KR20210141983A - Kcnt1 발현을 감소시키기 위한 화합물 및 방법 - Google Patents
Kcnt1 발현을 감소시키기 위한 화합물 및 방법 Download PDFInfo
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- KR20210141983A KR20210141983A KR1020217032716A KR20217032716A KR20210141983A KR 20210141983 A KR20210141983 A KR 20210141983A KR 1020217032716 A KR1020217032716 A KR 1020217032716A KR 20217032716 A KR20217032716 A KR 20217032716A KR 20210141983 A KR20210141983 A KR 20210141983A
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Abstract
세포 또는 대상체에서 KCNT1 RNA의 양 또는 활성을 감소시키고, 특정 예에서는 세포 또는 대상체에서 KCNT1 단백질의 양을 감소시키기 위한 화합물, 방법 및 약제학적 조성물이 제공된다. 이러한 화합물, 방법 및 약제학적 조성물은 신경학적 병태의 적어도 하나의 증상 또는 특징을 개선하는데 유용하다. 이러한 증상 및 특징은 발작, 뇌병증 및 행동 이상을 포함한다. 이러한 화합물, 방법 및 약제학적 조성물로부터 유익을 얻을 수 있는 신경학적 병태의 비제한적인 예는 이동성 초점성 발작을 동반한 유아기의 뇌전증(EIMFS), 상염색체 우성 야간 전두엽 간질(ADNFLE), 웨스트 증후군 및 오타하라 증후군이다.
Description
서열 목록
본 출원은 전자 포맷의 서열 목록과 함께 출원되어 있다. 상기 서열 목록은 크기가 716kb이고 2020년 3월 9일자로 작성된 BIOL0358WOSEQ_ST25.txt의 파일명으로 제공된다. 서열 목록의 이러한 전자 포맷의 정보는 전문이 본 명세서에 참조에 의해 포함된다.
기술분야
세포 또는 대상체에서 칼륨 나트륨-활성화 채널 서브패밀리 T 구성원 1(potassium sodium-activated channel subfamily T member 1: KCNT1) RNA의 양을 감소시키고, 특정 예에서는 세포 또는 대상체에서 KCNT1 단백질의 양을 감소시키기 위한 화합물, 방법 및 약제학적 조성물이 제공된다. 이러한 화합물, 방법 및 약제학적 조성물은 신경학적 병태의 적어도 하나의 증상 또는 특징을 개선하는데 유용하다. 이러한 증상 및 특징은 뇌병증, 대뇌 피질 위축(cerebral cortical atrophy), 클로누스(clonus), 발작(뇌전증), 및 행동 이상 예컨대, 공격성, 긴장증, 정신병 및 지적 장애를 포함하지만 이들로 제한되지 않는다. 본 명세서에 개시된 화합물, 방법 및 약제학적 조성물로 치료될 수 있는 신경학적 병태의 비제한적인 예는 이동성 초점성 발작을 동반한 유아기의 뇌전증(epilepsy of infancy with migrating focal seizure: EIMFS), 상염색체 우성 야간 전두엽 간질(autosomal dominant nocturnal frontal lobe epilepsy: ADNFLE), 및 웨스트 증후군(West syndrome) 및 오타하라 증후군(Ohtahara syndrome)을 비롯한 조기 발병 간질성 뇌병증(early onset epileptic encephalopathy)이다.
뇌전증은 뇌 활동의 주기적인 이상을 특징으로 하는 신경학적 장애이다. 비제한적인 예로서, 뇌전증을 갖는 개인은 종종 비정상적인 행동, 예컨대, 발작(통제할 수 없는 사지의 경련 또는 떨림), 의식상실, 긴장증 혼돈 및 정신병을 나타낸다. 간질성 개인은 초점성 발작 또는 전신 발작을 경험할 수 있다. 초점성 발작은 뇌의 특정 영역에 영향을 미친다. 이에 반해서, 전신 발작은 뇌의 모든 영역에 영향을 미친다. 비극적으로, EIMFS를 갖는 환자 및 영아 간질성 뇌병증(EIEE)을 갖는 환자에서 볼 수 있는 바와 같이, 뇌전증의 발병은 생후 첫 몇 개월 이내에 발생할 수 있다. EIMFS는 뇌전증에서 갑작스러운 예기치 않은 사망률이 높은 중증 약물-내성 뇌전증이다. EIMFS 대상체에서 발작의 발병은 종종 생후 첫 달에 일어난다.
칼슘 활성화 K+ 채널 유사 서열(Sequence Like a Calcium Activated K+ channel: SLACK), KCa4.1 및 Slo2.2라고도 공지된 KCNT1은 KCNT2와 함께 사량체 채널을 형성하여 다양한 범위의 신경 세포에서 나트륨-민감성 칼륨 전류를 매개하는 나트륨 게이팅 칼륨 채널 소단위이다. KCNT1 mRNA의 2개의 스플라이스 아이소폼이 인간에서 발현된다. 이러한 아이소폼은 설치류에서 발견되는 SLACK 아이소폼 변이체와 유사한 상이한 전기물리학적 특성을 갖는 상이한 단백질을 생산할 수 있다.
KCNT1에서 기능 돌연변이의 획득은 ADNFLE 및 EIMFS를 포함한 몇몇 유형의 뇌전증을 유발할 수 있다. 현재까지, 간질 대상체에서 발견되는 모든 KCNT1 돌연변이는 KCNT1 단백질 기능 획득을 초래하는 미스센스 돌연변이이다. 이러한 미스센스 돌연변이는 칼륨 채널 활성을 증가시키고, 최대 칼륨 전류를 증가시킨다. EIMFS 사례의 대략 42 내지 50%는 기능 돌연변이의 KCNT1 획득 때문이다.
현재, 영아 뇌병증 및 뇌전증을 치료하기 위한 허용 가능한 선택이 부족하다. 따라서, 이러한 병태는 상당한 충족되지 못한 요구가 있다. 또한, 약물-내성인 다수 사례의 뇌전증이 존재하여, 환자는 치료 선택이 거의 없거나 전혀 없다. 따라서 본 명세서에는 이러한 질환을 치료하기 위한 화합물, 방법 및 약제학적 조성물을 제공하는 것이 목적이다.
본 명세서에는 KCNT1 RNA의 양 또는 활성을 감소시키고, 특정 실시형태에서는 세포 또는 대상체에서 KCNT1 단백질의 활성을 감소시키기 위한 화합물, 방법 및 약제학적 조성물이 제공된다. 특정 실시형태에서 대상체는 인간 영아이다. 특정 실시형태에서, 대상체는 신경학적 병태를 갖는다. 특정 실시형태에서, 신경학적 병태는 뇌병증을 포함한다. 특정 실시형태에서, 신경학적 병태는 뇌전증을 포함한다. 특정 실시형태에서, 신경학적 병태는 EIMFS이다. 특정 실시형태에서, 신경학적 병태는 ADNFLE이다. 특정 실시형태에서, KCNT1 RNA의 양 또는 활성을 감소시키는데 유용한 화합물은 올리고머 화합물이다. 특정 실시형태에서, KCNT1 RNA의 발현을 감소시키는데 유용한 화합물은 변형된 올리고뉴클레오타이드이다.
또한 본 명세서에는 신경학적 병태의 적어도 하나의 증상 또는 특징을 개선하는데 유용한 방법이 제공된다. 특정 실시형태에서, 신경학적 병태는 EIMFS이다. 특정 실시형태에서, 신경학적 병태는 ADNFLE이다. 특정 실시형태에서, 적어도 하나의 증상 또는 특징은 발작, 뇌 손상, 탈수초(demyelination), 근기능 저하(hypotonia), 소두증(microcephaly), 우울증, 불안, 인지 기능으로부터 선택된다. 특정 실시형태에서, 본 명세서에 개시된 방법은 발작 발생을 감소시키는데 유용하다. 특정 실시형태에서, 본 명세서에 개시된 방법은 발작 중증도를 감소시키는데 유용하다.
전술한 일반적인 설명 및 하기의 상세한 설명은 단지 예시 및 설명을 위한 것이며 제한적인 것이 아님을 이해해야 한다. 본 명세서에서, 단수형의 사용은 달리 특별히 언급되지 않는 한, 복수형을 포함한다. 본 명세서에서 사용된 바와 같이, "또는"의 사용은 달리 언급되지 않는 한, "및/또는"을 의미한다. 더욱이, 용어 "포함하는" 뿐만 아니라 다른 형태들, 예컨대, "포함하다" 및 "포함된"의 사용은 제한적이지 않다. 또한, "요소" 또는 "성분"과 같은 용어는 달리 특별히 언급되지 않는 한, 하나의 단위를 포함하는 요소들 및 성분들 그리고 하나 이상의 소단위를 포함하는 요소들 및 성분들 둘 다를 포함한다.
본 명세서에서 사용된 섹션 제목은 단지 구조화 목적을 위한 것이며 기재된 주제를 제한하는 것으로 해석되어서는 안 된다. 특허, 특허 출원, 기사, 서적 및 논문을 포함하지만 이들로 제한되지 않는 본 출원에 인용된 모든 문서 또는 문서의 일부는 본 명세서에 논의된 문서의 일부뿐만 아니라 그 전문이 명백히 본 명세서에 참조에 의해 포함된다.
정의
특정 정의가 제공되지 않는 한, 본 명세서에 기재된 내용과 관련하여 사용되는 명명법, 및 본 명세서에 기재된 분석 화학, 합성 유기 화학 및 약물 및 제약학적 화학의 절차 및 기술은 당업계에 널리 공지되어 있으며 통상적으로 사용되는 것이다. 허용 가능한 한, 개시내용 전반에 걸쳐 언급되는 모든 특허, 출원, 공개 출원 및 기타 간행물 및 기타 데이터는 그 전문이 본 명세서에 참조에 의해 포함된다.
달리 나타내지 않는 한, 하기 용어는 다음 의미를 갖는다:
정의
본 명세서에서 사용된 바와 같이, "2'-데옥시뉴클레오사이드"는 2'-H(H) 데옥시리보실 당 모이어티를 포함하는 뉴클레오사이드를 의미한다. 특정 실시형태에서, 2'-데옥시뉴클레오사이드는 2'-β-D-데옥시뉴클레오사이드이고, 자연 발생 데옥시리보핵산(DNA)에서 발견되는 바와 같이 β-D 배위를 갖는 2'-β-D-데옥시리보실 당 모이어티를 포함한다. 특정 실시형태에서, 비변형된 2'-데옥시리보실 당 모이어티를 포함하는 2'-데옥시뉴클레오사이드 또는 뉴클레오사이드는 변형된 핵염기를 포함할 수 있거나 또는 RNA 핵염기(유라실)를 포함할 수 있다.
본 명세서에서 사용된 바와 같이, "2'-MOE" 또는 "2'-MOE 당 모이어티"는 리보실 당 모이어티의 2'-OH기 대신 2'-OCH2CH2OCH3 를 의미한다. "MOE"는 메톡시에틸을 의미한다.
본 명세서에서 사용된 바와 같이, "2'-MOE 뉴클레오사이드"는 2'-MOE 당 모이어티를 포함하는 뉴클레오사이드를 의미한다.
본 명세서에서 사용된 바와 같이, "2'-OMe" 또는 "2'-O-메틸 당 모이어티"는 리보실 당 모이어티의 2'-OH기 대신에 2'-OCH3기를 의미한다.
본 명세서에서 사용된 바와 같이, "2'-OMe 뉴클레오사이드"는 2'-OMe 당 모이어티를 포함하는 뉴클레오사이드를 의미한다.
본 명세서에 사용된 바와 같이, "2'-치환된 뉴클레오사이드"는 2'-치환된 당 모이어티를 포함하는 뉴클레오사이드를 의미한다. 본 명세서에서 사용된 바와 같이, 당 모이어티에 대한 언급에서 "2'-치환된"은 H 또는 OH 이외의 적어도 하나의 2'-치환기를 포함하는 당 모이어티를 의미한다.
본 명세서에서 사용된 바와 같이, "5-메틸 사이토신"은 5 위치에 부착된 메틸기로 변형된 사이토신을 의미한다. 5-메틸 사이토신은 변형된 핵염기이다.
본 명세서에서 사용된 바와 같이, "투여하는"은 약제학적 작용제를 대상체에게 제공하는 것을 의미한다.
본 명세서에서 사용된 바와 같이, "안티센스 활성"은 그 표적 핵산에 대한 안티센스 화합물의 혼성화로 인한 임의의 검출 가능한 그리고/또는 측정 가능한 변화를 의미한다. 특정 실시형태에서, 안티센스 활성은 안티센스 화합물의 부재 하에서 표적 핵산 수준 또는 표적 단백질 수준에 비해 그러한 표적 핵산에 의해 암호화된 표적 핵산 또는 단백질의 양 또는 발현의 감소이다.
본 명세서에서 사용된 바와 같이, "안티센스 화합물"은 적어도 하나의 안티센스 활성을 달성할 수 있는 올리고머 화합물을 의미한다.
본 명세서에서 사용된 바와 같이, 치료에 대한 언급에서 "개선하다"는 치료의 부재 하에서 동일한 증상에 비해 적어도 하나의 증상이 개선됨을 의미한다. 특정 실시형태에서, 개선은 증상의 중증도 또는 빈도의 감소 또는 발병 지연 또는 증상의 중증도 또는 빈도의 진행 둔화이다.
본 명세서에 사용된 바와 같이, "이환식 뉴클레오사이드" 또는 "BNA"는 이환식 당 모이어티를 포함하는 뉴클레오사이드를 의미한다.
본 명세서에 사용된 바와 같이, "이환식 당" 또는 "이환식 당 모이어티"는 2개의 고리를 포함하는 변형된 당 모이어티를 의미하고, 여기서, 제2 고리는 제1 고리 내의 원자 중 2개를 연결하는 브리지를 통해 형성되어서 이환식 구조를 형성한다. 특정 실시형태에서, 이환식 당 모이어티의 제1 고리는 퓨라노실 모이어티이다. 특정 실시형태에서, 이환식 당 모이어티는 퓨라노실 모이어티를 포함하지 않는다.
본 명세서에 사용된 바와 같이, "절단 가능한 모이어티"는 예를 들어, 세포 또는 대상체 내에의 생리학적 조건 하에서 절단된 원자의 결합 또는 군을 의미한다.
본 명세서에 사용된 바와 같이, 올리고뉴클레오타이드에 대한 언급에서 "상보성"은, 올리고뉴클레오타이드 및 다른 핵산의 핵염기 서열이 반대 방향으로 정렬될 때 올리고뉴클레오타이드 또는 이의 하나 이상의 영역의 핵염기 및 또 다른 핵산 또는 이의 하나 이상의 영역의 핵염기의 적어도 70%가 서로 수소 결합을 할 수 있음을 의미한다. 본 명세서에서 사용된 바와 같이, "상보성 핵염기"는 서로와 수소 결합을 형성할 수 있는 핵염기를 의미한다. 상보성 핵염기 쌍은 아데닌(A)과 티민(T), 아데닌(A)과 유라실(U), 사이토신(C)과 구아닌(G), 5-메틸 사이토신(mC)과 구아닌(G)을 포함한다. 상보성 올리고뉴클레오타이드 및/또는 핵산은 각각의 뉴클레오사이드에서 핵염기 상보성을 가질 필요는 없다. 오히려, 일부 미스매치가 용인된다. 본 명세서에서 사용된 바와 같이, 올리고뉴클레오타이드에 대한 언급에서 "완전히 상보성" 또는 "100% 상보성"은 올리고뉴클레오타이드의 각각의 뉴클레오사이드에서 또 다른 올리고뉴클레오타이드 또는 핵산에 상보성임을 의미한다.
본 명세서에서 사용된 바와 같이, "접합체 기"는 올리고뉴클레오타이드에 직접 또는 간접적으로 부착된 원자의 기를 의미한다. 접합체 기는 접합체 모이어티 및 접합체 모이어티를 올리고뉴클레오타이드에 부착시키는 접합체 링커를 포함한다.
본 명세서에서 사용된 바와 같이, "접합체 링커"는 접합체 모이어티를 올리고뉴클레오타이드에 연결하는 적어도 하나의 결합을 포함하는 원자의 기를 의미한다.
본 명세서에서 사용된 바와 같이, "접합체 모이어티"는 접합체 링커를 통해 올리고뉴클레오타이드에 부착된 원자의 기를 의미한다.
본 명세서에 사용된 바와 같이, 올리고뉴클레오타이드의 맥락에서 "인접한"은 뉴클레오사이드, 핵염기, 당 모이어티, 또는 서로에 바로 근접한 뉴클레오사이드간 링키지(internucleoside linkage)를 지칭한다. 예를 들어, "인접한 핵염기"는 서열에서 서로에 바로 근접한 핵염기를 의미한다.
본 명세서에서 사용된 바와 같이, "구속된(constrained) 에틸" 또는 "cEt" 또는 "cEt 변형된 당"은 β-D 리보실 이환식 당 모이어티를 의미하며, 여기서, 이환식 당의 제2 고리는 β-D 리보실 당 모이어티의 4'-탄소 및 2'-탄소를 연결하는 브리지를 통해 형성되며, 브리지는 화학식 4'-CH(CH3)-O-2'를 가지며, 브리지의 메틸기는 S 배위로 존재한다.
본 명세서에서 사용된 바와 같이, "cEt 뉴클레오사이드"는 cEt 변형된 당을 포함하는 뉴클레오사이드를 의미한다.
본 명세서에 사용된 바와 같이, "카이럴적으로 풍부한(chirally enriched) 집단"은, 특정 카이럴 중심에서 특정 입체화학 배위를 함유하는 집단 내의 분자의 수 또는 백분율이, 특정 카이럴 중심이 입체무작위인 경우, 집단 내의 동일한 특정 카이럴 중심에서 동일한 특정 입체화학 배위를 함유하는 것으로 예상된 분자의 수 또는 백분율보다 큰, 동일한 분자식의 복수의 분자를 의미한다. 각각의 분자 내에 다수의 카이럴 중심을 갖는 카이럴적으로 풍부한 분자의 집단은 하나 이상의 입체무작위 카이럴 중심을 함유할 수 있다. 특정 실시형태에서, 분자는 변형된 올리고뉴클레오타이드이다. 특정 실시형태에서, 분자는 변형된 올리고뉴클레오타이드를 포함하는 화합물이다.
본 명세서에서 사용된 바와 같이, "갭머(gapmer)"는 하나 이상의 뉴클레오사이드를 갖는 외부 영역들 사이에 위치되어 있는, RNase H 절단을 지지하는 복수의 뉴클레오사이드를 갖는 내부 영역을 포함하는 변형된 올리고뉴클레오타이드를 의미하며, 여기서, 내부 영역을 포함하는 뉴클레오사이드는 외부 영역을 포함하는 뉴클레오사이드 또는 뉴클레오사이드와 화학적으로 구별된다. 내부 영역은 "갭"으로 지칭될 수 있으며, 외부 영역은 "윙(wing)"으로 지칭될 수 있다. 달리 나타내지 않는 한, "갭머"는 당 모티프를 지칭한다. 달리 나타내지 않는 한, 갭머의 갭의 각각의 뉴클레오사이드의 당 모이어티는 비변형된 2'-β-D-데옥시리보실 당 모이어티이다. 따라서, 용어 "MOE 갭머"는 2'-β-D-데옥시뉴클레오사이드를 포함하는 갭 및 2'-MOE 뉴클레오사이드를 포함하는 윙을 갖는 갭머를 나타낸다. 달리 나타내지 않는 한, MOE 갭머는 하나 이상의 변형된 뉴클레오사이드간 링키지 및/또는 변형된 핵염기를 포함할 수 있으며, 그러한 변형은 당 변형의 갭머 패턴을 반드시 따르는 것은 아니다.
본 명세서에서 사용된 바와 같이, "핫스팟(hotspot) 영역"은 표적 핵산의 양 또는 활성의 올리고머 화합물-매개된 감소에 대해 변형 가능한 표적 핵산 상의 다양한 핵염기이다.
본 명세서에서 사용된 바와 같이, "혼성화"는 상보성 올리고뉴클레오타이드 및/또는 핵산의 짝지움 또는 어닐링을 의미한다. 특정 기전으로 제한하고자 함은 아니지만, 가장 통상적인 혼성화 기전은 상보성 핵염기 간의 수소 결합을 포함하며, 이러한 수소 결합은 왓슨-크릭, 후그스틴 또는 역 후그스틴 수소 결합일 수 있다.
본 명세서에서 사용된 바와 같이, 용어 "뉴클레오사이드간 링키지"는 올리고뉴클레오타이드 내의 인접한 뉴클레오사이드 간의 공유 링키지이다. 본 명세서에 사용된 바와 같이, "변형된 뉴클레오사이드간 링키지"는 포스포다이에스터 뉴클레오사이드간 링키지 이외의 임의의 뉴클레오사이드간 링키지를 의미한다. "포스포로티오에이트 뉴클레오사이드간 링키지"는 포스포다이에스터 뉴클레오사이드간 링키지의 비-가교 산소 원자 중 하나가 황 원자로 대체되는 변형된 뉴클레오사이드간 링키지이다.
본 명세서에서 사용된 바와 같이, "링커-뉴클레오사이드"는 올리고뉴클레오타이드를 접합체 모이어티에 직접 또는 간접적으로 연결하는 뉴클레오사이드를 의미한다. 링커-뉴클레오사이드는 올리고머 화합물의 접합체 링커 내에 위치한다. 링커-뉴클레오사이드는 이들이 올리고뉴클레오타이드와 인접하더라도 올리고머 화합물의 올리고뉴클레오타이드 부분의 일부로 간주되지 않는다.
본 명세서에서 사용된 바와 같이, "비-이환식 변형된 당 모이어티"는 당의 2개 원자 사이에 브리지를 형성하여 제2 고리를 형성하지 않는 변형을 포함하는 변형된 당 모이어티, 예컨대, 치환기를 의미한다.
본 명세서에서 사용된 바와 같이, "미스매치" 또는 "비-상보성"은 제1 올리고뉴클레오타이드와 제2 올리고뉴클레오타이드가 정렬될 때 제2 올리고뉴클레오타이드 또는 표적 핵산의 상응하는 핵염기와 상보성이지 않은 제1 올리고뉴클레오타이드의 핵염기를 의미한다.
본 명세서에서 사용된 바와 같이, "모티프"는 올리고뉴클레오타이드 내의 비변형된 및/또는 변형된 당 모이어티, 핵염기 및/또는 뉴클레오사이드간 링키지의 패턴을 의미한다.
본 명세서에서 사용된 바와 같이, "신경학적 병태"는 뇌, 중추 신경계, 말초 신경계 또는 이들의 조합의 병태를 의미한다. 신경학적 병태는 신경 기능부전, 신경 손상 및 신경 사멸 중 적어도 하나를 특징으로 할 수 있다. 신경학적 병태는 운동 기능 감소를 포함할 수 있다. 신경학적 병태는 운동 제어 감소를 포함할 수 있다.
본 명세서에서 사용된 바와 같이, "핵염기"는 비변형된 핵염기 또는 변형된 핵염기를 의미한다. 본 명세서에 사용된 바와 같이, "비변형된 핵염기"는 아데닌(A), 타이민(T), 사이토신(C), 유라실(U) 또는 구아닌(G)이다. 본 명세서에 사용된 바와 같이, "변형된 핵염기"는 적어도 하나의 비변형된 핵염기와 쌍을 지을 수 있는 비변형된 A, T, C, U 또는 G 이외의 원자의 군이다. "5-메틸 사이토신"은 변형된 핵염기이다. 만능 염기(universal base)는 5개의 비변형된 핵염기 중 어느 하나와 짝지워질 수 있는 변형된 핵염기이다. 본 명세서에서 사용된 바와 같이, "핵염기 서열"은 임의의 당 또는 뉴클레오사이드간 링키지 변형과 관계없이 핵산 또는 올리고뉴클레오타이드 내의 인접한 핵염기의 순서를 의미한다.
본 명세서에서 사용된 바와 같이, "뉴클레오사이드"는 핵염기 및 당 모이어티를 포함하는 화합물을 의미한다. 핵염기 및 당 모이어티는 각각 독립적으로 비변형되거나 변형된다. 본 명세서에서 사용된 바와 같이, "변형된 뉴클레오사이드"는 변형된 핵염기 및/또는 변형된 당 모이어티를 포함하는 뉴클레오사이드를 의미한다. 변형된 뉴클레오사이드는 비염기성(abasic) 뉴클레오사이드를 포함하는데, 이것은 핵염기가 결핍되어 있다. "연결된 뉴클레오사이드"는 인접한 서열 내에 연결되어 있는 뉴클레오사이드이다(즉, 연결되는 뉴클레오사이드 사이에 어떠한 추가의 뉴클레오사이드도 존재하지 않는다).
본 명세서에서 사용된 바와 같이, "올리고머 화합물"은 올리고뉴클레오타이드 및 선택적으로 하나 이상의 추가의 특징, 예컨대, 접합체 기 또는 말단 기를 의미한다. 올리고머 화합물은 제1 올리고머 화합물과 상보성인 제2 올리고 화합물과 쌍을 이룰 수 있거나 쌍을 이룰 수 없다. "단일-가닥 올리고머 화합물"은 쌍을 이루지 않은 올리고머 화합물이다. 용어 "올리고머 듀플렉스"는 상보성 핵염기 서열을 갖는 2개의 올리고머 화합물에 의해 형성된 듀플렉스를 의미한다. 올리고머 듀플렉스의 각각의 올리고머 화합물은 "듀플렉스화된 올리고머 화합물"로 지칭될 수 있다.
본 명세서에서 사용된 바와 같이, "올리고뉴클레오타이드"는 뉴클레오사이드간 링키지를 통해 연결되는 연결된 뉴클레오사이드의 가닥을 의미하며, 여기서, 각각의 뉴클레오사이드 및 뉴클레오사이드간 링키지는 변형 또는 비변형될 수 있다. 달리 나타내지 않는 한, 올리고뉴클레오타이드는 8 내지 50개의 연결된 뉴클레오사이드로 이루어진다. 본 명세서에서 사용된 바와 같이, "변형된 올리고뉴클레오타이드"는 적어도 하나의 뉴클레오사이드 또는 뉴클레오사이드간 링키지가 변형된 올리고뉴클레오타이드를 의미한다. 본 명세서에서 사용된 바와 같이, "비변형된 올리고뉴클레오타이드"는 임의의 뉴클레오사이드 변형 또는 뉴클레오사이드간 변형을 포함하지 않는 올리고뉴클레오타이드를 의미한다.
본 명세서에서 사용된 바와 같이, "약제학적으로 허용 가능한 담체 또는 희석제"는 대상체에 투여 시 사용하기에 적합한 임의의 물질을 의미한다. 이러한 특정 담체는 약제학적 조성물이, 예를 들어, 대상체에 의한 경구 섭취를 위한 정제, 환제, 드라제, 캡슐, 액체, 겔, 시럽, 슬러리, 현탁액 및 로젠지로 제형화될 수 있게 한다. 특정 실시형태에서, 약제학적으로 허용 가능한 담체 또는 희석제는 멸균수, 멸균 식염수, 멸균 완충액 또는 멸균 인공 뇌척수액이다.
본 명세서에서 사용된 바와 같이, "약제학적으로 허용 가능한 염"은 화합물의 생리학적으로 그리고 약제학적으로 허용 가능한 염을 의미한 다. 약제학적으로 허용 가능한 염은 모 화합물의 바람직한 생물학적 활성을 유지하며, 이에 바람직하지 않은 독물학적 효과를 부여하지 않는다.
본 명세서에서 사용된 바와 같이, "약제학적 조성물"은 대상체에게 투여하기에 적합한 물질의 혼합물을 의미한다. 예를 들어, 약제학적 조성물은 올리고머 화합물 및 멸균 수용액을 포함할 수 있다. 특정 실시형태에서, 약제학적 조성물은 특정 세포주에서 자유 흡수 검정(free uptake assay)에서의 활성을 나타낸다.
본 명세서에서 사용된 바와 같이, "전구약물"은 대상체 또는 이의 세포 내에서 상이한 형태로 전환되는 신체 외부에서의 형태의 치료제를 의미한다. 전형적으로, 대상체 내에서의 전구약물의 전환은 세포 또는 조직에 존재하는 효소(예를 들어, 내인성 또는 바이러스 효소)의 작용에 의해 그리고/또는 생리학적 조건에 의해 촉진된다.
본 명세서에서 사용된 바와 같이, "양 또는 활성을 감소시키거나 저해하는"는 미처리 샘플 또는 대조군 샘플에서의 전사 발현 또는 활성에 대한 전사 발현 또는 활성의 감소 또는 차단을 지칭하며, 반드시 전사 발현 또는 활성의 완전한 제거를 나타내는 것은 아니다.
본 명세서에서 사용된 바와 같이, "RNA"는 RNA 전사체를 의미하며, 달리 명시되지 않는 한 프리-mRNA 및 성숙 mRNA를 포함한다.
본 명세서에서 사용된 바와 같이, "RNAi 화합물"은, 적어도 부분적으로, RISC 또는 Ago2를 통해 작용하여 표적 핵산 및/또는 표적 핵산에 의해 암호화되는 단백질을 조절하는 안티센스 화합물을 의미한다. RNAi 화합물은 이중-가닥 siRNA, 단일-가닥 RNA(ssRNA) 및 마이크로RNA 모방체를 포함한 마이크로RNA를 포함하지만 이들로 제한되지 않는다. 특정 실시형태에서, RNAi 화합물은 표적 핵산의 양, 활성 및/또는 스플라이싱을 조절한다. 용어 RNAi 화합물은 RNase H를 통해 작용하는 안티센스 화합물을 제외한다.
본 명세서에서 사용된 바와 같이, 올리고뉴클레오타이드에 대한 언급에서 "자가-상보성"은 적어도 부분적으로 그 자신에 혼성화하는 올리고뉴클레오타이드를 의미한다.
본 명세서에서 사용된 바와 같이, "표준 세포 검정"은 실시예 1에 기재된 검정 및 이의 타당한 변형을 의미한다.
본 명세서에서 사용된 바와 같이, 동일한 분자식의 분자 집단과 관련하여 "입체무작위 카이럴 중심"은 무작위 입체화학 배위를 갖는 카이럴 중심을 의미한다. 예를 들어, 입체무작위 카이럴 중심을 포함하는 분자의 집단에서, 입체무작위 카이럴 중심의 (S) 배위를 갖는 분자의 수는 입체무작위 카이럴 중심의 (R) 배위를 갖는 분자의 수와 동일할 수 있지만 반드시 그러한 것은 아니다. 카이럴 중심의 입체화합 배위는 입체화학 배위를 제어하도록 설계되지 않은 합성 방법의 결과인 경우, 무작위인 것으로 간주된다. 특정 실시형태에서, 입체무작위 카이럴 중심은 입체무작위 포스포로티오에이트 뉴클레오사이드간 링키지이다.
본 명세서에서 사용된 바와 같이, "대상체"는 인간 또는 비-인간 동물을 의미한다. 특정 실시형태에서, 대상체는 인간이다.
본 명세서에서 사용된 바와 같이, "당 모이어티"는 비변형된 당 모이어티 또는 변형된 당 모이어티를 의미한다. 본 명세서에서 사용된 바와 같이, "비변형된 당 모이어티"는 RNA에서 발견되는 바와 같은 2'-OH(H) 리보실 모이어티("비변형된 RNA 당 모이어티") 또는 DNA에서 발견되는 바와 같은 2'-H(H) 데옥시리보실 모이어티("비변형된 DNA 당 모이어티")를 의미한다. 비변형된 당 모이어티는 각각 1', 3', 및 4' 위치에서 1개의 수소, 3' 위치에서 산소 및 5' 위치에서 2개의 수소를 갖는다. 본 명세서에서 사용된 바와 같이, "변형된 당 모이어티" 또는 "변형된 당"은 변형된 퓨라노실 당 모이어티 또는 당 대용체를 의미한다.
본 명세서에서 사용된 바와 같이, "당 대용체"는 핵염기를 또 다른 기, 예컨대, 올리고뉴클레오타이드의 뉴클레오사이드간 링키지, 접합체 기 또는 말단 기에 연결시킬 수 있는 퓨라노실 모이어티 이외의 것을 갖는 변형된 당 모이어티를 의미한다. 당 대용체를 포함하는 변형된 뉴클레오사이드는 올리고뉴클레오타이드 내의 하나 이상의 위치에 혼입될 수 있으며, 그러한 올리고뉴클레오타이드는 상보성 올리고머 화합물 또는 표적 핵산에 혼성화할 수 있다.
본 명세서에서 사용된 바와 같이, "증상 또는 특징"은 질환 또는 장애의 존재 또는 정도를 나타내는 임의의 물리적 특징부 또는 시험 결과를 의미한다. 특정 실시형태에서, 증상은 대상체 또는 상기 대상체를 조사하거나 시험하는 의료 전문가에게 자명하다. 특정 실시형태에서, 특징은 검시 시험(post-mortem test)을 포함하지만 이에 제한되지 않는 침습성 진단 검사 시에 자명하다.
본 명세서에서 사용된 바와 같이, "표적 핵산" 및 "표적 RNA"는 안티센스 화합물이 영향을 미치도록 설계된 핵산을 의미한다.
본 명세서에서 사용된 바와 같이, "표적 영역"은 올리고머 화합물이 혼성화되도록 설계된 표적 핵산의 일부를 의미한다.
본 명세서에서 사용된 바와 같이, "말단 기"는 올리고뉴클레오타이드의 말단에 공유적으로 연결되는 화학기 또는 원자의 기를 의미한다.
본 명세서에서 사용된 바와 같이, "치료적 유효량"은 대상체에게 치료 유익을 제공하는 약제학적 작용제의 양을 의미한다. 예를 들어, 치료적 유효량은 질환의 증상을 개선시킨다.
특정 실시형태
본 개시내용은 하기 비제한적인 넘버링된 실시형태를 제공한다:
실시형태 1. 12 내지 50개의 연결된 뉴클레오사이드로 이루어진 변형된 올리고뉴클레오타이드를 포함하는 올리고머 화합물로서, 상기 변형된 올리고뉴클레오타이드의 핵염기 서열은 KCNT1 핵산의 동일한 길이 부분과 적어도 90% 상보성이고, 상기 변형된 올리고뉴클레오타이드는 변형된 당 모이어티 및 변형된 뉴클레오사이드간 링키지로부터 선택된 적어도 하나의 변형을 포함하는, 올리고머 화합물.
실시형태 2. 변형된 올리고뉴클레오타이드를 포함하는 올리고머 화합물로서, 상기 변형된 올리고뉴클레오타이드는 12 내지 50개의 연결된 뉴클레오사이드로 이루어지고, 서열번호 21 내지 2939 중 어느 것의 적어도 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 또는 20개의 인접한 핵염기를 포함하는 핵염기 서열을 갖는, 올리고머 화합물.
실시형태 3. 변형된 올리고뉴클레오타이드를 포함하는 올리고머 화합물로서, 상기 변형된 올리고뉴클레오타이드는 12 내지 50개의 연결된 뉴클레오사이드로 이루어지고,
서열번호 2의 핵염기 24523 내지 24561의 동일한 길이 부분,
서열번호 2의 핵염기 27568 내지 27603의 동일한 길이 부분,
서열번호 2의 핵염기 30772 내지 30811의 동일한 길이 부분,
서열번호 2의 핵염기 54372 내지 54428의 동일한 길이 부분,
서열번호 2의 핵염기 55785 내지 55818의 동일한 길이 부분,
서열번호 2의 핵염기 56048 내지 56073의 동일한 길이 부분,
서열번호 2의 핵염기 56319 내지 56349의 동일한 길이 부분,
서열번호 2의 핵염기 57683 내지 57710의 동일한 길이 부분,
서열번호 2의 핵염기 61117 내지 61153의 동일한 길이 부분,
서열번호 2의 핵염기 71033 내지 71060의 동일한 길이 부분,
서열번호 2의 핵염기 87135-87174의 동일한 길이 부분,
서열번호 2의 핵염기 92109 내지 92149의 동일한 길이 부분,
서열번호 2의 핵염기 94221 내지 94280의 동일한 길이 부분,
서열번호 2의 핵염기 94352 내지 94380의 동일한 길이 부분,
서열번호 2의 핵염기 94993 내지 95036의 동일한 길이 부분,
서열번호 2의 핵염기 95074 내지 95144의 동일한 길이 부분과 상보성인 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 적어도 17개, 적어도 18개, 적어도 19개 또는 적어도 20개의 인접한 핵염기를 포함하는 핵염기 서열을 갖는, 올리고머 화합물.
실시형태 4. 변형된 올리고뉴클레오타이드를 포함하는 올리고머 화합물로서, 상기 변형된 올리고뉴클레오타이드는 12 내지 50개의 연결된 뉴클레오사이드로 이루어지고,
서열번호 2의 핵염기 16586 내지 16649의 동일한 길이 부분,
서열번호 2의 핵염기 16586 내지 17823의 동일한 길이 부분,
서열번호 2의 핵염기 16586 내지 18663의 동일한 길이 부분,
서열번호 2의 핵염기 19220 내지 20568의 동일한 길이 부분,
서열번호 2의 핵염기 23003 내지 25391의 동일한 길이 부분,
서열번호 2의 핵염기 27095 내지 29908의 동일한 길이 부분,
서열번호 2의 핵염기 30452 내지 30891의 동일한 길이 부분,
서열번호 2의 핵염기 31773 내지 34427의 동일한 길이 부분,
서열번호 2의 핵염기 38458 내지 47003의 동일한 길이 부분,
서열번호 2의 핵염기 40432 내지 42873의 동일한 길이 부분,
서열번호 2의 핵염기 44414 내지 45718의 동일한 길이 부분,
서열번호 2의 핵염기 52096 내지 52153의 동일한 길이 부분,
서열번호 2의 핵염기 52096 내지 58525의 동일한 길이 부분,
서열번호 2의 핵염기 59308 내지 61697의 동일한 길이 부분,
서열번호 2의 핵염기 60111 내지 61697의 동일한 길이 부분,
서열번호 2의 핵염기 65270 내지 67169의 동일한 길이 부분,
서열번호 2의 핵염기 65270 내지 67150의 동일한 길이 부분,
서열번호 2의 핵염기 67026 내지 67065의 동일한 길이 부분,
서열번호 2의 핵염기 67026 내지 67087의 동일한 길이 부분,
서열번호 2의 핵염기 67648 내지 68527의 동일한 길이 부분,
서열번호 2의 핵염기 67955 내지 67998의 동일한 길이 부분,
서열번호 2의 핵염기 68515 내지 68583의 동일한 길이 부분,
서열번호 2의 핵염기 68538 내지 68592의 동일한 길이 부분,
서열번호 2의 핵염기 68571 내지 70874의 동일한 길이 부분,
서열번호 2의 핵염기 71037 내지 71313의 동일한 길이 부분,
서열번호 2의 핵염기 71037 내지 71184의 동일한 길이 부분,
서열번호 2의 핵염기 72851 내지 72887의 동일한 길이 부분,
서열번호 2의 핵염기 79368 내지 79483의 동일한 길이 부분,
서열번호 2의 핵염기 86554 내지 90150의 동일한 길이 부분,
서열번호 2의 핵염기 88332 내지 88448의 동일한 길이 부분,
서열번호 2의 핵염기 91686 내지 95485의 동일한 길이 부분,
서열번호 2의 핵염기 91686 내지 94431의 동일한 길이 부분 또는
서열번호 2의 핵염기 94219 내지 94275의 동일한 길이 부분과 상보성인 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 적어도 17개, 적어도 18개, 적어도 19개 또는 적어도 20개의 인접한 핵염기를 포함하는 핵염기 서열을 갖는, 올리고머 화합물.
실시형태 5. 실시형태 1 내지 4 중 어느 하나에 있어서, 상기 변형된 올리고뉴클레오타이드는 변형된 올리고뉴클레오타이드의 전체 핵염기 서열에 걸쳐서 측정되는 경우 서열번호 1 내지 3으로부터 선택된 핵염기 서열의 동일한 길이 부분과 적어도 80%, 85%, 90%, 95% 또는 100% 상보성인 핵염기를 갖는, 올리고머 화합물.
실시형태 6. 실시형태 1 내지 5 중 어느 하나에 있어서, 적어도 하나의 변형된 뉴클레오사이드는 변형된 당 모이어티를 포함하는, 올리고머 화합물.
실시형태 7. 실시형태 6에 있어서, 상기 변형된 당 모이어티는 이환식 당 모이어티를 포함하는, 올리고머 화합물.
실시형태 8. 실시형태 7에 있어서, 상기 이환식 당 모이어티는 -O-CH2-; 및 -O-CH(CH3)-로부터 선택된 2'-4' 브리지를 포함하는, 올리고머 화합물.
실시형태 9. 실시형태 6에 있어서, 상기 변형된 당 모이어티는 비-이환식 변형된 당 모이어티를 포함하는, 올리고머 화합물.
실시형태 10. 실시형태 9에 있어서, 상기 비-이환식 변형된 당 모이어티는 2'-MOE 당 모이어티 또는 2'-OMe 당 모이어티를 포함하는, 올리고머 화합물.
실시형태 11. 실시형태 1 내지 5 중 어느 하나에 있어서, 적어도 하나의 변형된 뉴클레오사이드는 당 대용체를 포함하는, 올리고머 화합물.
실시형태 12. 실시형태 11에 있어서, 상기 당 대용체는 몰폴리노 및 PNA로부터 선택되는, 올리고머 화합물.
실시형태 13. 실시형태 1 내지 12 중 어느 하나에 있어서, 상기 변형된 올리고뉴클레오타이드는,
1 내지 5개의 연결된 5'-영역 뉴클레오사이드로 이루어진 5'-영역;
6 내지 10개의 연결된 중심 영역 뉴클레오사이드로 이루어진 중심 영역; 및
1 내지 5개의 연결된 3'-영역 뉴클레오사이드로 이루어진 3'-영역을 포함하되;
상기 5'-영역 뉴클레오사이드 각각 및 상기 3'-영역 뉴클레오사이드 각각은 변형된 당 모이어티를 포함하고, 상기 중심 영역 뉴클레오사이드 각각은 비변형된 2'-데옥시리보실 당 모이어티를 포함하는, 올리고머 화합물.
실시형태 14. 실시형태 1 내지 13 중 어느 하나에 있어서, 상기 변형된 올리고뉴클레오타이드는 적어도 하나의 변형된 뉴클레오사이드간 링키지를 포함하는, 올리고머 화합물.
실시형태 15. 실시형태 14에 있어서, 상기 변형된 올리고뉴클레오타이드의 각각의 뉴클레오사이드간 링키지는 변형된 뉴클레오사이드간 링키지인, 올리고머 화합물.
실시형태 16. 실시형태 14 또는 15에 있어서, 상기 변형된 뉴클레오사이드간 링키지는 포스포로티오에이트 뉴클레오사이드간 링키지인, 올리고머 화합물.
실시형태 17. 실시형태 14 또는 16에 있어서, 상기 변형된 올리고뉴클레오타이드는 적어도 하나의 포스포다이에스터 뉴클레오사이드간 링키지를 포함하는, 올리고머 화합물.
실시형태 18. 실시형태 14, 16 및 17 중 어느 하나에 있어서, 뉴클레오사이드간 링키지 각각은 포스포다이에스터 뉴클레오사이드간 링키지 또는 포스포로티오에이트 뉴클레오사이드간 링키지로부터 독립적으로 선택되는, 올리고머 화합물.
실시형태 19. 실시형태 1 내지 18 중 어느 하나에 있어서, 상기 변형된 올리고뉴클레오타이드는 적어도 하나의 변형된 핵염기를 포함하는, 올리고머 화합물.
실시형태 20. 실시형태 19에 있어서, 상기 변형된 핵염기는 5-메틸 사이토신인, 올리고머 화합물.
실시형태 21. 실시형태 1 내지 20 중 어느 하나에 있어서, 상기 변형된 올리고뉴클레오타이드는 12 내지 30개, 12 내지 22개, 12 내지 20개, 14 내지 20개, 15 내지 25개, 16 내지 20개, 18 내지 22개 또는 18 내지 20개의 연결된 뉴클레오사이드로 이루어지는, 올리고머 화합물.
실시형태 22. 실시형태 1 내지 21 중 어느 하나에 있어서, 상기 변형된 올리고뉴클레오타이드는 20개의 연결된 뉴클레오사이드로 이루어지는, 올리고머 화합물.
실시형태 23. 실시형태 22에 있어서, 상기 변형된 올리고뉴클레오타이드는 뉴클레오사이드간 링키지 모티프 soooossssssssssooss를 가지며, "s"는 포스포로티오에이트 뉴클레오사이드간 링키지를 나타내고, "o"는 포스포다이에스터 뉴클레오사이드간 링키지를 나타내는, 올리고머 화합물.
실시형태 24. 실시형태 1 내지 23 중 어느 하나에 있어서, 상기 변형된 올리고뉴클레오타이드로 이루어진, 올리고머 화합물.
실시형태 25. 실시형태 1 내지 23 중 어느 하나에 있어서, 접합체 모이어티 및 접합체 링커를 포함하는, 접합체 기를 포함하는, 올리고머 화합물.
실시형태 26. 실시형태 25에 있어서, 상기 접합체 기는 1 내지 3개의 GalNAc 리간드를 포함하는 GalNAc 클러스터를 포함하는, 올리고머 화합물.
실시형태 27. 실시형태 25 또는 26에 있어서, 상기 접합체 링커는 단일 결합으로 이루어진, 올리고머 화합물.
실시형태 28. 실시형태 25에 있어서, 상기 접합체 링커는 절단 가능한, 올리고머 화합물.
실시형태 29. 실시형태 28에 있어서, 상기 접합체 링커는 1 내지 3개의 링커-뉴클레오사이드를 포함하는, 올리고머 화합물.
실시형태 30. 실시형태 25 내지 29 중 어느 하나에 있어서, 상기 접합체 기는 상기 변형된 올리고뉴클레오타이드의 5'-단부에서 상기 변형된 올리고뉴클레오타이드에 접합되어 있는, 올리고머 화합물.
실시형태 31. 실시형태 25 내지 29 중 어느 하나에 있어서, 상기 접합체 기는 상기 변형된 올리고뉴클레오타이드의 3'-단부에서 상기 변형된 올리고뉴클레오타이드에 접합되어 있는, 올리고머 화합물.
실시형태 32. 실시형태 1 내지 31 중 어느 하나에 있어서, 말단 기를 포함하는, 올리고머 화합물.
실시형태 33. 실시형태 1 내지 32 중 어느 하나에 있어서, 상기 올리고머 화합물은 단일-가닥 올리고머 화합물인, 올리고머 화합물.
실시형태 34. 실시형태 1 내지 28 및 30 내지 31 중 어느 하나에 있어서, 상기 올리고머 화합물은 링커-뉴클레오사이드를 포함하지 않는, 올리고머 화합물.
실시형태 35. 실시형태 1 내지 34 중 어느 하나에 있어서, 상기 올리고머 화합물의 상기 변형된 올리고뉴클레오타이드는 염이며, 상기 염은 나트륨염 또는 칼륨염인, 올리고머 화합물.
실시형태 36. 실시형태 1 내지 32, 34 및 35 중 어느 하나의 올리고머 화합물을 포함하는 올리고머 듀플렉스.
실시형태 37. 실시형태 1 내지 35 중 어느 하나의 올리고머 화합물 또는 실시형태 36의 올리고머 듀플렉스를 포함하거나 또는 이들로 이루어진, 안티센스 화합물.
실시형태 38. 실시형태 1 내지 35 중 어느 하나의 올리고머 화합물 또는 실시형태 36의 올리고머 듀플렉스 및 약제학적으로 허용 가능한 담체 또는 희석제를 포함하는, 약제학적 조성물.
실시형태 39. 실시형태 38에 있어서, 상기 약제학적으로 허용 가능한 희석제는 인공 척수액 또는 PBS인, 약제학적 조성물.
실시형태 40. 실시형태 39에 있어서, 상기 약제학적 조성물은 상기 변형된 올리고뉴클레오타이드 및 인공 척수액으로 본질적으로 이루어진, 약제학적 조성물.
실시형태 41. 대상체에게 실시형태 38 내지 40 중 어느 하나의 약제학적 조성물을 투여하는 단계를 포함하는 방법.
실시형태 42. 신경학적 병태의 치료 방법으로서, 상기 신경학적 병태를 갖거나 이의 발병 위험이 있는 개체에게 치료적 유효량의 실시형태 38 내지 40 중 어느 하나의 약제학적 조성물을 투여하는 단계; 및 이에 의해서 상기 신경학적 병태를 치료하는 단계를 포함하는, 신경학적 병태의 치료 방법.
실시형태 43. 신경학적 병태를 갖거나 이의 발병 위험이 있는 개체의 중추 신경계에서 KCNT1 RNA 또는 KCNT1 단백질을 감소시키는 방법으로서, 치료적 유효량의 실시형태 38 내지 40 중 어느 하나에 따른 약제학적 조성물을 투여하는 단계; 및 이에 의해서 상기 중추 신경계에서 KCNT1 RNA 또는 KCNT1 단백질을 감소시키는 단계를 포함하는, KCNT1 RNA 또는 KCNT1 단백질을 감소시키는 방법.
실시형태 44. 실시형태 42 또는 43에 있어서, 상기 신경학적 병태는 뇌병증을 포함하는, 방법.
실시형태 45. 실시형태 42 또는 43에 있어서, 상기 신경학적 병태는 뇌전증을 포함하는, 방법.
실시형태 46. 실시형태 42 또는 43에 있어서, 상기 신경학적 병태는 영아 뇌전증을 포함하는, 방법.
실시형태 47. 실시형태 46에 있어서, 상기 영아 뇌전증은 이동성 초점성 발작을 동반한 유아기의 뇌전증(EIMFS)인, 방법.
실시형태 48. 실시형태 42 또는 43에 있어서, 상기 신경학적 병태는 상염색체 우성 야간 전두엽 간질(ADNFLE)인, 방법.
실시형태 49. 실시형태 42 내지 48 중 어느 하나에 있어서, 상기 투여는 척추강내 투여에 의한 것인, 방법.
실시형태 50. 실시형태 42 내지 49 중 어느 하나에 있어서, 상기 신경학적 병태 중 적어도 하나의 증상 또는 특징이 개선되는, 방법.
실시형태 51. 실시형태 50에 있어서, 상기 증상 또는 특징은 발작, 뇌 손상, 탈수초, 근기능 저하, 소두증, 우울증, 불안, 인지 기능으로부터 선택되는, 방법.
실시형태 52. 실시형태 42 내지 51 중 어느 하나에 있어서, 상기 방법은 질환 퇴행을 예방하거나 둔화시키는, 방법.
실시형태 53. 세포에서 KCNT1 RNA를 감소시키는 방법으로, 상기 세포를 실시형태 1 내지 35 중 어느 하나에 따른 올리고머 화합물, 실시형태 36에 따른 올리고머 듀플렉스 또는 실시형태 37에 따른 안티센스 화합물과 접촉시키는 단계; 및 이에 의해서 상기 세포에서 KCNT1 RNA를 감소시키는 단계를 포함하는, 세포에서 KCNT1 RNA를 감소시키는 방법.
실시형태 4. 세포에서 KCNT1 단백질을 감소시키는 방법으로, 상기 세포를 실시형태 1 내지 35 중 어느 하나에 따른 올리고머 화합물, 실시형태 36에 따른 올리고머 듀플렉스 또는 실시형태 37에 따른 안티센스 화합물과 접촉시키는 단계; 및 이에 의해서 상기 세포에서 KCNT1 단백질을 감소시키는 단계를 포함하는, 세포에서 KCNT1 단백질을 감소시키는 방법.
I. 특정 올리고뉴클레오타이드
특정 실시형태에서, 본 명세서에는 연결된 뉴클레오사이드로 이루어진 올리고뉴클레오타이드를 포함하는 올리고머 화합물이 제공된다. 올리고뉴클레오타이드는 비변형된 올리고뉴클레오타이드(RNA 또는 DNA)일 수 있거나, 변형된 올리고뉴클레오타이드일 수 있다. 변형된 올리고뉴클레오타이드는 비변형된 RNA 또는 DNA에 비해 적어도 하나의 변형을 포함한다. 즉, 변형된 올리고뉴클레오타이드는 적어도 하나의 변형된 뉴클레오사이드(변형된 당 모이어티 및/또는 변형된 핵염기 포함) 및/또는 적어도 하나의 변형된 뉴클레오사이드간 링키지를 포함한다.
A.
특정 변형된 뉴클레오사이드
변형된 뉴클레오사이드는 변형된 당 모이어티 또는 변형된 핵염기 또는 변형된 당 모이어티 및 변형된 핵염기 둘 다를 포함한다.
1.
특정 당 모이어티
특정 실시형태에서, 변형된 당 모이어티는 비-이환식 변형된 당 모이어티이다. 특정 실시형태에서, 변형된 당 모이어티는 이환식 또는 삼환식 당 모이어티이다. 특정 실시형태에서, 변형된 당 모이어티는 당 대용체이다. 이러한 당 대용체는 변형된 당 모이어티의 다른 유형의 것에 상응하는 하나 이상의 치환을 포함할 수 있다.
특정 실시형태에서, 변형된 당 모이어티는 하나 이상의 치환기를 갖는 퓨라노실 고리를 포함하는 비-이환식 변형된 당 모이어티이고, 이들 치환기 중 어느 것도 이환식 구조를 형성하도록 퓨라노실 고리의 2개의 원자를 브리징하지 않는다. 이러한 비-브리징 치환기는 2', 4', 및/또는 5' 위치에서의 치환기(이들로 제한되지 않음)를 포함하는 퓨라노실의 임의의 위치에 있을 수 있다. 특정 실시형태에서, 비-이환식 변형된 당 모이어티의 하나 이상의 비-브리징 치환기는 분지형이다. 비-이환식 변형된 당 모이어티에 적합한 2'-치환기의 예는 2'-F, 2'-OCH3("OMe" 또는 "O-메틸") 및 2'-O(CH2)2OCH3 ("MOE")을 포함하지만, 이들로 제한되지 않는다. 특정 실시형태에서, 2'-치환기는 할로, 알릴, 아미노, 아지도, SH, CN, OCN, CF3, OCF3, O-C1-C10 알콕시, O-C1-C10 치환된 알콕시, O-C1-C10 알킬, O-C1-C10 치환된 알킬, S-알킬, N(Rm)-알킬, O-알켄일, S-알켄일, N(Rm)-알켄일, O-알킨일, S-알킨일, N(Rm)-알킨일, O-알킬렌일-O-알킬, 알킨일, 알크아릴, 아르알킬, O-알크아릴, O-아르알킬, O(CH2)2SCH3, O(CH2)2ON(Rm)(Rn) 또는 OCH2C(=O)-N(Rm)(Rn)(식 중, Rm 및 Rn은 각각 독립적으로, H, 아미노 보호기 또는 치환된 또는 비치환된 C1-C10 알킬임) 및 U.S. 6,531,584(Cook 등); U.S. 5,859,221(Cook 등); 및 U.S. 6,005,087(Cook 등)에 기재된 2'-치환기로부터 선택된다. 이들 2'-치환기의 특정 실시형태는 하이드록실, 아미노, 알콕시, 카복시, 벤질, 페닐, 나이트로(NO2), 티올, 티오알콕시, 티오알킬, 할로겐, 알킬, 아릴, 알켄일 및 알킨일로부터 독립적으로 선택된 하나 이상의 치환기에 의해 추가로 치환될 수 있다. 비-이환식 변형된 당 모이어티에 적합한 4'-치환기의 예는 알콕시(예를 들어, 메톡시), 알킬, 및 WO 2015/106128(Manoharan 등)에 기재된 것을 포함하지만, 이들로 제한되지 않는다. 비-이환식 변형된 당 모이어티에 적합한 5'-치환기의 예는 5-메틸(R 또는 S), 5'-바이닐 및 5'-메톡시를 포함하지만, 이들로 제한되지 않는다. 특정 실시형태에서, 비-이환식 변형된 당 모이어티는 하나 초과의 비-브리징 당 치환기, 예를 들어 2'-F-5'-메틸 당 모이어티 및 WO 2008/101157(Migawa 등) 및 US2013/0203836(Rajeev 등)에 기재된 변형된 당 모이어티 및 변형된 뉴클레오사이드를 포함한다.
특정 실시형태에서, 2'-치환된 비-이환식 변형된 뉴클레오사이드는 F, NH2, N3, OCF3, OCH3, O(CH2)3NH2, CH2CH=CH2, OCH2CH=CH2, OCH2CH2OCH3, O(CH2)2SCH3, O(CH2)2ON(Rm)(Rn), O(CH2)2O(CH2)2N(CH3)2 및 N-치환된 아세트아마이드(OCH2C(=O)-N(Rm)(Rn))(여기서, Rm 및 Rn은 각각 독립적으로 H, 아미노 보호기, 또는 치환된 또는 비치환된 C1-C10 알킬임)로부터 선택된 비-브리징 2'-치환기를 포함하는 당 모이어티를 포함한다.
특정 실시형태에서, 2'-치환된 뉴클레오사이드 비-이환식 변형된 뉴클레오사이드는 F, OCF3, OCH3, OCH2CH2OCH3, O(CH2)2SCH3, O(CH2)2ON(CH3)2, O(CH2)2O(CH2)2N(CH3)2 및 OCH2C(=O)-N(H)CH3("NMA")으로부터 선택된 비-브리징 2'-치환기를 포함하는 당 모이어티를 포함한다.
특정 실시형태에서, 2'-치환된 비-이환식 변형된 뉴클레오사이드는 F, OCH3 및 OCH2CH2OCH3로부터 선택된 비-브리징 2'-치환기를 포함하는 당 모이어티를 포함한다.
특정 변형된 당 모이어티는 퓨라노실 고리의 2개의 원자를 브리징하여 제2 고리를 형성하여, 이환식 당 모이어티를 생성시키는 치환기를 포함한다. 이러한 특정 실시형태에서, 이환식 당 모이어티는 4'와 2'의 퓨라노스 고리 원자 사이에 브리지를 포함한다. 이러한 4' 내지 2' 브리징 당 치환기의 예는 4'-CH2-2', 4'-(CH2)2-2', 4'-(CH2)3-2', 4'-CH2-O-2'("LNA"), 4'-CH2-S-2', 4'-(CH2)2-O-2'("ENA"), 4'-CH(CH3)-O-2'("구속된 에틸" 또는 "cEt"라고 지칭됨), 4'-CH2-O-CH2-2', 4'-CH2-N(R)-2', 4'-CH(CH2OCH3)-O-2'("구속된 MOE" 또는 "cMOE") 및 이의 유사체(예를 들어, U.S. 7,399,845(Seth 등), U.S. 7,569,686(Bhat 등), U.S. 7,741,457(Swayze 등) 및 U.S. 8,022,193(Swayze 등)), 4'-C(CH3)(CH3)-O-2' 및 이의 유사체(예를 들어, U.S. 8,278,283(Seth 등)), 4'-CH2-N(OCH3)-2' 및 이의 유사체(예를 들어, U.S. 8,278,425(Prakash 등)), 4'-CH2-O-N(CH3)-2'(예를 들어, U.S. 7,696,345(Allerson 등) 및 U.S. 8,124,745(Allerson 등)), 4'-CH2-C-(H)(CH3)-2'(예를 들어, 문헌[Zhou, et al., J. Org. Chem.,2009, 74, 118-134] 참조), 4'-CH2-C-(=CH2)-2' 및 이의 유사체(예를 들어, U.S. 8,278,426(Seth 등)), 4'-C(RaRb)-N(R)-O-2', 4'-C(RaRb)-O-N(R)-2', 4'-CH2-O-N(R)-2' 및 4'-CH2-N(R)-O-2'(여기서, R, Ra 및 Rb는 각각 독립적으로 H, 보호기 또는 C1-C12 알킬임)(예를 들어, U.S. 7,427,672(Imanishi 등))을 포함하지만, 이들로 제한되지 않는다.
특정 실시형태에서, 이러한 4' 내지 2' 브리지는 독립적으로 -[C(Ra)(Rb)]n-, -[C(Ra)(Rb)]n-O-, -C(Ra)=C(Rb)-, -C(Ra)=N-, -C(=NRa)-, -C(=O)-, -C(=S)-, -O-, -Si(Ra)2-, -S(=O)x- 및 -N(Ra)-로부터 독립적으로 선택된 1개 내지 4개의 연결된 기를 포함하고;
식 중,
x는 0, 1 또는 2이고;
n은 1, 2, 3 또는 4이고;
Ra 및 Rb는 각각 독립적으로 H, 보호기, 하이드록실, C1-C12 알킬, 치환된 C1-C12 알킬, C2-C12 알켄일, 치환된 C2-C12 알켄일, C2-C12 알킨일, 치환된 C2-C12 알킨일, C5-C20 아릴, 치환된 C5-C20 아릴, 헤테로사이클 라디칼, 치환된 헤테로사이클 라디칼, 헤테로아릴, 치환된 헤테로아릴, C5-C7 지환식 라디칼, 치환된 C5-C7 지환식 라디칼, 할로겐, OJ1, NJ1J2, SJ1, N3, COOJ1, 아실(C(=O)-H), 치환된 아실, CN, 설포닐(S(=O)2-J1) 또는 설폭실(S(=O)-J1)이고;
J1 및 J2는 각각 독립적으로 H, C1-C12 알킬, 치환된 C1-C12 알킬, C2-C12 알켄일, 치환된 C2-C12 알켄일, C2-C12 알킨일, 치환된 C2-C12 알킨일, C5-C20 아릴, 치환된 C5-C20 아릴, 아실(C(=O)-H), 치환된 아실, 헤테로사이클 라디칼, 치환된 헤테로사이클 라디칼, C1-C12 아미노알킬, 치환된 C1-C12 아미노알킬 또는 보호기이다.
추가적인 이환식 당 모이어티는 당업계에 공지되어 있고, 예를 들어 문헌[Freier et al., Nucleic Acids Research, 1997, 25(22), 4429-4443, Albaek et al., J. Org. Chem., 2006, 71, 7731-7740, Singh et al., Chem. Commun., 1998, 4, 455-456; Koshkin et al., Tetrahedron, 1998, 54, 3607-3630; Kumar et al., Bioorg. Med. Chem. Lett., 1998, 8, 2219-2222; Singh et al., J. Org. Chem., 1998, 63, 10035-10039; Srivastava et al., J. Am. Chem. Soc., 2007, 129, 8362-8379]; U.S. 7,053,207(Wengel 등); U.S. 6,268,490(Imanishi 등); U.S. 6,770,748(Imanishi 등); U.S. RE44,779(Imanishi 등); U.S. 6,794,499(Wengel 등); U.S. 6,670,461(Wengel 등); U.S. 7,034,133(Wengel 등); U.S. 8,080,644(Wengel 등); U.S. 8,034,909(Wengel 등); U.S. 8,153,365(Wengel 등); U.S. 7,572,582(Wengel 등); 및 U.S. 6,525,191(Ramasamy 등); WO 2004/106356(Torsten 등); WO 1999/014226(Wengel 등); WO 2007/134181(Seth 등); U.S. 7,547,684(Seth 등); U.S. 7,666,854(Seth 등); U.S. 8,088,746(Seth 등); U.S. 7,750,131(Seth 등); U.S. 8,030,467(Seth 등); U.S. 8,268,980(Seth 등); U.S. 8,546,556(Seth 등); U.S. 8,530,640(Seth 등); U.S. 9,012,421(Migawa 등); U.S. 8,501,805(Seth 등); 및 미국 특허 공보 US 2008/0039618(Allerson 등) 및 US2015/0191727(Migawa 등)을 참조하기 바란다.
특정 실시형태에서, 이러한 이환식 당 모이어티를 도입한 이환식 당 모이어티 및 뉴클레오사이드는 이성질체 배위로 추가로 정의된다. 예를 들어, (본 명세서에 기재된) LNA 뉴클레오사이드는 α-L 배위 또는 β-D 배위일 수 있다.
α-L-메틸렌옥시(4'-CH2-O-2') 또는 α-L-LNA 이환식 뉴클레오사이드는 안티센스 활성을 나타낸 올리고뉴클레오타이드로 도입된다(문헌[Frieden et al., Nucleic Acids Research, 2003, 21, 6365-6372]). 본 명세서에서, 이환식 뉴클레오사이드의 일반적인 설명은 이성질체 배위 둘 다를 포함한다. 특정 이환식 뉴클레오사이드(예를 들어, LNA 또는 cEt)의 위치가 본 명세서에서 예시된 실시형태에서 확인될 때, 이들은, 달리 명시되지 않는 한, β-D 배위로 존재한다.
특정 실시형태에서, 변형된 당 모이어티는 하나 이상의 비-브리징 당 치환기 및 하나 이상의 브리징 당 치환기(예를 들어, 5'-치환된 및 4'-2' 브리징된 당)를 포함한다.
특정 실시형태에서, 변형된 당 모이어티는 당 대용체이다. 이러한 특정 실시형태에서, 당 모이어티의 산소 원자는 예를 들어 황, 탄소 또는 질소 원자에 의해 대체된다. 이러한 특정 실시형태에서, 이러한 변형된 당 모이어티는 또한 본 명세서에 기재된 바와 같은 브리징 및/또는 비-브리징 치환기를 포함한다. 예를 들어, 특정 당 대용체는 4'-황 원자 및 2'-위치(예를 들어, U.S. 7,875,733(Bhat 등) 및 U.S. 7,939,677(Bhat 등) 참조) 및/또는 5' 위치에서의 치환을 포함한다.
특정 실시형태에서, 당 대용체는 5개의 원자 이외를 갖는 고리를 포함한다. 예를 들어, 특정 실시형태에서, 당 대용체는 6원의 테트라하이드로피란("THP")을 포함한다. 이러한 테트라하이드로피란은 추가로 변형되거나 치환될 수 있다. 이러한 변형된 테트라하이드로피란을 포함하는 뉴클레오사이드는 헥시톨 핵산("HNA"), 아니톨 핵산("ANA"), 만니톨 핵산("MNA")(예를 들어, 문헌[Leumann, CJ. Bioorg. & Med. Chem. 2002, 10, 841-854] 참조), 플루오로 HNA:
("F-HNA", 예를 들어, U.S. 8,088,904(Swayze 등); U.S. 8,440,803(Swayze 등); U.S. 8,796,437(Swayze 등); 및 U.S. 9,005,906(Swayze 등); F-HNA는 또한 F-THP 또는 3'-플루오로 테트라하이드로피란이라 지칭될 수 있음), 및 하기 화학식을 갖는 추가적인 변형된 THP 화합물을 포함하는 뉴클레오사이드를 포함하지만, 이들로 제한되지 않는다:
(식 중, 독립적으로, 각각의 상기 변형된 THP 뉴클레오사이드의 경우,
Bx는 핵염기 모이어티이고;
T3 및 T4는 각각 독립적으로 변형된 THP 뉴클레오사이드를 올리고뉴클레오타이드의 나머지에 연결하는 뉴클레오사이드간 연결기이거나, T3 및 T4 중 하나는 변형된 THP 뉴클레오사이드를 올리고뉴클레오타이드의 나머지에 연결하는 뉴클레오사이드간 연결기이고, T3 및 T4 중 다른 하나는 H, 하이드록실 보호기, 연결된 접합체 기, 또는 5' 또는 3'-말단 기이고;
q1, q2, q3, q4, q5, q6 및 q7는 각각 독립적으로 H, C1-C6 알킬, 치환된 C1-C6 알킬, C2-C6 알켄일, 치환된 C2-C6 알켄일, C2-C6 알킨일, 또는 치환된 C2-C6 알킨일이고;
R1 및 R2는 각각 독립적으로 수소, 할로겐, 치환된 또는 비치환된 알콕시, NJ1J2, SJ1, N3, OC(=X)J1, OC(=X)NJ1J2, NJ3C(=X)NJ1J2 및 CN(여기서, X는 O, S 또는 NJ1이고, 각각의 J1, J2 및 J3은 각각 독립적으로 H 또는 C1-C6 알킬임)로부터 선택됨).
특정 실시형태에서, q1, q2, q3, q4, q5, q6 및 q7가 각각 H인 변형된 THP 뉴클레오사이드가 제공된다. 특정 실시형태에서, q1, q2, q3, q4, q5, q6 및 q7 중 적어도 하나는 H 이외이다. 특정 실시형태에서, q1, q2, q3, q4, q5, q6 및 q7 중 적어도 하나는 메틸이다. 특정 실시형태에서, R1 및 R2 중 하나가 F인 변형된 THP 뉴클레오사이드가 제공된다. 특정 실시형태에서, R1은 F이고, R2는 H이고, 특정 실시형태에서, R1은 메톡시이고, R2는 H이고, 특정 실시형태에서, R1은 메톡시에톡시이고, R2는 H이다.
특정 실시형태에서, 당 대용체는 5개 초과의 원자 및 1개 초과의 헤테로원자를 갖는 고리를 포함한다. 예를 들어, 몰폴리노 당 모이어티를 포함하는 뉴클레오사이드 및 올리고뉴클레오타이드에서의 이의 용도가 보고되어 있다(예를 들어, 문헌[Braasch et al., Biochemistry, 2002, 41, 4503-4510] 및 U.S. 5,698,685(Summerton 등); U.S. 5,166,315(Summerton 등); U.S. 5,185,444(Summerton 등); 및 U.S. 5,034,506(Summerton 등) 참조). 본 명세서에 사용된 바와 같이, 용어 "몰폴리노"는 하기 구조를 갖는 당 대용체를 의미한다:
특정 실시형태에서, 몰폴리노는 예를 들어 상기 몰폴리노 구조로부터 다양한 치환기를 첨가 또는 변경함으로써 변형될 수 있다. 이러한 당 대용체는 본 명세서에서 "변형된 몰폴리노"라 지칭된다.
특정 실시형태에서, 당 대용체는 비환식(acyclic) 모이어티를 포함한다. 이러한 비환식 당 대용체를 포함하는 뉴클레오사이드 및 올리고뉴클레오타이드의 예는 펩타이드 핵산("PNA"), 비환식 부틸 핵산(예를 들어, 문헌[Kumar et al., Org. Biomol. Chem., 2013, 11, 5853-5865] 참조), 및 WO2011/133876(Manoharan 등)에 기재된 뉴클레오사이드 및 올리고뉴클레오타이드를 포함하지만, 이들로 제한되지 않는다.
변형된 뉴클레오사이드에서 사용될 수 있는 많은 다른 이환식 및 삼환식 당 및 당 대용체 고리 시스템은 당업계에 공지되어 있다.
2.
특정 변형된 핵염기
특정 실시형태에서, 변형된 올리고뉴클레오타이드는 비변형된 핵염기를 포함하는 하나 이상의 뉴클레오사이드를 포함한다. 특정 실시형태에서, 변형된 올리고뉴클레오타이드는 변형된 핵염기를 포함하는 하나 이상의 뉴클레오사이드를 포함한다. 특정 실시형태에서, 변형된 올리고뉴클레오타이드는, 비염기성 뉴클레오사이드라고 지칭되는, 핵염기를 포함하지 않는 하나 이상의 뉴클레오사이드를 포함한다.
