MX2021003253A - Heterociclos funcionalizados como agentes antivirales. - Google Patents

Heterociclos funcionalizados como agentes antivirales.

Info

Publication number
MX2021003253A
MX2021003253A MX2021003253A MX2021003253A MX2021003253A MX 2021003253 A MX2021003253 A MX 2021003253A MX 2021003253 A MX2021003253 A MX 2021003253A MX 2021003253 A MX2021003253 A MX 2021003253A MX 2021003253 A MX2021003253 A MX 2021003253A
Authority
MX
Mexico
Prior art keywords
antiviral agents
hbv
present
compounds
hepatitis
Prior art date
Application number
MX2021003253A
Other languages
English (en)
Inventor
Yat Sun Or
Joseph Panarese
Samuel Bartlett
Dexter Davis
Katherine Chong
Original Assignee
Enanta Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enanta Pharm Inc filed Critical Enanta Pharm Inc
Publication of MX2021003253A publication Critical patent/MX2021003253A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Abstract

La presente invención revela compuestos de Fórmula (I), o sales de uso farmacéutico aceptable de los mismos:(VER FORMULA) que inhiben la proteína o proteínas codificadas por el virus de la hepatitis B (HBV) o interfieren con la función del ciclo de vida del HBV del virus de la hepatitis B y también son útiles como agentes antivirales. La presente invención además se relaciona a composiciones farmacéuticas que comprenden los compuestos mencionados para la administración a un sujeto que sufre de infección por HBV. La invención también se relaciona a métodos de tratar una infección por HBV en un sujeto mediante la administración de una composición farmacéutica que comprende los compuestos de la presente invención.
MX2021003253A 2018-09-21 2019-09-20 Heterociclos funcionalizados como agentes antivirales. MX2021003253A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862734424P 2018-09-21 2018-09-21
PCT/US2019/052119 WO2020061435A1 (en) 2018-09-21 2019-09-20 Functionalized heterocycles as antiviral agents

Publications (1)

Publication Number Publication Date
MX2021003253A true MX2021003253A (es) 2021-08-11

Family

ID=69885310

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021003253A MX2021003253A (es) 2018-09-21 2019-09-20 Heterociclos funcionalizados como agentes antivirales.

Country Status (14)

Country Link
US (2) US10865211B2 (es)
EP (1) EP3852751A4 (es)
JP (1) JP2022500466A (es)
KR (1) KR20210065965A (es)
CN (1) CN112955142A (es)
AR (1) AR116474A1 (es)
AU (1) AU2019342750A1 (es)
BR (1) BR112021005091A2 (es)
CA (1) CA3113235A1 (es)
IL (1) IL281564A (es)
MX (1) MX2021003253A (es)
TW (1) TW202024093A (es)
UY (1) UY38383A (es)
WO (1) WO2020061435A1 (es)

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US11802125B2 (en) 2020-03-16 2023-10-31 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents

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