестве противовирусных средств. Данное изобретение дополнительно относится к фармацевтическим композициям, содержащим выше указанные соединения, для введения субъекту, страдающему от ВГВ-инфекции. Изобретение также относится к способам лечения ВГВ-инфекции у субъектов посредством введения фармацевтической композиции, содержащей соединения по данному изобретению.
EA201892004A 2016-05-17 2017-03-06 Противовирусные средства для лечения гепатита b EA201892004A1 (ru)

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US201662337675P 2016-05-17 2016-05-17
PCT/US2017/020853 WO2017155844A1 (en) 2016-03-07 2017-03-06 Hepatitis b antiviral agents

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