CL2021001288A1 - Heterociclos funcionalizados como agentes antivirales - Google Patents

Heterociclos funcionalizados como agentes antivirales

Info

Publication number
CL2021001288A1
CL2021001288A1 CL2021001288A CL2021001288A CL2021001288A1 CL 2021001288 A1 CL2021001288 A1 CL 2021001288A1 CL 2021001288 A CL2021001288 A CL 2021001288A CL 2021001288 A CL2021001288 A CL 2021001288A CL 2021001288 A1 CL2021001288 A1 CL 2021001288A1
Authority
CL
Chile
Prior art keywords
hbv
antiviral agents
present
compounds
hepatitis
Prior art date
Application number
CL2021001288A
Other languages
English (en)
Inventor
Yat Sun Or
Joseph Panarese
Dexter Davis
Samuel Bartlett
Katherine Chong
Nathaniel Kenton
Original Assignee
Enanta Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enanta Pharm Inc filed Critical Enanta Pharm Inc
Publication of CL2021001288A1 publication Critical patent/CL2021001288A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención describe compuestos de Fórmula (I), o sales farmacéuticamente aceptables, de los mismos: que inhibe la (s) proteína (s) codificada por el virus de la hepatitis B (VHB) o interfiere con la función del ciclo de vida del VHB del virus de la hepatitis B y también son útiles como agentes antivirales. La presente invención se refiere además a composiciones farmacéuticas que comprenden los compuestos antes mencionados para su administración a un sujeto que padece una infección por VHB. La invención también se refiere a métodos para tratar una infección por VHB en un sujeto mediante la administración de una composición farmacéutica que comprende los compuestos de la presente invención
CL2021001288A 2018-11-21 2021-05-17 Heterociclos funcionalizados como agentes antivirales CL2021001288A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862770428P 2018-11-21 2018-11-21
US201962884486P 2019-08-08 2019-08-08

Publications (1)

Publication Number Publication Date
CL2021001288A1 true CL2021001288A1 (es) 2022-01-07

Family

ID=70770590

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2021001288A CL2021001288A1 (es) 2018-11-21 2021-05-17 Heterociclos funcionalizados como agentes antivirales

Country Status (17)

Country Link
US (2) US11198693B2 (es)
EP (1) EP3883570A4 (es)
JP (1) JP2022507724A (es)
KR (1) KR20210093951A (es)
CN (1) CN113271946A (es)
AU (1) AU2019385477A1 (es)
BR (1) BR112021009854A2 (es)
CA (1) CA3119973A1 (es)
CL (1) CL2021001288A1 (es)
CO (1) CO2021008055A2 (es)
IL (1) IL283190A (es)
MX (1) MX2021005850A (es)
PH (1) PH12021551116A1 (es)
SG (1) SG11202105007TA (es)
TW (1) TW202033524A (es)
UY (1) UY38483A (es)
WO (1) WO2020106816A1 (es)

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US11690847B2 (en) 2016-11-30 2023-07-04 Case Western Reserve University Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof
US11718589B2 (en) 2017-02-06 2023-08-08 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase

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US10865211B2 (en) 2018-09-21 2020-12-15 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
US11198693B2 (en) 2018-11-21 2021-12-14 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
WO2020247444A1 (en) 2019-06-03 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
WO2020247575A1 (en) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
WO2020247561A1 (en) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
WO2021007488A1 (en) 2019-07-11 2021-01-14 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
WO2021018207A1 (zh) * 2019-07-30 2021-02-04 上海挚盟医药科技有限公司 一类用于治疗和/或预防乙型肝炎病毒感染的化合物及其制备方法和应用
US11236108B2 (en) 2019-09-17 2022-02-01 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
US11802125B2 (en) 2020-03-16 2023-10-31 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents
CN117279909A (zh) * 2021-04-04 2023-12-22 巴鲁克斯布伦博格研究所 新型肝选择性聚腺苷酸化聚合酶抑制剂及其使用方法
WO2023230249A1 (en) * 2022-05-25 2023-11-30 Baruch S. Blumberg Institute Novel hepatoselective polyadenylating polymerases inhibitors and their method of use

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