KR20210141983A - Compounds and methods for reducing KCNT1 expression - Google Patents

Abstract

Provided are compounds, methods, and pharmaceutical compositions for reducing the amount or activity of KCNT1 RNA in a cell or subject, and in certain instances, reducing the amount of KCNT1 protein in a cell or subject. Such compounds, methods and pharmaceutical compositions are useful for ameliorating at least one symptom or characteristic of a neurological condition. These symptoms and features include seizures, encephalopathy, and behavioral abnormalities. Non-limiting examples of neurological conditions that may benefit from such compounds, methods and pharmaceutical compositions include childhood epilepsy with migratory focal seizures (EIMFS), autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), West syndrome and Otahara Syndrome.

Description

Compounds and methods for reducing KCNT1 expression

sequence list

This application is filed with a sequence listing in electronic format. The above sequence listing is provided in the file name of BIOL0358WOSEQ_ST25.txt, which is 716kb in size and dated March 9, 2020. Information in this electronic format of the Sequence Listing is incorporated herein by reference in its entirety.

technical field

A compound for reducing the amount of potassium sodium-activated channel subfamily T member 1 (KCNT1) RNA in a cell or subject, and in certain instances, reducing the amount of KCNT1 protein in a cell or subject , methods and pharmaceutical compositions are provided. Such compounds, methods and pharmaceutical compositions are useful for ameliorating at least one symptom or characteristic of a neurological condition. Such symptoms and features include, but are not limited to, encephalopathy, cerebral cortical atrophy, clonus, seizures (epilepsy), and behavioral abnormalities such as aggression, catatonia, psychosis and intellectual disability. Non-limiting examples of neurological conditions that can be treated with the compounds, methods, and pharmaceutical compositions disclosed herein include epilepsy of infancy with migrating focal seizures (EIMFS), autosomal autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), and early onset epileptic encephalopathy, including West syndrome and Ohtahara syndrome.

Epilepsy is a neurological disorder characterized by periodic abnormalities in brain activity. As a non-limiting example, individuals with epilepsy often exhibit abnormal behavior such as seizures (convulsions or tremors of an uncontrollable extremity), loss of consciousness, catatonic confusion, and psychosis. Epileptic individuals may experience focal seizures or generalized seizures. Focal seizures affect specific areas of the brain. In contrast, generalized seizures affect all areas of the brain. Tragically, the onset of epilepsy can occur within the first few months of life, as seen in patients with EIMFS and in patients with infantile epileptic encephalopathy (EIEE). EIMFS is a severe drug-resistant epilepsy with high sudden and unexpected mortality in epilepsy. The onset of seizures in EIMFS subjects often occurs during the first months of life.

KCNT1, also known as Sequence Like a Calcium Activated K+ channel (SLACK), K _Ca 4.1 and Slo2.2, forms a tetrameric channel with KCNT2 to form sodium-sensitive potassium currents in a diverse range of neurons. It is a sodium-gated potassium channel subunit that mediates Two splice isoforms of KCNT1 mRNA are expressed in humans. These isoforms can produce different proteins with different electrophysical properties similar to the SLACK isoform variants found in rodents.

Acquisition of functional mutations in KCNT1 can lead to several types of epilepsy, including ADNFLE and EIMFS. To date, all KCNT1 mutations found in epileptic subjects are missense mutations that result in KCNT1 protein gain function. These missense mutations increase potassium channel activity and increase maximal potassium current. Approximately 42-50% of EIMFS cases are due to KCNT1 acquisition of a function mutation.

Currently, there is a lack of acceptable options for treating infantile encephalopathy and epilepsy. Accordingly, these conditions have significant unmet needs. In addition, there are many cases of drug-resistant epilepsy, with patients having little or no treatment options. Accordingly, it is an object of the present specification to provide compounds, methods and pharmaceutical compositions for treating such diseases.

Provided herein are compounds, methods, and pharmaceutical compositions for reducing the amount or activity of KCNT1 RNA, and in certain embodiments, for reducing the activity of KCNT1 protein in a cell or subject. In certain embodiments the subject is a human infant. In certain embodiments, the subject has a neurological condition. In certain embodiments, the neurological condition comprises encephalopathy. In certain embodiments, the neurological condition comprises epilepsy. In certain embodiments, the neurological condition is EIMFS. In certain embodiments, the neurological condition is ADNFLE. In certain embodiments, compounds useful for reducing the amount or activity of KCNT1 RNA are oligomeric compounds. In certain embodiments, compounds useful for reducing the expression of KCNT1 RNA are modified oligonucleotides.

Also provided herein are methods useful for ameliorating at least one symptom or characteristic of a neurological condition. In certain embodiments, the neurological condition is EIMFS. In certain embodiments, the neurological condition is ADNFLE. In certain embodiments, the at least one symptom or characteristic is selected from seizures, brain damage, demyelination, hypotonia, microcephaly, depression, anxiety, cognitive function. In certain embodiments, the methods disclosed herein are useful for reducing the incidence of seizures. In certain embodiments, the methods disclosed herein are useful for reducing seizure severity.

It is to be understood that the foregoing general description and the following detailed description are for purposes of illustration and description only and are not limiting. In this specification, the use of the singular includes the plural unless specifically stated otherwise. As used herein, the use of "or" means "and/or" unless stated otherwise. Moreover, use of the term “comprising” as well as other forms such as “comprises” and “included” is not limiting. Also, terms such as "element" or "component" include both elements and components comprising one unit and elements and components comprising one or more subunits, unless specifically stated otherwise.

Section headings used herein are for structuring purposes only and should not be construed as limiting the subject matter described. All documents or portions of documents cited in this application, including but not limited to patents, patent applications, articles, books and articles, as well as portions of documents discussed herein, are expressly incorporated herein by reference in their entirety. Included.

Justice

Unless specific definitions are provided, the nomenclature used in connection with the subject matter described herein, and the procedures and techniques of analytical chemistry, synthetic organic chemistry, and drug and pharmaceutical chemistry described herein, are well known and routinely used in the art. will be used as To the extent permissible, all patents, applications, published applications and other publications and other data referenced throughout the disclosure are hereby incorporated by reference in their entirety.

Unless otherwise indicated, the following terms have the following meanings:

Justice

As used herein, "2'-deoxynucleoside" refers to a nucleoside comprising a 2'-H(H) deoxyribosyl sugar moiety. In certain embodiments, the 2'-deoxynucleoside is a 2'-β-D-deoxynucleoside and is a 2' with the β-D configuration as found in naturally occurring deoxyribonucleic acids (DNA). -β-D-deoxyribosyl sugar moiety. In certain embodiments, a 2'-deoxynucleoside or nucleoside comprising an unmodified 2'-deoxyribosyl sugar moiety may comprise a modified nucleobase or an RNA nucleobase (uracil) ) may be included.

As used herein, "2'-MOE" or "2'-MOE sugar moiety" refers to 2'-OCH ₂ CH ₂ OCH ₃ in place of the 2'-OH group of the ribosyl sugar moiety. "MOE" means methoxyethyl.

As used herein, "2'-MOE nucleoside" refers to a nucleoside comprising a 2'-MOE sugar moiety.

As used herein, "2'-OMe" or "2'-O-methyl sugar moiety" refers to a 2'-OCH ₃ group in place of the 2'-OH group of a ribosyl sugar moiety.

As used herein, "2'-OMe nucleoside" refers to a nucleoside comprising a 2'-OMe sugar moiety.

As used herein, "2'-substituted nucleoside" refers to a nucleoside comprising a 2'-substituted sugar moiety. As used herein, "2'-substituted" in reference to a sugar moiety means a sugar moiety comprising at least one 2'-substituent other than H or OH.

As used herein, "5-methyl cytosine" refers to a cytosine modified with a methyl group attached to the 5 position. 5-Methyl cytosine is a modified nucleobase.

As used herein, "administering" means providing a pharmaceutical agent to a subject.

As used herein, "antisense activity" refers to any detectable and/or measurable change due to hybridization of an antisense compound to its target nucleic acid. In certain embodiments, antisense activity is a decrease in the amount or expression of a target nucleic acid or protein encoded by such a target nucleic acid compared to the level of the target nucleic acid or target protein in the absence of the antisense compound.

As used herein, "antisense compound" means an oligomeric compound capable of achieving at least one antisense activity.

As used herein, "ameliorate" in reference to treatment means that at least one symptom is ameliorated as compared to the same symptom in the absence of treatment. In certain embodiments, the amelioration is a decrease in the severity or frequency of symptoms or delay onset or slowing of the progression of the severity or frequency of symptoms.

As used herein, "bicyclic nucleoside" or "BNA" refers to a nucleoside comprising a bicyclic sugar moiety.

As used herein, "bicyclic sugar" or "bicyclic sugar moiety" refers to a modified sugar moiety comprising two rings, wherein the second ring comprises two of the atoms in the first ring. They are formed through connecting bridges to form a bicyclic structure. In certain embodiments, the first ring of the bicyclic sugar moiety is a furanosyl moiety. In certain embodiments, the bicyclic sugar moiety does not comprise a furanosyl moiety.

As used herein, "cleavable moiety" refers to a bond or group of atoms that are cleaved under physiological conditions, eg, in a cell or subject.

As used herein, "complementarity" in reference to an oligonucleotide refers to a nucleobase of an oligonucleotide or one or more regions thereof and another nucleic acid or means that at least 70% of the nucleobases of one or more regions thereof are capable of hydrogen bonding to each other. As used herein, "complementary nucleobases" means nucleobases capable of forming hydrogen bonds with each other. Complementary nucleobase pairs are adenine (A) and thymine (T), adenine (A) and uracil (U), cytosine (C) and guanine (G), 5-methyl cytosine (mC) and guanine (G) includes Complementary oligonucleotides and/or nucleic acids need not have nucleobase complementarity at each nucleoside. Rather, some mismatch is tolerated. As used herein, "fully complementary" or "100% complementarity" in reference to an oligonucleotide means that at each nucleoside of the oligonucleotide is complementary to another oligonucleotide or nucleic acid.

As used herein, "conjugate group" refers to a group of atoms attached directly or indirectly to an oligonucleotide. Conjugate groups include a conjugate moiety and a conjugate linker that attaches the conjugate moiety to the oligonucleotide.

As used herein, "conjugate linker" refers to a group of atoms comprising at least one bond linking a conjugate moiety to an oligonucleotide.

As used herein, "conjugate moiety" refers to a group of atoms attached to an oligonucleotide through a conjugate linker.

As used herein, "adjacent" in the context of an oligonucleotide refers to a nucleoside, a nucleobase, a sugar moiety, or an internucleoside linkage in immediate proximity to each other. For example, "contiguous nucleobases" means nucleobases that are immediately adjacent to each other in sequence.

As used herein, “constrained ethyl” or “cEt” or “cEt modified sugar” refers to a β-D ribosyl bicyclic sugar moiety, wherein the second ring of the bicyclic sugar is β -D is formed via a bridge connecting the 4'-carbon and 2'-carbon of the ribosyl sugar moiety, the bridge has the formula 4'-CH(CH ₃ )-O-2', and the methyl group of the bridge is S exists as a boat.

As used herein, "cEt nucleoside" refers to a nucleoside comprising a cEt modified sugar.

As used herein, a "chirally enriched population" means that the number or percentage of molecules in the population that contain a particular stereochemical configuration at a particular chiral center are stereorandom at that particular chiral center. , means a plurality of molecules of the same molecular formula greater than the number or percentage of molecules expected to contain the same specific stereochemical configuration at the same specific chiral center in the population. A population of chirally enriched molecules having multiple chiral centers in each molecule may contain one or more stereorandom chiral centers. In certain embodiments, the molecule is a modified oligonucleotide. In certain embodiments, the molecule is a compound comprising a modified oligonucleotide.

As used herein, a "gapmer" is a modification comprising an inner region having a plurality of nucleosides that supports RNase H cleavage, positioned between outer regions having one or more nucleosides. oligonucleotide, wherein a nucleoside comprising an inner region is chemically distinct from a nucleoside or nucleoside comprising an outer region. The inner region may be referred to as a “gap” and the outer region may be referred to as a “wing”. Unless otherwise indicated, "gammer" refers to a sugar motif. Unless otherwise indicated, the sugar moiety of each nucleoside of the gap of the gapmer is an unmodified 2'-β-D-deoxyribosyl sugar moiety. Thus, the term "MOE gapmer" refers to a gapmer having a gap comprising 2'-β-D-deoxynucleoside and a wing comprising 2'-MOE nucleoside. Unless otherwise indicated, MOE gapmers may comprise one or more modified internucleoside linkages and/or modified nucleobases, such modifications not necessarily following the gapmer pattern of sugar modifications.

As used herein, “hotspot regions” are various nucleobases on a target nucleic acid that are modifiable for an oligomeric compound-mediated decrease in the amount or activity of the target nucleic acid.

As used herein, "hybridization" refers to the pairing or annealing of complementary oligonucleotides and/or nucleic acids. While not wishing to be bound by any particular mechanism, the most common hybridization mechanisms involve hydrogen bonding between complementary nucleobases, which hydrogen bonding may be Watson-Crick, Hoogsteen, or reverse Hoogsteen hydrogen bonding.

As used herein, the term “internucleoside linkage” is a covalent linkage between adjacent nucleosides within an oligonucleotide. As used herein, "modified internucleoside linkage" means any internucleoside linkage other than a phosphodiester internucleoside linkage. A “phosphorothioate internucleoside linkage” is a modified internucleoside linkage in which one of the non-bridging oxygen atoms of the phosphodiester internucleoside linkage is replaced by a sulfur atom.

As used herein, "linker-nucleoside" refers to a nucleoside that directly or indirectly connects an oligonucleotide to a conjugate moiety. The linker-nucleoside is located within the conjugate linker of the oligomeric compound. Linker-nucleosides are not considered part of the oligonucleotide portion of an oligomeric compound, even if they are adjacent to the oligonucleotide.

As used herein, a “non-bicyclic modified sugar moiety” refers to a modified sugar moiety that includes a modification that does not form a second ring by forming a bridge between two atoms of the sugar, such as a substituent. it means.

As used herein, “mismatch” or “non-complementarity” refers to a first oligonucleotide that is not complementary to a corresponding nucleobase of a second oligonucleotide or target nucleic acid when the first oligonucleotide and the second oligonucleotide are aligned. It refers to the nucleobase of an oligonucleotide.

As used herein, "motif" refers to a pattern of unmodified and/or modified sugar moieties, nucleobases and/or internucleoside linkages within an oligonucleotide.

As used herein, “neurological condition” refers to a condition of the brain, central nervous system, peripheral nervous system, or combinations thereof. The neurological condition may be characterized by at least one of nerve dysfunction, nerve damage, and nerve death. The neurological condition may include decreased motor function. The neurological condition may include decreased motor control.

As used herein, "nucleobase" means an unmodified nucleobase or a modified nucleobase. As used herein, an “unmodified nucleobase” is adenine (A), thymine (T), cytosine (C), uracil (U) or guanine (G). As used herein, a "modified nucleobase" is a group of atoms other than an unmodified A, T, C, U or G that can pair with at least one unmodified nucleobase. "5-Methyl cytosine" is a modified nucleobase. A universal base is a modified nucleobase capable of pairing with any of the five unmodified nucleobases. As used herein, "nucleobase sequence" refers to the sequence of contiguous nucleobases within a nucleic acid or oligonucleotide, regardless of any sugar or internucleoside linkage modifications.

As used herein, "nucleoside" refers to a compound comprising a nucleobase and a sugar moiety. The nucleobases and sugar moieties are each independently unmodified or modified. As used herein, "modified nucleoside" refers to a nucleoside comprising a modified nucleobase and/or a modified sugar moiety. Modified nucleosides include abasic nucleosides, which lack a nucleobase. A “linked nucleoside” is a nucleoside that is linked within contiguous sequences (ie, there are no additional nucleosides between the nucleosides being linked).

As used herein, "oligomeric compound" refers to an oligonucleotide and optionally one or more additional features, such as a conjugate group or an end group. The oligomeric compound may or may not pair with a second oligomeric compound that is complementary to the first oligomeric compound. A “single-stranded oligomeric compound” is an unpaired oligomeric compound. The term “oligomeric duplex” refers to a duplex formed by two oligomeric compounds having complementary nucleobase sequences. Each oligomeric compound of an oligomeric duplex may be referred to as a "duplexed oligomeric compound."

As used herein, "oligonucleotide" refers to a strand of linked nucleosides linked through an internucleoside linkage, wherein each nucleoside and internucleoside linkage is modified or unmodified. can be Unless otherwise indicated, oligonucleotides consist of 8 to 50 linked nucleosides. As used herein, "modified oligonucleotide" refers to an oligonucleotide in which at least one nucleoside or internucleoside linkage is modified. As used herein, "unmodified oligonucleotide" refers to an oligonucleotide that does not contain any nucleoside modifications or internucleoside modifications.

As used herein, "pharmaceutically acceptable carrier or diluent" means any substance suitable for use in administration to a subject. These specific carriers enable pharmaceutical compositions to be formulated, for example, into tablets, pills, dragees, capsules, liquids, gels, syrups, slurries, suspensions and lozenges for oral ingestion by a subject. In certain embodiments, the pharmaceutically acceptable carrier or diluent is sterile water, sterile saline, sterile buffer, or sterile artificial cerebrospinal fluid.

As used herein, "pharmaceutically acceptable salt" refers to a physiologically and pharmaceutically acceptable salt of a compound. Pharmaceutically acceptable salts retain the desired biological activity of the parent compound and do not impart undesirable toxicological effects thereto.

As used herein, "pharmaceutical composition" means a mixture of substances suitable for administration to a subject. For example, the pharmaceutical composition may include an oligomeric compound and a sterile aqueous solution. In certain embodiments, the pharmaceutical composition exhibits activity in a free uptake assay in a particular cell line.

As used herein, “prodrug” refers to a form of therapeutic agent outside the body that is converted to a different form within a subject or cells thereof. Typically, conversion of a prodrug in a subject is facilitated by the action of enzymes (eg, endogenous or viral enzymes) present in cells or tissues and/or by physiological conditions.

As used herein, "reducing or inhibiting the amount or activity" refers to the reduction or blockade of transcriptional expression or activity relative to the transcriptional expression or activity in an untreated sample or a control sample, not necessarily transcriptional expression or activity. does not indicate the complete removal of

As used herein, "RNA" refers to an RNA transcript and includes pre-mRNA and mature mRNA, unless otherwise specified.

As used herein, "RNAi compound" refers to an antisense compound that modulates a target nucleic acid and/or a protein encoded by the target nucleic acid by acting, at least in part, through RISC or Ago2. RNAi compounds include, but are not limited to, microRNAs, including double-stranded siRNA, single-stranded RNA (ssRNA), and microRNA mimetics. In certain embodiments, the RNAi compound modulates the amount, activity and/or splicing of a target nucleic acid. The term RNAi compound excludes antisense compounds that act via RNase H.

As used herein, "self-complementarity" in reference to an oligonucleotide means an oligonucleotide that hybridizes at least partially to itself.

As used herein, "standard cell assay" refers to the assay described in Example 1 and valid variations thereof.

As used herein, "stereorandom chiral center" in reference to a population of molecules of the same molecular formula means a chiral center having a random stereochemical configuration. For example, in a population of molecules that contain a stereorandom chiral center, the number of molecules with the (S) configuration of the stereorandom chiral center is equal to the number of molecules with the (R) configuration of the stereorandom chiral center. You can, but not necessarily. A stereochemical configuration of a chiral center is considered random if it is the result of a synthetic method not designed to control the stereochemical configuration. In certain embodiments, the stereorandom chiral center is a stereorandom phosphorothioate internucleoside linkage.

As used herein, "subject" means a human or non-human animal. In certain embodiments, the subject is a human.

As used herein, "sugar moiety" means an unmodified sugar moiety or a modified sugar moiety. As used herein, "unmodified sugar moiety" refers to a 2'-OH(H) ribosyl moiety as found in RNA ("unmodified RNA sugar moiety") or as found in DNA. 2'-H(H) deoxyribosyl moiety (“unmodified DNA sugar moiety”) as defined herein. The unmodified sugar moiety has one hydrogen at the 1', 3', and 4' positions, an oxygen at the 3' position and two hydrogens at the 5' position, respectively. As used herein, "modified sugar moiety" or "modified sugar" refers to a modified furanosyl sugar moiety or sugar surrogate.

As used herein, "sugar surrogate" refers to something other than a furanosyl moiety capable of linking a nucleobase to another group, such as an internucleoside linkage, conjugate group, or terminal group of an oligonucleotide. modified sugar moieties. A modified nucleoside comprising a sugar surrogate may be incorporated at one or more positions within the oligonucleotide, and such oligonucleotide may hybridize to a complementary oligomeric compound or target nucleic acid.

As used herein, “symptom or characteristic” refers to any physical characteristic or test result indicative of the presence or extent of a disease or disorder. In certain embodiments, the symptoms are apparent to the subject or the healthcare professional examining or examining the subject. In certain embodiments, the characteristic is self-evident in an invasive diagnostic test including, but not limited to, a post-mortem test.

As used herein, "target nucleic acid" and "target RNA" refer to a nucleic acid that an antisense compound is designed to affect.

As used herein, "target region" refers to a portion of a target nucleic acid to which an oligomeric compound is designed to hybridize.

As used herein, “terminal group” refers to a chemical group or group of atoms that is covalently linked to the terminus of an oligonucleotide.

