BR112018075465A2 - agentes antivirais de hepatite b - Google Patents
agentes antivirais de hepatite bInfo
- Publication number
- BR112018075465A2 BR112018075465A2 BR112018075465-0A BR112018075465A BR112018075465A2 BR 112018075465 A2 BR112018075465 A2 BR 112018075465A2 BR 112018075465 A BR112018075465 A BR 112018075465A BR 112018075465 A2 BR112018075465 A2 BR 112018075465A2
- Authority
- BR
- Brazil
- Prior art keywords
- hepatitis
- hbv
- present
- antiviral agents
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
a presente invenção revela compostos de fórmula (i), ou sais farmaceuticamente aceitáveis dos mesmos: que inibem a(s) proteína(s) codificada(s) por vírus da hepatite b (hbv) ou interferem na função do ciclo de vida de hbv do vírus da hepatite b e também são úteis como agentes antivirais. a presente invenção se refere, ainda, a composições farmacêuticas que compreendem os compostos mencionados anteriormente para a administração a um indivíduo que sofre de infecção de hbv. a invenção também se refere a métodos de tratamento de uma infecção de hbv em um indivíduo por meio da administração de uma composição farmacêutica que compreende os compostos da presente invenção.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662348419P | 2016-06-10 | 2016-06-10 | |
US62/348,419 | 2016-06-10 | ||
US201762443245P | 2017-01-06 | 2017-01-06 | |
US62/443,245 | 2017-01-06 | ||
PCT/US2017/036553 WO2017214395A1 (en) | 2016-06-10 | 2017-06-08 | Hepatitis b antiviral agents |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018075465A2 true BR112018075465A2 (pt) | 2019-03-19 |
Family
ID=60573663
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018075465-0A BR112018075465A2 (pt) | 2016-06-10 | 2017-06-08 | agentes antivirais de hepatite b |
Country Status (15)
Country | Link |
---|---|
US (3) | US10189846B2 (pt) |
EP (1) | EP3468561A4 (pt) |
JP (1) | JP2019521972A (pt) |
KR (1) | KR20190027814A (pt) |
CN (1) | CN109843296A (pt) |
AU (1) | AU2017277664A1 (pt) |
BR (1) | BR112018075465A2 (pt) |
CA (1) | CA3028228A1 (pt) |
CL (1) | CL2018003492A1 (pt) |
CO (1) | CO2019000069A2 (pt) |
IL (1) | IL263535A (pt) |
MX (1) | MX2018015315A (pt) |
PH (1) | PH12018550201A1 (pt) |
SG (1) | SG11201810834WA (pt) |
WO (1) | WO2017214395A1 (pt) |
Families Citing this family (55)
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2017
- 2017-06-08 AU AU2017277664A patent/AU2017277664A1/en not_active Abandoned
- 2017-06-08 WO PCT/US2017/036553 patent/WO2017214395A1/en unknown
- 2017-06-08 JP JP2018563674A patent/JP2019521972A/ja not_active Withdrawn
- 2017-06-08 CN CN201780048555.5A patent/CN109843296A/zh active Pending
- 2017-06-08 SG SG11201810834WA patent/SG11201810834WA/en unknown
- 2017-06-08 KR KR1020197000474A patent/KR20190027814A/ko unknown
- 2017-06-08 BR BR112018075465-0A patent/BR112018075465A2/pt not_active IP Right Cessation
- 2017-06-08 EP EP17811015.1A patent/EP3468561A4/en not_active Withdrawn
- 2017-06-08 CA CA3028228A patent/CA3028228A1/en not_active Abandoned
- 2017-06-08 US US15/617,445 patent/US10189846B2/en active Active
- 2017-06-08 MX MX2018015315A patent/MX2018015315A/es unknown
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2018
- 2018-12-03 PH PH12018550201A patent/PH12018550201A1/en unknown
- 2018-12-05 CL CL2018003492A patent/CL2018003492A1/es unknown
- 2018-12-06 IL IL263535A patent/IL263535A/en unknown
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2019
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2020
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WO2017214395A1 (en) | 2017-12-14 |
MX2018015315A (es) | 2019-04-25 |
IL263535A (en) | 2019-01-31 |
US20170355701A1 (en) | 2017-12-14 |
SG11201810834WA (en) | 2018-12-28 |
AU2017277664A1 (en) | 2019-01-24 |
CN109843296A (zh) | 2019-06-04 |
US20200317678A1 (en) | 2020-10-08 |
US10640511B2 (en) | 2020-05-05 |
EP3468561A4 (en) | 2019-12-04 |
KR20190027814A (ko) | 2019-03-15 |
CL2018003492A1 (es) | 2019-04-05 |
JP2019521972A (ja) | 2019-08-08 |
US20190119288A1 (en) | 2019-04-25 |
CO2019000069A2 (es) | 2019-02-08 |
US10189846B2 (en) | 2019-01-29 |
PH12018550201A1 (en) | 2019-04-08 |
CA3028228A1 (en) | 2017-12-14 |
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