특정 실시형태에서, 변형된 핵염기는 5-치환된 피리미딘, 6-아자피리미딘, 알킬 또는 알킨일 치환된 피리미딘, 알킬 치환된 퓨린, 및 N-2, N-6 및 O-6 치환된 퓨린으로부터 선택된다. 특정 실시형태에서, 변형된 핵염기는 2-아미노프로필아데닌, 5-하이드록시메틸 사이토신, 잔틴, 하이포잔틴, 2-아미노아데닌, 6-N-메틸구아닌, 6-N-메틸아데닌, 2-프로필아데닌, 2-티오유라실, 2-티오타이민 및 2-티오사이토신, 5-프로핀일(-C≡C-CH3) 유라실, 5-프로핀일사이토신, 6-아조유라실, 6-아조사이토신, 6-아조타이민, 5-리보실유라실(슈도유라실), 4-티오유라실, 8-할로, 8-아미노, 8-티올, 8-티오알킬, 8-하이드록실, 8-아자 및 다른 8-치환된 퓨린, 5-할로, 특히 5-브로모, 5-트라이플루오로메틸, 5-할로유라실, 및 5-할로사이토신, 7-메틸구아닌, 7-메틸아데닌, 2-F-아데닌, 2-아미노아데닌, 7-데아자구아닌, 7-데아자아데닌, 3-데아자구아닌, 3-데아자아데닌, 6-N-벤조일아데닌, 2-N-아이소부티릴구아닌, 4-N-벤조일사이토신, 4-N-벤조일유라실, 5-메틸 4-N-벤조일사이토신, 5-메틸 4-N-벤조일유라실, 만능 염기, 소수성 염기, 무차별 염기, 크기-연장된 염기 및 플루오린화 염기로부터 선택된다. 추가의 변형된 핵염기는 삼환식 피리미딘, 예컨대, 1,3-다이아자페녹사진-2-온, 1,3-다이아자페노티아진-2-온 및 9-(2-아미노에톡시)-1,3-다이아자페녹사진-2-온(G-클램프)을 포함한다. 변형된 핵염기는 퓨린 또는 피리미딘 염기가 다른 헤테로사이클에 의해 대체된 것, 예를 들어 7-데아자-아데닌, 7-데아자구아노신, 2-아미노피리딘 및 2-피리돈을 또한 포함할 수 있다. 추가의 핵염기는 U.S. 3,687,808(Merigan 등)에 개시된 것, 문헌[The Concise Encyclopedia Of Polymer Science And Engineering, Kroschwitz, J.I., Ed., John Wiley & Sons, 1990, 858-859; Englisch et al., Angewandte Chemie, International Edition, 1991, 30, 613; Sanghvi, Y.S., Chapter 15, Antisense Research and Applications, Crooke, S.T. and Lebleu, B., Eds., CRC Press, 1993, 273-288]에 개시된 것; 및 문헌[Chapters 6 및 15, Antisense Drug Technology, Crooke S.T., Ed., CRC Press, 2008, 163-166 및 442-443]에 개시된 것을 포함한다.
특정 상기 기재된 변형된 핵염기, 및 다른 변형된 핵염기의 제조를 교시하는 공보는, 제한 없이, US2003/0158403(Manoharan 등); US2003/0175906(Manoharan 등); U.S. 4,845,205(Dinh 등); U.S. 5,130,302(Spielvogel 등); U.S. 5,134,066(Rogers 등); U.S. 5,175,273(Bischofberger 등); U.S. 5,367,066(Urdea 등); U.S. 5,432,272(Benner 등); U.S. 5,434,257(Matteucci 등); U.S. 5,457,187(Gmeiner 등); U.S. 5,459,255(Cook 등); U.S. 5,484,908(Froehler 등); U.S. 5,502,177(Matteucci 등); U.S. 5,525,711(Hawkins 등); U.S. 5,552,540(Haralambidis 등); U.S. 5,587,469(Cook 등); U.S. 5,594,121(Froehler 등); U.S. 5,596,091(Switzer 등); U.S. 5,614,617(Cook 등); U.S. 5,645,985(Froehler 등); U.S. 5,681,941(Cook 등); U.S. 5,811,534(Cook 등); U.S. 5,750,692(Cook 등); U.S. 5,948,903(Cook 등); U.S. 5,587,470(Cook 등); U.S. 5,457,191(Cook 등); U.S. 5,763,588(Matteucci 등); U.S. 5,830,653(Froehler 등); U.S. 5,808,027(Cook 등); 6,166,199(Cook 등); 및 U.S. 6,005,096(Matteucci 등)을 포함한다.
3.
특정 변형된 뉴클레오사이드간 링키지
특정 실시형태에서, 변형된 올리고뉴클레오타이드의 뉴클레오사이드는 임의의 뉴클레오사이드간 링키지를 이용하여 함께 연결될 수 있다. 뉴클레오사이드간 연결기의 2개의 주요 종류는 인 원자의 존재 또는 부재에 의해 정의된다. 대표적인 인 함유 뉴클레오사이드간 링키지는 포스포다이에스터 결합("P=O")(비변형된 또는 자연 발생 링키지라고도 지칭함), 포스포트라이에스터, 메틸포스포네이트, 포스포르아미데이트, 및 포스포로티오에이트("P=S") 및 포스포로다이티오에이트("HS-P=S")를 함유하는 포스페이트를 포함하지만, 이들로 제한되지 않는다. 대표적인 인 비함유 뉴클레오사이드간 연결기는 메틸렌메틸이미노(-CH2-N(CH3)-O-CH2-), 티오다이에스터, 티오노카바메이트(-O-C(=O)(NH)-S-); 실록산(-O-SiH2-O-); 및 N,N'-다이메틸하이드라진(-CH2-N(CH3)-N(CH3)-)을 포함하지만, 이들로 제한되지 않는다. 자연 발생 포스페이트 링키지와 비교하여, 변형된 뉴클레오사이드간 링키지는 올리고뉴클레오타이드의 뉴클레아제 내성을 변경, 통상적으로 증가시키도록 이용될 수 있다. 특정 실시형태에서, 카이럴 탄소를 갖는 뉴클레오사이드간 링키지는 라세미 혼합물 또는 별개의 거울상이성질체로서 제조될 수 있다. 인 함유 및 인 비함유 뉴클레오사이드간 링키지의 제조의 방법은 당업자에게 널리 공지되어 있다.
카이럴 중심을 갖는 대표적인 뉴클레오사이드간 링키지는 알킬포스포네이트 및 포스포로티오에이트를 포함하지만, 이들로 제한되지 않는다. 카이럴 중심을 갖는 뉴클레오사이드간 링키지를 포함하는 변형된 올리고뉴클레오타이드는 특정 입체화학 배위에서 입체무작위 뉴클레오사이드간 링키지를 포함하는 변형된 올리고뉴클레오타이드의 집단으로서 또는 포스포로티오에이트 연결을 포함하는 변형된 올리고뉴클레오타이드의 집단으로서 제조될 수 있다. 특정 실시형태에서, 변형된 올리고뉴클레오타이드의 집단은 모든 포스포로티오에이트 뉴클레오사이드간 링키지가 입체무작위인 포스포로티오에이트 뉴클레오사이드간 링키지를 포함한다. 이러한 변형된 올리고뉴클레오타이드는 각각의 포스포로티오에이트 연결의 입체화학 배위의 무작위 선택을 발생시키는 합성 방법을 이용하여 생성될 수 있다. 그럼에도 불구하고, 당업자에 의해 널리 이해되는 바와 같이 각각의 개별 올리고뉴클레오타이드 분자의 각각의 개별 포스포로티오에이트는 정의된 입체배위를 갖는다. 특정 실시형태에서, 변형된 올리고뉴클레오타이드의 집단은 특정 독립적으로 선택된 입체화학 배위에서 하나 이상의 특정 포스포로티오에이트 뉴클레오사이드간 링키지를 포함하는 변형된 올리고뉴클레오타이드가 풍부하다. 특정 실시형태에서, 특정 포스포로티오에이트 연결의 특정 배위는 집단에서 분자의 적어도 65%로 존재한다. 특정 실시형태에서, 특정 포스포로티오에이트 연결의 특정 배위는 집단에서 분자의 적어도 70%로 존재한다. 특정 실시형태에서, 특정 포스포로티오에이트 연결의 특정 배위는 집단에서 분자의 적어도 80%로 존재한다. 특정 실시형태에서, 특정 포스포로티오에이트 연결의 특정 배위는 집단에서 분자의 적어도 90%로 존재한다. 특정 실시형태에서, 특정 포스포로티오에이트 연결의 특정 배위는 집단에서 분자의 적어도 99%로 존재한다. 변형된 올리고뉴클레오타이드의 이러한 카이럴적으로 풍부한 집단은 당해 분야에 공지된 합성 방법, 예를 들어 문헌[Oka et al., JACS 125, 8307 (2003), Wan et al. Nuc. Acid. Res. 42, 13456 (2014)] 및 WO 2017/015555에 기재된 방법을 이용하여 생성될 수 있다. 특정 실시형태에서, 변형된 올리고뉴클레오타이드의 집단은 (Sp) 배위의 적어도 하나의 표시된 포스포로티오에이트를 갖는 변형된 올리고뉴클레오타이드가 풍부하다. 특정 실시형태에서, 변형된 올리고뉴클레오타이드의 집단은 (Rp) 배위의 적어도 하나의 포스포로티오에이트를 갖는 변형된 올리고뉴클레오타이드가 풍부하다. 특정 실시형태에서, (Rp) 및/또는(Sp) 포스포로티오에이트를 포함하는 변형된 올리고뉴클레오타이드는 각각 하기 화학식(여기서, "B"는 핵염기를 나타냄) 중 하나 이상을 포함한다:
달리 표시되지 않는 한, 본 명세서에 기재된 변형된 올리고뉴클레오타이드의 카이럴 뉴클레오사이드간 링키지는 입체무작위 또는 특정 입체화학 배위로 존재할 수 있다.
중성 뉴클레오사이드간 링키지는, 제한 없이, 포스포트라이에스터, 메틸포스포네이트, MMI(3'-CH2-N(CH3)-O-5'), 아마이드-3(3'-CH2-C(=O)-N(H)-5'), 아마이드-4(3'-CH2-N(H)-C(=O)-5'), 폼아세탈(3'-O-CH2-O-5'), 메톡시프로필 및 티오폼아세탈(3'-S-CH2-O-5')을 포함한다. 추가의 중성 뉴클레오사이드간 연결은 실록산(다이알킬실록산), 카복실레이트 에스터, 카복스아마이드, 설파이드, 설포네이트 에스터 및 아마이드를 포함하는 비이온성 연결을 포함한다(예를 들어, 문헌[Carbohydrate Modifications in Antisense Research; Y.S. Sanghvi and P.D. Cook, Eds., ACS Symposium Series 580; Chapters 3 및 4, 40-65] 참조). 추가의 중성 뉴클레오사이드간 링키지는 혼합된 N, O, S 및 CH2 성분 부분을 포함하는 비이온성 연결을 포함한다.
B.
특정 모티프
특정 실시형태에서, 변형된 올리고뉴클레오타이드는 변형된 당 모이어티를 포함하는 하나 이상의 변형된 뉴클레오사이드를 포함한다. 특정 실시형태에서, 변형된 올리고뉴클레오타이드는 변형된 핵염기를 포함하는 하나 이상의 변형된 뉴클레오사이드를 포함한다. 특정 실시형태에서, 변형된 올리고뉴클레오타이드는 하나 이상의 변형된 뉴클레오사이드간 링키지를 포함한다. 이러한 실시형태에서, 변형된 올리고뉴클레오타이드의 변형된, 비변형된, 및 다르게 변형된 당 모이어티, 핵염기, 및/또는 뉴클레오사이드간 링키지는 패턴 또는 모티프를 한정한다. 특정 실시형태에서, 당 모이어티, 핵염기, 및 뉴클레오사이드간 링키지의 패턴은 서로에 각각 독립적이다. 따라서, 변형된 올리고뉴클레오타이드는 이의 당 모티프, 핵염기 모티프 및/또는 뉴클레오사이드간 링키지 모티프에 의해 기재될 수 있다(본 명세서에 사용된 바와 같이, 핵염기 모티프는 핵염기의 서열에 독립적인 핵염기에 대한 변형을 기재한다).
1.
특정 당 모티프
특정 실시형태에서, 올리고뉴클레오타이드는 한정된 패턴 또는 당 모티프에서 올리고뉴클레오타이드 또는 이의 영역을 따라 배열된 변형된 당 및/또는 비변형된 당 모이어티의 하나 이상의 유형을 포함한다. 특정 경우에, 이러한 당 모티프는 본 명세서에 기재된 임의의 당 변형을 포함하지만, 이들로 제한되지 않는다.
특정 실시형태에서, 변형된 올리고뉴클레오타이드는 2개의 외부 영역 또는 "윙" 및 중심 또는 내부 영역 또는 "갭"에 의해 한정된 갭머 모티프를 갖는 영역을 포함하고 이것으로 이루어진다. 갭머 모티프의 3개의 영역(5'-윙, 갭 및 3'-윙)은 뉴클레오사이드의 인접한 서열을 형성하고, 여기서 각각의 윙의 뉴클레오사이드의 당 모이어티의 적어도 일부는 갭의 뉴클레오사이드의 당 모이어티의 적어도 일부와 다르다. 구체적으로, 적어도 갭에 가장 가까운 각각의 윙(5'-윙의 3'-가장 가까운 뉴클레오사이드 및 3'-윙의 5'-가장 가까운 뉴클레오사이드)의 뉴클레오사이드의 당 모이어티는 이웃하는 갭 뉴클레오사이드의 당 모이어티와 달라서, 윙 및 갭 사이의 경계(즉, 윙/갭 접합부)를 한정한다. 특정 실시형태에서, 갭 내의 당 모이어티는 서로 동일하다. 특정 실시형태에서, 갭은 갭의 하나 이상의 다른 뉴클레오사이드의 당 모이어티와 다른 당 모이어티를 갖는 하나 이상의 뉴클레오사이드를 포함한다. 특정 실시형태에서, 2개의 윙의 당 모티프는 서로 동일하다(대칭 갭머). 특정 실시형태에서, 5'-윙의 당 모티프는 3'-윙의 당 모티프와 다르다(비대칭 갭머).
특정 실시형태에서, 갭머의 윙은 1개 내지 5개의 뉴클레오사이드를 포함한다. 특정 실시형태에서, 갭머의 각각의 윙의 각각의 뉴클레오사이드는 변형된 뉴클레오사이드이다. 특정 실시형태에서, 갭머의 각각의 윙 중 적어도 하나의 뉴클레오사이드는 변형된 뉴클레오사이드이다. 특정 실시형태에서, 갭머의 각각의 윙 중 적어도 2개의 뉴클레오사이드는 변형된 뉴클레오사이드이다. 특정 실시형태에서, 갭머의 각각의 윙 중 적어도 3개의 뉴클레오사이드는 변형된 뉴클레오사이드이다. 특정 실시형태에서, 갭머의 각각의 윙 중 적어도 4개의 뉴클레오사이드는 변형된 뉴클레오사이드이다.
특정 실시형태에서, 갭머의 갭은 7개 내지 12개의 뉴클레오사이드를 포함한다. 특정 실시형태에서, 갭머의 갭의 각각의 뉴클레오사이드는 비변형된 2'-데옥시뉴클레오사이드이다. 특정 실시형태에서, 갭머의 갭 중 적어도 하나의 뉴클레오사이드는 변형된 뉴클레오사이드이다.
특정 실시형태에서, 갭머는 데옥시 갭머이다. 특정 실시형태에서, 각각의 날개/갭 연접부의 갭 측에서의 뉴클레오사이드는 비변형된 2'-데옥시뉴클레오사이드이고, 각각의 날개/갭 연접부의 날개 측에서의 뉴클레오사이드는 변형된 뉴클레오사이드이다. 특정 실시형태에서, 갭의 각각의 뉴클레오사이드는 비변형된 2'-데옥시뉴클레오사이드이다. 특정 실시형태에서, 갭머의 각각의 윙의 각각의 뉴클레오사이드는 변형된 뉴클레오사이드이다.
특정 실시형태에서, 변형된 올리고뉴클레오타이드는 완전히 변형된 당 모티프를 갖는 영역을 포함하거나 이것으로 이루어진다. 이러한 실시형태에서, 변형된 올리고뉴클레오타이드의 완전히 변형된 영역의 각각의 뉴클레오사이드는 변형된 당 모이어티를 포함한다. 특정 실시형태에서, 전체 변형된 올리고뉴클레오타이드의 각각의 뉴클레오사이드는 변형된 당 모이어티를 포함한다. 특정 실시형태에서, 변형된 올리고뉴클레오타이드는 완전히 변형된 당 모티프를 갖는 영역을 포함하거나 이것으로 이루어지고, 완전히 변형된 영역 내의 각각의 뉴클레오사이드는 균일하게 변형된 당 모티프라고 본 명세서에서 지칭되는 동일한 변형된 당 모이어티를 포함한다. 특정 실시형태에서, 완전히 변형된 올리고뉴클레오타이드는 균일하게 변형된 올리고뉴클레오타이드이다. 특정 실시형태에서, 균일하게 변형된 것의 각각의 뉴클레오사이드는 동일한 2'-변형을 포함한다.
여기서, 갭머의 3개의 영역의 길이(뉴클레오사이드의 수)는 표시를 이용하여 제공될 수 있다: [5'-윙에서의 뉴클레오사이드의 수] - [갭에서의 뉴클레오사이드의 수] - [3'-윙에서의 뉴클레오사이드의 수]. 따라서, 5-10-5 갭머는 각각의 윙에서 5개의 연결된 뉴클레오사이드 및 갭에서 10개의 연결된 뉴클레오사이드로 이루어진다. 이러한 명명법은 특정한 변형 앞에 존재하는 경우, 그 변형은 각각의 윙의 각각의 당 모이어티에서의 변형이고, 갭 뉴클레오사이드는 비변형된 데옥시뉴클레오사이드 당을 포함한다. 따라서, 5-10-5 MOE 갭머는 5'-윙에서 5개의 연결된 MOE 변형된 뉴클레오사이드, 갭에서 10개의 연결된 데옥시뉴클레오사이드 및 3'-윙에서 5개의 연결된 MOE 뉴클레오사이드로 이루어진다.
특정 실시형태에서, 변형된 올리고뉴클레오타이드는 5-10-5 MOE 갭머이다. 특정 실시형태에서, 변형된 올리고뉴클레오타이드는 3-10-3 BNA 갭머이다. 특정 실시형태에서, 변형된 올리고뉴클레오타이드는 3-10-3 cEt 갭머이다. 특정 실시형태에서, 변형된 올리고뉴클레오타이드는 3-10-3 LNA 갭머이다.
2.
특정 핵염기 모티프
특정 실시형태에서, 올리고뉴클레오타이드는 한정된 패턴 또는 모티프에서 올리고뉴클레오타이드 또는 이의 영역을 따라 배열된 변형된 및/또는 비변형된 핵염기를 포함한다. 특정 실시형태에서, 각각의 핵염기는 변형된다. 특정 실시형태에서, 핵염기 중 어느 것도 변형되지 않는다. 특정 실시형태에서, 각각의 퓨린 또는 각각의 피리미딘은 변형된다. 특정 실시형태에서, 각각의 아데닌은 변형된다. 특정 실시형태에서, 각각의 구아닌은 변형된다. 특정 실시형태에서, 각각의 타이민은 변형된다. 특정 실시형태에서, 각각의 유라실은 변형된다. 특정 실시형태에서, 각각의 사이토신은 변형된다. 특정 실시형태에서, 변형된 올리고뉴클레오타이드 내의 사이토신 핵염기의 일부 또는 전부는 5-메틸 사이토신이다. 특정 실시형태에서, 사이토신 핵염기의 전부는 5-메틸 사이토신이고, 변형된 올리고뉴클레오타이드의 다른 핵염기의 전부는 비변형된 핵염기이다.
특정 실시형태에서, 변형된 올리고뉴클레오타이드는 변형된 핵염기의 블록을 포함한다. 이러한 특정 실시형태에서, 블록은 올리고뉴클레오타이드의 3'-단부에 존재한다. 특정 실시형태에서, 블록은 올리고뉴클레오타이드의 3'-단부의 3개의 뉴클레오사이드 내에 존재한다. 특정 실시형태에서, 블록은 올리고뉴클레오타이드의 5'-단부에 존재한다. 특정 실시형태에서, 블록은 올리고뉴클레오타이드의 5'-단부의 3개의 뉴클레오사이드 내에 존재한다.
특정 실시형태에서, 갭머 모티프를 포함하는 올리고뉴클레오타이드는 변형된 핵염기를 포함하는 뉴클레오사이드를 포함한다. 이러한 특정 실시형태에서, 변형된 핵염기를 포함하는 1개의 뉴클레오사이드는 갭머 모티프를 갖는 올리고뉴클레오타이드의 중심 갭에 존재한다. 이러한 특정 실시형태에서, 상기 뉴클레오사이드의 당 모이어티는 2'-데옥시리보실 모이어티이다. 특정 실시형태에서, 변형된 핵염기는 2-티오피리미딘 및 5-프로핀피리미딘으로부터 선택된다.
3.
특정 뉴클레오사이드간 링키지 모티프
특정 실시형태에서, 올리고뉴클레오타이드는 한정된 패턴 또는 모티프에서 올리고뉴클레오타이드 또는 이의 영역을 따라 배열된 변형된 및/또는 비변형된 뉴클레오사이드간 링키지를 포함한다. 특정 실시형태에서, 각각의 뉴클레오사이드간 연결기는 포스포다이에스터 뉴클레오사이드간 링키지(P=O)이다. 특정 실시형태에서, 변형된 올리고뉴클레오타이드의 각각의 뉴클레오사이드간 연결기는 포스포로티오에이트 뉴클레오사이드간 링키지(P=S)이다. 특정 실시형태에서, 변형된 올리고뉴클레오타이드의 각각의 뉴클레오사이드간 링키지는 포스포로티오에이트 뉴클레오사이드간 링키지 및 포스포다이에스터 뉴클레오사이드간 링키지로부터 독립적으로 선택된다. 특정 실시형태에서, 각각의 포스포로티오에이트 뉴클레오사이드간 링키지는 입체무작위 포스포로티오에이트, (Sp) 포스포로티오에이트 및 (Rp) 포스포로티오에이트로부터 독립적으로 선택된다. 특정 실시형태에서, 변형된 올리고뉴클레오타이드의 당 모티프는 갭머이고, 갭 내의 뉴클레오사이드간 링키지는 모두 변형된다. 이러한 특정 실시형태에서, 윙에서의 뉴클레오사이드간 링키지의 일부 또는 전부는 비변형된 포스포다이에스터 뉴클레오사이드간 링키지이다. 특정 실시형태에서, 말단 뉴클레오사이드간 링키지는 변형된다. 특정 실시형태에서, 변형된 올리고뉴클레오타이드의 당 모티프는 갭머이고, 뉴클레오사이드간 링키지 모티프는 적어도 하나의 윙에서 적어도 하나의 포스포다이에스터 뉴클레오사이드간 링키지를 포함하고, 적어도 하나의 포스포다이에스터 연결은 말단 뉴클레오사이드간 링키지가 아니고, 나머지 뉴클레오사이드간 링키지는 포스포로티오에이트 뉴클레오사이드간 링키지이다. 이러한 특정 실시형태에서, 포스포로티오에이트 연결의 전부는 입체무작위이다. 특정 실시형태에서, 윙에서의 포스포로티오에이트 연결의 전부는 (Sp) 포스포로티오에이트이고, 갭은 적어도 하나의 Sp, Sp, Rp 모티프를 포함한다. 특정 실시형태에서, 변형된 올리고뉴클레오타이드의 집단은 이러한 뉴클레오사이드간 링키지 모티프를 포함하는 변형된 올리고뉴클레오타이드가 풍부하다.
C.
특정 길이
활성을 제거하지 않으면서 올리고뉴클레오타이드의 길이를 증가시키거나 감소시킬 수 있다. 예를 들어, Woolf 등의 문헌(Proc. Natl. Acad. Sci. USA 89:7305-7309, 1992)에서, 일련의 올리고뉴클레오타이드 13개 내지 25개 핵염기 길이는 난모세포 주사 모델에서 표적 RNA의 절단을 유도하는 이의 능력에 대해 시험되었다. 올리고뉴클레오타이드의 단부 근처의 8개 또는 11개의 미스매치 염기를 갖는 올리고뉴클레오타이드 25 핵염기 길이는 미스매치를 함유하지 않는 올리고뉴클레오타이드보다 더 적은 정도이긴 하지만 표적 RNA의 특이적 절단을 지시할 수 있다. 유사하게, 표적 특이적 절단은 13개의 핵염기 올리고뉴클레오타이드, 예를 들어 1개 또는 3개의 미스매치를 갖는 것을 사용하여 달성되었다.
특정 실시형태에서, 올리고뉴클레오타이드(변형된 올리고뉴클레오타이드 포함)는 길이의 임의의 다양한 범위를 가질 수 있다. 특정 실시형태에서, 올리고뉴클레오타이드는 X개 내지 Y개의 연결된 뉴클레오사이드(여기서, X는 범위에서 뉴클레오사이드의 가장 작은 수를 나타내고, Y는 범위에서 뉴클레오사이드의 가장 큰 수를 나타냄)로 이루어진다. 이러한 특정 실시형태에서, X 및 Y는 각각 독립적으로 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 및 50으로부터 선택되고; 단 X≤Y이다. 예를 들어, 특정 실시형태에서, 올리고뉴클레오타이드는 12 내지 13, 12 내지 14, 12 내지 15, 12 내지 16, 12 내지 17, 12 내지 18, 12 내지 19, 12 내지 20, 12 내지 21, 12 내지 22, 12 내지 23, 12 내지 24, 12 내지 25, 12 내지 26, 12 내지 27, 12 내지 28, 12 내지 29, 12 내지 30, 13 내지 14, 13 내지 15, 13 내지 16, 13 내지 17, 13 내지 18, 13 내지 19, 13 내지 20, 13 내지 21, 13 내지 22, 13 내지 23, 13 내지 24, 13 내지 25, 13 내지 26, 13 내지 27, 13 내지 28, 13 내지 29, 13 내지 30, 14 내지 15, 14 내지 16, 14 내지 17, 14 내지 18, 14 내지 19, 14 내지 20, 14 내지 21, 14 내지 22, 14 내지 23, 14 내지 24, 14 내지 25, 14 내지 26, 14 내지 27, 14 내지 28, 14 내지 29, 14 내지 30, 15 내지 16, 15 내지 17, 15 내지 18, 15 내지 19, 15 내지 20, 15 내지 21, 15 내지 22, 15 내지 23, 15 내지 24, 15 내지 25, 15 내지 26, 15 내지 27, 15 내지 28, 15 내지 29, 15 내지 30, 16 내지 17, 16 내지 18, 16 내지 19, 16 내지 20, 16 내지 21, 16 내지 22, 16 내지 23, 16 내지 24, 16 내지 25, 16 내지 26, 16 내지 27, 16 내지 28, 16 내지 29, 16 내지 30, 17 내지 18, 17 내지 19, 17 내지 20, 17 내지 21, 17 내지 22, 17 내지 23, 17 내지 24, 17 내지 25, 17 내지 26, 17 내지 27, 17 내지 28, 17 내지 29, 17 내지 30, 18 내지 19, 18 내지 20, 18 내지 21, 18 내지 22, 18 내지 23, 18 내지 24, 18 내지 25, 18 내지 26, 18 내지 27, 18 내지 28, 18 내지 29, 18 내지 30, 19 내지 20, 19 내지 21, 19 내지 22, 19 내지 23, 19 내지 24, 19 내지 25, 19 내지 26, 19 내지 29, 19 내지 28, 19 내지 29, 19 내지 30, 20 내지 21, 20 내지 22, 20 내지 23, 20 내지 24, 20 내지 25, 20 내지 26, 20 내지 27, 20 내지 28, 20 내지 29, 20 내지 30, 21 내지 22, 21 내지 23, 21 내지 24, 21 내지 25, 21 내지 26, 21 내지 27, 21 내지 28, 21 내지 29, 21 내지 30, 22 내지 23, 22 내지 24, 22 내지 25, 22 내지 26, 22 내지 27, 22 내지 28, 22 내지 29, 22 내지 30, 23 내지 24, 23 내지 25, 23 내지 26, 23 내지 27, 23 내지 28, 23 내지 29, 23 내지 30, 24 내지 25, 24 내지 26, 24 내지 27, 24 내지 28, 24 내지 29, 24 내지 30, 25 내지 26, 25 내지 27, 25 내지 28, 25 내지 29, 25 내지 30, 26 내지 27, 26 내지 28, 26 내지 29, 26 내지 30, 27 내지 28, 27 내지 29, 27 내지 30, 28 내지 29, 28 내지 30, 또는 29 내지 30개의 연결된 뉴클레오사이드로 이루어진다.
D.
특정 변형된 올리고뉴클레오타이드
특정 실시형태에서, 상기 변형(당, 핵염기, 뉴클레오사이드간 링키지)은 변형된 올리고뉴클레오타이드에 도입된다. 특정 실시형태에서, 변형된 올리고뉴클레오타이드는 이의 변형 모티프 및 전체 길이를 특징으로 한다. 특정 실시형태에서, 이러한 파리미터는 각각 서로 독립적이다. 따라서, 달리 표시되지 않는 한, 갭머 당 모티프를 갖는 올리고뉴클레오타이드의 각각의 뉴클레오사이드간 링키지는 변형되거나 비변형될 수 있고, 당 변형의 갭머 변형 패턴을 따르거나 따르지 않을 수 있다. 예를 들어, 당 갭머의 윙 영역 내의 뉴클레오사이드간 링키지는 서로 동일하거나 상이할 수 있고, 당 모티프의 갭 영역의 뉴클레오사이드간 링키지로부터 동일하거나 상이할 수 있다. 마찬가지로, 이러한 당 갭머 올리고뉴클레오타이드는 당 변형의 갭머 패턴과 독립적인 하나 이상의 변형된 핵염기를 포함할 수 있다. 달리 표시되지 않는 한, 모든 변형은 핵염기 서열에 독립적이다.
E.
변형된 올리고뉴클레오타이드의 특정 집단
집단의 변형된 올리고뉴클레오타이드의 전부가 동일한 분자식을 갖는 변형된 올리고뉴클레오타이드의 집단은 입체무작위 집단 또는 카이럴적으로 풍부한 집단일 수 있다. 모든 변형된 올리고뉴클레오타이드의 모든 카이럴 중심은 입체무작위 집단에서 입체무작위이다. 카이럴적으로 풍부한 집단에서, 적어도 하나의 특정 카이럴 중심은 집단의 변형된 올리고뉴클레오타이드에서 입체무작위가 아니다. 특정 실시형태에서, 카이럴적으로 풍부한 집단의 변형된 올리고뉴클레오타이드는 β-D 리보실 당 모이어티가 풍부하고, 모든 포스포로티오에이트 뉴클레오사이드간 링키지는 입체무작위이다. 특정 실시형태에서, 카이럴적으로 풍부한 집단의 변형된 올리고뉴클레오타이드는 특정 입체화학 배위에서 β-D 리보실 당 모이어티 및 적어도 하나의, 특정 포스포로티오에이트 뉴클레오사이드간 링키지 둘 다가 풍부하다.
F.
핵염기 서열
특정 실시형태에서, 올리고뉴클레오타이드(비변형된 또는 변형된 올리고뉴클레오타이드)는 이의 핵염기 서열에 의해 추가로 기재된다. 특정 실시형태에서 올리고뉴클레오타이드는 제2 올리고뉴클레오타이드 또는 확인된 기준 핵산, 예컨대, 표적 핵산에 상보성인 핵염기 서열을 갖는다. 이러한 특정 실시형태에서, 올리고뉴클레오타이드의 영역은 제2 올리고뉴클레오타이드 또는 확인된 기준 핵산, 예컨대, 표적 핵산에 상보성인 핵염기 서열을 갖는다. 특정 실시형태에서, 올리고뉴클레오타이드의 영역 또는 전체 길이의 핵염기 서열은 제2 올리고뉴클레오타이드 또는 핵산, 예컨대, 표적 핵산과 적어도 50%, 적어도 60%, 적어도 70%, 적어도 80%, 적어도 85%, 적어도 90%, 적어도 95% 또는 100% 상보성이다.
I.
특정 올리고머 화합물
특정 실시형태에서, 본 발명에는 올리고뉴클레오타이드(변형된 또는 비변형된) 및 임의로 하나 이상의 접합체 기 및/또는 말단 기로 이루어진 올리고머 화합물을 제공된다. 접합체 기는 하나 이상의 접합체 모이어티 및 접합체 모이어티를 올리고뉴클레오타이드에 연결하는 접합체 링커로 이루어진다. 접합체 기는 올리고뉴클레오타이드의 어느 한 말단 또는 양 단부에 및/또는 임의의 내부 위치에서 부착될 수 있다. 특정 실시형태에서, 접합체 기는 변형된 올리고뉴클레오타이드의 뉴클레오사이드의 2'-위치에 부착된다. 특정 실시형태에서, 올리고뉴클레오타이드의 어느 한 말단 또는 양 말단에 부착된 접합체 기는 말단 기이다. 이러한 특정 실시형태에서, 접합체 기 또는 말단 기는 올리고뉴클레오타이드의 3' 및/또는 5'-단부에서 부착된다. 이러한 특정 실시형태에서, 접합체 기(또는 말단 기)는 올리고뉴클레오타이드의 3'-단부에서 부착된다. 특정 실시형태에서, 접합체 기는 올리고뉴클레오타이드의 3'-단부의 근처에서 부착된다. 특정 실시형태에서, 접합체 기(또는 말단 기)는 올리고뉴클레오타이드의 5'-단부에서 부착된다. 특정 실시형태에서, 접합체 기는 올리고뉴클레오타이드의 5'-단부의 근처에서 부착된다.
말단 기의 예는 접합체 기, 캡핑 기, 포스페이트 모이어티, 보호기, 변형된 또는 비변형된 뉴클레오사이드, 및 독립적으로 변형된 또는 비변형된 2개 이상의 뉴클레오사이드를 포함하지만, 이들로 제한되지 않는다.
A.
특정 접합체 기
특정 실시형태에서, 올리고뉴클레오타이드는 하나 이상의 접합체 기에 공유 부착된다. 특정 실시형태에서, 접합체 기는 약력학, 약동학, 안정성, 결합, 흡수, 조직 분포, 세포 분포, 세포 흡수, 전하 및 청소율(이들로 제한되지 않음)을 포함하는 부착된 올리고뉴클레오타이드의 하나 이상의 특성을 변경시킨다. 특정 실시형태에서, 접합체 기는 부착된 올리고뉴클레오타이드, 예를 들어 올리고뉴클레오타이드의 부착이 가능하게 하는 형광단 또는 리포터 기에 새로운 특성을 부여한다. 특정 접합체 기 및 접합체 모이어티, 예를 들어 콜레스테롤 모이어티(문헌[Letsinger et al., Proc. Natl. Acad. Sci. USA, 1989, 86, 6553-6556]), 콜산(문헌[Manoharan et al., Bioorg. Med. Chem. Lett., 1994, 4, 1053-1060]), 티오에터, 예를 들어, 헥실-S-트리틸티올(문헌[Manoharan et al., Ann. N.Y. Acad. Sci., 1992, 660, 306-309; Manoharan et al., Bioorg. Med. Chem. Lett., 1993, 3, 2765-2770]), 티오콜레스테롤(문헌[Oberhauser et al., Nucl. Acids Res., 1992, 20, 533-538]), 지방족 쇄, 예를 들어 도데칸-다이올 또는 운데실 잔기(문헌[Saison-Behmoaras et al., EMBO J., 1991, 10, 1111-1118; Kabanov et al., FEBS Lett., 1990, 259, 327-330; Svinarchuk et al., Biochimie, 1993, 75, 49-54]), 인지질, 예를 들어, 다이-헥사데실-rac-글리세롤 또는 트라이에틸-암모늄 1,2-다이-O-헥사데실-rac-글리세로-3-H-포스포네이트(문헌[Manoharan et al., Tetrahedron Lett., 1995, 36, 3651-3654; Shea et al., Nucl. Acids Res., 1990, 18, 3777-3783]), 폴리아민 또는 폴리에틸렌 글리콜 쇄(문헌[Manoharan et al., Nucleosides & Nucleotides, 1995, 14, 969-973]), 또는 아다만탄 아세트산 팔미틸 모이어티(문헌[Mishra et al., Biochim. Biophys. Acta, 1995, 1264, 229-237]), 옥타데실아민 또는 헥실아미노-카보닐-옥시콜레스테롤 모이어티(문헌[Crooke et al., J. Pharmacol. Exp. Ther., 1996, 277, 923-937]), 토코페롤기(문헌[Nishina et al., Molecular Therapy 핵산s, 2015, 4, e220; 및 Nishina et al., Molecular Therapy, 2008, 16, 734-740]), 또는 GalNAc 클러스터(예를 들어, WO2014/179620)가 이미 기재되어 있다.
1.
접합체 모이어티
접합체 모이어티는, 제한 없이, 인터칼레이터(intercalator), 리포터 분자, 폴리아민, 폴리아마이드, 펩타이드, 탄수화물, 비타민 모이어티, 폴리에틸렌 글리콜, 티오에터, 폴리에터, 콜레스테롤, 티오콜레스테롤, 콜산 모이어티, 폴레이트, 지질, 인지질, 바이오틴, 페나진, 페난트리딘, 안트라퀴논, 아다만탄, 아크리딘, 플루오레세인, 로다민, 쿠마린, 형광단 및 염료를 포함한다.
특정 실시형태에서, 접합체 모이어티는 활성 약물 물질, 예를 들어 아스피린, 와파린, 페닐부타존, 이부프로펜, 수프로펜, 펜-부펜, 케토프로펜, (S)-(+)-프라노프로펜, 카르프로펜, 단실사르코신, 2,3,5-트라이아이오도벤조산, 핑골리모드, 플루페남산, 폴린산, 벤조티아디아지드, 클로로티아자이드, 다이아제핀, 인도-메티신, 바비튜레이트, 세팔로스포린, 설파 약물, 항당뇨병제, 항박테리아제 또는 항생제를 포함한다.
2.
접합체 링커
접합체 모이어티는 접합체 링커를 통해 올리고뉴클레오타이드에 부착된다. 특정 올리고머 화합물에서, 접합체 링커는 단일 화학 결합이다(즉, 접합체 모이어티는 단일 결합을 통해 올리고뉴클레오타이드에 직접적으로 부착된다). 특정 실시형태에서, 접합체 링커는 사슬 구조, 예컨대, 하이드로카빌 쇄, 또는 반복 단위, 예컨대, 에틸렌 글리콜, 뉴클레오사이드 또는 아미노산 단위의 올리고머를 포함한다.
특정 실시형태에서, 접합체 링커는 알킬, 아미노, 옥소, 아마이드, 다이설파이드, 폴리에틸렌 글리콜, 에터, 티오에터 및 하이드록실아미노로부터 선택된 하나 이상의 기를 포함한다. 이러한 특정 실시형태에서, 접합체 링커는 알킬, 아미노, 옥소, 아마이드 및 에터기로부터 선택된 기를 포함한다. 특정 실시형태에서, 접합체 링커는 알킬 및 아마이드기로부터 선택된 기를 포함한다. 특정 실시형태에서, 접합체 링커는 알킬 및 에터기로부터 선택된 기를 포함한다. 특정 실시형태에서, 접합체 링커는 적어도 하나의 인 모이어티를 포함한다. 특정 실시형태에서, 접합체 링커는 적어도 하나의 포스페이트기를 포함한다. 특정 실시형태에서, 접합체 링커는 적어도 하나의 중성 연결기를 포함한다.
특정 실시형태에서, 상기에 기재된 접합체 링커를 포함하는 접합체 링커는 이작용성 연결 모이어티, 예를 들어 모 화합물에 접합체 기를 부착하기에 유용한 것으로 당업계에 공지된 것, 예컨대, 본 명세서에 제공된 올리고뉴클레오타이드이다. 일반적으로, 이작용성 연결 모이어티는 적어도 2개의 작용기를 포함한다. 작용기의 하나는 모 화합물에서 특정 부위에 결합하도록 선택되고, 다른 것은 접합체 기에 결합하도록 선택된다. 이작용성 연결 모이어티에서 사용된 작용기의 예는 친핵성 기와 반응하기 위한 친전자체 및 친전자성 기와 반응하기 위한 친핵체를 포함하지만, 이들로 제한되지 않는다. 특정 실시형태에서, 이작용성 연결 모이어티는 아미노, 하이드록실, 카복실산, 티올, 알킬, 알켄일 및 알킨일로부터 선택된 하나 이상의 기를 포함한다.
접합체 링커의 예는 피롤리딘, 8-아미노-3,6-다이옥사옥탄산(ADO), 석신이미딜 4-(N-말레이미도메틸) 사이클로-헥산-1-카복실레이트(SMCC) 및 6-아미노헥산산(AHEX 또는 AHA)을 포함하지만, 이들로 제한되지 않는다. 다른 접합체 링커는 치환된 또는 비치환된 C1-C10 알킬, 치환된 또는 비치환된 C2-C10 알켄일 또는 치환된 또는 비치환된 C2-C10 알킨일(여기서, 바람직한 치환기의 비제한적인 목록은 하이드록실, 아미노, 알콕시, 카복시, 벤질, 페닐, 나이트로, 티올, 티오알콕시, 할로겐, 알킬, 아릴, 알켄일 및 알킨일을 포함함)을 포함하지만, 이들로 제한되지 않는다.
특정 실시형태에서, 접합체 링커는 1개 내지 10개의 링커-뉴클레오사이드를 포함한다. 특정 실시형태에서, 접합체 링커는 2개 내지 5개의 링커-뉴클레오사이드를 포함한다. 특정 실시형태에서, 접합체 링커는 정확히 3개의 링커-뉴클레오사이드를 포함한다. 특정 실시형태에서, 접합체 링커는 TCA 모티프를 포함한다. 특정 실시형태에서, 이러한 링커-뉴클레오사이드는 변형된 뉴클레오사이드이다. 특정 실시형태에서 이러한 링커-뉴클레오사이드는 변형된 당 모이어티를 포함한다. 특정 실시형태에서, 링커-뉴클레오사이드는 비변형된다. 특정 실시형태에서, 링커-뉴클레오사이드는 퓨린, 치환된 퓨린, 피리미딘 또는 치환된 피리미딘으로부터 선택된 선택적으로 보호된 복소환식 염기를 포함한다. 특정 실시형태에서, 절단 가능한 모이어티는 유라실, 타이민, 사이토신, 4-N-벤조일사이토신, 5-메틸 사이토신, 4-N-벤조일-5-메틸 사이토신, 아데닌, 6-N-벤조일아데닌, 구아닌 및 2-N-아이소부티릴구아닌으로부터 선택된 뉴클레오사이드이다. 전형적으로, 링커-뉴클레오사이드가 표적 조직에 도달한 후 올리고머 화합물로부터 절단되는 것이 바람직하다. 따라서, 링커-뉴클레오사이드는 통상적으로 서로에 그리고 절단 가능한 결합을 통해 올리고머 화합물의 나머지에 연결된다. 특정 실시형태에서, 이러한 절단 가능한 결합은 포스포다이에스터 결합이다.
여기서, 링커-뉴클레오사이드는 올리고뉴클레오타이드의 일부인 것으로 생각되지 않는다. 따라서, 올리고머 화합물이 연결된 뉴클레오사이드의 기재된 수 또는 범위 및/또는 기준 핵산에 대한 기재된 상보성 백분율로 이루어진 올리고뉴클레오타이드를 포함하고, 올리고머 화합물이 또한 링커-뉴클레오사이드를 포함하는 접합체 링커를 포함하는 접합체 기를 포함하는 실시형태에서, 이러한 링커-뉴클레오사이드는 올리고뉴클레오타이드의 길이를 향해 계수되지 않고, 기준 핵산에 대한 올리고뉴클레오타이드의 상보성 백분율을 결정하는 데 사용되지 않는다. 예를 들어, 올리고머 화합물은 (1) 8개 내지 30개의 뉴클레오사이드로 이루어진 변형된 올리고뉴클레오타이드 및 (2) 변형된 올리고뉴클레오타이드의 뉴클레오사이드와 인접한 1개 내지 10개의 링커-뉴클레오사이드를 포함하는 접합체 기를 포함할 수 있다. 이러한 올리고머 화합물에서 인접한 연결된 뉴클레오사이드의 전체 수는 30개 초과이다. 대안적으로, 올리고머 화합물은 접합체 기 없이 8개 내지 30개의 뉴클레오사이드로 이루어진 변형된 올리고뉴클레오타이드를 포함할 수 있다. 이러한 올리고머 화합물에서 인접한 연결된 뉴클레오사이드의 전체 수는 30개 미만이다. 달리 표시되지 않는 한, 접합체 링커는 10개 이하의 링커-뉴클레오사이드를 포함한다. 특정 실시형태에서, 접합체 링커는 5개 이하의 링커-뉴클레오사이드를 포함한다. 특정 실시형태에서, 접합체 링커는 3개 이하의 링커-뉴클레오사이드를 포함한다. 특정 실시형태에서, 접합체 링커는 2개 이하의 링커-뉴클레오사이드를 포함한다. 특정 실시형태에서, 접합체 링커는 1개 이하의 링커-뉴클레오사이드를 포함한다.
특정 실시형태에서, 접합체 기가 올리고뉴클레오타이드로부터 절단되는 것이 바람직하다. 예를 들어, 특정 상황에서, 특정 접합체 모이어티를 포함하는 올리고머 화합물은 특정 세포 유형에 의해 더 양호하게 흡수되지만, 올리고머 화합물이 흡수되면, 절단된 접합체 기가 비접합된 또는 모 올리고뉴클레오타이드를 방출하는 것이 바람직하다. 따라서, 특정 접합체 링커는 하나 이상의 절단 가능한 모이어티를 포함할 수 있다. 특정 실시형태에서, 절단 가능한 모이어티는 절단 가능한 결합이다. 특정 실시형태에서, 절단 가능한 모이어티는 적어도 하나의 절단 가능한 결합을 포함하는 원자의 기이다. 특정 실시형태에서, 절단 가능한 모이어티는 1개, 2개, 3개, 4개 또는 4개 초과의 절단 가능한 결합을 갖는 원자의 기를 포함한다. 특정 실시형태에서, 절단 가능한 모이어티는 세포 또는 세포하 구획, 예컨대, 리소좀 내에서 선택적으로 절단된다. 특정 실시형태에서, 절단 가능한 모이어티는 내인성 효소, 예컨대, 뉴클레아제에 의해 선택적으로 절단된다.
특정 실시형태에서, 절단 가능한 결합은 아마이드, 에스터, 에터, 포스포다이에스터의 에스터 중 하나 또는 둘 다, 포스페이트 에스터, 카바메이트 또는 다이설파이드로부터 선택된다. 특정 실시형태에서, 절단 가능한 결합은 포스포다이에스터의 에스터 중 하나 또는 둘 다이다. 특정 실시형태에서, 절단 가능한 모이어티는 포스페이트 또는 포스포다이에스터를 포함한다. 특정 실시형태에서, 절단 가능한 모이어티는 올리고뉴클레오타이드와 접합체 모이어티 또는 접합체 기 사이의 포스페이트 연결이다.
특정 실시형태에서, 절단 가능한 모이어티는 하나 이상의 링커-뉴클레오사이드를 포함하거나 이것으로 이루어진다. 이러한 특정 실시형태에서, 하나 이상의 링커-뉴클레오사이드는 서로에 및/또는 절단 가능한 결합을 통해 올리고머 화합물의 나머지에 연결된다. 특정 실시형태에서, 이러한 절단 가능한 결합은 비변형된 포스포다이에스터 결합이다. 특정 실시형태에서, 절단 가능한 모이어티는 포스페이트 뉴클레오사이드간 링키지에 의해 올리고뉴클레오타이드의 3' 또는 5'-말단 뉴클레오사이드에 부착되고, 포스페이트 또는 포스포로티오에이트 연결에 의해 접합체 링커 또는 접합체 모이어티의 나머지에 공유 부착된 2'-데옥시 뉴클레오사이드이다. 이러한 특정 실시형태에서, 절단 가능한 모이어티는 2'-데옥시아데노신이다.
B.
특정 말단 기
특정 실시형태에서, 올리고머 화합물은 하나 이상의 말단 기를 포함한다. 이러한 특정 실시형태에서, 올리고머 화합물은 안정화된 5'-포스페이트를 포함한다. 안정화된 5'-포스페이트는 5'-포스포네이트, 예를 들어 5'-바이닐포스포네이트(이들로 제한되지 않음)를 포함하지만, 이들로 제한되지 않는다. 특정 실시형태에서, 말단 기는 하나 이상의 비염기성 뉴클레오사이드 및/또는 역전(inverted) 뉴클레오사이드를 포함한다. 특정 실시형태에서, 말단 기는 하나 이상의 2'-연결된 뉴클레오사이드를 포함한다. 이러한 특정 실시형태에서, 2'-연결된 뉴클레오사이드는 비염기성 뉴클레오사이드이다.
III. 올리고머 듀플렉스
특정 실시형태에서, 본 명세서에 기재된 올리고머 화합물은 표적 핵산의 것에 상보성인 핵염기 서열을 갖는 올리고뉴클레오타이드를 포함한다. 특정 실시형태에서, 올리고머 화합물은 제2 올리고머 화합물과 짝을 이루어 올리고머 듀플렉스를 형성한다. 이러한 올리고머 듀플렉스는 표적 핵산에 상보성인 영역을 갖는 제1 올리고머 화합물 및 제1 올리고머 화합물에 상보성인 영역을 갖는 제2 올리고머 화합물을 포함한다. 특정 실시형태에서, 올리고머 듀플렉스의 제1 올리고머 화합물은 (1) 변형된 또는 비변형된 올리고뉴클레오타이드 및 임의로 접합체 기 및 (2) 제2 변형된 또는 비변형된 올리고뉴클레오타이드 및 임의로 접합체 기를 포함하거나, 이들로 이루어진다. 올리고머 듀플렉스의 올리고머 화합물 중 어느 하나 또는 둘 다는 접합체 기를 포함할 수 있다. 올리고머 듀플렉스의 각각의 올리고머 화합물의 올리고뉴클레오타이드는 비상보성 오버행잉(overhanging) 뉴클레오사이드를 포함할 수 있다.
IV.
안티센스 활성
특정 실시형태에서, 올리고머 화합물 및 올리고머 듀플렉스는 표적 핵산에 혼성화하여서, 적어도 하나의 안티센스 활성을 발생시킬 수 있고; 이러한 올리고머 화합물 및 올리고머 듀플렉스는 안티센스 화합물이다. 특정 실시형태에서, 안티센스 화합물은 표준 세포 검정에서 표적 핵산의 양 또는 활성을 25% 이상만큼 감소시키거나 저해할 때 안티센스 활성을 갖는다. 특정 실시형태에서, 안티센스 화합물은 하나 이상의 표적 핵산에 선택적으로 영향을 미친다. 이러한 안티센스 화합물은 하나 이상의 표적 핵산에 혼성화하여서, 하나 이상의 원하는 안티센스 활성을 발생시키거나, 하나 이상의 비표적 핵산에 혼성화하지 않거나, 상당한 원치 않는 안티센스 활성을 발생시키는 방식으로 하나 이상의 비표적 핵산에 혼성화하지 않는 핵염기 서열을 포함한다.
특정 안티센스 활성에서, 표적 핵산에 대한 안티센스 화합물의 혼성화는 표적 핵산을 절단하는 단백질의 동원을 발생시킨다. 예를 들어, 특정 안티센스 화합물은 표적 핵산의 RNase H 매개된 절단을 발생시킨다. RNase H는 RNA:DNA 듀플렉스의 RNA 가닥을 절단시키는 세포 엔도뉴클레아제이다. 이러한 RNA:DNA 듀플렉스에서의 DNA는 비변형된 DNA일 필요는 없다. 특정 실시형태에서, RNase H 활성을 유발하도록 충분히 "DNA 유사한" 안티센스 화합물이 본 명세서에 기재된다. 특정 실시형태에서, 갭머의 갭에서 하나 이상의 비-DNA-유사 뉴클레오사이드는 관용된다.
특정 안티센스 활성에서, 안티센스 화합물 또는 안티센스 화합물의 일부는 RNA 유도된 슬라이싱 복합체(RNA-induced silencing complex: RISC)로 로딩되어서, 궁극적으로 표적 핵산을 절단시킨다. 예를 들어, 특정 안티센스 화합물은 Argonaute에 의한 표적 핵산의 절단을 발생시킨다. RISC로 로딩된 안티센스 화합물은 RNAi 화합물이다. RNAi 화합물은 이중 가닥(siRNA) 또는 단일 가닥(ssRNA)일 수 있다.
특정 실시형태에서, 표적 핵산에 대한 안티센스 화합물의 혼성화는 표적 핵산을 절단하는 단백질의 동원을 발생시키지 않는다. 특정 실시형태에서, 표적 핵산에 대한 안티센스 화합물의 혼성화는 표적 핵산의 스플라이싱의 변경을 발생시킨다. 특정 실시형태에서, 표적 핵산에 대한 안티센스 화합물의 혼성화는 표적 핵산과 단백질 또는 다른 핵산 사이의 결합 상호작용의 저해를 발생시킨다. 특정 실시형태에서, 표적 핵산에 대한 안티센스 화합물의 혼성화는 표적 핵산의 번역을 변경을 발생시킨다.
안티센스 활성은 직접적으로 또는 간접적으로 관찰될 수 있다. 특정 실시형태에서, 안티센스 활성의 관찰 또는 검출은 이러한 표적 핵산에 의해 암호화된 표적 핵산 또는 단백질의 양의 변화, 핵산 또는 단백질의 스플라이스 변이체의 비율의 변화 및/또는 세포 또는 대상체에서의 표현형 변화의 관찰 또는 검출을 수반한다.
V.
특정 표적 핵산
특정 실시형태에서, 올리고머 화합물은 표적 핵산에 상보성인 영역을 포함하는 올리고뉴클레오타이드를 포함하거나 이것으로 이루어진다. 특정 실시형태에서, 표적 핵산은 내인성 RNA 분자이다. 특정 실시형태에서, 표적 핵산은 단백질을 암호화한다. 이러한 특정 실시형태에서, 표적 핵산은 성숙 mRNA 및 프리-mRNA, 예를 들어 인트론, 엑손 및 비번역된 영역으로부터 선택된다. 특정 실시형태에서, 표적 RNA는 성숙 mRNA이다. 특정 실시형태에서, 표적 핵산은 프리-mRNA이다. 이러한 특정 실시형태에서, 표적 영역은 전부 인트론 내에 존재한다. 특정 실시형태에서, 표적 영역은 인트론/엑손 접합부에 걸쳐있다. 특정 실시형태에서, 표적 영역은 인트론 내에 적어도 50%에 존재한다. 특정 실시형태에서, 표적 핵산은 레트로겐(retrogene)의 RNA 전사 산물이다. 특정 실시형태에서, 표적 핵산은 비-암호 RNA이다. 이러한 특정 실시형태에서, 표적 비-암호 RNA는 긴 비-암호 RNA, 짧은 비-암호 RNA, 인트론 RNA 분자로부터 선택된다.
A.
표적 핵산에 대한 상보성/미스매치
활성을 제거하지 않으면서 미스매치 염기를 도입할 수 있다. 예를 들어, Gautschi 등(문헌[J. Natl. Cancer Inst. 93:463-471, March 2001])은 시험관내 및 생체내에서 bcl-2 및 bcl-xL 둘 다의 발현을 감소시키는, bcl-2 mRNA와 100% 상보성을 갖고, bcl-xL mRNA에 대해 3개의 미스매치를 갖는 올리고뉴클레오타이드의 능력을 입증하였다. 더욱이, 이 올리고뉴클레오타이드는 생체내에서 강력한 항-종양 활성을 나타내었다. Maher 및 Dolnick(문헌[Nuc. Acid. Res. 16:3341-3358, 1988])는 토끼 망상적혈구 검정에서 인간 DHFR의 번역을 막는 이의 능력에 대해 각각 일련의 탠덤 14개의 핵염기 올리고뉴클레오타이드, 및 2개 또는 3개의 탠덤 올리고뉴클레오타이드의 서열로 이루어진 28개 및 42개의 핵염기 올리고뉴클레오타이드를 시험하였다. 3개의 14개 핵염기 올리고뉴클레오타이드는 각각 단독으로 28개 또는 42개의 핵염기 올리고뉴클레오타이드보다 더 적당한 수준이긴 하지만, 번역을 저해할 수 있었다.
특정 실시형태에서, 올리고뉴클레오타이드는 올리고뉴클레오타이드의 전체 길이에 걸쳐 표적 핵산과 상보성이다. 특정 실시형태에서, 올리고뉴클레오타이드는 표적 핵산과 99%, 95%, 90%, 85% 또는 80% 상보성이다. 특정 실시형태에서, 올리고뉴클레오타이드는 올리고뉴클레오타이드의 전체 길이에 걸쳐 표적 핵산과 적어도 80% 상보성이고, 표적 핵산에 100% 또는 전부 상보성인 영역을 포함한다. 특정 실시형태에서, 완전 상보성의 영역은 6개 내지 20개, 10개 내지 18개 또는 18개 내지 20개의 핵염기 길이이다.
특정 실시형태에서, 올리고뉴클레오타이드는 표적 핵산에 대해 하나 이상의 미스매칭된 핵염기를 포함한다. 특정 실시형태에서, 표적에 대한 안티센스 활성은 이러한 미스매치에 의해 감소하지만, 비표적에 대한 활성은 더 높은 양만큼 감소한다. 따라서, 특정 실시형태에서, 올리고뉴클레오타이드의 선택성이 개선된다. 특정 실시형태에서, 미스매치는 갭머 모티프를 갖는 올리고뉴클레오타이드 내에 특이적으로 배치된다. 특정 실시형태에서, 미스매치는 갭 영역의 5'-단부로부터 1, 2, 3, 4, 5, 6, 7 또는 8 위치에 존재한다. 특정 실시형태에서, 미스매치는 갭 영역의 3'-단부로부터 9, 8, 7, 6, 5, 4, 3, 2, 1 위치에 존재한다. 특정 실시형태에서, 미스매치는 윙 영역의 5'-단부로부터 1, 2, 3 또는 4 위치에 존재한다. 특정 실시형태에서, 미스매치는 윙 영역의 3' 단부로부터 4, 3, 2 또는 1 위치에 존재한다.
B.
KCNT1
특정 실시형태에서, 올리고머 화합물은 KCNT1 핵산과 상보성인 영역을 포함하는 올리고뉴클레오타이드를 포함하거나 이것으로 이루어진다. 특정 실시형태에서, KCNT1 핵산은 서열번호 1(진뱅크 수탁 번호: NM_020822.2)에 제시된 서열을 갖는다. 특정 실시형태에서, KCNT1 핵산은 서열번호 2(진뱅크 수탁 번호: 뉴클레오타이드 135698001 내지 135796000로부터 절두된 NC_000009.12)에 제시된 서열을 갖는다. 특정 실시형태에서, KCNT1핵산은 서열번호 1의 스플라이싱 변이체인, 서열번호 3(진뱅크 수탁 번호: NM_020822.3)에 제시된 서열을 갖는다.
특정 실시형태에서 서열번호 1, 서열번호 2 또는 서열번호 3과 상보성인 올리고머 화합물은 세포에서 KCNT1 RNA를 감소시킬 수 있다. 특정 실시형태에서 서열번호 1, 서열번호 2 또는 서열번호 3과 상보성인 올리고머 화합물은 세포에서 KCNT1 단백질을 감소시킬 수 있다. 특정 실시형태에서, 세포는 시험관내에 존재한다. 특정 실시형태에서, 세포는 대상체에 존재한다. 특정 실시형태에서, 올리고머 화합물은 변형된 올리고뉴클레오타이드로 이루어진다. 특정 실시형태에서, 서열번호 1, 서열번호 2 또는 서열번호 3과 상보성인 올리고머 화합물은, 그것이 대상체의 세포에 도입되는 경우 신경학적 병태의 하나 이상의 증상 또는 특징을 개선할 수 있다. 특정 실시형태에서, 신경학적 병태는 뇌전증을 포함한다. 특정 실시형태에서, 하나 이상의 증상 또는 특징은 발작, 뇌 손상, 탈수초, 근기능 저하, 소두증, 우울증, 불안, 인지 기능 이상 및 이들의 조합으로부터 선택된다.
특정 실시형태에서, 서열번호 1, 서열번호 2 또는 서열번호 3과 상보성인 올리고머 화합물은, 올리고머 화합물이 대상체의 CSF에 투여되는 경우 대상체의 CSF에서 KCNT1 RNA의 검출 가능한 양을 감소시킬 수 있다. KCNT1 RNA의 검출 가능한 양은 적어도 10%, 적어도 20%, 적어도 30%, 적어도 40%, 적어도 50%, 적어도 60%, 적어도 70%, 적어도 80% 또는 적어도 90%만큼 감소될 수 있다. 특정 실시형태에서, 서열번호 1, 서열번호 2 또는 서열번호 3과 상보성인 올리고머 화합물은, 올리고머 화합물이 대상체의 CSF에 투여되는 경우 대상체의 CSF에서 KCNT1 단백질의 검출 가능한 양을 감소시킬 수 있다. KCNT1 단백질의 검출 가능한 양은 적어도 10%, 적어도 20%, 적어도 30%, 적어도 40%, 적어도 50%, 적어도 60%, 적어도 70%, 적어도 80% 또는 적어도 90%만큼 감소될 수 있다.
C.
특정 조직에서의 특정 표적 핵산
특정 실시형태에서, 올리고머 화합물은 표적 핵산과 상보성인 영역을 포함하는 올리고뉴클레오타이드를 포함하거나 이것으로 이루어지고, 여기서 표적 핵산은 약리학적으로 관련된 조직에서 발현된다. 특정 실시형태에서, 약리학적으로 관련된 조직은 중치신경계(CNS)를 포함하는 조직 및 세포이다. 이러한 조직은 뇌 조직, 예컨대, 피질, 흑질, 선조체, 중뇌, 뇌간 및 척수를 포함한다.
VI.
특정 약제학적 조성물
특정 실시형태에서, 본 명세서에는 1종 이의 올리고머 화합물을 포함하는 약제학적 조성물이 기재된다. 특정 실시형태에서, 1종 이상의 올리고머 화합물은 각각 변형된 올리고뉴클레오타이드로 이루어진다. 특정 실시형태에서, 약제학적 조성물은 약제학적으로 허용 가능한 희석제 또는 담체를 포함한다. 특정 실시형태에서, 약제학적 조성물은 무균 식염수 용액 및 1종의 올리고머 화합물을 포함하거나 이것으로 이루어진다. 특정 실시형태에서, 무균 식염수는 약제학적 등급 식염수이다. 특정 실시형태에서, 약제학적 조성물은 1종 이상의 올리고머 화합물 및 무균수를 포함하거나 이것으로 이루어진다. 특정 실시형태에서, 무균 물은 약제학적 등급 물이다. 특정 실시형태에서, 약제학적 조성물은 1종 이상의 올리고머 화합물 및 인산염 완충 식염수(PBS)를 포함하거나 이것으로 이루어진다. 특정 실시형태에서, 무균 PBS는 약제학적 등급 PBS이다. 특정 실시형태에서, 약제학적 조성물은 1종 이상의 올리고머 화합물 및 인공 뇌척수액을 포함하거나 이것으로 이루어진다. 특정 실시형태에서, 인공 뇌척수액은 약제학적 등급이다.
특정 실시형태에서, 약제학적 조성물은 변형된 올리고뉴클레오타이드 및 인공 뇌척수액을 포함한다. 특정 실시형태에서, 약제학적 조성물은 변형된 올리고뉴클레오타이드 및 인공 뇌척수액으로 이루어진다. 특정 실시형태에서, 약제학적 조성물은 변형된 올리고뉴클레오타이드 및 인공 뇌척수액으로 본질적으로 이루어진다. 특정 실시형태에서, 인공 뇌척수액은 약제학적 등급이다.
특정 실시형태에서, 약제학적 조성물은 하나 이상의 올리고머 화합물 및 하나 이상의 부형제를 포함한다. 특정 실시형태에서, 부형제는 물, 염 용액, 알코올, 폴리에틸렌 글리콜, 젤라틴, 락토스, 아밀라제, 스테아르산마그네슘, 탤크, 규산, 점성 파라핀, 하이드록시메틸셀룰로스 및 폴리바이닐피롤리돈으로부터 선택된다.
특정 실시형태에서, 올리고머 화합물은 약제학적 조성물 또는 제제의 제조를 위해 약제학적으로 허용 가능한 활성 및/또는 불활성 물질과 혼합될 수 있다. 약제학적 조성물의 제제에 대한 조성물 및 방법은 투여 경로, 질환의 정도 또는 투여되는 용량(이들로 제한되지 않음)을 포함하는 다수의 기준에 따라 달라진다.
특정 실시형태에서, 올리고머 화합물을 포함하는 약제학적 조성물은 올리고머 화합물의 임의의 약제학적으로 허용 가능한 염, 올리고머 화합물의 에스터 또는 이러한 에스터의 염을 포함한다. 특정 실시형태에서, 하나 이상의 올리고뉴클레오타이드를 포함하는 올리고머 화합물을 포함하는 약제학적 조성물은, 인간을 포함하는 대상체에 대한 투여 시, 생물학적으로 활성인 대사물질 또는 이의 잔류물을 (직접적으로 또는 간접적으로) 제공할 수 있다. 따라서, 예를 들어 본 개시내용은 또한 올리고머 화합물의 약제학적으로 허용 가능한 염, 전구약물, 이러한 전구약물의 약제학적으로 허용 가능한 염 및 다른 생물등가물에 관한 것이다. 적합한 약제학적으로 허용 가능한 염은 나트륨염 및 칼륨염을 포함하지만, 이들로 제한되지 않는다. 특정 실시형태에서, 전구약물은 올리고뉴클레오타이드에 부착된 하나 이상의 접합체 기를 포함하고, 접합체 기는 신체 내의 내인성 뉴클레아제에 의해 절단된다.
지질 모이어티는 다양한 방법에서 핵산 치료에서 사용된다. 이러한 특정 방법에서, 핵산, 예컨대, 올리고머 화합물은 양이온성 지질 및 중성 지질의 혼합물로 이루어진 미리 형성된 리포솜 또는 리포플렉스에 도입된다. 특정 방법에서, 모노- 또는 폴리-양이온성 지질과의 DNA 복합체는 중성 지질의 존재 없이 형성된다. 특정 실시형태에서, 지질 모이어티는 특정 세포 또는 조직에 대한 약제학적 작용제의 분포를 증가시키도록 선택된다. 특정 실시형태에서, 지질 모이어티는 지방 조직에 대한 약제학적 작용제의 분포를 증가시키도록 선택된다. 특정 실시형태에서, 지질 모이어티는 근육 조직에 대한 약제학적 작용제의 분포를 증가시키도록 선택된다.
특정 실시형태에서, 약제학적 조성물은 전달 시스템을 포함한다. 전달 시스템의 예는 리포솜 및 에멀션을 포함하지만, 이들로 제한되지 않는다. 특정 전달 시스템은 특정 약제학적 조성물, 예를 들어 소수성 화합물을 포함하는 것을 제조하는 데 유용하다. 특정 실시형태에서, 특정 유기 용매, 예컨대, 다이메틸설폭사이드를 사용한다.
특정 실시형태에서, 약제학적 조성물은 특이적 조직 또는 세포 유형에 본 발명의 하나 이상의 약제학적 작용제를 전달하도록 설계된 하나 이상의 조직 특이적 전달 분자를 포함한다. 예를 들어, 특정 실시형태에서, 약제학적 조성물은 조직 특이적 항체로 코팅된 리포솜을 포함한다.
특정 실시형태에서, 약제학적 조성물은 공용매 시스템을 포함한다. 이러한 특정 공용매 시스템은 예를 들어 벤질 알코올, 비극성 계면활성제, 수혼화성 유기 중합체 및 수성 상을 포함한다. 특정 실시형태에서, 이러한 공용매 시스템은 소수성 화합물에 사용된다. 이러한 공용매 시스템의 비제한적인 예는 3% w/v의 벤질 알코올, 8% w/v의 비극성 계면활성제 폴리솔베이트 80™ 및 65% w/v의 폴리에틸렌 글리콜 300을 포함하는 절대 에탄올의 용액인 VPD 공용매 시스템이다. 이러한 공용매 시스템의 비율은 이의 용해도 및 독성 특징을 변경시키지 유의하게 않으면서 상당히 달라질 수 있다. 더욱이, 공용매 성분의 정체는 변할 수 있고, 예를 들어, 폴리솔베이트 80™ 대신에 다른 계면활성제를 사용할 수 있고, 폴리에틸렌 글리콜의 분율 크기는 변할 수 있고, 다른 생체적합성 중합체는 폴리에틸렌 글리콜, 예를 들어, 폴리바이닐 피롤리돈을 대체할 수 있고, 다른 당 또는 다당류는 덱스트로스를 대체할 수 있다.
특정 실시형태에서, 약제학적 조성물은 경구 투여를 위해 제조된다. 특정 실시형태에서, 약제학적 조성물은 협측 투여를 위해 제조된다. 특정 실시형태에서, 약제학적 조성물은 주사(예를 들어, 정맥내, 피하, 근육내, 척추강내(IT), 뇌실내(ICV) 등)에 의한 투여를 위해 제조된다. 이러한 특정 실시형태에서, 약제학적 조성물은 담체를 포함하고, 수성 용액, 예컨대, 물 또는 생리학적으로 상용성인 완충액, 예컨대, 행크 용액, 링거액 또는 생리학적 식염수 완충액 중에 제형화된다. 특정 실시형태에서, 다른 성분(예를 들어, 용해성을 돕거나 보존제로서 작용하는 성분)이 포함된다. 특정 실시형태에서, 주사용 현탁액은 적절한 액체 담체, 현탁화제 등을 사용하여 제조된다. 특정 주사용 약제학적 조성물은 단위 투여 형태, 예를 들어, 앰플 또는 다회-용량 용기에 존재한다. 특정 주사용 약제학적 조성물은 유성 또는 수성 비히클 중의 현탁액, 용액 또는 에멀션이고, 제형화제, 예컨대, 현탁화제, 안정화제 및/또는 분산제를 함유할 수 있다. 주사용 약제학적 조성물에서 사용하기에 적합한 특정 용매는 친유성 용매 및 지방 오일, 예컨대, 참깨유, 합성 지방산 에스터, 예컨대, 에틸 올레에이트 또는 트라이글리세리드 및 리포솜을 포함하지만, 이들로 제한되지 않는다.
특정 조건 하에서, 본 명세서에 개시된 특정 화합물은 산으로서 작용한다. 이러한 화합물은 양성자화된(유리산) 형태 또는 이온화된 형태로 또는 양이온(염) 형태로 회합되어 도시되거나 기재되지만, 이러한 화합물의 수성 용액은 이러한 형태 사이에서 평형으로 존재한다. 예를 들어, 수성 용액 중의 올리고뉴클레오타이드의 포스페이트 링키지는 유리산, 음이온 및 염 형태 사이에서 평형으로 존재한다. 달리 제시되지 않는 한, 본 명세서에 기재된 화합물은 이러한 모든 형태를 포함하도록 의도된다. 더욱이, 특정 올리고뉴클레오타이드는 수 개의 이러한 링키지를 갖고, 이들 각각은 평형으로 존재한다. 따라서, 용액 중의 올리고뉴클레오타이드는 모두 평형 상태의 다수의 위치에서의 형태의 앙상블로 존재한다. 용어 "올리고뉴클레오타이드"는 이러한 모든 형태를 포함하도록 의도된다. 도시된 구조는 본질적으로 단일 형태를 도시한다. 그럼에도 불구하고, 달리 제시되지 않는 한, 이러한 도시는 마찬가지로 상응하는 형태를 포함하도록 의도된다. 본 명세서에서, 용어 "또는 이의 염" 앞의 화합물의 유리산을 도시한 구조는 완전히 또는 부분적으로 양성자화/탈양성자화/양이온과 회합될 수 있는 이러한 모든 형태를 명확하게 포함한다. 특정 예에서, 하나 이상의 특정 양이온이 식별된다.