As used herein, “therapeutically effective amount” refers to an amount of a pharmaceutical agent that provides a therapeutic benefit to a subject. For example, a therapeutically effective amount ameliorates the symptoms of the disease.

specific embodiment

The present disclosure provides the following non-limiting numbered embodiments:

Embodiment 1. An oligomeric compound comprising a modified oligonucleotide consisting of 12 to 50 linked nucleosides, wherein the nucleobase sequence of the modified oligonucleotide is at least 90% complementary to an identical length portion of a KCNT1 nucleic acid, wherein the modified wherein the modified oligonucleotide comprises at least one modification selected from a modified sugar moiety and a modified internucleoside linkage.

Embodiment 2. An oligomeric compound comprising a modified oligonucleotide, wherein the modified oligonucleotide consists of 12 to 50 linked nucleosides and comprises at least 8, 9, 10, 11, An oligomeric compound having a nucleobase sequence comprising 12, 13, 14, 15, 16, 17, 18, 19 or 20 contiguous nucleobases.

Embodiment 3. An oligomeric compound comprising a modified oligonucleotide, wherein the modified oligonucleotide consists of 12 to 50 linked nucleosides,

The same length portion of nucleobases 24523 to 24561 of SEQ ID NO: 2,

The same length portion of nucleobases 27568 to 27603 of SEQ ID NO: 2,

The same length portion of nucleobases 30772 to 30811 of SEQ ID NO: 2,

The same length portion of nucleobases 54372 to 54428 of SEQ ID NO: 2,

The same length portion of nucleobases 55785 to 55818 of SEQ ID NO: 2,

The same length portion of nucleobases 56048 to 56073 of SEQ ID NO: 2,

The same length portion of nucleobases 56319 to 56349 of SEQ ID NO: 2,

The same length portion of nucleobases 57683 to 57710 of SEQ ID NO: 2,

The same length portion of nucleobases 61117 to 61153 of SEQ ID NO: 2,

The same length portion of nucleobases 71033 to 71060 of SEQ ID NO: 2,

the same length portion of nucleobases 87135-87174 of SEQ ID NO: 2,

the same length portion of nucleobases 92109 to 92149 of SEQ ID NO: 2;

The same length portion of nucleobases 94221 to 94280 of SEQ ID NO: 2,

The same length portion of nucleobases 94352 to 94380 of SEQ ID NO: 2,

the same length portion of nucleobases 94993 to 95036 of SEQ ID NO: 2,

at least 8, at least 9, at least 10, at least 11, at least 12, at least 13, at least 14, at least 15, at least 16 complementary to the same length portion of nucleobases 95074 to 95144 of SEQ ID NO: 2 An oligomeric compound having a nucleobase sequence comprising at least 17, at least 18, at least 19 or at least 20 contiguous nucleobases.

Embodiment 4. An oligomeric compound comprising a modified oligonucleotide, wherein the modified oligonucleotide consists of 12 to 50 linked nucleosides,

the same length portion of nucleobases 16586 to 16649 of SEQ ID NO: 2,

The same length portion of nucleobases 16586 to 17823 of SEQ ID NO: 2,

The same length portion of nucleobases 16586 to 18663 of SEQ ID NO: 2,

The same length portion of nucleobases 19220 to 20568 of SEQ ID NO: 2,

The same length portion of nucleobases 23003 to 25391 of SEQ ID NO: 2,

the same length portion of nucleobases 27095 to 29908 of SEQ ID NO: 2,

The same length portion of nucleobases 30452 to 30891 of SEQ ID NO: 2,

The same length portion of nucleobases 31773 to 34427 of SEQ ID NO: 2,

the same length portion of nucleobases 38458 to 47003 of SEQ ID NO: 2,

The same length portion of nucleobases 40432 to 42873 of SEQ ID NO: 2,

The same length portion of nucleobases 44414 to 45718 of SEQ ID NO: 2,

The same length portion of nucleobases 52096 to 52153 of SEQ ID NO: 2,

the same length portion of nucleobases 52096 to 58525 of SEQ ID NO: 2,

The same length portion of nucleobases 59308 to 61697 of SEQ ID NO: 2,

The same length portion of nucleobases 60111 to 61697 of SEQ ID NO: 2,

The same length portion of nucleobases 65270 to 67169 of SEQ ID NO: 2,

The same length portion of nucleobases 65270 to 67150 of SEQ ID NO: 2,

The same length portion of nucleobases 67026 to 67065 of SEQ ID NO: 2,

The same length portion of nucleobases 67026 to 67087 of SEQ ID NO: 2,

The same length portion of nucleobases 67648 to 68527 of SEQ ID NO: 2,

The same length portion of nucleobases 67955 to 67998 of SEQ ID NO: 2,

The same length portion of nucleobases 68515 to 68583 of SEQ ID NO: 2,

The same length portion of nucleobases 68538 to 68592 of SEQ ID NO: 2,

The same length portion of nucleobases 68571 to 70874 of SEQ ID NO: 2,

The same length portion of nucleobases 71037 to 71313 of SEQ ID NO: 2,

The same length portion of nucleobases 71037 to 71184 of SEQ ID NO: 2,

The same length portion of nucleobases 72851 to 72887 of SEQ ID NO: 2,

The same length portion of nucleobases 79368 to 79483 of SEQ ID NO: 2,

The same length portion of nucleobases 86554 to 90150 of SEQ ID NO: 2,

the same length portion of nucleobases 88332 to 88448 of SEQ ID NO: 2,

The same length portion of nucleobases 91686 to 95485 of SEQ ID NO: 2,

the same length portion of nucleobases 91686 to 94431 of SEQ ID NO: 2 or

at least 8, at least 9, at least 10, at least 11, at least 12, at least 13, at least 14, at least 15, at least 16 complementary to the same length portion of nucleobases 94219 to 94275 of SEQ ID NO:2 An oligomeric compound having a nucleobase sequence comprising at least 17, at least 18, at least 19 or at least 20 contiguous nucleobases.

Embodiment 5. The method according to any one of embodiments 1 to 4, wherein the modified oligonucleotide comprises an equal length portion of a nucleobase sequence selected from SEQ ID NOs: 1 to 3 when measured over the entire nucleobase sequence of the modified oligonucleotide; An oligomeric compound having nucleobases that are at least 80%, 85%, 90%, 95% or 100% complementary.

Embodiment 6. The oligomeric compound of any one of Embodiments 1-5, wherein at least one modified nucleoside comprises a modified sugar moiety.

Embodiment 7. The oligomeric compound of embodiment 6, wherein the modified sugar moiety comprises a bicyclic sugar moiety.

Embodiment 8. The method of embodiment 7, wherein said bicyclic sugar moiety is -O-CH ₂ -; and a 2′-4′ bridge selected from —O—CH(CH _{3 )—.}

Embodiment 9 The oligomeric compound of embodiment 6, wherein the modified sugar moiety comprises a non-bicyclic modified sugar moiety.

Embodiment 10 The oligomeric compound of embodiment 9, wherein the non-bicyclic modified sugar moiety comprises a 2'-MOE sugar moiety or a 2'-OMe sugar moiety.

Embodiment 11 The oligomeric compound of any one of embodiments 1-5, wherein at least one modified nucleoside comprises a sugar surrogate.

Embodiment 12 The oligomeric compound of embodiment 11, wherein the sugar surrogate is selected from morpholino and PNA.

Embodiment 13. The method according to any one of embodiments 1 to 12, wherein the modified oligonucleotide comprises:

a 5'-region consisting of 1 to 5 linked 5'-region nucleosides;

a central region consisting of 6 to 10 linked central region nucleosides; and

a 3'-region consisting of 1 to 5 linked 3'-region nucleosides;

each of the 5'-region nucleosides and each of the 3'-region nucleosides comprises a modified sugar moiety, and each of the central region nucleosides comprises an unmodified 2'-deoxyribosyl sugar moiety. comprising, an oligomeric compound.

Embodiment 14. The oligomeric compound of any one of embodiments 1-13, wherein the modified oligonucleotide comprises at least one modified internucleoside linkage.

Embodiment 15. The oligomeric compound of embodiment 14, wherein each internucleoside linkage of the modified oligonucleotide is a modified internucleoside linkage.

Embodiment 16. The oligomeric compound of embodiment 14 or 15, wherein the modified internucleoside linkage is a phosphorothioate internucleoside linkage.

Embodiment 17. The oligomeric compound of embodiment 14 or 16, wherein the modified oligonucleotide comprises at least one phosphodiester internucleoside linkage.

Embodiment 18. The oligomer of any one of embodiments 14, 16 and 17, wherein each internucleoside linkage is independently selected from a phosphodiester internucleoside linkage or a phosphorothioate internucleoside linkage. compound.

Embodiment 19. The oligomeric compound of any one of embodiments 1-18, wherein the modified oligonucleotide comprises at least one modified nucleobase.

Embodiment 20 The oligomeric compound of embodiment 19, wherein the modified nucleobase is 5-methyl cytosine.

Embodiment 21. The method according to any one of embodiments 1 to 20, wherein the modified oligonucleotides are 12-30, 12-22, 12-20, 14-20, 15-25, 16-20 , consisting of 18 to 22 or 18 to 20 linked nucleosides.

Embodiment 22. The oligomeric compound according to any one of embodiments 1-21, wherein the modified oligonucleotide consists of 20 linked nucleosides.

Embodiment 23. The modified oligonucleotide of embodiment 22, wherein the modified oligonucleotide has the internucleoside linkage motif soooosssssssssssooss, "s" represents phosphorothioate internucleoside linkage, and "o" is a phosphodiester An oligomeric compound showing an internucleoside linkage.

Embodiment 24 The oligomeric compound according to any one of embodiments 1 to 23, consisting of the modified oligonucleotide.

Embodiment 25 The oligomeric compound of any one of embodiments 1-23, comprising a conjugate group comprising a conjugate moiety and a conjugate linker.

Embodiment 26 The oligomeric compound of embodiment 25, wherein the conjugate group comprises a GalNAc cluster comprising 1 to 3 GalNAc ligands.

Embodiment 27 The oligomeric compound according to embodiment 25 or 26, wherein the conjugate linker consists of a single bond.

Embodiment 28. The oligomeric compound of embodiment 25, wherein the conjugate linker is cleavable.

Embodiment 29. The oligomeric compound of embodiment 28, wherein the conjugate linker comprises 1 to 3 linker-nucleosides.

Embodiment 30 The oligomeric compound according to any one of embodiments 25 to 29, wherein the conjugate group is conjugated to the modified oligonucleotide at the 5′-end of the modified oligonucleotide.

Embodiment 31 The oligomeric compound according to any one of embodiments 25 to 29, wherein the conjugate group is conjugated to the modified oligonucleotide at the 3′-end of the modified oligonucleotide.

Embodiment 32 The oligomeric compound of any one of embodiments 1-31 comprising a terminal group.

Embodiment 33 The oligomeric compound of any one of embodiments 1-32, wherein the oligomeric compound is a single-stranded oligomeric compound.

Embodiment 34 The oligomeric compound of any one of embodiments 1-28 and 30-31, wherein the oligomeric compound does not comprise a linker-nucleoside.

Embodiment 35 The oligomeric compound according to any one of embodiments 1 to 34, wherein the modified oligonucleotide of the oligomeric compound is a salt and the salt is a sodium salt or a potassium salt.

Embodiment 36 An oligomeric duplex comprising the oligomeric compound of any one of embodiments 1-32, 34 and 35.

Embodiment 37. An antisense compound comprising or consisting of the oligomeric compound of any one of embodiments 1-35 or the oligomeric duplex of embodiment 36.

Embodiment 38 A pharmaceutical composition comprising the oligomeric compound of any one of embodiments 1-35 or the oligomeric duplex of embodiment 36 and a pharmaceutically acceptable carrier or diluent.

Embodiment 39. The pharmaceutical composition of embodiment 38, wherein the pharmaceutically acceptable diluent is artificial spinal fluid or PBS.

Embodiment 40 The pharmaceutical composition of embodiment 39, wherein the pharmaceutical composition consists essentially of the modified oligonucleotide and artificial spinal fluid.

Embodiment 41. A method comprising administering to a subject the pharmaceutical composition of any one of embodiments 38-40.

Embodiment 42. A method of treating a neurological condition, comprising administering to an individual having or at risk of developing said neurological condition a therapeutically effective amount of the pharmaceutical composition of any one of Embodiments 38-40; and thereby treating the neurological condition.

Embodiment 43. A method of reducing KCNT1 RNA or KCNT1 protein in the central nervous system of an individual having or at risk of developing a neurological condition, wherein a therapeutically effective amount of the pharmaceutical composition according to any one of embodiments 38 to 40 is administered. to do; and thereby reducing KCNT1 RNA or KCNT1 protein in the central nervous system.

Embodiment 44 The method of embodiment 42 or 43, wherein the neurological condition comprises encephalopathy.

Embodiment 45. The method of embodiment 42 or 43, wherein the neurological condition comprises epilepsy.

Embodiment 46 The method of embodiment 42 or 43, wherein the neurological condition comprises infantile epilepsy.

Embodiment 47 The method of embodiment 46, wherein the infantile epilepsy is childhood epilepsy with migratory focal seizures (EIMFS).

Embodiment 48 The method of embodiment 42 or 43, wherein the neurological condition is autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE).

Embodiment 49. The method of any one of embodiments 42 to 48, wherein said administering is by intrathecal administration.

Embodiment 50 The method of any one of embodiments 42-49, wherein the symptom or characteristic of at least one of the neurological conditions is improved.

Embodiment 51 The method of embodiment 50, wherein the symptom or characteristic is selected from seizures, brain damage, demyelination, muscle weakness, microcephaly, depression, anxiety, cognitive function.

Embodiment 52 The method of any one of embodiments 42-51, wherein the method prevents or slows disease regression.

Embodiment 53. A method of reducing KCNT1 RNA in a cell, comprising: contacting the cell with an oligomeric compound according to any one of embodiments 1 to 35, an oligomeric duplex according to embodiment 36 or an antisense compound according to embodiment 37; and thereby reducing KCNT1 RNA in said cell.

Embodiment 4. A method of reducing KCNT1 protein in a cell, comprising: contacting said cell with an oligomeric compound according to any one of embodiments 1 to 35, an oligomeric duplex according to embodiment 36 or an antisense compound according to embodiment 37; and thereby reducing KCNT1 protein in said cell.

I. Certain oligonucleotides

In certain embodiments, provided herein are oligomeric compounds comprising oligonucleotides consisting of linked nucleosides. The oligonucleotide may be an unmodified oligonucleotide (RNA or DNA), or it may be a modified oligonucleotide. The modified oligonucleotide comprises at least one modification relative to the unmodified RNA or DNA. That is, the modified oligonucleotide comprises at least one modified nucleoside (including modified sugar moieties and/or modified nucleobases) and/or at least one modified internucleoside linkage.

A. Certain modified nucleosides

Modified nucleosides include modified sugar moieties or modified nucleobases or both modified sugar moieties and modified nucleobases.

One. specific sugar moieties

In certain embodiments, the modified sugar moiety is a non-bicyclic modified sugar moiety. In certain embodiments, the modified sugar moiety is a bicyclic or tricyclic sugar moiety. In certain embodiments, the modified sugar moiety is a sugar surrogate. Such sugar substitutes may include one or more substitutions corresponding to other types of modified sugar moieties.

In certain embodiments, the modified sugar moiety is a non-bicyclic modified sugar moiety comprising a furanosyl ring having one or more substituents, with either of these substituents forming a bicyclic structure of two Do not bridge atoms. Such non-bridging substituents may be at any position of the furanosyl, including, but not limited to, substituents at the 2', 4', and/or 5' positions. In certain embodiments, one or more non-bridging substituents of a non-bicyclic modified sugar moiety are branched. Examples of suitable 2'-substituents for non-bicyclic modified sugar moieties are 2'-F, 2'-OCH ₃ ("OMe" or "O-methyl") and 2'-0(CH ₂ ) ₂ OCH ₃ ( "MOE"). In certain embodiments, the 2′-substituent is halo, allyl, amino, azido, SH, CN, OCN, CF ₃ , OCF ₃ , OC ₁ -C ₁₀ alkoxy, OC ₁ -C ₁₀ substituted alkoxy, OC ₁ - C ₁₀ alkyl, OC ₁ -C ₁₀ substituted alkyl, S-alkyl, N(R _m )-alkyl, O-alkenyl, S-alkenyl, N(R _m )-alkenyl, O-alkynyl, S -alkynyl, N(R _m )-alkynyl, O-alkylenyl-O-alkyl, alkynyl, alkaryl, aralkyl, O-alkaryl, O-aralkyl, O(CH ₂ ) ₂ SCH ₃ , O(CH ₂ ) ₂ ON(R _m )(R _n ) or OCH ₂ C(=O)—N(R _m )(R _n ), wherein R _m and R _n are each independently H, amino protecting group or substituted or unsubstituted C ₁ -C ₁₀ alkyl) and US 6,531,584 (Cook et al.); US 5,859,221 (Cook et al.); and 2'-substituents described in US 6,005,087 (Cook et al.). Specific embodiments of these 2'-substituents are from hydroxyl, amino, alkoxy, carboxy, benzyl, phenyl, nitro(NO ₂ ), thiol, thioalkoxy, thioalkyl, halogen, alkyl, aryl, alkenyl and alkynyl. It may be further substituted by one or more independently selected substituents. Examples of suitable 4'-substituents for non-bicyclic modified sugar moieties include, but are not limited to, alkoxy (eg, methoxy), alkyl, and those described in WO 2015/106128 (Manohran et al.). Examples of suitable 5'-substituents for non-bicyclic modified sugar moieties include, but are not limited to, 5-methyl (R or S), 5'-vinyl and 5'-methoxy. In certain embodiments, the non-bicyclic modified sugar moiety comprises more than one non-bridging sugar substituent, e.g., a 2'-F-5'-methyl sugar moiety and WO 2008/101157 (Migawa et al.) and US2013/ 0203836 (Rajeev et al.) and modified sugar moieties and modified nucleosides.

In certain embodiments, the 2′-substituted non-bicyclic modified nucleoside is F, NH ₂ , N ₃ , OCF _{3 ,} OCH ₃ , O(CH ₂ ) ₃ NH ₂ , CH ₂ CH=CH ₂ , OCH ₂ CH=CH ₂ , OCH ₂ CH ₂ OCH ₃ , O(CH ₂ ) ₂ SCH ₃ , O(CH ₂ ) ₂ ON(R _m )(R _n ), O(CH ₂ ) ₂ O(CH ₂ ) ₂ N(CH ₃ ) ₂ and N-substituted acetamides(OCH ₂ C(=O)—N(R _m )(R _n )), wherein R _m and R _n are each independently H, an amino protecting group, or sugar moieties comprising a non-bridging 2′-substituent selected from substituted or unsubstituted C ₁ -C _{10 alkyl.}

In certain embodiments, 2′-substituted nucleosides non-bicyclic modified nucleosides are F, OCF _{3 ,} OCH ₃ , OCH ₂ CH ₂ OCH ₃ , O(CH ₂ ) ₂ SCH ₃ , O(CH _{2 )} ) ₂ ON(CH ₃ ) ₂ , O(CH ₂ ) ₂ O(CH ₂ ) ₂ N(CH ₃ ) ₂ and a _{ratio selected from OCH 2} C(=O)-N(H)CH ₃ (“NMA”) - contains a sugar moiety comprising a bridging 2'-substituent.

In certain embodiments, the 2'-substituted non-bicyclic modified nucleoside comprises a sugar moiety comprising a non-bridging 2'-substituent selected from _{F, OCH 3} and OCH ₂ CH ₂ OCH _{3 .}

Certain modified sugar moieties include substituents that bridge two atoms of the furanosyl ring to form a second ring, resulting in a bicyclic sugar moiety. In certain such embodiments, the bicyclic sugar moiety comprises a bridge between the 4' and 2' furanose ring atoms. Examples of such 4' to 2' bridging sugar substituents are 4'-CH ₂ -2', 4'-(CH ₂ ) ₂ -2', 4'-(CH ₂ ) ₃ -2', 4'-CH ₂ -O-2'("LNA"), 4'-CH ₂ -S-2', 4'-(CH ₂ ) ₂ -O-2'("ENA"), 4'-CH(CH ₃ )- O-2' (referred to as "constrained ethyl" or "cEt"), 4'-CH ₂ -O-CH ₂ -2', 4'-CH ₂ -N(R)-2', 4'- CH(CH ₂ OCH ₃ )-O-2′ (“constrained MOE” or “cMOE”) and analogs thereof (eg, US 7,399,845 (Seth et al.), US 7,569,686 (Bhat et al.), US 7,741,457 (Swayze et al.) ) and US 8,022,193 (Swayze et al.)), 4'-C(CH ₃ )(CH ₃ )-O-2' and analogs thereof (eg US 8,278,283 (Seth et al.)), 4'-CH ₂ -N (OCH ₃ )-2′ and analogs thereof (eg US 8,278,425 (Prakash et al.)), 4′-CH ₂ -ON(CH ₃ )-2′ (eg US 7,696,345 (Allerson et al.) and US Pat. 8,124,745 (Allerson et al.), 4′-CH ₂ —C-(H)(CH ₃ )-2′ (eg, Zhou, et al., J. Org. Chem., 2009, 74, 118 -134), 4'-CH ₂ -C-(=CH ₂ )-2' and analogs thereof (eg US 8,278,426 (Seth et al.)), 4'-C(R _a R _b )-N (R)-O-2', 4'-C(R _a R _b )-ON(R)-2', 4'-CH ₂ -ON(R)-2' and 4'-CH ₂ -N( R)-O-2′, wherein R, R _a and R _b are each independently H, a protecting group or C ₁ -C ₁₂ alkyl (eg, US Pat. No. 7,427,672 to Imanishi et al.), but these is not limited to

In certain embodiments, such 4'-2' bridges are independently -[C(R _a )(R _b )] _n -, -[C(R _a )(R _b )] _n -O-, -C( R _a )=C(R _b )-, -C(R _a )=N-, -C(=NR _a )-, -C(=O)-, -C(=S)-, -O-, -Si(R _a ) ₂ -, -S(=O) _x - and -N(R _a )-, comprising 1 to 4 linked groups independently selected from;

during the meal,

x is 0, 1 or 2;

n is 1, 2, 3 or 4;

R _a and R _b are each independently H, a protecting group, hydroxyl, C ₁ -C ₁₂ alkyl, substituted C ₁ -C ₁₂ alkyl, C ₂ -C ₁₂ alkenyl, substituted C ₂ -C ₁₂ alkenyl, C ₂ -C ₁₂ alkynyl, substituted C ₂ -C ₁₂ alkynyl, C ₅ -C ₂₀ aryl, substituted C ₅ -C ₂₀ aryl, heterocycle radical, substituted heterocycle radical, heteroaryl, substituted hetero aryl, C ₅ -C ₇ alicyclic radical, substituted C ₅ -C ₇ alicyclic radical, halogen, OJ ₁ , NJ ₁ J ₂ , SJ ₁ , N ₃ , COOJ ₁ , acyl(C(=O)-H ), substituted acyl, CN, sulfonyl(S(=O) ₂ -J ₁ ) or sulfoxyl(S(=O)-J ₁ );

J ₁ and J ₂ are each independently H, C ₁ -C ₁₂ alkyl, substituted C ₁ -C ₁₂ alkyl, C ₂ -C ₁₂ alkenyl, substituted C ₂ -C ₁₂ alkenyl, C ₂ -C ₁₂ alkynyl, substituted C ₂ -C ₁₂ alkynyl, C ₅ -C ₂₀ aryl, substituted C ₅ -C ₂₀ aryl, acyl(C(=O)-H), substituted acyl, heterocycle radical, substituted heterocycle radical, C ₁ -C ₁₂ aminoalkyl, substituted C ₁ -C ₁₂ aminoalkyl or a protecting group.

Additional bicyclic sugar moieties are known in the art and are described, for example, in Freier et al., Nucleic Acids Research , 1997, 25 ( 22 ), 4429-4443, Albaek et al., J. Org. Chem ., 2006, 71 , 7731-7740, Singh et al., Chem. Commun. , 1998, 4 , 455-456; Koshkin et al., Tetrahedron , 1998, 54 , 3607-3630; Kumar et al., Bioorg. Med. Chem. Lett ., 1998, 8 , 2219-2222; Singh et al., J. Org. Chem ., 1998, 63 , 10035-10039; Srivastava et al., J. Am. Chem. Soc ., 2007, 129, 8362-8379]; US 7,053,207 (Wengel et al.); US 6,268,490 (Imanishi et al.); US 6,770,748 (Imanishi et al.); US RE44,779 (Imanishi et al.); US 6,794,499 (Wengel et al.); US 6,670,461 (Wengel et al.); US 7,034,133 (Wengel et al.); US 8,080,644 to Wengel et al.; US 8,034,909 to Wengel et al.; US 8,153,365 to Wengel et al.; US 7,572,582 (Wengel et al.); and US 6,525,191 (Ramasamy et al.); WO 2004/106356 (Torsten et al.); WO 1999/014226 (Wengel et al.); WO 2007/134181 (Seth et al.); US 7,547,684 (Seth et al.); US 7,666,854 to Seth et al.; US 8,088,746 (Seth et al.); US 7,750,131 (Seth et al.); US 8,030,467 (Seth et al.); US 8,268,980 (Seth et al.); US 8,546,556 (Seth et al.); US 8,530,640 to Seth et al.; US 9,012,421 (Migawa et al.); US 8,501,805 (Seth et al.); and US Patent Publications US 2008/0039618 (Allerson et al.) and US2015/0191727 (Migawa et al.).

In certain embodiments, bicyclic sugar moieties and nucleosides incorporating such bicyclic sugar moieties are further defined as isomeric configurations. For example, an LNA nucleoside (described herein) may be in the α-L configuration or the β-D configuration.

α-L-methyleneoxy (4'-CH ₂ -O-2') or α-L-LNA bicyclic nucleosides are introduced into oligonucleotides exhibiting antisense activity (Frieden et al., Nucleic Acids Research, 2003, 21 , 6365-6372]). As used herein, a general description of a bicyclic nucleoside includes both isomeric configurations. When the positions of certain bicyclic nucleosides (eg, LNA or cEt) are identified in the embodiments exemplified herein, they are in the β-D configuration, unless otherwise specified.

In certain embodiments, the modified sugar moiety comprises one or more non-bridging sugar substituents and one or more bridging sugar substituents (eg, 5′-substituted and 4′-2′ bridged sugars).

In certain embodiments, the modified sugar moiety is a sugar surrogate. In certain such embodiments, the oxygen atom of the sugar moiety is replaced by, for example, a sulfur, carbon or nitrogen atom. In certain such embodiments, such modified sugar moieties also include bridging and/or non-bridging substituents as described herein. For example, certain sugar substitutes include substitutions at the 4'-sulfur atom and at the 2'-position (see, e.g., US 7,875,733 (Bhat et al.) and US 7,939,677 (Bhat et al.)) and/or at the 5' position. do.

In certain embodiments, sugar substitutes include rings having other than 5 atoms. For example, in certain embodiments, the sugar surrogate comprises a 6 membered tetrahydropyran (“THP”). Such tetrahydropyran may be further modified or substituted. Nucleosides comprising such modified tetrahydropyran include hexitol nucleic acid (“HNA”), anthol nucleic acid (“ANA”), mannitol nucleic acid (“MNA”) (eg, Leumann, CJ. Bioorg & Med. Chem. 2002, 10 , 841-854), fluoro HNA:

(“F-HNA”, e.g., US 8,088,904 (Swayze et al.); US 8,440,803 (Swayze et al.); US 8,796,437 (Swayze et al.); and US 9,005,906 (Swayze et al.); F-HNA is also F-THP or 3 '-Fluoro tetrahydropyran), and nucleosides including additional modified THP compounds having the formula:

(Wherein, independently for each of the above modified THP nucleosides,

Bx is a nucleobase moiety;

T ₃ and T ₄ are each independently an internucleoside linker linking _{the modified THP nucleoside to the remainder of the oligonucleotide, or one of T 3} and T ₄ is the modified THP nucleoside to the remainder of the oligonucleotide. a linking internucleoside linking group, and the other of T ₃ and T ₄ is H, a hydroxyl protecting group, a linked conjugate group, or a 5′ or 3′-terminal group;

q ₁ , q ₂ , q ₃ , q ₄ , q ₅ , q ₆ and q ₇ are each independently H, C ₁ -C ₆ alkyl, substituted C ₁ -C ₆ alkyl, C ₂ -C ₆ alkenyl, substituted C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, or substituted C ₂ -C ₆ alkynyl;

R ₁ and R ₂ are each independently hydrogen, halogen, substituted or unsubstituted alkoxy, NJ ₁ J ₂ , SJ ₁ , N ₃ , OC(=X)J ₁ , OC(=X)NJ ₁ J ₂ , NJ ₃ C(=X)NJ ₁ J ₂ and CN, wherein X is O, S or NJ ₁ and each J ₁ , J ₂ and J ₃ is each independently H or C ₁ -C ₆ alkyl. selected from).

In certain embodiments, modified THP nucleosides are provided wherein _{q 1} , q ₂ , q ₃ , q ₄ , q ₅ , q ₆ and q _{7 are each H.} In certain embodiments, at least one of _{q 1} , q ₂ , q ₃ , q ₄ , q ₅ , q ₆ and q _{7 is other than H.} In certain embodiments, at least one of _{q 1} , q ₂ , q ₃ , q ₄ , q ₅ , q ₆ and q _{7 is methyl.} In certain embodiments, modified THP nucleosides are provided, wherein one of _{R 1} and R _{2 is F.} In certain embodiments, R ₁ is F, R ₂ is H, in certain embodiments, R ₁ is methoxy, R ₂ is H, in certain embodiments, R ₁ is methoxyethoxy, and R ₂ is H.

In certain embodiments, sugar substitutes include rings having more than 5 atoms and more than 1 heteroatom. For example, nucleosides comprising morpholino sugar moieties and their use in oligonucleotides have been reported (e.g., Braasch et al., Biochemistry, 2002, 41 , 4503-4510 and See US 5,698,685 (Summerton et al.); US 5,166,315 (Summerton et al.); US 5,185,444 (Summerton et al.); and US 5,034,506 (Summerton et al.). As used herein, the term "morpholino" refers to a sugar substitute having the structure:

.

.

In certain embodiments, a morpholino may be modified, for example, by adding or altering various substituents from the morpholino structure. Such sugar substitutes are referred to herein as "modified morpholinos."

In certain embodiments, the sugar surrogate comprises an acyclic moiety. Examples of nucleosides and oligonucleotides comprising such acyclic sugar substitutes include peptide nucleic acids (“PNA”), acyclic butyl nucleic acids (eg, Kumar et al., Org. Biomol. Chem. , 2013). , 11 , 5853-5865), and the nucleosides and oligonucleotides described in WO2011/133876 (Manohran et al.).

Many other bicyclic and tricyclic sugars and sugar surrogate ring systems that can be used in modified nucleosides are known in the art.

2. specific modified nucleobases

In certain embodiments, the modified oligonucleotide comprises one or more nucleosides comprising an unmodified nucleobase. In certain embodiments, the modified oligonucleotide comprises one or more nucleosides comprising a modified nucleobase. In certain embodiments, the modified oligonucleotide comprises one or more nucleosides that do not contain a nucleobase, referred to as abasic nucleosides.

In certain embodiments, the modified nucleobases are 5-substituted pyrimidines, 6-azapyrimidines, alkyl or alkynyl substituted pyrimidines, alkyl substituted purines, and N-2, N-6 and O-6 substitutions. selected from purines. In certain embodiments, the modified nucleobase is 2-aminopropyladenine, 5-hydroxymethyl cytosine, xanthine, hypoxanthine, 2-aminoadenine, 6-N-methylguanine, 6-N-methyladenine, 2- Propyladenine, 2-thiouracil, 2-thiothymine and 2-thiocytosine, 5-propynyl (-C≡C-CH ₃ ) uracil, 5-propynylcytosine, 6-azouracil, 6-Azocytosine, 6-Azothymine, 5-ribosyluracil (pseudouracil), 4-thiouracil, 8-halo, 8-amino, 8-thiol, 8-thioalkyl, 8-hydro hydroxyl, 8-aza and other 8-substituted purines, 5-halo, especially 5-bromo, 5-trifluoromethyl, 5-halouracil, and 5-halocytosine, 7-methylguanine, 7- Methyladenine, 2-F-adenine, 2-aminoadenine, 7-deazaguanine, 7-deazaadenine, 3-deazaguanine, 3-deazaadenine, 6-N-benzoyladenine, 2-N-iso Butyrylguanine, 4-N-benzoylcytosine, 4-N-benzoyluracil, 5-methyl 4-N-benzoylcytosine, 5-methyl 4-N-benzoyluracil, universal base, hydrophobic base, promiscuous base , size-extended bases and fluorinated bases. Additional modified nucleobases include tricyclic pyrimidines such as 1,3-diazaphenoxazin-2-one, 1,3-diazaphenothiazin-2-one and 9-(2-aminoethoxy)- 1,3-diazaphenoxazin-2-one (G-clamp). Modified nucleobases also include those in which a purine or pyrimidine base is replaced by another heterocycle, for example 7-deaza-adenine, 7-deazaguanosine, 2-aminopyridine and 2-pyridone. can Additional nucleobases are those disclosed in US 3,687,808 (Merigan et al.), The Concise Encyclopedia Of Polymer Science And Engineering , Kroschwitz, JI, Ed., John Wiley & Sons, 1990, 858-859; Englisch et al. , Angewandte Chemie , International Edition, 1991, 30 , 613; Sanghvi, YS, Chapter 15 , Antisense Research and Applications , Crooke, ST and Lebleu, B., Eds., CRC Press, 1993, 273-288; and in Chapters 6 and 15, Antisense Drug Technology , Crooke ST, Ed., CRC Press, 2008, 163-166 and 442-443.

Publications teaching the preparation of certain above-described modified nucleobases, and other modified nucleobases, include, without limitation, US2003/0158403 (Manohran et al.); US2003/0175906 (Manohran et al.); U.S. 4,845,205 (Dinh et al.); U.S. 5,130,302 (Spielvogel et al.); U.S. 5,134,066 (Rogers et al.); U.S. 5,175,273 (Bischofberger et al.); U.S. 5,367,066 (Urdea et al.); U.S. 5,432,272 (Benner et al.); U.S. 5,434,257 (Matteucci et al.); U.S. 5,457,187 (Gmeiner et al.); U.S. 5,459,255 (Cook et al.); U.S. 5,484,908 (Froehler et al.); U.S. 5,502,177 (Matteucci et al.); U.S. 5,525,711 (Hawkins et al.); U.S. 5,552,540 (Haralambidis et al.); U.S. 5,587,469 (Cook et al.); U.S. 5,594,121 (Froehler et al.); U.S. 5,596,091 (Switzer et al.); U.S. 5,614,617 (Cook et al.); U.S. 5,645,985 (Froehler et al.); U.S. 5,681,941 (Cook et al.); U.S. 5,811,534 (Cook et al.); U.S. 5,750,692 (Cook et al.); U.S. 5,948,903 (Cook et al.); U.S. 5,587,470 (Cook et al.); U.S. 5,457,191 (Cook et al.); U.S. 5,763,588 (Matteucci et al.); U.S. 5,830,653 (Froehler et al.); U.S. 5,808,027 (Cook et al.); 6,166,199 (Cook et al.); and U.S. 6,005,096 (Matteucci et al.).

3. Specific Modified Internucleoside Linkages

In certain embodiments, the nucleosides of the modified oligonucleotides may be linked together using any internucleoside linkage. The two main types of internucleoside linkages are defined by the presence or absence of a phosphorus atom. Representative phosphorus containing internucleoside linkages include phosphodiester bonds (“P=O”) (also referred to as unmodified or naturally occurring linkages), phosphotriesters, methylphosphonates, phosphoramidates, and phosphoros. phosphates containing thioates (“P=S”) and phosphorodithioates (“HS-P=S”). Representative non-phosphorus internucleoside linkages include methylenemethylimino (-CH ₂ -N(CH ₃ )-O-CH ₂ -), thiodiester, thionocarbamate (-OC(=O)(NH) -S-); siloxane (-O-SiH ₂ -O-); and N,N′-dimethylhydrazine (—CH ₂ —N(CH ₃ )—N(CH ₃ )—). Compared to naturally occurring phosphate linkages, modified internucleoside linkages can be used to alter, typically increase, the nuclease resistance of an oligonucleotide. In certain embodiments, internucleoside linkages having a chiral carbon can be prepared as a racemic mixture or as separate enantiomers. Methods for the preparation of phosphorus-containing and phosphorus-free internucleoside linkages are well known to those skilled in the art.

Representative internucleoside linkages having a chiral center include, but are not limited to, alkylphosphonates and phosphorothioates. A modified oligonucleotide comprising an internucleoside linkage having a chiral center is a population of modified oligonucleotides comprising a stereorandom internucleoside linkage in a particular stereochemical configuration or a modification comprising a phosphorothioate linkage. It can be prepared as a population of oligonucleotides. In certain embodiments, the population of modified oligonucleotides comprises phosphorothioate internucleoside linkages wherein all phosphorothioate internucleoside linkages are stereorandom. Such modified oligonucleotides can be generated using synthetic methods that result in random selection of the stereochemical configuration of each phosphorothioate linkage. Nevertheless, each individual phosphorothioate of each individual oligonucleotide molecule has a defined conformation, as will be well understood by one of ordinary skill in the art. In certain embodiments, the population of modified oligonucleotides is enriched for modified oligonucleotides comprising one or more specific phosphorothioate internucleoside linkages in certain independently selected stereochemical configurations. In certain embodiments, a particular configuration of a particular phosphorothioate linkage is present in at least 65% of the molecules in the population. In certain embodiments, a particular configuration of a particular phosphorothioate linkage is present in at least 70% of the molecules in the population. In certain embodiments, a particular configuration of a particular phosphorothioate linkage is present in at least 80% of the molecules in the population. In certain embodiments, a particular configuration of a particular phosphorothioate linkage is present in at least 90% of the molecules in the population. In certain embodiments, a particular configuration of a particular phosphorothioate linkage is present in at least 99% of the molecules in the population. Such chirally rich populations of modified oligonucleotides can be prepared by synthetic methods known in the art, eg, described in Oka et al., JACS 125, 8307 (2003), Wan et al. Nuc. Acid. Res . 42, 13456 (2014)] and WO 2017/015555. In certain embodiments, the population of oligonucleotides is a modified nucleotide (S p) the nucleotide is rich in a modified oligonucleotide having at least one of the indicated phosphorothioate of coordination. In certain embodiments, the population of modified oligonucleotides is enriched for modified oligonucleotides having at least one phosphorothioate in the ( R p ) configuration. In certain embodiments, (R p) and / or (S p) to oligonucleotides modified nucleotides each containing a phosphorothioate formula include one or more of (here, "B" denotes a nucleobase):

.

.

Unless otherwise indicated, the chiral internucleoside linkages of the modified oligonucleotides described herein may exist in stereorandom or in certain stereochemical configurations.

Neutral internucleoside linkages include, without limitation, phosphotriesters, methylphosphonates, MMI(3'-CH ₂ -N(CH ₃ )-O-5'), amide-3(3'-CH ₂ - C(=O)-N(H)-5'), amide-4(3'-CH ₂ -N(H)-C(=O)-5'), formacetal (3'-O-CH ₂ -O-5'), methoxypropyl and thioformacetal (3'-S-CH ₂ -O-5'). Additional neutral internucleoside linkages include nonionic linkages including siloxanes (dialkylsiloxanes), carboxylate esters, carboxamides, sulfides, sulfonate esters and amides (see, e.g., Carbohydrate Modifications in Antisense Research ; YS Sanghvi and PD Cook, Eds., ACS Symposium Series 580; Chapters 3 and 4, 40-65). Additional neutral internucleoside linkages include nonionic linkages comprising mixed N, O, S and CH _{2 component moieties.}

B. specific motif

In certain embodiments, the modified oligonucleotide comprises one or more modified nucleosides comprising a modified sugar moiety. In certain embodiments, the modified oligonucleotide comprises one or more modified nucleosides comprising a modified nucleobase. In certain embodiments, the modified oligonucleotide comprises one or more modified internucleoside linkages. In such embodiments, the modified, unmodified, and otherwise modified sugar moieties, nucleobases, and/or internucleoside linkages of the modified oligonucleotide define a pattern or motif. In certain embodiments, the patterns of sugar moieties, nucleobases, and internucleoside linkages are each independent of each other. Thus, a modified oligonucleotide may be described by its sugar motif, nucleobase motif, and/or internucleoside linkage motif (as used herein, a nucleobase motif is a nucleobase independent of the sequence of the nucleobase). modifications to the base are described).

One. specific party motifs

In certain embodiments, the oligonucleotide comprises one or more types of modified sugars and/or unmodified sugar moieties arranged along the oligonucleotide or region thereof in a defined pattern or sugar motif. In certain instances, such sugar motifs include, but are not limited to, any of the sugar modifications described herein.

In certain embodiments, the modified oligonucleotide comprises and consists of a region having a gapmer motif defined by two outer regions or “wings” and a central or internal region or “gap”. The three regions of the gapmer motif (5'-wing, gap and 3'-wing) form a contiguous sequence of nucleosides, wherein at least some of the sugar moieties of the nucleosides of each wing are nucleosides of the gap different from at least some of the sugar moieties of the side. Specifically, at least the sugar moiety of the nucleoside of each wing closest to the gap (the 3'-nearest nucleoside of the 5'-wing and the 5'-nearest nucleoside of the 3'-wing) is a neighbor differs from the sugar moiety of the gap nucleoside, defining the boundary between the wing and the gap (ie, the wing/gap junction). In certain embodiments, the sugar moieties in the gap are identical to each other. In certain embodiments, the gap comprises one or more nucleosides having a sugar moiety different from that of one or more other nucleosides of the gap. In certain embodiments, the sugar motifs of the two wings are identical to each other (symmetric gapmers). In certain embodiments, the sugar motif of the 5'-wing is different from the sugar motif of the 3'-wing (asymmetric gapmer).

In certain embodiments, the wings of a gapmer comprise 1 to 5 nucleosides. In certain embodiments, each nucleoside of each wing of the gapmer is a modified nucleoside. In certain embodiments, at least one nucleoside of each wing of the gapmer is a modified nucleoside. In certain embodiments, at least two nucleosides of each wing of the gapmer are modified nucleosides. In certain embodiments, at least three nucleosides of each wing of the gapmer are modified nucleosides. In certain embodiments, at least four nucleosides of each wing of the gapmer are modified nucleosides.

In certain embodiments, the gap of the gapmer comprises 7 to 12 nucleosides. In certain embodiments, each nucleoside of the gap of the gapmer is an unmodified 2'-deoxynucleoside. In certain embodiments, at least one nucleoside in the gap of the gapmer is a modified nucleoside.

In certain embodiments, the gapmer is a deoxy gapmer. In certain embodiments, the nucleoside on the gap side of each wing/gap junction is an unmodified 2'-deoxynucleoside and the nucleoside on the wing side of each wing/gap junction is a modified nucleoside . In certain embodiments, each nucleoside of the gap is an unmodified 2'-deoxynucleoside. In certain embodiments, each nucleoside of each wing of the gapmer is a modified nucleoside.