특정 실시형태에서, 변형된 올리고뉴클레오타이드 또는 올리고머 화합물은 나트륨을 함유하는 수용액 중에 존재한다. 특정 실시형태에서, 변형된 올리고뉴클레오타이드 또는 올리고머 화합물은 칼륨을 함유하는 수용액 중에 존재한다. 특정 실시형태에서, 변형된 올리고뉴클레오타이드 또는 올리고머 화합물은 PBS 중에 존재한다. 특정 실시형태에서, 변형된 올리고뉴클레오타이드 또는 올리고머 화합물은 물 중에 존재한다. 이러한 특정 실시형태에서, 용액의 pH는 NaOH 및/또는 HCl을 사용하여 조정되어 목적하는 pH를 달성한다.
본 명세서에서, 특정 특이적 용량이 기재된다. 용량은 투여량 단위의 형태로 존재할 수 있다. 명확성을 위해서, 밀리그램 단위의 변형된 올리고뉴클레오타이드 또는 올리고머 화합물의 용량(또는 투여량 단위)은 변형된 올리고뉴클레오타이드 또는 올리고머 화합물의 유리산 형태의 질량을 나타낸다. 상기에 기재된 바와 같이, 수성 용액에서, 유리산은 음이온 형태 및 염 형태와 평형으로 존재한다. 그러나, 용량 계산의 목적으로, 변형된 올리고뉴클레오타이드 또는 올리고머 화합물은 용매-무함유, 아세트산나트륨 무함유, 무수, 유리산의 존재한다고 가정한다. 예를 들어, 변형된 올리고뉴클레오타이드 또는 올리고머 화합물이 나트륨을 포함하는 용액(예를 들어, 식염수)에 존재하는 경우, 변형된 올리고뉴클레오타이드 또는 올리고머 화합물은 부분적으로 또는 완전히 탈양성자화되고, Na+ 이온과 회합하여 존재할 수 있다. 그러나, 그럼에도 불구하고 양성자의 질량은 용량의 중량에 대해서 계산되고, Na+ 이온의 질량은 용량의 중량에 대해서 계산되지 않는다. 따라서, 예를 들어, 80mg의 용량 또는 투여량 단위의 화합물 번호 1080855 는 80mg 중량의 완전히 양성자화된 분자의 수와 동일하다. 이것은 용매-무함유, 아세트산나트륨-무함유, 무수 나트륨화(sodiated) 화합물 번호 1080855의 85 mg과 동일할 것이다. 올리고머 화합물이 접합체 기를 포함하는 경우, 접합체 기의 질량은 이러한 올리고머 화합물의 용량을 계산하는데 포함된다. 접합체 기가 산을 갖는 경우, 접합체 기는 마찬가지로 용량 계산의 목적을 위해서 완전히 양성자화된다고 가정된다.
비제한적인 개시내용 및 참조에 의한 포함
본 명세서에 열거된 각각의 문헌 및 특허 공보는 그 전문이 참고에 의해 포함된다.
본 명세서에 기재된 특정 화합물, 조성물 및 방법이 특정 실시형태에 따라 구체적으로 기재되어 있지만, 하기 실시예는 단지 본 명세서에 기재된 화합물을 예시하기 위해서 제공되며, 이를 제한하는 것으로 의도되지 않는다. 본 출원에 기재된 각각의 참고문헌, 진뱅크 수탁 번호 등은 그 전문이 참조에 의해 본 명세서에 포함된다.
본 출원에 첨부된 서열 목록은 필요한 경우 "RNA" 또는 "DNA"로서 각각의 서열을 식별하지만, 실제로, 이 서열은 화학 변형의 임의의 조합에 의해 변형될 수 있다. 당업자는 변형된 올리고뉴클레오타이드를 기재하기 위한 "RNA" 또는 "DNA"로서의 이의 지칭이 특정 경우에 임의적이라는 것을 용이하게 이해할 것이다. 예를 들어, 2'-OH 당 모이어티 및 타이민 염기를 포함하는 뉴클레오사이드를 포함하는 올리고뉴클레오타이드는 변형된 당을 갖는 DNA(DNA의 하나의 2'-H 대신에 2'-OH)로서 또는 변형된 염기를 갖는 RNA(RNA의 유라실 대신에 티민(메틸화된 유라실))로서 기재될 수 있다. 따라서, 서열 목록에서의 것(이들로 제한되지 않음)을 포함하는 본 명세서에 제공된 핵산 서열은 천연 또는 변형된 RNA 및/또는 DNA, 예를 들어 변형된 핵염기를 갖는 이러한 핵산(이들로 제한되지 않음)의 임의의 조합을 함유하는 핵산을 포함하도록 의도된다. 추가의 예의 방식으로, 비제한적으로, 핵염기 서열 "ATCGATCG"를 갖는 올리고머 화합물은, 변형되든 또는 비변형되든, 이러한 핵염기 서열을 갖는 임의의 올리고머 화합물, 예를 들어, RNA 염기를 포함하는 이러한 화합물, 예컨대, 서열 "AUCGAUCG"를 갖는 것 및 몇몇 DNA 염기 및 몇몇 RNA 염기를 갖는 것, 예컨대, "AUCGATCG" 및 다른 변형된 핵염기를 갖는 올리고머 화합물, 예컨대, "ATmCGAUCG"(여기서, mC는 5-위치에서 메틸기를 포함하는 사이토신 염기를 나타냄)(이들로 제한되지 않음)을 포함한다.
본 명세서에 기재된 특정 화합물(예를 들어, 변형된 올리고뉴클레오타이드)은 하나 이상의 비대칭 중심을 갖고, 이에 따라 (R) 또는 (S)로서, 예컨대, 당 아노머에 대해 α 또는 β로서, 또는 예컨대, 아미노산 등에 대해 (D) 또는 (L)로서 절대 입체화학과 관련하여 한정될 수 있는 거울상이성질체, 부분입체이성질체 및 다른 입체이성질체 배위를 발생시킨다. 특정 입체이성질체 배위를 갖는 것으로 도시되거나 기재된 본 명세서에 제공된 화합물은 제시된 화합물 만을 포함한다. 비한정된 입체화학에 의해 도시되거나 기재된 본 명세서에 제공된 화합물은, 달리 기재되지 않는 한, 모든 이러한 가능한 이성질체, 예를 들어, 이의 입체무작위 및 광학적으로 순수한 형태를 포함한다. 마찬가지로, 달리 표시되지 않는 한 본 명세서에서 화합물의 호변이성질체 형태가 또한 포함된다. 달리 제시되지 않는 한, 본 명세서에 기재된 화합물은 상응하는 염 형태를 포함하도록 의도된다.
본 명세서에 기재된 화합물은 하나 이상의 원자가 표시된 원소의 비방사성 동위원소 또는 방사성 동위원소에 의해 대체된 변동을 포함한다. 예를 들어, 수소 원자를 포함하는 본 명세서에서 화합물은 각각의 1H 수소 원자에 대해 모든 가능한 중수소 치환을 포함한다. 본 명세서에서 화합물에 의해 포함된 동위원소 치환은 1H 대신에 2H 또는 3H, 12C 대신에 13C 또는 14C, 14N 대신에 15N, 16O 대신에 17O 또는 18O 및 32S 대신에 33S, 34S, 35S 또는 36S를 포함하지만, 이들로 제한되지 않는다. 특정 실시형태에서, 비방사성 동위원소 치환은 치료적 또는 연구 도구로서 사용하기에 유리한 올리고머 화합물에서 새로운 특성을 부여할 수 있다. 특정 실시형태에서, 방사성 동위원소 치환은 조사 또는 진단 목적, 예컨대, 영상화에 적합한 화합물을 만들 수 있다.
실시예
하기 실시예는 본 개시내용의 특정 실시형태를 예시하고, 제한이 아니다. 더구나, 구체적인 실시형태가 제공될 때, 본 발명자들은 이 구체적인 실시형태의 포괄적인 적용을 고려한다. 예를 들어, 특정 모티프를 갖는 올리고뉴클레오타이드의 개시내용이 동일하거나 유사한 모티프를 갖는 추가적인 올리고뉴클레오타이드에 대한 합당한 지원을 제공한다. 그리고, 예를 들어 특정 고친화도 변형이 특정 위치에서 나타날 때, 달리 표시되지 않는 다른 동일한 위치에서의 고친화도 변형은 적합하다고 간주된다.
실시예 1: 시험관내에서 인간 KCNT1 RNA에 대한 5-10-5 MOE 갭머 변형된 올리고뉴클레오타이드의 효과, 단일 용량
인간 KCNT1 핵산과 상보성인 변형된 올리고뉴클레오타이드를 시험관내에서 KCNT1 RNA 수준에 대한 효과에 대해서 시험하였다.
하기 표의 변형된 올리고뉴클레오타이드는 혼합 뉴클레오사이드간 링키지를 갖는 5-10-5 MOE 갭머이다. 이러한 갭머는 20개 뉴클레오사이드 길이이고, 여기서 중심 캡 분절은 10개의 2'-β-D-데옥시뉴클레오사이드로 이루어지고, 3' 및 5' 윙은 각각 5개의 2'-MOE 뉴클레오사이드로 이루어진다. 갭머에 대한 모티프는 (5'에서 3'로): eeeeeddddddddddeeeee이고; 식 중, 'd'는 2'-β-D-데옥시리보실 당 모이어티를 나타내고, 'e'는 2'-MOE 당 모이어티를 나타낸다. 갭머에 대한 뉴클레오사이드간 링키지 모티프는 (5'에서 3'로) soooossssssssssooss이고, 식 중 's'는 포스포로티오에이트 뉴클레오사이드간 링키지를 나타내고, 'o'는 포스포다이에스터 뉴클레오사이드간 링키지를 나타낸다. 모든 사이토신 잔기는 5-메틸사이토신이다.
"시작 부위"는 변형된 올리고뉴클레오타이드가 인간 유전자 서열에서 상보성인 5'-가장 가까운 뉴클레오사이드를 나타낸다. "종결 부위"는 변형된 올리고뉴클레오타이드가 인간 유전자 서열에서 상보성인 3'-가장 가까운 뉴클레오사이드를 나타낸다. 하기 표에 열거된 각각의 변형된 올리고뉴클레오타이드는 서열번호 1(진뱅크 수탁 번호 NM_020822.2) 또는 서열번호 2(진뱅크 수탁 번호 NC_000009.12, 뉴클레오타이드 135698001 내지 135796000으로부터 절두됨)와 100% 상보성이다. '해당 없음(N/A)'은 변형된 올리고뉴클레오타이드가 특정 유전자 서열과 100% 상보성이 아니라는 것을 나타낸다.
20,000개 세포/웰의 밀도로 배양된 SH-SY5Y 세포(신경모세포종 세포주)를 전기천공에 의해서 4,000nM의 변형된 올리고뉴클레오타이드로 처리하였다. 대략 24시간의 처리 시간 후, 총 RNA를 세포로부터 단리시키고, KCNT1 RNA 수준을 정량적 실시간 RTPCR로 측정하였다. 인간 KCNT1 프라이머 프로브 세트 RTS39508(정방향 서열 GTCAACGTGCAGACCATGT, 본 명세서에서 서열번호 11이라고 지정; 역방향 서열 TCGCTCCCTCTTTTCTAGTTTG, 본 명세서에서 서열번호 12라고 지정; 프로브 서열 AGCTCACCCACCCTTCCAACATG, 본 명세서에서 서열번호 13이라고 지정)을 사용하여 표 1 내지 표 6에 제시된 RNA 수준을 측정하였고, 인간 KCNT1 프라이머 프로브 세트 RTS39496(정방향 서열 CAGGTGGAGTTCTACGTCAA, 본 명세서에서 서열번호 14라고 지정됨; 역방향 서열 GAGAAGTTGAACAGCCGGAT, 본 명세서에서 서열번호 15라고 지정됨; 프로브 서열 TGATGAAGAACAGCTTGAGCCGCT, 본 명세서에서 서열번호 16이라고 지정됨)를 사용하여 표 7 내지 표 38에 제시된 RNA 수준을 측정하였다. KCNT1 RNA 수준을 RIBOGREEN®에 의해서 측정된 바와 같이 총 RNA 함량에 대해서 정규화시켰다. KCNT1 RNA의 감소를 미처리 대조군(untreated control: UTC) 세포에 대한 KCNT1 RNA 수준의 백분율로서 하기 표 1 내지 표 6에 제시한다. 각각의 표는 개별 검정 플레이트로부터의 결과를 나타낸다. 'ND'는 UTC %가 실험 오류로 인해서 특정 실험에서 특정 변형된 올리고뉴클레오타이드에 대해서 정의되지 않음을 나타낸다. 그러나, 실시예 1에 정의되지 않은 것을 포함하여, 선택된 변형된 올리고뉴클레오타이드의 활성을 실시예 2에서 성공적으로 입증한다.
실시예 2: 시험관내에서 인간 KCNT1 RNA에 대한 변형된 올리고뉴클레오타이드의 효과, 다회 용량
상기 실시예로부터 선택된 변형된 올리고뉴클레오타이드를 SH-SY5Y 세포에서 다양한 용량으로 시험하였다. 20,000개 세포/웰의 밀도로 배양된 SH-SY5Y 세포를 하기 표에 명시된 바와 같이, 전기천공에 의해서 다양한 용량의 변형된 올리고뉴클레오타이드로 처리하였다. 대략 24시간의 처리 시간 후, 총 RNA를 세포로부터 단리시키고, KCNT1 RNA 수준을 정량적 실시간 RTPCR로 측정하였다. 인간 KCNT1 프라이머 프로브 세트 RTS39508(정방향 서열 GTCAACGTGCAGACCATGT, 본 명세서에서 서열번호 11이라고 지정; 역방향 서열 TCGCTCCCTCTTTTCTAGTTTG, 본 명세서에서 서열번호 12라고 지정; 프로브 서열 AGCTCACCCACCCTTCCAACATG, 본 명세서에서 서열번호 13이라고 지정)을 사용하여 표 39 내지 표 42에 제시된 RNA 수준을 측정하였고, 인간 KCNT1 프라이머 프로브 세트 RTS39496(정방향 서열 CAGGTGGAGTTCTACGTCAA, 본 명세서에서 서열번호 14라고 지정됨; 역방향 서열 GAGAAGTTGAACAGCCGGAT, 본 명세서에서 서열번호 15라고 지정됨; 프로브 서열 TGATGAAGAACAGCTTGAGCCGCT, 본 명세서에서 서열번호 16이라고 지정됨)를 사용하여 표 43 내지 표 60에 제시된 RNA 수준을 측정하였다. 각각의 표는 개별 검정 플레이트로부터의 결과를 나타낸다. KCNT1 RNA 수준을 RIBOGREEN®에 의해서 측정된 바와 같이 총 RNA 함량에 따라서 조정하였다. 결과를 미처리 대조군에 대한 KCNT1 RNA의 양의 감소 백분율로서 하기 표에 제시한다. 각각의 변형된 올리고뉴클레오타이드의 반치 최대 저해 농도(half maximal inhibitory concentration)(IC50)를 또한 제시한다. IC50을 엑셀 데이터의 로그/선형 플롯 상의 선형 회귀를 사용하여 계산하였다. 일부 경우에, IC50이 신뢰할 수 있게 계산될 수 없는 경우, 그것은 N.C.(계산되지 않음)라고 제시된다.
SEQUENCE LISTING
<110> Ionis Pharmaceuticals, Inc.
<120> COMPOUNDS AND METHODS FOR REDUCING KCNT1 EXPRESSION
<130> WO/2020/190740
<140> PCT/US2020/022680
<141> 2020-03-13
<150> US 62/884,501
<151> 2019-08-08
<150> US 62/819,344
<151> 2019-03-15
<160> 2939
<170> PatentIn version 3.5
<210> 1
<211> 4782
<212> DNA
<213> Homo sapiens
<400> 1
agggcaacgc gagggaagaa ggtggcggct cccactcgct tctccctcgg gtcgggtccg 60
agctgccagg ccgcatgcca ctccctgacg gggcgcggac cccggggggc gtctgccggg 120
aggcgcgcgg cgggggctac accaaccgga ccttcgagtt tgacgacggc caatgcgccc 180
ccaggcggcc ctgcgcgggg gacggcgcgc tcctggacac cgccggcttc aagatgagcg 240
acctggactc cgaggtgctg cccttgccgc cgcgctaccg cttccgggac ctgctgctgg 300
gcgacccgtc cttccagaac gacgacaggg tccaggtgga gttctacgtc aacgagaaca 360
ccttcaagga gcggctcaag ctgttcttca tcaaaaacca aagatcgagc ctgaggatcc 420
ggctgttcaa cttctccctg aagctgctca cctgcctgct ctacattgtg cgcgtcctgc 480
tcgatgaccc ggccctgggc atcggatgct ggggctgccc aaagcagaac tactccttca 540
atgactcgtc ctccgagatc aactgggctc ctattctgtg ggtggagaga aagatgacac 600
tgtgggcgat ccaggtcatc gtggccataa taagcttcct ggagacgatg cttctcatct 660
acctcagcta caaaggcaac atctgggagc agatcttccg cgtgtccttc gtcctggaga 720
tgatcaacac tctgcccttc atcatcacga tcttctggcc gccgctgcgg aacctgttca 780
tccccgtctt tctgaactgc tggctggcca agcacgcgct ggaaaacatg attaatgact 840
tccaccgtgc catcctgcgg acacagtcag ccatgttcaa ccaggtcctc atcctcttct 900
gcaccctgct gtgcctcgtt ttcacgggga cctgcggcat ccagcacctg gagcgggcgg 960
gcgagaacct gtccctcctg acctccttct acttctgcat cgtcaccttc tccaccgtgg 1020
gctacggtga cgtcacgccc aagatctggc catcgcagct gctggtggtc atcatgatct 1080
gcgtggccct cgtggtgctc ccactgcagt tcgaggagct cgtctacctc tggatggagc 1140
ggcagaagtc agggggcaac tacagccgcc accgtgcgca gacggagaag cacgtggtcc 1200
tgtgtgtcag ctccctcaag atcgaccttc tcatggactt cctgaacgag ttctacgccc 1260
acccccggct ccaggactat tacgtggtca tcctgtgccc cacggagatg gatgtccagg 1320
tgcgcagagt cctgcagatc cctctgtggt cccagcgggt catctacctc cagggctctg 1380
cactcaaaga ccaggacctc atgcgagcca agatggacaa tggggaggcc tgcttcatcc 1440
tcagcagcag gaacgaggtg gaccgcacgg ctgcagacca ccagaccatc ctgcgcgcct 1500
gggccgtgaa ggacttcgcc cccaactgcc ccctctacgt ccagatcctc aaacctgaaa 1560
acaagtttca cgtcaagttt gctgaccacg tggtgtgtga ggaggagtgc aagtacgcca 1620
tgctggcgct gaactgcatc tgcccggcga cctccaccct catcaccctg ctggtgcaca 1680
cgtcccgcgg ccaggaggga caggagtctc cggagcagtg gcagcgcatg tatgggcgct 1740
gctccggcaa cgaggtgtac cacatccgca tgggtgacag caagttcttc cgcgagtacg 1800
agggcaagag cttcacctac gcggccttcc acgcccacaa gaagtatggc gtgtgcctca 1860
tcgggctgaa gcgggaggac aacaagagca tcctgctgaa cccggggccc cggcacatcc 1920
tggccgcctc tgacacctgc ttctacatca acatcaccaa ggaggagaac tcggccttca 1980
tcttcaagca ggaggagaag cggaagaaga gggccttctc ggggcagggg ctgcacgagg 2040
gtccggcccg cctgcccgtg cacagcatca tcgcctccat ggggacagtg gccatggacc 2100
tgcagggcac agagcaccgg cctacgcaga gcggcggtgg gggcgggggc agcaagctgg 2160
cactgcccac ggagaacggc tcgggcagcc ggcggcccag catcgcgccc gtcctggaac 2220
tggccgacag ctcagccctg ctgccctgcg acctgctgag cgaccagtcg gaggatgagg 2280
tgacgccgtc ggacgacgag gggctctccg tggtagagta tgtgaagggc taccctccca 2340
actcgcccta catcggcagc tccccaaccc tgtgccacct cctgcctgtg aaagccccct 2400
tctgctgcct gcggctggac aagggctgca agcacaacag ctatgaagac gccaaggcct 2460
acgggttcaa gaacaagctg atcatcgtct cggcagagac ggccggcaat gggctgtaca 2520
acttcatcgt gccactgcgg gcctactaca gatcccgcaa ggagctgaac cccatcgtgc 2580
tgctgctgga caacaagccc gaccaccact tcctggaagc catctgctgc ttccccatgg 2640
tctactacat ggagggctct gtggacaacc tggacagcct gctgcagtgt ggcatcatct 2700
atgcggacaa cctggtggtg gtggacaagg agagcaccat gagcgccgag gaggactaca 2760
tggcggacgc caagaccatc gtcaacgtgc agaccatgtt ccggctcttc cccagcctca 2820
gcatcaccac ggagctcacc cacccttcca acatgcgctt catgcagttc cgcgccaagg 2880
acagctactc tctggctctt tccaaactag aaaagaggga gcgagagaat ggctccaacc 2940
tggccttcat gttccgcctg ccgttcgccg ccggccgcgt cttcagcatc agcatgttgg 3000
acacactgct ctaccagtcc ttcgtgaagg actacatgat caccatcacc cggctgctgc 3060
tgggcctgga caccacgccg ggctcggggt acctctgtgc catgaaaatc accgagggcg 3120
acctgtggat ccgcacgtac ggccgcctct tccagaagct ctgctcctcc agcgccgaga 3180
tccccattgg catctaccgg acagagagcc acgtcttctc cacctcggag ccccacgacc 3240
tcagagccca gtcccagatc tcggtgaacg tggaggactg tgaggacaca cgggaagtga 3300
aggggccctg gggctcccgc gctggcaccg gaggcagctc ccagggccgc cacacgggcg 3360
gcggtgaccc cgcagagcac ccactgctac ggcgcaagag cctgcagtgg gcccggaggc 3420
tgagccgcaa ggcgcccaag caggcaggcc gggcggcggc cgcggagtgg atcagccagc 3480
agcgcctcag cctgtaccgg cgctctgagc gccaggagct ctccgagctg gtgaagaacc 3540
gcatgaagca cctggggctg cccaccaccg gctacgacga gatgaacgac caccagaaca 3600
ccctctccta cgtcctcatc aaccctccgc ccgacacgag gctggagccc agtgacattg 3660
tctatctcat ccgctccgac cccctggctc acgtggccag cagctcccag agccggaaga 3720
gcagctgcag ccacaagctg tcgtcctgca accccgagac tcgcgacgag acacagctct 3780
gagccagccc tgcacggagc tcaggccacc aagcccgggg tcctcaggaa ggacgtggag 3840
gagcgtgtga ggacacggtg gcactagcgt gaccctgggg atggcacact ctactcacca 3900
tggctcctgg gactccaccc tggaaaggag cccctcatgc ggggggaggg ccagctcacc 3960
cctgggcacc tgcaggctag tgaggagagt tttttaacct atttttacac gtcgatgcag 4020
tccacttctc tttacacaga tgtaccgcaa ctcgtgacca gggctggctg ggagggcaac 4080
gcagggactg gacgccctac agggccgagc ccaggctgtg ctggagggtg gggctggggt 4140
gcatggggag gggagcagaa cccagaaccc aggagccccg cgtgggccac acccaactca 4200
gagccggcct gagcgttcac ggccaggcag cctcgcttcc ttgcagccaa gggctggggg 4260
ccagggctgc tgttctgcac tctggggtgg gtgaggggga ccctgggctg tttgctgtcc 4320
caagcccctt ctggaagtta gaagcagcaa agggcccggg gaagccgggc atgtgagagg 4380
ggtgcgtccc caggtccccc agagggccct gtcgccgagg acctttctga aggaagcaga 4440
agacgccatt tcctctactt cacactgaac tgtcccagcc actgcatcta gggggcattg 4500
ggcggaagat ggtgcatttc catggaccat tttacactta ccttttaaag caaagcctca 4560
ttttctaaac ccctgacttg tgaagcacaa ttcagcctcc gggctgggcc acgtggagag 4620
agaggatctt ctcagcaagg cgagatcccg ggcggcggct gacatcagga gcgccaccct 4680
gcgtcctttg ctgctggttc cttactggtt tgtacggtca gcgctggaaa cttctattaa 4740
atggatgcat tctggaggca tgaagttaaa aaaaaaaaaa aa 4782
<210> 2
<211> 98000
<212> DNA
<213> Homo sapiens
<400> 2
tctagggggt gctcagccag ggaggatcag gagaccccaa ctctccccca aattggcacg 60
gagcatctcg gcaacccatc aatgaacagg actcaggggc acaggagggc tggaaaggaa 120
ggcttgctcc tttccaggaa cagaataaca acaggtaagg cttgaacaaa tcaggaagtg 180
ccctgccgaa aacgtggcct gctctagccg tggagaccca gagggctgaa ggagacgggg 240
atgacagggg acacactgcc tgcaaggtgg tgagatgtcc catcaccgtg atgccggagg 300
actgacggcg tctaccctta caactcacag cgtgctgctc ctgactgggc cccagggcgc 360
tggcaagccg caggaactgc acagacatct ccaggaccga ggccatgtcc tcccgccggc 420
catcgaactg gggcagcagg gcccgcagac gctcacagct caacgacatc cgcttcctgg 480
ttccggtcaa gaaacaaata cctctgggcc ctcctgccct ccccgagaag ggacagcaac 540
tgctagaacc tgccagatag accctgggcg cttgtcaggc agagggggct acaagatgac 600
tcagagctgc ccccgtggtc tgaagccccg agatccacat cagagcacag cctgggcctg 660
acccctggac ctcggcgaca ggctgtccag cccaggccca aaccatggct gctttgcggt 720
gtggaaaaga cagcgagggt cagaggcagt cagaagcaca gagggtcaca ggtgcacagc 780
ctcaagaggc caaggcttca ggataaagag gggctgcagg atgttcccca acagggcttt 840
tctggtttac ttggagatgt gcagtctgtc cttctcctgg gcacaggcca cgagcccctc 900
ccagctgcct gacacctggt ggcagccccg aacataatct cacccgctcc acccctttac 960
agcgccctca cccctgggag gcaccaccac tcacctgcgc tccctctcgc tgatcacgtt 1020
ccgccgaagg caggagctgg gaccctcggc caccgtaggg gccttgggcg ggcccgagcc 1080
ccgggccgag tcctcgcagc aggagagggc accagacagg gagccgctgc cgagaaagcc 1140
aagagcaccg ggccctgaga accccagaaa aggccaccag gagtcccaga tgccagaatg 1200
ggcgtctttg gggtgcgggt ggaagccaag actgggtcac gtagggacac ggcccggccc 1260
tctctgcacc ccttcccctc tcccagggtc cagggctccg ccccaggagg cccaggatgg 1320
gtggagccca gcaacttgcg gaagaacccc tgggtacagg ccttgggccc ccaacccctt 1380
ggccgccagc ccaattcctc acttgcatcc cctgacggta gggattctgg agacctccgg 1440
gtagggctcg gagcaccggg acgccatgaa ctcgcagctg cggagcgacc ccacgcgcac 1500
ggccccttcc gcaggcagcc ccgccccctc acgtgtgctc tgcccacctg ccacgtgctt 1560
tccacctagc ccaccccacc cccacttgca atccgccccc atagcgcatg cgctctagcc 1620
ctccccacgc agccagcccg gggcccacgt gacccgcgtt cctgcaaaga aggtgctgga 1680
aagggactcg gggggtccac ccactctatg cccccgcagg acgccagggg aaggggcccc 1740
agcccaggtg gccctgcctc tacccttacc ttcccggggg tcgcctcggt tcccacttat 1800
gcggtggtct cggtgccctt gggcactttg gagatgcggg ctctgccctt aggagcccag 1860
cccctggtgg gagtgggcgg gctgggctga gttgtttagc ccaggcctgg gggacccagg 1920
gacacaggga gggggaaggg tacccgcctg ctccccagtc gcccacgcct ccattttccc 1980
ccaaatctag tacgcttgca gacgctgcgc ctcagggtag ggtcaccatc cacacttctg 2040
ggtcgcccag aaccaggggc atcttgtccc caccccaggc caccatcgtc cgtgctcttc 2100
ctcccgctga gctctgccgg gcaccctcgg aaccgtctgt cccttcacct ggccctgccc 2160
aagcaccatc cccgctttat gccctggggc cccagctcga cccctcacct cacactctca 2220
acaggtttct gcgggatcgc gggggtcctg cccatccaaa ttcagaaagc tccggcgcca 2280
ggtgtttgct cacctccccg ctgaactcca ggagccgccc tgcgctgggc ttgagtcccc 2340
cagtacatac ttttgggggg atgacggagg gaagggggag gtggagaccc ttcctctttc 2400
acggaggttg cggggggccc tcagggaagc agaggggacg agggtggggg gtgaggctgg 2460
actgttggga ggacatccct ggcctggctc gtgctgaggt cgtagcggga ggaggtgggg 2520
tgggtggcag gggctctcct cccgagaggg gaggcaagaa ggagcccggg caggtgccac 2580
cacacgggga cgtctgtccg gggtgcccca gtctcctgtg gagaaggcgc ggctctgggc 2640
ctcgggctgg catcctggac tttgggccaa agatgggtga agggtgtttg gagcagaggg 2700
aggttatgta atataaggtg gtgtctccat ccctgctccg cccagccttg gctgcaggtc 2760
agacatggag gaggacgggg ttggagagga gggcaaaagc tctcggggac ctgggcccct 2820
ctcccggccc tgcccctggc cagggaggga tggacgggct ggcgatctgg ggctcctcag 2880
tggcagagtg gggccaagtt tttgtttccc taaagccctc ggaatgtcat caaacctgtg 2940
actctcctgc cgttgacaac acgtgtaatt actgctaatt aatcacagat gcagatggtg 3000
cggcctctca gttttttctg agttccccag gcaggagggc gttggcagaa aggccaccat 3060
cttgccccgg cggcacccgc ccaggggtgg tgggaccccg gcagcagcac cggccaatct 3120
agggacctga ggaaaaaccc ccaagatgcc cacgagctgt gtggcggggg cacaggctga 3180
acctctgctg gggacttagc atcctagact tccccgagtg ttccccaccc acccctcaaa 3240
agcatctgtg ttcagcctgc tgcctcctgg agaaacaggg aaggaccctc tggagagaca 3300
ctggggaggc cagggaccac aaagtacatg gcatgcgccc tccaaatgga cctggccctc 3360
cccctggccc tcgtgggcac agtcctggct tagtgagggg cctggtccac cctgcaaacc 3420
aacaaagctc tggggacaga aatcgcagtt ctccagagct ctgtgtgagg ctgagccagg 3480
gtgacgcatg tgtaacagtg tgagcacgtg cacgggaaag ggggcccgca gggggaccct 3540
ctgcttccta gtctttggcc tgcagcatct taagttgggg cccctcccca cccgtctaaa 3600
ggtgctgtgt gtgcccgtct gggtgagagc acagggcggg gtgcagtcat ccccctcccc 3660
caggccaagc ccaggatgtg gcgcccaccc acagatgccg cagcctgcgg ggggtgtggg 3720
ggcggggggg cggggagtcg tcttgaatct ggcttgtgtt caatgaccag tgttgaccac 3780
ggcagagcag cacaagcggg aggtgctgac ggtccctggg cgcagcggct ggacgctggc 3840
ggtccgagca gcgcatgtgc cctgctgccc gccaaggacc cagagccccc tgagcccccg 3900
cccaccacgg agccctccca ggggtgtagg gcccggtggc ggcgcgcttg ggcttttcta 3960
gccattgacg aaccccgtcc tgtttttcgg agttttgagg gctcagaggg ccgcggcggg 4020
agcggatcgc cctccctacc ccgcaccccc gtcccagcct gggccagagc cgccgcgggt 4080
cccggcgcgg ccggcagggg gcgcgcgcgg acagacgcct gcacccgacc ctggaactgg 4140
cgtcttttcc tcgctaatct gcgaggaaaa aaaaaatgtt tttcagggca acgcgaggga 4200
agaaggtggc ggctcccact cgcttctccc tcgggtcggg tccgagctgc caggccgcat 4260
gccactccct gacggggcgc ggaccccggg gggcgtctgc cgggaggcgc gcggcggggg 4320
ctacaccaac cggaccttcg agtttgacga cggccaatgc gcccccaggt acagtctgct 4380
gcgccctccc cacgcgggga ggccccggtc taacctaaga cccccaagtt ccccctcagg 4440
ctcccgcacc ctccaggacc cgccattccc agggccatcc aacttcccca ggacccgcga 4500
gtgccctccc aaccaccttg gggaacaggg gcgcccctca gggtgggccg cactaatcag 4560
caggtgccga ggcagcagcg tccgtcccca tctgtcctcg acctggtaag aagctggggg 4620
gagcggccgt ggctacatgg gggtcctgag catctcccag gtgtggggag tggcagggag 4680
gctgggggcg gtgcagggcc ttccatctcc cccagcccct gccccacccc agcttgggga 4740
ggaaggttcc atccttcttg tgtggcatgg cagtgctcgg ccagggtggg gtgcccggcg 4800
aggttacccc acacagtagg gggtttccag agcaaccttc caaggaagag tccccagtgg 4860
gaagtgggct aagtggctgt cagatgaggg cgggagtcct gggttctggt cactcctcgt 4920
tccccgctgg cctatccctg ggaggagagg gccagttgag aatggcattc aggtgacctg 4980
gagctagctg ttccctgtgc agtgtcctgg gatgccatgc gtctgccgtc cacccagtga 5040
ccagtgcaga ggcacggacc ggcagctgag tgggacagtc ctgagcggag gttgccccag 5100
ggtccaggtt ccccatcctc tcccccatcc ctcagctctt gaaaacaggc aagtctgccc 5160
ctcaccctgt ccccagagcc agactccagg gaaccctggg cagagccggt cactgccttg 5220
ggcgaacccc tccccaccag gacagagccc tttcttctgg atcctgccca gtctcaggct 5280
gtcctgaggc cagagaaggg ggtggaagag catacctgag agcgggaggc ctggtgcggc 5340
tgcctgtttg ttctatggga ctcagtttcc ccgagtgtaa aatgaggagg tagggcggat 5400
ggtctttaag ggctgcctct ggtgagggac caggctggag aggaggttcc cagaatcaag 5460
aggcaggcac agcacccacc tggcacccgg gggagtccgg ggtacagcgt gtgtgaggag 5520
caggtgctct gagggtggac agtgacttgg tgatgtcctt gggaagtggg cacagcctgg 5580
acgtgctctg agggactatc cgggggatgc ctgtcaggca cagagaaaat gaccccaagg 5640
gggtcctgga ttgccctcat ctttgtgggc tggccggccc ctaccatctc cctccccagc 5700
ctagcgttgc cctccctggc cattctgctg gagtttatca cctaccctgc tgggcctgac 5760
ctgctccaga cgagccggca ggacagtgtc ctcagggtcc agcctttagc tccaggcctc 5820
atcctccggg tccttccaga cacctgtctc tcccaattgg ccctgcccac cggcccggga 5880
cagctcctcc tccccgctgg actgagctgg cctccgttgc aacagagatt ccctgtcaca 5940
ctgcaggcag agcagccgcc ggcagtggag ggatgtcagg cgtcaggctt ggggagggag 6000
caggacctgg gcttggctgg gctcgggagc ggggagctga gctccaggtg aggccaaggc 6060
ttgcggccca ggcaggtggc ttcagctgca gaaagaagaa ccttcgtgct gcctggtggt 6120
ggggggagct ctgtggggcg ggtttcccca ccagctctca catggggagg agggtgccag 6180
gcaacagcgt ggtcagaacc caggccctgg agtccatagg tcttggtgcc aggccttgag 6240
caggcctctg tctttcctgg gtgctggagg atgccagcct tggtgctatg gttcagaggg 6300
gccaggaggt gcttggacac cccaccccac tccagtgccc cagctcaaac ccccagctcc 6360
acgctagtgg tgtccctgag tcagcctcaa ggccatcagg ccggaaagtg gggctccaga 6420
gaggagctcc tggccttcca gtttgcaggg gtcttcacgg gcctctggcc tccaggctcc 6480
ctgctcccac ctccatgcca tggagtccca ggccctcagc tgcctcccca caggccctgg 6540
agatgacagc tgttgtagga cagggaggga ccagtggccc tggtggcccc agagctggca 6600
agtgcccacc ccctgcccag cgcacttcgc atcagagccc ctgccaggcc tttcctggaa 6660
ataccacttc ccagcagctg tgctccaggg cgggcctggg accctctagg ccctgatggg 6720
atcaggccct ggcatcctgc cagggtacat gcctggccca aggtcctggc cagccctcca 6780
ggcccatatt agggagcagt gccttcagca gcaggaagta gctcagggct catgggaaag 6840
gtttgagggc ccaagatacc gcccagcact ggccggcagg agggacggct caggccacag 6900
ggaactcagg ggtctgctgt ggcccaggag tggccacagt aacagctcag gaggacagag 6960
gtgagtgaga agggagcaga cagggtcccc acgagggcct ctgcttctgt tccagtggct 7020
ggcctgggtg tggcctgtgt cctcgcaccc ggcagcctcc aagtgtgctg gtctggttca 7080
cccaccgtat ggggagctct tgattaacac agaaaattac ttgggacgag cctggtgtgg 7140
cagtagtggg gccttgctgt ggggccatct catgccctcg gagggtgttg gggggcatct 7200
cgggctctcc cctgaggctt tttgtcctgc ttccccggga tgcaaacttg caggctttga 7260
cccaggtgcc atcggccctg gaaagggtgg cacttctgtg tctcccacaa acaatcccag 7320
gtttctctgc aacaggaaag tttgtccaag tgtgtcccag ccctgcatgg gtgagggatg 7380
ctgaacgggt atcgtgtacc caaaaacaag tgctgtgtgt gcatgtgaac ctgggcgctc 7440
cgtgagccag gcaggcgcac cgtgggcacg tgtgtgagag ctggaggagg atgtgtgggg 7500
cccgccagcc agcttgtgtg accttgaagt caccggtcat gagtctgggg aaaggcaggc 7560
tgggctcagc gtgcccgtgc taggtggctg ggtgccaagg cccggttaaa tgggcatctt 7620
tcaaaggtgt cttgggacct ctcccagctg tgtgtgtgga taaggccacc catgttcacc 7680
cagacccact ttcacctgtg gaacttggaa gtgagccagc ggggctggaa ctgaggccag 7740
gatgcgattg gcccagggag gtgagaccag tactagcagc tggcaagtgt aacaggtttg 7800
caggggacag tggcagggca gaggccgcga gcttcctggg gtaggtccct gggaaggccc 7860
tccttgagag ggggcctcca gctgctccct agatcggggg cgggaggtgg gggaggtggg 7920
agaggagggt ggcctcactg gagcagaggt gggggcatca ggagatggag ggcattgcag 7980
gaccagggtc tggactggca caaggcgggc gccccgggag gagcagaggg cctggaggag 8040
cttctgggaa ctgtgtctgt gaggttggtc catcccagca ctgagatgca gtagctgtgt 8100
cagctctggc gagtcacttc acctctctgg gcctcagttt cctcatctgt agaatgggag 8160
tgctagcatg gaccttacga ggttgtgttg agcccatgct gacagcacat acttggtgtt 8220
tacaaagctg tgttggcgtc gggagcttgc acaccagcca gttcgtcttt gccttgtcac 8280
gcaccagcct gtgttgacac gtcagagcta agcatttgtc cggtgacttc ccaagatgga 8340
ttcttaaaag tggaattgcc cagtcaaaag attcccacag tgttaatgtt tgccgcatgg 8400
cccacggccc ccaggggtga gaatggctcc tcctcacaac agtgccgggg tgtggtgtgt 8460
gccagctgcc accgtctcct ccttggcacc gtcgccctgg ggcacctgtg tcctgccagg 8520
caccactcag gcctcggagg ctgagacaca gctggcccct tggtgcccag gaaaggcaca 8580
caggcctcct cctttgtagc cactctgggg cactccacaa gaggggcaaa gagggcttcc 8640
atctgcctgt gactccctcc aggggccaga agtgggtcct catgcttcac aggcaccaat 8700
agtgcttttg cctggggcag accccagctg tgacagacag ccagggctca gaccaccaca 8760
cccagcagct ttccagtaga ttttcctgac cccagccaca ttgagggagg gggctggggc 8820
aggtattggg agcgccagtg agttggtcat tttctgagca tgatggcagc tcagggtacg 8880
ggcccctaga tggagcaggg gccctgtgcc tcagcctccc taaagtggcc cagccctccc 8940
agagttcatt ggtgctgagg aaatgaagcc tcacttgtgc ctcagttccc agacaggccc 9000
aaggccaggc acggtgggtc atgcctgtga tctcggtgct tttggaggct aaggcgggag 9060
gattgtttga ggccaggagt tggagaccaa cttaagcaac atagcaagac ccctgtctct 9120
acaaaaaaaa aaaaaattaa aaattaagat cagataaggc ccggtgcacc cctgcaggcc 9180
atgccagccc tcaggtgctc agcatggcca gcccagggac ctggcacagt tctctggggg 9240
aatgagcagg ggcatggtgg tgcctcccat agctgtggga gaggggcggc ttctcctcca 9300
ggtgcagccc ccaccacggc ctccccaccc tcaggctgtc caccctagga gggctgtccc 9360
caagggtccc ctgccggctc caggctgtgc tccttgctat gatcaccatt gcccccagca 9420
gccagctcag ctcgagggta ctgacagctg acgtgtgcag tcactaagca tctcccagca 9480
gccacagcgt ggccgggggc aggggctgtg ggccgatgca gctggagaac agggtgtggc 9540
ctgtgagaag gaccagccaa gggtcctggg cacccagggc ccaggaccct gagatggact 9600
tgccatctga ccctgagtga ccagcacact gctgcctgct gcagggggtg gggacagcag 9660
aagggctcgc ctggcgtctg gcccaagccc aggcttctgc ctcccccgac aaccttgggc 9720
acgggtccag gggtgatggc ccccacagcc tcgcctgggg cccctgtgtc cactgtgctg 9780
ctggccttcc cctcttcccg ccgggctggg agaaagctgc tctgaagtct gtctggataa 9840
atctacagct tgatttcggc tcctccatgt gttctgagct ttcactttgg atcctaaagc 9900
atctcaggag atggtgctga gcagccaccc tcgcatgggc aagaagcccc tcccctaaag 9960
agagacgtca ccgaggacgc ttgcctgccc agctgcctgg gcatctcgag cagctctgac 10020
tttttaatca tcgtgcaaag gaagcgttga gttttctgcc atggtcagca gagaggttct 10080
gcagctttgc acttgctgga cactaagccc agcactcaga cacccccacc acagtgatgc 10140
tatgcctgcc tgggggactc tcctggatgc agggtaggga tgcccacaca catacaggca 10200
catgcacaca gatccatgtg catgcacaca tatgtccaca tgtgcacatg tatacatatg 10260
cccatgtaca tgtatgcata catgcacatt gtacatacat gcatgcaatc ccatccacac 10320
atgcatgcac atattcgtac acatgcctct gcatgcaaat acatgctcat ttacacacac 10380
atcagcatgc atgtgcgtat ttacgtgctt acatgtgctc atctccctcc tccctaactt 10440
ctctgtcaaa catggctcgc ccagctcctg gaaattttga actgagtgtg aacaagaatg 10500
tattttagga gagaaacctc attcccttag ccaaagacag tcacaatctt tttttgttgt 10560
tgttgtttca gacagaatct agctctgtca cccaggctgg agtgcagtgg cgcagtcatg 10620
gctcaccgca gcctcaacct catgggctta aatgatcctc ccacttcagc ctcctgagta 10680
gctggaacta caggcaccat gcctggataa cttttgttat tttttgtaga ggaaggtttt 10740
tgccatgttg cccaggctgg tcaggaactc ctgggctcaa gtgatctgcc tacctcgggc 10800
tcccagaatg ctggaattac aggcgtgagg caccatgctg gaccacaagc aatgttaaga 10860
gaagtctttg cgggaaagga cattttatcc aggacttcct atgctgatcc tgagaggcag 10920
gctccttgct tctttctgag ccccacccgg ggcagaaata agggcctggt gatgctggag 10980
tttagggaag gacatcttta gcccttagct gttccgtttg ccataacaca catcgtgcat 11040
gatgtattca ctttgcaaag cacaatgggt gagacgctgc cctagaaccc caccctgccc 11100
ccagcactgt ggctgccagt gtgtggggac agtctctata tcacctacaa gctgggtgcc 11160
cagagaaacc cacctcttct ttagggttct gtggaaagcg gtcgtgttta gtttttaaat 11220
ggggttcatt atatgccatt ctgtttgtgt agtgatgcat ccacacgggc tcacgcaggc 11280
tcacagagac ctgtgccttc acagagcagt cttggctgta gctgtcagtc gctcctcagt 11340
tcagggacgt gcaggctgtt ttcagtgttc accttcacac atgaggccgt gatgaaaatc 11400
catgcctggg cctcctcggc cacagatcaa aaatgtcccc aggtagaggt tccaagttgg 11460
agaggaccca cgattccatc ataattaatc cactgctccc agtcggctgg acactacatg 11520
agagccctgg cttgcagaac cccccgttct gtaaccacag ccgatcactg gcgcaggaga 11580
ccgtccaact ctgcatctct ctaattatta gctaggtggc ttgtctttac ttgtgcgttg 11640
ttttccattc ctcttctttg aacctcactc atccatcctt tgagtcgttt tcttttttga 11700
gatggagtct cgctctgtca cccaggctgg agtgcagtgg tgcgatctca gctcactgca 11760
acctccgcct cctgggttcc aacaattctc ctgcctcagc ctcccgagta gctgggatta 11820
taggtgtgtg ccaccacaac cagctaattt ttgtattttt agtagagatg gggtttcacc 11880
atgttagcca ggctggtctc aaactcctga cctcaggtga tccacccacc ttggcctccc 11940
aaagtgctgg gatgacaggc ttgagccact gcacccggcc atgttttctg ccagattgtt 12000
ttcctttcca cgggacctgt aggcaccagg ctgtgttctg atgattattc tgttgcaaat 12060
atgttcttcc tgttggtcgc ttattctttc cttttgccag tgatgtcttt tgttaaacag 12120
cagtgttttg ttcagatgta gaagctttta taaatctatt cctcttggaa tagatgattt 12180
ttgggtttcg tgtattaaat aaaaggcctt ctcagctctg aacacttttc cctgtatttt 12240
ctttccatct tgtccttggt ttggggctgc agatggggtc taatcttatt ttatccaaca 12300
gaagacactg catagcatag gctggagcca ggtactgggt tcaagcaccg gccctcccaa 12360
ggcaagggga caagtgataa acaaggacaa ataaggaaca aggtcaagtg catttctgaa 12420
gttctccggc ctccatttct ccatcaacac aatgggaagg atgtcgcccc tcctgatatt 12480
tgcaaccgtg acttgagtca ggacaggtgg agctgcactc gttccaatac cataggacga 12540
ggagtgcccc ccgcctcctt tctcaagcct ggattccaac gtgggcttca gctggtcaag 12600
gcactctgct gtgtctcccc actctctgtc ttttcttggg ccagaccgca gagtgtcagc 12660
tgctgtggct ggacattggt gctggcagca gaagacgagg gccctctctg ttccttttca 12720
caactgctgt ggctgttctt gcacgtatag tcttcaggat taatttttga aacagttcat 12780
caaattctga gaaaatagtg atgcgctctt gattggcggc gattcccttt acccgtgtgt 12840
ttggagaagg gactgttaga ccctcaggaa gaagacctcc gtcttccgcc agcgacagct 12900
tccagtccat ctctcaggaa cgctgtgcgc ccctgtgggt ttggggctcc cgcgcctgct 12960
gtgagcaggg ctttctcccg gtggctctct gctcctgctc tccatggtgc tcctgggttg 13020
gccgccatac taggttccgt atttgctcta gtaggttttc agttgattcc tcttgggttt 13080
tccagtaagc aatcatgcca actccaaaca gagccccctt catgactcct tgcttttatc 13140
ctttttctcg cagcagtgca cagatgaggc ctcctttatg atggcaaggg cagcctcaca 13200
ttcccaactg gaacgggaat gcccagagcc tttggcggga gaagcttgtc tttaagcact 13260
ttgtcagaca gccctggctc catggccacc gggaacagat gcagggggag tgagaagcag 13320
gcactcctgg ctatcagaag agccccccag ctggccaaag gcagcacagc ccaaggtgaa 13380
cctggacctg gcccccaccc cagtgcctct gccgggacct cagtgacgct ccttgggctc 13440
tgggagccac ttgtccttgc caggaactag ggatggagac tggcttctga gaactgttct 13500
caggattcca tgccaccacc tggcttgcca gggtgcctgg cgtgcagctg gctctcagtc 13560
catggcagct ggcactgagc acagctgccg ggctcccctc tgatggggtt gtcagggtca 13620
gtgcacgtga ctacgtgtgc accaaacagc tgacggggac ttcctgttgc cgtgcccagg 13680
tgtggactgc ctcgctcatt cttggcctct ccagatggat tccaaaagtc agtgtcccaa 13740
gcctgagctc tctgatgggc ctcagctgag cggagggggc acgctgggcg ccggccaccc 13800
tgggtcatag cctttgtcca taagagctca gccaaactgc tggccacgct acacctgctg 13860
tagctgaagc actcacctgc aggccctgtt ccgcgtgcct caggcatgct gtctggttac 13920
atcttcacac tcttcctata agggaacagg catcagtatc tcccttcacg catgagcata 13980
caggctcagg gaggtgaagt gactcgccgg gggccgccca gcaggactga tgggccagga 14040
ctgaactcat gccagcggga ctcttgccac tctctgggcc tgcagggtgt gtgctgacag 14100
cccagagagt ccccaagagg agcagcgggg tgctctgagc ccctgggctg ccccggcctt 14160
gtctaggggg tgtgctgtgt cccgtcacct cagccctggc tccaaggggt gtgtgagtcc 14220
cacaggttga gctccacacc ttgtccagag agtagtgtaa gggctgagga gagggacacc 14280
ttccttaagc caccaaacac agaattctta tggaaattgg taattatttg gcacagcagt 14340
cactcagaaa ataaaaagat catggatgtg gccttggggg tcctagattt cctccagggc 14400
cccttgggtc acacagggag gacagcgcaa gagaagaggg ggtgcagaat tcgaggtggg 14460
ccccagggtc cccgtgtctg gctatgccag ggttatgttc cagttccacc tgaaccagct 14520
tcaacaggga ccagaccccc caacactccc ctctccccct gtgcccaaaa aagctggccg 14580
atgtaggcct tcctgcttgc gaaaagtctc aaccagaccc cgaggacacg gggagcagct 14640
gttttgctgc tgtcctcctg cgatgggccc ctttcccaga gaccctgtag ccccggccct 14700
cagtcccagc cctcagccaa cacaacagcc aaggatttta gccccggccc tcagccaaca 14760
caacagcgaa gtattttcaa ggtttctggc tctgtggggg gaacaaggca ggatgccagg 14820
aggcctgcag gacacctgct tatggccgtg tgctcgctca agtgtcaaag cagcttccca 14880
agggaagaag ggcatcttgt ccttgtcacc ctccccaggc cacatctggg gagcaggggt 14940
ggggccaggt ctctggactc ctggtgcact tccttcccct ggtgactcct gaagcaagcc 15000
aaggtccaag cccctgagct tgtccatggg ccctgccaag actgggcctt gaggccagga 15060
ggaggaacca gagccgctca aaaggcagac ggggtgggga cgggaggagg cagccacgcc 15120
tgaggagccg gcagtctctt ggggttttgc cattgaaagg ggctttcagt gaggaaggca 15180
caaaatcaag aaaatagagc cccgacccct ggccacgtgg ttcccctgcc tgcctgcacc 15240
tccccatggc ccagccagct tgtgactaag gaaaaacatg cagctacgct gatgcagtta 15300
ggaaaatgtt attttttaaa tgctgccaga tcctgggggt tgaacctgtg acctcagaac 15360
aaggagcagg gtttggggca cgcacctgct gcctgcagct tcagcctggg gtgcccatag 15420
ctccttgcct gctgcttgtc tgagggttag gggacacagg agaggcactt ggtgggggct 15480
caaggaatgt gcccacccct cccgacttga ggagagagag gagagttttg tagcatccct 15540
ggacctggtg ttccaaatga gtggcctctg tgcagggcct acgggcacag cacggggagc 15600
tgggtatggt cagagcctcc tgcccctgcc cgtgggggag ccagccccct ccatcccccc 15660
tctgctctcc tgctggcctc gaagccttga acaagggccg gcctgggcca ggtaaggagc 15720
tccctgcccc tcagctcctg cttctcctgg agcagccaaa actcacttca gtgggggaca 15780
tggggacagg aaagatgcaa gacccctgga agacacctgc ttgggccccc aagaactgca 15840
gaccaccagg ggtcctccca ctctacctgg tgtgccacga tgcccctaac ctgcgctgcc 15900
agctctctgt gtccctttga tccctcacct ggtgacagtg gcagggcagc tcagggccca 15960
gagggcctgg cagccccccg gggttctgac ctgagctgag ctgctccgcc tggggaggct 16020
gcaaacaagg gtgtcttctt aggcctcctg gtcactccac cctcacccct caacagcctg 16080
agggtctgag acgggggtct ctggggctgg accctgaagg aagattgagc agccggcctc 16140
ggcaaagacc ctggggacgg ggaggggagc tggggagttg ggaggggttg caggggtgtg 16200
gcggggcttc agagcagggg gagggcctcc atcctggctc ttgggggatc agggaggagt 16260
ggtgcgcgcc tgtccctgag ctggccatga cagctcccgt cccccttacc tcctgccagg 16320
ccccggggcc gctttggagg gagccccgcc ccctgcccct gcgcagcccc cgccctagcc 16380
ccagcccggc gcagccggtc ccgcgcgccc ccgcccgcat gtgccgccag gcccgccccc 16440
gcccggccgc ccgcccgccc ggtgggtcgc ggtggccgcg ggctgcgctg cgcgggccgg 16500
gcctggcggg ccgggggctg cgcgcgtccg cgagggcgcc cgacgcgggc tgaggggcgc 16560
tggcgtgtgc ccgcaggcgg ccctgcgcgg gggacggcgc gctcctggac accgccggct 16620
tcaagatgag cgacctggac tccgaggtgc tgcccttgcc gccgcgctac cgcttccggg 16680
acctgctgct gggcgacccg tccttccaga acgacgacag gtagggaccg ggcgcggggt 16740
gggggctggg gtcgccgtcc cggcgccgcc gcacgcccgg agctgtccgc ggtgctgacg 16800
gccggtcccg cgcgcccccg cagccgccgg cgcccttcaa cttttcccgg cttctgggga 16860
cgcagaagtt tcggaggggg tgcgggcagg gggaagcatc ttctcgggag ggggtctccg 16920
gaggagggcg cgggatgctc ggagctgcgg agtcttccag agcccgactt ggggcgcgga 16980
ggcggagggc ggcctggcct tccggtgtct gctcccaacc cccagcaccc cagtttttct 17040
ggttttgggg gcaagccagg gccggaagcg ccccggtggc ggagcccgca gcctggctga 17100
gggctggcgt cctccaggct caggcagcgg tccttgatta attattcaat gagggagctt 17160
gtccttcagg ttcgtgacct ggtcacttat tccgagtcac cgtgtccccg tcccctcaac 17220
atctcctggg ctaaaaaggc aaaatgaatt gtgtctttca gttaaggacc aacaggatga 17280
gcccatggga ataattcatc cgctgagggg gctggcagga agctggaaga aatgttgctt 17340
ttctctcctc cttttcccca aatagctgtc ttgggtaaac acccagcact ttagctctgc 17400
caggctctgg ggaggcgctt ttttgcctgc aagtgaaggc aagtgctctg aggactcacg 17460
cggagctgga gcccgcgggg gcttcaggtc aggaaccgct cctcttccag cgtgtagggt 17520
acggcagggt cggggttgtc actgtctcca gggctccgtc accacccagc cctgggctca 17580
gctagcaaat ccgcactttc ccccaacaac gcagttattc cggttagcac acaaagtaca 17640
cgaggttgaa aatggtcagg acacaaacag ctttcagaat aatctactgc tgaaaccgca 17700
gctgaaaaag aaatcatgtt tgtaactaga gtcagtccta gggactgtat ccatgaggac 17760
catgaagatt tgtaaaaagg gggtcttaaa acccctctgc ctgcggggaa tggaatattc 17820
taccagacct cccataacat ttggttgtgt gaaccaagag tcaggagtgg ggactgagcc 17880
cagtcttcat ccactcagaa tcagggagtg agcgtcctgc agagaggcct tttaaacttg 17940
gtttttcatc ttgttgaact cagtgctcta ataatgagcc cacctaagtg caaatgccca 18000
ggtgaagagt ttagtttatc tccctgtgtg ggcagagggc agtcagccag gctggtccca 18060
gggcggcgtg cgtggctggg aggctctcct gggagccaca caaagcttcc ctaggccgaa 18120
tccgtggact caacatcttt ctaagccagc accagcccct cagatgcctg ttcagctggg 18180
acttggttaa ttcttgaaaa cggcagccct gggagatcct tccgatattg ggcaggaagt 18240
ggtgtccatc cgcctaatgg tgcctggggc tcccagatga ctcgataacg cctgtggctg 18300
tggttgatca aattgtaatg ctgtattcct gagtgttcag gagtggacag cagaggcttt 18360
tgctgtccgc ctagagagaa ccatgcccat ccctgggaga ggagaagctg gcatgggatt 18420
tcacaatgag tccctgatcc tgggtgtggt tttttaaaat tgtggtaaaa tacataaaac 18480
agaatttacc gttagtgaca tttagtacac aacactgtgc caccctcacc actgtaattc 18540
gagaacattt gtatacccta gaaggaatct ccttaaccac tgggactcac tccccaatgc 18600
ccccttatcc cccagcccct ggcagctacc gatttgcatt ctagcggtct tggcgtgctg 18660
tgcccactgg gcacatgggt tgtgtgccga tggtattagg aggtggaccg ctggacgtgt 18720
gtggctgtgt gtgctagcta gtgcgtggct gtgggtcctc tccaggaaag gcccatgggg 18780
tacagggcat ctgtgccacc cccacaagtg ccctgctctc tctggttgga aatgaagtat 18840
acagtgaggt tctattggag ggagagtggc cagggattag agcttcgggg ctgtgtggtc 18900
gccatacctg tcctgtggcg ctgtccctca agatggcctc agagatgctg tgctgcatac 18960
cttttctcat gtgtgaagga tgggagtgga cctggccctg tggtggtggt gtgcatagga 19020
cgggagggga cctggcccct gtggtgttgg tgtctatagg acaggagggg acctggcccc 19080
tgtggtattg gtgtctatag gacgggaggg aggggacctg gccctgtggt gttggtgtgt 19140
ataggacagg agggagggga cctggccctg tggtgttggt gtgtatagga tgggagggag 19200
gggacctggc cccagtggtg ttggtgtcta taggatgaga gggaagggga cctggctctt 19260
gtggtgttgg tgtctatagg atgagaggga aggggacctg gctcctgtgg tgttggtgtc 19320
tataggatgg gacagggagg ggacttagct tccctctgag agtggttccc cacttctcac 19380
ctctgagagg aagcttgggc ctggtggaga tggtggcctt gggcaccccg agatctggaa 19440
ggtggggggc tgctggtcgg ctggtgtcca gcccggttcc cagcagcttt gcctggctcc 19500
ccctggaggc tgcgggggct ggtgaggctg gctgggcaca gtacaggagt gggcaacttt 19560
ccgggggcgc aggggcaagt gagttggggg cttctgccca agtcacctgc cagctcgcca 19620
gccgctgccc ggcacagctg aacccgctcc tcacgtggac tcaggccctc ctgagaaatt 19680
gcctcgactg gatgtaagag agggtgccct agaggcctag gagcccgggg aacccccact 19740
taccccaccc aggaatggca gctccttggt ctcagcagca gcctgggggc ctctcctctt 19800
gaaggcagct cagggagcct ggcctgaagg gtttctcttc ctcaaacctt ctttgcccaa 19860
aggggcttgc ttcagcctcc atggtagggt tgggtgagtc tggcatggcc tctctcatga 19920
ccccgatgct ggaatgggtg ggcaacaatg agggaaatca ggatgctgac aggggtcctg 19980
aggtcaccca agccctcccc tatccataag gacacgcacg tggggacccc agccctggct 20040
ctgtggaaac cccaagctga cctggaggag gggatcagcc gcttggagga ccctcctggg 20100
tgcttggggt ggggtctgat gcctctatct gccattagaa gccatcccat atctcctcat 20160
cttcctcctc atccccagtg cctgtgcctt ccccttcctg gagtggagac caggggtcgt 20220
ctgcctggcc tggtgggacc cccttcctgt gtactgcagt gactcacagg agccgtgtga 20280
ggtgggagga cgtgcttatc tgaatgcagg agggagtgca ggcggggtct ggaggccata 20340
gggggcccag gtctgaaagg gctgagccca gcaagacctg cctgccggct ctgggtgaga 20400
aagcccttag gtagagggga ggggacactg ggatggggtc ctgggctgtg gacggaaggg 20460
ctggtgtgcc cggacacggc agcacaggct ccactcgggc ccctgaggga ccatcgtggt 20520
ggccttggcc atgggggtgt ctcaggtctg ggtaaggtgg aagtgccgct tggtctctct 20580
ctgcaccagg ggaagagatt gaggggcagg gagacccaac catcagcaca gggcaggtgc 20640
aatgtggggg ctcagcacag actggcaccc ctcacgccct ccctatttct accctggggc 20700
aggctctgtg agggaagcgg gtgctgctgc caacccctgg caggctgtga gcgagcaggt 20760
gggcgggcag gactcgggct tcctgtttcc cccgggagta gagcctctgg cagtgagtca 20820
ccacagcctc catcgcccgt ggccttggac agagaagagc tcggcgggcc atgtgggcag 20880
aggaggctgt actgctgggc aggccgctcc cagcggggat gacccagccc atcggtaccg 20940
cccggtggag gaagtggaca gagttgggag ctcactcacc tcagggacct gatggtggac 21000
cctcaccact gcttaccaga tggtgtctcg ggtgctccca tggagcagca ttcagccaca 21060
gtccacctgc gcccaggctc tggagcccct tgagccatgc tgacagtctc actgcccctc 21120
tgcctgggag tccaggggca actgatggag gccctggccc tcccagccag agccagctct 21180
caagagtgtc ccggaagcct aagtgagcgt catggccctt ggaggacaca gacttgggct 21240
cttcttctgc agaggggtta acagccccca aagggcagct cgaggagcca gcgggacagg 21300
ggctgcctga gggcttgggt cctgacggtg tccccgagct gggtcccagg caccttgtgc 21360
agactctggt ctgtggcagt ggaggtgcgg cttccatcct gccctgcact gaggctcagg 21420
aagatgctgt gtatgtcggg ggatgcatgc tttggggaca cttggggctg tcacaccaca 21480
ggcccatctc tccaaagggg cagattccag acaaggagtc ccagtgggga ggggtggggc 21540
aggcagccac cccccgccat gctgcaccag gacccagccc accggggcca ctgaagccac 21600
cactggaggc aacgtcaggg tcgccaacac tcccaggcat taagcaggac atgagaggtg 21660
ccaggaaggc cctgcccact ggctggggct tccggcaggc aagaggaagc ttcgtccctg 21720
agcatggcca gggccactgc cttggctcct tgggccaccc caagctgagt gccccaagct 21780
ggtgccatgg ggcccaggca ccagggtcac ctgggaaggg agtggccgcc ttgccacaga 21840
aagcccggcc ccagtgcagg cctcccgggg tcagaacact gccccagagc ggcctgacca 21900
ggctgtttca ttagctcctc tgacaacaga gaacggaact tgacttggtt ctctggagtt 21960
gagcaacacc aaatattttt tcacacaaca agctgagaag tggaccacaa acagggcccg 22020
gcattgctgg gaacacgggg cagcgggcct gcgtggagga tggacccctg ccggccccac 22080
aggcagcaac tgtggatggg ccaggcaggg ccagcaggag caggaatggg tgcagaagga 22140
gggggcagcc cagacccctc cctggccctg ctggatgcac cccttccatt cacccgaccc 22200
taccccacag tgaatccagc tgccccgcag ggacagggta gctgggaaca gagagaggct 22260
tctctcacag ggtgaaggcc ccaccaggcc tccaagcaga aggggttgcg gtggggatgt 22320
ctctaggaac agccctgccc tccgagccct catctgtcat ccttaatagc tgaacaattt 22380
ctcagctggt cggggaagtg ccttgagacc tgggtgactc ggtgtgctga gggccttcta 22440
gaatcatccc tcctgcgaag agcctgggat tgcataagtg ccctcctcct gcccagccct 22500
cccagctcca tcatctcttc ctatcccctc cccaccccca tcatcctgcc cccacacacc 22560
agcctggccc ctgctgaaga agcagggggc ccaggcagcc ttcctccaga gggagctttg 22620
ctccgcctct cttggggctg ggggcggggg tcctgcctgt acccccaacc ccacctgctc 22680
tctgaaggcc actctgggac cctgagctga gaaggcccgg gagccagccc cagctccctg 22740
aagggcactg agcccagagt ttctgcgtga aggcgtgagt ggcctgggca ggacctaggg 22800
cacaggtcag ctctccttcg ggggtgctct ggggaagcta gggctgggct gcgcctgcac 22860
caccctgctc ctgccttagg gccccaggtc cccatgtgac agactcaggt gtagctggag 22920
ctttgaaaca gagggggaca gtcaggagga agggtgtggc caggcctgac ccaaaggtga 22980
gggtggggca cgagggacac acggccgagc ccaaggggca gtggtggttt aggggccgtg 23040
aaggttcgag gaggagtcgg ggaaccatgc agggtgaggg ctggggtggg agaggcctgg 23100
agctgagttt gggaagggtg gcccctggac tgggggaccc ccagaagggg ctgaagtggc 23160
ccccaacgct ctcggcctga gctgctgggc cagccccagc ctcgaagcca ctccgctcca 23220
gcaccgggtc ccctggcgtg cctcctgccc agagctgctg agctcaggga aacgccagcc 23280
tgctcagtcc ctgggggtgg tggggtaggg ggtggttata tttaacattc tgcccggggc 23340
catcctgctg tgtgcaggcg tactaatagg gcagggaggg gccaggtggg atcccagtcc 23400
tgcccctggc ccttctcgcc ctggggccct ttccagagca aacacccaca ggcttgggag 23460
gacacggcca gcctgagaaa tggccttggc caggccggtg gggcccaggc aggctggggt 23520
ctcctggccg ggggagggtg ccggccatgc gcataccagg agccaatccc agagcctcgg 23580
ggccgcctgt ctgtctttcc tggaccccct tggtgtgcca cctgcatgat tgagtcaagg 23640
tctggtttat tggagcagga aaggcccggg atggtgtcca aaagttctgg caggttccat 23700
gtgctttacg gtgtcctgag tgagtgaaat gcatgtcatg atttctccag tccctttcca 23760
gctcagggtc ggtttgcctg tgttgccccc actcgactgt ggacagggct ggaggccagg 23820
cctgctcgcc cttgtctcct gggcccccta ccaggaagca gggtcctgga aggtgggcct 23880
gagtcagggt gggggaaggt gacgcctctg ctgtggagac tgtggctccc gggtgggctg 23940
caccttcctc ctagccctgt ccctccctcc gacggtgggt tccaggggct tgcgttgcct 24000
ccagccctgg gtgaccaagg agtgggcagg atcaacagga gggccacaga ggctgtcggt 24060
gaccagggcc catcacatgt gaacggtgtc ttgtggggca tcacctggct gtgggggcat 24120
ggaggagggt ccgtgatacc cctgggccca gggctggctc agtcctcagc ctgtgcgtct 24180
ttatgactca agcggggggc ctctggctcc cccaaacaca cccccaggat atccagggag 24240
accctgagag ggcgaatccc gcgtcccctg gggctgcatc ccccgtccca cccctggggc 24300
cggcacagcg gggcacacgg cttcatcacc aagcccatgt cccagggact catgtgtgtg 24360
acacaaaatg aaattcctcc cgcattagtg taaaacagaa cacagatgcc cagtgggagg 24420
ggctggcatc ctccgcgtca ggaagccacc aaccgtttgg gcttcaggtt gtaattccca 24480
atgcgctccc tccactgttc cgtttccatc atccggcgcg tccagctgaa atggaatggg 24540
tgtaagtgtg tttatgcctc gtctcagtct tcccagctgc tatggaaaag caccacagac 24600
ccggcagcct cagcaacaga gatttatttc tcagttctgg aggctggaag cccaggatca 24660
aggcgccggc ggaccaggct cctggtgaga gcatctctca ggcttgcacg tggcgtcttc 24720
tcactgcgcc cacggggcag agaatgcagg ctctctgctc tcttcctgtg gggcactgct 24780
cccatcccga ggccccactc tcatgaactc gtccaagcct actcacctcc tgaaggccct 24840
gtctctaaat accatcccat cagcggtggg ggcttcaaca agggaatctg ggggtgcaat 24900
tcagcctgga gcaggcttgg agggaaagaa ggggacgctg caaaagatgt cgtgggaaat 24960
cctccggggg attaagttgc cccttcattt caaattcctt aaacttcaag ggcatctgcc 25020
aggtccctcg ggagagcctc ctgcatgcag ctttcctctc ctctccagcg ctcatcacaa 25080
cagcggccac tgtgtgagtg aaggctgagg ccacactgcc tgtgcctccc cagcagtcag 25140
tgacgggcgt ggctctccga ggcagtgaac ttgcagagtg caggaagctg ggggctgcag 25200
agctcgcctg cagggcagca ccccagaggc ctggcagggt gggtgagctg tcccgtgacc 25260
cgtcacccct ccaccaggtc ccaaaagcaa aagcgttggt ggggtgtcag gagttccagc 25320
tgtacctaga aattgtcctg catcctgttc caggagatat cgtccatctt ggggtcaaca 25380
tggaatgcca cctgcatgaa cagggccggc gccggcatcc actgccattg cccgaggctt 25440
ggctccacag ggtggcaggc agggaggaga ggctgctgct ccctggcagg aagttcttgt 25500
gcaccacgtg agcgtgtggc tcccgaaggg gcattttgtg cctgtgcgac cgacagctgt 25560
gcccacgcgt ctgctgcatg gccatgtcta cacggggcct gctgcctcca gagggaccct 25620
ggggcttggg gggcctcaga gccctgtcag taggaagggg gccctggctc tcctggtggg 25680
tgtccggagc atctagagct gtcccgggaa gtgccgtgtc ccagggacct tgttactgat 25740
gattctgcca gtctggcaag tccatcaaag gcatcaccgc cttcagtgcc aggccacccc 25800
tcggggcttg caggcctggt gtccggctgc ccccagccca gcacaggtac ctcatgtcct 25860
tgaacacccc ctcctccatc cagtctgagc gccatggctc agcgcagccc cgtcccagac 25920
cagtgtccgt tcccctgagg gtgctgtggg ctggggaggc ccaggtatcc ctgccacctt 25980
cactctgagc ccgtctcttc ctctccaggt tttcataaga ggccccggga agctccatgc 26040
cctcctccca gcactcctgc tttcccctct gaatttttat ccatcatggg cccctgaata 26100
agagctgact gtgggatcca ggctcagagg ctcgagaggc acagggggag ggcaccaagg 26160
gccttgcagt ccaggccagc ctcagggtca ggcctccagg ggcctcaact ttgtgtcctc 26220
cccatggggt gcttttcatc cccggaggcc aggctggggg tggctcaggg ggcaccatct 26280
gcacaggtgg gggcagccgt gggcgggtag agacagcggg ccccgcgtgc actcccatcc 26340
tgagccccct gagcctcaaa caagagtgaa ggcagtgccc agggaagcac aggccaacgg 26400
gggcaggcac agccttgtgg tggccagaga accaggtcct cacctgcagg atccaggcag 26460
gccagtggtc ggcgaggggc gtggccagtc tgcctgttcc ttcctccacg tatgcaggca 26520
ttcattcatt cagtcatgca acagaggtca agttgagtgt ctgctgtagg caccagattc 26580
agcaaataca aatacaggat gcctggttaa atatgactgt cagataaaca gtgaatcatt 26640
tcccagtgga agtgtatcct atccaatatc ggggacgtgc ttatacttaa gacaattatt 26700
ttccatctga cattgaaacc tcaccaggtg tgtcatgtat ttcattggga tccctagctc 26760
cggctgggtc ggctgggctg ccccgagagg cccaacatga aggccccggc cacccacctg 26820
gattggagct tcctccgccc aggcagagcc tgggctcctg caggcacaga tgggcccccc 26880
accactggct tcgaggatga ccctgaacct tccctctagc agacaacaga tctgacaggg 26940
tcttcccccc atgagagggg gtgcccctgg gctcccccat gtgatcctga gggtaatctt 27000
ggtggaagca gcgctggggc ctgtccctgc cccacccagg aggcaactgc gtgggggggc 27060
gtgtggtgga cacatgacaa acccagccca ggatcccttg gtggctcaat ggcccaaccg 27120
cctccctgca cagacaggaa aacggagtcc tcagaagggc ggggcctgtc gagggccaca 27180
cagctgccgg gggggacctc agaaggaggg gtctgtggag agtactccag gtcccctata 27240
gtgtttgaac agggccttcg aaagattcct gtcctcccag aaccccagaa tgtggcttat 27300
gtagaaacac ggtctttgca gatgtgatta gttgaggatc tcaaggtgag gccattctgg 27360
accgaggggc tcagatccag tgacttatac gaagagaagg aacaaaccca gagacacaga 27420
gaagaagcca cgccgggaca gacgcagaga tcagagtgac gctaccacga gcccagggcc 27480
accaggagct ggagacggcg gaggacccgc tacgcttgcg ggggagggtg gacctgccaa 27540
caccaggatt ttgcattctg gtctccagaa cagagagaag agaccgctgt agttttgggc 27600
actcagtttg tggtattgag ccccaggaca cccatgcaca aatgagaggg tgcaggggtc 27660
actctgggac agcaccaaag ccgggggggc cccaggggcc actaaggagg ttcccacgtg 27720
gagctgtggc tgcccttgct gggtttggga ccctcagccg ggtccaggcg gacagagtct 27780
gtttccagca cagccccgtc cttttgctgg gcggtttgcc tgggcgtgtc ctaagttgat 27840
tgaatatatg ctggaaagca gaaatgccgg aaaagaggcc ccctcccacc cgccctggga 27900
gcccaggtct ggcaggagga accacctggg cgataggggt ctggggagga agaggggttg 27960
gtgggcagca gcctccccgg ccaccaccca ggagccatgg ctgtgggggc tcggagtggc 28020
caccccaccc aggaggaggg gcctgtcagg gcaagagacc cccacatcct cccctgacct 28080
tgatccacag aagggccggc aaaggactgg ggagaggcct gcagtcgtgg gggcaggggg 28140
atgaggggag gggacaggag gagccagggc gctgtctggg ctgggggctg ggctggggca 28200
ggggcagctg agggcctgcg gtggatgctc ccagcccctc tccacagcac tacgtggcac 28260
agggccagca gcccccgggg gagactcccg gcctgcaggg ccctctgggg cctccctggg 28320
tctcggatcc cttccaggga cctggatgag gccgtacccc cagggacaga agtgcccctg 28380
ggagcaaagc cagcccagtc ttgggtggcc tgagctcaga gctccccctg gcttctgtgg 28440
ctcgccatgt ggccagggcc gcatctttac ccccaccccg ttccaagcct cagtgggtcc 28500
cttggtaggt agaacctgtt gggagggtaa agcgaggcac cccaggtaag ccaagttctg 28560
ctacggacgg ggccccttgg agacccagat cagactctgc caaggcctcg ccctactccc 28620
gcccccaacc tgatgattag ctaattaatt ctgtctctcc ctccctctat ctctccttcc 28680
ctctctctct ctctacctct ctccctccct ctctctctct cactctctac ctttccctcc 28740
ctctctccct ccctctctcc ctctctctct cttcctctct ctccgtcttt cctattctct 28800
ctctctctcc ctctctttcc cattctctca ctctctccct gtctctctcc ctccctctcc 28860
ctctctcttt cccattctct ctctccctct ctccctcttt cccattctct ctctctccct 28920
ctctctctct ccctccctct ccctctcttt cccattctcc ctctccctct ctttcccatt 28980
ctctctctcc ctctctccct ctctctttcc cattctccct ctccctctct ttcccattct 29040
ctctctctct ccctctctcc ctctgtttcc cattctctct ctccctctct ctccctcttt 29100
ccccttctct cccctctccc tccctccctc tctccctccc tcttcctctc tccccccctc 29160
cctcccccct ttctccctct ctctctcttt cccattctct ctctccctct ccctctctct 29220
ctctctttcc cattctctct ccccctctct ctctccctct ttctccctct ctttcccatt 29280
ctctctctct ccctgtccct ctctttccca ttctctctct ccccctctct ccctccctct 29340
ttctccctct ttcccattct ctctctctct ccctctccct ctctctccct ctctctccca 29400
ctctctccct ctcttttccc ttctctcccc cctctccctc tctctctctc tctctttctc 29460
tctctccctc tctctctgtc agtttcccca ctctctgcag ggtcccctcc acagtgatta 29520
gtcaaggccc agcccgaggg gcctgggaac ggggaggggg agcccagccg tgtgtcacct 29580
ttgggagagg aggacctctt ccatgcctgg tggtactgtt gtgcctttga agggaggtgt 29640
ggcaccaggc cgggtggtgt ccgccatgcc aaaggccact ctgcatcccg gcccccagcc 29700
cctgggtact gctcctccag cccccactcg ctggcctgga ttctccggac agaggtgggg 29760
cccacagggg agcaaaggac catccagaga gcgtgggtct gtgccagggc ccttctcaga 29820
gcagccgaag gatgaccatc ctgactgacc gtcccaatct gcagcctggg actgggacct 29880
gctgtgcagg gctctaaaaa ggcgagtgag ggaaagatgt tgcagtgggg aggccatcct 29940
ggcccaaaac gcagtcacaa agtccttaaa agagggcggc aaagagggtt aaaatggcaa 30000
tatttgtgtt atgcacattt actacaaaaa caagcttgcc ttaagaaaac tcaaaaaaga 30060
aaaagattaa caggcagaag gagatggccg tgtgaaggcg ggggcagaga ctggagtgat 30120
gtggccaccg ccgaggggtg cctggagtcc ccagaagttg gaagaggcag gaaggaccct 30180
ccctagggcc tccaaggaag cgtagccttg tgacactgga cttcagccca gggacactga 30240
tgtccaactc tggcctccag aactgttgct tcaagccccc cgctgtggta ctttgttatg 30300
gcagccccag gacaccccga caccaggaaa tcgcataatt gtttggaggg agaacatcgg 30360
ggcagattca cctggtttct atgtggggca gaaaagagcc agcggccaag ccacccgcag 30420
gcccctcctt gggaagtgag acccccacag cctcactgcg gatgtaacag ccacccacgg 30480
cctgcctggg aaaagcccag atttcaggag gccctgatta ggtctcccaa gactcacgcc 30540
ctgttccggg ggaacaggaa gtgggaggca tctccccaga actcagggag gccaaggcca 30600
tgcccacgga ggggcagaga gccgggggcc ggagagtgag ggccgcagcc acgggctggg 30660
aaggggagag ggccgggcag gggtcctggg agaggggcag cccaagccca gcttggagag 30720
acatctcccc agcggccccg gcatgtgctc agcagctggt gagctcaatc caggagtgtt 30780
ttgccgggtc tggttatggt gattcacaaa ccccttttta atctggaaca gctcccacca 30840
ggcgggtccc ccaggatttc ccaccctacc cccgggattg tgaatctgag acatcacacc 30900
acgattgtca cgtgacatgg tgttcgggat tgaactgtgt cccccaagat ttatatatca 30960
aagccccaac ccatggtacc ttagactatg actgtatttg gaaattggtt ctttagaggt 31020
aattaaggtg aaatgaggtc attcagttgg gccctaattc aataggacta aggcccctct 31080
ttatacaaag gaggaatggg gagacaggta tacacgggag atataattaa gttcgctgag 31140
cagttgaatt tgaattaatc aaagggcgat tatccgagtg ggctgcgtct actcacacgt 31200
gccctctgaa agcagcgttt cctctggctg gcagtggaag aggtgaagtg actggaggca 31260
gcagggaact gaacacatct gtacttgctt tagagatgag ggcatatgcc aaggaaggag 31320
gtggccctgg ggagctgaga gcaaccccct gccagcggcc agcaagaaag ggggtcctct 31380
gtcccactgt gcaggagggg attccgcaga tggcgggaat gagcctggga gcagattcct 31440
gctgggctcc agatgcgggc ccagccctgc ggatgcctcc gtctcagcct catgggaccc 31500
tctgcagaaa accaagctca gctgtgcgca gacttctacc ctacagaact gagaagtgat 31560
aagtgggtgc tgctgtgagc ttccaggctg gtggtggttc gttacgcaac agaggtagca 31620
cgtacaccag gcctctcgtc ctgcagaagt ttccaccgtc tgcacgtgtc cggtggcctc 31680
tctgtgggtg gttcagcttg ttcttctgcc tccagtattt tttgcaaagt ggaagttggg 31740
tctgcaggcc tgctggacag agcttacttg atcgaggctt gaaaatgttg cacgtgccct 31800
tggtgtctgc gtgtggcctc aggtcctggt tgcccgtgtc aaagatggcc tgatggacct 31860
gctggggcca gcccaacccc accactgggc aggtacttcc ccctggtcac ctcaaggtgg 31920
cctgtggctt tacgagcacc cagtgttccc tctgtggctc ttggccccct ctgaaggccc 31980
ttcccaagcc tgtccttcca ctgggacctg ggaggtgcag gctgcctttt tctcttcctc 32040
cctccatcag cgttacccac attctcctct gcactgtgct gatccttcat ccatgggagc 32100
tgtgcacccc caaatataat tcctgctgga aacaccctcg accctttctc tttaatgaca 32160
gattttcaca gtaaggcagt gttgaattgc agcctctagt ggcgacaaca aggaaagggg 32220
ttccctggac tcccccttcg gagcatcagg tgtggaccca tggagttccg tggacctgcc 32280
gtgtgtggtg ggccaaataa tgctcccctg aagatgtcca tgtcctgatc ccagaaaccc 32340
atgactatgt aaccatgcgt ggcgaggggg accacacgtg gtgaggggga ttagcagata 32400
tgattaagtg gagggccttg aagatgggaa attatcgtgg atgatctggg tgagccaaga 32460
tcatcacaga ttcctagggg agggaggcag aggttcagag tcgctggaga aggagatgag 32520
caggggaagc aaggactgga gcgatgggag gaggggccca gccggggagg gtggtggtca 32580
ccggaagctg gaagaggcaa ggaaatggac ccctccctgg gactccagaa ggagccagcc 32640
ctgccggcac ttcaggcttg ggatttcgga cctccgggat ggtgtgctta aaacacttgt 32700
gttggccggg tacggtggct cacacctgaa atctcagcac tttgggaggc caaggcaggc 32760
agatctctcg agctcaggag ttccagacca gcctgggcaa catggcaaaa ccctgtctct 32820
acaaaaaata caaaacttag ccgagcatgg tggtgcatgc ctgtagtccc agctacttgg 32880
gaagctgagg caggaggatc acttgagccc aggaggtcca ggctgcagtg agcgatgttc 32940
atgccactgc actccagcct gggcaacaaa gtgagatccc gtctcaaggt aaaaaaaaaa 33000
aaaaaaaaaa aaagtgtggt ttagcaattg aatttgtggt catttgtaac cacagcagca 33060
ggaagcccac acgccatgtt tgaatcattg tcccctctga gatcccaccg cctccacttt 33120
ggccaatggg agcccttccc actggcttcc gtacccttgg acatgacccc attcctcttt 33180
gcaacttcct tgttctctag caaaactaga ttttccacac tctcgaacct tccctgccct 33240
gagtcagtca ttctctgggg atgggtcttt cagcgcggct cgcgttagaa tctcagtcgc 33300
ctggcgtgtc ttcattttgg atcacagtgt cctgcatacc cacaatgtta ctaattttat 33360
cattgttttt actccaccaa ggtttaaatg cttacctgtt ctataaccat attttgtgta 33420
attctctaac gctctgtagc cacctcagtg ggcttcccgc tgcccaccca ccctttcata 33480
cggcttcttc acgctggaat tctttctttg gcatttcttt tagcagcttc atttcatctt 33540
tgaggtggct gtggttgttt ttctcccaac aagggcgtgt gcatttgtgc cgcgttctct 33600
cacgttcctt tgcgttggag gacatcgccc ctgtgtctct agactcgagt gacattttgg 33660
ctgggtataa tagtcctaga cctcattttt tcccattaga acttgatcag catgggaccg 33720
tcatcctctg gtgcttagtt cactgcagaa aatctgcagc cagctcactt cacccccttc 33780
gtagtgactc actggttctg tcttgtgcac ctgcagaatc ttctttaccc tcagctgagg 33840
aggtggagta ggagccatat ctggatggaa tgcatcctgt gtcttgtttt cctgggactc 33900
cgtgcacagt tctttctttg cttcatcatc acatatctaa atacttttca aatatgcgtg 33960
tatatatata tatatatata tatatatata tagagagaga gagagagaga gagagagaga 34020
gagagagaga gagagagaga gggagtctca ctctgtcatc caggctggag tgcagtggca 34080
tgatatttca gctcactgca acctccgcct cccaggttcg agattctcct gcctcagcct 34140
ccccagtagc tgggattaca ggtgcccacc accacgtcca gctaattttt gtatttttag 34200
tagagatggg gtttcacctt gttggttagg ctggtgttga actcctgacc tcaggtgatc 34260
tgcccgcctc agcctcccaa agtgctggga ttacaggcat gagccaccgc aactggcttc 34320
aaatatattt taaataccaa aaactagttg aggcttctac ccaggggtac aagcaatcct 34380
ccagtggaag tgtcctcacc cttcctccgg tgcctggatc ttgttgtgcc tttgctgtgc 34440
tggtcagagc cagccatctg tgtctataat ccaatttcag ccatgcctct cctgttcctc 34500
ctggcttggg ctcattgagt cataactgta tggcgtgtgg gctctccgct tgcttctgga 34560
gttctgtggt ctccccctct gccactggct gctgagatga acaggctcat ctcatcttcg 34620
agtgtggctt ccattgcacc ttgtccttat caagttgaca cagtgcccaa attcctcctg 34680
gggaacttcc ttcttctctg ggttttgttt tattgttggc cgggttcttt gtctgctgaa 34740
gtccaaccta tctctctctc tctctctctc tctctcattc tctctctctt ctcttttttc 34800
tcccttcctt cctttccttc ttccttccct ccttcctggg gctccatgcc cttctcccac 34860
tgggggcaat caagaggtct cacctcagtc caagggtcag ccctggtgtc tccccagcca 34920
gacagtgacc aaagtcagga cacaccccct ggttgcctcc tgatgagggc taagggtgag 34980
gattccggca ctcccagttt ggactcagaa gacaggagca gtgtggggag cagcaccgcc 35040
tgtacctcct ctgtgactcc cctggacacc ctccaggagg tctgtgatgc tgacctgccc 35100
tctccttgtc ggctctgagt cattcatctc cagttcttac tatgcttgtt tgttgtcctg 35160
ggttagtgca gccctcatac ctgcccccgc acctgccccc acacctgcct tcacacctgc 35220
ccccacaact gccccccata cctgcccctg cacctgcccc acaactgccc tcacacctgc 35280
cccccacacc tgcccctgca cctcccccca cacctgccag cacacctgcc cccacacctg 35340
ccctcacacc tgcccccaca cctgccttca tacctgcccc cacaactgcc ccccatacct 35400
gcccctgcac ctgccccaac tgccctcaca cctgccccca cacccgcccc cacacccgcc 35460
cccacacctg cccccacacc cgccctcaca cccgccccca cacctgcctc acacctgccc 35520
ccacaactgc cccccatacc tgcccctgca cctgccccca cacctgccct cacacctgcc 35580
cccacacctg cctttgcacc tgcccccaca cctgccctca catctgtaaa tgtcacactg 35640
cccagccctg cactcctctc ccacttggcc agtttcaggc tgtaccactc caccgaggtg 35700
accccagcta gtttggggct tcagatccca ctgctgagcc ggagacccag atgggtctca 35760
gactgacagt ctcagactgg cagcccccca tagcaccagg cgtgggtgcc cacccacgag 35820
atgtcacctg gcaggcactt tgagaatgtc cagaatgggt gtcataatcc accccccgcc 35880
tgctcctttt gtcttcccca ccttggggtg tcaccacctg cctgttccct ccccccagcc 35940
tgggcgctgt ccctcccccc tagtccttca ggaagtctag ccagtgccac cttcaaaaca 36000
caccttggat ccacctggtc ccctgtcctc tgtccagccc gcagtcccac tcagctcgcg 36060
gtaggcaaag cgaggcccca ccctctctgc agggctcttg gagacacgtt tgaaccacag 36120
cgtctgtgtg ctctctaaaa gggcagttgt tattttttcc tgagtttcca ggatgtctgc 36180
ccctgtgtag ccatagggtc gagcctctcc aggctccatg ggagcagaaa gtgctgggga 36240
cacctcaagg ctcacgtggc tctgtggacc ccgagcctgg ggccccagcc caccttcccc 36300
tccgtgcctg gctccagcca tgggccctgc acccgtcctg gtgccctgag gccaggaaag 36360
ggggcttctg ggactgctgc tcgatgccga aggtattgtc cttcccacat gggaatcatc 36420
tcactggact ttctgtgaca aacatagaca gtcatttcaa aataaatcaa acttcagacg 36480
tggtacagca gcaagttgcg aagatcctcc tcccctcccc gcaccccagg cggcacctgc 36540
tgcagccggc tgtgggcact ccatggacaa cacggcacag atgttctctt gtcacataac 36600
tctcatcctg tacttcaaag gccacgagta agtgaagacc cactgcactc tcgaaaagca 36660
ggaacggaaa aagtcacagc actgcatcat ggagcagccg ccccgggtgg gcgcgcgcgt 36720
ttgcctcctg cgtgaggctt cctccagcac tgcggtgggc tgtgggttcg ttcccaggga 36780
atgtgagcga gccgcatccg cagcccaggc accctccctc ccagcttcct ccccgcccca 36840
gggtgaccat gtatgggcag ccctgatgtc catcggccct ttgtgcagtc atggcgcggt 36900
gaagggccct gcaggcggcg cccaggggtg gtgcggggct ccgcctggtc tgtttactca 36960
cagcacagca tggggctcac tcagcagcac gcccaggaga agagcccagc ctcattcttt 37020
acagccgttc tggggcactc cacaggaggg ttgaaggggg cttccatctg ctggtgctcc 37080
ccaacaccag gggctggcag agggtactcg tgctttgcag gtacaaacag cgctctcccc 37140
tggggtagac ccgagccacg acaggcagcc agggcgacat gcataggagc gtgtgctcag 37200
accacacaca gtggcttttc aggggatttt ccttactcag ccacatcggg gagggcgcta 37260
gggcaggtat cgggagcgcc agtgagttgg tcattttctg agcatgatgg cggctcagcg 37320
tttggacccc cagagggagc agggccctgt gcctcagcct ccctcgagtg gtccagccct 37380
ccctcagcat gggtgctgaa gaaatggaag cctgtgctgc ctgtcaggga cctgccgctg 37440
gagttttacc cccaccccat ccgcgttggc cacccaggcc cctgtggcac gggtgcatgg 37500
aggcctagtg aggtcagaaa ccgtccagcc aagggtgggg ggattcaggg tgggggaaca 37560
ggcagccggc tccgggaggg cttctggtgt gagtttgggg cgggccggcc cactccctgg 37620
agttggtgct gtcagggggt cctaggccca cctgcctccc acaggcctct gtactcactg 37680
ggccctggct gttggttggg ggaagaaata gagacagatc cctggcttgc aaggactcca 37740
ggtctggggt cagagcgtgg acaagtccgg agggctctgc cacccggcac tgctgaggac 37800
aggggcgcat ctgacagcct cctgcctcta ccgagctggc ttcggggcag ctgggcctcc 37860
cggtgccaat accccccggc tgttacctgc ctgtcacctg ggcgagtcac ctggagccgc 37920
gtctgtgaca tggaagggaa cggttacaaa agccacatca tgtgagatgt gcgggcccag 37980
ccaggcatct ggggcagacc agcgctgcac acacacaggt gggatctgtg cccggtgccc 38040
agcctggcat acaggcacca tcccggagtg cccccatggg ctgtgccctg acagctttgg 38100
aggtaggaat tggggggtga ggaccctggt gaggacaggc aaactcagcc atcacccccc 38160
tggccagggt actacaccca ccccacacca gggctggggg ctaggggtgg gcacagcttg 38220
ggcaggccat cctgagcgcc aggcctggtc cgcaggccgg ctggagggcc ctgccctgcc 38280
aagcgggact ccggctcctc tccagcatct gccgcccggg gtgggcgccc agggccacca 38340
gccctcgcgg ctcctcccct ccccccgtgc gcgactgtca ttgttaccat tgcttggctt 38400
ctgccaaagc agccgcaggg ccaccgggtg cttgaacctt ctccatgggg cgtcctggcg 38460
gtggtttgag ccgggcagtc ctccccgccc tccccagccc cccagccccg gcacccggcc 38520
gttccactgc gcggcggcgt ggggagggcg cggcgcgagc tgagatggtt ccgcccggcg 38580
ccgcccccgc tgcccgccgc ccgccgcccg ccgcgccgag cgctcccgca ggatggcgcg 38640
ggccaagctg ccgcgctcgc cgtccgaggg caaggcgggc ccggggggcg ccccagccgg 38700
cgccgcagcc cccgaggagc ctcacgggct cagcccgctg ctgccggccc gcggcggggg 38760
ctccgtgggc agcgacgtgg gccagaggta ggggcgcgcg ggcctgggac cccgcttgtc 38820
aaatcgcgct tgcatcctgc tcgggctgcg ctggctgggc tgcacctgcg ttgcctgcag 38880
cccggggaag gggggaggcc agggtctccc ctcctaagcc caccacagcg ccctgcttcc 38940
tgccgtgtct ccagcctttg agagcctgcg ggacccccca ctccccccac gtaggggctg 39000
aacacggcgg ggctgcaggt gagactgcag gggagggagg aagtggaccc agctctgtgc 39060
caggcactgg gggcccctgc ccgagccctg tcccacagga gccccgatct tgttggtgcc 39120
agcgccactt tgggggagac agggccggca tccgtgtccc caccccagag gtgagtgagg 39180
ccgaagcctg cacagcaggt cagggctggg acacagggct caggctgcct ggggagccct 39240
gctgtggggt atgcttgggc tggtgtctgg tgcttgtggc aggaggggtg caggtggccg 39300
tcctctgggg atggttgggc aggtggagca gcgcctaccc ctccttggct cttccgcaag 39360
ctcagggtgg gacacagcac ccccatttca cggatgagga caccaaggcc tcatctgcag 39420
cagcaaattc ctagccagca cctttcccgt gccaggagcc gttctagatg ctgcggggga 39480
aatgaggatg aatcagacct ggcctggtgt gggcacatgt cgtgggcacg gaacctgttc 39540
ctgggagaga gaggtgcagg ccaggccggg acagaagagc cggggactcc tggggtgctg 39600
gtccttccgg gacaagcatg gggagatggg caggggcctt ccaggtagcg gaagcagtga 39660
gggctgaagt ttcatcaggg ctggggggca gggctggcag agcagggcct ggcagatggc 39720
agggccaagg gtgcccagga gcctctccct tacccctcct acctggctgt gggctgttgg 39780
gcccctcccg gcacccccat ttctagctct tcacagcagc cctggggggg cactgcccag 39840
cttagtccca tttgcagaag aggcggttga ggctaaggtc aagcacctgg ctgcagcctc 39900
ctgcagctaa tgggcagcct ccgccaggga ggcgagcact ggccaaggcc ctggggacca 39960
cagtcccctc cccctcctct tcctggatgc tggcgtgggg ggaaggggga gggcagtgat 40020
cctggaagcc ctgctacagc cagccctcaa ggggcaggtt ccttgcccca tccctgttcc 40080
tgcagggccc atagggatag caggttctgc ccaggctgcg tctgagcccg cagtgcagtg 40140
cagcatggga gctgtagcct aggcccacct cctccaggaa gccctcccgc atgttcatcc 40200
cagccctgtg ggctatgcac tgtgctgacg gtttcacatg ggtggcctcg ctcatccccc 40260
ggcagcccct gaggtgcaga gtccttatag cctccttttg cagagcagag gtaatggagc 40320
tgctgcccag ctgggctgag cagcccctgg gcctggagca ttcatacaac agggctcgcg 40380
ctgagatgag tagggcaggc tcctgagcag aggacttggt aggtttgttc ttctggagtg 40440
tggatctcac ggaaaacaca ggcgaggcca gagccgagag gcaggtgtgg tctgccccag 40500
ggagctgggg gtcgcagtgc ccgcagctgc ctcatcctgc aggcctgagc tgccttcatg 40560
ggccagccag ggtcccggct ccctcagccc tctcagactc tgcccgtctc attgttgaga 40620
agacagtgaa gcagaggaga ggtctccact gcccaccagg gactgagcca caggaggcgt 40680
tgtcggggga gggcacttgc tcctggtgcc cctgcccaga gctcccctaa caccctgtgc 40740
ccacttatgg gtgctgcagg ctggcctctg tccctcctcc cacacagtcc agctcccctg 40800
accctgagct ccggggtctc ctccttcctt ctcactcccc tgtgtgaggc tggggaggga 40860
ttgggagctg attagacagc gtggcttcag tggtggggtc aggagaccat cactgcaaag 40920
cttttgagta aaagtgccca atggggggac agggcctctc agtgagaccc cgctgcatca 40980
ggaggccctg agcccctctg tgtccctacc acccctggac ctaggcggcc ttgcccctcc 41040
cagctggggt ctcccagcct catgcctgac ttaaggcacc aacacagccc cctccccaca 41100
tcctctccgg ggccgttccc ccagccccat cctactcttc tggccctagc actgcactgg 41160
gcagggggcc catgctgagg agctcacctg gactgcgtgt tctgccccca caccatccct 41220
gagggaggtg gggcacctct ctttgacccc agggagcaag cctgaggccc ccacacagcc 41280
tgaggtctag cgtggtccag ttctcctgcc actgtgccca gcaccccagt gtctatggca 41340
gccacaggtc tgtcagtcca gctgtggcac gcagagcccc ggccccgccc caagcccctc 41400
gccctgatgt tccttggctc aggagatggt cccctgagcc ccccgacccc ggacaccctt 41460
gccaggacct ccctcccctg cagatccaga ccttcatggt tgcccctctc ctctccaaga 41520
acctggctgc tcctccatgc ccccctcacc ccgggcacac gcccggcgcc ccaccctctt 41580
catggtgttc acaccggctc ggcacacccc ttcccctggg cctgaagccc cccttggagc 41640
ttgccccaga tggcctctct cccaggaggg cccctcctga gtatggtccc gtcacccctg 41700
aggtgccccc gccctcctct ggctttgccc cgctccgggc tgcacacctt ctttccacac 41760
agtgctctgc gctctttctc ccccacccta gaatgcacct gtttgggcgg ctggtttatc 41820
cttgacccag gagcgtgcac agggagtgcc cagccgcagg ggtggggctg tgttcccagg 41880
ccctcggggg acaccaggcc ctgtctttca ggggtgtttg ctgggcccac acctcattta 41940
ttgtctcaca gtcctggagg ctggaagtct gagctcaaga tgtgggcagg gctggttcct 42000
cctgaggccc ctccccttgg ctcgtagaca ccatcttctc cctgtgtcct ctcctggccg 42060
tcccgctatg tgtgtctgtg tcctcatctc ttcttataag gacaccagtt ttgtgggatt 42120
agggcccacc ctcatggcct cactttacct taatgaccgc tttaaaggcc tcgtctccaa 42180
acatagccac gtgctgagat actgggggtc aggacttcag catgttagcc tgggggcaca 42240
aaactccgcc cgagataagg gggtgccttt gttgcgtgtg ggaacctgcc gggacctggc 42300
tgtgctctgg gcattcccca ggtttagaac agaggctccc aaactccccc aagcagggaa 42360
ccccctcttc cccaaagcat cttatgggac ttggggttgt ggggtgcaga gggacactcc 42420
actcttcccc cagtcagccc agaggggctc ctagagagcc cagagggtcc ctccctctcg 42480
aggctggcag ctgagactgc tccttatggg cacaagtcaa gtggggatgg cccctcctca 42540
cctgggctcc ttcccgaccc cagccccagg ctctgcagga cacagcaggg aagcagggct 42600
aagcccagat ccttccactg accactgctg ccctaagcag ggctgagacc ctctcctggg 42660
agggaggtga cggcttcggg tgcaggttct gttcgtgtgt tgacagcgag cctggccatg 42720
ggaggtgggt gggcccaggg atgaggccct caccacttgg tcccaacagc taagttaggg 42780
ctggcagaga tgctgagtgg cacccaggcc accaaccgct gggacaggcg agcatcaggg 42840
tcctcctgga ccaccgtggg tttggatgct gcggatagag gccgagcttc ctcagctccc 42900
ctcccctccc ctcccacccc tcaccctgca gttcacttgg cagggtttgt gcagccgaca 42960
gaccttgttt gcacagagct ccagtcctca gccaggttct gcacaggcca gcaaagcccc 43020
aggtcccttt gcccacaggc cgctgccctc cccttgggag tccctgggtg gatcctctac 43080
ccatgtgctt ggtggcccct tccaaaatca gtggggacgg ctgtcctggg cctcaggctg 43140
tgggacatct gacaggtggt ggcttcctca acactcagac aacagggcct tgggcagagt 43200
agatgggagg ccccatgcgc agctcagtag acactcagct agggctatat cgggagatgc 43260
agagggacgc ggccagggag cacctgggag agaggacaca gtgggcccca gcagggagga 43320
gcccagccag ggcctggcca cgccggacct gacccacagg ccaggcagac ccgctgccat 43380
gggctgaggc actgccaggc tcctgccagc ctctgacacg gctgttgccc tggctcagag 43440
cttcaggcag caccagggtc cagcgagagg gaagctgagc cggacaaaca cgcagaatct 43500
gccagaagct cccagcaaac ccaaagatca gccccattaa gcctggggtt ctgcctgctc 43560
cgtgtggagc tgctggcccg gccaccatgc ccagccagga cctcggccct cccaggggtg 43620
tgtccagctt ctgcctcccc cagggaccag aagctgctag ggctaggggc accaggaggg 43680
cacctgccca cccggagagc ctggcgtagg ccgatgagcg tgtgcctgtg accccaggct 43740
ggcttcctcc ttcctgcctg tgtggcctca gaagactgtg gtcctctctg aacctttgtt 43800
ttcttttctg aaaacatggt tgttttgagg attaaaagag agaggtccct ctgaagtcct 43860
ttgaggagga gctggtccag gacaggcaca tagtcagtga aggcaaagac cctcggcact 43920
cccaccctgc ccagcccccg accaggccgg ccctctggag ccctcagctc ccatcagcct 43980
ctctctccga gttccgaatc cagtgcaggt tgcaaccacc ttggtgtcag ccgcctgctg 44040
gccagtctgg gacaactggg gccaggttgc ctggggccag gctgaagggg tagcaggtgt 44100
gtggctgctg gcgtggtgga gggtggtgtg tccaggtccc ctgagaggca tcagctctga 44160
gccctggctt gtcctatcgc agggagcctt ggggcagggc tggcgggtgc ctcacccgct 44220
ggtctgggtg tagggcaggg gagtggagac aaggggacag cctcgcagac ctcggcatga 44280
ggtggagctc accgcgctcg cttctggatg ctggggacca cacatggggc ctgggctggc 44340
ttcgtgctga gcagggccag ggcgagtgcc caaagcatcg tcacctgctt gcgtggctga 44400
agggtggccc tctcctcgag tgtggttgtc acccccccat ctggcccagg cacaggaggg 44460
tgcatgcgcg gggacctcca agcgggctgt gctgctttct cgggccctga gggggccagg 44520
cttggctcag tgcccccaca tggctctgca catggactgc ctcccacagg cacctctccc 44580
gtgcccgggg gcgccaaagg tccgggcccc ccagagcctc cctgcgtgtc tgtgccccgc 44640
ctggtcccag agcccaggct ctccatctgt ctgtctactg ccttctccat ccgtccgtct 44700
atctgtctgc tgccttctcc atctgtccat ctgtctcccg cattctggtt gatgcccctc 44760
tgtgtcccca ggcttcctgt agaagatttc agcctggact cctccctgtc tcagtaagtg 44820
ctttgcaagg gaggaactgt cttggtggca gacaagggct cttagaggtg tgagagccct 44880
tgtttctggg gggtcccctc aacccagcat cccctgcagc tgggccaggg ccaccggcac 44940
ctcccagtac ccgctggtgc ctctgggtcc caggtgctgg ggctggagac aggacagtca 45000
gtgtgccccc ttggagagga gcctgaactt gggaaatggg ctccccagag gtgggtggtc 45060
cgcagcctca ggagaggcgg atggcagagc aggggccctt gtcatggtgc ctcccaggga 45120
caggcaggca ggcagctgct ggggcctggg ctctggctca gcccaccttg gctgcctgtg 45180
ccggtcgagc tcccaggagc tgggatgcgc tctcggaggc tgtgccactc cccactgagc 45240
cgccggggct ctgccggtgg tgcttcctga cttcagctaa gatgtaggtc aaatggaaga 45300
ggctttgagg ccagggcagc caggccctgc gcactcctgg gaagcccccc gctgccatcc 45360
accttcagcg cggtctccag gaggggcccc aggcttactg ttccatgcac ggcaccagca 45420
gcagaaacca ccgagcactc agcactcacg gctgttgagc atccaggggc tgcccggcac 45480
ccatggtggg acctattatt atcccaaaag agtcctggag gctgggaggc cagtggccac 45540
caccggacct ctatcttccc agcctggggc cccatggtgc agagggtgac gggtgtgaga 45600
tagaagccgt gcccaccacc cagggttctc ctggccccac cccaggctcc cgaggagtcg 45660
ggtctcagac ctgtggagga aatggatgcg tctgcagccg aggctatagt gtgtgccgcc 45720
gtggcacggt ctggacacag ccgatgttcc tggacctttg gaggcccagc tggactcacc 45780
cttcagccct gagccagcct cacctgggcc cctggccaag ctatgggggg gccccagagg 45840
cccaagggtg tcaaaacagg gaccccaggg ggacggagac atgtgtgtgc cctttctggg 45900
cccttgggcg tatcagatgc tctgtccagg ctcagaatag ctggccccag ggttggcagt 45960
gggcctgaag cctgcccttt cttcctgcct gcctgcctgg tgctgggggc agaggcctgc 46020
gtggagctcc caggcacctg cctaagagcc agccggcacc cagccactgc cagagagagg 46080
cagctcggac ctcggcccca tgtgagtgca gggctatggt gggccccgag gcgtgtgcct 46140
gacagcctgg agctggtgtg gagcttcccg gcatggccat ctgtgtatga ctacctgcca 46200
ggaatccctg gaaggccagt cccccagcct gcagctggcc tgccggtcag cagggagaac 46260
tgttgccggc ctctgccgac cccatttgtc acagggcggc cggcacttgc ctcagagggt 46320
cccgtcttgg tgtgggggtg ggcaccatga gagccccttt gcagcacaag ggcctcctca 46380
ggcagagcag tggcgtgagc ccctgggcac aggcaggcag tgggcatggg tacacgcggg 46440
gcccaggcct ggctcaacac cagccttgca ggactggggc agagccgcca cctggggaca 46500
gactcccctg ctgccgctac agggagcccc aaggacccag gcctggcact gcctctgacc 46560
tgctgagtga ctggggcaag cgtgggcctc ggggagcctc ggggggctac agcgggcttc 46620
agccgtgtag ggacggggct ggccaggagc tgcctgtcct cacggtgcca gggacaagtt 46680
gttcgccatg ggccagcgcc gctgacggct ctcccagggc cagggccagg gccagggttt 46740
ggcctgtgga ttcctcaggg accaaggcct caccccaggg ggtacacaag ggactgtctg 46800
aggctccctg ctgtgtctgg gaccccctgg ccaggcctgc ccgcacatgc ccatgagtct 46860
caccggccct gcgtcttgct cctgggctgt aggccgtggg cagtggcggt ccctggtgtg 46920
ccccgtcctc cccaccagcc gaaatgcaga ctggcagagg tgagacgggc ccggccccct 46980
gtggcgagtg tgtggctgcg ccctgagccc gcctcccagg gtgggggtcg ggacccgtgg 47040
ccggggatcc gggaatgcag cacccgctgc cgggtgtgga ctctgggaat ggcgatgttc 47100
ccagacggat gccgccatga gcgctcactt gctgtttgcc agataaacaa atgagtgaac 47160
tgatgagtgg atgagaatgg acacaggaag tagattcttc tgccccgtcc ttgcctattg 47220
tcctgggagc ctgcgttcac aggcaggttc ttcctagccc tgtgggcggc tccccacggg 47280
agttctcggt catctcccac ctctcagggc gttccaccga gcccacgccc agctcctggg 47340
agcaacttgc catgagcggg tcccctgctt tcccaccggc cgggccctga caggaagcgg 47400
agagtgtggc cccacccggg gtcccgcctc tgcccgtggt ccacacctgt ggcttcatag 47460
cctgggagcc acggtgagtc gaaggcctgc gctgtctctt ttggctgacg tgggtcctga 47520
tggtttgagc agacgggtgc tggcccccag atgagcaccg gggcagcctc tcaatggagc 47580
ctgtgagcaa gggcgtcgtc ccaagagaag cctgggacac agaggccatt gtttctatct 47640
cagcacagac agagctcctc cacctgtctg ctgtcctcgg gacacgccgg gagttggtcc 47700
ctgtcctggt tcccattccc cagggaggag gcccaggcgc tggcaggtgg aggggaacag 47760
ccgggcagag gagcggcagg gcccgtgtag cctcacaggg ctcactgggt ctcagccctg 47820
ggcctctggc tgccgggccg ggagcatgct gtgactctga ggagctagcg gagccctcca 47880
ggctaccagt gtccatgaac ctctgccgca gcaaggaggc ttgggccact ctggcaggaa 47940
ccaccaggcg ggtctacccc agccgggtcg gcctagagct gaccccagcc aggcctctgc 48000
agccacaggc tccctcccca ggtgccgctg cgtgactcgt gaagacagat cgcaccagtc 48060
acctgaaata cactgcaggg gaaaatggat cgttttcatc tcctttttgt ggtggtgctc 48120
ggagaagtgg gcggccacag ttcattaaaa attaaaagca gaggaggctt cattaatgtc 48180
tctggcatcg caggctccag tttctcaggg agtctgccag gccccagcgt ttctctgcct 48240
ccacgtggag ggtgccatct gtgcaggtgg gcactccccg ctgagctccg tgggggctac 48300
ccagattggg gcccacagcc cctcggtgag gggaccaggg tctggctggg ctctctccct 48360
aaggggggct cagtgctctt gtttctgggg tgccaggagg aggtcaaggg gcctcaaaga 48420
gaagctgctg ggggcgcgac tagtcccaga ccagcagccc tcgaccccac ggtgtctggg 48480
gaggaacttg gctgtccgga agccagtgag gtcctggcaa tgggcagggt tgcatctctc 48540