In certain embodiments, the modified oligonucleotide comprises or consists of a region having a fully modified sugar motif. In such embodiments, each nucleoside of the fully modified region of the modified oligonucleotide comprises a modified sugar moiety. In certain embodiments, each nucleoside of the entire modified oligonucleotide comprises a modified sugar moiety. In certain embodiments, the modified oligonucleotide comprises or consists of a region having a fully modified sugar motif, wherein each nucleoside within the fully modified region is the same, referred to herein as a uniformly modified sugar motif. modified sugar moieties. In certain embodiments, the fully modified oligonucleotide is a uniformly modified oligonucleotide. In certain embodiments, each nucleoside of the uniformly modified comprises the same 2'-modification.

Here, the length (number of nucleosides) of the three regions of the gapmer can be given using the notation: [number of nucleosides in the 5'-wing] - [number of nucleosides in the gap] - [Number of nucleosides in the 3'-wing]. Thus, a 5-10-5 gapmer consists of 5 linked nucleosides in each wing and 10 linked nucleosides in the gap. This nomenclature, when preceded by a particular modification, is a modification at each sugar moiety of each wing, and the gap nucleoside includes an unmodified deoxynucleoside sugar. Thus, a 5-10-5 MOE gapmer consists of 5 linked MOE modified nucleosides in the 5'-wing, 10 linked deoxynucleosides in the gap and 5 linked MOE nucleosides in the 3'-wing. .

In certain embodiments, the modified oligonucleotide is a 5-10-5 MOE gapmer. In certain embodiments, the modified oligonucleotide is a 3-10-3 BNA gapmer. In certain embodiments, the modified oligonucleotide is a 3-10-3 cEt gapmer. In certain embodiments, the modified oligonucleotide is a 3-10-3 LNA gapmer.

2. specific nucleobase motif

In certain embodiments, the oligonucleotide comprises modified and/or unmodified nucleobases arranged along the oligonucleotide or region thereof in a defined pattern or motif. In certain embodiments, each nucleobase is modified. In certain embodiments, none of the nucleobases are modified. In certain embodiments, each purine or each pyrimidine is modified. In certain embodiments, each adenine is modified. In certain embodiments, each guanine is modified. In certain embodiments, each thymine is modified. In certain embodiments, each uracil is modified. In certain embodiments, each cytosine is modified. In certain embodiments, some or all of the cytosine nucleobases in the modified oligonucleotide are 5-methyl cytosine. In certain embodiments, all of the cytosine nucleobases are 5-methyl cytosine and all of the other nucleobases of the modified oligonucleotide are unmodified nucleobases.

In certain embodiments, the modified oligonucleotide comprises a block of modified nucleobases. In this particular embodiment, the block is at the 3'-end of the oligonucleotide. In certain embodiments, the block is within three nucleosides of the 3'-end of the oligonucleotide. In certain embodiments, the block is at the 5'-end of the oligonucleotide. In certain embodiments, the block is within three nucleosides of the 5'-end of the oligonucleotide.

In certain embodiments, an oligonucleotide comprising a gapmer motif comprises a nucleoside comprising a modified nucleobase. In this particular embodiment, one nucleoside comprising a modified nucleobase is present in the central gap of the oligonucleotide having a gapmer motif. In certain such embodiments, the sugar moiety of the nucleoside is a 2'-deoxyribosyl moiety. In certain embodiments, the modified nucleobase is selected from 2-thiopyrimidine and 5-propynepyrimidine.

3. Specific internucleoside linkage motifs

In certain embodiments, the oligonucleotide comprises modified and/or unmodified internucleoside linkages arranged along the oligonucleotide or region thereof in a defined pattern or motif. In certain embodiments, each internucleoside linkage is a phosphodiester internucleoside linkage (P=O). In certain embodiments, each internucleoside linkage of the modified oligonucleotide is a phosphorothioate internucleoside linkage (P=S). In certain embodiments, each internucleoside linkage of the modified oligonucleotide is independently selected from a phosphorothioate internucleoside linkage and a phosphodiester internucleoside linkage. In certain embodiments, each phosphorothioate internucleoside linkage is independently selected from a stereorandom phosphorothioate, (S p) phosphorothioate, and ( R p) phosphorothioate. In certain embodiments, the sugar motif of the modified oligonucleotide is a gapmer, and all internucleoside linkages within the gap are modified. In certain such embodiments, some or all of the internucleoside linkage in the wing is an unmodified phosphodiester internucleoside linkage. In certain embodiments, the terminal internucleoside linkage is modified. In certain embodiments, the sugar motif of the modified oligonucleotide is a gapmer, the internucleoside linkage motif comprises at least one phosphodiester internucleoside linkage in at least one wing, and at least one phosphodiester internucleoside linkage The ester linkage is not a terminal internucleoside linkage, and the remaining internucleoside linkage is a phosphorothioate internucleoside linkage. In this particular embodiment, all of the phosphorothioate linkages are stereorandom. In certain embodiments, all of the force thio captivity Eight connections on the wing are phosphorothioate Eight thio (S p), the gap comprises at least one S p, S p, R p motifs. In certain embodiments, the population of modified oligonucleotides is enriched for modified oligonucleotides comprising such internucleoside linkage motifs.

C. specific length

It is possible to increase or decrease the length of an oligonucleotide without eliminating activity. For example, in Woolf et al. (Proc. Natl. Acad. Sci. USA 89:7305-7309, 1992), a series of oligonucleotides 13 to 25 nucleobases in length is cleaved of target RNA in an oocyte injection model. was tested for its ability to induce Oligonucleotides 25 nucleobases in length with 8 or 11 mismatch bases near the end of the oligonucleotide can direct specific cleavage of the target RNA to a lesser extent than oligonucleotides containing no mismatches. Similarly, target specific cleavage was achieved using 13 nucleobase oligonucleotides, eg those with 1 or 3 mismatches.

In certain embodiments, oligonucleotides (including modified oligonucleotides) may have any of a variety of ranges in length. In certain embodiments, the oligonucleotide consists of X to Y linked nucleosides, wherein X represents the smallest number of nucleosides in the range and Y represents the largest number of nucleosides in the range. . In certain such embodiments, X and Y are each independently 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26 , 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 and 50 become; provided that X≤Y. For example, in certain embodiments, the oligonucleotides are 12 to 13, 12 to 14, 12 to 15, 12 to 16, 12 to 17, 12 to 18, 12 to 19, 12 to 20, 12 to 21, 12 to 22, 12 to 23, 12 to 24, 12 to 25, 12 to 26, 12 to 27, 12 to 28, 12 to 29, 12 to 30, 13 to 14, 13 to 15, 13 to 16, 13 to 17, 13 to 18, 13 to 19, 13 to 20, 13 to 21, 13 to 22, 13 to 23, 13 to 24, 13 to 25, 13 to 26, 13 to 27, 13 to 28, 13 to 29, 13 to 30, 14 to 15, 14 to 16, 14 to 17, 14 to 18, 14 to 19, 14 to 20, 14 to 21, 14 to 22, 14 to 23, 14 to 24, 14 to 25, 14 to 26, 14 to 27, 14 to 28, 14 to 29, 14 to 30, 15 to 16, 15 to 17, 15 to 18, 15 to 19, 15 to 20, 15 to 21, 15 to 22, 15 to 23, 15 to 24, 15 to 25, 15 to 26, 15 to 27, 15 to 28, 15 to 29, 15 to 30, 16 to 17, 16 to 18, 16 to 19, 16 to 20, 16 to 21, 16 to 22, 16 to 23, 16 to 24, 16 to 25, 16 to 26, 16 to 27, 16 to 28, 16 to 29, 16 to 30, 17 to 18, 17 to 19, 17 to 20, 17 to 21, 17 to 22, 17 to 23, 17 to 24, 17 to 25, 17 to 26, 17 to 27, 17 to 28, 17 to 29, 17 to 30, 18 to 19, 18 to 20, 18 to 21, 18 to 22,18 to 23, 18 to 24, 18 to 25, 18 to 26, 18 to 27, 18 to 28, 18 to 29, 18 to 30, 19 to 20, 19 to 21, 19 to 22, 19 to 23, 19 to 24, 19-25, 19-26, 19-29, 19-28, 19-29, 19-30, 20-21, 20-22, 20-23, 20-24, 20-25, 20-26, 20 to 27, 20 to 28, 20 to 29, 20 to 30, 21 to 22, 21 to 23, 21 to 24, 21 to 25, 21 to 26, 21 to 27, 21 to 28, 21 to 29, 21 to 30, 22 to 23, 22 to 24, 22 to 25, 22 to 26, 22 to 27, 22 to 28, 22 to 29, 22 to 30, 23 to 24, 23 to 25, 23 to 26, 23 to 27, 23-28, 23-29, 23-30, 24-25, 24-26, 24-27, 24-28, 24-29, 24-30, 25-26, 25-27, 25-28, 25-27 29, 25-30, 26-27, 26-28, 26-29, 26-30, 27-28, 27-29, 27-30, 28-29, 28-30, or 29-30 linked nucleos made by the side

D. Certain modified oligonucleotides

In certain embodiments, the modifications (sugars, nucleobases, internucleoside linkages) are introduced into the modified oligonucleotide. In certain embodiments, the modified oligonucleotide is characterized by its modification motif and overall length. In certain embodiments, each of these parameters is independent of each other. Thus, unless otherwise indicated, each internucleoside linkage of an oligonucleotide having a gapmer sugar motif may be modified or unmodified, and may or may not follow the gapmer modification pattern of sugar modifications. For example, the internucleoside linkage in the wing region of the sugar gapmer may be the same or different from each other, and may be the same or different from the internucleoside linkage in the gap region of the sugar motif. Likewise, such sugar gapmer oligonucleotides may comprise one or more modified nucleobases independent of the gapmer pattern of sugar modifications. Unless otherwise indicated, all modifications are independent of nucleobase sequence.

E. specific population of modified oligonucleotides

The population of modified oligonucleotides in which all of the modified oligonucleotides of the population have the same molecular formula may be a stereorandom population or a chirally enriched population. All chiral centers of all modified oligonucleotides are stereorandom in the stereorandom population. In a chiral rich population, at least one particular chiral center is not stereorandom in the modified oligonucleotides of the population. In certain embodiments, the chirally enriched population of modified oligonucleotides is enriched in β-D ribosyl sugar moieties and all phosphorothioate internucleoside linkages are stereorandom. In certain embodiments, the chirally enriched population of modified oligonucleotides is enriched in both a β-D ribosyl sugar moiety and at least one, a particular phosphorothioate internucleoside linkage, in a particular stereochemical configuration.

F. nucleobase sequence

In certain embodiments, the oligonucleotide (unmodified or modified oligonucleotide) is further described by its nucleobase sequence. In certain embodiments the oligonucleotide has a nucleobase sequence that is complementary to a second oligonucleotide or to an identified reference nucleic acid, such as a target nucleic acid. In certain such embodiments, the region of the oligonucleotide has a nucleobase sequence complementary to the second oligonucleotide or to an identified reference nucleic acid, eg, a target nucleic acid. In certain embodiments, a region or full length nucleobase sequence of an oligonucleotide is at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least from a second oligonucleotide or nucleic acid, e.g., a target nucleic acid. 90%, at least 95% or 100% complementarity.

I. Certain oligomeric compounds

In certain embodiments, provided herein are oligomeric compounds consisting of an oligonucleotide (modified or unmodified) and optionally one or more conjugate groups and/or end groups. A conjugate group consists of one or more conjugate moieties and a conjugate linker that connects the conjugate moiety to the oligonucleotide. The conjugate groups may be attached to either or both ends of the oligonucleotide and/or at any internal location. In certain embodiments, the conjugate group is attached at the 2'-position of the nucleoside of the modified oligonucleotide. In certain embodiments, the conjugate groups attached to either or both ends of the oligonucleotide are terminal groups. In certain such embodiments, the conjugate group or end group is attached at the 3' and/or 5'-end of the oligonucleotide. In certain such embodiments, the conjugate group (or end group) is attached at the 3′-end of the oligonucleotide. In certain embodiments, the conjugate group is attached near the 3'-end of the oligonucleotide. In certain embodiments, the conjugate group (or terminal group) is attached at the 5′-end of the oligonucleotide. In certain embodiments, the conjugate group is attached near the 5'-end of the oligonucleotide.

Examples of end groups include, but are not limited to, conjugate groups, capping groups, phosphate moieties, protecting groups, modified or unmodified nucleosides, and independently modified or unmodified two or more nucleosides. does not

A. specific conjugate groups

In certain embodiments, the oligonucleotide is covalently attached to one or more conjugate groups. In certain embodiments, the conjugate group alters one or more properties of the attached oligonucleotide, including, but not limited to, pharmacodynamics, pharmacokinetics, stability, binding, uptake, tissue distribution, cellular distribution, cellular uptake, charge and clearance. . In certain embodiments, the conjugate group confers a novel property to an attached oligonucleotide, eg, a fluorophore or reporter group that allows attachment of the oligonucleotide. Certain conjugate groups and conjugate moieties, such as cholesterol moieties (Letsinger et al., Proc. Natl. Acad. Sci. USA, 1989, 86, 6553-6556), cholic acid (Manohran et al. , Bioorg. Med. Chem. Lett ., 1994, 4 , 1053-1060), thioethers such as hexyl-S-tritylthiol (Manoharan et al., Ann. NY Acad. Sci . , 1992, 660 , 306-309; Manoharan et al., Bioorg. Med. Chem. Lett., 1993, 3 , 2765-2770), thiocholesterol (Oberhauser et al., Nucl. Acids Res ., 1992 , 20 , 533-538), aliphatic chains such as dodecane-diol or undecyl residues (Saison-Behmoaras et al., EMBO J., 1991, 10 , 1111-1118; Kabanov et al. , FEBS Lett ., 1990, 259 , 327-330; Svinarchuk et al., Biochimie , 1993, 75 , 49-54), phospholipids such as di-hexadecyl-rac-glycerol or triethyl-ammonium 1 ,2-Di-O-hexadecyl-rac-glycero-3-H-phosphonate ( Manohran et al., Tetrahedron Lett ., 1995, 36 , 3651-3654; Shea et al., Nucl. Acids) Res ., 1990, 18 , 3777-3783), polyamine or polyethylene glycol chains (Manoharan et al., Nucleosides & Nucleotides , 1995, 14 , 969-973), or adamantane acetate palmityl moieties ( Mishra et al., Biochim. Biophys. Acta , 1995, 1264, 229-237), octadecylamine or hexylamino-carbonyl-oxycholester roll moieties (Crooke et al., J. Pharmacol. Exp. Ther., 1996, 277 , 923-937), tocopherol groups (Nishina et al., Molecular Therapy nucleic acids , 2015 , 4 , e220; and Nishina et al., Molecular Therapy, 2008, 16 , 734-740 ]), or GalNAc clusters (eg WO2014/179620) have already been described.

One. conjugate moiety

Conjugate moieties include, without limitation, intercalators, reporter molecules, polyamines, polyamides, peptides, carbohydrates, vitamin moieties, polyethylene glycols, thioethers, polyethers, cholesterol, thiocholesterol, cholic acid moieties. , folate, lipid, phospholipid, biotin, phenazine, phenanthridine, anthraquinone, adamantane, acridine, fluorescein, rhodamine, coumarin, fluorophores and dyes.

In certain embodiments, the conjugate moiety is an active drug substance such as aspirin, warfarin, phenylbutazone, ibuprofen, suprofen, fen-bufen, ketoprofen, ( S )-(+)-pranoprofen, Carprofen, dancilsarcosine, 2,3,5-triiodobenzoic acid, fingolimod, flufenamic acid, folinic acid, benzothiadiazide, chlorothiazide, diazepine, indo-methicin, barbiturate , cephalosporins, sulfa drugs, antidiabetic agents, antibacterial agents or antibiotics.

2. conjugate linker

The conjugate moiety is attached to the oligonucleotide via a conjugate linker. In certain oligomeric compounds, the conjugate linker is a single chemical bond (ie, the conjugate moiety is attached directly to the oligonucleotide through the single bond). In certain embodiments, the conjugate linker comprises an oligomer of chain structures, such as hydrocarbyl chains, or repeat units, such as ethylene glycol, nucleosides, or amino acid units.

In certain embodiments, the conjugate linker comprises one or more groups selected from alkyl, amino, oxo, amide, disulfide, polyethylene glycol, ether, thioether and hydroxylamino. In certain such embodiments, the conjugate linker comprises a group selected from alkyl, amino, oxo, amide and ether groups. In certain embodiments, the conjugate linker comprises a group selected from alkyl and amide groups. In certain embodiments, the conjugate linker comprises a group selected from alkyl and ether groups. In certain embodiments, the conjugate linker comprises at least one phosphorous moiety. In certain embodiments, the conjugate linker comprises at least one phosphate group. In certain embodiments, the conjugate linker comprises at least one neutral linking group.

In certain embodiments, conjugate linkers, including those described above, are bifunctional linking moieties, such as those known in the art to be useful for attaching a conjugate group to a parent compound, such as an oligonucleotide provided herein. am. Generally, the bifunctional linking moiety comprises at least two functional groups. One of the functional groups is selected to bind to a specific site in the parent compound and the other is selected to bind to the conjugate group. Examples of functional groups used in bifunctional linking moieties include, but are not limited to, electrophiles for reacting with nucleophilic groups and nucleophiles for reacting with electrophilic groups. In certain embodiments, the bifunctional linking moiety comprises one or more groups selected from amino, hydroxyl, carboxylic acid, thiol, alkyl, alkenyl and alkynyl.

Examples of conjugate linkers are pyrrolidine, 8-amino-3,6-dioxaoctanoic acid (ADO), succinimidyl 4-(N-maleimidomethyl) cyclo-hexane-1-carboxylate (SMCC) and 6- aminohexanoic acid (AHEX or AHA). Other conjugate linkers include substituted or unsubstituted C ₁ -C ₁₀ alkyl, substituted or unsubstituted C ₂ -C ₁₀ alkenyl or substituted or unsubstituted C ₂ -C ₁₀ alkynyl, wherein the A non-limiting list includes, but is not limited to, hydroxyl, amino, alkoxy, carboxy, benzyl, phenyl, nitro, thiol, thioalkoxy, halogen, alkyl, aryl, alkenyl and alkynyl). .

In certain embodiments, the conjugate linker comprises 1 to 10 linker-nucleosides. In certain embodiments, the conjugate linker comprises 2 to 5 linker-nucleosides. In certain embodiments, the conjugate linker comprises exactly three linker-nucleosides. In certain embodiments, the conjugate linker comprises a TCA motif. In certain embodiments, such linker-nucleosides are modified nucleosides. In certain embodiments such linker-nucleosides comprise modified sugar moieties. In certain embodiments, the linker-nucleoside is unmodified. In certain embodiments, the linker-nucleoside comprises an optionally protected heterocyclic base selected from a purine, a substituted purine, a pyrimidine or a substituted pyrimidine. In certain embodiments, the cleavable moiety is uracil, thymine, cytosine, 4-N-benzoylcytosine, 5-methyl cytosine, 4-N-benzoyl-5-methyl cytosine, adenine, 6-N - a nucleoside selected from benzoyladenine, guanine and 2-N-isobutyrylguanine. Typically, it is preferred that the linker-nucleoside be cleaved from the oligomeric compound after it reaches the target tissue. Thus, linker-nucleosides are typically linked to each other and to the remainder of the oligomeric compound through cleavable bonds. In certain embodiments, such a cleavable bond is a phosphodiester bond.

Here, the linker-nucleoside is not considered to be part of the oligonucleotide. Accordingly, the oligomeric compound comprises an oligonucleotide consisting of a stated number or range of linked nucleosides and/or a stated percentage complementarity to a reference nucleic acid, wherein the oligomeric compound also comprises a linker-nucleoside. In embodiments comprising a group, such linker-nucleosides are not counted towards the length of the oligonucleotide and are not used to determine the percent complementarity of the oligonucleotide to a reference nucleic acid. For example, the oligomeric compound comprises (1) a modified oligonucleotide consisting of 8 to 30 nucleosides and (2) 1 to 10 linker-nucleosides adjacent to the nucleosides of the modified oligonucleotide. may contain conjugate groups. The total number of contiguously linked nucleosides in these oligomeric compounds is greater than 30. Alternatively, the oligomeric compound may comprise a modified oligonucleotide consisting of 8 to 30 nucleosides without a conjugate group. The total number of contiguously linked nucleosides in these oligomeric compounds is less than 30. Unless otherwise indicated, a conjugate linker contains no more than 10 linker-nucleosides. In certain embodiments, the conjugate linker comprises no more than 5 linker-nucleosides. In certain embodiments, the conjugate linker comprises no more than three linker-nucleosides. In certain embodiments, the conjugate linker comprises no more than two linker-nucleosides. In certain embodiments, the conjugate linker comprises no more than one linker-nucleoside.

In certain embodiments, it is preferred for the conjugate group to be cleaved from the oligonucleotide. For example, in certain circumstances, an oligomeric compound comprising a particular conjugate moiety is better taken up by a particular cell type, but once the oligomeric compound is taken up, it may be difficult for the cleaved conjugate group to release the unconjugated or parent oligonucleotide. desirable. Accordingly, certain conjugate linkers may include one or more cleavable moieties. In certain embodiments, the cleavable moiety is a cleavable bond. In certain embodiments, a cleavable moiety is a group of atoms comprising at least one cleavable bond. In certain embodiments, the cleavable moiety comprises a group of atoms having 1, 2, 3, 4, or more than 4 cleavable bonds. In certain embodiments, the cleavable moiety is selectively cleaved within a cell or subcellular compartment, such as a lysosome. In certain embodiments, the cleavable moiety is selectively cleaved by an endogenous enzyme, such as a nuclease.

In certain embodiments, the cleavable bond is selected from one or both of an amide, an ester, an ether, an ester of a phosphodiester, a phosphate ester, a carbamate or a disulfide. In certain embodiments, the cleavable bond is one or both of the esters of a phosphodiester. In certain embodiments, the cleavable moiety comprises a phosphate or phosphodiester. In certain embodiments, the cleavable moiety is a phosphate linkage between the oligonucleotide and the conjugate moiety or conjugate group.