tgtttcctgg ctgtggaggc caaggggagc ccagggggac gcattggctt cgtggtcttg 48600
ccaggcagct gcagaggccc aaggcccaga ggtccagctg caccaggtcc acggggaggt 48660
aaagggagga gcaggagctc cttggaggcc tatgaccgat ggagggttgg gggcgtggcc 48720
ggagctggct ggggagatgg agctggctgg gtgttgcctt ggagtggagt gtggggcgat 48780
ggtcagggcg gagctgggca cccccgccta ggaggagtgg ccaggcagga gcccaaggcc 48840
cagagggagg tcagagggaa gaaacatcct gagggcagag ctgcaggacc tgctgatggc 48900
tctggtctag gggaggggag ggtacaggag cctgaggttg gtgggggatg gttggcctgg 48960
tgccatcagg aatggagaat tctgcctcgg ggagggggag ccggtggatg ccagagggta 49020
gagtggggct ggacggctgc cagcagagcc agttgggaag tcacccctgc gtggcactta 49080
attcccgggc tgggtgggag agaggcacct gtggcaagcc ctggggtccc ccaaggagaa 49140
cggagcggag gggagaacaa cagagctcgg ggaggccgtg ctgagaggcc cagggagtag 49200
aggagattct ggggtctggt caccgtgaag ggcatggtga ggctccctgc cggagaggag 49260
agggtgggag gcagtaggag caagtgaggt gagcagaccc cccgcgttga ggcttttgcc 49320
atggagggcg ggacagtggt agggaggcgg ggagggtggg ttcctaagct ccatgctttt 49380
agggcccggt ggtccctggg taccgccggc agtgagggga ggagggcctt gggagaccct 49440
gggctcagcc cccgggggca gctcccgcct cagccctgcc tgcccccctg acatggccag 49500
accaggccca gcgcagcctg gacctccagc atcctgtctg agcgaaagac atccattcag 49560
agagaaagac ggcggacaga ccccccaaag agacacttat gcagggaggg gcctccccag 49620
ccagggctcc aggcacacag aggagaggcg tggggcagga ggaggggctg agggacacag 49680
cagagctggc tacgctgagg ggttgcaggg catgatgggg cactctgggg gcagactgac 49740
cccccattag cactggttca gacgccactg gtctgtggga ggcttgtccc actgcctggc 49800
cccaggagcc ctgagtatgc ccggtggggt gacaagcctg cccccaggac ttggcctgag 49860
cctcctcttc agcatggggc aagggcaccc agagccacac gcctcttcct ggaccctgga 49920
cccttcttca tttcatttat ttatttatta ttcatttttg agacagggcc tcgctctgtc 49980
acctaggcta gggtgcagtg gcgtgttgac ggctcacttc agcctcaaac tcctaagttc 50040
aaacgattct cctgcctcag cctccccaga agctgggact acaggcacgt gccgccatgc 50100
ctggctactt tttattgaga cgggggtctt gctatgttgt ctaggctggt ctcaaactcc 50160
cggcctcaag cgatcctccc acctctgcct cccaagttcc tgggattatg ggcacgagcc 50220
actgtgaccg gcccctggcc ccttcttgag ctctgtaacc agcagaggcc actggggcag 50280
atcaaggcag gtgctgggac tctaccaagg cccctcccgc ccgccccaca gcagccccac 50340
cacgaaggct gctgcacaca cctggtccac accacttacc ctgagtgttg tgagctttgg 50400
gaaacatcga atgttttaat cactttcgga gatgttgggg tcaccagccc caggccaggc 50460
agtgacatca aattctcaga ttcgattgat aggagccagt gcctgctcag aggggaggtg 50520
aggctcacag cccacccact gggtgtcaca gcctcctgcc ctggtggaca gtgacaagga 50580
aggggttgag gcaggaacag gggttaggct ggtgcttacc tcccccgact tctggacagc 50640
tgccctggga cctctgcttg aacactgcct cctccacgca gccgtccagg atccttccag 50700
gcagcacaag tcttcctcca ggctccgctg tctgtctgcc ctactgtgtt gtggccctcg 50760
cgctgcactg ggcagggggc ccatgctgag gagctcactg gactgcgtgt tctgccccca 50820
caccatccct gagggaggcg gggcacctct ctttgacccc agggagcaag gccaggcacc 50880
ggaggcagcg cccgagggct aaggcagccg actgatagga gcagacgtca tggagggcac 50940
agggccatgg ctgggagcag ccgagggtcc catggaggac agcccagcac cccagggcac 51000
gggccgttta gggggacatg tgctccccct tcccagagac ggccatgcct gctgcaggaa 51060
ccctggctct gggtcttgct cctgtctgtc ctgcaggctg gcagcattgg agttttcctc 51120
tcaggggatc attaaaccct ggcctagcct ggcccgcatc ccagcacagc cgggcacagg 51180
agaccctgcg tccaaggctg gggcagtggg ggcagcagcc gtccaccccc aggctccatc 51240
ctactcttgg tggccagcct gggtcatgca ggtggccacg gtaggtgagc cacgcaatct 51300
ccccacccca cctcacccca cctgccaccc ccggcaactg gcacactgtg gtctcttctc 51360
aggaccgccg gggcccggtt ggaggccaga gggctgggtg gtaggcccca tgagcagcgg 51420
cgtgcatggg ggttgagggg tgtctgggaa ccagtggctg gggccatagg tgagcctgag 51480
ggaaggggag cggcactggc tggaggggcc ccacagctgg cctgcgaggt gggtgcaggg 51540
atgaccactt cccaccagcc catcttccct gacagccctt gaggctgcag tggcccatag 51600
ccttggagca cagccaccag cggcctccag acagagcagc tgaccatcag ctgtggacag 51660
cctgtatgac gcaggtccta cggcatgttc tgagcacttg cggtgtcctg agcaccatcc 51720
ccagggccat atgggcaact ttacctcctg gcaggtgccc tgcacccacg gaggcttggg 51780
cgagggtgtg tggagtgagt gccgcaccct gagccccaac agggcggcct ggagggccca 51840
gactcacagc agcgagtgcc cagggctgcg gggaggaatc ttcagaggag ccgaggctgg 51900
gtcggctgtc tgctgggtgt gacggacccc aggaccctcc tgggtctgag gtggagggag 51960
tggtcctgct gggccctgac ttctcaactc ctgcagttgg aaagttggaa gaagtcagtc 52020
aggttggggc tcccggcgtg tccccagcct gagtccccac tggccctgag cctccatgcc 52080
cctctctgct tcttcagggt ccaggtggag ttctacgtca acgagaacac cttcaaggag 52140
cggctcaagc tgttcttcat caaaaaccaa agatcgagtg agtggggtgc ctggagggcc 52200
actcccaggc agggaggtgt tgagggcgcc gggagcaagc ctggcgatgg cgaaggctgg 52260
ggctgtgagc tcagggagag tccatggggt gggagccacc tgagtgctgc gggggcattt 52320
ggaagcaggg tgggggtggg tctgcatggt gagtggggca cagggtagcc ccctcttagc 52380
ttcacactgt ctgagaccag ggcctctgca gcgggactcg tggggacacc gtcctgcctg 52440
ctggacacca ggctgggtgg ggcaggacca tccataggtg ccagcaaggt ctcccctgtg 52500
gccacgccct gcctcccacc cctccataca gccccaccct ccccaacagc tccctgcccc 52560
gttcccagcc agagcttggc atcatgctcc ccccgggatt gcaggtgagg acttgggggg 52620
tttccccagg ggctccacat tcacctgcct gctccccaat ccctatcctg tcctccaaga 52680
agtggagtgg cctctagaaa tcccctgcac cccaagttca ggcacctgta aggtggggcc 52740
agggacagag cctcttggag gctgacccaa gagcatcagc ccccaaacaa cgcagggcac 52800
acagagctct gcgtgcagcc cgggtgtggg aggggagccc agctggggcc atccagagag 52860
cccagccaga cccgggtgca ggccctgctc cccgaagccc agagctgggt cagagccctg 52920
aggccgctgc cctccccgca ggcctgagga tccggctgtt caacttctcc ctgaagctgc 52980
tcacctgcct gctctacatt gtgcgcgtcc tgctcgatga cccggccctg ggcatcggat 53040
ggtgggccac gtgcgcggcc gggcgcgggg tcccgggtcc cagggctgag ccttcccact 53100
gggccgttac agaagctgat ggcgtccctg ggggagcccc tgtgcctggg gccttgggga 53160
gtccttcctt ccccagtgcc tgtcccagga tggaaaaagc caaggactca gtgcccaggc 53220
tcccgcagac ggctcagcgt agggagaagg gtccccatcg tagacttcca gctgtgccct 53280
tagctactag cggacccaga aggtccacgg aaaggctgga gcatctagga tgtccctccc 53340
tgcccccaca agtgtctctg tgctcacttg agcttctgca ggtcagggaa gggggcgccc 53400
agtccccctg gggaaagccc ctacctgttt ctgggggtgt cttctacccc tcctgggtcc 53460
caaggagtcc cctccccagg gcccatcgtc ctggggccca tgctccaggg acttctggga 53520
gaggtgctgg gggcagcaat ctgcaccgtc aggtccttac cagcctcgca gcagccgcga 53580
tgagggtggg tgggaacttg ctctctctga gtcctgttct gtctccttct gctgttgctg 53640
cttcgagaag tggcggctgc tgggacctac tctgtgccca gcgtgccttg gcaactcctg 53700
ctcacctctg tgtgggtccc aggggacatc agcagggccc tgcggccctc ggtgccggcc 53760
tgtcctgagt catgtctttg gggaccagcc cccaacccca ggcctctctc tctggctccc 53820
tggcactcgg atgctgtgct ctgtgtcctg tttcttctct cccctctcct gcctcgttcc 53880
cttgttcact cgtccacttg ttctgtcctg cctcctggtt tccagaaatc ctttctctga 53940
atgtccttcc gaagatggtg tctccagtcc tttcctgttt tacgctttcc ccatctgctg 54000
ggcctgtttc tcccgagctc acattgggcc ctgacttttt catacccgta gatttcctca 54060
aatgtctggt gccgtttatg cgtaagagtg ctcaggcgct gaggggctct gcagccacgt 54120
gtgtggtgtg gttgtcacca tccagccatc ggggtgaacc ctgccagcat gctggtcccc 54180
cctctggctg cgcagagcag gttcttccct ggagagaagg cctgactgcc gggagcctgg 54240
cttctgggga cctaaaggcg tccatgtaaa cttttgctca atcccccttt tcacctgtta 54300
ccccgtcaca agggggcctg gcatccccag gccagagact ttccctctcc taagaatgaa 54360
cctcctgtct ttgtctaggt cagaagaggg cagaacccac taggagagtt tgagaaggag 54420
aactgggccc tgactgactc tcaagctact ttcctaggtc actccccacc ccaagtccca 54480
gggtcccctg gggcttctgg tttcacatcc ccacagggcc caagtctgtt gtgttcactg 54540
cccgtcccct agcacagcgt ccaggacatg gatgggggtg ggaagatggg tggatgatgg 54600
atggatggtt ggatggatgg tggatgatgg atggatggac ggacggacgg atggacggat 54660
ggatggagtg gatggaggga tgagtggatg ggtggataat ggatggatag gtggatgcat 54720
ggtgggtaga tggatggatg gatggaatag atggatggag ggatgagtgg atgggtggat 54780
gatggatgga tggatggatg gatgatgcgt ggatgggtgg agggatggat gttggatgga 54840
gggatgagtg aatgggtgga gggatgagtg gatggatgga gagatgagca gaaggatgga 54900
gggatgagtg gatggatgat ggatggatgg atggacagat aagtagatgg atagatggat 54960
gagtggatgg atgatgagca gatggttgga gggatgagtg gatggatgga tggagggatg 55020
gatggatgga cagatgagta gatagatgga tgagtggatg gatagaggga tggatggatg 55080
agtggatgga tggaggaatg agtggatgga tggagagatg gatgatggag aagtggatgg 55140
atggatgagt gagtggaaag atggatgggt ggatggatga tagatggatg tccagatact 55200
tctgtgggca cttagtttgc aacaacccca ttaaaaatca ggggaaagtg gatcagttga 55260
aagaaaagac aagaggagct ggccatcacc aggggccttg tgagcagtga ggtctccttg 55320
gtcagtgacc ctggcatcga tgatggtctg ggacaaaact agcttgttgg ccatgccctg 55380
gtcactgtcg cagcagctgg ttccaggtgg cttgggggcc gcttgtcctc agaagcagct 55440
tagggacgtg cctcttggag tcagcacctg gggataggag cttcctctcc ctgtctcttg 55500
aacactgtcc agccttgttc aaggcagctc tggccttggg gaggccctga gtgttcccac 55560
atgctctctc tggccatgta aggcccctcc ctgggagcct gttgtcagca caggcagaac 55620
cagtgtgttg ctgttgggtt ggggctaccc ccaatcccgc agatgtggga tgtaccctcg 55680
ctgtctgcct gctgggctga gcagtggcca gcccagcatt cctcagttag aggccctcct 55740
gcaggatctc cgcagtaggt ggggaggggg caggctgcct tgtctcccag gtgttagagc 55800
tctgatgtgg gggttagccc cgggtgggtg agtaggaggc ccccatgaac ccgagcctgt 55860
ggaagccctc gggcagcaag tccttgcagt ggtgctagag gggccagggc cgggccagcg 55920
ctgtgtctct ccacagctgg ggctgcccaa agcagaacta ctccttcaat gactcgtcct 55980
ccgagatcaa ctggtgagtc cacactccag ctcccaatag ccaggcgctc agaggcctgg 56040
gaccagggtg gggtgggatg agtctccact ccagctccca atagccaggc gctcagaggc 56100
ctgggaccag ggtggggtgg gatgagtctc cactccagct cccagtagcc aggcgctcag 56160
aggcctggga ccagggtggg gtgggatgga cagaggctca cactgcctgg tccctgaggg 56220
ataatgccca gcctcaaccc agcagccacc caggttcccc aggacacatg tgcccttagc 56280
cctggctgtg gtcaatgctg ggaatgtccc cttcaagagg agcagtttga gaattgtgag 56340
ttcccagcca gttccacagc ctccacacgc tcttcctgag cccagtgaga gatgcaagga 56400
agcccgtctc ccagtgaggt ggcggcttct cttccagttc accatcttac ggcaaaggaa 56460
ggcacctgcc ccgggcaggc agtgggaggt gactgcgggg caactggggt gcctggtcca 56520
gagattaaga cctgtcccca gaacctgcaa ggcatgtccc cagtgcctga gcccctgtcc 56580
gcatcaggca aggagcagat ggccccctgc agccatgccc ctgcctgttt atggatgagg 56640
aactgagact cggggaaacc cagggggctg tgggttagat agcccgacct ccctgctctt 56700
agggacattc atgggagccc ggcttcaggg acccaggtga aaaaaacagg ctacccagtc 56760
tggggcccag gctgctgttg cctgtcgtgt ccagagagga gaagctttgc cacccttggt 56820
agtgtcatgg gctgcaggcc aaggctccat ggagactcag ccatgggccc tggcctcaca 56880
agcacctcct ggggggcctg cctgctgcag tcctgctcca tcctcctctc ttggggaacc 56940
ttcccttccc tcctccttat ggtcccctcc aaaggcaagg taggctcctt tggtccagcc 57000
ccaatgagca gcacatgctt ggggccagtg gaggccaatg gttatggccc cagccccagg 57060
gtggctgggg gacactagtg gctgtggtgc cctactgtgc tgcctccttt ctcttcccag 57120
ggctcctatt ctgtgggtgg agagaaagat gacactgtgg gcgatccagg tgagtgccct 57180
accctgcccc cctcccgact gcagtggtgc tcagtaagca ctgaggacca acccagactc 57240
agtaagtagg gaacccaggc tcggtgagca ctgaggacat acccagtctc agtaaatgct 57300
aagaacaaac ccaggctcag tgagcactga ggacagaccc aggctcagta agcaggggac 57360
ccaggctcag caaatgctga ggacaaaccc aggctcagta aacaggtgac tccaactcag 57420
tgagcactga ggacaaaccc agcatttact gacccaggct cagtaaatgc tgaggacaaa 57480
cccaggatca gtaaacaggg acccaggctc agtgagcact gagtacagac ccaggcttag 57540
taagtagggg acccaggctc ggtgagcact ggggacaaac tcaggctcag taggcagggg 57600
acccaggctc agtgagcact gaggacagac ccaggctcag taagcaggga aaccaggctc 57660
agtaaatgct gaggacaaac ccaggctcag taaataggga aaccaggccc agtgaatgct 57720
gaggacaaac caagactcag taaacaggtg actcagggtc agtgagcact taggacagac 57780
ccagcattta ctgactcagg ctcagtaaat gctgaggaca aatccaggct cagtaaatgc 57840
tgaggacaaa cccaggctca gtgagcactg aggacagtcc caggctcagt aagcatggga 57900
cccaggctca gtgaatgcca aggacaaagc caggctcagt aaaacaggtg actcaggctc 57960
agtgggcact gaggacaaac ccagcattta ctgacccagg gtcagtaaat gctgaggaca 58020
aacccaggat cagtaaacag gggacccagg ctcagtgagc actgaggaca gacccaggct 58080
cagtaagcag ggaaaccaga ctttagtgaa tgctgaagac agacaggctc agtaagtagg 58140
gaacccaggc tcagtgaatg ctgaagacaa actcaggctc agtaagcagg ggtcccaggt 58200
tcagtgagtg ctgaggaccg acccaggctc tactgctctc cacacaattt tcccagggat 58260
ccctgaggac ttcctgaccc cctctgtctg cttcaccacc tgaatctctc cctccactga 58320
cccatctgtg tccttgctgt tttcctgggg tggagagtgc acaggccagg tccctggctg 58380
gctcctgggt gggtgaccta gttcatgact gggtcccatg tctccatctg agaccagaga 58440
gggtctttca cacccacccc tatcatgttc cagaggggtc agtagatgcc tgtgctgaga 58500
ggggttccgt gggggaaaac caggtccact gagcctccat ctccgttccc tccccaccag 58560
ggcagcggga tagccgctct ctggtgtctt cctgagcgtc ctgcctcacc cactgcaccc 58620
tccatcccac cctgggccta gagtgggcgg cccaggagga ccatggtttc aagactccat 58680
ctgccctcgg ccctggcggg ggtcagccaa aggccttggt ggctaagact gtcctgacat 58740
gggagtgagg gtcaaggcag accccagaca cacacctggc tttgtgtggt acctgcccgc 58800
gaggcctgtg gggtcaggcc ccagccccag ccccggcctg ctccagagct ccttcccttt 58860
cctgactccc aggtcatcgt ggccataata agcttcctgg agacgatgct tctcatctac 58920
ctcagctaca aagtgagtgc ctgcccggga tggcacctca cagggggtcc ccaccctccc 58980
caccctcccc agcctccccc acctccccca ccctctccta tttccccaca cttcccagcc 59040
tcatccactg acctccaggg tgggctcctc gccctcttcc ccaccctgcc cctcccctgc 59100
tgggccccac ccccaccctc catcgccccc gctgataccc cccgtttggc cccagggcaa 59160
catctgggag cagatcttcc gcgtgtcctt cgtcctggag atgatcaaca ctctgccctt 59220
catcatcacg gtgggtgagc cccagctgcc aggagtgcgg gccctggagc cccagccctg 59280
acctgtcccc ttcacagatc ttctggccgc cgctgcggaa cctgttcatc cccgtctttc 59340
tgaactgctg gctggccaag cacgcgctgg aaaacatgat tgtaagccgg ggcggggggt 59400
gcagctggga cttggggggg ccaccctcag cctcaccggc cctggaagac actgtgcgac 59460
gtagcctgcc acgccccggc cctggcatga cctgtagagg accgggaagc cagggcagca 59520
gaaactctgt ctctgctcct ggaaaacatc caagccaagc cccgaatgcc ctccttccag 59580
gaagaaactc aatcccagag cttttcctaa gcctggaaat gaaatggctg gcaggaggag 59640
gagggacaaa gtgaagggtg tgacaaaccc aggccacgag gaccagggcc acaaacacca 59700
ggccacacgc aaactggggc cacggggcca caggcaggcc ctgtgctgag catctcagga 59760
aacctgggcc acggggccac aggcaggccc tgctctgagt gtctcaacat ggtccctgtc 59820
atgtgaatgg cagcagtcag ttccctaggc gcccaccctc tccaagccag accccttgac 59880
tcacagcccc cattcctgcc ccagtggtaa atcagcgtta ccatgctggg tccaagcctt 59940
gcacactaac cagccctctg acctgagact taagcctcat ccccggggat gtaggcaaga 60000
tggggacccg tcctgagaga ggacagcaga gggggtgccc tacccaggtg caggctgccc 60060
gtgggcctca gcggagacgc aggtgtggcc aggcgtgggc tgccccttgg gcctcagccg 60120
agacacaggt gtggccgtgg gctgccccgt gggcctcagc cgagacacag gtgtggccag 60180
gtgcaggctg ccccgtgggc ctcagccgag acgcaggtgt ggccaggtgc aggctgcccc 60240
atgggcctca gccgagacac aggtgtggcc aggtacaggc tgccccgtgg gcctcagccg 60300
agacgcaggt gtggccgggc cgtctgcttt ccactgtcct tctagtctct attcattggc 60360
tcctggcggg gtccacagtc cctgcccgct gacagccacc actccttcca cagaatgact 60420
tccaccgtgc catcctgcgg acacagtcag ccatgttcaa ccaggtcctc atcctcttct 60480
gcaccctgct gtgcctcgtt ttcacggggt gagtgccggc cgtcagtgtg agcaccccag 60540
gacgttggga gggcccgaga ggcaagcagg gccgggcgag gggatacaga tgcctatgtc 60600
caagctatcg gggcagaaaa ggccacagtg cctgggctgc gggtgtcggg ccaccaagct 60660
gggactgagg tcaggaggca gctccaagcc cacgtcccca gtacacgagc agccctgcag 60720
cccgactcct ccaaggacag agatacccag atctggcttc ctggtctatg ccatggacgt 60780
agagaagggg actggcccct aggccaggtg gggtctcttg gctgaggccc agctgaaagc 60840
agggtctgga ggcagccagg gtaaaggtgg gggtgcccag agctgcgagg gcctccagcc 60900
cacccaggca tgcccactgt gcccacctgc ctgtgtcctc gtggagggct ccatgttgct 60960
gctctgcctt gggtcccagc gaggcctggt caccacttcc cgtccccagg cagggatgtc 61020
aggcaagcac tgtgccctgg gggagggaga gtgccctgcg tttcccgcct cccttccccc 61080
ctgcccctca tgacagactg acagacacag agctgagtgg gcagattggg gcatccatga 61140
ggatagcatc tgggacctgg cggcgacccc agccctgccc attagacctc ccagcctcag 61200
gcctgggcgc ttgtctggct gtgccgggca gaggcctgag tgtggtgggt aaaggggcaa 61260
ggctctgaga tgggggtaga gggccagacc ccaggcccac ccctgtgtca cccaagccca 61320
cgctgatgac acagccctgc atcccctgct cccagagaat gttccaggga cctaggagag 61380
agccacccgg caggcaggga ggctccgggg aattcgccgt gaacagaggc cgccatgctg 61440
tggccaagct gcattgtcag ccagcgtcag gcaggaggtg gctccggcag agcttgggga 61500
cagatgggca gggctgaggg cctgatgcca cccagctgtc aggagggcgg ggctcgcctg 61560
gtgatgcaca gctcagtctc ctgggcagtg agggtcccgt gggcaggcag gatctctgag 61620
gggccacggc cccccagctc ctgggcccca ggccgcccct cactgccagg ggttgcagga 61680
cctgcggcat ccagcacctg gagcgggcgg gcgagaacct gtccctcctg acctccttct 61740
acttctgcat cgtcaccttc tccaccgtgg gctacggtga cgtcacgccc aagatctggc 61800
catcgcagct gctggtggtc atcatgatct gcgtggccct cgtggtgctc ccactgcagg 61860
tgggtcctct gggcaccagc cctgggtggc accagcaaag ggacaggcgg gtgccagtag 61920
agggagggtg ccactgaggc tgtggcacag tgcgggggcc actcccagga ggggacagtg 61980
aggccaggcg ggtggtgcct gctccgttgc acgcccccac tgagggtcta cggcgggtcc 62040
ggtggtgctc agcatggtgg gtaatgatgg agtcccgtga gctggcctct tccttctggg 62100
gagatggtgg gtctccagtg ccagggtgac ctgcccctcc caggcccagg cagagtgcag 62160
ggaagggtca aggtggacag ccggcccatt tcccatccac agccaggtgc agcagcagct 62220
gccaggccca cagggggcac acccccccgg ccaccccagt ggcttccccg tcaccactgc 62280
tgtggcccac tgcccactga gcagaggagg ggacggggca agacctcagt gggaaaggtg 62340
gaggcctgga gagggcagct gcctcagggt gtgaagtgct tgggcctgga ctgcctccga 62400
cacctcctcc aggcacccca gcccaccctg gagggaccct gctattgggg agatgggaga 62460
aggaggggac ccctgtgggt ggtggaacat tttccaggag gctgggtagg aggaagagcc 62520
tgaggaggtg gccagggcct tctgggagac agacccccag gtggctgcag gatgccgggg 62580
agacagggca gtgctcctag ggagcctctg ctgaccccag gctcagcccc agctccctcc 62640
cgctaaacag cagtgggcgt ggcccaggta tgggcccagg ccaggcctgg ctcttctcct 62700
cactatatcc aagccaaagc tgtggcacca gctgtacggc ccccagcgtg ggccatgttc 62760
tccacatctg tggcttctgt tctcctgagt tcagatgggg ccgtgcgcgt ctttccatct 62820
ggttgtcggc cactccaccg tccagtgcca cgagtcccgc tcctgtgagc tgcccgctcc 62880
tctttggtct tccccctggt tctcgctgat gagcgagtct ctgtgttcta gaagaagcca 62940
gttgtgtgtg gctttcccgt tacttcctgc tctgtgaccg cccctctcac tttgcttaca 63000
gaatcttcca ttcacggatg gtcttgattt ttttttttta aattagagat agggtctcac 63060
tctcattttg ttgcccaggc tggcctcgaa ctcctgggct caagcgatcc tcccgcctca 63120
gccccagaaa tagctgggat tacaggcggc ttggctttga ttcaccaatc tttcccttat 63180
ggtttctgtt ttcctgtctt tactgaaaag atcattccct ccctcgatca taaacctggc 63240
ttcctatttt cttctaaaag tgtaaagctc gcctctcacc tggagggttt cacccaccag 63300
gaaccaccat gtggggtggg gtggagctgg gttctcccct ctgacgcctg ctcccccaca 63360
ccctgcattc tgctcctttc tctgcgcatt tcataaccag gcaagggcgg gagtgagggt 63420
gggagtgagg ccaggagcac agtgtggggg gcactccgtg cagtgacact gcctccctcc 63480
tcggccctcc tgccccaatc cgtaaatctc acctcaaatt ctttacctta attacttctg 63540
caaagaccct tttgcaaatg aggactcatc ctgaggtgca gggggacctg ctttcagggc 63600
catccttgac cttgctacgg gcccccagcc tccgtccctg gtccgccccg gcccacactt 63660
caccacgtgg ccggcacctg ctgaggccgc tgcacccaga tgctctgcag aggcgttgac 63720
ccatccagtc tctgaattcc ccacaagccc ttccagagaa acatccgaga ggcccctggc 63780
ccagccgagg tcagaggaag ggtcaacagg gccaatgcgt ccccctttcc cctgtgggcc 63840
cacggcccag ccacacgcag ctccaccttc gggctgcgtc cggctcctct ccccacccca 63900
cacaccccag agcgaagagg agccccagcc ccagccaccc ccagggtcgc tttcaaataa 63960
agcaggagcg aagcgctctc tcccgtgctt ctcacgagac cgtggcaccc acgggtaagg 64020
gccaaatcgg gatgtgcagc aggcctgttc catgtccctc tgctgcgtcc acagcctccg 64080
ggccggggct gccttcccat tctgctcctg aagcaccagg ggagccccca cctcccctta 64140
tctccattaa gaagtaagac aaggccaggc gcagggctca tgcctgtaac cccagtactt 64200
tgaaaggcca aggcgggagg atcgcttgag cccaggaatt tgagatcagc ttgagcaacg 64260
tagagagact cccatctcta ccaaaaagta tgaaaattag ctgggtgtgg cggcatgcac 64320
ctgtagtccc agctacttgg gaggctgagg caggagaatc gcctgagccc tgaggttgag 64380
gctgtggtga gctgtgatct cgccatcgca ctctagccta tgcaacagag agtgagaccc 64440
tgtttcaaaa agaaaaagaa aaaagggcca ggcacaatgg gtcctgcctg taatcccagc 64500
actttggagg gccgaggtgg gtagatcact tgagatccgg cgttcaagac cagcctggga 64560
aacatggcaa aaccccgtct ctaccaaaaa ataggaaaaa ttagccaggc atgatggcac 64620
acagctgtag tcccagctcc tcgggaggct gaggtgggag gatcacttaa gcccaggagg 64680
cagaggttac agtgagccaa gatcacacca ctgcactcca gcctgggtga cagagcgaga 64740
tgccatctca acaccatctt aaaacaaaca agacaaggtg actccaggtg caccaggtcc 64800
tgcaggcatc acacctgcac tgctcttcag ggaaattcac ggaacaaatg cgccatcgtc 64860
acgagaactg attgcatcga tgggtatggc catggtgaca agtgaccgac agcccagcag 64920
cctgcacgca gaggtgtcac tgtagctcga gctccgtgtc cacagtgggg tccctcagat 64980
cagccactgc ctgactgcct tgtctccttt ctcccgtgtg gggcaggcag agcaggccct 65040
gagtgggaca agctctgagc gaggcaggga ggaaggcggg ggcagggcct gggggctggc 65100
gcaccctccc tcccatcagc cctgccggac ctggtgctca aacctgaccc aggtgggcct 65160
gtgctgtccc tggcagggct gggggtgatt gggacagtga tgccgctgac cccaccgtct 65220
aagccgctcc ctgcctcctc cgaatgactg gaaagactga gcctctcact ggcgatggta 65280
agggtgggct gcagtgccct tgcccttggt ctccactggg ctgaatgcac cagtaaaagc 65340
ccttgaagca gagtgatgac cccgaggccc tcgctcacga gcgtccttct ggaacacagc 65400
agcgccggct gggtctcctg gaagtatcct ccaggctctt cgatcagcaa gacagacagg 65460
cagcttaaac agcagatatg tatcctccgc cagccctgga ggacagaatc ggaagtggag 65520
gggttggcag ggctgaccct atcaggccgc tttgggggag attgtcccat gcctctctcc 65580
agcttctggt ggggccgcaa tccctggggc tgcttctacg gtggctgtag aaacctcagc 65640
ctctgccccg tgtgcacttg gcctcttctc tgtacctctc actggattta gggcccactc 65700
caacccaggg tgaccttatc ttaaatcatt acatctgcag agacctattt ccaatcagat 65760
cacatggcga ggttctgggc agataggact tttagggtca ctacggagct gccgtcatta 65820
gctccttcat cctcacggcg gccctggagg gttgccgtgc catgcagcca tcttgtaggt 65880
gaggaagctg aggctcagag tgggggacgt gagccctggg gtgtctgaca gcagagcccc 65940
cgccagcacc atccgcgggg aagcctctgt tccggtcgcc ctggagtctt gagcacctcc 66000
cagctgtgga aactgttttg tgtggcaagg cagtggagcc tcgtcaccgg aacaaagcag 66060
gcgctggata agtgcaatgc gatggtccca tttagaccag acgatagcac atcagccatg 66120
cagcccacag tccatgggag ctcctgccat tgttcattta acacgtgttc aacaagccgg 66180
gcaccatgac tcagcctgta atcccagcac ttcaggacga caaggcagga ggatcgcttg 66240
agcccaggag ttcgagacca gcctgggcaa tgtagtgaga ccccatctct acaaaaaata 66300
aaaataaaac tagctggtca tggtggtgat gcacctagaa tcccagctac tcaggaggtt 66360
gaggcaggag gatggcttga gcccgggaag tcaaggctgc agtgagctgt gattgcacca 66420
cggcactcca gcctgggtga cagagtgagc ctccgtctca aaaaaaagaa aagccaaaga 66480
ctttcaccta gaggccagtg gggccggtgc tgggaggccc cggtggcctc tgttttggat 66540
ctgtcccctt tgagtctcaa cacccagagc ttgcatctgg ggagcatgag ccagggcagg 66600
cagcatcctc agaccagcag cctcaaacca cctgcccccc agacataggc tcctgacagt 66660
gaggcctgcg agtgcctgga agaccggggt ctgaggcctg atttggccac gcttaccatc 66720
aagagagtga tccccaatcc cacgggctga gcctccccac cctcggttta ctccacagtc 66780
tccagccgcc cctcctccct tggtccccac acatcctgcc agccgggcct gcgtcctgct 66840
ctgtgtcatc tgaggctatc agcatctaca gtttccatgt gggaaaggcc cccctaatgt 66900
aggtgtcacc ccccggccgg ccctgcccca ggcccctaac agacagtcgt gtgtcagggc 66960
ccaggttctt caccgggagc cctcgctccc caggcctggt cgctggtgct cacctgtttc 67020
tcacctgcag ttcgaggagc tcgtctacct ctggatggag cggcagaagt cagggggcaa 67080
ctacagccgc caccgtgcgc agacggagaa gcacgtggtc ctgtgtgtca gctccctcaa 67140
gatcgacctt ctcatggact tcctgaacga gttctacgcc cacccccggc tccaggtgag 67200
gccccttacc gtggcccagc agacgactcc ctcccggccc ctagagacgc catcctctcc 67260
ccaggactgc ttggcaagtc cctgagtcct ctcagccttg gtttacccct tcagtgaggg 67320
cagatgcctc cctcccggcg cccagagacg ccatcctctc cccaggactg ccatcctctc 67380
cccaggactg cttggcaagt ccctgagtcc tctcagcctc agtttacccc ttcagtgagg 67440
gtggcagccc acagtcaggt ggaggggccc tgcgggggcc cctcttttcc ctcccaccag 67500
atgcaagatc acagtgagct ctagggccca gaggtggtgg gcacaaacac agtcctgaag 67560
gcagggccgc ccgggcgggg caggggctgg ctcagagggt ctgaccctcc gcctggccgg 67620
caggactatt acgtggtcat cctgtgcccc acggagatgg atgtccaggt gcgcagagtc 67680
ctgcagatcc ctctgtggtc ccagcgggtc atctacctcc agggctctgc actcaaagac 67740
caggacctca tgcgagccaa gtgagtgctg gtgggcggag ggggtggcat gggggcacct 67800
tcctgagtca ggtcggctgc tcagggctga ggcattgacc gtcgctctcc tggccaatga 67860
gagccatgag agcattatag actatcccca gggtggacca tctaggtgga ctgtccaggg 67920
tggatcgtcc ggggtggacc atttagggtg gatcgtctgg ggtggaccat tcagggtgga 67980
ccttctggga tggaccattt aggtggacca tacagggtgg atcatctgga gtgaactgtc 68040
aagggtggac catccagggt ggaccatctg gggtggacca tctaggatgg actgtctggg 68100
gtggaccatt cagggtagac cttctgggat ggaccattta gtgtggacca tccagggtgg 68160
attgtctagg gtgggtcatc tggggtgaac tgtccagggg ggaccatcca gggtgggtca 68220
tctgggatgg actgttcagg gtggaccatc cagtgtagat catgtggggt ggaccatcta 68280
gggtagactg tccagggtgg accatctggg gtgggctgtc tggggtgggc cattcagagt 68340
gaaccatctg ggatggatct ctagggtgga ccatccaggg tggatcatct ggggtggacc 68400
attcaaggtg gaccatctag ggtggaccat ctggggttgg tcctctgggg tagatcatca 68460
ggggcggacc gtctggggta taccctctgg ggttgtctgg ggtgggccat ccatggtgga 68520
ccctcttggg tggaccatct ggggtggatc gtctggggtg gaccatccat ggtggaccct 68580
cttgggtgga ccgtctgggg tggatcatcc agggtggact gtctggggtg gaccctctgg 68640
ggtggattgt ctggggtaga ctgtccgggg cctcttgcag tttctctagc tcaggtccca 68700
ggcccagatg agcaggaccc tgcagccagg cccttgtccc tgcaccatac ccactgtgga 68760
gcagcccagg caagcccaac ccagctaagt ctctgtctcc cttttcaggg tgaggggcag 68820
ccttttgcga gctccacctt cccctgctcc aagtctaggg aaatctttgt caagttctag 68880
ggaggctcaa aatagaacag gggcgggaga gtcagctgct gtgagtcaag gtgggagaac 68940
gggctgaagg tagagttcct tttaaagaca aattgacaga gtgacaaggt aacaagagta 69000
tattattacc tggaactttc cagaatgtgt cggtgcactt tctgggacac tccctggaaa 69060
accctcctgg tgacattttc attccaggag cctgaatgtg tccttagtgg catagtgttg 69120
gtggtactcc cagggtctct cctcatcact ccccctcccc ctgccatgtc cagagcccca 69180
agctggaacc cattgcctat ggaacgccac ctcttttgtg gtcccgtccc cagcacacac 69240
aggcgatgca cctgcttggg cccagggagt ggggagaggg caagggcgta ggccattccc 69300
agccaggcag ggatgagccc agggctgtgg gtacagggcc tggggcccct gcggagcaga 69360
cagtggtgcc agtgatgtgg tggggttccc tgccctgggg cagaggcgac agtttcttag 69420
acagcgtctc agcagtgcta ggtggtttct gcagctgggc tttcaggaga cccaggaggc 69480
gctggaagtg accacccagg ttcccagacc acagagtagc caggccaggg agcggacagg 69540
gtctctgccc ccagattccc ccctccctcc tgcaccccaa cccagccctg ggtgaatgtc 69600
tcatggcaac atacaagatg ggtaccccgg aagccagtgc ccaggtcact ggcacacacc 69660
taggtggggt ctccaccggg cctgctcctg ccaaccctgg acccctagcc cctgacgcct 69720
gggagtatgg acaaatccag gcagccccag ccagcagagc cccctcgcac gacctcctga 69780
tgcccctcct acctggccaa cttagggaca agctgggggg ttgcttcaga gaacagggcc 69840
tgggggagga agggcaggca ctgccctagg aagcaccatg ggctcccact cagggccgtg 69900
gccaggagaa gctgtcagct ggtgtctcca ggacacacca tccatagcat ctgaccccct 69960
gcccccaccc gctgtcagcc tgcacacact cgggggacag gtgtggctcc tgacccctgc 70020
ccccacccgc tgtcagcctg cacacgctca ggggacaggt gtggctcctg aaccctgccc 70080
ccaccctctg tcagcctgca cacgctcggg ggacaggtgt ggctcctgtg ccttctcgag 70140
tgtcggagct tggagtctcc tagggtgtcc aggagtcctg acccggctca gagcctgcca 70200
gggatgggcc agggagtctg gagaggccca ggatgcctgc gggggggggg gggggggcac 70260
tgggataccg gtgggggggg cacagggatg cctgctggtg gagggcacac aaggatgccc 70320
gtgggggaca ctgtgatgtg ggttgggggg ggggggggca gtatggggat gcccactgag 70380
ggggcactgt gactcctgac cagcagagag taggggcctc ctcccgcctt ccatcctccc 70440
cgccttccat cctctccgcc ttccatccag ccgtcctctc agtctctttc tgtgcacctg 70500
ctgcaccagc ctcctcccag aggaggtcct ccccacctca cctccgcacc cccggctgca 70560
ctgcccacct cccctgctcc acccacgctc aggccctggt gcattgcagg atggacaatg 70620
gggaggcctg cttcatcctc agcagcagga acgaggtgga ccgcacggct gcagtgagtg 70680
aggctgaggc cctgcccagg cgggaggggc accgtggggc cggggagcgg gggtccctga 70740
gggaagagac ctgccccagg ctgccggtgc cgcccagcag cccacagagg ccagcccgtc 70800
tgcactgacc aaccacccac cccgccagga ccaccagacc atcctgcgcg cctgggccgt 70860
gaaggacttc gcccccaact gccccctcta cgtccagatc ctcaaacctg aaaacaagtt 70920
tcacgtcaag tttgctggtg cgtctggggc acacgtgggt gatggtgtat ctggggcagg 70980
gcacgtgtgc acacgtgggt gatggtgcat ctggggcagg gcgcatgtgc acatgtgtga 71040
cggtgcgtct ggggcaggac gcgtgtgcac acgtgggtga cggtgcgtct ggggcaggat 71100
gcgtgtgcac acgtgggtgt cggtgcgtct ggggcagggc gcatgtgcac acgtgggtga 71160
cggtgcgtct ggggcagggc gcgtgtgcac acgtgggtga cagtgcatct ggggcagggc 71220
acgtgtgcac gtgtgtgtcg gtgtgtctgg ggcagggcgc gtgtgcatgc tgttgggtga 71280
tggtgcgtct ggggcagggc gcgtgtgcac acgtgggtga cggtgtgtct ggggcagggc 71340
gcatgtgcac gcagttaggc gagctgtgtg gggcagcggg aggggctggc cctggagctc 71400
ctcacacaag cacaccagga ggtgctggag gggacggcag acccccatcc tcaccgcatc 71460
cgagaaggga cctagggggt ccaaactctt cagatgaagt cttatgctgg gatcctgggg 71520
tcagtgaagg cagggtcaga ggtcaggtgg gggcaggagc accgtctgat gagcacctct 71580
atgggcaggg accatgccgg gtgcccgggg aacggggggc aggccccatg ccaggtgccc 71640
aggggacagg ggtcagggcc cacatggagt gcccaaggca caggggccag ggcctgcccc 71700
gccctggaac tcctcgctga gctgggagag aagcacagga gcgatggaag gtccaccgag 71760
gctcagacca agtagggggt tgaggtccac agactctcgg ggcagagatg ctgaagccgg 71820
acagcagaca cgggggtgcc aggcaagggt gcatctgcat agcaccttca ggaagtgagc 71880
aggtactgtg ggggaggaga gagccggcag agcggcaggt ggaccggcct cccccactgc 71940
ccgcagacca cgtggtgtgt gaggaggagt gcaagtacgc catgctggcg ctgaactgca 72000
tctgcccggc gacctccacc ctcatcaccc tgctggtgca cacgtcccgc ggccagtgag 72060
tgccccgtgc cccgggggac cgacctccat ggcggggccg gcgcagggag acaacgcagg 72120
gcctgcttgg gggcggggat gggcttccca gaggaggggc acatggcggg caaaagtcct 72180
gcatagggag gggatccatg ccaggggaag cagagggggg cacctgcaga cccagccggg 72240
gagaaggggc agccatggcc gagggtgacg ctcccctggc cccgccctgg cccacaggga 72300
gggacaggag tctccggagc agtggcagcg catgtatggg cgctgctccg gcaacgaggt 72360
gtaccacatc cgcatgggtg acagcaagtt cttccgcgag tacgagggca agagcttcac 72420
ctacgcggcc ttccacgccc acaagaagta aggccgggct gcatccacag ggctggcgct 72480
ccagggctgc tctgctctgt gccctcccca ccctcccggt caggcacagg ggtggccctg 72540
gggcggggct gcagagggct cgggggaggg catcaggtca tcctgcctgg cgagggcagc 72600
cgcaggactg ggctccgggt ccacataaaa acctgccacg cggctcctcc ctgaggcttg 72660
tgggctgacc ccagctctct ggtccccaac acctctggga cgggagggct cagccaaggt 72720
ccctgacccc aaatggcccc caggaggaag acgcggagct ccggtgggga ctctggtgat 72780
ttgcaggaag ggcaggcagg gagcgggaca gggcgggtga gcggcggtac ctgaagttgc 72840
cggtgcctct gcccaggtat ggcgtgtgcc tcatcgggct gaagcgggag gacaacaaga 72900
gcatcctgct gaacccgggg ccccggcaca tcctggccgc ctctgacacc tgcttctaca 72960
tcaacatcac caaggaggag aactcggcct tcatcttcaa gcaggaggag aagcggaaga 73020
agagggcctt ctcggggcag gggctgcacg agggtccggc ccgcctgccc gtgcacagca 73080
tcatcgcctc catgggtgag ccgggacagg cgcgcgggac tccctgggcc tgctcctttg 73140
gcgggagacc aggcgggaca ccggcaggtg accaggtggg atgggagacc aggcaggaca 73200
gggggaggtg accaggtggg acaggagacc aggcaggaca ggggcaggtg accaggtggg 73260
acgggagacc aggcagggcg ggagaccagg tgggacagga gaccagaccg ggcagggcag 73320
gagaccaggc caatgtggcc cccagaccca gttcctcttg gcctatgcct ccaaccttgg 73380
acaggtggag tctctctggg cctgtttttg aatctgtcaa acaggtgtcc ccgccttcct 73440
gtggccacct ttgtgggcat tgctcactgt gtccaagtgc ctgtccaagt ggggccgccc 73500
acaggaccgg ttggcagctc aaccggaggc tcctggtggt cccatcagcc cggagggtct 73560
gcttcacgtg tgtccctcaa acagtcggga gtcctgacgt ccactggggc caggagttgg 73620
cggaatgagg tcgcagtggc cgagggcttt ggcctcttct cgtgccttca gggatcctcc 73680
cggggagccg cttaccagac agggtcaggc tgcctctgag caggtggagg cccatggccc 73740
ctagggcacc acccatagtg gtgttgcccc ctccccagcc aggccttcct gggggacagt 73800
tagggagcag ggccaggcca ggaagccact caggccacag acccacagcc gggccagcat 73860
gttgccacct ccgtacagtg gcccaggcag aggctgaccc tatggggcac cccagcacgc 73920
ccaccctggg gtgttgttac acggtggctg ctggggcacc aggtggttca gtgcagtggg 73980
gcacagtctc caagacccag agggccctgg ggtttggaga cgtgccgatg cggagcccac 74040
cacctgccag accccgcagg ttcccggccg ccgtctacgg cagctcactc ggggggccgg 74100
gcctggccgc agggcactgg ggaggcaggc tgctgctgcc tagccacacc tccaccttca 74160
cctgcgcagt aggcactctg cccccaggtg gcttccagga aaccagggtg actcgggcaa 74220
ccctcactgt acccacagag gccctgggcc atacctagag gtccacaacc cccatctggc 74280
agcctggggt ggtgcaggag tggcagagtc tgctcccaca ggcactgagt cacccagctg 74340
ctccccacct ggccccatcc accaggcagc ctgaccagct gcacaggccc ctaaggctga 74400
gacccccgag cccagaatca gccaaccccc tcctcaggca tctggtgctg aggccacagc 74460
agctggcctg ggtggcaccg atggggcact ggggccccct gggtcttcgc tcaacatcat 74520
cgccacccca gaggccactg tccctgttgt atggaggggg aaactgaggc atagattgaa 74580
gctcctcagc tggagcacag gagccaggcc atgacagggt ctccagagct gactgtgttc 74640
acctgagctc tgggaactcg ccgcccatgg agggtgggag tcgggctgtg gccaagcaca 74700
gggctctctt ccagggacag tggccatgga cctgcagggc acagagcacc ggcctacgca 74760
gagcggcggt gggggcgggg gcagcaagct ggcactgccc acggagaacg gctcgggcag 74820
ccggcggccc agcatcgcgc ccgtcctgga actggccgac agctcagccc tgctgccctg 74880
cgacctgctg agcgaccagt cggaggatga ggtgacgccg tcggacgacg aggggctctc 74940
cgtggtagag tgagtgctgc cttggagacg gctcccagtg gggggaggag ccgcccatga 75000
gtgcggggga tgggtgtcgg agcatccttg gtggtccccc atgctctgaa ttgcagcttc 75060
tggacagctc cgtggaagtc cttgtttgac aaatgaaatc ttcagggggc ccaacacaga 75120
catcagggcc acatcaccct cgtcgccggg gagcactttt gagtgtcact gagatggggt 75180
gtgctgggct acaccctttc cagttggggc tgggggtgca gagctaattg gagcgaggca 75240
gctcactggc acaggggctg tcaggcacca ggcagcgcca ccctcagaga ggggcccgtt 75300
cccacccacc tcaccagccc catagtggcc cggccactct ctgaatcagg atggagctgg 75360
gcagtgaccc caggccatcc tccacccagt gccctaggtc tcccccttag cactacagag 75420
cacagagggg cacagcccgc ctgaccaggg gtgggtgtcc tctgagcagg gtccctgtgc 75480
aacccctggg caaggcagtg tcccagcctg gaaaccacag cccgtcctga gttgttgtcc 75540
tggcctaggt ttggggccaa gtcctcctgc ttcaaatcat gagacaggag gccccactct 75600
gttctcagca gcttctgcct tttggcctca gccaggacag acaagtgccc cagctgcagg 75660
gcccgaggtc catcctcagc ggggctgcct cactctgtcc tggcctttgc ctctggggtg 75720
gggtcaacac actgtaatga cagcccagct gctgggaaac agccctgaac cattgcatgt 75780
gtgtgttggg tgctgctggg gacggggtgg tggcctgctg gggacaacag cctggctgga 75840
caagtatgtg ggtaagagcc caaggccaga gtgcctgccc caccagccgg gggtgctggg 75900
gatgtcaggg aggcatggcg ggcgggcaga gccctgtggg ttttgcatgt ggctgaaaag 75960
cctggtctag gctgtggtgg gaggagaaag accgagtagg gcatgggggt gggtgtgcaa 76020
ggggggtgtg tccggtgtgt gtgtgtggtg tatgttatgt gtgtggtgtg tgtccatatg 76080
tgtaatgtgt gttgtgtgtc aacgtgtgtt tgtcacgtgt ggtgtgtgtt gtgtgatatg 76140
tgatgtgtgt ctgggtgtgt gtggtatgtg tccgtgtgtg tgatgtgtgt ctgagtggta 76200
ttgtgtgtgg tatgtggtgt ctgtgtgttg tgtgtggtgt gtgtccgtgt gtggtgtgtg 76260
tggtgtctgt tgtgtgtgtg gtgtgttgtg tgtggtgtgt gtgtctgtgt gctgtgtgtt 76320
gtgtgtctgg gtgtgttgtg tgtccgtgtg tggtgcgtgt tgtgtctgtg tgtggtgtgt 76380
gttgcgtatg ttgtgtgtcc gtgtgtgtgt ggtgtgtgtc tgtgtgttgt gtggtgtgtc 76440
tgtggtgtgt ctgtgtgttg tgtgtccgtg tgtggtacgt gttgtgtctg tgtggtgtgt 76500
gttgcatatg ttgtgtgtct gtgtgtgctg tgtgtctgtg tagtgtgttg tgtggtctgt 76560
gtggtgtgtc tgtgtgttgt gtgtccatgt gtggtacgtg ttgtgtgttg tgtatgttgt 76620
gtgtcgatgt gtgtgttgtg tgtctgggtg tgtggtgtgt atgttatgtg tccgtgcacg 76680
tggtgcacgt gtgcatacgc ctgcatgtgt tcatttctgt gcgcatgtgt tgtgtgtgtg 76740
tccgggtgtg tccatttccg tgtgcctgta tggggccatg tgttatgccg agggctgacc 76800
atgggggggt cctgggctga ccaggtgagg ggtgagcccc accgccaccc ccttccacac 76860
ctgggtgagg gcagcagcag tgagggccct acccacccct cggtctcctc cagtccccca 76920
aggccctgat ggggctaagt ccatgcctcc ccagccctgg ccttgcagcc gctgctgacc 76980
cgccaggcag gcacgggtcc ttaaggttcg gcacctgcat gggtgccctg ggcactgccc 77040
tgactgccct gcaggacaca ctgggtcctg ggtgccaagg ctaggcaggc cctatgacac 77100
ggtgaccaca ggctcagctg gaggagcgtt tgctgatgca caggtggtta agggaagaac 77160
gggccacctt gggtcagctg tgcgtgaccc cgagcaacgt ggctgtgggt ggagtgggtg 77220
ccctcgagtc ccccagcccg aggggggccc cagagcagac ccagccacct ctgtgcagct 77280
gtgctgaggg ctcctgtctc ctgccccagg tatgtgaagg gctaccctcc caactcgccc 77340
tacatcggca gctccccaac cctgtgccac ctcctgcctg tgaaagcccc cttctgctgc 77400
ctgcggctgg acaaggtaag gctggcggct ctgccgcgct ctgcaccccc agacgccagc 77460
accgggccgt gcatacctgc cctggtttct ctttggtcac tttacatttc gataccattg 77520
caaacttcta gcacagctgc aagaattctg caagggagag ccacagatcc ttcacccaga 77580
ttcagcagac ggtcccttcc tgtcccgttt gggctctccc tctcacagtg tctatgttag 77640
aggcacctgt tttctgagcc atcttgagaa caggttggag ccaccacacc cctttcccct 77700
aatacatcta catgcgttcc caaagatcaa gaaccatctc gtaactacag ctcattagga 77760
cagggacccc ggcccggcat gggtgtctga tccacagtcc aagttcagat tgggccgagg 77820
gccccgaagg ccttcagcgt cctgcgtggc agtgttttcc ccaccgggag cctgtcccgg 77880
ctgcgtctta gcaactcctt tctcgttact ctcccttaat ctggaatgtt ccctggggtc 77940
tcttgacctt aatatttttg cagagcaggg accagtgacc tggtggcagg tgggtctgcg 78000
atgtttcttg gtggtgggac tctgcctgca tgtggggcca gccctccctg gaaactcggg 78060
ggtcaattgt caggtcactg gcgatgttta cttggatctc atggcaagct ggggtcagta 78120
gggtttcccc actgtgaaaa tgactgtttt ccttctggag ttagcagctt ctctgtgggg 78180
gacgtgttga gatcaggaaa gcaaaccact cgacccagcg gcttcaacat ccctcagtgg 78240
gttctttttt gtttatttgt tgtttggttt tttttaagac ggggtcccac tctgtcatcc 78300
aggctggagt gcagtggtgg gatcatagct cactacagcc tccacctccc aggctcaagg 78360
ggtcctccca cctcagcctc ccaagtggct gggaacacag gcacgcacca ccacacctgg 78420
ctaattttat ttatttattt attttttgta gtgatggggt ctcactatgt tgcccaggct 78480
agtctcgaac tcctggactc aagtgatcct cccacctcgg cctcccaaag tgctggggtt 78540
acaggcgtga gccaccatgc ctgccatctg tggatggttt ccagttccgg aatctctctc 78600
cagctgtgtg ttagggctcg gccacggagg ggacctcccc ttccccatgt gtgtgtgtcc 78660
ttcacggacc acaggctccc agcatattct gtgggttata atctgtggcc ggtcattgca 78720
gtagcatcat ccttgacaga tcgttattga ttctgatgct cggaccccct cagttcactg 78780
ggtggggtgg gggccttcaa gcggcttctg ggtgcttctg acacgatccc ctcacccttt 78840
gagctcatct gtgctttcca accggagatg ttccagccac atcttggcct tcgcctgctc 78900
cagtctggaa tgaaccactt ctccaaggaa ccctgattcc ttttagtgga aaatgatgat 78960
tggaaaccaa gacctgggca cgtggcgtgc tcactgctgt tggcatccct gctctgagaa 79020
aacgtgtgtg catacacatg acacgtatct atgcccacac ctagatctct agccacatgc 79080
caaaaccaca tgttcacatg gacaccgccc tttccacccc tgacatgact gctctgtgcc 79140
gcctgtgggt acagctgtgg catctggtgg tgcctgtagc tccccacagg cgtgtgcagg 79200
ccgtgaaagg gctgtgggcc gagaggctaa cggctgggtg ttcacggggg atgtttggtg 79260
aggggtctgg gagggctcca gtggccagca ggaaccacag ccctgactcc agccctgact 79320
ccagcatctg cccccagggc tgcaagcaca acagctatga agacgccaag gcctacgggt 79380
tcaagaacaa gctgatcatc gtctcggcag agacggccgg caatgggctg tacaacttca 79440
tcgtgccact gcgggcctac tacagatccc gcaaggagct gaaccccatc gtgctgctgc 79500
tggacaacaa gtgaggctcc tggggctcag cccaccccgc ccacccgggc cctcagacct 79560
gcagccagca gcctccccaa ctgggcccac ccttcgcctt tgcagagggc acgggaacat 79620
ggggcctctg gcctggtcct ctcagctttc ctaaaaaggg ggactctcct tcctgctccc 79680
aactcctcct gctcccagct cctccccaca cccactcctg ctcccagctc ctccccaccc 79740
ccagctcctc tggctcctgg gtcctccctg ctccctgttc ccccagttcc cagctccacc 79800
caactcccag ctcctccttg cttccagctc ccccagttcc cagctactct ccattcccag 79860
ctcctcccca ctcccagctt ctccccactc ccagttcccc ctcactccca gctcctccct 79920
gctcccagtt cctctggcca ccagctcctc cccactccca gttcctctgt ctcccagctc 79980
ctccatgctc tcagctcctg tggctcccag ctcctcccac tctggtcctc tctccccctt 80040
tccccctcct cccttgtcac tccttctgtc ctgtttgcct cctgctccac tcactctgag 80100
ccccaggatt ggggtggagg gataaatggc tcttcctcct gggcaccttt ttgcccaggg 80160
gaccctagga ccctgacagc tgagcccagg gtcatcttgg ctgtgtgacc tcagcaggtc 80220
ccaccctccc gggccttggt ttccccttga ataaaataaa gaatggccca ctggccttaa 80280
agtactcccc aggtcccata cgctgcggtt ctggggaacc cctgcctggc ccagctctgt 80340
gcatggaggg tagggcccca ctgggcctga ggagggcagg ccttgaagca gggtgggccc 80400
ctccaggacc gctgtcccca caggcccgac caccacttcc tggaagccat ctgctgcttc 80460
cccatggtct actacatgga gggctctgtg gacaagtaag gcgtggccgg ccgaggctcg 80520
tgggggctcc acacccaccc ctcccctcct cttccaaagt ctggggtgac cccgaccgca 80580
ggtggggtgg ggggctgagg tcctcctgcc ttctgaccaa atcccggggt cctgtgggtg 80640
gggagtgggc cgcatcctca gccacgggcc ctcggtcccg ccaccagcct ggacagcctg 80700
ctgcagtgtg gcatcatcta tgcggacaac ctggtggtgg tggacaagga gagcaccatg 80760
agcgccgagg aggactacat ggcggacgcc aagaccatcg tcaacgtgca gaccatgttc 80820
cggtgcgtcc agtgtccggg gctcggctct aaaccacccc acagccacga ccacgggccc 80880
tcgccctgag acccccacag ccacgaccac gggccctcgc cctgagaccc ccacagccac 80940
gaccacgggc cctcgccctg agaccgccac agccacgacc acgggccctc gccctgagac 81000
ccccacagct atgaccacaa gcccccaccc tgaaaccccc acaaccacag ccatgggacc 81060
acaccctgag acccccacag ccatggactc tgcccagaga cccccacagc cacgaccaca 81120
agccctccac cctgagagtc ccacagccat gaccatgggc ctctgccctg agacccccca 81180
cagccgtggg accctgccct gagaccccca tagccaagac agtgggccct gccctgagac 81240
ccccccacag ccatgggacc ccgccctgag acccccacag ccacatgatc atgggccccc 81300
accctgagac ctcctacaac caccatgggc cccgccctga gccgcctgcc tcccccaggc 81360
tcttccccag cctcagcatc accacggagc tcacccaccc ttccaacatg cgcttcatgc 81420
agttccgcgc caaggacagc tactctctgg ctctttccaa actagaaaag gtgagcagcc 81480
ctgccccgtg ccagctgcca ccccagaatc ccagaaagag tgggagaaag gggctcaggg 81540
gaaagggggc cagtgccatg ggaggctggg ctcctgccgc cctcctgctg gggaactcag 81600
gagatggcgt ggggggccca gcatggacag ggtgctcttg atggtggaac caggagatgg 81660
aggcagggcg tttccctgac cgcgtgtgag gcactgggaa tgtggcccat agcagccttc 81720
catctccctg agcagggacc aggcctggcc gtatctggag gccaaggcca tctgtcctgg 81780
catggtcagt tggtcagaac tcccgtgggg agccctcaga tcggtggttc cacataggtt 81840
ggccagtagc tcttagtaca gataacgcac acggctgcac cattccagac ttctccgctg 81900
ccctggccac tacgcccgac cttgaaacag gttcagtata accactgcct ccttgtattg 81960
acaagggacg gagggcctga gagggaaggg gcctgccccg gatcgcacag tggagcaagt 82020
ggctgagctg gaattggctt tctgcccttg gagctccatg aagggcacca cccagggtca 82080
ggtgtggaac ccaggggcac gggcactgtt gctgttgcct tgatatctgg ctgaccccag 82140
ccccaccgca ttccccacct gctcaagctg ggacagcacc accttgtcca cacgggggct 82200
ggtgcccagg cagccctagg ctgagagcag ggagcaggca ccttggtcag cagcaatgct 82260
gtctgctcta cacgaacccc gagctcaccg gtctgggctg aagtcctcat cggcgagctg 82320
ctgggacctg cgtggctgca ggattgtgac accgtggagg atctactgag ccaggcccgg 82380
cctggccacc aacaccaggc agaggacaca cacgggcact ccctgcgaca cggacatggc 82440
tttgtcccac ctgaacccga tggagagtga aagtgtgttc cggccagccg tggaccaaga 82500
gcccataggg atcctggagt cagttctgcc ccagagaagc gagaggaggc cgggctgggc 82560
agccaccagg tcaacagggg cttctgcctt agagatgcca gcctgaggcg tagggggatg 82620
ctcgggcacc tggtctcagc acaggagagg gctctgtctg ccctgcccgc cgcccaagcc 82680
caccctggag cctgccctgc ccagcgtcgg gagctcctgg ccccagtccc cggctcagcc 82740
ggcagagggg tgtgctctgc agctggaacc acggaagggg aggaagttca caggattctg 82800
tgttcgggtg ccgggccgct ccccagggct gggaggactc tccggatctg gaagaccaag 82860
tctgaccctg tgtggacagg gatgctgccg tggagtcggg gtcgaggcag tcatcctggc 82920
gcggctcctc cggcctcagc cttgcacctc tctgtcccac aaggtggctt gaagtttggg 82980
tcagcaagca cgcagccaac acgctcctgc ccgccttccc gccaggcagc catcgccaat 83040
cacccacgct ccgccccgcc gtggggccca tctctttccc cggcttcacc tccactgggg 83100
ctctgtgttg ccggggcggg tgcggccagc tctccatctc agagcagtga acagtcctgg 83160
gctccagctc cagtcatgcg attccgtggc agttgtgtga cagggaccaa ggagaaatca 83220
ggacatcggc aaagcctctg gaagcagccg tgagctcctc tgggctgaca tggtgctggg 83280
gtccatgtgg gacagatgcc ctgggccctg ggcagggcca ggcatataca gagacgtgga 83340
gccgagggag gagagggtgc cgtggaccac ctgacccatc accctctgca gaggctggga 83400
tccgcctccc cagcatgcaa ggagcctgta gaaggcacca ggggctgcgt cttctccagc 83460
ctgggtggcc ttggccccag atcccccatg ggtctctctg acgggccagc atacggtgac 83520
ctgcttccaa caaggacacc tgtggcagct tcagatcctt atttaaaaga cattaatgcc 83580
aatttattat aaaaatgtac atgtttagta tgtattttac ttcaaagaat actgaaagta 83640
aaaaaaaaaa aaaattgaag aaaagttacc ccaaatccct gcagccaaca tcttctacat 83700
ccaggcccag tggaaggata aagacaggat tccaggcacg actccggaag gaaaaaggga 83760
ggaggtggag atggcataca cgaccgtcag tgagatgctc tgccaggtgc agcggctcat 83820
gcctgtaatc ccagcacttt tagaggctga agcaggaaga tcgcttgagg ccagaagttc 83880
gagaccagcc caggcaacat agcaagtccc catctataca aaaaatttaa tggctggggg 83940
cggtggctca tgcctgtaat cccagcactt tgggaggcta aggcggacgg atcacctgag 84000
gtcaggagtt cgagaccagg ctggccaaca tggagaaacc tctctactaa agacacaaaa 84060
attagccggg cgtggtggct gtaaccccag ctacttggga ggctagggca ggagaattgt 84120
ttgaacccgg gatgcagagg ttgcagtgag ccgagattgt gccactgcac tccaggctgg 84180
gcgacagagc gagaccctgt ctcaaaaaaa accaagcaaa aaaatgaaac tattattaag 84240
gatgctgctg gtggggtgac atgcatctcc ccttgagggc tggctccaga aggctctcag 84300
agccccggtg tgtgagagga gtctctcccc tgaggcccac ctcccctgcc gtccacctcc 84360
cctggtctcc agcacccagg actcctccac cacttcattg ctttcacatg gtcagcctgt 84420
gtgatctctc ctcctcacca ggagccttcc ttcaggctgg ctctgcccat cctggggctg 84480
cacggtgcct gtcctgctcc ctctgaccgg gggtctcgtg ctcaggaagg gctcatccgc 84540
tcctgtgtgc tcctgtcttc actgtcactt gtgaatggca cccgctcagc ccctgctgaa 84600
gccctcctgt ccagaaagca ggaggaaatc tctggaaggt cctgaaacgt ccagcttttt 84660
ctttccttcc acgtctctct ctggccctgt cgtggttctt gtttcctgtt tagcgttgtt 84720
ctgagtaaag gaaaattaaa attgcaagtt gttctggaat ttcacgttcg tctccgcgaa 84780
gtacggctgg aattctggat gcaaatcacc acgattgcaa actcacacgc ccatcgcagc 84840
tcatcgcacc tggttcttgc cccaagagcg gaaacgccgc acgaaactaa ttccactgtt 84900
tctcacgccc cagccttccc accggccact gatgagtaag ggcgaacccg gaggaaaagg 84960
ggcttctgcc tgcttgtcct gtcgctgtcg tgtcttttac ctgtgaatcg agttctggtt 85020
ccggggggaa gtgtggcctc cgtgggcgca cacgcctgcc tgtgcacact tgcttggagg 85080
ccgagctcca gggttggggc cctccgctga agaatgaccc gagagttggc cacggccggg 85140
tccggagccc gtggatgtac cgcctcacgt gacagaaggg cctctgcaga tgggattaag 85200
tcacgggcct cgagatggga gatcctcctg gagcatccgg caggttcacg ccgtcagggt 85260
ccttctaggg agaggccaga ggtccccatc cggtgggaag aagctgcacg gccagctcag 85320
aagagggaag agggagccac aagccaaggc aggtggcctc caggagctgg aaaaggcaag 85380
agaaggaggc ccccaggcct ccagagggag cggggccctg cccaggcctg gatccagcct 85440
gagacacctc aaactcccga ctccagaaac gggagagagg agacaggtgt cgttttagct 85500
gctaagtttg cggtcatttg ttacgggagc cccaggaaac tcagtgggtc cattgcaagc 85560
ctggagcaca gggacgggga ggccaaggac agcagggagc ccgatgcttg ctcctcctca 85620
gcccagactc cacacgccct ccggcaccac ttacaaaaca ccgggggagg agaggattat 85680
caggaggatt tggaatttcg ggatggcaag agcagggcgc ttgaccaagc gcagtgccca 85740
tggcagccgc cgggagtcca ccttctcatc agagccccac atcactcctc ccgggctctg 85800
gccctgagtg tgtctgggaa gatagagctg gttcaggcct gccggtgtat gcacacatgc 85860
agacacacac tgtgtacacg tggacacaca caccatgcac aaatgtgcac acaggtatca 85920
tgcacacatg tacggtgcac acacagtgcc ctcgaccccg tggctgccgt gccactggag 85980
ggacctcggc accagcccat ctgaggcccc tcctttccca cagagggagc gagagaatgg 86040
ctccaacctg gccttcatgt tccgcctgcc gttcgccgcc ggccgcgtct tcagcatcag 86100
catgttggac acactgctct accaggtcag cggggaagcg gcagcaggag ggtggcgcct 86160
gggtgggacc cccgtcatgc cctcagctct tcagcctggt ccctgttctg aatgatagga 86220
ctccctctga atgaccttcc ctggattcca aggagacctc tgggccctgt ccttgcccca 86280
gggatttctg ggcccttttt gacctatggg tgcctggcaa gggagttttc ttagaaaagg 86340
cctcccagaa ctctgcctgt gggtcatgtg gtgcttgggg acctggtggt tctgtgtgtg 86400
tgtatgcatg aggggtggcg agcccgtggc cggtggggta tggacctgtg tcccacgccc 86460
gtgcccgcgt gcctcactgt ggctccctcc ctccctccct ccctccctcc ctccctccct 86520
ccctccctgg ccagtccttc gtgaaggact acatgatcac catcacccgg ctgctgctgg 86580
gcctggacac cacgccgggc tcggggtacc tctgtgccgt aagtgcccct ggctgcgctg 86640
ggctgggggc gtgctgggct gtccaagtgg gtggatgggc acctgcccct gattcacggt 86700
ggccaggagg ctctgggtgc tgccacctgc cccagccaac tcagggttcc caccctgcag 86760
atgaaaatca ccgagggcga cctgtggatc cgcacgtacg gccgcctctt ccagaagctc 86820
tgctcctcca gcgccgagat ccccattggc atctaccgga cagagagcca cgtcttctcc 86880
acctcggagg ttctggggca gcctgggggc tgggactgtg gcagcccctg tcctgtgtga 86940
cccacagcat ccccaccttc cgggggctgg gactgtggca gcccctgtcc tgtgtgaccc 87000
acagcatccc caccttcagt gtcagggacc tgggctagat cagctttgct attgctggca 87060
gctccttccg tctggtccgt gtgcccacgt gtagcgcttc cagctggagc agccatgacc 87120
cctaccgggg gcagagaggc tcaggggagt cttcaggaag aatacgggca gcccctgtgc 87180
tgcagtccac acagcagcag gcaccgtgcc caccagccct aagcatgttc cgtgcagacc 87240
ccaggctgag gcggcgtggg gggcaggggt gcgcccacag gtcccagact gcgcctgttt 87300
cctttgcagc cccacgacct cagagcccag gtaagcaacc cctccgtgcc cacgcagctt 87360
ctgcggagca ccagaacatc gcagcttcac atggagaagc ctgccaggcc ccacccaccc 87420
acccacccac agggccctgg gaaagccgag gcaggagcgg gtcccacgga tgtgtcggcc 87480
ccagcacggc tcagagaagg ctgttgacac tcactccctc ctgcactggt ggtggggaag 87540
ctgaggcctg gggggagtag cctgtgagtt tggacaccag gtgcaccccc gccccctccc 87600
aggccccacc aaggcaggca gcccccatgc ccatctggcc tgaccagccc ccagcctccc 87660
aggcctttct gaaggtgcca cccaggtggg atgcctacct cttcccagca ccccacgacc 87720
cacaggctct ggcaccccac gttccccagg ttcggggcct ccaaagggtg tgtttgcaag 87780
agggatcagg gctcatctgc agatggagaa attgacacgc agagggggtg acctctcagg 87840
gcaaggccag gatgtgctgg ggtccagatg ggtcccaggc cggacccaca gaaataaggg 87900
ctcagagagg cgaagggagc tgccctcagc agcctggcga atcccttgac caggcccggg 87960
cagggtgggt ggcccggcga tctgtgctca ggaggaaacc aggcacattc tttccagagg 88020
aggaaggcac atgcaccctg gggtctgtcg tcgtcctctt ccctaacacc cccagctgct 88080
cccacgcagg ccccaagctg cagagcccac acctcttcct aagcccctgc cccaaagccc 88140
gcgaccctcc cggcagcctc acccctcccc gccctgccct gccctgccct gcccagtccc 88200
agatctcggt gaacgtggag gactgtgagg acacacggga agtgaagggg ccctggggct 88260
cccgcgctgg caccggaggc agctcccagg gccgccacac gggcggcggt gaccccgcag 88320
agcacccact gctacggcgc aagagcctgc agtgggcccg gaggctgagc cgcaaggcgc 88380
ccaagcaggc aggccgggcg gcggccgcgg agtggatcag ccagcagcgc ctcagcctgt 88440
accggcgctc tgagcgccag gagctctccg agctggtgaa gaaccgcatg aagcacctgg 88500
ggctgcccac caccggctac ggtaagggca cacggcgcgg gtgggggccg gacggacgga 88560
ctgggccagg gtcgggccac agccaagaac agtcggccac ggcgtcccgg ggcccgggcc 88620
gtcctcctgt ctgtcatctg tctgtctgtc agcctttctg gccaccctct gcctgcctct 88680
actgtggggc cagctgtggg caccaccacg gcccagcaga ggccccgtgc agaggaggga 88740
agtggccatg gcccaccctg gtgctgggag gccacaggac ccttgggcat ccctggtgtg 88800
agccccgtag ggaggtgctc gcttccactg ctctggggcc tcagtttccc tctctgccaa 88860
attagagaca ggagctggct gagccctttg gccaggggag gcagctgtgg ggtggagagg 88920
gccaggctgg gctccccaag tcgagggcat cagctagagt tgggccagcc agctgcagcc 88980
aggcctgctg gacagcggat acccagggtc cctgagttct cgcagagaac aagactggtg 89040
gggaccccct cccagagccc ccagccctcc cagcagccag ggtagggggg agactttggg 89100
ggaacagttg ggggaaaggc ccatgccagg acatgcctct gtccaccatg ggcctgttgc 89160
cactcccacg gcacagcccc ctcctgccgc ttcagggagc ccggcgtccg tcttcagcaa 89220
cagatccgtg cagccccctc tctctgcgcc ttgtggtggg aagtgtgctt gggcttcggg 89280
gccctacatg ccctgcctgg cgtggagaga agctcatccc ctccctcact ctagagatgc 89340
tacctccgtt gatgaagcca tgggccccag ctccccagca ccgggccgct acccagtgac 89400
acccacccct gagccgggtc gaggctccac cttccctttg ttccatctca gggacttgcc 89460
tgatgctcag ggctgcctct gtcccgtcgg agtgccccgt ctcccaaccc tgcttcctgc 89520
gtctgtcacc tgggtcgggg tcttgagtcc cctgagcaga gtcaggagct cacggctggc 89580
ccaggagctg ctcacgggtg actgggctgg gctggcctgc gggcccgaag gagactcaga 89640
ggccagggtt tggggaacag gtggcctgtg aagacctttc ccggccccca gccctgtggg 89700
cgctggggaa ggtgtccccc tgtccccgcc ttgaagcttc cctccatccc cacagtgtcc 89760
ctgtcccggg agggacttca cgccctttca ggtggggctc acgaggctga ggggggtgcc 89820
cagcattcat gtttgtggtc ccctgtgact gctggcagag gatgatcccg cccggtctgg 89880
ccacccccag agctggtgcc tgcctctgcg accgctgcct gcccccagag cttggcaagg 89940
aaggagcaac tgcctttctg gtgaccgact cgcttctggt ggccggcctc ccgtgcagct 90000
gcccctgcac ccgcccactg tgccggccgc ccgcacctcg cttgctgata ttctctctct 90060
ctctctttct gtctgtgcct ctttctgtgt gttctgtaga ggacgtagca aatttaacag 90120
ccagtgatgt catgaatcgg gtaaacctgg gatatttgca aggtaattct gccctggcgg 90180
gtgccgacca ccgcacaacg gggctcgcca acccttcacc gccggcagcc ttgctgcgcc 90240
atcccggcca ggcaggtgga caggagctgt gagagcacgt cccaggtgtc agcccaggcg 90300
gccctgttgg gcaaggcctc gcatgccgac agagtgtccc ctggctgggc gttgaggacg 90360
ggcctgaggc tgaggtctgg ggcttgtgct agtcaaggtg ctgttggccg ccaggcagag 90420
tggcgactgc ccagctctcg ggctcaccct ggtgctgctt ctcctgcttt gctgtttacg 90480
atgagctctg atgtgaccgg tgggccaccc tggcctacag ccagcccttc cctgtggccg 90540
gccccacaag cagtctgagg accctaagct cctctgctct caggaagcac ccagagggtc 90600
ccgagccagg gccccgggag gagctcggtg aagcctgggc tggatgcagg ggtggggact 90660
ccaagccacg aggagtaggc aggctttatg gctgcccagg ccaggtggat ggtgaccttc 90720
gtcccccagc tggggctcca cgaggggatt cttcctgctc ggctcgagca gagccgctcc 90780
acaccccgtt tcctccaaga acatgctgtg ccccgtcagt gctcagcaga gtccgggcca 90840
gggtgctccc aggggtcctg gcagcctcag gggagctcag agcctgcccc cgctgccaca 90900
cctccctaca gggtaaccca ggagcttgaa gggcctcctg agccaggacg ggtgttagct 90960
cgggagggac ctgtttgcca caatgccctt gcacccggag gcagggccag gcctggggca 91020
gccacagaag taaagcgtcg gcctctcccg gctctgtgct tttccccacg atggcgctca 91080
tggaagaccc tcgctctgcc gggcactgtg gtgctcggac ctgcagctag cggccttcat 91140
gagtgggatg cctgcgtcgc ccgctcccct cacccgccaa agcttcctgc ggctcccact 91200
gcagctccag ggcaggcatg gccacagcgg gcttgggggg cgagggctca caggactccc 91260
gcggcaggca tttcctgggc tcggcctaca tgcccgggag ggtgacggtg ccggggttct 91320
ggggctgggg agctgcaccc ccatgtttag attcaagcgg agcctaggcc aagaggcaga 91380
acaggaagag tcacaccctt tgcggggagg gcgggcagca tcctggggcc cctccagcgt 91440
gcagccccca tcccacacac acagcgggag gaggcacccc agccccgata ctcacacaaa 91500
tcccctcttc acgccttcct cacagctgcc gtggggggag gcactagtta tccccagttt 91560
atagagaagg aaactgaggc tcgggtggcg gtagctctgg cctggcgtgg gggattcagg 91620
cgggagtgac cgtggatgcc aagagccagg aggtctggaa gcctctgggg cctgcagggt 91680
taggaagcgg gttggggggc gagcagagct accactgagg cctggagtaa aggtcggagg 91740
gtctgggtgg aggagtcagg tagccctggg gaccaggggc gaggtggccc tgccccagga 91800
catgcaccag aagagccaaa gccagcccct gccccacccc aggccctcag gcacacctgc 91860
tgccagcctt caccaagcac cgtggacacg cgaagctagt cctctgcgac catcctgggc 91920
agccaggacc agtgccatgt gactgaccac aacccaggcc ctggcactgc agctggggcc 91980
tggcatcccc acccgccccc tagcccagcc ccaagaaaca caaagcccag cctggctcag 92040
cccagtgagc tctgcttact tcagaagcgt gtggtccggg caccccagcg ggagaagctg 92100
gggcctgggg gccagtctgt gcctgccgga gtgaaatgag ctggtggccc cttgttctcg 92160
gtgtcccact gggtgctcgt cacaaagcca gtcaggcagg ggggcagggt cccaagaacc 92220
tactagagct gccctcacca cccactccct gtgccacctg ccatgcggcc accccagaag 92280
cgtgtgtggg cacgagggtg gggagggtgt gtctccctgc acagcctcag catgaggccc 92340
ctgggcctcc tccaaaggcc tggggaagac cccaccatgg gttttgggaa aagagcaaaa 92400
cagctgtgag gggcaggtgt caggccgtcc catcccgcag gtgtggacac aggagctggc 92460
accaaatgac ctgccgccgt gtgcgaaagg cctgaagcag agctggtctc ctggccggag 92520
ctgccctggt cgcccccaag tcctagcctg tgcccccgcc accctggcag cagctgtgct 92580
cacactgtgg gaactccaaa gcccccactg cagagggacc agcatggccc ccacctggct 92640
ggccagcagc ctccccgact tttcccttct cagggaccag ggcagggcta ccccaagggg 92700
agaggacggg cagagaggag ggaatggcag cagccagggt ggaggctccc tggggtcccc 92760
cgtcctgggt cacctttgtt ctctgtcctt ggagtcctgg aacaggaatc caggagcttc 92820
ccgtagacac catcagatgg ataaactgag gccacagacc ctttccagcc agtgaaccca 92880
gggccactgc tgggatggtg gcctctccct ccctgtgctt ggcagggcta ccctgccggc 92940
cccatggaga ctgtgagatg atgggggggc tgtctctcca ggaccgttct caccctgtgg 93000
gacacatgcc cacgcccacc ccatgagccg gacgccaggc tgtctcccat gaggggcaga 93060
ggccatgttc tcggagggat gagctgcggg gtgggggtgc tctgggctga tgccactcag 93120
gacttcagtc tgaagcaaag ggctgagcac agcgagtggg aatggcctgt ccaggcccgg 93180
ggacagcggc agctgcaggg ccctgaggga gggacagggc tgagcagcct ctggaggcgg 93240
gggtgggggt gtgtggatgt ggaggacggc atgcaggtgt gtatatgagt gagtgtgcag 93300
gggtctgtgg ataccatagg catgggttgc tatgaagatc tgtgcagaca cacaaatgtg 93360
tgtggaatac agaggtgaat ctgcaggtgt gtgcaggtgt agatgaaggc atgcatgcat 93420
gtgaggtgaa cagacacgtc ccggtgtctg caggctgacg tacgtggcag gtgtgcgctg 93480
gtgtgtgcag gtgtgctcag tgcctctgct cagggccacc cctttgctgc gatgccacct 93540
agcaccagag gtgggtgcgg gtcagagctg gctcccagct gccctcctgg ctgtcccctg 93600
ccctgtgtgg agatgggaca ggtgtcggtc agggatgggc cctggctggg ctcaccagga 93660
tgaggtgctg gagcagaatg gtcaggaagg ccggaaagac tcagctcatc ctggagcccc 93720
cacacctctg ggcccctgca gagctgggag gggcagggct gggggggtga cgtctgcccg 93780
gctgtgtcct ttgcagacga gatgaacgac caccagaaca ccctctccta cgtcctcatc 93840
aaccctccgc ccgacacgag gctggagccc agtgacattg tgtgagtagc acctgtgggc 93900
tgtgtggaga ccccccctga gcaccaggtg ggcactgggg agatgaggcc acaggcacca 93960
cagtggggcc gctcagcaga gggctgagca ggggctgccc ggcccacatc cactccaggg 94020
tcctctgtgc cctcccgcag ctatctcatc cgctccgacc ccctggctca cgtggccagc 94080
agctcccaga gccggaagag cagctgcagc cacaagctgt cgtcctgcaa ccccgagact 94140
cgcgacgaga cacagctctg agccagccct gcacggagct caggccacca agcccggggt 94200
cctcaggaag gacgtggagg agcgtgtgag gacacggtgg cactagcgtg accctgggga 94260
tggcacactc tactcaccat ggctcctggg actccaccct ggaaaggagc ccctcatgcg 94320
gggggagggc cagctcaccc ctgggcacct gcaggctagt gaggagagtt ttttaaccta 94380
tttttacacg tcgatgcagt ccacttctct ttacacagat gtaccgcaac tcgtgaccag 94440
ggctggctgg gagggcaacg cagggactgg acgccctaca gggccgagcc caggctgtgc 94500
tggagggtgg ggctggggtg catggggagg ggagcagaac ccagaaccca ggagccccgc 94560
gtgggccaca cccaactcag agccggcctg agcgttcacg gccaggcagc ctcgcttcct 94620
tgcagccaag ggctgggggc cagggctgct gttctgcact ctggggtggg tgagggggac 94680
cctgggctgt ttgctgtccc aagccccttc tggaagttag aagcagcaaa gggcccgggg 94740
aagccgggca tgtgagaggg gtgcgtcccc aggtccccca gagggccctg tcgccgagga 94800
cctttctgaa ggaagcagaa gacgccattt cctctacttc acactgaact gtcccagcca 94860
ctgcatctag ggggcattgg gcggaagatg gtgcatttcc atggaccatt ttacacttac 94920
cttttaaagc aaagcctcat tttctaaacc cctgacttgt gaagcacaat tcagcctccg 94980
ggctgggcca cgtggagaga gaggatcttc tcagcaaggc gagatcccgg gcggcggctg 95040
acatcaggag cgccaccctg cgtcctttgc tgctggttcc ttactggttt gtacggtcag 95100
cgctggaaac ttctattaaa tggatgcatt ctggaggcat gaagttacaa gtcaagtcgc 95160
cctgctcgtg tttccaaggc tctcacccct cccagccacc ccactttaag ggttacaaac 95220
acctgctggg gtccccaccc caaccccata ggcaagcccc cattccccag ccaggccagg 95280
acagtccttc caaaactcgg gaaccaaatt gtatttggct actggtgact ggatcctggt 95340
agccaggaaa cctgcctggt ggtgggggtc ccagagtcca ggagggctgt ctggtgagct 95400
gcccatcagc ctcacccctg cagccaggca tgtccctggg gtgggcacag agaccccagg 95460
ctctgcccgc agtggcacag aactcatctg aggccagtgg ctgctgggga tcccctacac 95520
tgggggtcag ggctgcccca ggtggggatg tgtgtgcacc tcaccacgtt cacttcaggg 95580
taccccaaga ggctgaaggg gaaggaccaa aaggccgagg tgcagcccct ccccggtgtc 95640
agggcagaca acacagcagc tgctggaggg gccggccctg gccacacaga ctagctagtc 95700
ccttactccc ggcctgtctg gaaccctcct gctcagaagg tgcccactag ccctctgtgg 95760
gggacagagc cagacatggg tggtcaggga gaggctgtgt ggattcaggg gaccagaaag 95820
taagtcccag gaccttgatg gagcggcagg gattgatgtt gggctagggt ggccagagcc 95880
tgtcccagca gggctggggt ctatcacgtt cctgggatcc aagcagcgag cacgccctgc 95940
cccgcagtca ccccgccccg cagtcgccct gcagctggaa ggcccaagtc tgcctcacct 96000
gggtggcctc tcatgtcccc cacaccctgg cccccaggcg aggggggctg cacagcacct 96060
gcagggagga gaagggagag aaaagccggt ctggctgctg ggatgggagg gccacagttc 96120
cagcagtggc aggggaagct gtagcccctg gagccccaca ctggaagagc tggcctgcag 96180
gaggcaccat gggggagtcg catgacttat tcgggattga cttgcgatgt ggatggtgtt 96240
cccggagtcc cctgtggcca ctccaccacc atgaggccgg gaggcatctt agcctttgag 96300
cctctctcca ggggtgagcg gagcccccca aagagggctg aaggcttgct gcccaagagg 96360
ggctgggtga gcacttgggg cctctgagaa catcagtggt ccgttccctc ctgcacactg 96420
gtggcaagtg gcagcatttt ttcataatct ccagtaatga ggccacttcg ggtccagccc 96480
tggacatccg aggaggaggc gggcagtccc tgccccttca ctaaccgcag aggatgccag 96540
ctctaggccc cctgctccgc ctggagctca tgcgggcagc cgtggacaca ggtggcaccc 96600
agcgcccagc ggcctgtgaa tcctcccgtg ggcaaagctg ggagccaggg gctggaacca 96660
ggcaggtcag tgactgtgag atgccagctg ccagcccaag aaaagctgcc tgcagcatct 96720
ggaaacttct gtgctctcct tggcctctgt gttcttcatc tccaggttta gggagcaccc 96780
gggtgcctct ctgcttgtcc cgagcccact caccaacagc cccagcttgc acagtcatga 96840
catcaggaag gtgggtccct gctcccagcc gtcctcgtcc accatcactt ctcccagcct 96900
cgtgtcctgc tgacccataa aaggtccccc tgcaaagtac accaagtgaa gtaggatctg 96960
agcaaaggtt gagggactga attccctaag aagtcatcac tgcctagaat aagcgaaaag 97020
aatttttttt aatgttttac ggtagaatta tttgaaacat acaaaatgag tgagacacct 97080
gctattttcc ttattcctgt tttttgtttg tttttatttt ccttatacct aattcatcta 97140
acagaaaact gggcagggcg cagtgtctca cacctgtaat cccagcactt tgggaggcca 97200
aggcaggtgg actgcttgag cccaggagtt gagtttaaga tcagcgtggg caacatgatg 97260
aaccctgact gtatcaaaaa gtacaaaaaa aaaaatagct agacgtggtg gcatgtgcat 97320
acagtcccag gtacccaaga ggctgaggaa ggaggatcac ctgagctggg gaggttgagg 97380
ctgccgtgag ctgagatggc accactgcac tccagcctgg gtggcagaga gagaccctgt 97440
ctcaaacaaa acaaacaaac aaaaaagaaa aagaaaataa aactgtttgc tcaaaatcag 97500
aataccaaca gtgtattggg tgattatcgc ttatgtgtga gtgaaatgta agagcaacgt 97560
taaaagggac aggtgggagg aagcgggggc catcagttac aagttaccat gtgacctgag 97620
aagcagtaca gtgtaactta caggtggatc tggatgagct gcaaactcta gggcaaccac 97680
taaaatatat atatacttat ttttcttttt attatttttt tctatatatg gaagtataat 97740
tgatacgcta caaaagacaa gactatggaa tcatataaaa tgcttaactg aaaccagaga 97800
aagcagaaaa gaaaggcaga tagaaactaa gaccaagggc aacaaataga aaacagttac 97860
aaatatggta gatgataatc ccacgaaccc agtcatcaca ttcaatgtac atgaattagt 97920
ctaaatacac caattaaaat acagagactg gccgggcgcg gtggctcaca cctctaatcc 97980
cagcactctg ggaggccgag 98000
<210> 3
<211> 7123
<212> DNA
<213> Homo sapiens
<400> 3
agggcaacgc gagggaagaa ggtggcggct cccactcgct tctccctcgg gtcgggtccg 60
agctgccagg ccgcatgcca ctccctgacg gggcgcggac cccggggggc gtctgccggg 120
aggcgcgcgg cgggggctac accaaccgga ccttcgagtt tgacgacggc caatgcgccc 180
ccaggcggcc ctgcgcgggg gacggcgcgc tcctggacac cgccggcttc aagatgagcg 240
acctggactc cgaggtgctg cccttgccgc cgcgctaccg cttccgggac ctgctgctgg 300
gcgacccgtc cttccagaac gacgacaggg tccaggtgga gttctacgtc aacgagaaca 360
ccttcaagga gcggctcaag ctgttcttca tcaaaaacca aagatcgagc ctgaggatcc 420
ggctgttcaa cttctccctg aagctgctca cctgcctgct ctacattgtg cgcgtcctgc 480
tcgatgaccc ggccctgggc atcggatgct ggggctgccc aaagcagaac tactccttca 540
atgactcgtc ctccgagatc aactgggctc ctattctgtg ggtggagaga aagatgacac 600
tgtgggcgat ccaggtcatc gtggccataa taagcttcct ggagacgatg cttctcatct 660
acctcagcta caaaggcaac atctgggagc agatcttccg cgtgtccttc gtcctggaga 720
tgatcaacac tctgcccttc atcatcacga tcttctggcc gccgctgcgg aacctgttca 780
tccccgtctt tctgaactgc tggctggcca agcacgcgct ggaaaacatg attaatgact 840
tccaccgtgc catcctgcgg acacagtcag ccatgttcaa ccaggtcctc atcctcttct 900
gcaccctgct gtgcctcgtt ttcacgggga cctgcggcat ccagcacctg gagcgggcgg 960
gcgagaacct gtccctcctg acctccttct acttctgcat cgtcaccttc tccaccgtgg 1020
gctacggtga cgtcacgccc aagatctggc catcgcagct gctggtggtc atcatgatct 1080
gcgtggccct cgtggtgctc ccactgcagt tcgaggagct cgtctacctc tggatggagc 1140
ggcagaagtc agggggcaac tacagccgcc accgtgcgca gacggagaag cacgtggtcc 1200
tgtgtgtcag ctccctcaag atcgaccttc tcatggactt cctgaacgag ttctacgccc 1260
acccccggct ccaggactat tacgtggtca tcctgtgccc cacggagatg gatgtccagg 1320
tgcgcagagt cctgcagatc cctctgtggt cccagcgggt catctacctc cagggctctg 1380
cactcaaaga ccaggacctc atgcgagcca agatggacaa tggggaggcc tgcttcatcc 1440
tcagcagcag gaacgaggtg gaccgcacgg ctgcagacca ccagaccatc ctgcgcgcct 1500
gggccgtgaa ggacttcgcc cccaactgcc ccctctacgt ccagatcctc aaacctgaaa 1560
acaagtttca cgtcaagttt gctgaccacg tggtgtgtga ggaggagtgc aagtacgcca 1620
tgctggcgct gaactgcatc tgcccggcga cctccaccct catcaccctg ctggtgcaca 1680
cgtcccgcgg ccaggaggga caggagtctc cggagcagtg gcagcgcatg tatgggcgct 1740
gctccggcaa cgaggtgtac cacatccgca tgggtgacag caagttcttc cgcgagtacg 1800
agggcaagag cttcacctac gcggccttcc acgcccacaa gaagtatggc gtgtgcctca 1860
tcgggctgaa gcgggaggac aacaagagca tcctgctgaa cccggggccc cggcacatcc 1920
tggccgcctc tgacacctgc ttctacatca acatcaccaa ggaggagaac tcggccttca 1980
tcttcaagca ggaggagaag cggaagaaga gggccttctc ggggcagggg ctgcacgagg 2040
gtccggcccg cctgcccgtg cacagcatca tcgcctccat ggggacagtg gccatggacc 2100
tgcagggcac agagcaccgg cctacgcaga gcggcggtgg gggcgggggc agcaagctgg 2160
cactgcccac ggagaacggc tcgggcagcc ggcggcccag catcgcgccc gtcctggaac 2220
tggccgacag ctcagccctg ctgccctgcg acctgctgag cgaccagtcg gaggatgagg 2280
tgacgccgtc ggacgacgag gggctctccg tggtagagta tgtgaagggc taccctccca 2340
actcgcccta catcggcagc tccccaaccc tgtgccacct cctgcctgtg aaagccccct 2400
tctgctgcct gcggctggac aagggctgca agcacaacag ctatgaagac gccaaggcct 2460
acgggttcaa gaacaagctg atcatcgtct cggcagagac ggccggcaat gggctgtaca 2520
acttcatcgt gccactgcgg gcctactaca gatcccgcaa ggagctgaac cccatcgtgc 2580
tgctgctgga caacaagccc gaccaccact tcctggaagc catctgctgc ttccccatgg 2640
tctactacat ggagggctct gtggacaacc tggacagcct gctgcagtgt ggcatcatct 2700
atgcggacaa cctggtggtg gtggacaagg agagcaccat gagcgccgag gaggactaca 2760
tggcggacgc caagaccatc gtcaacgtgc agaccatgtt ccggctcttc cccagcctca 2820
gcatcaccac ggagctcacc cacccttcca acatgcgctt catgcagttc cgcgccaagg 2880
acagctactc tctggctctt tccaaactag aaaagaggga gcgagagaat ggctccaacc 2940
tggccttcat gttccgcctg ccgttcgccg ccggccgcgt cttcagcatc agcatgttgg 3000
acacactgct ctaccagtcc ttcgtgaagg actacatgat caccatcacc cggctgctgc 3060
tgggcctgga caccacgccg ggctcggggt acctctgtgc catgaaaatc accgagggcg 3120
acctgtggat ccgcacgtac ggccgcctct tccagaagct ctgctcctcc agcgccgaga 3180
tccccattgg catctaccgg acagagagcc acgtcttctc cacctcggag ccccacgacc 3240
tcagagccca gtcccagatc tcggtgaacg tggaggactg tgaggacaca cgggaagtga 3300
aggggccctg gggctcccgc gctggcaccg gaggcagctc ccagggccgc cacacgggcg 3360
gcggtgaccc cgcagagcac ccactgctac ggcgcaagag cctgcagtgg gcccggaggc 3420
tgagccgcaa ggcgcccaag caggcaggcc gggcggcggc cgcggagtgg atcagccagc 3480
agcgcctcag cctgtaccgg cgctctgagc gccaggagct ctccgagctg gtgaagaacc 3540
gcatgaagca cctggggctg cccaccaccg gctacgacga gatgaacgac caccagaaca 3600
ccctctccta cgtcctcatc aaccctccgc ccgacacgag gctggagccc agtgacattg 3660
tctatctcat ccgctccgac cccctggctc acgtggccag cagctcccag agccggaaga 3720
gcagctgcag ccacaagctg tcgtcctgca accccgagac tcgcgacgag acacagctct 3780
gagccagccc tgcacggagc tcaggccacc aagcccgggg tcctcaggaa ggacgtggag 3840
gagcgtgtga ggacacggtg gcactagcgt gaccctgggg atggcacact ctactcacca 3900
tggctcctgg gactccaccc tggaaaggag cccctcatgc ggggggaggg ccagctcacc 3960
cctgggcacc tgcaggctag tgaggagagt tttttaacct atttttacac gtcgatgcag 4020
tccacttctc tttacacaga tgtaccgcaa ctcgtgacca gggctggctg ggagggcaac 4080
gcagggactg gacgccctac agggccgagc ccaggctgtg ctggagggtg gggctggggt 4140
gcatggggag gggagcagaa cccagaaccc aggagccccg cgtgggccac acccaactca 4200
gagccggcct gagcgttcac ggccaggcag cctcgcttcc ttgcagccaa gggctggggg 4260
ccagggctgc tgttctgcac tctggggtgg gtgaggggga ccctgggctg tttgctgtcc 4320
caagcccctt ctggaagtta gaagcagcaa agggcccggg gaagccgggc atgtgagagg 4380
ggtgcgtccc caggtccccc agagggccct gtcgccgagg acctttctga aggaagcaga 4440
agacgccatt tcctctactt cacactgaac tgtcccagcc actgcatcta gggggcattg 4500
ggcggaagat ggtgcatttc catggaccat tttacactta ccttttaaag caaagcctca 4560
ttttctaaac ccctgacttg tgaagcacaa ttcagcctcc gggctgggcc acgtggagag 4620
agaggatctt ctcagcaagg cgagatcccg ggcggcggct gacatcagga gcgccaccct 4680
gcgtcctttg ctgctggttc cttactggtt tgtacggtca gcgctggaaa cttctattaa 4740
atggatgcat tctggaggca tgaagttaca agtcaagtcg ccctgctcgt gtttccaagg 4800
ctctcacccc tcccagccac cccactttaa gggttacaaa cacctgctgg ggtccccacc 4860
ccaaccccat aggcaagccc ccattcccca gccaggccag gacagtcctt ccaaaactcg 4920
ggaaccaaat tgtatttggc tactggtgac tggatcctgg tagccaggaa acctgcctgg 4980
tggtgggggt cccagagtcc aggagggctg tctggtgagc tgcccatcag cctcacccct 5040
gcagccaggc atgtccctgg ggtgggcaca gagaccccag gctctgcccg cagtggcaca 5100
gaactcatct gaggccagtg gctgctgggg atcccctaca ctgggggtca gggctgcccc 5160
aggtggggat gtgtgtgcac ctcaccacgt tcacttcagg gtaccccaag aggctgaagg 5220
ggaaggacca aaaggccgag gtgcagcccc tccccggtgt cagggcagac aacacagcag 5280
ctgctggagg ggccggccct ggccacacag actagctagt cccttactcc cggcctgtct 5340
ggaaccctcc tgctcagaag gtgcccacta gccctctgtg ggggacagag ccagacatgg 5400
gtggtcaggg agaggctgtg tggattcagg ggaccagaaa gtaagtccca ggaccttgat 5460
ggagcggcag ggattgatgt tgggctaggg tggccagagc ctgtcccagc agggctgggg 5520
tctatcacgt tcctgggatc caagcagcga gcacgccctg ccccgcagtc accccgcccc 5580
gcagtcgccc tgcagctgga aggcccaagt ctgcctcacc tgggtggcct ctcatgtccc 5640
ccacaccctg gcccccaggc gaggggggct gcacagcacc tgcagggagg agaagggaga 5700
gaaaagccgg tctggctgct gggatgggag ggccacagtt ccagcagtgg caggggaagc 5760
tgtagcccct ggagccccac actggaagag ctggcctgca ggaggcacca tgggggagtc 5820
gcatgactta ttcgggattg acttgcgatg tggatggtgt tcccggagtc ccctgtggcc 5880
actccaccac catgaggccg ggaggcatct tagcctttga gcctctctcc aggggtgagc 5940
ggagcccccc aaagagggct gaaggcttgc tgcccaagag gggctgggtg agcacttggg 6000
gcctctgaga acatcagtgg tccgttccct cctgcacact ggtggcaagt ggcagcattt 6060
tttcataatc tccagtaatg aggccacttc gggtccagcc ctggacatcc gaggaggagg 6120
cgggcagtcc ctgccccttc actaaccgca gaggatgcca gctctaggcc ccctgctccg 6180
cctggagctc atgcgggcag ccgtggacac aggtggcacc cagcgcccag cggcctgtga 6240
atcctcccgt gggcaaagct gggagccagg ggctggaacc aggcaggtca gtgactgtga 6300
gatgccagct gccagcccaa gaaaagctgc ctgcagcatc tggaaacttc tgtgctctcc 6360
ttggcctctg tgttcttcat ctccaggttt agggagcacc cgggtgcctc tctgcttgtc 6420
ccgagcccac tcaccaacag ccccagcttg cacagtcatg acatcaggaa ggtgggtccc 6480
tgctcccagc cgtcctcgtc caccatcact tctcccagcc tcgtgtcctg ctgacccata 6540
aaaggtcccc ctgcaaagta caccaagtga agtaggatct gagcaaaggt tgagggactg 6600
aattccctaa gaagtcatca ctgcctagaa taagcgaaaa gaattttttt taatgtttta 6660
cggtagaatt atttgaaaca tacaaaatga gtgagacacc tgctattttc cttattcctg 6720
ttttttgttt gtttttattt tccttatacc taattcatct aacagaaaac tgggcagggc 6780
gcagtgtctc acacctgtaa tcccagcact ttgggaggcc aaggcaggtg gactgcttga 6840
gcccaggagt tgagtttaag atcagcgtgg gcaacatgat gaaccctgac tgtatcaaaa 6900
agtacaaaaa aaaaaatagc tagacgtggt ggcatgtgca tacagtccca ggtacccaag 6960
aggctgagga aggaggatca cctgagctgg ggaggttgag gctgccgtga gctgagatgg 7020
caccactgca ctccagcctg ggtggcagag agagaccctg tctcaaacaa aacaaacaaa 7080
caaaaaagaa aaagaaaata aaactgtttg ctcaaaatca gaa 7123
<210> 4
<400> 4
000
<210> 5
<400> 5
000
<210> 6
<400> 6
000
<210> 7
<400> 7
000
<210> 8
<400> 8
000
<210> 9
<400> 9
000
<210> 10
<400> 10
000
<210> 11
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Primer
<400> 11
gtcaacgtgc agaccatgt 19
<210> 12
<211> 22
<212> DNA
<213> Artificial sequence
<220>
<223> Primer
<400> 12
tcgctccctc ttttctagtt tg 22
<210> 13
<211> 23
<212> DNA
<213> Artificial sequence
<220>
<223> Probe
<400> 13
agctcaccca cccttccaac atg 23
<210> 14
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Primer
<400> 14
caggtggagt tctacgtcaa 20
<210> 15
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Primer
<400> 15
gagaagttga acagccggat 20
<210> 16
<211> 24
<212> DNA
<213> Artificial sequence
<220>
<223> Probe
<400> 16
tgatgaagaa cagcttgagc cgct 24
<210> 17
<400> 17
000
<210> 18
<400> 18
000
<210> 19
<400> 19
000
<210> 20
<400> 20
000
<210> 21
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 21
agtgggagcc gccaccttct 20
<210> 22
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 22
ctggcagctc ggacccgacc 20
<210> 23
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 23
gtgtagcccc cgccgcgcgc 20
<210> 24
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 24
ggagcgcgcc gtcccccgcg 20
<210> 25
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 25
caggtcgctc atcttgaagc 20
<210> 26
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 26
cgtagaactc cacctggacc 20
<210> 27
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 27
ggacgcgcac aatgtagagc 20
<210> 28
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 28
tcgcccacag tgtcatcttt 20
<210> 29
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 29
tattatggcc acgatgacct 20
<210> 30
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 30
gttgatcatc tccaggacga 20
<210> 31
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 31
acaggttctc gcccgcccgc 20
<210> 32
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 32
ggccacgcag atcatgatga 20
<210> 33
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 33
tgccgctcca tccagaggta 20
<210> 34
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 34
cgttcaggaa gtccatgaga 20
<210> 35
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 35
gaagtccttc acggcccagg 20
<210> 36
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 36
cttcagcccg atgaggcaca 20
<210> 37
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 37
gccgagttct cctccttggt 20
<210> 38
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 38
caggacgggc gcgatgctgg 20
<210> 39
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 39