In certain embodiments, the cleavable moiety comprises or consists of one or more linker-nucleosides. In certain such embodiments, the one or more linker-nucleosides are linked to each other and/or to the remainder of the oligomeric compound via a cleavable bond. In certain embodiments, such cleavable linkages are unmodified phosphodiester linkages. In certain embodiments, the cleavable moiety is attached to the 3' or 5'-terminal nucleoside of the oligonucleotide by a phosphate internucleoside linkage and a conjugate linker or conjugate moiety by a phosphate or phosphorothioate linkage. is a 2'-deoxy nucleoside covalently attached to the remainder of In certain such embodiments, the cleavable moiety is 2'-deoxyadenosine.

B. specific end groups

In certain embodiments, the oligomeric compound comprises one or more end groups. In certain such embodiments, the oligomeric compound comprises a stabilized 5'-phosphate. Stabilized 5'-phosphates include, but are not limited to, 5'-phosphonates such as, but not limited to, 5'-vinylphosphonates. In certain embodiments, the terminal group comprises one or more abasic nucleosides and/or inverted nucleosides. In certain embodiments, the terminal group comprises one or more 2'-linked nucleosides. In certain such embodiments, the 2'-linked nucleoside is an abasic nucleoside.

III. oligomeric duplex

In certain embodiments, the oligomeric compounds described herein comprise oligonucleotides having a nucleobase sequence that is complementary to that of a target nucleic acid. In certain embodiments, the oligomeric compound is paired with a second oligomeric compound to form an oligomeric duplex. Such oligomeric duplexes include a first oligomeric compound having a region complementary to a target nucleic acid and a second oligomeric compound having a region complementary to the first oligomeric compound. In certain embodiments, the first oligomeric compound of the oligomeric duplex comprises or comprises (1) a modified or unmodified oligonucleotide and optionally a conjugate group and (2) a second modified or unmodified oligonucleotide and optionally a conjugate group. is made of Either or both of the oligomeric compounds of the oligomeric duplex may comprise conjugate groups. The oligonucleotides of each oligomeric compound of the oligomeric duplex may include non-complementary overhanging nucleosides.

IV. antisense activity

In certain embodiments, the oligomeric compound and the oligomeric duplex are capable of hybridizing to a target nucleic acid, resulting in at least one antisense activity; These oligomeric compounds and oligomeric duplexes are antisense compounds. In certain embodiments, the antisense compound has antisense activity when it reduces or inhibits the amount or activity of a target nucleic acid by at least 25% in a standard cellular assay. In certain embodiments, the antisense compound selectively affects one or more target nucleic acids. Such antisense compounds hybridize to one or more target nucleic acids and thereby produce one or more desired antisense activity, do not hybridize to one or more non-target nucleic acids, or hybridize to one or more non-target nucleic acids in a manner that results in significant undesired antisense activity. Contains non-nucleobase sequences.

In certain antisense activities, hybridization of an antisense compound to a target nucleic acid results in recruitment of a protein that cleaves the target nucleic acid. For example, certain antisense compounds cause RNase H mediated cleavage of a target nucleic acid. RNase H is a cellular endonuclease that cleaves the RNA strand of an RNA:DNA duplex. The DNA in this RNA:DNA duplex need not be unmodified DNA. In certain embodiments, described herein are antisense compounds that are sufficiently "DNA-like" to elicit RNase H activity. In certain embodiments, one or more non-DNA-like nucleosides in the gap of the gapmer are tolerated.

In certain antisense activities, the antisense compound or a portion of the antisense compound is loaded into an RNA-induced silencing complex (RISC), ultimately cleaving the target nucleic acid. For example, certain antisense compounds result in cleavage of a target nucleic acid by Argonaute. Antisense compounds loaded with RISC are RNAi compounds. RNAi compounds may be double-stranded (siRNA) or single-stranded (ssRNA).

In certain embodiments, hybridization of an antisense compound to a target nucleic acid does not result in recruitment of a protein that cleaves the target nucleic acid. In certain embodiments, hybridization of an antisense compound to a target nucleic acid results in an alteration of splicing of the target nucleic acid. In certain embodiments, hybridization of an antisense compound to a target nucleic acid results in inhibition of a binding interaction between the target nucleic acid and a protein or other nucleic acid. In certain embodiments, hybridization of an antisense compound to a target nucleic acid results in altered translation of the target nucleic acid.

Antisense activity can be observed directly or indirectly. In certain embodiments, the observation or detection of antisense activity results in a change in the amount of a target nucleic acid or protein encoded by such target nucleic acid, a change in the proportion of splice variants of the nucleic acid or protein, and/or a change in the phenotype in a cell or subject. It involves observation or detection.

V. specific target nucleic acid

In certain embodiments, the oligomeric compound comprises or consists of an oligonucleotide comprising a region complementary to a target nucleic acid. In certain embodiments, the target nucleic acid is an endogenous RNA molecule. In certain embodiments, the target nucleic acid encodes a protein. In certain such embodiments, the target nucleic acid is selected from mature mRNA and pre-mRNA, eg, introns, exons and untranslated regions. In certain embodiments, the target RNA is a mature mRNA. In certain embodiments, the target nucleic acid is a pre-mRNA. In this particular embodiment, the target region is all within an intron. In certain embodiments, the target region spans an intron/exon junction. In certain embodiments, the target region is at least 50% within the intron. In certain embodiments, the target nucleic acid is an RNA transcription product of a retrogene. In certain embodiments, the target nucleic acid is a non-coding RNA. In certain such embodiments, the target non-coding RNA is selected from a long non-coding RNA, a short non-coding RNA, an intronic RNA molecule.

A. complementarity/mismatch to target nucleic acid

Mismatched bases can be introduced without removing activity. For example, Gautschi et al. (J. Natl. Cancer Inst. 93:463-471, March 2001) reported that bcl-reduced expression of both bcl-2 and bcl-xL in vitro and in vivo. The ability of oligonucleotides to have 100% complementarity with 2 mRNAs and 3 mismatches to bcl-xL mRNA was demonstrated. Moreover, this oligonucleotide showed potent anti-tumor activity in vivo. Maher and Dolnick (Nuc. Acid. Res. 16:3341-3358, 1988) described a series of tandem 14 nucleobase oligonucleotides, and 2, respectively, for their ability to block translation of human DHFR in a rabbit reticulocyte assay. 28 and 42 nucleobase oligonucleotides consisting of sequences of canine or 3 tandem oligonucleotides were tested. The three 14 nucleobase oligonucleotides alone were able to inhibit translation, although at a more moderate level than 28 or 42 nucleobase oligonucleotides, respectively.

In certain embodiments, the oligonucleotide is complementary to the target nucleic acid over the entire length of the oligonucleotide. In certain embodiments, the oligonucleotide is 99%, 95%, 90%, 85% or 80% complementary to the target nucleic acid. In certain embodiments, the oligonucleotide comprises a region that is at least 80% complementary to the target nucleic acid and is 100% or all complementary to the target nucleic acid over the entire length of the oligonucleotide. In certain embodiments, the region of perfect complementarity is 6 to 20, 10 to 18, or 18 to 20 nucleobases in length.

In certain embodiments, the oligonucleotide comprises one or more mismatched nucleobases for the target nucleic acid. In certain embodiments, the antisense activity to the target is reduced by this mismatch, while the activity to the off-target is decreased by a higher amount. Thus, in certain embodiments, the selectivity of the oligonucleotide is improved. In certain embodiments, the mismatch is specifically placed within an oligonucleotide having a gapmer motif. In certain embodiments, the mismatch is at positions 1, 2, 3, 4, 5, 6, 7 or 8 from the 5'-end of the gap region. In certain embodiments, the mismatch is at positions 9, 8, 7, 6, 5, 4, 3, 2, 1 from the 3'-end of the gap region. In certain embodiments, the mismatch is at positions 1, 2, 3 or 4 from the 5'-end of the wing region. In certain embodiments, the mismatch is at position 4, 3, 2 or 1 from the 3' end of the wing region.

B. KCNT1

In certain embodiments, the oligomeric compound comprises or consists of an oligonucleotide comprising a region complementary to a KCNT1 nucleic acid. In a specific embodiment, the KCNT1 nucleic acid has the sequence set forth in SEQ ID NO: 1 (GenBank Accession Number: NM_020822.2). In a specific embodiment, the KCNT1 nucleic acid has the sequence set forth in SEQ ID NO: 2 (GenBank Accession Number: NC_000009.12 truncated from nucleotides 135698001 to 135796000). In a specific embodiment, the KCNT1 nucleic acid has the sequence set forth in SEQ ID NO: 3 (GenBank Accession Number: NM_020822.3), which is a splicing variant of SEQ ID NO: 1.

In certain embodiments the oligomeric compound complementary to SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3 is capable of reducing KCNT1 RNA in a cell. In certain embodiments the oligomeric compound complementary to SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3 is capable of reducing KCNT1 protein in a cell. In certain embodiments, the cells are in vitro. In certain embodiments, the cells are present in a subject. In certain embodiments, the oligomeric compound consists of modified oligonucleotides. In certain embodiments, an oligomeric compound complementary to SEQ ID NO: 1, SEQ ID NO: 2, or SEQ ID NO: 3 is capable of ameliorating one or more symptoms or characteristics of a neurological condition when it is introduced into a cell of a subject. In certain embodiments, the neurological condition comprises epilepsy. In certain embodiments, the one or more symptoms or characteristics are selected from seizures, brain damage, demyelination, hypofunction, microcephaly, depression, anxiety, cognitive dysfunction, and combinations thereof.

In certain embodiments, an oligomeric compound complementary to SEQ ID NO: 1, SEQ ID NO: 2, or SEQ ID NO: 3 can reduce a detectable amount of KCNT1 RNA in a subject's CSF when the oligomeric compound is administered to the subject's CSF. The detectable amount of KCNT1 RNA may be reduced by at least 10%, at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80% or at least 90%. In certain embodiments, the oligomeric compound complementary to SEQ ID NO: 1, SEQ ID NO: 2, or SEQ ID NO: 3 can reduce a detectable amount of KCNT1 protein in the CSF of a subject when the oligomeric compound is administered to the CSF of a subject. The detectable amount of KCNT1 protein may be reduced by at least 10%, at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80% or at least 90%.

C. Specific target nucleic acids in specific tissues

In certain embodiments, the oligomeric compound comprises or consists of an oligonucleotide comprising a region complementary to a target nucleic acid, wherein the target nucleic acid is expressed in a pharmacologically relevant tissue. In certain embodiments, the pharmacologically relevant tissue is a tissue and cell comprising the central nervous system (CNS). Such tissues include brain tissue such as the cortex, substantia nigra, striatum, midbrain, brainstem, and spinal cord.

VI. Certain pharmaceutical compositions

In certain embodiments, described herein are pharmaceutical compositions comprising one or more oligomeric compounds thereof. In certain embodiments, each of the one or more oligomeric compounds consists of a modified oligonucleotide. In certain embodiments, the pharmaceutical composition comprises a pharmaceutically acceptable diluent or carrier. In certain embodiments, the pharmaceutical composition comprises or consists of a sterile saline solution and one oligomeric compound. In certain embodiments, the sterile saline is pharmaceutical grade saline. In certain embodiments, the pharmaceutical composition comprises or consists of one or more oligomeric compounds and sterile water. In certain embodiments, the sterile water is pharmaceutical grade water. In certain embodiments, the pharmaceutical composition comprises or consists of one or more oligomeric compounds and phosphate buffered saline (PBS). In certain embodiments, the sterile PBS is pharmaceutical grade PBS. In certain embodiments, the pharmaceutical composition comprises or consists of one or more oligomeric compounds and artificial cerebrospinal fluid. In certain embodiments, the artificial cerebrospinal fluid is pharmaceutical grade.

In certain embodiments, the pharmaceutical composition comprises a modified oligonucleotide and artificial cerebrospinal fluid. In certain embodiments, the pharmaceutical composition consists of a modified oligonucleotide and artificial cerebrospinal fluid. In certain embodiments, the pharmaceutical composition consists essentially of a modified oligonucleotide and artificial cerebrospinal fluid. In certain embodiments, the artificial cerebrospinal fluid is pharmaceutical grade.

In certain embodiments, the pharmaceutical composition comprises one or more oligomeric compounds and one or more excipients. In certain embodiments, the excipient is selected from water, salt solution, alcohol, polyethylene glycol, gelatin, lactose, amylase, magnesium stearate, talc, silicic acid, viscous paraffin, hydroxymethylcellulose and polyvinylpyrrolidone.

In certain embodiments, oligomeric compounds may be admixed with pharmaceutically acceptable active and/or inactive substances for the manufacture of pharmaceutical compositions or formulations. Compositions and methods for the formulation of pharmaceutical compositions depend on a number of criteria including, but not limited to, the route of administration, the extent of the disease, or the dose administered.

In certain embodiments, a pharmaceutical composition comprising an oligomeric compound comprises any pharmaceutically acceptable salt of an oligomeric compound, an ester of an oligomeric compound, or a salt of such ester. In certain embodiments, a pharmaceutical composition comprising an oligomeric compound comprising one or more oligonucleotides, upon administration to a subject, including a human, releases (directly or indirectly) a biologically active metabolite or residue thereof. can provide Thus, for example, the present disclosure also relates to pharmaceutically acceptable salts, prodrugs, pharmaceutically acceptable salts of such prodrugs and other bioequivalents of oligomeric compounds. Suitable pharmaceutically acceptable salts include, but are not limited to, sodium salts and potassium salts. In certain embodiments, the prodrug comprises one or more conjugate groups attached to the oligonucleotide, wherein the conjugate groups are cleaved by endogenous nucleases in the body.

Lipid moieties are used in nucleic acid therapy in a variety of ways. In this particular method, nucleic acids, such as oligomeric compounds, are incorporated into preformed liposomes or lipoplexes consisting of a mixture of cationic lipids and neutral lipids. In certain methods, DNA complexes with mono- or poly-cationic lipids are formed without the presence of neutral lipids. In certain embodiments, the lipid moiety is selected to increase the distribution of the pharmaceutical agent to a particular cell or tissue. In certain embodiments, the lipid moiety is selected to increase the distribution of the pharmaceutical agent to the adipose tissue. In certain embodiments, the lipid moiety is selected to increase the distribution of the pharmaceutical agent to the muscle tissue.

In certain embodiments, the pharmaceutical composition comprises a delivery system. Examples of delivery systems include, but are not limited to, liposomes and emulsions. Certain delivery systems are useful for preparing certain pharmaceutical compositions, for example, those containing hydrophobic compounds. In certain embodiments, certain organic solvents are used, such as dimethylsulfoxide.

In certain embodiments, the pharmaceutical composition comprises one or more tissue-specific delivery molecules designed to deliver one or more pharmaceutical agents of the invention to a specific tissue or cell type. For example, in certain embodiments, the pharmaceutical composition comprises liposomes coated with a tissue specific antibody.

In certain embodiments, the pharmaceutical composition comprises a cosolvent system. These specific cosolvent systems include, for example, benzyl alcohol, a non-polar surfactant, a water-miscible organic polymer and an aqueous phase. In certain embodiments, such cosolvent systems are used for hydrophobic compounds. A non-limiting example of such a cosolvent system is a solution of absolute ethanol comprising 3% w/v benzyl alcohol, 8% w/v the non-polar surfactant Polysorbate 80™ and 65% w/v polyethylene glycol 300. It is a VPD co-solvent system. The proportions of these cosolvent systems can be varied significantly without significantly altering their solubility and toxicity characteristics. Moreover, the identity of the cosolvent component may vary, for example, other surfactants may be used instead of polysorbate 80™, the fraction size of polyethylene glycol may vary, and other biocompatible polymers may be different from polyethylene glycol, e.g. For example, polyvinyl pyrrolidone may be substituted, and other sugars or polysaccharides may be substituted for dextrose.

In certain embodiments, the pharmaceutical composition is prepared for oral administration. In certain embodiments, the pharmaceutical composition is prepared for buccal administration. In certain embodiments, the pharmaceutical composition is prepared for administration by injection (eg, intravenous, subcutaneous, intramuscular, intrathecal (IT), intraventricular (ICV), etc.). In certain such embodiments, the pharmaceutical composition comprises a carrier and is formulated in an aqueous solution, such as water, or a physiologically compatible buffer, such as Hank's solution, Ringer's solution, or physiological saline buffer. In certain embodiments, other ingredients (eg, ingredients that aid solubility or act as preservatives) are included. In certain embodiments, injectable suspensions are prepared using suitable liquid carriers, suspending agents, and the like. Certain injectable pharmaceutical compositions are presented in unit dosage form, for example, in ampoules or multi-dose containers. Certain injectable pharmaceutical compositions are suspensions, solutions or emulsions in oily or aqueous vehicles and may contain formulatory agents such as suspending, stabilizing and/or dispersing agents. Specific solvents suitable for use in injectable pharmaceutical compositions include, but are not limited to, lipophilic solvents and fatty oils such as sesame oil, synthetic fatty acid esters such as ethyl oleate or triglycerides, and liposomes.

Under certain conditions, certain compounds disclosed herein act as acids. Although these compounds are shown or described associating in protonated (free acid) form or in ionized form or in cationic (salt) form, aqueous solutions of these compounds exist in equilibrium between these forms. For example, the phosphate linkage of an oligonucleotide in aqueous solution exists in equilibrium between the free acid, anionic and salt forms. Unless otherwise indicated, the compounds described herein are intended to include all such forms. Moreover, certain oligonucleotides have several such linkages, each of which is in equilibrium. Thus, all oligonucleotides in solution exist as ensembles of conformation at multiple positions in equilibrium. The term “oligonucleotide” is intended to include all such forms. The illustrated structure depicts essentially a single form. Nevertheless, unless otherwise indicated, such figures are likewise intended to include corresponding forms. As used herein, the structure depicting the free acid of the compound before the term “or salt thereof” explicitly includes all such forms capable of being fully or partially protonated/deprotonated/associated with a cation. In certain instances, one or more specific cations are identified.

In certain embodiments, the modified oligonucleotide or oligomeric compound is present in an aqueous solution containing sodium. In certain embodiments, the modified oligonucleotide or oligomeric compound is present in an aqueous solution containing potassium. In certain embodiments, the modified oligonucleotide or oligomeric compound is present in PBS. In certain embodiments, the modified oligonucleotide or oligomeric compound is present in water. In this particular embodiment, the pH of the solution is adjusted using NaOH and/or HCl to achieve the desired pH.

Herein, certain specific doses are described. A dose may be in the form of a dosage unit. For clarity, a dose (or dosage unit) of a modified oligonucleotide or oligomeric compound in milligrams represents the mass of the free acid form of the modified oligonucleotide or oligomeric compound. As described above, in aqueous solution, the free acid exists in equilibrium with the anionic form and the salt form. However, for the purposes of dose calculations, it is assumed that the modified oligonucleotide or oligomeric compound is solvent-free, sodium acetate-free, anhydrous, and present in the free acid. For example, when the modified oligonucleotide or oligomeric compound is present in a solution comprising sodium (eg, saline), the modified oligonucleotide or oligomeric compound is partially or fully deprotonated and associates with Na+ ions. so it can exist. However, the mass of the proton is nevertheless calculated with respect to the weight of the dose, and the mass of the Na+ ion is not calculated with respect to the weight of the dose. Thus, for example, compound number 1080855 in a dose or dosage unit of 80 mg is equal to the number of fully protonated molecules weighing 80 mg. This would be equivalent to 85 mg of solvent-free, sodium acetate-free, anhydrous sodiumized compound number 1080855. If the oligomeric compound contains a conjugate group, the mass of the conjugate group is included in calculating the dose of such oligomeric compound. If the conjugate group has an acid, it is likewise assumed to be fully protonated for the purposes of dose calculations.

Non-limiting disclosure and incorporation by reference

Each of the documents and patent publications listed herein is incorporated by reference in its entirety.

Although certain compounds, compositions, and methods described herein have been specifically described in accordance with certain embodiments, the following examples are provided merely to illustrate the compounds described herein and are not intended to be limiting. Each reference, GenBank accession number, etc. described in this application is incorporated herein by reference in its entirety.

Although the sequence listing appended to this application identifies each sequence as "RNA" or "DNA" if necessary, in practice, this sequence may be modified by any combination of chemical modifications. One of ordinary skill in the art will readily understand that its reference to "RNA" or "DNA" to describe modified oligonucleotides is optional in certain instances. For example, an oligonucleotide comprising a nucleoside comprising a 2'-OH sugar moiety and a thymine base is treated as DNA with a modified sugar (2'-OH instead of one 2'-H of DNA). or RNA with modified bases (thymine (methylated uracil) instead of uracil in RNA). Accordingly, the nucleic acid sequences provided herein, including but not limited to those in the Sequence Listing, include, but are not limited to, natural or modified RNA and/or DNA, eg, such nucleic acids with modified nucleobases. not) are intended to include nucleic acids containing any combination of By way of further example, and not by way of limitation, an oligomeric compound having the nucleobase sequence "ATCGATCG", whether modified or unmodified, includes any oligomeric compound having such a nucleobase sequence, e.g., such an oligomeric compound comprising an RNA base. compounds, such as those having the sequence “AUCGAUCG” and those having several DNA bases and several RNA bases, such as “AUCGATCG” and other modified nucleobases, such as oligomeric compounds, such as “AT ^m CGAUCG”, where ^m C represents, but is not limited to, a cytosine base comprising a methyl group at the 5-position.