acctcatcct ccgactggtc 20
<210> 40
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 40
agcttgttct tgaacccgta 20
<210> 41
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 41
tctgccgaga cgatgatcag 20
<210> 42
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 42
gttgtacagc ccattgccgg 20
<210> 43
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 43
gtagtaggcc cgcagtggca 20
<210> 44
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 44
gatgctgaag acgcggccgg 20
<210> 45
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 45
cagaggtacc ccgagcccgg 20
<210> 46
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 46
tgcaggctct tgcgccgtag 20
<210> 47
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 47
tgctggctga tccactccgc 20
<210> 48
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 48
atgcggttct tcaccagctc 20
<210> 49
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 49
ccaccgtgtc ctcacacgct 20
<210> 50
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 50
gtagagtgtg ccatccccag 20
<210> 51
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 51
agccctggtc acgagttgcg 20
<210> 52
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 52
tgccccctag atgcagtggc 20
<210> 53
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 53
ccatcttccg cccaatgccc 20
<210> 54
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 54
ggaaatgcac catcttccgc 20
<210> 55
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 55
ccgtacaaac cagtaaggaa 20
<210> 56
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 56
gcgctgaccg tacaaaccag 20
<210> 57
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 57
ggtttacccg attcatgaca 20
<210> 58
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 58
acacagcacc tttagacggg 20
<210> 59
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 59
actgctccct aatatgggcc 20
<210> 60
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 60
aaatgaccaa ctcactggcg 20
<210> 61
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 61
cctggcatag ccagacacgg 20
<210> 62
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 62
tgccgtaccc tacacgctgg 20
<210> 63
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 63
acttcctgcc caatatcgga 20
<210> 64
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 64
ggagggtcct ccaagcggct 20
<210> 65
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 65
ttcacggccc ctaaaccacc 20
<210> 66
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 66
ggaggatttc ccacgacatc 20
<210> 67
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 67
ggccattgag ccaccaaggg 20
<210> 68
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 68
cattttaacc ctctttgccg 20
<210> 69
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 69
tcaatcccga acaccatgtc 20
<210> 70
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 70
ggtccgaaat cccaagcctg 20
<210> 71
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 71
gtgccggaat cctcaccctt 20
<210> 72
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 72
accgggcaca gatcccacct 20
<210> 73
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 73
tccgtgagat ccacactcca 20
<210> 74
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 74
ggcttctatc tcacacccgt 20
<210> 75
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 75
ccgtctgctc aaaccatcag 20
<210> 76
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 76
ggcggtaccc agggaccacc 20
<210> 77
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 77
ccagccttcg ccatcgccag 20
<210> 78
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 78
gcgcctggct attgggagct 20
<210> 79
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 79
acctgtgtct cggctgaggc 20
<210> 80
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 80
cgtctcggct gaggcccacg 20
<210> 81
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 81
caccatggcc atacccatcg 20
<210> 82
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 82
gcattgcact tatccagcgc 20
<210> 83
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 83
gtccacccca gacgatccac 20
<210> 84
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 84
atggtccatc ccagaaggtc 20
<210> 85
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 85
agagggtcca ccatggatgg 20
<210> 86
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 86
ggtccaccca agagggtcca 20
<210> 87
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 87
tgtgcaggct gacagcgggt 20
<210> 88
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 88
tcctgcccca gacgcaccgt 20
<210> 89
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 89
gtgtgcacac gcgccctgcc 20
<210> 90
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 90
tcaggtaccg ccgctcaccc 20
<210> 91
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 91
gggctcttac ccacatactt 20
<210> 92
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 92
cgccagcctt accttgtcca 20
<210> 93
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 93
agctgtaccc acaggcggca 20
<210> 94
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 94
ccgagcatcc ccctacgcct 20
<210> 95
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 95
gttcgccctt actcatcagt 20
<210> 96
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 96
cacaggtcca taccccaccg 20
<210> 97
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 97
tccgagcacc acagtgcccg 20
<210> 98
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 98
tgcccggacc acacgcttct 20
<210> 99
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 99
cgagtgggag ccgccacctt 20
<210> 100
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 100
gcgccccgtc agggagtggc 20
<210> 101
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 101
tggtgtagcc cccgccgcgc 20
<210> 102
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 102
gtccaggagc gcgccgtccc 20
<210> 103
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 103
tcggagtcca ggtcgctcat 20
<210> 104
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 104
agccgctcct tgaaggtgtt 20
<210> 105
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 105
cgagcaggac gcgcacaatg 20
<210> 106
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 106
atcgcccaca gtgtcatctt 20
<210> 107
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 107
acacgcggaa gatctgctcc 20
<210> 108
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 108
gaacaggttc cgcagcggcg 20
<210> 109
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 109
ggacaggttc tcgcccgccc 20
<210> 110
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 110
cacgagggcc acgcagatca 20
<210> 111
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 111
gctgtagttg ccccctgact 20
<210> 112
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 112
tggacatcca tctccgtggg 20
<210> 113
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 113
gggcgaagtc cttcacggcc 20
<210> 114
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 114
cgcttcagcc cgatgaggca 20
<210> 115
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 115
ggccgagttc tcctccttgg 20
<210> 116
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 116
cggccagttc caggacgggc 20
<210> 117
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 117
cgtcacctca tcctccgact 20
<210> 118
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 118
cgagacgatg atcagcttgt 20
<210> 119
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 119
ctctgccgag acgatgatca 20
<210> 120
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 120
agttgtacag cccattgccg 20
<210> 121
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 121
cttgcgggat ctgtagtagg 20
<210> 122
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 122
gtagtccttc acgaaggact 20
<210> 123
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 123
acagaggtac cccgagcccg 20
<210> 124
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 124
ttgcggctca gcctccgggc 20
<210> 125
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 125
ctgctggctg atccactccg 20
<210> 126
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 126
catgcggttc ttcaccagct 20
<210> 127
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 127
tagtgccacc gtgtcctcac 20
<210> 128
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 128
gagtagagtg tgccatcccc 20
<210> 129
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 129
gacgcacccc tctcacatgc 20
<210> 130
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 130
aatgccccct agatgcagtg 20
<210> 131
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 131
caccatcttc cgcccaatgc 20
<210> 132
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 132
ccggaggctg aattgtgctt 20
<210> 133
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 133
accgtacaaa ccagtaagga 20
<210> 134
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 134
ccgattcatg acatcactgg 20
<210> 135
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 135
aggtttaccc gattcatgac 20
<210> 136
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 136
cccagcttct taccaggtcg 20
<210> 137
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 137
gggtacacga tacccgttca 20
<210> 138
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 138
gcaccgggcc ttatctgatc 20
<210> 139
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 139
gcacacggcc ataagcaggt 20
<210> 140
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 140
ctgccgtacc ctacacgctg 20
<210> 141
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 141
gcacagcacg ccaagaccgc 20
<210> 142
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 142
cggcacttcc accttaccca 20
<210> 143
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 143
tcctcgaacc ttcacggccc 20
<210> 144
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 144
tcggagagcc acgcccgtca 20
<210> 145
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 145
acaggaatct ttcgaaggcc 20
<210> 146
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 146
ccctccaaac aattatgcga 20
<210> 147
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 147
acagttcaat cccgaacacc 20
<210> 148
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 148
ctaggactat tatacccagc 20
<210> 149
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 149
tcgctttgcc taccgcgagc 20
<210> 150
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 150
ccggctcaaa ccaccgccag 20
<210> 151
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 151
cggcaggttc ccacacgcaa 20
<210> 152
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 152
ggcacggctt ctatctcaca 20
<210> 153
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 153
ccctttacct ccccgtggac 20
<210> 154
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 154
gcttgtcacc ccaccgggca 20
<210> 155
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 155
gccccacctt acaggtgcct 20
<210> 156
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 156
gagtggagac tcatcccacc 20
<210> 157
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 157
cacctgtgtc tcggctgagg 20
<210> 158
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 158
agtggtgacc aggcctcgct 20
<210> 159
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 159
gcccaccctt accatcgcca 20
<210> 160
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 160
gtcaggagcc tatgtctggg 20
<210> 161
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 161
tggtccaccc cagacgatcc 20
<210> 162
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 162
caccctggat ggtccaccct 20
<210> 163
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 163
aagagggtcc accatggatg 20
<210> 164
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 164
cccagacgat ccaccccaga 20
<210> 165
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 165
caccggtatc ccagtgcccc 20
<210> 166
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 166
cagacgcacc gtcacccacg 20
<210> 167
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 167
cgtgtgcaca cgcgccctgc 20
<210> 168
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 168
ggcacacgcc atacctgggc 20
<210> 169
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 169
cccccatgcc ctactcggtc 20
<210> 170
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 170
ggtgcctcta acatagacac 20
<210> 171
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 171
acagctgtac ccacaggcgg 20
<210> 172
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 172
cgtctctgta tatgcctggc 20
<210> 173
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 173
cgggttcgcc cttactcatc 20
<210> 174
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 174
gctgcccgta ttcttcctga 20
<210> 175
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 175
cgcaggcatc ccactcatga 20
<210> 176
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 176
tccggccttc ctgaccattc 20
<210> 177
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 177
ctggaggtag atgacccgct 20
<210> 178
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 178
cggacccgac ccgagggaga 20
<210> 179
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 179
ccgcgccccg tcagggagtg 20
<210> 180
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 180
gttggtgtag cccccgccgc 20
<210> 181
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 181
gccggcggtg tccaggagcg 20
<210> 182
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 182
acctcggagt ccaggtcgct 20
<210> 183
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 183
gagccgctcc ttgaaggtgt 20
<210> 184
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 184
ggagtagttc tgctttgggc 20
<210> 185
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 185
tggatcgccc acagtgtcat 20
<210> 186
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 186
cgaaggacac gcggaagatc 20
<210> 187
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 187
tgaacaggtt ccgcagcggc 20
<210> 188
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 188
gtcaccgtag cccacggtgg 20
<210> 189
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 189
gacgagctcc tcgaactgca 20
<210> 190
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 190
gtgcttctcc gtctgcgcac 20
<210> 191
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 191
atgcgctgcc actgctccgg 20
<210> 192
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 192
ccgcttcagc ccgatgaggc 20
<210> 193
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 193
gagccgttct ccgtgggcag 20
<210> 194
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 194
tcggccagtt ccaggacggg 20
<210> 195
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 195
gagggtagcc cttcacatac 20
<210> 196
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 196
ccgagacgat gatcagcttg 20
<210> 197
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 197
gccgtctctg ccgagacgat 20
<210> 198
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 198
aagttgtaca gcccattgcc 20
<210> 199
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 199
ttcagctcct tgcgggatct 20
<210> 200
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 200
tgtagtcctt cacgaaggac 20
<210> 201
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 201
acaggtcgcc ctcggtgatt 20
<210> 202
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 202
ccggcctgcc tgcttgggcg 20
<210> 203
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 203
gcgccggtac aggctgaggc 20
<210> 204
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 204
ccaggtgctt catgcggttc 20
<210> 205
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 205
cgctagtgcc accgtgtcct 20
<210> 206
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 206
ggccctcccc ccgcatgagg 20
<210> 207
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 207
ggacgcaccc ctctcacatg 20
<210> 208
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 208
gcccaatgcc ccctagatgc 20
<210> 209
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 209
gcaccatctt ccgcccaatg 20
<210> 210
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 210
cgggatctcg ccttgctgag 20
<210> 211
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 211
gaccgtacaa accagtaagg 20
<210> 212
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 212
tacccgattc atgacatcac 20
<210> 213
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 213
caggtttacc cgattcatga 20
<210> 214
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 214
cccttaaaga ccatccgccc 20
<210> 215
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 215
ctggcgggcc ccacacatcc 20
<210> 216
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 216
atggattttc atcacggcct 20
<210> 217
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 217
gcgcaccact cctccctgat 20
<210> 218
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 218
cctgccgtac cctacacgct 20
<210> 219
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 219
cggcacacaa cccatgtgcc 20
<210> 220
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 220
agcggcactt ccaccttacc 20
<210> 221
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 221
cccgactcct cctcgaacct 20
<210> 222
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 222
gtggcattcc atgttgaccc 20
<210> 223
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 223
accgtgtttc tacataagcc 20
<210> 224
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 224
gctgttacat ccgcagtgag 20
<210> 225
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 225
ccgtgtatac ctgtctcccc 20
<210> 226
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 226
acaacaagat ccaggcaccg 20
<210> 227
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 227
ggaaggacaa taccttcggc 20
<210> 228
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 228
tgcccggctc aaaccaccgc 20
<210> 229
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 229
cgcagcatcc aaacccacgg 20
<210> 230
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 230
cggcacacac tatagcctcg 20
<210> 231
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 231
tccgccctga ccatcgcccc 20
<210> 232
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 232
ggctcctatc aatcgaatct 20
<210> 233
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 233
ggacccttct ccctacgctg 20
<210> 234
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 234
tgggttccct acttactgag 20
<210> 235
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 235
acacctgtgt ctcggctgag 20
<210> 236
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 236
gccaggtccc agatgctatc 20
<210> 237
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 237
gcagcccacc cttaccatcg 20
<210> 238
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 238
ccggtcttcc aggcactcgc 20
<210> 239
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 239
atggtccacc ccagacgatc 20
<210> 240
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 240
atggtccacc ccagatggtc 20
<210> 241
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 241
caagagggtc caccatggat 20
<210> 242
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 242
ccggacagtc taccccagac 20
<210> 243
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 243
ccaccggtat cccagtgccc 20
<210> 244
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 244
ccagacgcac cgtcacccac 20
<210> 245
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 245
acacagctcg cctaactgcg 20
<210> 246
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 246
gggcagagtg cctactgcgc 20
<210> 247
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 247
cctcggcata acacatggcc 20
<210> 248
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 248
gatcagacac ccatgccggg 20
<210> 249
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 249
tcggccggcc acgccttact 20
<210> 250
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 250
gactcctctc acacaccggg 20
<210> 251
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 251
tccgggttcg cccttactca 20
<210> 252
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 252
gtgaagctgc gatgttctgg 20
<210> 253
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 253
acccgcttcc taaccctgca 20
<210> 254
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 254
gagttctgtg ccactgcggg 20
<210> 255
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 255
tcggacccga cccgagggag 20
<210> 256
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 256
tccgcgcccc gtcagggagt 20
<210> 257
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 257
caaactcgaa ggtccggttg 20
<210> 258
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 258
tcgctcatct tgaagccggc 20
<210> 259
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 259
cacctcggag tccaggtcgc 20
<210> 260
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 260
acagcttgag ccgctccttg 20
<210> 261
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 261
gacgagtcat tgaaggagta 20
<210> 262
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 262
ctggatcgcc cacagtgtca 20
<210> 263
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 263
ccaggacgaa ggacacgcgg 20
<210> 264
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 264
ccccgtgaaa acgaggcaca 20
<210> 265
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 265
cgatggccag atcttgggcg 20
<210> 266
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 266
agacgagctc ctcgaactgc 20
<210> 267
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 267
cgtgcttctc cgtctgcgca 20
<210> 268
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 268
ttcacggccc aggcgcgcag 20
<210> 269
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 269
ttgctgtcac ccatgcggat 20
<210> 270
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 270
ccccgggttc agcaggatgc 20
<210> 271
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 271
cgagccgttc tccgtgggca 20
<210> 272
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 272
tgtcggccag ttccaggacg 20
<210> 273
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 273
ggagggtagc ccttcacata 20
<210> 274
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 274
gccgagacga tgatcagctt 20
<210> 275
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 275
cggccgtctc tgccgagacg 20
<210> 276
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 276
cacgatgaag ttgtacagcc 20
<210> 277
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 277
gtccgcatag atgatgccac 20
<210> 278
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 278
atgtagtcct tcacgaagga 20
<210> 279
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 279
cggatccaca ggtcgccctc 20
<210> 280
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 280
ggctgatcca ctccgcggcc 20
<210> 281
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 281
cggttcttca ccagctcgga 20
<210> 282
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 282
gggtcggagc ggatgagata 20
<210> 283
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 283
gtcacgctag tgccaccgtg 20
<210> 284
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 284
tggccctccc cccgcatgag 20
<210> 285
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 285
gggacgcacc cctctcacat 20
<210> 286
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 286
ccgcccaatg ccccctagat 20
<210> 287
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 287
tgcaccatct tccgcccaat 20
<210> 288
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 288
ccgggatctc gccttgctga 20
<210> 289
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 289
ctgaccgtac aaaccagtaa 20
<210> 290
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 290
ttacccgatt catgacatca 20
<210> 291
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 291
ccaggtttac ccgattcatg 20
<210> 292
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 292
ggttctgacc acgctgttgc 20
<210> 293
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 293
aagatgccca tttaaccggg 20
<210> 294
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 294
aacttggaac ctctacctgg 20
<210> 295
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 295
cctccgcgcc ccaagtcggg 20
<210> 296
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 296
cctgaccatt ttcaacctcg 20
<210> 297
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 297
tgtcctatag acaccaacac 20
<210> 298
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 298
acgaagcttc ctcttgcctg 20
<210> 299
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 299
gacaccgttc acatgtgatg 20
<210> 300
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 300
ccttcgggag ccacacgctc 20
<210> 301
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 301
gggtacggcc tcatccaggt 20
<210> 302
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 302
ggtggctgtt acatccgcag 20
<210> 303
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 303
gtaacgaacc accaccagcc 20
<210> 304
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 304
agcccacacg ccatacagtt 20
<210> 305
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 305
ctgcagggcc cttcaccgcg 20
<210> 306
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 306
cccgcgcgcc cctacctctg 20
<210> 307
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 307
cccgatatag ccctagctga 20
<210> 308
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 308
gccccgtccc tacacggctg 20
<210> 309
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 309
ggccactcct cctaggcggg 20
<210> 310
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 310
agtcggctgc cttagccctc 20
<210> 311
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 311
agggtacatc ccacatctgc 20
<210> 312
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 312
acctggtttt cccccacgga 20
<210> 313
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 313
cacacctgtg tctcggctga 20
<210> 314
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 314
cggcacagcc agacaagcgc 20
<210> 315
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 315
cggaggatac atatctgctg 20
<210> 316
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 316
gggacttgcc aagcagtcct 20
<210> 317
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 317
ctgaatggtc caccccagac 20
<210> 318
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 318
atccaccctg gatggtccac 20
<210> 319
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 319
cacccaagag ggtccaccat 20
<210> 320
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 320
ggaactctac cttcagcccg 20
<210> 321
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 321
cagatacacc atcacccacg 20
<210> 322
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 322
gccccagacg caccgtcacc 20
<210> 323
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 323
ggtggacctt ccatcgctcc 20
<210> 324
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 324
ggttggctga ttctgggctc 20
<210> 325
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 325
ggacttagcc ccatcagggc 20
<210> 326
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 326
gtgacctgac aattgacccc 20
<210> 327
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 327
gaccaactga ccatgccagg 20
<210> 328
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 328
cggatgagcc cttcctgagc 20
<210> 329
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 329
gggtcattct tcagcggagg 20
<210> 330
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 330
gtgtgccctt accgtagccg 20
<210> 331
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 331
aacccgcttc ctaaccctgc 20
<210> 332
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 332
tgcgactccc ccatggtgcc 20
<210> 333
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 333
agctcggacc cgacccgagg 20
<210> 334
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 334
gtccgcgccc cgtcagggag 20
<210> 335
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 335
cgtcaaactc gaaggtccgg 20
<210> 336
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 336
gtcgctcatc ttgaagccgg 20
<210> 337
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 337
tagaactcca cctggaccct 20
<210> 338
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 338
gagaagttga acagccggat 20
<210> 339
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 339
ggaggacgag tcattgaagg 20
<210> 340
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 340
acctggatcg cccacagtgt 20
<210> 341
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 341
gatcatctcc aggacgaagg 20
<210> 342
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 342
gtgctggatg ccgcaggtcc 20
<210> 343
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 343
cacgcagatc atgatgacca 20
<210> 344
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 344
ccagaggtag acgagctcct 20
<210> 345
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 345
aaggtcgatc ttgagggagc 20
<210> 346
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 346
ccttcacggc ccaggcgcgc 20
<210> 347
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 347
tcgcggaaga acttgctgtc 20
<210> 348
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 348
cgagttctcc tccttggtga 20
<210> 349
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 349
cgccggctgc ccgagccgtt 20
<210> 350
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 350
agctgtcggc cagttccagg 20
<210> 351
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 351
ttcttgaacc cgtaggcctt 20
<210> 352
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 352
tgccgagacg atgatcagct 20
<210> 353
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 353
ttgccggccg tctctgccga 20
<210> 354
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 354
cagtggcacg atgaagttgt 20
<210> 355
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 355
ccaggttgtc cgcatagatg 20
<210> 356
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 356
tcatgtagtc cttcacgaag 20
<210> 357
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 357
gtgcggatcc acaggtcgcc 20
<210> 358
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 358
tggctgatcc actccgcggc 20
<210> 359
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 359
gcggttcttc accagctcgg 20
<210> 360
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 360
ttgcaggacg acagcttgtg 20
<210> 361
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 361
ccagggtcac gctagtgcca 20
<210> 362
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 362
gttgcggtac atctgtgtaa 20
<210> 363
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 363
ccttcagaaa ggtcctcggc 20
<210> 364
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 364
atcttccgcc caatgccccc 20
<210> 365
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 365
atgcaccatc ttccgcccaa 20
<210> 366
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 366
gcccgggatc tcgccttgct 20
<210> 367
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 367
gctgaccgta caaaccagta 20
<210> 368
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 368
tttacccgat tcatgacatc 20
<210> 369
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 369
ccccagatcg ccagcccgtc 20
<210> 370
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 370
gcaccaagac ctatggactc 20
<210> 371
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 371
ggcgacggtg ccaaggagga 20
<210> 372
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 372
gagcgcatca ctattttctc 20
<210> 373
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 373
tgggctcatc ctgttggtcc 20
<210> 374
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 374
tagaatattc cattccccgc 20
<210> 375
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 375
ctcatcctat agacaccaac 20
<210> 376
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 376
acttccccga ccagctgaga 20
<210> 377
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 377
gcgggattcg ccctctcagg 20
<210> 378
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 378
ccctcgccga ccactggcct 20
<210> 379
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 379
caggttctac ctaccaaggg 20
<210> 380
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 380
atcaccataa ccagacccgg 20
<210> 381
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 381
tgcaacattt tcaagcctcg 20
<210> 382
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 382
gcaatggaag ccacactcga 20
<210> 383
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 383
gcgctcccga tacctgccct 20
<210> 384
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 384
ttgaccttag cctcaaccgc 20
<210> 385
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 385
tcggcctacg ccaggctctc 20
<210> 386
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 386
gggcgcagcc acacactcgc 20
<210> 387
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 387
gggtgacttc ccaactggct 20
<210> 388
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 388
tggctcacct accgtggcca 20
<210> 389
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 389
gggctaaccc ccacatcaga 20
<210> 390
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 390
ctgtgaggtg ccatcccggg 20
<210> 391
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 391
tctcggctga ggcccacggg 20
<210> 392
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 392
ggtgagattt acggattggg 20
<210> 393
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 393
acaatctccc ccaaagcggc 20
<210> 394
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 394
cccggacgat ccaccctgga 20
<210> 395
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 395
cctgaatggt ccaccccaga 20
<210> 396
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 396
caccctagac aatccaccct 20
<210> 397
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 397
tccacccaag agggtccacc 20
<210> 398
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 398
atggcctacg cccttgccct 20
<210> 399
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 399
tgccccagac gcaccgtcac 20
<210> 400
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 400
acgcgccctg ccccagacgc 20
<210> 401
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 401
gacctcaacc ccctacttgg 20
<210> 402
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 402
cggcgagttc ccagagctca 20
<210> 403
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 403
ccgttcttcc cttaaccacc 20
<210> 404
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 404
ccggccacag attataaccc 20
<210> 405
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 405
ggagttctga ccaactgacc 20
<210> 406
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 406
gcatccagaa ttccagccgt 20
<210> 407
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 407
gctcgccacc cctcatgcat 20
<210> 408
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 408
gccgtgtgcc cttaccgtag 20
<210> 409
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 409
tgctcgcccc ccaacccgct 20
<210> 410
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 410
gggaggattc acaggccgct 20
<210> 411
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 411
cagctcggac ccgacccgag 20
<210> 412
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 412
gtagcccccg ccgcgcgcct 20
<210> 413
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 413
gcgcgccgtc ccccgcgcag 20
<210> 414
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 414
aggtcgctca tcttgaagcc 20
<210> 415
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 415
gtagaactcc acctggaccc 20
<210> 416
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 416
gacgcgcaca atgtagagca 20
<210> 417
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 417
ccagttgatc tcggaggacg 20
<210> 418
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 418
ttatggccac gatgacctgg 20
<210> 419
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 419
ttgatcatct ccaggacgaa 20
<210> 420
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 420
ttctcgcccg cccgctccag 20
<210> 421
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 421
ccacgcagat catgatgacc 20
<210> 422
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 422
ccgctccatc cagaggtaga 20
<210> 423
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 423
tgagaaggtc gatcttgagg 20
<210> 424
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 424
tccttcacgg cccaggcgcg 20
<210> 425
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 425
actcgcggaa gaacttgctg 20
<210> 426
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 426
ccgagttctc ctccttggtg 20
<210> 427
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 427
ccgccggctg cccgagccgt 20
<210> 428
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 428
cctcatcctc cgactggtcg 20
<210> 429
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 429
gttcttgaac ccgtaggcct 20
<210> 430
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 430
ctgccgagac gatgatcagc 20
<210> 431
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 431
ttgtacagcc cattgccggc 20
<210> 432
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 432
gcagtggcac gatgaagttg 20
<210> 433
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 433
cggcggcgaa cggcaggcgg 20
<210> 434
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 434
cagccgggtg atggtgatca 20
<210> 435
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 435
cgtgcggatc cacaggtcgc 20
<210> 436
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 436
gctggctgat ccactccgcg 20
<210> 437
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 437
tgcggttctt caccagctcg 20
<210> 438
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 438
accgtgtcct cacacgctcc 20
<210> 439
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 439
ccccagggtc acgctagtgc 20
<210> 440
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 440
agttgcggta catctgtgta 20
<210> 441
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 441
ggacagttca gtgtgaagta 20
<210> 442
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 442
catcttccgc ccaatgcccc 20
<210> 443
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 443
gaaatgcacc atcttccgcc 20
<210> 444
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 444
agccgccgcc cgggatctcg 20
<210> 445
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 445
cgctgaccgt acaaaccagt 20
<210> 446
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 446
gtttacccga ttcatgacat 20
<210> 447
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 447
ggagaactgc gatttctgtc 20
<210> 448
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 448
cccctctgaa ccatagcacc 20
<210> 449
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 449
aatgaccaac tcactggcgc 20
<210> 450
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 450
cgcgggagcc ccaaacccac 20
<210> 451
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 451
agcggatgaa ttattcccat 20
<210> 452
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 452
gtagaatatt ccattccccg 20
<210> 453
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 453
tgtcccatcc tatagacacc 20
<210> 454
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 454
cactcacgcc ttcacgcaga 20
<210> 455
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 455
tggtggcttc ctgacgcgga 20
<210> 456
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 456
cagactggcc acgcccctcg 20
<210> 457
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 457
cactcgcctt tttagagccc 20
<210> 458
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 458
tctcagattc acaatcccgg 20
<210> 459
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 459
ccccctcgcc acgcatggtt 20
<210> 460
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 460
gccggaatcc tcacccttag 20
<210> 461
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 461
ccggcccgcc ccaaactcac 20
<210> 462
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 462
cgtgagatcc acactccaga 20
<210> 463
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 463
ggtgacaacc acactcgagg 20
<210> 464
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 464
gggaacatcg ccattcccag 20
<210> 465
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 465
ccaccgggcc ctaaaagcat 20
<210> 466
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 466
ttcgccatcg ccaggcttgc 20
<210> 467
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 467
cgcctggcta ttgggagctg 20
<210> 468
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 468
gccccggctt acaatcatgt 20
<210> 469
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 469
gtctcggctg aggcccacgg 20
<210> 470
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 470
atggccatac ccatcgatgc 20
<210> 471
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 471
aagcagcccc agggattgcg 20
<210> 472
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 472
caccccggac gatccaccct 20
<210> 473
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 473
accctgaatg gtccacccca 20
<210> 474
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 474
gagatccatc ccagatggtt 20
<210> 475
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 475
gtccacccaa gagggtccac 20
<210> 476
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 476
ggtggagacc ccacctaggt 20
<210> 477
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 477
ctgccccaga cgcaccgtca 20
<210> 478
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 478
cacgcgccct gccccagacg 20
<210> 479
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 479
ccggccttac ttcttgtggg 20
<210> 480
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 480
gcactcactc taccacggag 20
<210> 481
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 481
gtagcccttc acatacctgg 20
<210> 482
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 482
gtggttcatt ccagactgga 20
<210> 483
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 483
gtcccttgtc aatacaagga 20
<210> 484
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 484
tcgcccttac tcatcagtgg 20
<210> 485
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 485
aggtccatac cccaccggcc 20
<210> 486
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 486
ggtccccacc agtcttgttc 20
<210> 487
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 487
tccgaccttt actccaggcc 20
<210> 488
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 488
cgggtgctcc ctaaacctgg 20
<210> 489
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 489
acagcacgcc aagaccgcta 20
<210> 490
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 490
cgtgccccac cctcaccttt 20
<210> 491
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 491
actggcagaa tcatcagtaa 20
<210> 492
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 492
agcgaactta attatatctc 20
<210> 493
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 493
caccccagac gatccaccct 20
<210> 494
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 494
ccacactcca ctccaaggca 20
<210> 495
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 495
ctcccatcct atacacacca 20
<210> 496
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 496
cgccattccc agagtccaca 20
<210> 497
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 497
gccttgccac acaaaacagt 20
<210> 498
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 498
agcacatcct ggccttgccc 20
<210> 499
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 499
ggttctgccc tcttctgacc 20
<210> 500
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 500
gactcaccca accctaccat 20
<210> 501
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 501
ccacacgcaa caaaggcacc 20
<210> 502
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 502
gatgacggtc ccatgctgat 20
<210> 503
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 503
ctctcacacc tctaagagcc 20
<210> 504
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 504
gcgaggccac ccatgtgaaa 20
<210> 505
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 505
agctgaacca cccacagaga 20
<210> 506
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 506
caccgtgtaa caacacccca 20
<210> 507
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 507
accgcaaccc cttctgcttg 20
<210> 508
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 508
ctgccgtttt caagaattaa 20
<210> 509
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 509
acccttagcc ctcatcagga 20
<210> 510
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 510
gactctagtt acaaacatga 20
<210> 511
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 511
acgatccatt ttcccctgca 20
<210> 512
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 512
agagggagtc ctatcattca 20
<210> 513
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 513
cctggtgcca cacctccctt 20
<210> 514
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 514
cctccatgca cccgtgccac 20
<210> 515
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 515
tcacgggact ccatcattac 20
<210> 516
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 516
cggacacaca acatacgcaa 20
<210> 517
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 517
gttttaagca caccatcccg 20
<210> 518
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 518
cttcatagca acccatgcct 20
<210> 519
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 519
caccctggac agtctaccct 20
<210> 520
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 520
gaaagccaca cacaactggc 20
<210> 521
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 521
ggcaggcccc ttccctctca 20
<210> 522
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 522
gtacatccca catctgcggg 20
<210> 523
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 523
ggcataaaca cacttacacc 20
<210> 524
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 524
cccccgacat acacagcatc 20
<210> 525
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 525
accagcccaa gcatacccca 20
<210> 526
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 526
ggagtactct ccacagaccc 20
<210> 527
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 527
ggaggtcccc tccgtggccg 20
<210> 528
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 528
gcccatggct tcatcaacgg 20
<210> 529
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 529
gaacacagaa tcctgtgaac 20
<210> 530
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 530
gggacccttc tccctacgct 20
<210> 531
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 531
ccctgcccca gacgcaccgt 20
<210> 532
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 532
ttgaccccac cccagaggca 20
<210> 533
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 533
acccagtcat gaactaggtc 20
<210> 534
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 534
gcccctgttc tattttgagc 20
<210> 535
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 535
tctactctgc ccaaggccct 20
<210> 536
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 536
gtgtcctcac acgctcctcc 20
<210> 537
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 537
ccttgcagaa ttcttgcagc 20
<210> 538
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 538
tagcaaagct gatctagccc 20
<210> 539
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 539
agacgcatcc atttcctcca 20
<210> 540
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 540
ggcactggct cctatcaatc 20
<210> 541
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 541
gggcttttcc caggcaggcc 20
<210> 542
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 542
taatcagctc ccaatccctc 20
<210> 543
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 543
ctgtgtccac acctgcggga 20
<210> 544
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 544
cttcatgcct ccagaatgca 20
<210> 545
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 545
tgaagattcc tccccgcagc 20
<210> 546
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 546
accagacccc agaatctcct 20
<210> 547
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 547
accagcagca tccttaataa 20
<210> 548
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 548
cagcccggcc ttacttcttg 20
<210> 549
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 549
cccaggcaaa ccgcccagca 20
<210> 550
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 550
gacctttact ccaggcctca 20
<210> 551
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 551
acgaaggtca ccatccacct 20
<210> 552
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 552
ttggacacca tcccgggcct 20
<210> 553
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 553
cagagtgcag aacagcagcc 20
<210> 554
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 554
gccctgttct ctgaagcaac 20
<210> 555
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 555
atcactgtcc caatcacccc 20
<210> 556
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 556
tccatggaaa tgcaccatct 20
<210> 557
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 557
gggccagtcc ccttctctac 20
<210> 558
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 558
caagagaaca tctgtgccgt 20
<210> 559
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 559
cagtagggca ccacagccac 20
<210> 560
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 560
gtgaggtgcc atcccgggca 20
<210> 561
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 561
ggcggtacat ccacgggctc 20
<210> 562
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 562
ggtgccttcc tttgccgtaa 20
<210> 563
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 563
cttccacctt acccagacct 20
<210> 564
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 564
gtggtccccc tcgccacgca 20
<210> 565
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 565
agacccctca ccaaacatcc 20
<210> 566
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 566
cggcaggtcc ctgacaggca 20
<210> 567
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 567
ttcatagcaa cccatgccta 20
<210> 568
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 568
gtagggcacc acagccacta 20
<210> 569
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 569
gagacgggct tccttgcatc 20
<210> 570
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 570
gcatctgtat cccctcgccc 20
<210> 571
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 571
tcctgtgaac ttcctcccct 20
<210> 572
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 572
cactggctcc tatcaatcga 20
<210> 573
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 573
agatggtcca ccccacatga 20
<210> 574
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 574
ccagggctga cccttggact 20
<210> 575
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 575
ggacacacaa catacgcaac 20
<210> 576
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 576
ccatgggcct ccacctgctc 20
<210> 577
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 577
aaggtcacca tccacctggc 20
<210> 578
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 578
cagcacggcc tccccgagct 20
<210> 579
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 579
agtctgggcc ctccaggccg 20
<210> 580
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 580
acacaccaac accacagggc 20
<210> 581
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 581
cccctgttct attttgagcc 20
<210> 582
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 582
ccagacgatc caccctaaat 20
<210> 583
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 583
cccaccctca cctttgggtc 20
<210> 584
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 584
cctttactcc aggcctcagt 20
<210> 585
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 585
gagtactctc cacagacccc 20
<210> 586
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 586
tggtgccaca cctcccttca 20
<210> 587
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 587
actggaaacc atccacagat 20
<210> 588
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 588
ttctgccctc ttctgaccta 20
<210> 589
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 589
cacaggtgct actcacacaa 20
<210> 590
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 590
ttcatgcctc cagaatgcat 20
<210> 591
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 591
ccgttttcaa gaattaacca 20
<210> 592
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 592
gaggaagcca ccacctgtca 20
<210> 593
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 593
tgtgtcctga ccattttcaa 20
<210> 594
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 594
caaaggcacc cccttatctc 20
<210> 595
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 595
gagagaagcc tctctctgtt 20
<210> 596
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 596
acttggcccc aaacctaggc 20
<210> 597
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 597
aagccacaca caactggctt 20
<210> 598
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 598
actaggtcac ccacccagga 20
<210> 599
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 599
tacatcccac atctgcggga 20
<210> 600
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 600
aagctgatct agcccaggtc 20
<210> 601
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 601
ccttgccaca caaaacagtt 20
<210> 602
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 602
ccgtggccaa ctctcgggtc 20
<210> 603
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 603
tcccagagtc cacacccggc 20
<210> 604
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 604
tggctttttc catcctggga 20
<210> 605
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 605
gcatcctgcc ccagacgcac 20
<210> 606
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 606
gctacagctc ccatgctgca 20
<210> 607
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 607
gaaccaccca cagagaggcc 20
<210> 608
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 608
tgtgtccaca cctgcgggat 20
<210> 609
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 609
tggaaatgca ccatcttccg 20
<210> 610
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 610
ggcttcggcc tcactcacct 20
<210> 611
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 611
gggcaggcac tcactttgta 20
<210> 612
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 612
cccgggcctt tcctgctcca 20
<210> 613
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 613
gaagccgcac ctccactgcc 20
<210> 614
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 614
tttaagcaca ccatcccgga 20
<210> 615
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 615
cacactccac tccaaggcaa 20
<210> 616
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 616
gctgagggtc ccaaacccag 20
<210> 617
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 617
cggccttact tcttgtgggc 20
<210> 618
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 618
gacgcatcca tttcctccac 20
<210> 619
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 619
aggatcttcg caacttgctg 20
<210> 620
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 620
ccctcaccaa acatcccccg 20
<210> 621
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 621
atttggccca ccacacacgg 20
<210> 622
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 622
agccctgatc cctcttgcaa 20
<210> 623
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 623
agagtgcaga acagcagccc 20
<210> 624
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 624
tcactgtccc aatcaccccc 20
<210> 625
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 625
aatcagctcc caatccctcc 20
<210> 626
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 626
tgacggtccc atgctgatca 20
<210> 627
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 627
gcgatctgtc ttcacgagtc 20
<210> 628
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 628
ctggcagaat catcagtaac 20
<210> 629
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 629
gcgaacttaa ttatatctcc 20
<210> 630
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 630
cccatggctt catcaacgga 20
<210> 631
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 631
gcagtggtta tactgaacct 20
<210> 632
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 632
ctaagagccc ttgtctgcca 20
<210> 633
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 633
acctgagaca cccccatggc 20
<210> 634
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 634
ggctgttaca tccgcagtga 20
<210> 635
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 635
tctgaagcaa ccccccagct 20
<210> 636
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 636
gaagcaagcc cctttgggca 20
<210> 637
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 637
acgggactcc atcattaccc 20
<210> 638
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 638
ggagtgagtc ccagtggtta 20
<210> 639
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 639
agggagtcct atcattcaga 20
<210> 640
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 640
gccgccagcc ttaccttgtc 20
<210> 641
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 641
aaacacactt acacccattc 20
<210> 642
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 642
ccagcagcat ccttaataat 20
<210> 643
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 643
cactgtccca atcaccccca 20
<210> 644
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 644
tccctcctgt cctatacaca 20
<210> 645
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 645
ccaggaagct tattatggcc 20
<210> 646
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 646
ggtagcccca acccaacagc 20
<210> 647
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 647
gacggcctga cacctgcccc 20
<210> 648
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 648
ccgctggctc ttttctgccc 20
<210> 649
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 649
tggttatact gaacctgttt 20
<210> 650
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 650
aaatgcacca tcttccgccc 20
<210> 651
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 651
tcatgcctcc agaatgcatc 20
<210> 652
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 652
gccctcttct gacctagaca 20
<210> 653
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 653
gacgatccac cctaaatggt 20
<210> 654
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 654
ccacagaccc ctccttctga 20
<210> 655
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 655
ggctttttcc atcctgggac 20
<210> 656
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 656
ccctgttcta ttttgagcct 20
<210> 657
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 657
ctgaagcaac cccccagctt 20
<210> 658
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 658
ccaccctcac ctttgggtca 20
<210> 659
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 659
ggcgcagcca cacactcgcc 20
<210> 660
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 660
ggtgccacac ctcccttcaa 20
<210> 661
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 661
gggagtccta tcattcagaa 20
<210> 662
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 662
aacacactta cacccattcc 20
<210> 663
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 663
tggcagagca tctcactgac 20
<210> 664
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 664
ctgttgttct cccctccgct 20
<210> 665
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 665
ctacagctcc catgctgcac 20
<210> 666
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 666
gtggtttgct ttcctgatct 20
<210> 667
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 667
ggcctgtgca ctctccaccc 20
<210> 668
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 668
tgcagcaccc ataagtgggc 20
<210> 669
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 669
gccgcacctc cactgccaca 20
<210> 670
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 670
gcctgggcag ccataaagcc 20
<210> 671
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 671
cgtggccaac tctcgggtca 20
<210> 672
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 672
acgcatccat ttcctccaca 20
<210> 673
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 673
cctcaccaaa catcccccgt 20
<210> 674
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 674
acactccact ccaaggcaac 20
<210> 675
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 675
ccggaggtcc gaaatcccaa 20
<210> 676
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 676
ccgccagcct taccttgtcc 20
<210> 677
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 677
gagagcctcc cagccacgca 20
<210> 678
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 678
catctgtatc ccctcgcccg 20
<210> 679
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 679
gatgagcttc tctccacgcc 20
<210> 680
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 680
gtgagacctc ttgattgccc 20
<210> 681
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 681
tctgctcgcc ccccaacccg 20
<210> 682
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 682
agacagttcc tcccttgcaa 20
<210> 683
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 683
cctgtgaact tcctcccctt 20
<210> 684
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 684
ccttgcatct ctcactgggc 20
<210> 685
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 685
actggctcct atcaatcgaa 20
<210> 686
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 686
aaccacccac agagaggcca 20
<210> 687
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 687
atcctgcccc agacgcaccg 20
<210> 688
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 688
ccgggccttt cctgctccaa 20
<210> 689
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 689
tggtccaccc cacatgatct 20
<210> 690
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 690
tcatagcaac ccatgcctat 20
<210> 691
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 691
gtcccatgct gatcaagttc 20
<210> 692
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 692
ggcagaatca tcagtaacaa 20
<210> 693
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 693
acaactggct tcttctagaa 20
<210> 694
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 694
acacaatacc actcagacac 20
<210> 695
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 695
acaggtgcta ctcacacaat 20
<210> 696
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 696
cttggcccca aacctaggcc 20
<210> 697
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 697
cctgagacac ccccatggcc 20
<210> 698
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 698
tgtgggtcac acaggacagg 20
<210> 699
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 699
cgaacttaat tatatctccc 20
<210> 700
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 700
gccactgcga cctcattccg 20
<210> 701
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 701
aggagattcc ttctagggta 20
<210> 702
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 702
cttctgcacc cattcctgct 20
<210> 703
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 703
cgcccataca tgcgctgcca 20
<210> 704
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 704
ggcaccacag ccactagtgt 20
<210> 705
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 705
aaggcacccc cttatctcgg 20
<210> 706
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 706
tgtcctgacc attttcaacc 20
<210> 707
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 707
tcaggacacc gcaagtgctc 20
<210> 708
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 708
cgggactcca tcattaccca 20
<210> 709
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 709
aacagtttcc acagctggga 20
<210> 710
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 710
cctgtctccc ccaaagtggc 20
<210> 711
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 711
ctgagggtcc caaacccagc 20
<210> 712
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 712
tgtcagatgt cccacagcct 20
<210> 713
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 713
ttggcccacc acacacggca 20
<210> 714
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 714
atgtttgtca cagaaagtcc 20
<210> 715
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 715
cgatctgtct tcacgagtca 20
<210> 716
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 716
gccctgatcc ctcttgcaaa 20
<210> 717
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 717
gagtgcagaa cagcagccct 20
<210> 718
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 718
aagcaagccc ctttgggcaa 20
<210> 719
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 719
ttcttcagca cccatgctga 20
<210> 720
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 720
cgtgtatgcc atctccacct 20
<210> 721
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 721
aacttaatta tatctcccgt 20
<210> 722
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 722
cgctggctct tttctgcccc 20
<210> 723
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 723
tgctcaagac tccagggcga 20
<210> 724
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 724
gaaggacaat accttcggca 20
<210> 725
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 725
ccttgactaa tcactgtgga 20
<210> 726
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 726
gtagaggatc cacccaggga 20
<210> 727
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 727
caggaagctt attatggcca 20
<210> 728
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 728
ccactccaag gcaacaccca 20
<210> 729
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 729
agggtagccc ttcacatacc 20
<210> 730
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 730
gcagacaaag aacccggcca 20
<210> 731
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 731
ccactgcgac ctcattccgc 20
<210> 732
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 732
gtcatgtgtc caccacacgc 20
<210> 733
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 733
tggtttgctt tcctgatctc 20
<210> 734
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 734
ttctgcaccc attcctgctc 20
<210> 735
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 735
ggtgctactc acacaatgtc 20
<210> 736
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 736
tgcaaagcac ttactgagac 20
<210> 737
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 737
gggcacggct tctatctcac 20
<210> 738
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 738
gtcctcagca ctcactgaac 20
<210> 739
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 739
gctttttcca tcctgggaca 20
<210> 740
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 740
ccctgatccc tcttgcaaac 20
<210> 741
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 741
ctggctccta tcaatcgaat 20
<210> 742
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 742
caagtgctca gaacatgccg 20
<210> 743
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 743
agcaaccccc cagcttgtcc 20
<210> 744
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 744
tcctgctcca ataaaccaga 20
<210> 745
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 745
caccacagcc actagtgtcc 20
<210> 746
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 746
gggactccat cattacccac 20
<210> 747
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 747
ttggccccaa acctaggcca 20
<210> 748
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 748
ggcccaagcc tccttgctgc 20
<210> 749
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 749
ccccagacgc accgtcaccc 20
<210> 750
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 750
gacacggcac ttcccgggac 20
<210> 751
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 751
gcagccataa agcctgccta 20
<210> 752
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 752
gcttgtccca ctcagggcct 20
<210> 753
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 753
tgagacaccc ccatggccaa 20
<210> 754
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 754
catgcctcca gaatgcatcc 20
<210> 755
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 755
tcattgtgaa atcccatgcc 20
<210> 756
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 756
gcgcagccac acactcgcca 20
<210> 757
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 757
tccacggaac tccatgggtc 20
<210> 758
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 758
gtactaagag ctactggcca 20
<210> 759
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 759
aatgcaccat cttccgccca 20
<210> 760
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 760
gctgagccgc catcatgctc 20
<210> 761
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 761
ctgctcgccc cccaacccgc 20
<210> 762
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 762
acggcctgac acctgcccct 20
<210> 763
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 763
acacacttac acccattcca 20
<210> 764
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 764
ctcgggtcat tcttcagcgg 20
<210> 765
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 765
atgccaggcc cccttgtgac 20
<210> 766
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 766
agggagataa actaaactct 20
<210> 767
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 767
gcagcaccca taagtgggca 20
<210> 768
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 768
caactggctt cttctagaac 20
<210> 769
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 769
ggccacaccc ttcctcctga 20
<210> 770
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 770
tgatcaagtt ctaatgggaa 20
<210> 771
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 771
tggcatggat cccctcccta 20
<210> 772
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 772
cctatggtat ccacagaccc 20
<210> 773
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 773
gtcctgacca ttttcaacct 20
<210> 774
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 774
gtagccccaa cccaacagca 20
<210> 775
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 775
ggcaccccct tatctcgggc 20
<210> 776
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 776
gaagagaaac ccttcaggcc 20
<210> 777
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 777
gagggtccca aacccagcaa 20
<210> 778
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 778
ccacagtccc agcccccgga 20
<210> 779
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 779
atgagcttct ctccacgcca 20
<210> 780
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 780
ccagacacac atcacatatc 20
<210> 781
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 781
tccctcccgt cctatagaca 20
<210> 782
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 782
cgcacctcca ctgccacaga 20
<210> 783
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 783
gcgctggcac caacaagatc 20
<210> 784
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 784
ctgtgaactt cctccccttc 20
<210> 785
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 785
ggtggaaact tctgcaggac 20
<210> 786
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 786
atctgtatcc cctcgcccgg 20
<210> 787
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 787
tacagctccc atgctgcact 20
<210> 788
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 788
cgttgccctc ccagccagcc 20
<210> 789
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 789
tcaccaaaca tcccccgtga 20
<210> 790
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 790
attttgagcc tccctagaac 20
<210> 791
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 791
acgatccacc ctaaatggtc 20
<210> 792
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 792
cttgcatctc tcactgggct 20
<210> 793
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 793
tgttgttctc ccctccgctc 20
<210> 794
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 794
gaggtccgaa atcccaagcc 20
<210> 795
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 795
ggtccacccc acatgatcta 20
<210> 796
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 796
ggagtcctat cattcagaac 20
<210> 797
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 797
tctgccccac atagaaacca 20