Certain compounds (e.g., modified oligonucleotides) described herein have one or more centers of asymmetry, and thus as ( R ) or ( S ), e.g., as α or β for sugar anomers, or e.g., It gives rise to enantiomeric, diastereomeric and other stereoisomeric configurations that can be defined with respect to absolute stereochemistry as (D) or (L) for amino acids and the like. Compounds provided herein that are shown or described as having a particular stereoisomeric configuration include only the compounds shown. Compounds provided herein, shown or described by non-limiting stereochemistry, include all such possible isomers, eg, stereorandom and optically pure forms thereof, unless otherwise indicated. Likewise, unless otherwise indicated, tautomeric forms of the compounds are also included herein. Unless otherwise indicated, the compounds described herein are intended to include the corresponding salt forms.

The compounds described herein include variations in which one or more atoms are replaced by non-radioactive isotopes or radioactive isotopes of the indicated element. For example, compounds herein that include a hydrogen atom include all possible deuterium substitutions for ^{each 1 H hydrogen atom.} Herein substituted isotopes contained by the compounds in place of ¹ H ² H, or ³ H, ¹² C instead of ¹³ C or ¹⁴ C, ¹⁴ N instead of ¹⁵ N, in place of ¹⁶ O ¹⁷ O or ¹⁸ O and ³² Instead of S, include, but are not limited to ^{, 33} S, ³⁴ S, ³⁵ S or ^{36 S.} In certain embodiments, non-radioactive isotopic substitutions may confer new properties in oligomeric compounds that are advantageous for use as therapeutic or research tools. In certain embodiments, radioactive isotope substitutions can make compounds suitable for investigational or diagnostic purposes, such as imaging.

Example

The following examples illustrate specific embodiments of the present disclosure and are not limiting. Moreover, when specific embodiments are provided, the inventors contemplate generic applications of these specific embodiments. For example, the disclosure of an oligonucleotide having a particular motif provides reasonable support for additional oligonucleotides having the same or similar motif. And, for example, when a specific high-affinity modification occurs at a specific position, other high-affinity modifications at the same position, unless otherwise indicated, are considered suitable.

Example 1: Effect of 5-10-5 MOE gapmer modified oligonucleotides on human KCNT1 RNA in vitro, single dose

Modified oligonucleotides complementary to human KCNT1 nucleic acids were tested for effects on KCNT1 RNA levels in vitro.

The modified oligonucleotides in the table below are 5-10-5 MOE gapmers with mixed internucleoside linkages. This gapmer is 20 nucleosides in length, wherein the central cap segment consists of 10 2'-β-D-deoxynucleosides, and the 3' and 5' wings each contain 5 2'-MOE nucleos. made by the side The motif for the gapmer is (from 5' to 3'): eeeeeddddddddddeeeee; where 'd' represents a 2'-β-D-deoxyribosyl sugar moiety and 'e' represents a 2'-MOE sugar moiety. The internucleoside linkage motif for the gapmer is (5' to 3') soooosssssssssssooss, where 's' represents phosphorothioate internucleoside linkage, and 'o' is phosphodiester nucleoside Represents liver linkage. All cytosine residues are 5-methylcytosine.

"Start site" refers to the 5'-nearest nucleoside to which the modified oligonucleotide is complementary in the human gene sequence. "Termination site" refers to the 3'-nearest nucleoside to which the modified oligonucleotide is complementary in the human gene sequence. Each of the modified oligonucleotides listed in the table below is 100% complementary to SEQ ID NO: 1 (GenBank Accession No. NM_020822.2) or SEQ ID NO: 2 (GenBank Accession No. NC_000009.12, truncated from nucleotides 135698001 to 135796000) . 'Not applicable (N/A)' indicates that the modified oligonucleotide is not 100% complementary to the specific gene sequence.

SH-SY5Y cells (neuroblastoma cell line) cultured at a density of 20,000 cells/well were treated with 4,000 nM of the modified oligonucleotide by electroporation. After approximately 24 hours of treatment time, total RNA was isolated from the cells and KCNT1 RNA levels were measured by quantitative real-time RTPCR. Table using human KCNT1 primer probe set RTS39508 (forward sequence GTCAACGTGCAGACCATGT, designated herein as SEQ ID NO: 11; reverse sequence TCGCTCCCTCTTTTCTAGTTTG, designated herein as SEQ ID NO: 12; probe sequence AGCTCACCCACCCTTCCAACATG, designated herein as SEQ ID NO: 13) The RNA levels shown in Tables 1-6 were measured, and the human KCNT1 primer probe set RTS39496 (forward sequence CAGGTGGAGTTCTACGTCAA, designated SEQ ID NO: 14 herein; reverse sequence GAGAAGTTGAACAGCCGGAT, designated SEQ ID NO: 15 herein; probe sequence TGATGAAGAACAGCTTGAGCCGCT, herein Designated herein as SEQ ID NO: 16) was used to measure the RNA levels shown in Tables 7-38. KCNT1 RNA levels were normalized to total RNA content as measured by RIBOGREEN®. Reduction of KCNT1 RNA is presented in Tables 1-6 below as a percentage of KCNT1 RNA level relative to untreated control (UTC) cells. Each table represents results from individual assay plates. 'ND' indicates that the % UTC is not defined for a particular modified oligonucleotide in a particular experiment due to experimental error. However, the activity of selected modified oligonucleotides, including those not defined in Example 1, is successfully demonstrated in Example 2.

Example 2: Effect of modified oligonucleotides on human KCNT1 RNA in vitro, multiple doses

Modified oligonucleotides selected from the above examples were tested at various doses in SH-SY5Y cells. SH-SY5Y cells cultured at a density of 20,000 cells/well were treated with various doses of modified oligonucleotides by electroporation, as indicated in the table below. After approximately 24 hours of treatment time, total RNA was isolated from the cells and KCNT1 RNA levels were measured by quantitative real-time RTPCR. Table using human KCNT1 primer probe set RTS39508 (forward sequence GTCAACGTGCAGACCATGT, designated herein as SEQ ID NO: 11; reverse sequence TCGCTCCCTCTTTTCTAGTTTG, designated herein as SEQ ID NO: 12; probe sequence AGCTCACCCACCCTTCCAACATG, designated herein as SEQ ID NO: 13) RNA levels shown in Tables 39-42 were measured, and the human KCNT1 primer probe set RTS39496 (forward sequence CAGGTGGAGTTCTACGTCAA, designated SEQ ID NO: 14 herein; reverse sequence GAGAAGTTGAACAGCCGGAT, designated SEQ ID NO: 15 herein; probe sequence TGATGAAGAACAGCTTGAGCCGCT, herein Designated SEQ ID NO: 16 herein) was used to measure the RNA levels shown in Tables 43-60. Each table represents results from individual assay plates. KCNT1 RNA levels were adjusted according to total RNA content as measured by RIBOGREEN®. The results are presented in the table below as the percentage reduction in the amount of KCNT1 RNA relative to the untreated control. The half maximal inhibitory concentration (IC ₅₀ ) of each modified oligonucleotide is also presented. IC ₅₀ was calculated using linear regression on log/linear plots of Excel data. In some cases, if IC ₅₀ cannot be reliably calculated, it is presented as NC (not calculated).

SEQUENCE LISTING <110> Ionis Pharmaceuticals, Inc. <120> COMPOUNDS AND METHODS FOR REDUCING KCNT1 EXPRESSION <130> WO/2020/190740 <140> PCT/US2020/022680 <141> 2020-03-13 <150> US 62/884,501 <151> 2019-08-08 <150> US 62/819,344 <151> 2019-03-15 <160> 2939 <170> PatentIn version 3.5 <210> 1 <211> 4782 <212> DNA <213> Homo sapiens <400> 1 agggcaacgc gagggaagaa ggtggcggct cccactcgct tctccctcgg gtcgggtccg 60 agctgccagg ccgcatgcca ctccctgacg gggcgcggac cccggggggc gtctgccggg 120 aggcgcgcgg cgggggctac accaaccgga ccttcgagtt tgacgacggc caatgcgccc 180 ccaggcggcc ctgcgcgggg gacggcgcgc tcctggacac cgccggcttc aagatgagcg 240 acctggactc cgaggtgctg cccttgccgc cgcgctaccg cttccgggac ctgctgctgg 300 gcgacccgtc cttccagaac gacgacaggg tccaggtgga gttctacgtc aacgagaaca 360 ccttcaagga gcggctcaag ctgttcttca tcaaaaacca aagatcgagc ctgaggatcc 420 ggctgttcaa cttctccctg aagctgctca cctgcctgct ctacattgtg cgcgtcctgc 480 tcgatgaccc ggccctgggc atcggatgct ggggctgccc aaagcagaac tactccttca 540 atgactcgtc ctccgagatc aactgggctc ctattctgtg ggtggagaga aagatgacac 600 tgtgggcgat ccaggtcatc gtggccataa taagcttcct ggagacgatg cttctcatct 660 acctcagcta caaaggcaac atctgggagc agatcttccg cgtgtccttc gtcctggaga 720 tgatcaacac tctgcccttc atcatcacga tcttctggcc gccgctgcgg aacctgttca 780 tccccgtctt tctgaactgc tggctggcca agcacgcgct ggaaaacatg attaatgact 840 tccaccgtgc catcctgcgg acacagtcag ccatgttcaa ccaggtcctc atcctcttct 900 gcaccctgct gtgcctcgtt ttcaggggga cctgcggcat ccagcacctg gagcgggcgg 960 gcgagaacct gtccctcctg acctccttct acttctgcat cgtcaccttc tccaccgtgg 1020 gctacggtga cgtcacgccc aagatctggc catcgcagct gctggtggtc atcatgatct 1080 gcgtggccct cgtggtgctc ccactgcagt tcgaggagct cgtctacctc tggatggagc 1140 ggcagaagtc aggggggcaac tacagccgcc accgtgcgca gacggagaag cacgtggtcc 1200 tgtgtgtcag ctccctcaag atcgaccttc tcatggactt cctgaacgag ttctacgccc 1260 acccccggct ccaggactat tacgtggtca tcctgtgccc cacggagatg gatgtccagg 1320 tgcgcagagt cctgcagatc cctctgtggt cccagcgggt catctacctc cagggctctg 1380 cactcaaaga ccaggacctc atgcgagcca agatggacaa tggggaggcc tgcttcatcc 1440 tcagcagcag gaacgaggtg gaccgcacgg ctgcagacca ccagaccatc ctgcgcgcct 1500 gggccgtgaa ggacttcgcc cccaactgcc ccctctacgt ccagatcctc aaacctgaaa 1560 acaagtttca cgtcaagttt gctgaccacg tggtgtgtga ggaggagtgc aagtacgcca 1620 tgctggcgct gaactgcatc tgcccggcga cctccaccct catcaccctg ctggtgcaca 1680 cgtcccgcgg ccaggaggga caggagtctc cggagcagtg gcagcgcatg tatgggcgct 1740 gctccggcaa cgaggtgtac cacatccgca tgggtgacag caagttcttc cgcgagtacg 1800 agggcaagag cttcacctac gcggccttcc acgcccacaa gaagtatggc gtgtgcctca 1860 tcgggctgaa gcgggaggac aacaagagca tcctgctgaa cccggggccc cggcacatcc 1920 tggccgcctc tgacacctgc ttctacatca acatcaccaa ggaggagaac tcggccttca 1980 tcttcaagca ggaggagaag cggaagaaga gggccttctc ggggcagggg ctgcacgagg 2040 gtccggcccg cctgcccgtg cacagcatca tcgcctccat ggggacagtg gccatggacc 2100 tgcagggcac agagcaccgg cctacgcaga gcggcggtgg gggcgggggc agcaagctgg 2160 cactgcccac ggagaacggc tcgggcagcc ggcggcccag catcgcgccc gtcctggaac 2220 tggccgacag ctcagccctg ctgccctgcg acctgctgag cgaccagtcg gaggatgagg 2280 tgacgccgtc ggacgacgag gggctctccg tggtagagta tgtgaagggc taccctccca 2340 actcgcccta catcggcagc tccccaaccc tgtgccacct cctgcctgtg aaagccccct 2400 tctgctgcct gcggctggac aagggctgca agcacaacag ctatgaagac gccaaggcct 2460 acgggttcaa gaacaagctg atcatcgtct cggcagagac ggccggcaat gggctgtaca 2520 acttcatcgt gccactgcgg gcctactaca gatcccgcaa ggagctgaac cccatcgtgc 2580 tgctgctgga caacaagccc gaccaccact tcctggaagc catctgctgc ttccccatgg 2640 tctactacat ggagggctct gtggacaacc tggacagcct gctgcagtgt ggcatcatct 2700 atgcggacaa cctggtggtg gtggacaagg agagcaccat gagcgccgag gaggactaca 2760 tggcggacgc caagaccatc gtcaacgtgc agaccatgtt ccggctcttc cccagcctca 2820 gcatcaccac ggagctcacc cacccttcca acatgcgctt catgcagttc cgcgccaagg 2880 acagctactc tctggctctt tccaaactag aaaagaggga gcgagagaat ggctccaacc 2940 tggccttcat gttccgcctg ccgttcgccg ccggccgcgt cttcagcatc agcatgttgg 3000 acacactgct ctaccagtcc ttcgtgaagg actacatgat caccatcacc cggctgctgc 3060 tgggcctgga caccacgccg ggctcggggt acctctgtgc catgaaaatc accgagggcg 3120 acctgtggat ccgcacgtac ggccgcctct tccagaagct ctgctcctcc agcgccgaga 3180 tccccattgg catctaccgg acagagagcc acgtcttctc cacctcggag ccccacgacc 3240 tcagagccca gtcccagatc tcggtgaacg tggaggactg tgaggacaca cgggaagtga 3300 aggggccctg gggctcccgc gctggcaccg gaggcagctc ccagggccgc cacacggggcg 3360 gcggtgaccc cgcagagcac ccactgctac ggcgcaagag cctgcagtgg gcccggaggc 3420 tgagccgcaa ggcgcccaag caggcaggcc gggcggcggc cgcggagtgg atcagccagc 3480 agcgcctcag cctgtaccgg cgctctgagc gccaggagct ctccgagctg gtgaagaacc 3540 gcatgaagca cctggggctg cccaccaccg gctacgacga gatgaacgac caccagaaca 3600 ccctctccta cgtcctcatc aaccctccgc ccgacacgag gctggagccc agtgacattg 3660 tctatctcat ccgctccgac cccctggctc acgtggccag cagctcccag agccggaaga 3720 gcagctgcag ccacaagctg tcgtcctgca accccgagac tcgcgacgag acacagctct 3780 gagccagccc tgcacggagc tcaggccacc aagcccgggg tcctcaggaa ggacgtggag 3840 gagcgtgtga ggacacggtg gcactagcgt gaccctgggg atggcacact ctactcacca 3900 tggctcctgg gactccaccc tggaaaggag cccctcatgc ggggggaggg ccagctcacc 3960 cctgggcacc tgcaggctag tgaggagagt tttttaacct atttttacac gtcgatgcag 4020 tccacttctc tttacacaca tgtaccgcaa ctcgtgacca gggctggctg ggagggcaac 4080 gcagggactg gacgccctac agggccgagc ccaggctgtg ctggagggtg gggctggggt 4140 gcatggggag gggagcagaa cccagaaccc aggagccccg cgtgggccac acccaactca 4200 gagccggcct gagcgttcac ggccaggcag cctcgcttcc ttgcagccaa gggctggggg 4260 ccagggctgc tgttctgcac tctggggtgg gtgaggggga ccctgggctg tttgctgtcc 4320 caagcccctt ctggaagtta gaagcagcaa agggcccggg gaagccgggc atgtgagagg 4380 ggtgcgtccc caggtccccc agagggccct gtcgccgagg acctttctga aggaagcaga 4440 agacgccatt tcctctactt cacactgaac tgtcccagcc actgcatcta gggggcattg 4500 ggcggaagat ggtgcatttc catggaccat tttacactta ccttttaaag caaagcctca 4560 ttttctaaac ccctgacttg tgaagcacaa ttcagcctcc gggctgggcc acgtggagag 4620 agaggatctt ctcagcaagg cgagatcccg ggcggcggct gacatcagga gcgccaccct 4680 gcgtcctttg ctgctggttc cttactggtt tgtacggtca gcgctggaaa cttctatta 4740 atggatgcat tctggaggca tgaagttaaa aaaaaaaaaa aa 4782 <210> 2 <211> 98000 <212> DNA <213> Homo sapiens <400> 2 tctagggggt gctcagccag ggaggatcag gagccccaa ctctccccca aattggcacg 60 gagcatctcg gcaacccatc aatgaacagg actcaggggc acaggagggc tggaaaggaa 120 ggcttgctcc tttccaggaa cagaataaca acaggtaagg cttgaacaaa tcaggaagtg 180 ccctgccgaa aacgtggcct gctctagccg tggagaccca gagggctgaa ggagacgggg 240 atgacagggg acacactgcc tgcaaggtgg tgagatgtcc catcaccgtg atgccggagg 300 actgacggcg tctaccctta caactcacag cgtgctgctc ctgactgggc cccagggcgc 360 tggcaagccg caggaactgc acagacatct ccaggaccga ggccatgtcc tcccgccggc 420 catcgaactg gggcagcagg gcccgcagac gctcacagct caacgacatc cgcttcctgg 480 ttccggtcaa gaaacaaata cctctgggcc ctcctgccct ccccgagaag ggacagcaac 540 tgctagaacc tgccagatag accctgggcg cttgtcaggc agagggggct acaagatgac 600 tcagagctgc ccccgtggtc tgaagccccg agatccacat cagagcacag cctgggcctg 660 acccctggac ctcggcgaca ggctgtccag cccaggccca aaccatggct gctttgcggt 720 gtggaaaaga cagcgagggt cagaggcagt cagaagcaca gagggtcaca ggtgcacagc 780 ctcaagaggc caaggcttca ggataaagag gggctgcagg atgttcccca acagggcttt 840 tctggtttac ttggagatgt gcagtctgtc cttctcctgg gcacaggcca cgagcccctc 900 ccagctgcct gacacctggt ggcagccccg aacataatct cacccgctcc acccctttac 960 agcgccctca cccctgggag gcaccaccac tcacctgcgc tccctctcgc tgatcacgtt 1020 ccgccgaagg caggagctgg gaccctcggc caccgtaggg gccttgggcg ggcccgagcc 1080 ccgggccgag tcctcgcagc aggagagggc accagacagg gagccgctgc cgagaaagcc 1140 aagagcaccg ggccctgaga accccagaaa aggccaccag gagtcccaga tgccagaatg 1200 ggcgtctttg gggtgcgggt ggaagccaag actgggtcac gtagggacac ggcccggccc 1260 tctctgcacc ccttcccctc tcccagggtc cagggctccg ccccaggagg cccaggatgg 1320 gtggagccca gcaacttgcg gaagaacccc tgggtacagg ccttgggccc ccaacccctt 1380 ggccgccagc ccaattcctc acttgcatcc cctgacggta gggattctgg agacctccgg 1440 gtagggctcg gagcaccggg acgccatgaa ctcgcagctg cggagcgacc ccacgcgcac 1500 ggccccttcc gcaggcagcc ccgccccctc acgtgtgctc tgccccacctg ccacgtgctt 1560 tccacctagc ccaccccacc cccacttgca atccgccccc atagcgcatg cgctctagcc 1620 ctccccacgc agccagcccg gggcccacgt gacccgcgtt cctgcaaaga aggtgctgga 1680 aagggactcg gggggtccac ccactctatg cccccgcagg acgccagggg aaggggcccc 1740 agcccaggtg gccctgcctc tacccttacc ttcccgggggg tcgcctcggt tcccacttat 1800 gcggtggtct cggtgccctt gggcactttg gagatgcggg ctctgccctt aggagcccag 1860 cccctggtgg gagtgggcgg gctgggctga gttgtttagc ccaggcctgg gggacccagg 1920 gacacaggga gggggaaggg tacccgcctg ctccccagtc gccccacgcct ccattttccc 1980 ccaaatctag tacgcttgca gacgctgcgc ctcagggtag ggtcaccatc cacacttctg 2040 ggtcgcccag aaccaggggc atcttgtccc caccccaggc caccatcgtc cgtgctcttc 2100 ctcccgctga gctctgccgg gcaccctcgg aaccgtctgt cccttcacct ggccctgccc 2160 aagcaccatc cccgctttat gccctggggc cccagctcga cccctcacct cacactctca 2220 acaggtttct gcgggatcgc gggggtcctg cccatccaaa ttcagaaagc tccggcgcca 2280 ggtgtttgct cacctccccg ctgaactcca ggagccgccc tgcgctgggc ttgagtcccc 2340 cagtacatac ttttgggggg atgacggagg gaagggggag gtggagaccc ttcctctttc 2400 acggaggttg cggggggccc tcagggaagc agaggggacg agggtggggg gtgaggctgg 2460 actgttggga ggacatccct ggcctggctc gtgctgaggt cgtagcggga ggaggtgggg 2520 tgggtggcag gggctctcct cccgagaggg gaggcaagaa ggagcccggg caggtgccac 2580 cacacgggga cgtctgtccg gggtgcccca gtctcctgtg gagaaggcgc ggctctgggc 2640 ctcgggctgg catcctggac tttgggccaa agatgggtga agggtgtttg gagcagaggg 2700 aggttatgta atataaggtg gtgtctccat ccctgctccg cccagccttg gctgcaggtc 2760 agacatggag gaggacgggg ttggagagga gggcaaaagc tctcggggac ctgggcccct 2820 ctcccggccc tgcccctggc cagggaggga tggacgggct ggcgatctgg ggctcctcag 2880 tggcagagtg gggccaagtt tttgtttccc taaagccctc ggaatgtcat caaacctgtg 2940 actctcctgc cgttgacaac acgtgtaatt actgctaatt aatcacagat gcagatggtg 3000 cggcctctca gttttttctg agttccccag gcaggagggc gttggcagaa aggccaccat 3060 cttgccccgg cggcacccgc ccaggggtgg tgggaccccg gcagcagcac cggccaatct 3120 agggacctga ggaaaaaccc ccaagatgcc cacgagctgt gtggcggggg cacaggctga 3180 acctctgctg gggacttagc atcctagact tccccgagtg ttccccaccc acccctcaaa 3240 agcatctgtg ttcagcctgc tgcctcctgg agaaacaggg aaggaccctc tggagagaca 3300 ctggggaggc cagggaccac aaagtacat gcatgcgccc tccaaatgga cctggccctc 3360 cccctggccc tcgtgggcac agtcctggct tagtgagggg cctggtccac cctgcaaacc 3420 aacaaagctc tggggacaga aatcgcagtt ctccagagct ctgtgtgagg ctgagccagg 3480 gtgacgcatg tgtaacagtg tgagcacgtg cacgggaaag ggggcccgca gggggaccct 3540 ctgcttccta gtctttggcc tgcagcatct taagttgggg cccctcccca cccgtctaaa 3600 ggtgctgtgt gtgcccgtct gggtgagagc acagggcggg gtgcagtcat ccccctcccc 3660 caggccaagc ccaggatgtg gcgcccaccc acagatgccg cagcctgcgg ggggtgtggg 3720 ggcgggggg cggggagtcg tcttgaatct ggcttgtgtt caatgaccag tgttgaccac 3780 ggcagagcag cacaagcggg aggtgctgac ggtccctggg cgcagcggct ggacgctggc 3840 ggtccgagca gcgcatgtgc cctgctgccc gccaaggacc cagagccccc tgagcccccg 3900 cccaccacgg agccctccca ggggtgtagg gcccggtggc ggcgcgcttg ggcttttcta 3960 gccattgacg aaccccgtcc tgtttttcgg agttttgagg gctcagaggg ccgcggcggg 4020 agcggatcgc cctccctacc ccgcaccccc gtcccagcct gggccagagc cgccgcgggt 4080 cccggcgcgg ccggcagggg gcgcgcgcgg acagacgcct gcacccgacc ctggaactgg 4140 cgtcttttcc tcgctaatct gcgaggaaaa aaaaaatgtt tttcagggca acgcgaggga 4200 agaaggtggc ggctcccact cgcttctccc tcgggtcggg tccgagctgc caggccgcat 4260 gccactccct gacggggcgc ggaccccggg gggcgtctgc cgggaggcgc gcggcggggg 4320 ctacaccaac cggaccttcg agtttgacga cggccaatgc gcccccaggt acagtctgct 4380 gcgccctccc cacgcgggga ggccccggtc taacctaaga cccccaagtt ccccctcagg 4440 ctcccgcacc ctccaggacc cgccattccc agggccatcc aacttcccca ggacccgcga 4500 gtgccctccc aaccaccttg gggaacaggg gcgcccctca gggtgggccg cactaatcag 4560 caggtgccga ggcagcagcg tccgtcccca tctgtcctcg acctggtaag aagctgggg 4620 gagcggccgt ggctacatgg gggtcctgag catctcccag gtgtggggag tggcagggag 4680 gctgggggcg gtgcagggcc ttccatctcc cccagcccct gccccacccc agcttgggga 4740 ggaaggttcc atccttcttg tgtggcatgg cagtgctcgg ccagggtggg gtgcccggcg 4800 aggttacccc acacagtagg gggtttccag agcaaccttc caaggaagag tccccagtgg 4860 gaagtgggct aagtggctgt cagatgaggg cgggagtcct gggttctggt cactcctcgt 4920 tccccgctgg cctatccctg ggaggagagg gccagttgag aatggcattc aggtgacctg 4980 gagctagctg ttccctgtgc agtgtcctgg gatgccatgc gtctgccgtc cacccagtga 5040 ccagtgcaga ggcacggacc ggcagctgag tgggacagtc ctgagcggag gttgccccag 5100 ggtccaggtt ccccatcctc tcccccatcc ctcagctctt gaaaacaggc aagtctgccc 5160 ctcaccctgt ccccagagcc agactccagg gaaccctggg cagagccggt cactgccttg 5220 ggcgaacccc tccccaccag gacagagccc tttcttctgg atcctgccca gtctcaggct 5280 gtcctgaggc cagagaaggg ggtggaagag catacctgag agcgggaggc ctggtgcggc 5340 tgcctgtttg ttctatggga ctcagtttcc ccgagtgtaa aatgaggagg tagggcggat 5400 ggtctttaag ggctgcctct ggtgagggac caggctggag aggaggttcc cagaatcaag 5460 aggcaggcac agcacccacc tggcacccgg gggagtccgg ggtacagcgt gtgtgaggag 5520 caggtgctct gagggtggac agtgacttgg tgatgtcctt gggaagtggg cacagcctgg 5580 acgtgctctg agggactatc cgggggatgc ctgtcaggca cagagaaaat gaccccaagg 5640 gggtcctgga ttgccctcat ctttgtgggc tggccggccc ctaccatctc cctccccagc 5700 ctagcgttgc cctccctggc cattctgctg gagtttatca cctaccctgc tgggcctgac 5760 ctgctccaga cgagccggca ggacagtgtc ctcagggtcc agcctttagc tccaggcctc 5820 atcctccggg tccttccaga cacctgtctc tcccaattgg ccctgcccac cggcccggga 5880 cagctcctcc tccccgctgg actgagctgg cctccgttgc aacagagatt ccctgtcaca 5940 ctgcaggcag agcagccgcc ggcagtggag ggatgtcagg cgtcaggctt ggggagggag 6000 caggacctgg gcttggctgg gctcgggagc ggggagctga gctccaggtg aggccaaggc 6060 ttgcggccca ggcaggtggc ttcagctgca gaaagaagaa ccttcgtgct gcctggtggt 6120 ggggggagct ctgtggggcg ggtttcccca ccagctctca catggggagg agggtgccag 6180 gcaacagcgt ggtcagaacc caggccctgg agtccatagg tcttggtgcc aggccttgag 6240 caggcctctg tctttcctgg gtgctggagg atgccagcct tggtgctatg gttcagaggg 6300 gccaggaggt gcttggacac cccaccccac tccagtgccc cagctcaaac ccccagctcc 6360 acgctagtgg tgtccctgag tcagcctcaa ggccatcagg ccggaaagtg gggctccaga 6420 gaggagctcc tggccttcca gtttgcaggg gtcttcacgg gcctctggcc tccaggctcc 6480 ctgctccccac ctccatgcca tggagtccca ggccctcagc tgcctcccca caggccctgg 6540 agatgacagc tgttgtagga cagggaggga ccagtggccc tggtggcccc agagctggca 6600 agtgcccacc ccctgcccag cgcacttcgc atcagagccc ctgccaggcc tttcctggaa 6660 ataccacttc ccagcagctg tgctccaggg cgggcctggg accctctagg ccctgatggg 6720 atcaggccct ggcatcctgc cagggtacat gcctggccca aggtcctggc cagccctcca 6780 ggcccatatt agggagcagt gccttcagca gcaggaagta gctcagggct catgggaaag 6840 gtttgagggc ccaagatacc gcccagcact ggccggcagg agggacggct caggccacag 6900 ggaactcagg ggtctgctgt ggcccaggag tggccacagt aacagctcag gaggacagag 6960 gtgagtgaga agggagcaga cagggtcccc acgagggcct ctgcttctgt tccagtggct 7020 ggcctgggtg tggcctgtgt cctcgcaccc ggcagcctcc aagtgtgctg gtctggttca 7080 cccaccgtat ggggagctct tgattaacac agaaaattac ttgggacgag cctggtgtgg 7140 cagtagtggg gccttgctgt ggggccatct catgccctcg gagggtgttg gggggcatct 7200 cgggctctcc cctgaggctt tttgtcctgc ttccccggga tgcaaacttg caggctttga 7260 cccaggtgcc atcggccctg gaaagggtgg cacttctgtg tctcccacaa acaatcccag 7320 gtttctctgc aacaggaaag tttgtccaag tgtgtcccag ccctgcatgg gtgagggatg 7380 ctgaacgggt atcgtgtacc caaaaacaag tgctgtgtgt gcatgtgaac ctgggcgctc 7440 cgtgagccag gcaggcgcac cgtgggcacg tgtgtgagag ctggaggagg atgtgtgggg 7500 cccgccagcc agcttgtgtg accttgaagt caccggtcat gagtctgggg aaaggcaggc 7560 tgggctcagc gtgcccgtgc taggtggctg ggtgccaagg cccggttaaa tgggcatctt 7620 tcaaaggtgt cttgggacct ctcccagctg tgtgtgtgga taaggccacc catgttcacc 7680 cagacccact ttcacctgtg gaacttggaa gtgagccagc ggggctggaa ctgaggccag 7740 gatgcgattg gcccagggag gtgagaccag tactagcagc tggcaagtgt aacaggtttg 7800 caggggacag tggcagggca gaggccgcga gcttcctggg gtaggtccct gggaaggccc 7860 tccttgagag ggggcctcca gctgctccct agatcggggg cgggaggtgg gggaggtggg 7920 agaggagggt ggcctcactg gagcagaggt gggggcatca ggagatggag ggcattgcag 7980 gaccagggtc tggactggca caaggcgggc gccccgggag gagcagaggg cctggaggag 8040 cttctgggaa ctgtgtctgt gaggttggtc catcccagca ctgagatgca gtagctgtgt 8100 cagctctggc gagtcacttc acctctctgg gcctcagttt cctcatctgt agaatgggag 8160 tgctagcatg gaccttacga ggttgtgttg agcccatgct gacagcacat acttggtgtt 8220 tacaaagctg tgttggcgtc gggagcttgc acaccagcca gttcgtcttt gccttgtcac 8280 gcaccagcct gtgttgacac gtcagagcta agcatttgtc cggtgacttc ccaagatgga 8340 ttcttaaaag tggaattgcc cagtcaaaag attcccacag tgttaatgtt tgccgcatgg 8400 cccacggccc ccaggggtga gaatggctcc tcctcacaac agtgccgggg tgtggtgtgt 8460 gccagctgcc accgtctcct ccttggcacc gtcgccctgg ggcacctgtg tcctgccagg 8520 caccactcag gcctcggagg ctgagacaca gctggcccct tggtgcccag gaaaggcaca 8580 caggcctcct cctttgtagc cactctgggg cactccacaa gaggggcaaa gagggcttcc 8640 atctgcctgt gactccctcc aggggccaga agtgggtcct catgcttcac aggcaccaat 8700 agtgcttttg cctggggcag accccagctg tgacagacag ccagggctca gaccaccaca 8760 cccagcagct ttccagtaga ttttcctgac cccagccaca ttgagggagg gggctggggc 8820 aggtattggg agcgccagtg agttggtcat tttctgagca tgatggcagc tcagggtacg 8880 ggcccctaga tggagcaggg gccctgtgcc tcagcctccc taaagtggcc cagccctccc 8940 agagttcatt ggtgctgagg aaatgaagcc tcacttgtgc ctcagttccc agacaggccc 9000 aaggccaggc acggtgggtc atgcctgtga tctcggtgct tttggaggct aaggcgggag 9060 gattgtttga ggccaggagt tggagaccaa cttaagcaac atagcaagac ccctgtctct 9120 acaaaaaaaa aaaaaattaa aaattaagat cagataaggc ccggtgcacc cctgcaggcc 9180 atgccagccc tcaggtgctc agcatggcca gcccagggac ctggcacagt tctctggggg 9240 aatgagcagg ggcatggtgg tgcctcccat agctgtggga gaggggcggc ttctcctcca 9300 ggtgcagccc ccaccacggc ctccccaccc tcaggctgtc caccctagga gggctgtccc 9360 caagggtccc ctgccggctc caggctgtgc tccttgctat gatcaccatt gcccccagca 9420 gccagctcag ctcgagggta ctgacagctg acgtgtgcag tcactaagca tctcccagca 9480 gccacagcgt ggccgggggc aggggctgtg ggccgatgca gctggagaac agggtgtggc 9540 ctgtgagaag gaccagccaa gggtcctggg cacccagggc ccaggaccct gagatggact 9600 tgccatctga ccctgagtga ccagcacact gctgcctgct gcagggggtg gggacagcag 9660 aagggctcgc ctggcgtctg gcccaagccc aggcttctgc ctcccccgac aaccttgggc 9720 acgggtccag gggtgatggc ccccacagcc tcgcctgggg cccctgtgtc cactgtgctg 9780 ctggccttcc cctcttcccg ccgggctggg agaaagctgc tctgaagtct gtctggataa 9840 atctacagct tgatttcggc tcctccatgt gttctgagct ttcactttgg atcctaaagc 9900 atctcaggag atggtgctga gcagccaccc tcgcatgggc aagaagcccc tcccctaaag 9960 agagacgtca ccgaggacgc ttgcctgccc agctgcctgg gcatctcgag cagctctgac 10020 tttttaatca tcgtgcaaag gaagcgttga gttttctgcc atggtcagca gagaggttct 10080 gcagctttgc acttgctgga cactaagccc agcactcaga cacccccacc acagtgatgc 10140 tatgcctgcc tgggggactc tcctggatgc agggtaggga tgcccacaca catacaggca 10200 catgcacaca gatccatgtg catgcacaca tatgtccaca tgtgcacatg tatacatatg 10260 cccatgtaca tgtatgcata catgcacatt gtacatacat gcatgcaatc ccatccacac 10320 atgcatgcac atattcgtac acatgcctct gcatgcaaat acatgctcat ttacaacacac 10380 atcagcatgc atgtgcgtat ttacgtgctt acatgtgctc atctccctcc tccctaactt 10440 ctctgtcaaa catggctcgc ccagctcctg gaaattttga actgagtgtg aacaagaatg 10500 tattttagga gagaaacctc attcccttag ccaaagacag tcacaatctt tttttgttgt 10560 tgttgtttca gacagaatct agctctgtca cccaggctgg agtgcagtgg cgcagtcatg 10620 gctcaccgca gcctcaacct catgggctta aatgatcctc ccacttcagc ctcctgagta 10680 gctggaacta caggcaccat gcctggataa cttttgttat tttttgtaga ggaaggtttt 10740 tgccatgttg cccaggctgg tcaggaactc ctgggctcaa gtgatctgcc tacctcgggc 10800 tcccagaatg ctggaattac aggcgtgagg caccatgctg gaccacaagc aatgttaaga 10860 gaagtctttg cgggaaagga cattttatcc aggacttcct atgctgatcc tgagaggcag 10920 gctccttgct tctttctgag