<210> 798
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 798
ctatcattca gaacagggac 20
<210> 799
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 799
gcaaagcact tactgagaca 20
<210> 800
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 800
gcacggcttc tatctcacac 20
<210> 801
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 801
gactccatca ttacccacca 20
<210> 802
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 802
ggcatggatc ccctccctat 20
<210> 803
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 803
cccgtgaaca cccagccgtt 20
<210> 804
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 804
cctgctccaa taaaccagac 20
<210> 805
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 805
aactggcttc ttctagaaca 20
<210> 806
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 806
ggctgcccca gaacctccga 20
<210> 807
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 807
ggctgggaac tcacaattct 20
<210> 808
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 808
cattgtgaaa tcccatgcca 20
<210> 809
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 809
acagaattaa ttagctaatc 20
<210> 810
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 810
gcttctctcc acgccaggca 20
<210> 811
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 811
tagtgtcccc cagccaccct 20
<210> 812
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 812
ctgtcagaca ccccagggct 20
<210> 813
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 813
tcgggtcatt cttcagcgga 20
<210> 814
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 814
agcaagtgcc ctcccccgac 20
<210> 815
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 815
gagggacccc actgtggaca 20
<210> 816
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 816
aggaagctta ttatggccac 20
<210> 817
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 817
agaggatcca cccagggact 20
<210> 818
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 818
atccctcttg caaacacacc 20
<210> 819
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 819
ttgctttcct gatctcaaca 20
<210> 820
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 820
aggtctagga ctattatacc 20
<210> 821
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 821
ttgacacaca acacacatta 20
<210> 822
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 822
gggtagccct tcacatacct 20
<210> 823
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 823
gttgttctcc cctccgctcc 20
<210> 824
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 824
cccaacccgc ttcctaaccc 20
<210> 825
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 825
cggatttgct agctgagccc 20
<210> 826
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 826
ctgactgtcc ccctctgttt 20
<210> 827
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 827
acgcaggtgc agcccagcca 20
<210> 828
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 828
taggccagga caacaactca 20
<210> 829
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 829
tttgatgtca ctgcctggcc 20
<210> 830
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 830
ccaacagcaa cacactggtt 20
<210> 831
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 831
aggtccgaaa tcccaagcct 20
<210> 832
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 832
cagcagcacc cacttatcac 20
<210> 833
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 833
cctccagaat gcatccattt 20
<210> 834
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 834
ccaagcctcc ttgctgcggc 20
<210> 835
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 835
tcatgtgtcc accacacgcc 20
<210> 836
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 836
cgatccaccc taaatggtcc 20
<210> 837
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 837
cttcagcatt cactgagcct 20
<210> 838
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 838
tctgtatccc ctcgcccggc 20
<210> 839
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 839
gggagataaa ctaaactctt 20
<210> 840
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 840
ccccaggcta acatgctgaa 20
<210> 841
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 841
ccgtcaggac ccaagccctc 20
<210> 842
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 842
tccaaggcaa cacccagcca 20
<210> 843
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 843
acttaattat atctcccgtg 20
<210> 844
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 844
tagggcaccc tctcttacat 20
<210> 845
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 845
cactgcgacc tcattccgcc 20
<210> 846
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 846
cggcctgaca cctgcccctc 20
<210> 847
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 847
tgctcagaaa atgaccaact 20
<210> 848
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 848
gtgctactca cacaatgtca 20
<210> 849
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 849
tgtgaacttc ctccccttcc 20
<210> 850
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 850
caggccttct ctccagggaa 20
<210> 851
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 851
tgggaacctc cttagtggcc 20
<210> 852
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 852
agcagcagtc ccagaagccc 20
<210> 853
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 853
gctatgggcc actgcagcct 20
<210> 854
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 854
gtcctgcccc agacgcaccg 20
<210> 855
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 855
acacttacac ccattccatt 20
<210> 856
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 856
agcttgtccc taagttggcc 20
<210> 857
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 857
gctccggaca cccaccagga 20
<210> 858
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 858
ttggagtccc cacccctgca 20
<210> 859
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 859
cgcagccaca cactcgccac 20
<210> 860
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 860
tactggccaa cctatgtgga 20
<210> 861
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 861
ccacggaact ccatgggtcc 20
<210> 862
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 862
tgacaaagat ttccctagac 20
<210> 863
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 863
cacaccagcc cttccgtcca 20
<210> 864
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 864
cgtggcccac catccgatgc 20
<210> 865
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 865
gtgtatgcca tctccacctc 20
<210> 866
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 866
tctgcaccca ttcctgctcc 20
<210> 867
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 867
ggcactgtgt caacttgata 20
<210> 868
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 868
ctgggcagaa cctgctatcc 20
<210> 869
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 869
gacccctgca cactcactca 20
<210> 870
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 870
caccccacat gatctacact 20
<210> 871
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 871
cccctcctgt cctatagaca 20
<210> 872
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 872
gcagcaccca cttatcactt 20
<210> 873
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 873
gctactcaca caatgtcact 20
<210> 874
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 874
gcccgtctca cctctgccag 20
<210> 875
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 875
gagaagctgc taactccaga 20
<210> 876
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 876
tcgcccggcc ctgcttgcct 20
<210> 877
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 877
tagcccttca catacctggg 20
<210> 878
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 878
gggccaggtc cactcccatc 20
<210> 879
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 879
cgcgcgcccc tacctctggc 20
<210> 880
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 880
gtctaggact attataccca 20
<210> 881
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 881
gctgggaact cacaattctc 20
<210> 882
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 882
gcacggcaac cctccagggc 20
<210> 883
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 883
aaaggagcct accttgcctt 20
<210> 884
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 884
ttgcggtaca tctgtgtaaa 20
<210> 885
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 885
cctgccccag acgcaccgtc 20
<210> 886
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 886
cccctgcaca ctcactcata 20
<210> 887
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 887
gggctgtcgg tcacttgtca 20
<210> 888
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 888
tcagaaaatg accaactcac 20
<210> 889
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 889
gtgaacttcc tccccttccg 20
<210> 890
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 890
tgccccagaa cctccgaggt 20
<210> 891
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 891
cctcttgcaa acacaccctt 20
<210> 892
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 892
cgtacttgca ctcctcctca 20
<210> 893
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 893
cggacaccca ccaggagagc 20
<210> 894
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 894
actggcttct tctagaacac 20
<210> 895
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 895
ccatcattac ccaccatgct 20
<210> 896
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 896
ccaggacccc atcccagtgt 20
<210> 897
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 897
acagtgacaa ccccgaccct 20
<210> 898
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 898
gatccaccct aaatggtcca 20
<210> 899
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 899
tacacccatt ccatttcagc 20
<210> 900
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 900
caacagcaac acactggttc 20
<210> 901
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 901
gggaacctcc ttagtggccc 20
<210> 902
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 902
actgcgacct cattccgcca 20
<210> 903
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 903
aacctgctat ccctatgggc 20
<210> 904
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 904
agacgaggcc tttaaagcgg 20
<210> 905
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 905
tccgctagct cctcagagtc 20
<210> 906
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 906
tgacacacaa cacacattac 20
<210> 907
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 907
catgggtcca cacctgatgc 20
<210> 908
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 908
gtggcccacc atccgatgcc 20
<210> 909
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 909
ggctggtgac cccaacatct 20
<210> 910
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 910
cctgggttcc ctacttactg 20
<210> 911
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 911
cacggcttct atctcacacc 20
<210> 912
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 912
gtatgccatc tccacctcct 20
<210> 913
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 913
agcctgttca tctcagcagc 20
<210> 914
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 914
gccttgaccc tcactcccat 20
<210> 915
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 915
ccaacccgct tcctaaccct 20
<210> 916
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 916
caaggcaaca cccagccagc 20
<210> 917
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 917
gcagggttca ccccgatggc 20
<210> 918
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 918
aattagctaa tcatcaggtt 20
<210> 919
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 919
accatcttcc gcccaatgcc 20
<210> 920
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 920
ggagataaac taaactcttc 20
<210> 921
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 921
gccaggacaa caactcagga 20
<210> 922
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 922
gtgaaatccc atgccagctt 20
<210> 923
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 923
gcttgtccct aagttggcca 20
<210> 924
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 924
agtctgtgtc ctccaagggc 20
<210> 925
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 925
gcaagtgccc tcccccgaca 20
<210> 926
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 926
cccacatgat ctacactgga 20
<210> 927
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 927
actggccaac ctatgtggaa 20
<210> 928
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 928
gccgaggtcc ctccagtggc 20
<210> 929
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 929
ctgctccaat aaaccagacc 20
<210> 930
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 930
ttgtggtcca cttctcagct 20
<210> 931
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 931
cacggaggcc acacttcccc 20
<210> 932
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 932
agaggctcga ccctatggct 20
<210> 933
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 933
gctgaaatct tctacaggaa 20
<210> 934
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 934
atgtgtccac cacacgcccc 20
<210> 935
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 935
atacctgtct ccccattcct 20
<210> 936
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 936
ccaggcttca ccgagctcct 20
<210> 937
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 937
gctcttttcc caaaacccat 20
<210> 938
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 938
agctctgtgc aaacaaggtc 20
<210> 939
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 939
gaacacccag ccgttagcct 20
<210> 940
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 940
ccgatgttct ccctccaaac 20
<210> 941
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 941
ccagaatgca tccatttaat 20
<210> 942
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 942
gaagtggtca tccctgcacc 20
<210> 943
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 943
gacaaagatt tccctagact 20
<210> 944
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 944
cggtgaccac caccctcccc 20
<210> 945
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 945
ttgttctccc ctccgctccg 20
<210> 946
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 946
ggcaccctct cttacatcca 20
<210> 947
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 947
tgactgtccc cctctgtttc 20
<210> 948
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 948
agcccaagca cacttcccac 20
<210> 949
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 949
acacccattc catttcagct 20
<210> 950
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 950
ctgggttccc tacttactga 20
<210> 951
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 951
gggcagtcgc cactctgcct 20
<210> 952
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 952
atcattaccc accatgctga 20
<210> 953
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 953
gaggctcgac cctatggcta 20
<210> 954
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 954
ctcggtgatt ttcatctgca 20
<210> 955
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 955
gagttctgac caactgacca 20
<210> 956
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 956
caccctctct tacatccagt 20
<210> 957
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 957
gagcacaccc ctctgccggc 20
<210> 958
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 958
tacctgtctc cccattcctc 20
<210> 959
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 959
tcgagggcac ccactccacc 20
<210> 960
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 960
acggcttcta tctcacaccc 20
<210> 961
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 961
gctggtgacc ccaacatctc 20
<210> 962
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 962
tgcgacctca ttccgccaac 20
<210> 963
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 963
atcgctccag tccttgcttc 20
<210> 964
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 964
cctgcttgcc tctcgggccc 20
<210> 965
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 965
tcacttgtca ccatggccat 20
<210> 966
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 966
atgggtccac acctgatgct 20
<210> 967
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 967
cccgtctcac ctctgccagt 20
<210> 968
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 968
cctccctttt tccttccgga 20
<210> 969
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 969
tctaggacta ttatacccag 20
<210> 970
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 970
gcacccactt atcacttctc 20
<210> 971
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 971
cagccgttag cctctcggcc 20
<210> 972
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 972
agctgctaac tccagaagga 20
<210> 973
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 973
gatggtgaca accacaccac 20
<210> 974
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 974
gtacttgcac tcctcctcac 20
<210> 975
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 975
ccgtacccta cacgctggaa 20
<210> 976
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 976
ccgaggtccc tccagtggca 20
<210> 977
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 977
gctcaaacca ccgccaggac 20
<210> 978
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 978
gacgaggcct ttaaagcggt 20
<210> 979
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 979
agtggtcatc cctgcaccca 20
<210> 980
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 980
ctccaaacaa ttatgcgatt 20
<210> 981
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 981
tggagacctc tcctctgctt 20
<210> 982
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 982
gagctgcctt gaacaaggct 20
<210> 983
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 983
ctggatggtc caccctgaac 20
<210> 984
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 984
cttttcccaa aacccatggt 20
<210> 985
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 985
ctaaatggtc caccccggac 20
<210> 986
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 986
acggaggcca cacttccccc 20
<210> 987
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 987
agaaaatgac caactcactg 20
<210> 988
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 988
ggccaggtcc actcccatcc 20
<210> 989
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 989
gaaatcttct acaggaagcc 20
<210> 990
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 990
ccggctgttc ccctccacct 20
<210> 991
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 991
tgtggtccac ttctcagctt 20
<210> 992
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 992
ctggatttgt ccatactccc 20
<210> 993
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 993
taggttaaaa aactctcctc 20
<210> 994
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 994
acaaagattt ccctagactt 20
<210> 995
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 995
gtcggctgca caaaccctgc 20
<210> 996
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 996
gcatgccgtc ctccacatcc 20
<210> 997
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 997
ctgggtggca ccttcagaaa 20
<210> 998
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 998
tcttccgccc aatgccccct 20
<210> 999
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 999
gctccaataa accagacctt 20
<210> 1000
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1000
aactgagtgc ccaaaactac 20
<210> 1001
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1001
tgggaactca caattctcaa 20
<210> 1002
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1002
gagataaact aaactcttca 20
<210> 1003
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1003
caggacccca tcccagtgtc 20
<210> 1004
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1004
cgcttcctaa ccctgcaggc 20
<210> 1005
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1005
cagaatgcat ccatttaata 20
<210> 1006
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1006
gagctgagtc tttccggcct 20
<210> 1007
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1007
aagcacactt cccaccacaa 20
<210> 1008
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1008
gacacccacc aggagagcca 20
<210> 1009
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1009
ggcccaccat ccgatgccca 20
<210> 1010
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1010
atcccatgcc agcttctcct 20
<210> 1011
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1011
gtccgtagca gaacttggct 20
<210> 1012
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1012
agagactcgc tcatcagcga 20
<210> 1013
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1013
aaggagccta ccttgccttt 20
<210> 1014
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1014
cccagctcca tcctgattca 20
<210> 1015
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1015
ccccctctgt ttcaaagctc 20
<210> 1016
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1016
aggcaacacc cagccagctc 20
<210> 1017
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1017
acctgctatc cctatgggcc 20
<210> 1018
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1018
ttgaccctca ctcccatgtc 20
<210> 1019
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1019
ggtgacttcc caactggctc 20
<210> 1020
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1020
gacacacccc ccttgcacac 20
<210> 1021
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1021
tgtgtccacc acacgccccc 20
<210> 1022
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1022
atgctgctcc atgggagcac 20
<210> 1023
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1023
acggcaaccc tccagggccg 20
<210> 1024
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1024
ggagaccaca gaactccaga 20
<210> 1025
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1025
ctactgaccc cagcttgcca 20
<210> 1026
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1026
gcctgacagc ccctgtgcca 20
<210> 1027
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1027
gtggcacctt cagaaaggcc 20
<210> 1028
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1028
ctttccggcc ttcctgacca 20
<210> 1029
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1029
gagctcgcaa aaggctgccc 20
<210> 1030
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1030
aactgccctt ttagagagca 20
<210> 1031
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1031
ggagacctct cctctgcttc 20
<210> 1032
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1032
tggtgttgct caactccaga 20
<210> 1033
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1033
ggccacactt ccccccggaa 20
<210> 1034
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1034
acccgagaca ccatctggta 20
<210> 1035
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1035
cgcacaggca caaaatgccc 20
<210> 1036
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1036
catgccgtcc tccacatcca 20
<210> 1037
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1037
gggcatcaac cagaatgcgg 20
<210> 1038
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1038
ggatggtcca ccctgaacag 20
<210> 1039
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1039
gaccttgact caatcatgca 20
<210> 1040
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1040
ggcatggttc tctctaggcg 20
<210> 1041
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1041
cgagcatccc cctacgcctc 20
<210> 1042
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1042
ccaactgacc atgccaggac 20
<210> 1043
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1043
cacacttccc accacaaggc 20
<210> 1044
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1044
cggctgttcc cctccacctg 20
<210> 1045
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1045
accacagaac tccagaagca 20
<210> 1046
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1046
cccccaaccc tccatcggtc 20
<210> 1047
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1047
actgagtgcc caaaactaca 20
<210> 1048
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1048
gaatgcatcc atttaataga 20
<210> 1049
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1049
gccccagacg caccgtcaca 20
<210> 1050
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1050
agggagacac accctcccca 20
<210> 1051
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1051
ccctttttcc ttccggagtc 20
<210> 1052
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1052
accacacgcc cccccacgca 20
<210> 1053
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1053
cggcttctat ctcacacccg 20
<210> 1054
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1054
gactcgctca tcagcgagaa 20
<210> 1055
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1055
aggaccccat cccagtgtcc 20
<210> 1056
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1056
ttgcctgtcc tcaccagggt 20
<210> 1057
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1057
ctggtgaccc caacatctcc 20
<210> 1058
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1058
tggatttgtc catactccca 20
<210> 1059
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1059
cacccactta tcacttctca 20
<210> 1060
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1060
gaactcacaa ttctcaaact 20
<210> 1061
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1061
cctgtctgtc ttcagcattc 20
<210> 1062
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1062
ccccatgccc tactcggtct 20
<210> 1063
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1063
catgtgtgca tacaccggca 20
<210> 1064
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1064
cacccattcc atttcagctg 20
<210> 1065
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1065
tgaccctcac tcccatgtca 20
<210> 1066
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1066
attccgccaa ctcctggccc 20
<210> 1067
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1067
cctctcttac atccagtcga 20
<210> 1068
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1068
cgtgagtcct cagagcactt 20
<210> 1069
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1069
tacttgcact cctcctcaca 20
<210> 1070
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1070
ccccattcct cctttgtata 20
<210> 1071
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1071
gataaactaa actcttcacc 20
<210> 1072
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1072
cttccgccca atgcccccta 20
<210> 1073
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1073
cctgcaccca cctcgcaggc 20
<210> 1074
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1074
cggctgcaca aaccctgcca 20
<210> 1075
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1075
tcggtgattt tcatctgcag 20
<210> 1076
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1076
ccgtagtgac cctaaaagtc 20
<210> 1077
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1077
gtgacttccc aactggctct 20
<210> 1078
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1078
gcctcgcttt accctcccaa 20
<210> 1079
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1079
taggactatt atacccagcc 20
<210> 1080
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1080
ggtgacaacc acaccacaca 20
<210> 1081
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1081
cctgctatcc ctatgggccc 20
<210> 1082
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1082
atgctgagca ccaccggacc 20
<210> 1083
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1083
acgaggcctt taaagcggtc 20
<210> 1084
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1084
tccagggaac ccctttcctt 20
<210> 1085
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1085
gcctggcggc caacagcacc 20
<210> 1086
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1086
aggtccactc ccatccttca 20
<210> 1087
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1087
ccctctgttt caaagctcca 20
<210> 1088
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1088
accatggcca tacccatcga 20
<210> 1089
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1089
gaaggttccc caagagagga 20
<210> 1090
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1090
gccgttagcc tctcggccca 20
<210> 1091
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1091
gcttcctaac cctgcaggcc 20
<210> 1092
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1092
gctacgcttc cttggaggcc 20
<210> 1093
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1093
cgctcccgat acctgcccta 20
<210> 1094
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1094
gtccttgctt cccctgctca 20
<210> 1095
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1095
aacagccgga tcctcaggcc 20
<210> 1096
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1096
agaggaagct cctatcccca 20
<210> 1097
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1097
aggttaaaaa actctcctca 20
<210> 1098
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1098
ccggacgatc caccctggac 20
<210> 1099
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1099
ggtgctcaca ctgacggccg 20
<210> 1100
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1100
ccggtgagac tcatgggcat 20
<210> 1101
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1101
gagggcaccc actccaccca 20
<210> 1102
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1102
cggacgatcc accctggaca 20
<210> 1103
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1103
cttcagcatt cactaaagtc 20
<210> 1104
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1104
ccccagacgc accgtcacac 20
<210> 1105
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1105
tagcccagca caccccatct 20
<210> 1106
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1106
gccacacttc cccccggaac 20
<210> 1107
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1107
tggccatacc catcgatgca 20
<210> 1108
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1108
tgccacagcc tcagtggcac 20
<210> 1109
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1109
cctaagctgc ttctgaggac 20
<210> 1110
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1110
tcagacagtc ccttgtgtac 20
<210> 1111
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1111
gttgagctgc caaccggtcc 20
<210> 1112
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1112
ccgtccagcc ccactctacc 20
<210> 1113
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1113
caggctggca tctctaaggc 20
<210> 1114
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1114
ggacagggac caactcccgg 20
<210> 1115
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1115
tcatctcctt ctccagcgac 20
<210> 1116
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1116
cctgcagccc atgacactac 20
<210> 1117
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1117
gcattgggaa ttacaacctg 20
<210> 1118
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1118
gtctgtggac ctcaaccccc 20
<210> 1119
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1119
agccagggcc catccctgac 20
<210> 1120
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1120
cgaggccttt aaagcggtca 20
<210> 1121
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1121
tactcggtct ttctcctccc 20
<210> 1122
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1122
gagggcagct ctagtaggtt 20
<210> 1123
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1123
ggtccaccct gaacagtcca 20
<210> 1124
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1124
actggttccc agacacccct 20
<210> 1125
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1125
tgtgcataca ccggcaggcc 20
<210> 1126
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1126
ggtccactcc catccttcac 20
<210> 1127
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1127
gtggagaccc cacctaggtg 20
<210> 1128
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1128
cgtagtgacc ctaaaagtcc 20
<210> 1129
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1129
acacttccca ccacaaggcg 20
<210> 1130
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1130
atgccgtcct ccacatccac 20
<210> 1131
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1131
cgctgcttcc accaagatta 20
<210> 1132
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1132
cctccatcgg tcataggcct 20
<210> 1133
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1133
acgcagagct ctgtgtgccc 20
<210> 1134
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1134
ccacttatca cttctcagtt 20
<210> 1135
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1135
gtggaagtca ttctgtggaa 20
<210> 1136
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1136
tcacacggcc atctccttct 20
<210> 1137
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1137
tgagtgccca aaactacagc 20
<210> 1138
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1138
ggctgctcca cagtgggtat 20
<210> 1139
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1139
gatcactgcc ctcccccttc 20
<210> 1140
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1140
aggactatta tacccagcca 20
<210> 1141
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1141
agggcaccca ctccacccac 20
<210> 1142
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1142
cctcactccc atgtcaggac 20
<210> 1143
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1143
gtgacaacca caccacacac 20
<210> 1144
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1144
ctgtttcaaa gctccagcta 20
<210> 1145
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1145
actaaactct tcacctgggc 20
<210> 1146
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1146
cccgatacct gccctagcgc 20
<210> 1147
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1147
actgcccttt tagagagcac 20
<210> 1148
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1148
caccagggtc ctcacccccc 20
<210> 1149
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1149
gcccacagcc ctttcacggc 20
<210> 1150
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1150
tcttacatcc agtcgaggca 20
<210> 1151
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1151
tactgacccc agcttgccat 20
<210> 1152
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1152
gctcttggca tccacggtca 20
<210> 1153
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1153
cccgagacac catctggtaa 20
<210> 1154
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1154
aacagcacct tgactagcac 20
<210> 1155
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1155
cccaatgccc cctagatgca 20
<210> 1156
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1156
ggccgacaac cagatggaaa 20
<210> 1157
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1157
gcacaggcac aaaatgcccc 20
<210> 1158
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1158
ggctgcacaa accctgccaa 20
<210> 1159
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1159
cctaagggct ttctcaccca 20
<210> 1160
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1160
gtgattttca tctgcagggt 20
<210> 1161
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1161
ccagggaacc cctttccttg 20
<210> 1162
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1162
tgcatccatt taatagaagt 20
<210> 1163
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1163
gcttctatct cacacccgtc 20
<210> 1164
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1164
cccattcctc ctttgtataa 20
<210> 1165
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1165
aagtgattaa aacattcgat 20
<210> 1166
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1166
cttgccttca cttgcaggca 20
<210> 1167
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1167
ccttggcctc cagatacggc 20
<210> 1168
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1168
gagacctctc ctctgcttca 20
<210> 1169
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1169
cttgactcaa tcatgcaggt 20
<210> 1170
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1170
actcacaatt ctcaaactgc 20
<210> 1171
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1171
cctcgcttta ccctcccaac 20
<210> 1172
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1172
gcatggttct ctctaggcgg 20
<210> 1173
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1173
tctttatcct tccactgggc 20
<210> 1174
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1174
ccacagaact ccagaagcaa 20
<210> 1175
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1175
gtgacaacca cactcgagga 20
<210> 1176
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1176
cacctggtgt ccaaactcac 20
<210> 1177
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1177
ggttaaaaaa ctctcctcac 20
<210> 1178
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1178
gtgttgctca actccagaga 20
<210> 1179
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1179
cacttggaca cagtgagcaa 20
<210> 1180
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1180
tcacaattct caaactgctc 20
<210> 1181
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1181
tgcacaagaa cttcctgcca 20
<210> 1182
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1182
agtggcaccc tccctctact 20
<210> 1183
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1183
agtgcccaaa actacagcgg 20
<210> 1184
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1184
gctgcttcca ccaagattac 20
<210> 1185
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1185
tccctttacc tccccgtgga 20
<210> 1186
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1186
ggctttctca cccagagccg 20
<210> 1187
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1187
ggcctgaacc agctctatct 20
<210> 1188
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1188
gcatccattt aatagaagtt 20
<210> 1189
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1189
ggcaggtgcc catccaccca 20
<210> 1190
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1190
tctgtggacc tcaaccccct 20
<210> 1191
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1191
gcgcacggcc ccatctgaac 20
<210> 1192
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1192
cttggcctcc agatacggcc 20
<210> 1193
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1193
gttaaaaaac tctcctcact 20
<210> 1194
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1194
gaacagtcca tcccagatga 20
<210> 1195
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1195
cccacagccc tttcacggcc 20
<210> 1196
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1196
ccacacctgc ctctcggctc 20
<210> 1197
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1197
ggccttagtc ctattgaatt 20
<210> 1198
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1198
aggctgcaat tcaacactgc 20
<210> 1199
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1199
gctgagtaag gaaaatcccc 20
<210> 1200
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1200
ggtcccctgt ttactgatcc 20
<210> 1201
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1201
gcccgttctt cccttaacca 20
<210> 1202
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1202
ttcgatgttt cccaaagctc 20
<210> 1203
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1203
atggccggca ccctcccccg 20
<210> 1204
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1204
gagacattca cccagggctg 20
<210> 1205
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1205
gacaagcggc ccccaagcca 20
<210> 1206
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1206
ggacgatcca ccctggacag 20
<210> 1207
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1207
acctggtgtc caaactcaca 20
<210> 1208
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1208
caaagcttct cctctctgga 20
<210> 1209
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1209
tgtcaggaca gtcttagcca 20
<210> 1210
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1210
gggaattaca acctgaagcc 20
<210> 1211
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1211
gcggagagcc cacacgccat 20
<210> 1212
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1212
gctgggtgtt tacccaagac 20
<210> 1213
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1213
actcggtctt tctcctccca 20
<210> 1214
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1214
gccataccca tcgatgcaat 20
<210> 1215
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1215
ccctcaaccc ccatgcacgc 20
<210> 1216
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1216
gtgacgagca cccagtggga 20
<210> 1217
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1217
cacttcccac cacaaggcgc 20
<210> 1218
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1218
cagaactcga ttcacaggta 20
<210> 1219
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1219
cgcctgagca ctcttacgca 20
<210> 1220
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1220
tctgaggcca tcttgaggga 20
<210> 1221
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1221
ggagagggcc acccttcagc 20
<210> 1222
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1222
tctaccccag acaatccacc 20
<210> 1223
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1223
tgttgctcaa ctccagagaa 20
<210> 1224
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1224
gcaaacaccc ctgaaagaca 20
<210> 1225
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1225
taggcggaca gcaaaagcct 20
<210> 1226
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1226
tgggtcagcc tccaagaggc 20
<210> 1227
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1227
ctaaactctt cacctgggca 20
<210> 1228
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1228
aggctggcat ctctaaggca 20
<210> 1229
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1229
atccgcagca tccaaaccca 20
<210> 1230
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1230
cctaaaagtc ctatctgccc 20
<210> 1231
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1231
ccatggcgaa caacttgtcc 20
<210> 1232
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1232
gtcgaggcaa tttctcagga 20
<210> 1233
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1233
ccagggccca tccctgaccg 20
<210> 1234
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1234
gttgggagaa aaacaaccac 20
<210> 1235
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1235
ttatgacacc cattctggac 20
<210> 1236
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1236
cacttatcac ttctcagttc 20
<210> 1237
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1237
accttgacta gcacaagccc 20
<210> 1238
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1238
ccagcacacc ccatctcagt 20
<210> 1239
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1239
gctgagatag aaacaatggc 20
<210> 1240
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1240
tttcaaagct ccagctacac 20
<210> 1241
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1241
cccacggcca cacctgtgtc 20
<210> 1242
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1242
gtccagcccc actctaccct 20
<210> 1243
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1243
atccacggtc actcccgcct 20
<210> 1244
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1244
caatgccccc tagatgcagt 20
<210> 1245
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1245
atccaagtaa acatcgccag 20
<210> 1246
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1246
ccagacgcac cgtcacacat 20
<210> 1247
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1247
gagggtccac catcaggtcc 20
<210> 1248
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1248
tcctcacccc ccaattccta 20
<210> 1249
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1249
ccttcccccc acgccagcat 20
<210> 1250
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1250
tctccagcga ctctgaacct 20
<210> 1251
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1251
ctttatcctt ccactgggcc 20
<210> 1252
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1252
ctcgctttac cctcccaaca 20
<210> 1253
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1253
ccatctcctt ctgcctgtta 20
<210> 1254
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1254
tgccgtcctc cacatccaca 20
<210> 1255
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1255
cttctatctc acacccgtca 20
<210> 1256
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1256
ggcagaagcc cccaactcac 20
<210> 1257
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1257
aaagcttctc ctctctggac 20
<210> 1258
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1258
cgtggctcac ctaccgtggc 20
<210> 1259
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1259
gccgtcctcc acatccacac 20
<210> 1260
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1260
ggacagtcca cctagatggt 20
<210> 1261
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1261
cccacgccag catccaggaa 20
<210> 1262
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1262
agcaaaagcc tctgctgtcc 20
<210> 1263
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1263
ctggcaagac cacgaagcca 20
<210> 1264
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1264
gttccgtgaa tttccctgaa 20
<210> 1265
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1265
ggagagccca cacgccatac 20
<210> 1266
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1266
gcaggtgccc atccacccac 20
<210> 1267
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1267
ccacagccct ttcacggcct 20
<210> 1268
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1268
ctaaaagtcc tatctgccca 20
<210> 1269
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1269
tgagatagaa acaatggcct 20
<210> 1270
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1270
aaaaaactct cctcactagc 20
<210> 1271
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1271
aaactcttca cctgggcatt 20
<210> 1272
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1272
tccagcgact ctgaacctct 20
<210> 1273
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1273
ggctgcaatt caacactgcc 20
<210> 1274
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1274
cacacctgcc tctcggctct 20
<210> 1275
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1275
cagggcccat ccctgaccga 20
<210> 1276
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1276
ccagctctat cttcccagac 20
<210> 1277
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1277
gcctgagcac tcttacgcat 20
<210> 1278
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1278
aacagtccat cccagatgac 20
<210> 1279
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1279
gcttccacca agattaccct 20
<210> 1280
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1280
tcatggtgcc cacccccaca 20
<210> 1281
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1281
acacagcccc acccctgcgg 20
<210> 1282
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1282
gaggccttgc ccaacagggc 20
<210> 1283
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1283
cccactctac cctctggcat 20
<210> 1284
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1284
aggccactcc acttcttgga 20
<210> 1285
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1285
gtggacctca accccctact 20
<210> 1286
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1286
gctttaccct cccaacaggt 20
<210> 1287
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1287
aactgactcc aggatcccta 20
<210> 1288
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1288
ttcaaagctc cagctacacc 20
<210> 1289
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1289
ttaatagaag tttccagcgc 20
<210> 1290
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1290
gcagggaacc ccaccacatc 20
<210> 1291
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1291
ggccaccagc tcatttcact 20
<210> 1292
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1292
agcacacccc atctcagtga 20
<210> 1293
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1293
cgttcttccc ttaaccacct 20
<210> 1294
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1294
tccgcagcat ccaaacccac 20
<210> 1295
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1295
gccttagtcc tattgaatta 20
<210> 1296
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1296
tcgatgtttc ccaaagctca 20
<210> 1297
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1297
ccccaagcca cctggaacca 20
<210> 1298
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1298
ggccatttct caggctggcc 20
<210> 1299
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1299
cccgcctgaa tcccccacgc 20
<210> 1300
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1300
gacaatccac cccagagggt 20
<210> 1301
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1301
ggtctgagca cacgctccta 20
<210> 1302
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1302
ctcggtcttt ctcctcccac 20
<210> 1303
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1303
acttcccacc acaaggcgca 20
<210> 1304
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1304
tccaagtaaa catcgccagt 20
<210> 1305
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1305
aggacagtct tagccaccaa 20
<210> 1306
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1306
gatggacgat atctcctgga 20
<210> 1307
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1307
tatgacaccc attctggaca 20
<210> 1308
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1308
ttggcctcca gatacggcca 20
<210> 1309
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1309
gagagggcca cccttcagcc 20
<210> 1310
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1310
accacagcca cctcaaagat 20
<210> 1311
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1311
ttctatctca cacccgtcac 20
<210> 1312
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1312
ctcacccccc aattcctacc 20
<210> 1313
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1313
aggtctcttc cctcagggac 20
<210> 1314
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1314
tgtgcataac acaaatattg 20
<210> 1315
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1315
agtgagctcc caactctgtc 20
<210> 1316
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1316
ggtgtccaaa ctcacaggct 20
<210> 1317
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1317
tcacaggtaa aagacacgac 20
<210> 1318
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1318
gagcaatgcc cacaaaggtg 20
<210> 1319
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1319
gtcttctgct tccttcagaa 20
<210> 1320
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1320
taaattggca ttaatgtctt 20
<210> 1321
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1321
cgcacggccc catctgaact 20
<210> 1322
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1322
gggctcagcc ctttcagacc 20
<210> 1323
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1323
ggcaccctcc ctctactggc 20
<210> 1324
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1324
gtgcccaaaa ctacagcggt 20
<210> 1325
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1325
ccacggccac acctgtgtct 20
<210> 1326
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1326
aacctgaagc ccaaacggtt 20
<210> 1327
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1327
gtcacctgtt ttactgagcc 20
<210> 1328
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1328
gggtgtttac ccaagacagc 20
<210> 1329
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1329
gtctgcgcac agctgagctt 20
<210> 1330
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1330
cacaattctc aaactgctcc 20
<210> 1331
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1331
ccgaagctct aatccctggc 20
<210> 1332
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1332
gttgctcaac tccagagaac 20
<210> 1333
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1333
tggcaagacc acgaagccaa 20
<210> 1334
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1334
cccaaagctc acaacactca 20
<210> 1335
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1335
gtggctcacc taccgtggcc 20
<210> 1336
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1336
ggctggcccc acatgcaggc 20
<210> 1337
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1337
ccctggtgcc ttctacaggc 20
<210> 1338
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1338
cagcgactct gaacctctgc 20
<210> 1339
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1339
ctttaccctc ccaacaggtt 20
<210> 1340
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1340
ctccaggatc cctatgggct 20
<210> 1341
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1341
aggcaccacc agatgccaca 20
<210> 1342
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1342
cggtctttct cctcccacca 20
<210> 1343
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1343
aaaaactctc ctcactagcc 20
<210> 1344
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1344
ggctcagccc tttcagacct 20
<210> 1345
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1345
tgtcccagac catcatcgat 20
<210> 1346
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1346
acgcacccct ctcacatgcc 20
<210> 1347
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1347
gggaaacccc ccaagtcctc 20
<210> 1348
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1348
tcacccccca attcctacct 20
<210> 1349
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1349
tggacctcaa ccccctactt 20
<210> 1350
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1350
ccgcctgaat cccccacgcc 20
<210> 1351
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1351
gtgtccaaac tcacaggcta 20
<210> 1352
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1352
gtgcataaca caaatattgc 20
<210> 1353
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1353
accaagatta ccctcaggat 20
<210> 1354
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1354
gcacacccca tctcagtgac 20
<210> 1355
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1355
atgacaccca ttctggacat 20
<210> 1356
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1356
gcaccctccc tctactggca 20
<210> 1357
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1357
tctgctgtcc actcctgaac 20
<210> 1358
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1358
gctgcaattc aacactgcct 20
<210> 1359
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1359
cggaggctgc ccattagctg 20
<210> 1360
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1360
aaacaggtgc attctagggt 20
<210> 1361
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1361
acctggtgca cctggagtca 20
<210> 1362
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1362
gccctgctca gcacgaagcc 20
<210> 1363
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1363
tggacaggcc attcccactc 20
<210> 1364
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1364
gcccacacgc catacagtta 20
<210> 1365
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1365
ggacattccc agcattgacc 20
<210> 1366
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1366
cgaagctcta atccctggcc 20
<210> 1367
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1367
cacaggtaaa agacacgaca 20
<210> 1368
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1368
ggccgtgtcc tcccaagcct 20
<210> 1369
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1369
agtcttagcc accaaggcct 20
<210> 1370
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1370
ggacgggtcc ccatcttgcc 20
<210> 1371
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1371
gtgtttaccc aagacagcta 20
<210> 1372
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1372
cagggaaccc caccacatca 20
<210> 1373
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1373
acacccgtca ccctctgcac 20
<210> 1374
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1374
gtcccaggct tctcttggga 20
<210> 1375
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1375
gtgttctgtt ttacactaat 20
<210> 1376
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1376
gtgagatcca cactccagaa 20
<210> 1377
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1377
tgcccaaaac tacagcggtc 20
<210> 1378
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1378
cgccagggca gaattacctt 20
<210> 1379
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1379
gcaatgccca caaaggtggc 20
<210> 1380
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1380
gcagaagccc ccaactcact 20
<210> 1381
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1381
tcaaagctcc agctacacct 20
<210> 1382
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1382
ttgctcaact ccagagaacc 20
<210> 1383
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1383
ccttaattac ctctaaagaa 20
<210> 1384
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1384
tcccagtgcc tcacacgcgg 20
<210> 1385
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1385
cagctctatc ttcccagaca 20
<210> 1386
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1386
aagcttctcc tctctggaca 20
<210> 1387
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1387
tcacctgttt tactgagcct 20
<210> 1388
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1388
gccaccagct catttcactc 20
<210> 1389
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1389
ccactctacc ctctggcatc 20
<210> 1390
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1390
ggtgggctca ttattagagc 20
<210> 1391
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1391
gcagcatcca aacccacggt 20
<210> 1392
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1392
caacagttct ccctgctgac 20
<210> 1393
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1393
tgcccatcca cccacttgga 20
<210> 1394
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1394
agagggtcca ccccagacag 20
<210> 1395
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1395
agcaggcctc cccattgtcc 20
<210> 1396
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1396
atctgcccag aacctcgcca 20
<210> 1397
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1397
gcagagggtc ccatgaggct 20
<210> 1398
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1398
cctgagcact cttacgcata 20
<210> 1399
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1399
ccccaaagtc tcccccctac 20
<210> 1400
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1400
cacagccacc tcaaagatga 20
<210> 1401
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1401
gcaggacaat ttctaggtac 20
<210> 1402
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1402
ttcccttaac cacctgtgca 20
<210> 1403
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1403
acagtccacc tagatggtcc 20
<210> 1404
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1404
cctgaccgac acctgtccca 20
<210> 1405
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1405
gcacggcccc atctgaactc 20
<210> 1406
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1406
agtccatccc agatgaccca 20
<210> 1407
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1407
gtgagctccc aactctgtcc 20
<210> 1408
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1408
gagcacacgc tcctatgcat 20
<210> 1409
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1409
cagagagact ccacctgtcc 20
<210> 1410
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1410
cccaggcccc atgtgtggtc 20
<210> 1411
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1411
accacagcct agaccaggct 20
<210> 1412
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1412
ctggacagtt caccccagat 20
<210> 1413
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1413
gtcttacttc ttaatggaga 20
<210> 1414
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1414
ggctgaggtt tctacagcca 20
<210> 1415
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1415
aagctcacaa cactcagggt 20
<210> 1416
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1416
atattgccat tttaaccctc 20
<210> 1417
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1417
gcagagtccc accaccaaga 20
<210> 1418
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1418
aggccattcc cactcgctgt 20
<210> 1419
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1419
cccatccacc cacttggaca 20
<210> 1420
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1420
actctgtcca cttcctccac 20
<210> 1421
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1421
gaaagttgcc cactcctgta 20
<210> 1422
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1422
gggttcgccc ttactcatca 20
<210> 1423
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1423
ctgttttaca ctaatgcggg 20
<210> 1424
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1424
gcacccctct cacatgcccg 20
<210> 1425
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1425
aaactctcct cactagcctg 20
<210> 1426
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1426
agtgacactc aaaagtgctc 20
<210> 1427
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1427
ccaaggagac ctcactgctc 20
<210> 1428
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1428
tggctgaccc ccgccagggc 20
<210> 1429
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1429
gatgcgggcc aggctaggcc 20
<210> 1430
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1430
gccactctcc ctccaataga 20
<210> 1431
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1431
agacagtcca ccctggatga 20
<210> 1432
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1432
tctatcttcc cagacacact 20
<210> 1433
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1433
tagtcataca cagatggcca 20
<210> 1434
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1434
cgggtcccca tcttgcctac 20
<210> 1435
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1435
gcaccgggca cagatcccac 20
<210> 1436
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1436
ccgggctccc atgaatgtcc 20
<210> 1437
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1437
gggctttgat atataaatct 20
<210> 1438
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1438
gccaaggaac atcagggcga 20
<210> 1439
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1439
tggccggaac acactttcac 20
<210> 1440
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1440
caggcctccc cattgtccat 20
<210> 1441
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1441
gccctagctt ccccagagca 20
<210> 1442
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1442
caagattacc ctcaggatca 20
<210> 1443
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1443
gtctgagacc catctgggtc 20
<210> 1444
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1444
tctctgccag ccctaactta 20
<210> 1445
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1445
agcacgagta ccctctgcca 20
<210> 1446
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1446
agctgctaaa agaaatgcca 20
<210> 1447
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1447
ctcaaccccc tacttggtct 20
<210> 1448
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1448
acccgtcacc ctctgcacca 20
<210> 1449
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1449
ctcacaggct actcccccca 20
<210> 1450
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1450
ggtcccctcc ttctcccatc 20
<210> 1451
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1451
acgctcctcc agctgagcct 20
<210> 1452
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1452
tgcaattcaa cactgcctta 20
<210> 1453
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1453
tttgaggaaa tctacgggta 20
<210> 1454
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1454
tgaatccccc acgccaggcc 20
<210> 1455
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1455
gctgtaccca caggcggcac 20
<210> 1456
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1456
acaggctcca ttgagaggct 20
<210> 1457
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1457
atgttaaata taaccacccc 20
<210> 1458
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1458
cccgcaccca cctctggtgc 20
<210> 1459
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1459
tggagtggag actcatccca 20
<210> 1460
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1460
actgagttca acaagatgaa 20
<210> 1461
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1461
gccccactca ccatgcagac 20
<210> 1462
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1462
gcggtctctt ctctctgttc 20
<210> 1463
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1463
gatgaattat tcccatgggc 20
<210> 1464
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1464
ccttggcatt cactgagcct 20
<210> 1465
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1465
tcctgacacc ccaccaacgc 20
<210> 1466
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1466
tgctgtccac tcctgaacac 20
<210> 1467
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1467
gtcttgttct ctgcgagaac 20
<210> 1468
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1468
gccacgcaga tcatgatgac 20
<210> 1469
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1469
ctcaaccgcc tcttctgcaa 20
<210> 1470
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1470
cacacggctc ctgtgagtca 20
<210> 1471
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1471
cccaggctca ttcccgccat 20
<210> 1472
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1472
cgaggcagaa ttctccattc 20
<210> 1473
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1473
tctacaggct ccttgcatgc 20
<210> 1474
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1474
gggaacccca ccacatcact 20
<210> 1475
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1475
gctcaactcc agagaaccaa 20
<210> 1476
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1476
accagctcat ttcactccgg 20
<210> 1477
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1477
caacaggttc tacctaccaa 20
<210> 1478
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1478
cgactctgaa cctctgcctc 20
<210> 1479
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1479
agggcagaat taccttgcaa 20
<210> 1480
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1480
tccacactcc agaagaacaa 20
<210> 1481
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1481
tctcatggct ctcattggcc 20
<210> 1482
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1482
cagttatgac tcaatgagcc 20
<210> 1483
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1483
tcctggttcc accatcaaga 20
<210> 1484
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1484
gcaaccctgc ccattgccag 20
<210> 1485
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1485
gggctggaca ccagccgacc 20
<210> 1486
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1486
caccaggcca accatccccc 20
<210> 1487
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1487
cttgccatcc cgaaattcca 20
<210> 1488
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1488
attttaaccc tctttgccgc 20
<210> 1489
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1489
tgcacatccc gatttggccc 20
<210> 1490
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1490
gtgatttgca tccagaattc 20
<210> 1491
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1491
tggtccctgc ccatagaggt 20
<210> 1492
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1492
ctccctccaa tagaacctca 20
<210> 1493
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1493
cactggctgt taaatttgct 20
<210> 1494
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1494
gtccacttcc tccaccgggc 20
<210> 1495
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1495
gtctctgtat atgcctggcc 20
<210> 1496
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1496
gcacagctcc catggatgaa 20
<210> 1497
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1497
ggtcccaggc ctctgagcgc 20
<210> 1498
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1498
ggtgccgaac cttaaggacc 20
<210> 1499
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1499
gcaggtccac cctcccccgc 20
<210> 1500
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1500
taaccgttcc cttccatgtc 20
<210> 1501
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1501
acctcactgc tcacaaggcc 20
<210> 1502
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1502
gccttcgcca tcgccaggct 20
<210> 1503
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1503
gggctcgcca cccctcatgc 20
<210> 1504
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1504
gctaatgaaa cagcctggtc 20
<210> 1505
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1505
cttggtttcc aatcatcatt 20
<210> 1506
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1506
ttggctcacc cagatcatcc 20
<210> 1507
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1507
aaccatggtc ctcctgggcc 20
<210> 1508
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1508
ctcttggttc acacaaccaa 20
<210> 1509
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1509
gggctgccac cctcactgaa 20
<210> 1510
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1510
gcccaagcac ttcacaccct 20
<210> 1511
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1511
gatggtccac actaaatggt 20
<210> 1512
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1512
cactatgcca ctaaggacac 20
<210> 1513
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1513
aggtaagcat ttaaaccttg 20
<210> 1514
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1514
atggaagccc ccttcaaccc 20
<210> 1515
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1515
tctcagggtc tccctggata 20
<210> 1516
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1516
agctcaggcc acccaagact 20
<210> 1517
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1517
tgcggaatcc cctcctgcac 20
<210> 1518
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1518
tctgttcacc tcacatgcat 20
<210> 1519
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1519
gggatggctt ctaatggcag 20
<210> 1520
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1520
cagggtcatc ctcgaagcca 20
<210> 1521
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1521
ccaccaagaa acatcgcaga 20
<210> 1522
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1522
gctccgcttg aatctaaaca 20
<210> 1523
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1523
gtctcccgcc ctgcctggtc 20
<210> 1524
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1524
cctgttggtc cttaactgaa 20
<210> 1525
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1525
accagcacag caaaggcaca 20
<210> 1526
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1526
ctttcactct ccatcgggtt 20
<210> 1527
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1527
gctggcccaa ctctagctga 20
<210> 1528
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1528
cacccttccc aaactcagct 20
<210> 1529
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1529
cacagttcaa tcccgaacac 20
<210> 1530
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1530
gccttgggct cttacccaca 20
<210> 1531
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1531
gctcaaacca tcaggaccca 20
<210> 1532
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1532
tcatttcact ccggcaggca 20
<210> 1533
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1533
ctcgctgtca acacacgaac 20
<210> 1534
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1534
tctgaagccc caaactagct 20
<210> 1535
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1535
gcatcagccc agagcacccc 20
<210> 1536
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1536
tgagctccac ctcatgccga 20
<210> 1537
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1537
ggtcgggcta tctaacccac 20
<210> 1538
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1538
gggtttgtca cacccttcac 20
<210> 1539
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1539
gcatgggaca atctccccca 20
<210> 1540
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1540
aggcagcact cactctacca 20
<210> 1541
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1541
tagagtccca gcacctgcct 20
<210> 1542
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1542
tacagcatta caatttgatc 20
<210> 1543
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1543
cccctctcac atgcccggct 20
<210> 1544
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1544
atggatggtc caccccagac 20
<210> 1545
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1545
aggaaaactc caatgctgcc 20
<210> 1546
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1546
tctgtcccca agctctgccg 20
<210> 1547
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1547
gagctggccc tccccccgca 20
<210> 1548
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1548
ggcctggttt ccctatttac 20
<210> 1549
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1549
cctgatgaaa cttcagccct 20
<210> 1550
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1550
ccagaagaac aaacctacca 20
<210> 1551
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1551
caaagcctct tccatttgac 20
<210> 1552
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1552
tacaaaccag taaggaacca 20
<210> 1553
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1553
tgagctcctc agcatgggcc 20
<210> 1554
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1554
ctggagacac catcttcgga 20
<210> 1555
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1555
tcagccttca ctcacacagt 20
<210> 1556
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1556
agtgggcatc cccatactgc 20
<210> 1557
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1557
ggctcagtgc ccttcaggga 20
<210> 1558
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1558
gctgctcacc ttttctagtt 20
<210> 1559
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1559
aggctactcc ccccaggcct 20
<210> 1560
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1560
gggaagctcc acaccagctc 20
<210> 1561
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1561
agttcctccc cagacaccgt 20
<210> 1562
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1562
catgtagtcc tcctcggcgc 20
<210> 1563
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1563
gcaaagctcc ctctggagga 20
<210> 1564
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1564
cacgataatt tcccatcttc 20
<210> 1565
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1565
tgaccctgcc ttcactgacc 20
<210> 1566
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1566
ggcatcagac cccaccccaa 20
<210> 1567
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1567
aaagcaggtc cccctgcacc 20
<210> 1568
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1568
ctgatgaaac ttcagccctc 20
<210> 1569
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1569
cgagaaggcc ctcttcttcc 20
<210> 1570
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1570
ggctcgccac ccctcatgca 20
<210> 1571
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1571
cactaaggac acattcaggc 20
<210> 1572
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1572
actggctgtt aaatttgcta 20
<210> 1573
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1573
aaccgttccc ttccatgtca 20
<210> 1574
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1574
ggctactccc cccaggcctc 20
<210> 1575
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1575
ccttcactca cacagtggcc 20
<210> 1576
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1576
ggcatctgtc ccacatggac 20
<210> 1577
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1577
ggtacggcct catccaggtc 20
<210> 1578
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1578
gtttgtcaca cccttcactt 20
<210> 1579
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1579
tccaatagaa cctcactgta 20
<210> 1580
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1580
gcggaatccc ctcctgcaca 20
<210> 1581
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1581
ggagtggaga ctcatcccac 20
<210> 1582
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1582
aggtccaccc tcccccgcaa 20
<210> 1583
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1583
agcatttaaa ccttggtgga 20
<210> 1584
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1584
cttggttcac acaaccaaat 20
<210> 1585
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1585
gtcgggctat ctaacccaca 20
<210> 1586
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1586
ctaatgaaac agcctggtca 20
<210> 1587
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1587
ctgttggtcc ttaactgaaa 20
<210> 1588
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1588
ccaagcactt cacaccctga 20
<210> 1589
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1589
aaagcctctt ccatttgacc 20
<210> 1590
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1590
ccggcaggca cagactggcc 20
<210> 1591
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1591
caccaagaaa catcgcagac 20
<210> 1592
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1592
tggaagcccc cttcaaccct 20
<210> 1593
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1593
gcacatgtcc ccctaaacgg 20
<210> 1594
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1594
acagcattac aatttgatca 20
<210> 1595
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1595
agcaaaggca caacaagatc 20
<210> 1596
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1596
ctgaagcccc aaactagctg 20
<210> 1597
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1597
ccctctcaca tgcccggctt 20
<210> 1598
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1598
ccttcccaaa ctcagctcca 20
<210> 1599
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1599
tcgctgtcaa cacacgaaca 20
<210> 1600
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1600
cagaagaaca aacctaccaa 20
<210> 1601
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1601
ctgagaggac tcagggactt 20
<210> 1602
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1602
ttgccatccc gaaattccaa 20
<210> 1603
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1603
agctggccct ccccccgcat 20
<210> 1604
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1604
ctttgaggcc ccttgacctc 20
<210> 1605
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1605
gagcggctat cccgctgccc 20
<210> 1606
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1606
aggctgtccc cttgtctcca 20
<210> 1607
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1607
ggcttgtcac cccaccgggc 20
<210> 1608
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1608
ggatggtcca ccccagacga 20
<210> 1609
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1609
gggcccacca tagccctgca 20
<210> 1610
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1610
gtgccgaacc ttaaggaccc 20
<210> 1611
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1611
gcctggtttc cctatttact 20
<210> 1612
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1612
atccagaatt ccagccgtac 20
<210> 1613
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1613
gtgggcatcc ccatactgcc 20
<210> 1614
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1614
tggccagctc ctcttgtctt 20
<210> 1615
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1615
tggagacacc atcttcggaa 20
<210> 1616
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1616
cgcttgagtc ataaagacgc 20
<210> 1617
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1617
caggcacccc actcactcga 20
<210> 1618
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1618
ggcagcactc actctaccac 20
<210> 1619
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1619
cttcgactca ccgtggctcc 20
<210> 1620
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1620
agctcctcag catgggcccc 20
<210> 1621
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1621
ccttgggctc ttacccacat 20
<210> 1622
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1622
ttttaaccct ctttgccgcc 20
<210> 1623
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1623
catgggacaa tctcccccaa 20
<210> 1624
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1624
catgcatgcc ttcatctaca 20
<210> 1625
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1625
accaggccaa ccatccccca 20
<210> 1626
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1626
gaggaagctc caatccaggt 20
<210> 1627
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1627
gaaccagcag caaaggacgc 20
<210> 1628
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1628
ttggtttcca atcatcattt 20
<210> 1629
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1629
caatcccgaa caccatgtca 20
<210> 1630
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1630
gcccaactct agctgatgcc 20
<210> 1631
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1631
gcagctcccc agccccagaa 20
<210> 1632
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1632
atggtccaca ctaaatggtc 20
<210> 1633
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1633
gccggagcca cctcctgcct 20
<210> 1634
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1634
gcagctcatc cctccgagaa 20
<210> 1635
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1635
ccacaggcca ccttgaggtg 20
<210> 1636
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1636
gccccccacc ttccagatct 20
<210> 1637
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1637
ccacggtgtc acaatcctgc 20
<210> 1638
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1638
gccgagctct tctctgtcca 20
<210> 1639
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1639
gggctatcta acccacagcc 20
<210> 1640
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1640
agcactcact ctaccacgga 20
<210> 1641
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1641
gcacttcaca ccctgaggca 20
<210> 1642
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1642
tcccgaaatt ccaaatcctc 20
<210> 1643
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1643
aggcacccca ctcactcgat 20
<210> 1644
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1644
gcttgagtca taaagacgca 20
<210> 1645
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1645
ccatcaggcc atctttgaca 20
<210> 1646
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1646
gatctgagcc cctcggtcca 20
<210> 1647
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1647
gcatggttcc ccgactcctc 20
<210> 1648
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1648
agtggagact catcccaccc 20
<210> 1649
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1649
gacttagccc catcagggcc 20
<210> 1650
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1650
cctggtttcc ctatttactg 20
<210> 1651
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1651
gcccatctcc ccatgcttgt 20
<210> 1652
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1652
ccccttgacc tcctcctggc 20
<210> 1653
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1653
cacatgtccc cctaaacggc 20
<210> 1654
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1654
tctccgcttc ctgtcagggc 20
<210> 1655
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1655
cggaaggaca ttcagagaaa 20
<210> 1656
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1656
ccgttccctt ccatgtcaca 20
<210> 1657
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1657
gtgaaattcc agaacaactt 20
<210> 1658
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1658
ggatgcggcc cactccccac 20
<210> 1659
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1659
gctcttctct gtccaaggcc 20
<210> 1660
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1660
ggcacaacaa gatccaggca 20
<210> 1661
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1661
ctcgccaccc ctcatgcata 20
<210> 1662
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1662
gaagaacaaa cctaccaagt 20
<210> 1663
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1663
ttgccggccc ttctgtggat 20
<210> 1664
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1664
cagctcatcc ctccgagaac 20
<210> 1665
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1665
gtcaacacac gaacagaacc 20
<210> 1666
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1666
actcagggac ttgccaagca 20
<210> 1667
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1667
tctttgccgc cctcttttaa 20
<210> 1668
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1668
cctggttttc ccccacggaa 20
<210> 1669
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1669
tttgtcacac ccttcacttt 20
<210> 1670
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1670
ggaagccccc ttcaaccctc 20
<210> 1671
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1671
gcatctgtcc cacatggacc 20
<210> 1672
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1672
gctagggatc ccaatgaaat 20
<210> 1673
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1673
aagcaggtcc ccctgcacct 20
<210> 1674
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1674
cgccgcccgg gatctcgcct 20
<210> 1675
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1675
tggtccacac taaatggtcc 20
<210> 1676
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1676
caggagggtc ctccaagcgg 20
<210> 1677
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1677
ggacaagctc cctcattgaa 20
<210> 1678
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1678
cttgtcaccc caccgggcat 20
<210> 1679
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1679
ctggctgtta aatttgctac 20
<210> 1680
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1680
gacctggaca caccaccctc 20
<210> 1681
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1681
gaggagggca cttatgcaat 20
<210> 1682
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1682
gcttcaggcc cactgccaac 20
<210> 1683
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1683
gtcttttctt tcaactgatc 20
<210> 1684
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1684
ctggccctcc ccccgcatga 20
<210> 1685
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1685
ggtttccaat catcattttc 20
<210> 1686
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1686
cttcactcac acagtggccg 20
<210> 1687
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1687
ccgtgtgccc ttaccgtagc 20
<210> 1688
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1688
aagcctcttc catttgacct 20
<210> 1689
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1689
gcttccccac caccagtgca 20
<210> 1690
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1690
cttgggctct tacccacata 20
<210> 1691
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1691
ggcatcccca tactgccccc 20
<210> 1692
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1692
aaggcggcca ctcccttccc 20
<210> 1693
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1693
acaatttgat caaccacagc 20
<210> 1694
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1694
caatagaacc tcactgtata 20
<210> 1695
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1695
agaaggccct cttcttccgc 20
<210> 1696
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1696
gacaatctcc cccaaagcgg 20
<210> 1697
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1697
cacggtgtca caatcctgca 20
<210> 1698
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1698
taaggacaca ttcaggctcc 20
<210> 1699
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1699
atcgcagacc cacctgccac 20
<210> 1700
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1700
acgataattt cccatcttca 20
<210> 1701
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1701
ccaggatccc agcataagac 20
<210> 1702
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1702
ggtggagtaa aaacaatgat 20
<210> 1703
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1703
ggtacagcct gaaactggcc 20
<210> 1704
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1704
cggagccacc tcctgcctga 20
<210> 1705
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1705
gatggtccac cccagacgat 20
<210> 1706
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1706
agctaagtcc cctccctgtc 20
<210> 1707
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1707
ccaggccaac catcccccac 20
<210> 1708
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1708
gttcacacaa ccaaatgtta 20
<210> 1709
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1709
tgcatgcctt catctacacc 20
<210> 1710
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1710
gtctcagatt cacaatcccg 20
<210> 1711
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1711
cggcaggcac agactggccc 20
<210> 1712
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1712
gctcagggcc tcctgatgca 20
<210> 1713
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1713
atgcccggct tccccgggcc 20
<210> 1714
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1714
gaggaccccc tttcttgctg 20
<210> 1715
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1715
caccgtcacc ctcccgggca 20
<210> 1716
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1716
catggttccc cgactcctcc 20
<210> 1717
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1717
ttccatgtca cagacgcggc 20
<210> 1718
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1718
aggcggccac tcccttccca 20
<210> 1719
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1719
gccaacccct ccacttccga 20
<210> 1720
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1720
atggtgagta gagtgtgcca 20
<210> 1721
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1721
gcggctgatc ccctcctcca 20
<210> 1722
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1722
gcatgccttc atctacacct 20
<210> 1723
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1723
caggtgaaca cagtcagctc 20
<210> 1724
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1724
acttagcccc atcagggcct 20
<210> 1725
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1725
gcctccacct ttcccactga 20
<210> 1726
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1726
ctggtttccc tatttactga 20
<210> 1727
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1727
gtctcttgcc ctgacaggcc 20
<210> 1728
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1728
tcacggaccc tcctccatgc 20
<210> 1729
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1729
agggatccca atgaaataca 20
<210> 1730
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1730
gggacaagcc tcccacagac 20
<210> 1731
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1731
caggatccca gcataagact 20
<210> 1732
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1732
cccgaaattc caaatcctcc 20
<210> 1733
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1733
gaggatttcc cacgacatct 20
<210> 1734
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1734
cgtctgctcc tatcagtcgg 20
<210> 1735
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1735
cggcgaattc cccggagcct 20
<210> 1736
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1736
tcgccacccc tcatgcatac 20
<210> 1737
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1737
caggccaacc atcccccacc 20
<210> 1738
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1738
agcctcttcc atttgaccta 20
<210> 1739
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1739
tggagactca tcccacccca 20
<210> 1740
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1740
gccctgtccc cccattgggc 20
<210> 1741
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1741
gggctaggaa gaacctgcct 20
<210> 1742
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1742
acactgtgat ccaaaatgaa 20
<210> 1743
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1743
gtttgtgaat caccataacc 20
<210> 1744
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1744
gtcacaccct tcactttgtc 20
<210> 1745
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1745
aacaaaccta ccaagtcctc 20
<210> 1746
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1746
catcaggcca tctttgacac 20
<210> 1747
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1747
aatggtccat cccagaaggt 20
<210> 1748
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1748
caacagcctt ctctgagccg 20
<210> 1749
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1749
cggtgtcaca atcctgcagc 20
<210> 1750
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1750
ggcagggcca cctcgcccct 20
<210> 1751
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1751
tggacacacc accctccacc 20
<210> 1752
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1752
gagtcggtca ccagaaaggc 20
<210> 1753
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1753
tgcccggctt ccccgggccc 20
<210> 1754
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1754
ttgggctctt acccacatac 20
<210> 1755
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1755
gaaggccctc ttcttccgct 20
<210> 1756
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1756
cacttatgca atcccaggct 20
<210> 1757
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1757
gacaagctcc ctcattgaat 20
<210> 1758
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1758
agctcatccc tccgagaaca 20
<210> 1759
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1759
ggcaccccac tcactcgatc 20
<210> 1760
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1760
gtacagcctg aaactggcca 20
<210> 1761
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1761
gctaagtccc ctccctgtcc 20
<210> 1762
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1762
cggccacgcc ttacttgtcc 20
<210> 1763
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1763
cactgtatac ttcatttcca 20
<210> 1764
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1764
gggctggtcc ccaaagacat 20
<210> 1765
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1765
accgtcaccc tcccgggcat 20
<210> 1766
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1766
cacacgaaca gaacctgcac 20
<210> 1767
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1767
gacatgtgcc cacaccaggc 20
<210> 1768
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1768
ggctatctaa cccacagccc 20
<210> 1769
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1769
taatttccca tcttcaaggc 20
<210> 1770
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1770
cagggacttg ccaagcagtc 20
<210> 1771
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1771
ctggttttcc cccacggaac 20
<210> 1772
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1772
ggacacttcc actggaggat 20
<210> 1773
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1773
cgtgtgccct taccgtagcc 20
<210> 1774
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1774
cccctcggtc cagaatggcc 20
<210> 1775
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1775
gttcagttcc ctgctgcctc 20
<210> 1776
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1776
ccgccctctt ttaaggactt 20
<210> 1777
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1777
ttgctgagaa gatcctctct 20
<210> 1778
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1778
cccttgacct cctcctggca 20
<210> 1779
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1779
ttcacacaac caaatgttat 20
<210> 1780
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1780
tcgcagaccc acctgccacc 20
<210> 1781
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1781
aggatgagtc ctcatttgca 20
<210> 1782
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1782
aatttgatca accacagcca 20
<210> 1783
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1783
caactgatcc actttcccct 20
<210> 1784
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1784
catctgtccc acatggaccc 20
<210> 1785
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1785
ttcaggccca ctgccaaccc 20
<210> 1786
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1786
caggaaacaa gaaccacgac 20
<210> 1787
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1787
ggagtgtccc agaaagtgca 20
<210> 1788
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1788
cccaacccac atcacagtgt 20
<210> 1789
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1789
gaagccccct tcaaccctcc 20
<210> 1790
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1790
gctgtggtga ctcactgcca 20
<210> 1791
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1791
tccaccccag acgatccacc 20
<210> 1792
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1792
ggttcattcc agactggagc 20
<210> 1793
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1793
ccctgtcccc ccattgggca 20
<210> 1794
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1794
aggatttccc acgacatctt 20
<210> 1795
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1795
ggttttcccc cacggaaccc 20
<210> 1796
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1796
tcagtcggct gccttagccc 20
<210> 1797
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1797
aggccaacca tcccccacca 20
<210> 1798
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1798
gccggctgtc caccttgacc 20
<210> 1799
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1799
ttgttgcaaa ctaagtgccc 20
<210> 1800
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1800
ccagacagtc catcctagat 20
<210> 1801
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1801
tccatttgac ctacatctta 20
<210> 1802
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1802
ccaaagacat gactcaggac 20
<210> 1803
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1803
gcaccccact cactcgatct 20
<210> 1804
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1804
tccctgtccc atcctataga 20
<210> 1805
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1805
ttgacacggg caaccaggac 20
<210> 1806
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1806
gaggagcttc aatctatgcc 20
<210> 1807
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1807
ggtctggccc tctaccccca 20
<210> 1808
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1808
ggagcctgcc ctactcatct 20
<210> 1809
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1809
tgtgaatcac cataaccaga 20
<210> 1810
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1810
cagggatctg tctctatttc 20
<210> 1811
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1811
gtggctggaa catctccggt 20
<210> 1812
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1812
agtcggtcac cagaaaggca 20
<210> 1813
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1813
ggacaagcct cccacagacc 20
<210> 1814
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1814
ggtgtcacaa tcctgcagcc 20
<210> 1815
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1815
tgctgcctcc agtcacttca 20
<210> 1816
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1816
acagcccccc catcatctca 20
<210> 1817
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1817
atttgatcaa ccacagccac 20
<210> 1818
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1818
gttccccgac tcctcctcga 20
<210> 1819
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1819
tctggtagaa tattccattc 20
<210> 1820
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1820
gctatctaac ccacagcccc 20
<210> 1821
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1821
ggtagggccc tcactgctgc 20
<210> 1822
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1822
acttatgcaa tcccaggctc 20
<210> 1823
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1823
ggccgacaca tccgtgggac 20
<210> 1824
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1824
ggctgcacta acccaggaca 20
<210> 1825
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1825
caccccagac gatccacccc 20
<210> 1826
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1826
aaggccctct tcttccgctt 20
<210> 1827
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1827
ccttgacctc ctcctggcac 20
<210> 1828
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1828
gctgagaaga tcctctctct 20
<210> 1829
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1829
cacacagaac caccaggtcc 20
<210> 1830
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1830
tgactcctcc acccagaccc 20
<210> 1831
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1831
gggccagcta ttctgagcct 20
<210> 1832
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1832
cccgtgtgtc ctcacagtcc 20
<210> 1833
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1833
ccctcggtcc agaatggcct 20
<210> 1834
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1834
cgactgagat tctaacgcga 20
<210> 1835
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1835
gttttgggcc aggatggcct 20
<210> 1836
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1836
cccggcttcc ccgggccctt 20
<210> 1837
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1837
aacaagaacc acgacagggc 20
<210> 1838
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1838
tcccaatgaa atacatgaca 20
<210> 1839
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1839
cccttcaacc ctcctgtgga 20
<210> 1840
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1840
gccgagccca ggaaatgcct 20
<210> 1841
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1841
gagtgtccca gaaagtgcac 20
<210> 1842
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1842
cagttgtccc agactggcca 20
<210> 1843
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1843
gtcagcatcc tgatttccct 20
<210> 1844
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1844
acaagctccc tcattgaata 20
<210> 1845
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1845
agggacttgc caagcagtcc 20
<210> 1846
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1846
tgggctctta cccacatact 20
<210> 1847
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1847
gagtttggac cccctaggtc 20
<210> 1848
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1848
tgtggactca ccagttgatc 20
<210> 1849
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1849
cgcagaccca cctgccacca 20
<210> 1850
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1850
gccagaggct ctactcccgg 20
<210> 1851
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1851
ccaacccaca tcacagtgtc 20
<210> 1852
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1852
ccgaaattcc aaatcctcct 20
<210> 1853
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1853
cggccactcc cttcccaggt 20
<210> 1854
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1854
gcagaagaat ctacttcctg 20
<210> 1855
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1855
agaacctgca cccgaagccg 20
<210> 1856
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1856
aatttcccat cttcaaggcc 20
<210> 1857
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1857
gtagaagcct caactagttt 20
<210> 1858
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1858
tcacaccctt cactttgtcc 20
<210> 1859
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1859
ccaacccctc cacttccgat 20
<210> 1860
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1860
ctgtatactt catttccaac 20
<210> 1861
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1861
ggatgagtcc tcatttgcaa 20
<210> 1862
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1862
acggaccctc ctccatgccc 20
<210> 1863
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1863
atctgtccca catggacccc 20
<210> 1864
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1864
cgagccccca cagccatggc 20
<210> 1865
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1865
acagagccct ccatgtagta 20
<210> 1866
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1866
gtctgattca tcctcatttc 20
<210> 1867
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1867
gtttccctat ttactgagcc 20
<210> 1868
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1868
gccttcatct acacctgcac 20
<210> 1869
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1869
ccgtgtgtcc tcacagtcct 20
<210> 1870
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1870
ccttcatcta cacctgcaca 20
<210> 1871
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1871
gcctccagtc acttcacctc 20
<210> 1872
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1872
tttgatcaac cacagccaca 20
<210> 1873
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1873
ctgagaagat cctctctctc 20
<210> 1874
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1874
cccaccctgc ttcaaggcct 20
<210> 1875
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1875
tggacatcca tctatcatcc 20
<210> 1876
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1876
gctgagagga ctcagggact 20
<210> 1877
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1877
cctcactccc gcccttgcct 20
<210> 1878
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1878
ggatctgtct ctatttcttc 20
<210> 1879
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1879
cacatggacc ccagcaccat 20
<210> 1880
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1880
cccaatgaaa tacatgacac 20
<210> 1881
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1881
cagccccccc atcatctcac 20
<210> 1882
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1882
cagttgctcc ttccttgcca 20
<210> 1883
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1883
gctgcactaa cccaggacaa 20
<210> 1884
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1884
tgccctgtac cccatgggcc 20
<210> 1885
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1885
aaagggcaca cacatgtctc 20
<210> 1886
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1886
tgacagttca ctccagatga 20
<210> 1887
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1887
ccagatgcta tcctcatgga 20
<210> 1888
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1888
atcctgattt ccctcattgt 20
<210> 1889
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1889
gtggagtgcc ccagaacggc 20
<210> 1890
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1890
cccacggaac ccctctcagc 20
<210> 1891
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1891
tttccctatt tactgagcct 20
<210> 1892
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1892
tggctggaac atctccggtt 20
<210> 1893
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1893
ggccactccc ttcccaggtg 20
<210> 1894
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1894
atttcccatc ttcaaggccc 20
<210> 1895
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1895
tcttgttgtc ctcccgcttc 20
<210> 1896
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1896
aaatcctcct gataatcctc 20
<210> 1897
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1897
aggtgatgcc ccacaagaca 20
<210> 1898
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1898
ccagacgatc caccccagat 20
<210> 1899
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1899
agaatattcc attccccgca 20
<210> 1900
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1900
cccactgcaa catctttccc 20
<210> 1901
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1901
gtgaatcacc ataaccagac 20
<210> 1902
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1902
gagctcctca gcatgggccc 20
<210> 1903
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1903
gactcctcca cccagaccct 20
<210> 1904
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1904
agaatctact tcctgtgtcc 20
<210> 1905
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1905
gagtgtgcca tccccagggt 20
<210> 1906
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1906
cacagtgtcc cccacgggca 20
<210> 1907
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1907
gtgagctgaa atatcatgcc 20
<210> 1908
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1908
ctatctaacc cacagccccc 20
<210> 1909
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1909
gacgcaggca tcccactcat 20
<210> 1910
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1910
ccctggcccc tctagcacca 20
<210> 1911
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1911
agctccctca ttgaataatt 20
<210> 1912
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1912
ccggctgtcc accttgaccc 20
<210> 1913
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1913
ttcccacgac atcttttgca 20
<210> 1914
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1914
ccattgggca cttttactca 20
<210> 1915
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1915
ggcaccccag aaacaagagc 20
<210> 1916
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1916
gtgcaccgac acattctgga 20
<210> 1917
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1917
ttccccgggc cctttgctgc 20
<210> 1918
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1918
gtgtcacaat cctgcagcca 20
<210> 1919
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1919
gacaagcctc ccacagacca 20
<210> 1920
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1920
tccccgactc ctcctcgaac 20
<210> 1921
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1921
cctcggccca atctgaactt 20
<210> 1922
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1922
ttgagccgct ccttgaaggt 20
<210> 1923
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1923
cctgccctac tcatctcagc 20
<210> 1924
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1924
tcaggacctt ccagagattt 20
<210> 1925
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1925
cctgtcccat cctatagaca 20
<210> 1926
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1926
aggagcttca atctatgcct 20
<210> 1927
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1927
agggatgatt ctagaaggcc 20
<210> 1928
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1928
ccatttcatt tccaggctta 20
<210> 1929
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1929
ttcatcctca tttcccccgc 20
<210> 1930
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1930
ccgaagccgt cacctccctc 20
<210> 1931
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1931
gggctcaccc ctcacctggt 20
<210> 1932
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1932
ggccaaccat cccccaccaa 20
<210> 1933
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1933
tccccaagca ccacatgacc 20
<210> 1934
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1934
aatggcctca ccttgagatc 20
<210> 1935
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1935
tgctcgctca cagcctgcca 20
<210> 1936
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1936
ccaggtggtt cctcctgcca 20
<210> 1937
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1937
aggcttctcc atgtgaagct 20
<210> 1938
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1938
atttgaccta catcttagct 20
<210> 1939
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1939
ggctcttacc cacatacttg 20
<210> 1940
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1940
caacccctcc acttccgatt 20
<210> 1941
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1941
gacatgactc aggacaggcc 20
<210> 1942
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1942
agtttggacc ccctaggtcc 20
<210> 1943
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1943
ctgagattct aacgcgagcc 20
<210> 1944
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1944
cctgaggcca cacgcagaca 20
<210> 1945
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1945
aaggtggttg caacctgcac 20
<210> 1946
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1946
tgctgatgtc ccctgggacc 20
<210> 1947
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1947
gtccctgtca cacaactgcc 20
<210> 1948
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1948
aggtggttcc tcctgccaga 20
<210> 1949
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1949
gagtttgtcc ccagtgctca 20
<210> 1950
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1950
gggcctccta ctcacccacc 20
<210> 1951
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1951
gcctaggacc ccctgacagc 20
<210> 1952
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1952
tgctccttcc ttgccaagct 20
<210> 1953
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1953
tgccctactc atctcagcgc 20
<210> 1954
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1954
accttgagat cctcaactaa 20
<210> 1955
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1955
gcctggttat gaaatgcgca 20
<210> 1956
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1956
tgagattcta acgcgagccg 20
<210> 1957
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1957
cctgcagatt cacctctgta 20
<210> 1958
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1958
gcaacatctt tccctcactc 20
<210> 1959
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1959
tgttttgaca cccttgggcc 20
<210> 1960
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1960
acctcaggct cctgtaccct 20
<210> 1961
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1961
cagatgctat cctcatggat 20
<210> 1962
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1962
ctggagagga cccacagcca 20
<210> 1963
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1963
gccctggtca ccgacagcct 20
<210> 1964
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1964
cacgcaggtc ccagcagctc 20
<210> 1965
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1965
agttcactcc agatgatcca 20
<210> 1966
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1966
atgggccccc tgcccagtgc 20
<210> 1967
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1967
acggagtccc aggaaaacaa 20
<210> 1968
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1968
tgcaccgaca cattctggaa 20
<210> 1969
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1969
ccacggaacc cctctcagca 20
<210> 1970
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1970
cgatccaccc cagatggtcc 20
<210> 1971
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1971
ttgaataatt aatcaaggac 20
<210> 1972
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1972
cctcatccat aaacaggcag 20
<210> 1973
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1973
tcaccgcgcc atgactgcac 20
<210> 1974
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1974
aaggagagtc ccccttttta 20
<210> 1975
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1975
gcaggcatcc cactcatgaa 20
<210> 1976
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1976
ccccccatca tctcacagtc 20
<210> 1977
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1977
agagtgcccc atcatgccct 20
<210> 1978
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1978
gcactaaccc aggacaacaa 20
<210> 1979
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1979
cccaagcacc acatgaccca 20
<210> 1980
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1980
ctgatttccc tcattgttgc 20
<210> 1981
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1981
ggagcttcaa tctatgcctc 20
<210> 1982
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1982
ttcccggtcc tctacaggtc 20
<210> 1983
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1983
tgaatcacca taaccagacc 20
<210> 1984
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1984
ccccgactcc tcctcgaacc 20
<210> 1985
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1985
tttgacctac atcttagctg 20
<210> 1986
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1986
ccacccagac cctccgacct 20
<210> 1987
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1987
ttccagagat ttcctcctgc 20
<210> 1988
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1988
gaagccgtca cctccctccc 20
<210> 1989
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1989
acagtgtccc ccacgggcat 20
<210> 1990
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1990
ctagaaggcc ctcagcacac 20
<210> 1991
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1991
cacgcagaca ccaagggcac 20
<210> 1992
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1992
cggctgtcca ccttgaccct 20
<210> 1993
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1993
ctgtcccatc ctatagacac 20
<210> 1994
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1994
ctgtgtccat tctcatccac 20
<210> 1995
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1995
ccttcactga ctatgtgcct 20
<210> 1996
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1996
atcgagtcat ctgggagccc 20
<210> 1997
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1997
gcacggaaca tgcttagggc 20
<210> 1998
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1998
tgagaggact cagggacttg 20
<210> 1999
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1999
cccacctgca cagatggcac 20
<210> 2000
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2000
gtgtgccatc cccagggtca 20
<210> 2001
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2001
ctccacttcc gattctgtcc 20
<210> 2002
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2002
gagaagatcc tctctctcca 20
<210> 2003
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2003
ccaatgaaat acatgacaca 20
<210> 2004
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2004
cttcaaggcc ctccacttaa 20
<210> 2005
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2005
gcacacgcca tacctgggca 20
<210> 2006
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2006
ggctcacccc tcacctggtc 20
<210> 2007
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2007
ccctaggtcc cttctcggat 20
<210> 2008
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2008
cctccagtca cttcacctct 20
<210> 2009
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2009
ttgggcactt ttactcaaaa 20
<210> 2010
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2010
tcatcctcat ttcccccgca 20
<210> 2011
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2011
cctgactgac ttcttccaac 20
<210> 2012
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2012
gctcttaccc acatacttgt 20
<210> 2013
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2013
tcccacgaca tcttttgcag 20
<210> 2014
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2014
tcagaagcac ccagaagccg 20
<210> 2015
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2015
gttttaagac ccccttttta 20
<210> 2016
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2016
tggatcagac acccatgccg 20
<210> 2017
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2017
ggacgaagct tcctcttgcc 20
<210> 2018
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2018
ggacatccat ctatcatcca 20
<210> 2019
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2019
tgtgtcctca cagtcctcca 20
<210> 2020
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2020
tgataatcct ctcctccccc 20
<210> 2021
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2021
tccccgggcc ctttgctgct 20
<210> 2022
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2022
acccgcttcc ctcacagagc 20
<210> 2023
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2023
ctcagggact tgccaagcag 20
<210> 2024
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2024
ctagctagca cacacagcca 20
<210> 2025
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2025
cccagaccct ccgaccttta 20
<210> 2026
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2026
gggctgcccg tattcttcct 20
<210> 2027
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2027
ggtggttcct cctgccagac 20
<210> 2028
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2028
gtatggtcca cctaaatggt 20
<210> 2029
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2029
ggaggctgaa ttgtgcttca 20
<210> 2030
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2030
acccaggaca acaaacaagc 20
<210> 2031
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2031
gagcttcaat ctatgcctca 20
<210> 2032
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2032
acgcctctcc tctgtgtgcc 20
<210> 2033
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2033
gccctactca tctcagcgcg 20
<210> 2034
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2034
cctctggaaa gaatgtgcct 20
<210> 2035
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2035
ggtccgagca tcagaatcaa 20
<210> 2036
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2036
gatgctatcc tcatggatgc 20
<210> 2037
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2037
gccctcagca caccgagtca 20
<210> 2038
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2038
ggcgggatca tcctctgcca 20
<210> 2039
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2039
agagtaggtc ccagcagccg 20
<210> 2040
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2040
tgtgtccatt ctcatccact 20
<210> 2041
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2041
agggtcacgc tagtgccacc 20
<210> 2042
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2042
gccccaggca ccattaggcg 20
<210> 2043
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2043
gcaccgacac attctggaaa 20
<210> 2044
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2044
ttgacctaca tcttagctga 20
<210> 2045
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2045
gccagagaca ttaatgaagc 20
<210> 2046
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2046
accagagcca tcagcaggtc 20
<210> 2047
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2047
ccccgggccc tttgctgctt 20
<210> 2048
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2048
gaaagaccca tccccagaga 20
<210> 2049
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2049
tggaccagct cctcctcaaa 20
<210> 2050
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2050
gtgctgtccc agcttgagca 20
<210> 2051
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2051
ccgattctgt cctccagggc 20
<210> 2052
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2052
tctggaagac tccgcagctc 20
<210> 2053
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2053
cgactcctcc tcgaaccttc 20
<210> 2054
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2054
tctgccgtcc cctccagcac 20
<210> 2055
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2055
tccctgtcac acaactgcca 20
<210> 2056
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2056
gtcccatcct atagacacca 20
<210> 2057
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2057
cccacgacat cttttgcagc 20
<210> 2058
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2058
cccccatcat ctcacagtct 20
<210> 2059
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2059
cctgacccca ccactgaagc 20
<210> 2060
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2060
cccaggaccc ccccatggtc 20
<210> 2061
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2061
gcgagggcca caacacagta 20
<210> 2062
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2062
gttttgacac ccttgggcct 20
<210> 2063
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2063
ggtcccctac ttactaagcc 20
<210> 2064
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2064
aggatgcatt ccatccagat 20
<210> 2065
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2065
tgcagattca cctctgtatt 20
<210> 2066
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2066
accgacagcc tctgtggccc 20
<210> 2067
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2067
atacatgaca cacctggtga 20
<210> 2068
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2068
agaccccctt tttacaaatc 20
<210> 2069
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2069
gactgacttc ttccaacttt 20
<210> 2070
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2070
ggcatcccac tcatgaaggc 20
<210> 2071
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2071
gcaccggcaa cttcaggtac 20
<210> 2072
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2072
gtctcagccc tgcttagggc 20
<210> 2073
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2073
accccacccc acatggtggt 20
<210> 2074
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2074
cccaaactca caccagaagc 20
<210> 2075
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2075
acaggtctta atctctggac 20
<210> 2076
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2076
caaggccctc cacttaatca 20
<210> 2077
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2077
ggatcagaca cccatgccgg 20
<210> 2078
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2078
ctcttaccca catacttgtc 20
<210> 2079
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2079
gcggctcgct cacattccct 20
<210> 2080
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2080
gacgaagctt cctcttgcct 20
<210> 2081
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2081
caccataacc agacccggca 20
<210> 2082
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2082
gcaatggacc cactgagttt 20
<210> 2083
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2083
ggatggccca ccccagacaa 20
<210> 2084
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2084
ccagagattt cctcctgctt 20
<210> 2085
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2085
gcacagtgtc ttccagggcc 20
<210> 2086
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2086
aacatctttc cctcactcgc 20
<210> 2087
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2087
ctccagtcac ttcacctctt 20
<210> 2088
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2088
cgtgcaacat tttcaagcct 20
<210> 2089
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2089
gctaaccccc acatcagagc 20
<210> 2090
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2090
cccgcttccc tcacagagcc 20
<210> 2091
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2091
gagagtcccc ctttttagga 20
<210> 2092
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2092
caccacatga cccacaggca 20
<210> 2093
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2093
acgggcatcc ttgtgtgccc 20
<210> 2094
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2094
cacggaaccc ctctcagcac 20
<210> 2095
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2095
cttgagatcc tcaactaatc 20
<210> 2096
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2096
gctgtccacc ttgacccttc 20
<210> 2097
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2097
cattgttgcc cacccattcc 20
<210> 2098
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2098
accatctgct catcatccat 20
<210> 2099
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2099
atcctcattt cccccgcagc 20
<210> 2100
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2100
ctgctcatca tccatccact 20
<210> 2101
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2101
ggtcacgcta gtgccaccgt 20
<210> 2102
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2102
tgaattgtgc ttcacaagtc 20
<210> 2103
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2103
ccaggactgt tcactgctct 20
<210> 2104
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2104
gtgcaacatt ttcaagcctc 20
<210> 2105
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2105
accccctttt tacaaatctt 20
<210> 2106
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2106
cgagcatcag aatcaataac 20
<210> 2107
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2107
cgggagccac agtctccaca 20
<210> 2108
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2108
gatgtttctt ccctctgacc 20
<210> 2109
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2109
acggaacccc tctcagcaca 20
<210> 2110
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2110
aggagcctca cttgttgtcc 20
<210> 2111
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2111
ggatgcattc catccagata 20
<210> 2112
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2112
cctcctcgaa ccttcacggc 20
<210> 2113
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2113
ttttccggca tttctgcttt 20
<210> 2114
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2114
gccttttcta agaaaactcc 20
<210> 2115
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2115
accttgaccc ttccctgcac 20
<210> 2116
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2116
gagatcctca actaatcaca 20
<210> 2117
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2117
ccccaggcac cattaggcgg 20
<210> 2118
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2118
tcttacccac atacttgtcc 20
<210> 2119
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2119
cgaagcttcc tcttgcctgc 20
<210> 2120
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2120
gaccctccga cctttactcc 20
<210> 2121
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2121
gcagggctgt tcctagagac 20
<210> 2122
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2122
cttgtgtgcc ctccaccagc 20
<210> 2123
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2123
ggcaggtcag catcacagac 20
<210> 2124
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2124
aaggccctcc acttaatcat 20
<210> 2125
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2125
gaggagagat cacacaggct 20
<210> 2126
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2126
ctgaattgca cccccagatt 20
<210> 2127
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2127
gaggcgagct ttacactttt 20
<210> 2128
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2128
catggatgcc ccaatctgcc 20
<210> 2129
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2129
ctgaccccac cactgaagcc 20
<210> 2130
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2130
gcgggatcat cctctgccag 20
<210> 2131
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2131
gggccatccc cacttgactt 20
<210> 2132
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2132
gtcagccaga tatcaaggca 20
<210> 2133
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2133
gacttcttcc aactttccaa 20
<210> 2134
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2134
gctgagcccc cacattgcac 20
<210> 2135
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2135
ccagagacat taatgaagcc 20
<210> 2136
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2136
ccagacgcac catcacccaa 20
<210> 2137
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2137
cccgggccct ttgctgcttc 20
<210> 2138
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2138
tctgacagtc atatttaacc 20
<210> 2139
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2139
ccctactcat ctcagcgcga 20
<210> 2140
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2140
acatctttcc ctcactcgcc 20
<210> 2141
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2141
agcagccgcc acttctcgaa 20
<210> 2142
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2142
gagtgtggaa aatctagttt 20
<210> 2143
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2143
ctcggcataa cacatggccc 20
<210> 2144
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2144
agtttccccc tccatacaac 20
<210> 2145
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2145
ccgccgtctt tctctctgaa 20
<210> 2146
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2146
taagcaccag cctaacccct 20
<210> 2147
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2147
attgttgccc acccattcca 20
<210> 2148
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2148
ggtccgagca ccacagtgcc 20
<210> 2149
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2149
ctcgctcaca ttccctggga 20
<210> 2150
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2150
cagggtagcc ctgccaagca 20
<210> 2151
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2151
agatgcttcc ccctgcccgc 20
<210> 2152
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2152
accaggcacc ccagttgccc 20
<210> 2153
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2153
ggatacttcc aggagaccca 20
<210> 2154
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2154
ccccggctta caatcatgtt 20
<210> 2155
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2155
ctaaccccca catcagagct 20
<210> 2156
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2156
cagagggacc tctctctttt 20
<210> 2157
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2157
tccaggtaat aatatactct 20
<210> 2158
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2158
ctggtttcct cctgagcaca 20
<210> 2159
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2159
ccctgatgat ctaccccaga 20
<210> 2160
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2160
agacgcagcc cactcggata 20
<210> 2161
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2161
ctgccgctcc atccagaggt 20
<210> 2162
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2162
ccagacccgg caaaacactc 20
<210> 2163
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2163
gagccaggtc cccttccctc 20
<210> 2164
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2164
ccaaactcac accagaagcc 20
<210> 2165
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2165
atggtccacc taaatggtcc 20
<210> 2166
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2166
tcctgcaaat caccagagtc 20
<210> 2167
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2167
cctcatttcc cccgcagcat 20
<210> 2168
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2168
gctcccgtaa caaatgaccg 20
<210> 2169
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2169
gcccccccat agcttggcca 20
<210> 2170
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2170
gggtccctgt ttactgatcc 20
<210> 2171
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2171
tcagacaccc atgccgggcc 20
<210> 2172
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2172
ggctgcccgt attcttcctg 20
<210> 2173
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2173
ccgagagcgc atcccagctc 20
<210> 2174
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2174
gcagattcac ctctgtattc 20
<210> 2175
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2175
tccagcggtc cacctcctaa 20
<210> 2176
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2176
gtgtccattc tcatccactc 20
<210> 2177
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2177
cccctccata caacagggac 20
<210> 2178
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2178
gagggacctc tctcttttaa 20
<210> 2179
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2179
ctgacagtca tatttaacca 20
<210> 2180
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2180
gcttaggaac ccaccctccc 20
<210> 2181
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2181
tcagccagat atcaaggcaa 20
<210> 2182
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2182
agcaccagcc taacccctgt 20
<210> 2183
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2183
ctcctgagca cagatcgccg 20
<210> 2184
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2184
ggagagactc ctctcacaca 20
<210> 2185
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2185
acggcggcac acactatagc 20
<210> 2186
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2186
tgaccccacc actgaagcca 20
<210> 2187
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2187
ccagcatata ttcaatcaac 20
<210> 2188
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2188
agatcctcaa ctaatcacat 20
<210> 2189
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2189
atgtttcttc cctctgacct 20
<210> 2190
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2190
tgtccattct catccactca 20
<210> 2191
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2191
tcggcataac acatggcccc 20
<210> 2192
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2192
tgttccccca ccctgaatcc 20
<210> 2193
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2193
accctccgac ctttactcca 20
<210> 2194
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2194
acgctagtgc caccgtgtcc 20
<210> 2195
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2195
cccccttttt acaaatcttc 20
<210> 2196
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2196
cttacccaca tacttgtcca 20
<210> 2197
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2197
atactcttgt taccttgtca 20
<210> 2198
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2198
tcgctcacat tccctgggaa 20
<210> 2199
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2199
gacttgtgcc cataaggagc 20
<210> 2200
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2200
gacaatgatt caaacatggc 20
<210> 2201
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2201
ggtcagtaaa tgctgggttt 20
<210> 2202
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2202
aggcgagctt tacactttta 20
<210> 2203
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2203
cggatggaca ccacttcctg 20
<210> 2204
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2204
tgtgccctcc accagcaggc 20
<210> 2205
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2205
cctgcaaatc accagagtcc 20
<210> 2206
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2206
cctagagaca tccccaccgc 20
<210> 2207
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2207
cagacgcacc atcacccaac 20
<210> 2208
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2208
cttcctggca cctctcatgt 20
<210> 2209
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2209
agcatcagaa tcaataacga 20
<210> 2210
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2210
cgagagcgca tcccagctcc 20
<210> 2211
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2211
agcaagttcc cacccaccct 20
<210> 2212
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2212
ctaagaaaac tcccttgcca 20
<210> 2213
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2213
ttccctctca tcctatagac 20
<210> 2214
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2214
gggcctttcc cacatggaaa 20
<210> 2215
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2215
ttgttgccca cccattccag 20
<210> 2216
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2216
taacccccac atcagagctc 20
<210> 2217
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2217
gaattgtgct tcacaagtca 20
<210> 2218
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2218
cctttgctgc ttctaacttc 20
<210> 2219
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2219
cagattcacc tctgtattcc 20
<210> 2220
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2220
tgctgtgtcc caccctgagc 20
<210> 2221
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2221
agcaggacca ctccctccac 20
<210> 2222
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2222
cgggatcatc ctctgccagc 20
<210> 2223
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2223
gaggccacca tcccagcagt 20
<210> 2224
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2224
agcacaggca tctactgacc 20
<210> 2225
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2225
gatgcattcc atccagatat 20
<210> 2226
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2226
gggatgtgaa accagaagcc 20
<210> 2227
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2227
actggagacc caccatctcc 20
<210> 2228
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2228
caggtcagca tcacagacct 20
<210> 2229
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2229
ctgagccccc acattgcacc 20
<210> 2230
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2230
ccaggagacc cagccggcgc 20
<210> 2231
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2231
agacccggca aaacactcct 20
<210> 2232
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2232
gtccgagcac cacagtgccc 20
<210> 2233
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2233
aagggcagca cctcggagtc 20
<210> 2234
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2234
tggatgcccc aatctgccca 20
<210> 2235
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2235
gatgatctac cccagaggac 20
<210> 2236
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2236
cccgcagtca cctcccactg 20
<210> 2237
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2237
ctaaatggtc catcccagaa 20
<210> 2238
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2238
gtccctgtcc taatgagctg 20
<210> 2239
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2239
ccagcggtcc acctcctaat 20
<210> 2240
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2240
ctcctcgaac cttcacggcc 20
<210> 2241
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2241
cccgtaacaa atgaccgcaa 20
<210> 2242
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2242
catctttccc tcactcgcct 20
<210> 2243
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2243
ttcaagcctc gatcaagtaa 20
<210> 2244
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2244
ctgtggccgc ccacttctcc 20
<210> 2245
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2245
attgcacccc cagattccct 20
<210> 2246
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2246
gacgcagccc actcggataa 20
<210> 2247
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2247
cccggcttac aatcatgttt 20
<210> 2248
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2248
ggttcagctc cttgcgggat 20
<210> 2249
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2249
gcttgctgac ccaaacttca 20
<210> 2250
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2250
aggccctcca cttaatcata 20
<210> 2251
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2251
ggcagcagct ccattacctc 20
<210> 2252
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2252
gccacagtct ccacagcaga 20
<210> 2253
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2253
ccttcacggc ccctaaacca 20
<210> 2254
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2254
cgagggtctt ccatgagcgc 20
<210> 2255
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2255
ctcactcgcc tttttagagc 20
<210> 2256
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2256
ctagagacat ccccaccgca 20
<210> 2257
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2257
gttcagctcc ttgcgggatc 20
<210> 2258
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2258
tgaatccccc cacccttggc 20
<210> 2259
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2259
gctgcggacc acccacctct 20
<210> 2260
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2260
gaccgtgttt ctacataagc 20
<210> 2261
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2261
ccagtgcccc atcggtgcca 20
<210> 2262
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2262
ttcttagcat ttactgagac 20
<210> 2263
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2263
ccgcccactt ctccgagcac 20
<210> 2264
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2264
gctagtgcca ccgtgtcctc 20
<210> 2265
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2265
ggatgtgaaa ccagaagccc 20
<210> 2266
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2266
tgagccccca cattgcacct 20
<210> 2267
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2267
cccacatact tgtccagcca 20
<210> 2268
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2268
ggatgcccca atctgcccac 20
<210> 2269
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2269
atgaacaggt tccgcagcgg 20
<210> 2270
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2270
gccctccact taatcatatc 20
<210> 2271
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2271
ctgttgtgtt ggctgagggc 20
<210> 2272
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2272
cagcatatat tcaatcaact 20
<210> 2273
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2273
ctggagaccc accatctccc 20
<210> 2274
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2274
cgagctttac acttttagaa 20
<210> 2275
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2275
gttgaagccc ccaccgctga 20
<210> 2276
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2276
gaaaactccc ttgccaggca 20
<210> 2277
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2277
gccacgctgt ctaatcagct 20
<210> 2278
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2278
gtggctccaa cctgttctca 20
<210> 2279
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2279
aacccccaca tcagagctct 20
<210> 2280
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2280
taaatggtcc atcccagaag 20
<210> 2281
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2281
acacatggcc ccatacaggc 20
<210> 2282
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2282
gcaggaccac tccctccacc 20
<210> 2283
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2283
ctgcaaatca ccagagtccc 20
<210> 2284
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2284
ctttgctgct tctaacttcc 20
<210> 2285
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2285
ccccttttta caaatcttca 20
<210> 2286
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2286
cagcggtcca cctcctaata 20
<210> 2287
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2287
tccctctcat cctatagaca 20
<210> 2288
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2288
gctgacccaa acttcaagcc 20
<210> 2289
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2289
gcattccatc cagatatggc 20
<210> 2290
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2290
ctggattcct gttccaggac 20
<210> 2291
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2291
cggcaaaaca ctcctggatt 20
<210> 2292
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2292
atggacacca cttcctgccc 20
<210> 2293
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2293
gctgtgtccc accctgagct 20
<210> 2294
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2294
gggacctctc tcttttaatc 20
<210> 2295
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2295
ttcctggcac ctctcatgtc 20
<210> 2296
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2296
gagagactcc tctcacacac 20
<210> 2297
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2297
aggagcagtc tcagctgcca 20
<210> 2298
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2298
ggcaacacag gcaaaccgac 20
<210> 2299
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2299
cagcagacac tcaacttgac 20
<210> 2300
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2300
cgctcacatt ccctgggaac 20
<210> 2301
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2301
gggtttagaa aatgaggctt 20
<210> 2302
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2302
ctgcccgtat tcttcctgaa 20
<210> 2303
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2303
gcagcagctc cattacctct 20
<210> 2304
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2304
aaggcaacag caacagtgcc 20
<210> 2305
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2305
taagctctgt ccagcaggcc 20
<210> 2306
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2306
gttgcccacc cattccagca 20
<210> 2307
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2307
atcactctgc ttcaagggct 20
<210> 2308
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2308
gcacaggcat ctactgaccc 20
<210> 2309
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2309
tctgtattcc acacacattt 20
<210> 2310
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2310
ccctccgacc tttactccag 20
<210> 2311
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2311
ctggccactc ctcctaggcg 20
<210> 2312
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2312
cccgcaggca tcctgggcct 20
<210> 2313
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2313
caccagccta acccctgttc 20
<210> 2314
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2314
ctgtcccgcc ctccatggca 20
<210> 2315
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2315
agacgcacca tcacccaaca 20
<210> 2316
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2316
gtcactctgt caatttgtct 20
<210> 2317
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2317
cgtgaagtcc ctcccgggac 20
<210> 2318
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2318
tgctgtggtt acaaatgacc 20
<210> 2319
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2319
gcaagttccc acccaccctc 20
<210> 2320
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2320
ccgcagtcac ctcccactgc 20
<210> 2321
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2321
atgatctacc ccagaggacc 20
<210> 2322
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2322
gaccgcaaac ttagcagcta 20
<210> 2323
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2323
gagggcagct cccttcgcct 20
<210> 2324
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2324
aggtcagcat cacagacctc 20
<210> 2325
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2325
cggcggcaca cactatagcc 20
<210> 2326
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2326
tcagaatcaa taacgatctg 20
<210> 2327
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2327
cttccaggca ctcgcaggcc 20
<210> 2328
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2328
gtccattctc atccactcat 20
<210> 2329
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2329
ggataatcgc cctttgatta 20
<210> 2330
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2330
ccgtgtttct acataagcca 20
<210> 2331
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2331
acttagcagc taaaacgaca 20
<210> 2332
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2332
ggacaccact tcctgcccaa 20
<210> 2333
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2333
tagagacatc cccaccgcaa 20
<210> 2334
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2334
acccccacat cagagctcta 20
<210> 2335
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2335
caggtgcctc taacatagac 20
<210> 2336
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2336
ggcctgggac ccatctggac 20
<210> 2337
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2337
agcatatatt caatcaactt 20
<210> 2338
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2338
gtcagcatca cagacctcct 20
<210> 2339
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2339
aaatggtcca tcccagaagg 20
<210> 2340
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2340
cctcagtgct tactgagcac 20
<210> 2341
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2341
ttcctgttcc aggactccaa 20
<210> 2342
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2342
gaggctttgc tttaaaaggt 20
<210> 2343
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2343
ccacgctgtc taatcagctc 20
<210> 2344
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2344
ggacctctct cttttaatcc 20
<210> 2345
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2345
actcgccttt ttagagccct 20
<210> 2346
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2346
gtggagtgtc cctctgcacc 20
<210> 2347
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2347
cagatccaaa acagaggcca 20
<210> 2348
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2348
ggcattgtgg caaacaggtc 20
<210> 2349
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2349
cctgcagacc caacttccac 20
<210> 2350
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2350
cccacccacc ctcatcgcgg 20
<210> 2351
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2351
tcactctgct tcaagggctt 20
<210> 2352
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2352
agagactcct ctcacacacc 20
<210> 2353
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2353
tgacccaaac ttcaagccac 20
<210> 2354
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2354
cttcacggcc cctaaaccac 20
<210> 2355
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2355
ttaaaaggaa ctctaccttc 20
<210> 2356
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2356
agcagacact caacttgacc 20
<210> 2357
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2357
cacatggccc catacaggca 20
<210> 2358
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2358
gcaaatcacc agagtcccca 20
<210> 2359
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2359
atctactgac ccctctggaa 20
<210> 2360
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2360
agcggtccac ctcctaatac 20
<210> 2361
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2361
cgcagtcacc tcccactgcc 20
<210> 2362
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2362
tgcacagatc ttcatagcaa 20
<210> 2363
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2363
ggtctgctca cctcacttgc 20
<210> 2364
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2364
ggaccaaccc cagatggtcc 20
<210> 2365
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2365
agcagctcca ttacctctgc 20
<210> 2366
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2366
ttttacaaat cttcatggtc 20
<210> 2367
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2367
gggagatgtc tctccaagct 20
<210> 2368
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2368
ggcctcagca ccagatgcct 20
<210> 2369
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2369
tggccactcc tcctaggcgg 20
<210> 2370
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2370
gggtccgtca cacccagcag 20
<210> 2371
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2371
cctctcatcc tatagacacc 20
<210> 2372
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2372
tcctggcacc tctcatgtcc 20
<210> 2373
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2373
gctttacact tttagaagaa 20
<210> 2374
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2374
gccaccgtgt cctcacacgc 20
<210> 2375
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2375
tgggaacgaa cccacagccc 20
<210> 2376
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2376
cctgggttcc acacctgacc 20
<210> 2377
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2377
gcgctgctcc acctgcccaa 20
<210> 2378
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2378
gcccacttct ccgagcacca 20
<210> 2379
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2379
atgacatgca tttcactcac 20
<210> 2380
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2380
gctactgcaa tgaccggcca 20
<210> 2381
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2381
taattcaaat tcaactgctc 20
<210> 2382
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2382
ggaaaggtct tcacaggcca 20
<210> 2383
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2383
ccattctcat ccactcatca 20
<210> 2384
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2384
accagcctaa cccctgttcc 20
<210> 2385
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2385
gcccgtattc ttcctgaaga 20
<210> 2386
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2386
ccctccactt aatcatatct 20
<210> 2387
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2387
gccatgccag actcacccaa 20
<210> 2388
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2388
gcccagttct ccttctcaaa 20
<210> 2389
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2389
tcatgctcag aaaatgacca 20
<210> 2390
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2390
cattccatcc agatatggct 20
<210> 2391
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2391
cgcaccatca cccaacagca 20
<210> 2392
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2392
atcctgggcc tctccagact 20
<210> 2393
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2393
tggttgggtc tccctgcccc 20
<210> 2394
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2394
gctgttgtcc ccagcaggcc 20
<210> 2395
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2395
tgctgcttct aacttccaga 20
<210> 2396
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2396
gggagcccat ttcccaagtt 20
<210> 2397
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2397
ttgccaggca cccataggtc 20
<210> 2398
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2398
agagcagcaa catggagccc 20
<210> 2399
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2399
tggagaccca ccatctcccc 20
<210> 2400
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2400
gaccacaaat tcaattgcta 20
<210> 2401
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2401
gaatcccccc acccttggct 20
<210> 2402
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2402
cctccgacct ttactccagg 20
<210> 2403
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2403
ggcggcacac actatagcct 20
<210> 2404
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2404
gagatgctct caccaggagc 20
<210> 2405
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2405
gcacttccac cttacccaga 20
<210> 2406
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2406
ccaacttcca ctttgcaaaa 20
<210> 2407
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2407
aaaatgacca actcactggc 20
<210> 2408
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2408
acaagagaac atctgtgccg 20
<210> 2409
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2409
agcccagtca cccgtgagca 20
<210> 2410
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2410
catcactgtc ccaatcaccc 20
<210> 2411
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2411
acacgcccag gcaaaccgcc 20
<210> 2412
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2412
cactaggcct ccatgcaccc 20
<210> 2413
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2413
cgacctttac tccaggcctc 20
<210> 2414
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2414
cagacgcatc catttcctcc 20
<210> 2415
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2415
tgggacccag tcatgaacta 20
<210> 2416
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2416
gggttctgcc ctcttctgac 20
<210> 2417
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2417
cccacacgca acaaaggcac 20
<210> 2418
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2418
ccataggtca aaaagggccc 20
<210> 2419
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2419
agcgaggcca cccatgtgaa 20
<210> 2420
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2420
atcttcatag caacccatgc 20
<210> 2421
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2421
cacaagtgtt ttaagcacac 20
<210> 2422
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2422
tgcactgaac cacctggtgc 20
<210> 2423
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2423
ggtccacccc agacgatcca 20
<210> 2424
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2424
caggaggccc ttcaagctcc 20
<210> 2425
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2425
tgtggtcccc ctcgccacgc 20
<210> 2426
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2426
gcagctgact ctcccgcccc 20
<210> 2427
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2427
ctggagtact ctccacagac 20
<210> 2428
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2428
ccacttgctc cactgtgcga 20
<210> 2429
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2429
gaggcataaa cacacttaca 20
<210> 2430
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2430
tcctgtgtcc acacctgcgg 20
<210> 2431
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2431
ctcacgggac tccatcatta 20
<210> 2432
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2432
agactcaccc aaccctacca 20
<210> 2433
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2433
gccggacacc aggcctgcaa 20
<210> 2434
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2434
tttggacacc atcccgggcc 20
<210> 2435
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2435
ccaccgcaac cccttctgct 20
<210> 2436
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2436
tctccaccca cagaatagga 20
<210> 2437
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2437
gccctgcccc agacgcaccg 20
<210> 2438
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2438
acatcgccat tcccagagtc 20
<210> 2439
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2439
ccacagatta taacccacag 20
<210> 2440
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2440
ccccagcaca tcctggcctt 20
<210> 2441
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2441
gaccagaccc cagaatctcc 20
<210> 2442
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2442
tgaaaacgat ccattttccc 20
<210> 2443
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2443
ccatggtgct tcctagggca 20
<210> 2444
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2444
aggcggtaca tccacgggct 20
<210> 2445
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2445
atggatacag tccctaggac 20
<210> 2446
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2446
tctgaagatt cctccccgca 20
<210> 2447
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2447
ccatcgcccc acactccact 20
<210> 2448
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2448
gtggctctcc cttgcagaat 20
<210> 2449
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2449
cgtgtcctca cacgctcctc 20
<210> 2450
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2450
cgggaaagcc acacacaact 20
<210> 2451
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2451
gctgtgagcc tcacctcccc 20
<210> 2452
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2452
ggtacatccc acatctgcgg 20
<210> 2453
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2453
cctgatgccc tcccccgagc 20
<210> 2454
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2454
tcccccgaca tacacagcat 20
<210> 2455
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2455
gcacacaacc catgtgccca 20
<210> 2456
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2456
catctcccga tatagcccta 20
<210> 2457
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2457
ctgtccggag aatccaggcc 20
<210> 2458
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2458
cctaaaccac cactgcccct 20
<210> 2459
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2459
cggagagtcc tcccagccct 20
<210> 2460
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2460
ctgccttgcc acacaaaaca 20
<210> 2461
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2461
tcgacacaca acatacacaa 20
<210> 2462
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2462
cccagacccc tcaccaaaca 20
<210> 2463
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2463
accagacacc agcccaagca 20
<210> 2464
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2464
gctgccgttt tcaagaatta 20
<210> 2465
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2465
ccagagtgca gaacagcagc 20
<210> 2466
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2466
gaatcctcac ccttagccct 20
<210> 2467
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2467
ccaagagacc ccacctggcc 20
<210> 2468
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2468
aaccagtgag tcactacgaa 20
<210> 2469
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2469
aacaagggct ctcacacctc 20
<210> 2470
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2470
gcctcctgaa atctgggctt 20
<210> 2471
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2471
tgtcacccca ccagcagcat 20
<210> 2472
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2472
caggtgcctt cctttgccgt 20
<210> 2473
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2473
tccgtggacc ttctgggtcc 20
<210> 2474
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2474
tcagcgaact taattatatc 20
<210> 2475
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2475
gttgacccca ccccagaggc 20
<210> 2476
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2476
ctctcatcct atagacacca 20
<210> 2477
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2477
aggtaagtgt aaaatggtcc 20
<210> 2478
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2478
gtgttgatca tctccaggac 20
<210> 2479
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2479
ctaatcagct cccaatccct 20
<210> 2480
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2480
ggagctgcca gcaatagcaa 20
<210> 2481
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2481
cagatggtcc accctggaca 20
<210> 2482
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2482
ccttgcaaat atcccaggtt 20
<210> 2483
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2483
gtagagtccc agcacctgcc 20
<210> 2484
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2484
agtcttgaaa ccatggtcct 20
<210> 2485
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2485
caccagcgca cacctgccac 20
<210> 2486
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2486
tgcacagctc ccatggatga 20
<210> 2487
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2487
ggcccaagca cttcacaccc 20
<210> 2488
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2488
gggcctggtt tccctattta 20
<210> 2489
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2489
gtccacggca ccctctcctc 20
<210> 2490
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2490
ggcctcagcc ttcactcaca 20
<210> 2491
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2491
ccactcctga ctcttggttc 20
<210> 2492
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2492
ccctgatgaa acttcagccc 20
<210> 2493
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2493
gtgcctcccc ccacggcagc 20
<210> 2494
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2494
caaggcagca ctcactctac 20
<210> 2495
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2495
ccattttaac cctctttgcc 20
<210> 2496
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2496
atctgaagcc ccaaactagc 20
<210> 2497
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2497
aggtgccgaa ccttaaggac 20
<210> 2498
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2498
acactatgcc actaaggaca 20
<210> 2499
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2499
ggctcgctgt caacacacga 20
<210> 2500
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2500
ccaagggacc cactgaggct 20
<210> 2501
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2501
tcttggctca cccagatcat 20
<210> 2502
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2502
ccctggatgc tcaacagccg 20
<210> 2503
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2503
cggaacacac tttcactctc 20
<210> 2504
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2504
tcacagcccc agccttcgcc 20
<210> 2505
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2505
cccttactca tcagtggccg 20
<210> 2506
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2506
tcccagacac actcagggcc 20
<210> 2507
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2507
cacgcagaaa ctctgggctc 20
<210> 2508
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2508
caggaataca gcattacaat 20
<210> 2509
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2509
caggtaagca tttaaacctt 20
<210> 2510
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2510
actggagaca ccatcttcgg 20
<210> 2511
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2511
gagagactcc acctgtccaa 20
<210> 2512
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2512
aagttgccca ctcctgtact 20
<210> 2513
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2513
gaattattcc catgggctca 20
<210> 2514
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2514
ctgcggaatc ccctcctgca 20
<210> 2515
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2515
cactggcttc cggacagcca 20
<210> 2516
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2516
tccagaagaa caaacctacc 20
<210> 2517
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2517
tgggcccgca catctcacat 20
<210> 2518
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2518
ggatgatcca ccccagacgg 20
<210> 2519
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2519
gtgctcagcc ctttgcttca 20
<210> 2520
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2520
ctgctcaaac catcaggacc 20
<210> 2521
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2521
tcttggtttc caatcatcat 20
<210> 2522
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2522
ctgcacatcc cgatttggcc 20
<210> 2523
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2523
ctgtccactt cctccaccgg 20
<210> 2524
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2524
accacgctag acctcaggct 20
<210> 2525
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2525
acagtgcccc ctcagtgggc 20
<210> 2526
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2526
ggacacagtt caatcccgaa 20
<210> 2527
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2527
gtggaccttc catcgctcct 20
<210> 2528
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2528
cagaattctc cattcctgat 20
<210> 2529
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2529
tctccctcca atagaacctc 20
<210> 2530
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2530
ttatgactca atgagcccaa 20
<210> 2531
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2531
ggagactcat cccaccccac 20
<210> 2532
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2532
aggagctaat gaaacagcct 20
<210> 2533
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2533
caccaccaag aaacatcgca 20
<210> 2534
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2534
ctagacaatc caccctggat 20
<210> 2535
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2535
tcagggtcat cctcgaagcc 20
<210> 2536
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2536
gaggaaaact ccaatgctgc 20
<210> 2537
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2537
aaggagacct cactgctcac 20
<210> 2538
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2538
gtacaaacca gtaaggaacc 20
<210> 2539
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2539
ccgccatgcc tccctgacat 20
<210> 2540
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2540
ggattcgccc tctcagggtc 20
<210> 2541
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2541
tggcaggtcc accctccccc 20
<210> 2542
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2542
gccacccttc ccaaactcag 20
<210> 2543
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2543
gtgcatcacc aggcgagccc 20
<210> 2544
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2544
tgggatggct tctaatggca 20
<210> 2545
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2545
acccctctca catgcccggc 20
<210> 2546
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2546
tgtttgtgcc caccacctct 20
<210> 2547
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2547
tgagctggcc ctccccccgc 20
<210> 2548
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2548
cgggaagctc cacaccagct 20
<210> 2549
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2549
actgctgcca ttcacatgac 20
<210> 2550
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2550
ggctggccca actctagctg 20
<210> 2551
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2551
gtgagctcca cctcatgccg 20
<210> 2552
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2552
gatggaagcc cccttcaacc 20
<210> 2553
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2553
cagctcattt cactccggca 20
<210> 2554
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2554
ggcatgggac aatctccccc 20
<210> 2555
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2555
acacaggtcc ataccccacc 20
<210> 2556
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2556
aggtcgggct atctaaccca 20
<210> 2557
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2557
caggctactc cccccaggcc 20
<210> 2558
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2558
ccacgccatc tcctgagttc 20
<210> 2559
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2559
gccagactca cccaacccta 20
<210> 2560
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2560
gggttgtgga cctctaggta 20
<210> 2561
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2561
cctttgctcc cctgtgggcc 20
<210> 2562
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2562
gcggccctca ctctccggcc 20
<210> 2563
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2563
cccctcccca cctactgcgg 20
<210> 2564
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2564
gtgaaagacc ctctctggtc 20
<210> 2565
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2565
cccgttctcc caccttgact 20
<210> 2566
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2566
ctgcatctcc cgatatagcc 20
<210> 2567
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2567
accatcggca cacaacccat 20
<210> 2568
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2568
ccgtattctt cctgaagact 20
<210> 2569
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2569
gcttgggaca gcaaacagcc 20
<210> 2570
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2570
atccctgtcc acacagggtc 20
<210> 2571
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2571
tcacacccag cagacagccg 20
<210> 2572
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2572
agtcacctcc cactgcctgc 20
<210> 2573
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2573
ctgacagctt ctcctggcca 20
<210> 2574
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2574
tatattcaat caacttagga 20
<210> 2575
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2575
cccgagctaa cacccgtcct 20
<210> 2576
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2576
gaccccagca catcctggcc 20
<210> 2577
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2577
tgctccagcc tttccgtgga 20
<210> 2578
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2578
cacagatctt catagcaacc 20
<210> 2579
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2579
acctgtctcc tctctcccgt 20
<210> 2580
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2580
gagcaccacc acaaaaagga 20
<210> 2581
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2581
gcggcacttc caccttaccc 20
<210> 2582
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2582
cttcctgccc aatatcggaa 20
<210> 2583
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2583
tgcatgtcac cccaccagca 20
<210> 2584
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2584
cccccacctt taccctggct 20
<210> 2585
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2585
gtgtttctac ataagccaca 20
<210> 2586
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2586
gtttatctgg caaacagcaa 20
<210> 2587
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2587
tttctgacct cactaggcct 20
<210> 2588
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2588
aggctcagtc tttccagtca 20
<210> 2589
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2589
actggagccc tcccagaccc 20
<210> 2590
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2590
cccctaaacc accactgccc 20
<210> 2591
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2591
gacccaactt ccactttgca 20
<210> 2592
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2592
cttccctctc atcctataga 20
<210> 2593
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2593
gtgcctctaa catagacact 20
<210> 2594
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2594
gcatttcact cactcaggac 20
<210> 2595
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2595
acaggttccg cagcggcggc 20
<210> 2596
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2596
gagcccattt cccaagttca 20
<210> 2597
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2597
ctcaaactct cctagtgggt 20
<210> 2598
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2598
cagcaggcca ccaccccgtc 20
<210> 2599
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2599
aaagcatgca tcccccgaca 20
<210> 2600
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2600
gaccatcgcc ccacactcca 20
<210> 2601
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2601
gagacatccc caccgcaacc 20
<210> 2602
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2602
ttggagttcc cacagtgtga 20
<210> 2603
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2603
acgctgtcta atcagctccc 20
<210> 2604
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2604
caccgtgtcc tcacacgctc 20
<210> 2605
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2605
cagctccatt acctctgctc 20
<210> 2606
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2606
atggtccacc ttgaatggtc 20
<210> 2607
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2607
ctgctaatcc ccctcaccac 20
<210> 2608
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2608
cccaaccatc cccagaggac 20
<210> 2609
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2609
gctcagcgaa cttaattata 20
<210> 2610
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2610
tcacaggcca cctgttcccc 20
<210> 2611
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2611
gggagcctca ccatgccctt 20
<210> 2612
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2612
caccatcacc caacagcatg 20
<210> 2613
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2613
cttcatggtc ctcatggata 20
<210> 2614
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2614
cggctgctcc atgatgcagt 20
<210> 2615
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2615
cagaaaatga ccaactcact 20
<210> 2616
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2616
gattggtgaa tcaaagccaa 20
<210> 2617
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2617
tggctgagcc ctcccgtccc 20
<210> 2618
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2618
tgcagacgca tccatttcct 20
<210> 2619
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2619
gatatggctc ctactccacc 20
<210> 2620
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2620
gccacgcccc tcgccgacca 20
<210> 2621
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2621
gaaatggaca cacccggaca 20
<210> 2622
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2622
gaggctccac tgccttgcca 20
<210> 2623
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2623
ggctttgctt taaaaggtaa 20
<210> 2624
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2624
tgtcactgtc caccagggca 20
<210> 2625
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2625
aatggtccac cccagacgat 20
<210> 2626
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2626
gcaccccaca accccaagtc 20
<210> 2627
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2627
agacccacca tctccccaga 20
<210> 2628
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2628
caattgctaa accacacttt 20
<210> 2629
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2629
ggccacagat tataacccac 20
<210> 2630
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2630
gtagggcact cacctggatc 20
<210> 2631
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2631
agtgccggaa tcctcaccct 20
<210> 2632
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2632
ggtgcttttc catagcagct 20
<210> 2633
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2633
gccaggcacc cataggtcaa 20
<210> 2634
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2634
cagaaagcca attccagctc 20
<210> 2635
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2635
ctggcatcca ccggctcccc 20
<210> 2636
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2636
ctggtgcctt ctacaggctc 20
<210> 2637
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2637
cagggcagaa ttaccttgca 20
<210> 2638
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2638
cgtcctccca cctcacacgg 20
<210> 2639
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2639
ctgccagccc cctcagcgga 20
<210> 2640
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2640
ctgagcactc ttacgcataa 20
<210> 2641
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2641
gtcccatctc cacacagggc 20
<210> 2642
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2642
ggacctcaac cccctacttg 20
<210> 2643
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2643
ggtctttctc ctcccaccac 20
<210> 2644
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2644
caccccccaa ttcctacctc 20
<210> 2645
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2645
gtcttagcca ccaaggcctt 20
<210> 2646
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2646
cagctgtacc cacaggcggc 20
<210> 2647
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2647
cagaggctcc ctaggagcac 20
<210> 2648
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2648
ctataatgct ctcatggctc 20
<210> 2649
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2649
gatccacact ccagaagaac 20
<210> 2650
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2650
tccaaactca caggctactc 20
<210> 2651
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2651
acaggccatt cccactcgct 20
<210> 2652
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2652
cttaattacc tctaaagaac 20
<210> 2653
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2653
acgacaggca acagcagcct 20
<210> 2654
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2654
accgtggcca cctgcatgac 20
<210> 2655
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2655
gcaggtagtc atacacagat 20
<210> 2656
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2656
tgggctcatt attagagcac 20
<210> 2657
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2657
gacagattca aaaacaggcc 20
<210> 2658
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2658
gcaggcctcc ccattgtcca 20
<210> 2659
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2659
agctctatct tcccagacac 20
<210> 2660
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2660
ctggacattc tcaaagtgcc 20
<210> 2661
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2661
ccagaggacc cacctgcagt 20
<210> 2662
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2662
tccaggatcc ctatgggctc 20
<210> 2663
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2663
cagtgcctca cacgcggtca 20
<210> 2664
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2664
gcccaaaact acagcggtct 20
<210> 2665
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2665
tggccttgtc ttacttctta 20
<210> 2666
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2666
gcccatccac ccacttggac 20
<210> 2667
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2667
caggtgcttg accttagcct 20
<210> 2668
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2668
tgctcaactc cagagaacca 20
<210> 2669
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2669
cagcatccaa acccacggtg 20
<210> 2670
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2670
gaagctctaa tccctggcca 20
<210> 2671
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2671
tcagtgacac tcaaaagtgc 20
<210> 2672
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2672
gcgactctga acctctgcct 20
<210> 2673
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2673
cagctggaac tcctgacacc 20
<210> 2674
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2674
tgcaaccctg cccattgcca 20
<210> 2675
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2675
agggaacccc accacatcac 20
<210> 2676
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2676
cgcacccctc tcacatgccc 20
<210> 2677
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2677
gctgggcccg catctggagc 20
<210> 2678
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2678
ccaagattac cctcaggatc 20
<210> 2679
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2679
cccttaacca cctgtgcatc 20
<210> 2680
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2680
tgacgggacc atactcagga 20
<210> 2681
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2681
gcgcagccca gccctagctt 20
<210> 2682
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2682
ggtccacccc agacagtcca 20
<210> 2683
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2683
acgggtcccc atcttgccta 20
<210> 2684
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2684
cgcctgaatc ccccacgcca 20
<210> 2685
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2685
ccaaagctca caacactcag 20
<210> 2686
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2686
tctgttttac actaatgcgg 20
<210> 2687
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2687
tggatggtcc cccctggaca 20
<210> 2688
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2688
ccaaagtctc ccccctaccc 20
<210> 2689
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2689
gctggcccca catgcaggca 20
<210> 2690
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2690
aaaactctcc tcactagcct 20
<210> 2691
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2691
cccacacgcc atacagttat 20
<210> 2692
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2692
caagtcctca cctgcaatcc 20
<210> 2693
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2693
ccaacaggtt ctacctacca 20
<210> 2694
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2694
aagcccccaa ctcacttgcc 20
<210> 2695
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2695
cacccgtcac cctctgcacc 20
<210> 2696
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2696
ccctgctcag cacgaagcca 20
<210> 2697
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2697
tgagctccca actctgtcca 20
<210> 2698
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2698
gcataacaca aatattgcca 20
<210> 2699
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2699
gtccttggca ttcactgagc 20
<210> 2700
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2700
aggctgggca ttatccctca 20
<210> 2701
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2701
gactgggatc ccacctggcc 20
<210> 2702
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2702
tcccaggctt ctcttgggac 20
<210> 2703
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2703
ccgggttcgc ccttactcat 20
<210> 2704
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2704
ctgcaattca acactgcctt 20
<210> 2705
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2705
cccagaccat catcgatgcc 20
<210> 2706
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2706
ctgctgtcca ctcctgaaca 20
<210> 2707
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2707
aagctgctaa aagaaatgcc 20
<210> 2708
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2708
gcatgtcgcc ctggctgcct 20
<210> 2709
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2709
gatctgattg gaaataggtc 20
<210> 2710
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2710
caccagctca tttcactccg 20
<210> 2711
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2711
gtggagactc atcccacccc 20
<210> 2712
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2712
atgaattatt cccatgggct 20
<210> 2713
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2713
gcctcttctg caaatgggac 20
<210> 2714
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2714
gaactggacc acgctagacc 20
<210> 2715
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2715
atataaccac cccctacccc 20
<210> 2716
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2716
gccattccca ctcgctgtgc 20
<210> 2717
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2717
agctcacaac actcagggta 20
<210> 2718
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2718
tcatagggcc tgcctagcct 20
<210> 2719
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2719
gccattttaa ccctctttgc 20
<210> 2720
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2720
gaagctgcaa ttcagagcat 20
<210> 2721
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2721
ttgccaggac ctcactggct 20
<210> 2722
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2722
ccagctcatt tcactccggc 20
<210> 2723
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2723
cgctcactcc ctgattctga 20
<210> 2724
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2724
ctggatgatc caccccagac 20
<210> 2725
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2725
cacccctctc acatgcccgg 20
<210> 2726
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2726
tagtgcctcc ccccacggca 20
<210> 2727
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2727
ggtgagctgg ccctcccccc 20
<210> 2728
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2728
gcctgctgca catcccgatt 20
<210> 2729
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2729
tttgggataa taataggtcc 20
<210> 2730
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2730
cccacgggac cctcactgcc 20
<210> 2731
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2731
ctgccagccc taacttagct 20
<210> 2732
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2732
cccctactct ctgctggtca 20
<210> 2733
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2733
tggctcccac cccatggact 20
<210> 2734
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2734
ctggctggcc caactctagc 20
<210> 2735
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2735
ccctaggtcc tgcccaggcc 20
<210> 2736
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2736
gagtcttgaa accatggtcc 20
<210> 2737
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2737
ctatcttccc agacacactc 20
<210> 2738
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2738
ggccggaaca cactttcact 20
<210> 2739
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2739
ctggttccac catcaagagc 20
<210> 2740
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2740
gagtcccacc accaagaaac 20
<210> 2741
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2741
catgaatgtc cctaagagca 20
<210> 2742
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2742
agttatgact caatgagccc 20
<210> 2743
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2743
ccactctccc tccaatagaa 20
<210> 2744
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2744
ccacagggct ctgcccgccc 20
<210> 2745
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2745
gaggcttaag tctcaggtca 20
<210> 2746
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2746
ttggcaggtc caccctcccc 20
<210> 2747
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2747
ttgtgtcaca cacatgagtc 20
<210> 2748
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2748
gtcttggttt ccaatcatca 20
<210> 2749
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2749
ttcagggtca tcctcgaagc 20
<210> 2750
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2750
tcggtggacc ttccatcgct 20
<210> 2751
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2751
cacagatccc acctgtgtgt 20
<210> 2752
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2752
ggcggatccc agcctctgca 20
<210> 2753
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2753
acccgtctgc tcaaaccatc 20
<210> 2754
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2754
tgctcactga ccctgagtca 20
<210> 2755
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2755
catctcccca atagcagggt 20
<210> 2756
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2756
ccagggttta atgatcccct 20
<210> 2757
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2757
gaggagctaa tgaaacagcc 20
<210> 2758
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2758
cactcctgaa cactcaggaa 20
<210> 2759
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2759
gatcttggct cacccagatc 20
<210> 2760
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2760
accttgcaaa tatcccaggt 20
<210> 2761
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2761
caaggagacc tcactgctca 20
<210> 2762
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2762
aggttctacc taccaaggga 20
<210> 2763
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2763
cgtacaaacc agtaaggaac 20
<210> 2764
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2764
tctgtccact tcctccaccg 20
<210> 2765
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2765
tcattcccgc catctgcgga 20
<210> 2766
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2766
gacacaggtc cataccccac 20
<210> 2767
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2767
agagagactc cacctgtcca 20
<210> 2768
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2768
ccgggaagct ccacaccagc 20
<210> 2769
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2769
agggtcagac cctctgagcc 20
<210> 2770
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2770
gaggtttcta cagccaccgt 20
<210> 2771
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2771
ctacgggtat gaaaaagtca 20
<210> 2772
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2772
gctttgatat ataaatcttg 20
<210> 2773
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2773
gtcacgggac agctcaccca 20
<210> 2774
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2774
caacactgcc ttactgtgaa 20
<210> 2775
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2775
gcagaattct ccattcctga 20
<210> 2776
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2776
aggcagacga cccctggtct 20
<210> 2777
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2777
aaagttgccc actcctgtac 20
<210> 2778
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2778
tctgagaccc atctgggtct 20
<210> 2779
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2779
cctagacaat ccaccctgga 20
<210> 2780
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2780
cgttagagaa ttacacaaaa 20
<210> 2781
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2781
acaccagcgc acacctgcca 20
<210> 2782
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2782
acaggctact ccccccaggc 20
<210> 2783
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2783
gcccttactc atcagtggcc 20
<210> 2784
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2784
ggtgagctcc acctcatgcc 20
<210> 2785
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2785
cacgagtacc ctctgccagc 20
<210> 2786
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2786
cactccagaa gaacaaacct 20
<210> 2787
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2787
aaccccacca catcactggc 20
<210> 2788
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2788
accagagtcc ccaccggagc 20
<210> 2789
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2789
ggagtgtccc tctgcacccc 20
<210> 2790
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2790
aacaggttcc gcagcggcgg 20
<210> 2791
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2791
gcagtcacct cccactgcct 20
<210> 2792
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2792
gcagctccat tacctctgct 20
<210> 2793
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2793
cgtgtttcta cataagccac 20
<210> 2794
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2794
caagcggcac ttccacctta 20
<210> 2795
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2795
ccacccaccc tcatcgcggc 20
<210> 2796
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2796
catgtcctgc ttaatgcctg 20
<210> 2797
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2797
tgcatttcac tcactcagga 20
<210> 2798
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2798
ggagacccac catctcccca 20
<210> 2799
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2799
cttctgagtc caaactggga 20
<210> 2800
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2800
cagacactca acttgacctc 20
<210> 2801
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2801
gccctgacca tcgccccaca 20
<210> 2802
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2802
ggctcagctt ccctctcgct 20
<210> 2803
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2803
aggtgcctct aacatagaca 20
<210> 2804
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2804
ttagcagcta aaacgacacc 20
<210> 2805
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2805
gcacagatct tcatagcaac 20
<210> 2806
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2806
attccatcca gatatggctc 20
<210> 2807
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2807
gcggtccacc tcctaatacc 20
<210> 2808
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2808
ttactgagca ccactgcagt 20
<210> 2809
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2809
aacgaaccca cagcccaccg 20
<210> 2810
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2810
cacgctgtct aatcagctcc 20
<210> 2811
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2811
attcaattgc taaaccacac 20
<210> 2812
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2812
ctcatttgtt tatctggcaa 20
<210> 2813
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2813
tctactgacc cctctggaac 20
<210> 2814
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2814
ggagcccatt tcccaagttc 20
<210> 2815
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2815
ccaggtttat gatcgaggga 20
<210> 2816
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2816
aaggtcttca caggccacct 20
<210> 2817
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2817
ccttccctct catcctatag 20
<210> 2818
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2818
tctgctaatc cccctcacca 20
<210> 2819
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2819
tttacaaatc ttcatggtcc 20
<210> 2820
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2820
aggctttgct ttaaaaggta 20
<210> 2821
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2821
tgcgggatct gtagtaggcc 20
<210> 2822
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2822
agactctgcc actcctgcac 20
<210> 2823
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2823
tgcagaccca acttccactt 20
<210> 2824
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2824
tgacgaggct ccactgcctt 20
<210> 2825
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2825
gcaccatcac ccaacagcat 20
<210> 2826
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2826
cggccacaga ttataaccca 20
<210> 2827
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2827
gaatggtcca ccccagacga 20
<210> 2828
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2828
atgcatgtca ccccaccagc 20
<210> 2829
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2829
ttcaactgct cagcgaactt 20
<210> 2830
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2830
agagacatcc ccaccgcaac 20
<210> 2831
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2831
acatggcccc atacaggcac 20
<210> 2832
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2832
gcccctaaac caccactgcc 20
<210> 2833
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2833
aaacaggtcc ctcccgagct 20
<210> 2834
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2834
cacttcctgc ccaatatcgg 20
<210> 2835
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2835
gcggcacaca ctatagcctc 20
<210> 2836
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2836
gctgacagct tctcctggcc 20
<210> 2837
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2837
aggatggtca tccttcggct 20
<210> 2838
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2838
ggtggtgccc ttcatggagc 20
<210> 2839
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2839
gtctgctcac ctcacttgct 20
<210> 2840
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2840
tctccgagca ccaccacaaa 20
<210> 2841
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2841
cagagctcta acacctggga 20
<210> 2842
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2842
gctgcttcta acttccagaa 20
<210> 2843
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2843
ttgtcactgt ccaccagggc 20
<210> 2844
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2844
tccgtcacac ccagcagaca 20
<210> 2845
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2845
atgccagact cacccaaccc 20
<210> 2846
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2846
gcccaaccat ccccagagga 20
<210> 2847
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2847
gctggaggcc ctcgcagctc 20
<210> 2848
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2848
gctcagaaaa tgaccaactc 20
<210> 2849
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2849
cccgtattct tcctgaagac 20
<210> 2850
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2850
ctgttgtccc cagcaggcca 20
<210> 2851
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2851
gaactctacc ttcagcccgt 20
<210> 2852
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2852
tctgcccgtc ctctcccctt 20
<210> 2853
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2853
gatgctctca ccaggagcct 20
<210> 2854
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2854
gctgcggccc tcactctccg 20
<210> 2855
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2855
ctccgacctt tactccaggc 20
<210> 2856
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2856
gacccaaact tcaagccacc 20
<210> 2857
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2857
cagttctcct tctcaaactc 20
<210> 2858
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2858
ctgggaccca tctggacccc 20
<210> 2859
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2859
tgccaggcac ccataggtca 20
<210> 2860
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2860
ctagatggtc caccttgaat 20
<210> 2861
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2861
tcaagggctt ttactggtgc 20
<210> 2862
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2862
gcatatattc aatcaactta 20
<210> 2863
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2863
gtttctgacc tcactaggcc 20
<210> 2864
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2864
ttcatggtcc tcatggatac 20
<210> 2865
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2865
aggatctccc agggctgccg 20
<210> 2866
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2866
aaggtaagtg taaaatggtc 20
<210> 2867
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2867
agcaccagac accagcccaa 20
<210> 2868
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2868
gaaaatgacc aactcactgg 20
<210> 2869
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2869
ggccctgttc aaacactata 20
<210> 2870
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2870
tcaggaggcc cttcaagctc 20
<210> 2871
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2871
aacatcgcca ttcccagagt 20
<210> 2872
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2872
ccgtgtcctc acacgctcct 20
<210> 2873
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2873
gaggcggtac atccacgggc 20
<210> 2874
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2874
gcagacgcat ccatttcctc 20
<210> 2875
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2875
acagcaaaca gcccagggtc 20
<210> 2876
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2876
agggcactca cctggatcgc 20
<210> 2877
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2877
cccaacttcc actttgcaaa 20
<210> 2878
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2878
cgtgtggtcc ccctcgccac 20
<210> 2879
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2879
tccctgtcca cacagggtca 20
<210> 2880
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2880
atatggctcc tactccacct 20
<210> 2881
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2881
cccataggtc aaaaagggcc 20
<210> 2882
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2882
cgaggcataa acacacttac 20
<210> 2883
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2883
accctgcttt cagctgggcc 20
<210> 2884
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2884
tcactaggcc tccatgcacc 20
<210> 2885
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2885
ccctaaacca ccactgcccc 20
<210> 2886
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2886
tctctggcca ccacaaggct 20
<210> 2887
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2887
gccacagatt ataacccaca 20
<210> 2888
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2888
gacaagagaa catctgtgcc 20
<210> 2889
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2889
ctcagcgaac ttaattatat 20
<210> 2890
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2890
ccctccccac ctactgcgga 20
<210> 2891
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2891
tcaaactctc ctagtgggtt 20
<210> 2892
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2892
cagatcttca tagcaaccca 20
<210> 2893
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2893
ggcacttcca ccttacccag 20
<210> 2894
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2894
ggcacacaac ccatgtgccc 20
<210> 2895
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2895
cccaagtccc ataagatgct 20
<210> 2896
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2896
tgccggaatc ctcaccctta 20
<210> 2897
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2897
gcagacagcc gacccagcct 20
<210> 2898
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2898
tgggctgtca ttacagtgtg 20
<210> 2899
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2899
ggctgtgaca cccagtgggt 20
<210> 2900
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2900
cccagaggca ccagcgggta 20
<210> 2901
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2901
acatgcgcac agaaatgaac 20
<210> 2902
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2902
ggcagagtgc ctactgcgca 20
<210> 2903
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2903
ctccactgcc ttgccacaca 20
<210> 2904
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2904
ggtgaatcaa agccaagccg 20
<210> 2905
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2905
agaaagccaa ttccagctca 20
<210> 2906
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2906
gcgccctgcc ccagacgcac 20
<210> 2907
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2907
cctctgagtc tccttcgggc 20
<210> 2908
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2908
ggctcaccca ccgtgatgat 20
<210> 2909
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2909
ccagactcac ccaaccctac 20
<210> 2910
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2910
tgtggctctc ccttgcagaa 20
<210> 2911
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2911
gacccaccat ctccccagaa 20
<210> 2912
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2912
tgcatctccc gatatagccc 20
<210> 2913
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2913
gtcagcggca tcactgtccc 20
<210> 2914
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2914
gcaggtgcct tcctttgccg 20
<210> 2915
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2915
ccgaccttta ctccaggcct 20
<210> 2916
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2916
cagcccaccc cagatggtcc 20
<210> 2917
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2917
gtgggcccca cctctgtccg 20
<210> 2918
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2918
catgcatccc ccgacataca 20
<210> 2919
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2919
accccagcac atcctggcct 20
<210> 2920
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2920
tcccagaccc ctcaccaaac 20
<210> 2921
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2921
gcaccaccac aaaaaggaga 20
<210> 2922
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2922
gggagatgcc tcccacttcc 20
<210> 2923
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2923
cccatggtgc ttcctagggc 20
<210> 2924
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2924
gcttcaggcc tttcgcacac 20
<210> 2925
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2925
agcagctgac tctcccgccc 20
<210> 2926
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2926
aattgctaaa ccacactttt 20
<210> 2927
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2927
accatcgccc cacactccac 20
<210> 2928
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2928
ccctctcatc ctatagacac 20
<210> 2929
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2929
agctccatta cctctgctct 20
<210> 2930
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2930
tgaccagacc ccagaatctc 20
<210> 2931
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2931
agacatcccc accgcaaccc 20
<210> 2932
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2932
gctccagcct ttccgtggac 20
<210> 2933
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2933
cgctgtctaa tcagctccca 20
<210> 2934
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2934
atattcaatc aacttaggac 20
<210> 2935
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2935
tgaaagaccc tctctggtct 20
<210> 2936
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2936
gcatgtcacc ccaccagcag 20
<210> 2937
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2937
cctgccagaa cttttggaca 20
<210> 2938
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2938
gggtcagccc acaagcctca 20
<210> 2939
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2939
gaagactccc ctgagcctct 20
Claims (54)
12 내지 50개의 연결된 뉴클레오사이드로 이루어진 변형된 올리고뉴클레오타이드를 포함하는 올리고머 화합물로서, 상기 변형된 올리고뉴클레오타이드의 핵염기 서열은 KCNT1(potassium sodium-activated channel subfamily T member 1) 핵산의 동일한 길이 부분과 적어도 90% 상보성이고, 상기 변형된 올리고뉴클레오타이드는 변형된 당 모이어티 및 변형된 뉴클레오사이드간 링키지(internucleoside linkage)로부터 선택된 적어도 하나의 변형을 포함하는, 올리고머 화합물.
변형된 올리고뉴클레오타이드를 포함하는 올리고머 화합물로서, 상기 변형된 올리고뉴클레오타이드는 12 내지 50개의 연결된 뉴클레오사이드로 이루어지고, 서열번호 21 내지 2939 중 어느 것의 적어도 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 또는 20개의 인접한 핵염기를 포함하는 핵염기 서열을 갖는, 올리고머 화합물.
변형된 올리고뉴클레오타이드를 포함하는 올리고머 화합물로서, 상기 변형된 올리고뉴클레오타이드는 12 내지 50개의 연결된 뉴클레오사이드로 이루어지고,
서열번호 2의 핵염기 24523 내지 24561의 동일한 길이 부분,
서열번호 2의 핵염기 27568 내지 27603의 동일한 길이 부분,
서열번호 2의 핵염기 30772 내지 30811의 동일한 길이 부분,
서열번호 2의 핵염기 54372 내지 54428의 동일한 길이 부분,
서열번호 2의 핵염기 55785 내지 55818의 동일한 길이 부분,
서열번호 2의 핵염기 56048 내지 56073의 동일한 길이 부분,
서열번호 2의 핵염기 56319 내지 56349의 동일한 길이 부분,
서열번호 2의 핵염기 57683 내지 57710의 동일한 길이 부분,
서열번호 2의 핵염기 61117 내지 61153의 동일한 길이 부분,
서열번호 2의 핵염기 71033 내지 71060의 동일한 길이 부분,
서열번호 2의 핵염기 87135 내지 87174의 동일한 길이 부분,
서열번호 2의 핵염기 92109 내지 92149의 동일한 길이 부분,
서열번호 2의 핵염기 94221 내지 94280의 동일한 길이 부분,
서열번호 2의 핵염기 94352 내지 94380의 동일한 길이 부분,
서열번호 2의 핵염기 94993 내지 95036의 동일한 길이 부분,
서열번호 2의 핵염기 95074 내지 95144의 동일한 길이 부분과 상보성인 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 적어도 17개, 적어도 18개, 적어도 19개 또는 적어도 20개의 인접한 핵염기를 포함하는 핵염기 서열을 갖는, 올리고머 화합물.
서열번호 2의 핵염기 24523 내지 24561의 동일한 길이 부분,
서열번호 2의 핵염기 27568 내지 27603의 동일한 길이 부분,
서열번호 2의 핵염기 30772 내지 30811의 동일한 길이 부분,
서열번호 2의 핵염기 54372 내지 54428의 동일한 길이 부분,
서열번호 2의 핵염기 55785 내지 55818의 동일한 길이 부분,
서열번호 2의 핵염기 56048 내지 56073의 동일한 길이 부분,
서열번호 2의 핵염기 56319 내지 56349의 동일한 길이 부분,
서열번호 2의 핵염기 57683 내지 57710의 동일한 길이 부분,
서열번호 2의 핵염기 61117 내지 61153의 동일한 길이 부분,
서열번호 2의 핵염기 71033 내지 71060의 동일한 길이 부분,
서열번호 2의 핵염기 87135 내지 87174의 동일한 길이 부분,
서열번호 2의 핵염기 92109 내지 92149의 동일한 길이 부분,
서열번호 2의 핵염기 94221 내지 94280의 동일한 길이 부분,
서열번호 2의 핵염기 94352 내지 94380의 동일한 길이 부분,
서열번호 2의 핵염기 94993 내지 95036의 동일한 길이 부분,
서열번호 2의 핵염기 95074 내지 95144의 동일한 길이 부분과 상보성인 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 적어도 17개, 적어도 18개, 적어도 19개 또는 적어도 20개의 인접한 핵염기를 포함하는 핵염기 서열을 갖는, 올리고머 화합물.
변형된 올리고뉴클레오타이드를 포함하는 올리고머 화합물로서, 상기 변형된 올리고뉴클레오타이드는 12 내지 50개의 연결된 뉴클레오사이드로 이루어지고,
서열번호 2의 핵염기 16586 내지 16649의 동일한 길이 부분,
서열번호 2의 핵염기 16586 내지 17823의 동일한 길이 부분,
서열번호 2의 핵염기 16586 내지 18663의 동일한 길이 부분,
서열번호 2의 핵염기 19220 내지 20568의 동일한 길이 부분,
서열번호 2의 핵염기 23003 내지 25391의 동일한 길이 부분,
서열번호 2의 핵염기 27095 내지 29908의 동일한 길이 부분,
서열번호 2의 핵염기 30452 내지 30891의 동일한 길이 부분,
서열번호 2의 핵염기 31773 내지 34427의 동일한 길이 부분,
서열번호 2의 핵염기 38458 내지 47003의 동일한 길이 부분,
서열번호 2의 핵염기 40432 내지 42873의 동일한 길이 부분,
서열번호 2의 핵염기 44414 내지 45718의 동일한 길이 부분,
서열번호 2의 핵염기 52096 내지 52153의 동일한 길이 부분,
서열번호 2의 핵염기 52096 내지 58525의 동일한 길이 부분,
서열번호 2의 핵염기 59308 내지 61697의 동일한 길이 부분,
서열번호 2의 핵염기 60111 내지 61697의 동일한 길이 부분,
서열번호 2의 핵염기 65270 내지 67169의 동일한 길이 부분,
서열번호 2의 핵염기 65270 내지 67150의 동일한 길이 부분,
서열번호 2의 핵염기 67026 내지 67065의 동일한 길이 부분,
서열번호 2의 핵염기 67026 내지 67087의 동일한 길이 부분,
서열번호 2의 핵염기 67648 내지 68527의 동일한 길이 부분,
서열번호 2의 핵염기 67955 내지 67998의 동일한 길이 부분,
서열번호 2의 핵염기 68515 내지 68583의 동일한 길이 부분,
서열번호 2의 핵염기 68538 내지 68592의 동일한 길이 부분,
서열번호 2의 핵염기 68571 내지 70874의 동일한 길이 부분,
서열번호 2의 핵염기 71037 내지 71313의 동일한 길이 부분,
서열번호 2의 핵염기 71037 내지 71184의 동일한 길이 부분,
서열번호 2의 핵염기 72851 내지 72887의 동일한 길이 부분,
서열번호 2의 핵염기 79368 내지 79483의 동일한 길이 부분,
서열번호 2의 핵염기 86554 내지 90150의 동일한 길이 부분,
서열번호 2의 핵염기 88332 내지 88448의 동일한 길이 부분,
서열번호 2의 핵염기 91686 내지 95485의 동일한 길이 부분,
서열번호 2의 핵염기 91686 내지 94431의 동일한 길이 부분 또는
서열번호 2의 핵염기 94219 내지 94275의 동일한 길이 부분과 상보성인 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 적어도 17개, 적어도 18개, 적어도 19개 또는 적어도 20개의 인접한 핵염기를 포함하는 핵염기 서열을 갖는, 올리고머 화합물.
서열번호 2의 핵염기 16586 내지 16649의 동일한 길이 부분,
서열번호 2의 핵염기 16586 내지 17823의 동일한 길이 부분,
서열번호 2의 핵염기 16586 내지 18663의 동일한 길이 부분,
서열번호 2의 핵염기 19220 내지 20568의 동일한 길이 부분,
서열번호 2의 핵염기 23003 내지 25391의 동일한 길이 부분,
서열번호 2의 핵염기 27095 내지 29908의 동일한 길이 부분,
서열번호 2의 핵염기 30452 내지 30891의 동일한 길이 부분,
서열번호 2의 핵염기 31773 내지 34427의 동일한 길이 부분,
서열번호 2의 핵염기 38458 내지 47003의 동일한 길이 부분,
서열번호 2의 핵염기 40432 내지 42873의 동일한 길이 부분,
서열번호 2의 핵염기 44414 내지 45718의 동일한 길이 부분,
서열번호 2의 핵염기 52096 내지 52153의 동일한 길이 부분,
서열번호 2의 핵염기 52096 내지 58525의 동일한 길이 부분,
서열번호 2의 핵염기 59308 내지 61697의 동일한 길이 부분,
서열번호 2의 핵염기 60111 내지 61697의 동일한 길이 부분,
서열번호 2의 핵염기 65270 내지 67169의 동일한 길이 부분,
서열번호 2의 핵염기 65270 내지 67150의 동일한 길이 부분,
서열번호 2의 핵염기 67026 내지 67065의 동일한 길이 부분,
서열번호 2의 핵염기 67026 내지 67087의 동일한 길이 부분,
서열번호 2의 핵염기 67648 내지 68527의 동일한 길이 부분,
서열번호 2의 핵염기 67955 내지 67998의 동일한 길이 부분,
서열번호 2의 핵염기 68515 내지 68583의 동일한 길이 부분,
서열번호 2의 핵염기 68538 내지 68592의 동일한 길이 부분,
서열번호 2의 핵염기 68571 내지 70874의 동일한 길이 부분,
서열번호 2의 핵염기 71037 내지 71313의 동일한 길이 부분,
서열번호 2의 핵염기 71037 내지 71184의 동일한 길이 부분,
서열번호 2의 핵염기 72851 내지 72887의 동일한 길이 부분,
서열번호 2의 핵염기 79368 내지 79483의 동일한 길이 부분,
서열번호 2의 핵염기 86554 내지 90150의 동일한 길이 부분,
서열번호 2의 핵염기 88332 내지 88448의 동일한 길이 부분,
서열번호 2의 핵염기 91686 내지 95485의 동일한 길이 부분,
서열번호 2의 핵염기 91686 내지 94431의 동일한 길이 부분 또는
서열번호 2의 핵염기 94219 내지 94275의 동일한 길이 부분과 상보성인 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 적어도 17개, 적어도 18개, 적어도 19개 또는 적어도 20개의 인접한 핵염기를 포함하는 핵염기 서열을 갖는, 올리고머 화합물.
제1항 내지 제4항 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오타이드는 변형된 올리고뉴클레오타이드의 전체 핵염기 서열에 걸쳐서 측정되는 경우 서열번호 1 내지 3으로부터 선택된 핵염기 서열의 동일한 길이 부분과 적어도 80%, 85%, 90%, 95% 또는 100% 상보성인 핵염기를 갖는, 올리고머 화합물.
제1항 내지 제5항 중 어느 한 항에 있어서, 적어도 하나의 변형된 뉴클레오사이드는 변형된 당 모이어티를 포함하는, 올리고머 화합물.
제6항에 있어서, 상기 변형된 당 모이어티는 이환식 당 모이어티를 포함하는, 올리고머 화합물.
제7항에 있어서, 상기 이환식 당 모이어티는 -O-CH2-; 및 -O-CH(CH3)-로부터 선택된 2'-4' 브리지를 포함하는, 올리고머 화합물.
제6항에 있어서, 상기 변형된 당 모이어티는 비-이환식 변형된 당 모이어티를 포함하는, 올리고머 화합물.
제9항에 있어서, 상기 비-이환식 변형된 당 모이어티는 2'-MOE 당 모이어티 또는 2'-OMe 당 모이어티를 포함하는, 올리고머 화합물.
제1 내지 제5항 중 어느 한 항에 있어서, 적어도 하나의 변형된 뉴클레오사이드는 당 대용체를 포함하는, 올리고머 화합물.
제11항에 있어서, 상기 당 대용체는 몰폴리노 및 PNA로부터 선택되는, 올리고머 화합물.
제1항 내지 제12항 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오타이드는,
1 내지 5개의 연결된 5'-영역 뉴클레오사이드로 이루어진 5'-영역;
6 내지 10개의 연결된 중심 영역 뉴클레오사이드로 이루어진 중심 영역; 및
1 내지 5개의 연결된 3'-영역 뉴클레오사이드로 이루어진 3'-영역을 포함하되;
상기 5'-영역 뉴클레오사이드 각각 및 상기 3'-영역 뉴클레오사이드 각각은 변형된 당 모이어티를 포함하고, 상기 중심 영역 뉴클레오사이드 각각은 비변형된 2'-데옥시리보실 당 모이어티를 포함하는, 올리고머 화합물.
1 내지 5개의 연결된 5'-영역 뉴클레오사이드로 이루어진 5'-영역;
6 내지 10개의 연결된 중심 영역 뉴클레오사이드로 이루어진 중심 영역; 및
1 내지 5개의 연결된 3'-영역 뉴클레오사이드로 이루어진 3'-영역을 포함하되;
상기 5'-영역 뉴클레오사이드 각각 및 상기 3'-영역 뉴클레오사이드 각각은 변형된 당 모이어티를 포함하고, 상기 중심 영역 뉴클레오사이드 각각은 비변형된 2'-데옥시리보실 당 모이어티를 포함하는, 올리고머 화합물.
제1항 내지 제13항 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오타이드는 적어도 하나의 변형된 뉴클레오사이드간 링키지를 포함하는, 올리고머 화합물.
제14항에 있어서, 상기 변형된 올리고뉴클레오타이드의 각각의 뉴클레오사이드간 링키지는 변형된 뉴클레오사이드간 링키지인, 올리고머 화합물.
제14항 또는 제15항에 있어서, 상기 변형된 뉴클레오사이드간 링키지는 포스포로티오에이트 뉴클레오사이드간 링키지인, 올리고머 화합물.
제14항 또는 제16항에 있어서, 상기 변형된 올리고뉴클레오타이드는 적어도 하나의 포스포다이에스터 뉴클레오사이드간 링키지를 포함하는, 올리고머 화합물.
제14항, 제16항 및 제17항 중 어느 한 항에 있어서, 뉴클레오사이드간 링키지 각각은 포스포다이에스터 뉴클레오사이드간 링키지 또는 포스포로티오에이트 뉴클레오사이드간 링키지로부터 독립적으로 선택되는, 올리고머 화합물.
제1항 내지 제18항 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오타이드는 적어도 하나의 변형된 핵염기를 포함하는, 올리고머 화합물.
제19항에 있어서, 상기 변형된 핵염기는 5-메틸 사이토신인, 올리고머 화합물.
제1항 내지 제20항 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오타이드는 12 내지 30개, 12 내지 22개, 12 내지 20개, 14 내지 20개, 15 내지 25개, 16 내지 20개, 18 내지 22개 또는 18 내지 20개의 연결된 뉴클레오사이드로 이루어지는, 올리고머 화합물.
제1항 내지 제21항 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오타이드는 20개의 연결된 뉴클레오사이드로 이루어지는, 올리고머 화합물.
제22항에 있어서, 상기 변형된 올리고뉴클레오타이드는 뉴클레오사이드간 링키지 모티프 soooossssssssssooss를 가지며, "s"는 포스포로티오에이트 뉴클레오사이드간 링키지를 나타내고, "o"는 포스포다이에스터 뉴클레오사이드간 링키지를 나타내는, 올리고머 화합물.
제1항 내지 제23항 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오타이드로 이루어진 올리고머 화합물.
제1항 내지 제23항 중 어느 한 항에 있어서, 접합체 모이어티 및 접합체 링커를 포함하는 접합체 기를 포함하는 올리고머 화합물.
제25항에 있어서, 상기 접합체 기는 1 내지 3개의 GalNAc 리간드를 포함하는 GalNAc 클러스터를 포함하는, 올리고머 화합물.
제25항 또는 제26항에 있어서, 상기 접합체 링커는 단일 결합으로 이루어진, 올리고머 화합물.
제25항에 있어서, 상기 접합체 링커는 절단 가능한, 올리고머 화합물.
제28항에 있어서, 상기 접합체 링커는 1 내지 3개의 링커-뉴클레오사이드를 포함하는, 올리고머 화합물.
제25항 내지 제29항 중 어느 한 항에 있어서, 상기 접합체 기는 상기 변형된 올리고뉴클레오타이드의 5'-단부에서 상기 변형된 올리고뉴클레오타이드에 접합되어 있는, 올리고머 화합물.
제25항 내지 제29항 중 어느 한 항에 있어서, 상기 접합체 기는 상기 변형된 올리고뉴클레오타이드의 3'-단부에서 상기 변형된 올리고뉴클레오타이드에 접합되어 있는, 올리고머 화합물.
제1항 내지 제31항 중 어느 한 항에 있어서, 말단 기를 포함하는 올리고머 화합물.
제1항 내지 제32항 중 어느 한 항에 있어서, 상기 올리고머 화합물은 단일-가닥 올리고머 화합물인, 올리고머 화합물.
제1항 내지 제28항, 제30항 및 제31항 중 어느 한 항에 있어서, 상기 올리고머 화합물은 링커-뉴클레오사이드를 포함하지 않는, 올리고머 화합물.
제1항 내지 제34항 중 어느 한 항에 있어서, 상기 올리고머 화합물의 상기 변형된 올리고뉴클레오타이드는 염이며, 상기 염은 나트륨염 또는 칼륨염인, 올리고머 화합물.
제1항 내지 제32항, 제34항 및 제35항 중 어느 한 항의 올리고머 화합물을 포함하는 올리고머 듀플렉스.
제1항 내지 제35항 중 어느 한 항의 올리고머 화합물 또는 제36항의 올리고머 듀플렉스를 포함하거나 또는 이들로 이루어진 안티센스 화합물.
제1항 내지 제35항 중 어느 한 항의 올리고머 화합물 또는 제36항의 올리고머 듀플렉스 및 약제학적으로 허용 가능한 담체 또는 희석제를 포함하는 약제학적 조성물.
제38항에 있어서, 상기 약제학적으로 허용 가능한 희석제는 인공 척수액 또는 PBS인, 약제학적 조성물.
제39항에 있어서, 상기 약제학적 조성물은 상기 변형된 올리고뉴클레오타이드 및 인공 척수액으로 본질적으로 이루어진, 약제학적 조성물.
대상체에게 제38항 내지 제40항 중 어느 한 항의 약제학적 조성물을 투여하는 단계를 포함하는 방법.
신경학적 병태의 치료 방법으로서, 상기 신경학적 병태를 갖거나 이의 발병 위험이 있는 개체에게 치료적 유효량의 제38항 내지 제40항 중 어느 한 항의 약제학적 조성물을 투여하는 단계; 및 이에 의해서 상기 신경학적 병태를 치료하는 단계를 포함하는 방법.
신경학적 병태를 갖거나 이의 발병 위험이 있는 개체의 중추 신경계에서 KCNT1 RNA 또는 KCNT1 단백질을 감소시키는 방법으로서, 치료적 유효량의 제38항 내지 제40항 중 어느 한 항에 따른 약제학적 조성물을 투여하는 단계; 및 이에 의해서 상기 중추 신경계에서 KCNT1 RNA 또는 KCNT1 단백질을 감소시키는 단계를 포함하는 방법.
제42항 또는 제43항에 있어서, 상기 신경학적 병태는 뇌병증을 포함하는, 방법.
제42항 또는 제43항에 있어서, 상기 신경학적 병태는 뇌전증을 포함하는, 방법.
제42항 또는 제43항에 있어서, 상기 신경학적 병태는 영아 뇌전증을 포함하는, 방법.
제46항에 있어서, 상기 영아 뇌전증은 이동성 초점성 발작을 동반한 유아기의 뇌전증(epilepsy of infancy with migrating focal seizure: EIMFS)인, 방법.
제42항 또는 제43항에 있어서, 상기 신경학적 병태는 상염색체 우성 야간 전두엽 간질(autosomal dominant nocturnal frontal lobe epilepsy: ADNFLE)인, 방법.
제41항 내지 제48항 중 어느 한 항에 있어서, 상기 투여는 척추강내 투여에 의한 것인, 방법.
제42항 내지 제49항 중 어느 한 항에 있어서, 상기 신경학적 병태 중 적어도 하나의 증상 또는 특징이 개선되는, 방법.
제50항에 있어서, 상기 증상 또는 특징은 발작, 뇌 손상, 탈수초, 근기능 저하, 소두증, 우울증, 불안, 인지 기능으로부터 선택되는, 방법.
제42항 내지 제51항 중 어느 한 항에 있어서, 상기 방법은 질환 퇴행을 예방하거나 둔화시키는, 방법.
세포에서 KCNT1 RNA를 감소시키는 방법으로서, 상기 세포를 제1항 내지 제35항 중 어느 한 항에 따른 올리고머 화합물, 제36항에 따른 올리고머 듀플렉스 또는 제37항에 따른 안티센스 화합물과 접촉시키는 단계; 및 이에 의해서 상기 세포에서 KCNT1 RNA를 감소시키는 단계를 포함하는 방법.
세포에서 KCNT1 단백질을 감소시키는 방법으로서, 상기 세포를 제1항 내지 제35항 중 어느 한 항에 따른 올리고머 화합물, 제36항에 따른 올리고머 듀플렉스 또는 제37항에 따른 안티센스 화합물과 접촉시키는 단계; 및 이에 의해서 상기 세포에서 KCNT1 단백질을 감소시키는 단계를 포함하는 방법.
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