ccccacccgg ggcagaaata agggcctggt gatgctggag 10980 tttagggaag gacatcttta gcccttagct gttccgtttg ccataacaca catcgtgcat 11040 gatgtattca ctttgcaaag cacaatgggt gagacgctgc cctagaaccc caccctgccc 11100 ccagcactgt ggctgccagt gtgtggggac agtctctata tcacctacaa gctgggtgcc 11160 cagagaaacc cacctcttct ttagggttct gtggaaagcg gtcgtgttta gtttttaaat 11220 ggggttcatt atatgccatt ctgtttgtgt agtgatgcat ccacacgggc tcacgcaggc 11280 tcacagagac ctgtgccttc acagagcagt cttggctgta gctgtcagtc gctcctcagt 11340 tcagggacgt gcaggctgtt ttcagtgttc accttcacac atgaggccgt gatgaaaatc 11400 catgcctggg cctcctcggc cacagatcaa aaatgtcccc aggtagaggt tccaagttgg 11460 agaggaccca cgattccatc ataattaatc cactgctccc agtcggctgg acactacatg 11520 agagccctgg cttgcagaac cccccgttct gtaaccacag ccgatcactg gcgcaggaga 11580 ccgtccaact ctgcatctct ctaattatta gctaggtggc ttgtctttac ttgtgcgttg 11640 ttttccattc ctcttctttg aacctcactc atccatcctt tgagtcgttt tcttttttga 11700 gatggagtct cgctctgtca cccaggctgg agtgcagtgg tgcgatctca gctcactgca 11760 acctccgcct cctgggttcc aacaattctc ctgcctcagc ctcccgagta gctgggatta 11820 taggtgtgtg ccaccacaac cagctaattt ttgtattttt agtagagatg gggtttcacc 11880 atgttagcca ggctggtctc aaactcctga cctcaggtga tccacccacc ttggcctccc 11940 aaagtgctgg gatgacaggc ttgagccact gcacccggcc atgttttctg ccagattgtt 12000 ttcctttcca cgggacctgt aggcaccagg ctgtgttctg atgattattc tgttgcaaat 12060 atgttcttcc tgttggtcgc ttattctttc cttttgccag tgatgtcttt tgttaaacag 12120 cagtgttttg ttcagatgta gaagctttta taaatctatt cctcttggaa tagatgattt 12180 ttgggtttcg tgtattaaat aaaaggcctt ctcagctctg aacacttttc cctgtatttt 12240 ctttccatct tgtccttggt ttggggctgc agatggggtc taatcttatt ttatccaaca 12300 gaagacactg catagcatag gctggagcca ggtactgggt tcaagcaccg gccctcccaa 12360 ggcaagggga caagtgataa acaaggacaa ataaggaaca aggtcaagtg catttctgaa 12420 gttctccggc ctccatttct ccatcaacac aatgggaagg atgtcgcccc tcctgatatt 12480 tgcaaccgtg acttgagtca ggacaggtgg agctgcactc gttccaatac cataggacga 12540 ggagtgcccc ccgcctcctt tctcaagcct ggattccaac gtgggcttca gctggtcaag 12600 gcactctgct gtgtctcccc actctctgtc ttttcttggg ccagaccgca gagtgtcagc 12660 tgctgtggct ggacattggt gctggcagca gaagacgagg gccctctctg ttccttttca 12720 caactgctgt ggctgttctt gcacgtatag tcttcaggat taatttttga aacagttcat 12780 caaattctga gaaaatagtg atgcgctctt gattggcggc gattcccttt acccgtgtgt 12840 ttggagaagg gactgttaga ccctcaggaa gaagacctcc gtcttccgcc agcgacagct 12900 tccagtccat ctctcaggaa cgctgtgcgc ccctgtgggt ttggggctcc cgcgcctgct 12960 gtgagcaggg ctttctcccg gtggctctct gctcctgctc tccatggtgc tcctgggttg 13020 gccgccatac taggttccgt atttgctcta gtaggttttc agttgattcc tcttgggttt 13080 tccagtaagc aatcatgcca actccaaaca gagccccctt catgactcct tgcttttatc 13140 ctttttctcg cagcagtgca cagatgaggc ctcctttatg atggcaaggg cagcctcaca 13200 ttcccaactg gaacgggaat gcccagagcc tttggcggga gaagcttgtc tttaagcact 13260 ttgtcagaca gccctggctc catggccacc gggaacagat gcagggggag tgagaagcag 13320 gcactcctgg ctatcagaag agccccccag ctggccaaag gcagcacagc ccaaggtgaa 13380 cctggacctg gccccccaccc cagtgcctct gccgggacct cagtgacgct ccttgggctc 13440 tgggagccac ttgtccttgc caggaactag ggatggagac tggcttctga gaactgttct 13500 caggattcca tgccaccacc tggcttgcca gggtgcctgg cgtgcagctg gctctcagtc 13560 catggcagct ggcactgagc acagctgccg ggctcccctc tgatggggtt gtcagggtca 13620 gtgcacgtga ctacgtgtgc accaaacagc tgacggggac ttcctgttgc cgtgcccagg 13680 tgtggactgc ctcgctcatt cttggcctct ccagatggat tccaaaagtc agtgtcccaa 13740 gcctgagctc tctgatgggc ctcagctgag cggagggggc acgctgggcg ccggccaccc 13800 tgggtcatag cctttgtcca taagagctca gccaaactgc tggccacgct acacctgctg 13860 tagctgaagc actcacctgc aggccctgtt ccgcgtgcct caggcatgct gtctggttac 13920 atcttcacac tcttcctata agggaacagg catcagtatc tcccttcacg catgagcata 13980 caggctcagg gaggtgaagt gactcgccgg gggccgccca gcaggactga tgggccagga 14040 ctgaactcat gccagcggga ctcttgccac tctctgggcc tgcagggtgt gtgctgacag 14100 cccagagagt ccccaagagg agcagcgggg tgctctgagc ccctgggctg ccccggcctt 14160 gtctaggggg tgtgctgtgt cccgtcacct cagccctggc tccaaggggt gtgtgagtcc 14220 cacaggttga gctccacacc ttgtccagag agtagtgtaa gggctgagga gagggacacc 14280 ttccttaagc caccaaacac agaattctta tggaaattgg taattatttg gcacagcagt 14340 cactcagaaa ataaaaagat catggatgtg gccttggggg tcctagattt cctccagggc 14400 cccttgggtc acacagggag gacagcgcaa gagaagaggg ggtgcagaat tcgaggtggg 14460 ccccagggtc cccgtgtctg gctatgccag ggttatgttc cagttccacc tgaaccagct 14520 tcaacaggga ccagaccccc caacactccc ctctccccct gtgcccaaaa aagctggccg 14580 atgtaggcct tcctgcttgc gaaaagtctc aaccagaccc cgaggacacg gggagcagct 14640 gttttgctgc tgtcctcctg cgatgggccc ctttcccaga gaccctgtag ccccggccct 14700 cagtcccagc cctcagccaa cacaacagcc aaggatttta gccccggccc tcagccaaca 14760 caacagcgaa gtattttcaa ggtttctggc tctgtggggg gaacaaggca ggatgccagg 14820 aggcctgcag gacacctgct tatggccgtg tgctcgctca agtgtcaaag cagcttccca 14880 agggaagaag ggcatcttgt ccttgtcacc ctccccaggc cacatctggg gagcaggggt 14940 ggggccaggt ctctggactc ctggtgcact tccttcccct ggtgactcct gaagcaagcc 15000 aaggtccaag cccctgagct tgtccatggg ccctgccaag actgggcctt gaggccagga 15060 ggaggaacca gagccgctca aaaggcagac ggggtgggga cgggaggagg cagccacgcc 15120 tgaggagccg gcagtctctt ggggttttgc cattgaaagg ggctttcagt gaggaaggca 15180 caaaatcaag aaaatagagc cccgacccct ggccacgtgg ttcccctgcc tgcctgcacc 15240 tccccatggc ccagccagct tgtgactaag gaaaaacatg cagctacgct gatgcagtta 15300 ggaaaatgtt attttttaaa tgctgccaga tcctgggggt tgaacctgtg acctcagaac 15360 aaggagcagg gtttggggca cgcacctgct gcctgcagct tcagcctggg gtgcccatag 15420 ctccttgcct gctgcttgtc tgagggttag gggacacagg agaggcactt ggtgggggct 15480 caaggaatgt gccccacccct cccgacttga ggagagagag gagagttttg tagcatccct 15540 ggacctggtg ttccaaatga gtggcctctg tgcagggcct acgggcacag cacggggagc 15600 tgggtatggt cagagcctcc tgcccctgcc cgtgggggag ccagccccct ccatcccccc 15660 tctgctctcc tgctggcctc gaagccttga acaagggccg gcctgggcca ggtaaggagc 15720 tccctgcccc tcagctcctg cttctcctgg agcagccaaa actcacttca gtgggggaca 15780 tggggacagg aaagatgcaa gacccctgga agacacctgc ttgggccccc aagaactgca 15840 gaccaccagg ggtcctccca ctctacctgg tgtgccacga tgcccctaac ctgcgctgcc 15900 agctctctgt gtccctttga tccctcacct ggtgacagtg gcagggcagc tcagggccca 15960 gagggcctgg cagccccccg gggttctgac ctgagctgag ctgctccgcc tggggaggct 16020 gcaaacaagg gtgtcttctt aggcctcctg gtcactccac cctcacccct caacagcctg 16080 agggtctgag acgggggtct ctggggctgg accctgaagg aagattgagc agccggcctc 16140 ggcaaagacc ctggggacgg ggaggggagc tggggagttg ggaggggttg caggggtgtg 16200 gcggggcttc agagcagggg gagggcctcc atcctggctc ttgggggatc agggaggagt 16260 ggtgcgcgcc tgtccctgag ctggccatga cagctcccgt cccccttacc tcctgccagg 16320 ccccggggcc gctttggagg gagccccgcc ccctgcccct gcgcagcccc cgccctagcc 16380 ccagcccggc gcagccggtc ccgcgcgccc ccgcccgcat gtgccgccag gcccgccccc 16440 gcccggccgc ccgcccgccc ggtgggtcgc ggtggccgcg ggctgcgctg cgcgggccgg 16500 gcctggcggg ccgggggctg cgcgcgtccg cgagggcgcc cgacgcgggc tgaggggcgc 16560 tggcgtgtgc ccgcaggcgg ccctgcgcgg gggacggcgc gctcctggac accgccggct 16620 tcaagatgag cgacctggac tccgaggtgc tgcccttgcc gccgcgctac cgcttccggg 16680 acctgctgct gggcgacccg tccttccaga acgaccacag gtagggaccg ggcgcggggt 16740 gggggctggg gtcgccgtcc cggcgccgcc gcacgcccgg agctgtccgc ggtgctgacg 16800 gccggtcccg cgcgcccccg cagccgccgg cgcccttcaa cttttcccgg cttctgggga 16860 cgcagaagtt tcggaggggg tgcgggcagg gggaagcatc ttctcgggag ggggtctccg 16920 gaggagggcg cgggatgctc ggagctgcgg agtcttccag agcccgactt ggggcgcgga 16980 ggcggagggc ggcctggcct tccggtgtct gctcccaacc cccagcaccc cagtttttct 17040 ggttttgggg gcaagccagg gccggaagcg ccccggtggc ggagcccgca gcctggctga 17100 gggctggcgt cctccaggct caggcagcgg tccttgatta attattcaat gagggagctt 17160 gtccttcagg ttcgtgacct ggtcacttat tccgagtcac cgtgtccccg tcccctcaac 17220 atctcctggg ctaaaaaggc aaaatgaatt gtgtctttca gttaaggacc aacaggatga 17280 gcccatggga ataattcatc cgctgagggg gctggcagga agctggaaga aatgttgctt 17340 ttctctcctc cttttcccca aatagctgtc ttgggtaaac acccagcact ttagctctgc 17400 caggctctgg ggaggcgctt ttttgcctgc aagtgaaggc aagtgctctg aggactcacg 17460 cggagctgga gcccgcgggg gcttcaggtc aggaaccgct cctcttccag cgtgtagggt 17520 acggcagggt cggggttgtc actgtctcca gggctccgtc accacccagc cctgggctca 17580 gctagcaaat ccgcactttc ccccaacaac gcagttattc cggttagcac acaaagtaca 17640 cgaggttgaa aatggtcagg acacaaacag ctttcagaat aatctactgc tgaaaccgca 17700 gctgaaaaag aaatcatgtt tgtaactaga gtcagtccta gggactgtat ccatgaggac 17760 catgaagatt tgtaaaaagg gggtcttaaa acccctctgc ctgcggggaa tggaatattc 17820 taccagacct cccataacat ttggttgtgt gaaccaagag tcaggagtgg ggactgagcc 17880 cagtcttcat ccactcagaa tcagggagtg agcgtcctgc agagaggcct tttaaacttg 17940 gtttttcatc ttgttgaact cagtgctcta ataatgagcc cacctaagtg caaatgccca 18000 ggtgaagagt ttagtttatc tccctgtgtg ggcagagggc agtcagccag gctggtccca 18060 gggcggcgtg cgtggctggg aggctctcct gggagccaca caaagcttcc ctaggccgaa 18120 tccgtggact caacatcttt ctaagccagc accagcccct cagatgcctg ttcagctggg 18180 acttggttaa ttcttgaaaa cggcagccct gggagatcct tccgatattg ggcaggaagt 18240 ggtgtccatc cgcctaatgg tgcctggggc tcccagatga ctcgataacg cctgtggctg 18300 tggttgatca aattgtaatg ctgtattcct gagtgttcag gagtggacag cagaggcttt 18360 tgctgtccgc ctagagagaa ccatgcccat ccctgggaga ggagaagctg gcatgggatt 18420 tcacaatgag tccctgatcc tgggtgtggt tttttaaaat tgtggtaaaa tacataaaac 18480 agaatttacc gttagtgaca tttagtacac aacactgtgc caccctcacc actgtaattc 18540 gagaacattt gtatacccta gaaggaatct ccttaaccac tgggactcac tccccaatgc 18600 ccccttatcc cccagcccct ggcagctacc gatttgcatt ctagcggtct tggcgtgctg 18660 tgcccactgg gcacatgggt tgtgtgccga tggtattagg aggtggaccg ctggacgtgt 18720 gtggctgtgt gtgctagcta gtgcgtggct gtgggtcctc tccaggaaag gcccatgggg 18780 tacagggcat ctgtgccacc cccacaagtg ccctgctctc tctggttgga aatgaagtat 18840 acagtgaggt tctattggag ggagagtggc cagggattag agcttcgggg ctgtgtggtc 18900 gccatacctg tcctgtggcg ctgtccctca agatggcctc agagatgctg tgctgcatac 18960 cttttctcat gtgtgaagga tgggagtgga cctggccctg tggtggtggt gtgcatagga 19020 cgggagggga cctggcccct gtggtgttgg tgtctatagg acaggagggg acctggcccc 19080 tgtggtattg gtgtctatag gacgggaggg aggggacctg gccctgtggt gttggtgtgt 19140 ataggacagg agggaggggga cctggccctg tggtgttggt gtgtatagga tgggagggag 19200 gggacctggc cccagtggtg ttggtgtcta taggatgaga gggaagggga cctggctctt 19260 gtggtgttgg tgtctatagg atgagaggga aggggacctg gctcctgtgg tgttggtgtc 19320 tataggatgg gacagggagg ggacttagct tccctctgag agtggttccc cacttctcac 19380 ctctgagagg aagcttgggc ctggtggaga tggtggcctt gggcaccccg agatctggaa 19440 ggtggggggc tgctggtcgg ctggtgtcca gcccggttcc cagcagcttt gcctggctcc 19500 ccctggaggc tgcgggggct ggtgaggctg gctgggcaca gtacaggagt gggcaacttt 19560 ccgggggcgc aggggcaagt gagttggggg cttctgccca agtcacctgc cagctcgcca 196220 gccgctgccc ggcacagctg aacccgctcc tcacgtggac tcaggccctc ctgagaaatt 1980 gcctcgactg gatgtaagag agggtgccct agaggcctag gagcccgggg aacccccact 197440 taccccaccc aggaatggca gctccttggt ctcagcagca gcctgggggc ctctcctctt 1800 gaaggcagct cagggagcct ggcctgaagg gtttctcttc ctcaaacctt ctttgcccaa 19860 aggggcttgc ttcagcctcc atggtagggt tgggtgagtc tggcatggcc tctctcatga 19920 ccccgatgct ggaatgggtg ggcaacaatg agggaaatca ggatgctgac aggggtcctg 19980 aggtcaccca agccctcccc tatccataag gacacgcacg tggggacccc agccctggct 20040 ctgtggaaac cccaagctga cctggaggag gggatcagcc gcttggagga ccctcctggg 20100 tgcttggggt ggggtctgat gcctctatct gccattagaa gccatcccat atctcctcat 20160 cttcctcctc atccccagtg cctgtgcctt ccccttcctg gagtggagac caggggtcgt 20220 ctgcctggcc tggtgggacc cccttcctgt gtactgcagt gactcacagg agccgtgtga 20280 ggtgggagga cgtgcttatc tgaatgcagg agggagtgca ggcggggtct ggaggccata 20340 gggggcccag gtctgaaagg gctgagccca gcaagacctg cctgccggct ctgggtgaga 20400 aagcccttag gtagagggga ggggacactg ggatggggtc ctgggctgtg gacggaaggg 20460 ctggtgtgcc cggacacggc agcacaggct ccactcgggc ccctgaggga ccatcgtggt 20520 ggccttggcc atgggggtgt ctcaggtctg ggtaaggtgg aagtgccgct tggtctctct 20580 ctgcaccagg ggaagagatt gaggggcagg gagacccaac catcagcaca gggcaggtgc 20640 aatgtggggg ctcagcacag actggcaccc ctcacgccct ccctatttct accctggggc 20700 aggctctgtg agggaagcgg gtgctgctgc caacccctgg caggctgtga gcgagcaggt 20760 gggcgggcag gactcgggct tcctgtttcc cccgggagta gagcctctgg cagtgagtca 20820 ccacagcctc catcgcccgt ggccttggac agagaagagc tcggcgggcc atgtgggcag 20880 aggaggctgt actgctgggc aggccgctcc cagcggggat gacccagccc atcggtaccg 20940 cccggtggag gaagtggaca gagttgggag ctcactcacc tcagggacct gatggtggac 21000 cctcaccact gcttaccaga tggtgtctcg ggtgctccca tggagcagca ttcagccaca 21060 gtccacctgc gcccaggctc tggagcccct tgagccatgc tgacagtctc actgcccctc 21120 tgcctgggag tccaggggca actgatggag gccctggccc tcccagccag agccagctct 21180 caagagtgtc ccggaagcct aagtgagcgt catggccctt ggaggacaca gacttgggct 21240 cttcttctgc agaggggtta acagccccca aagggcagct cgaggagcca gcgggacagg 21300 ggctgcctga gggcttgggt cctgacggtg tccccgagct gggtcccagg caccttgtgc 21360 agactctggt ctgtggcagt ggaggtgcgg cttccatcct gccctgcact gaggctcagg 21420 aagatgctgt gtatgtcggg ggatgcatgc tttggggaca cttggggctg tcacaccaca 21480 ggcccatctc tccaaagggg cagattccag acaaggagtc ccagtgggga ggggtggggc 21540 aggcagccac cccccgccat gctgcaccag gacccagccc accggggcca ctgaagccac 21600 cactggaggc aacgtcaggg tcgccaacac tcccaggcat taagcaggac atgagaggtg 21660 ccaggaaggc cctgcccact ggctggggct tccggcaggc aagaggaagc ttcgtccctg 21720 agcatggcca gggccactgc cttggctcct tgggccaccc caagctgagt gccccaagct 21780 ggtgccatgg ggcccaggca ccagggtcac ctgggaaggg agtggccgcc ttgccacaga 21840 aagcccggcc ccagtgcagg cctcccgggg tcagaacact gccccagagc ggcctgacca 21900 ggctgtttca ttagctcctc tgacaacaga gaacggaact tgacttggtt ctctggagtt 21960 gagcaacacc aaatattttt tcacacaaca agctgagaag tggaccacaa acagggcccg 22020 gcattgctgg gaacacgggg cagcgggcct gcgtggagga tggacccctg ccggccccac 22080 aggcagcaac tgtggatggg ccaggcaggg ccagcaggag caggaatggg tgcagaagga 22140 gggggcagcc cagacccctc cctggccctg ctggatgcac cccttccatt cacccgaccc 22200 taccccacag tgaatccagc tgccccgcag ggacagggta gctgggaaca gagagaggct 22260 tctctcacag ggtgaaggcc ccaccaggcc tccaagcaga aggggttgcg gtggggatgt 22320 ctctaggaac agccctgccc tccgagccct catctgtcat ccttaatagc tgaacaattt 22380 ctcagctggt cggggaagtg ccttgagacc tgggtgactc ggtgtgctga gggccttcta 22440 gaatcatccc tcctgcgaag agcctgggat tgcataagtg ccctcctcct gcccagccct 22500 cccagctcca tcatctcttc ctatcccctc cccaccccca tcatcctgcc cccacacacc 22560 agcctggccc ctgctgaaga agcagggggc ccaggcagcc ttcctccaga gggagctttg 22620 ctccgcctct cttggggctg ggggcggggg tcctgcctgt acccccaacc ccacctgctc 22680 tctgaaggcc actctgggac cctgagctga gaaggcccgg gagccagccc cagctccctg 22740 aagggcactg agcccagagt ttctgcgtga aggcgtgagt ggcctgggca ggacctaggg 22800 cacaggtcag ctctccttcg ggggtgctct ggggaagcta gggctgggct gcgcctgcac 22860 caccctgctc ctgccttagg gccccaggtc cccatgtgac agactcaggt gtagctggag 22920 ctttgaaaca gagggggaca gtcaggagga agggtgtggc caggcctgac ccaaaggtga 22980 gggtggggca cgagggacac acggccgagc ccaaggggca gtggtggttt aggggccgtg 23040 aaggttcgag gaggagtcgg ggaaccatgc agggtgaggg ctggggtggg agaggcctgg 23100 agctgagttt gggaagggtg gcccctggac tggggggaccc ccagaagggg ctgaagtggc 23160 ccccaacgct ctcggcctga gctgctgggc cagccccagc ctcgaagcca ctccgctcca 23220 gcaccgggtc ccctggcgtg cctcctgccc agagctgctg agctcaggga aacgccagcc 23280 tgctcagtcc ctgggggtgg tggggtaggg ggtggttata tttaacattc tgcccggggc 23340 catcctgctg tgtgcaggcg tactaatagg gcagggaggg gccaggtggg atcccagtcc 23400 tgcccctggc ccttctcgcc ctggggccct ttccagagca aacacccaca ggcttgggag 23460 gacacggcca gcctgagaaa tggccttggc caggccggtg gggcccaggc aggctggggt 23520 ctcctggccg ggggagggtg ccggccatgc gcataccagg agccaatccc agagcctcgg 23580 ggccgcctgt ctgtctttcc tggaccccct tggtgtgcca cctgcatgat tgagtcaagg 23640 tctggtttat tggagcagga aaggcccggg atggtgtcca aaagttctgg caggttccat 23700 gtgctttacg gtgtcctgag tgagtgaaat gcatgtcatg atttctccag tccctttcca 23760 gctcagggtc ggtttgcctg tgttgccccc actcgactgt ggacagggct ggaggccagg 23820 cctgctcgcc cttgtctcct gggcccccta ccaggaagca gggtcctgga aggtgggcct 23880 gagtcagggt gggggaaggt gacgcctctg ctgtggagac tgtggctccc gggtgggctg 23940 caccttcctc ctagccctgt ccctccctcc gacggtgggt tccaggggct tgcgttgcct 24000 ccagccctgg gtgaccaagg agtgggcagg atcaacagga gggccacaga ggctgtcggt 24060 gaccagggcc catcacatgt gaacggtgtc ttgtggggca tcacctggct gtggggggcat 24120 ggaggagggt ccgtgatacc cctgggccca gggctggctc agtcctcagc ctgtgcgtct 24180 ttatgactca agcggggggc ctctggctcc cccaaacaca cccccaggat atccagggag 24240 accctgagag ggcgaatccc gcgtcccctg gggctgcatc ccccgtccca cccctggggc 24300 cggcacagcg gggcacacgg cttcatcacc aagcccatgt cccagggact catgtgtgtg 24360 acacaaaatg aaattcctcc cgcattagtg taaaacagaa cacagatgcc cagtgggagg 24420 ggctggcatc ctccgcgtca ggaagccacc aaccgtttgg gcttcaggtt gtaattccca 24480 atgcgctccc tccactgttc cgtttccatc atccggcgcg tccagctgaa atggaatggg 24540 tgtaagtgtg tttatgcctc gtctcagtct tcccagctgc tatggaaaag caccacagac 24600 ccggcagcct cagcaacaga gatttatttc tcagttctgg aggctggaag cccaggatca 24660 aggcgccggc ggaccaggct cctggtgaga gcatctctca ggcttgcacg tggcgtcttc 24720 tcactgcgcc cacggggcag agaatgcagg ctctctgctc tcttcctgtg gggcactgct 24780 cccatcccga ggccccactc tcatgaactc gtccaagcct actcacctcc tgaaggccct 24840 gtctctaaat accatcccat cagcggtggg ggcttcaaca agggaatctg ggggtgcaat 24900 tcagcctgga gcaggcttgg agggaaagaa ggggacgctg caaaagatgt cgtgggaaat 24960 cctccggggg attaagttgc cccttcattt caaattcctt aaacttcaag ggcatctgcc 25020 aggtccctcg ggagagcctc ctgcatgcag ctttcctctc ctctccagcg ctcatcacaa 25080 cagcggccac tgtgtgagtg aaggctgagg ccacactgcc tgtgcctccc cagcagtcag 25140 tgacgggcgt ggctctccga ggcagtgaac ttgcagagtg caggaagctg ggggctgcag 25200 agctcgcctg cagggcagca ccccagaggc ctggcagggt gggtgagctg tcccgtgacc 25260 cgtcacccct ccaccaggtc ccaaaagcaa aagcgttggt ggggtgtcag gagttccagc 25320 tgtacctaga aattgtcctg catcctgttc caggagatat cgtccatctt ggggtcaaca 25380 tggaatgcca cctgcatgaa cagggccggc gccggcatcc actgccattg cccgaggctt 25440 ggctccacag ggtggcaggc agggaggaga ggctgctgct ccctggcagg aagttcttgt 25500 gcaccacgtg agcgtgtggc tcccgaaggg gcattttgtg cctgtgcgac cgacagctgt 25560 gcccacgcgt ctgctgcatg gccatgtcta cacggggcct gctgcctcca gagggaccct 25620 ggggcttggg gggcctcaga gccctgtcag taggaagggg gccctggctc tcctggtggg 25680 tgtccggagc atctagagct gtcccgggaa gtgccgtgtc ccagggacct tgttactgat 25740 gattctgcca gtctggcaag tccatcaaag gcatcaccgc cttcagtgcc aggccacccc 25800 tcggggcttg caggcctggt gtccggctgc ccccagccca gcacaggtac ctcatgtcct 25860 tgaacacccc ctcctccatc cagtctgagc gccatggctc agcgcagccc cgtcccagac 25920 cagtgtccgt tcccctgagg gtgctgtggg ctggggaggc ccaggtatcc ctgccacctt 25980 cactctgagc ccgtctcttc ctctccaggt tttcataaga ggccccggga agctccatgc 26040 cctcctccca gcactcctgc tttcccctct gaatttttat ccatcatggg cccctgaata 26100 agagctgact gtgggatcca ggctcagagg ctcgagaggc acagggggag ggcaccaagg 26160 gccttgcagt ccaggccagc ctcagggtca ggcctccagg ggcctcaact ttgtgtcctc 26220 cccatggggt gcttttcatc cccggaggcc aggctggggg tggctcaggg ggcaccatct 26280 gcacaggtgg gggcagccgt gggcgggtag agacagcggg ccccgcgtgc actcccatcc 26340 tgagccccct gagcctcaaa caagagtgaa ggcagtgccc agggaagcac aggccaacgg 26400 gggcaggcac agccttgtgg tggccagaga accaggtcct cacctgcagg atccaggcag 26460 gccagtggtc ggcgaggggc gtggccagtc tgcctgttcc ttcctccacg tatgcaggca 26520 ttcattcatt cagtcatgca acagaggtca agttgagtgt ctgctgtagg caccagattc 26580 agcaaataca aatacaggat gcctggttaa atatgactgt cagataaaca gtgaatcatt 26640 tcccagtgga agtgtatcct atccaatatc ggggacgtgc ttatacttaa gacaattatt 26700 ttccatctga cattgaaacc tcaccaggtg tgtcatgtat ttcattggga tccctagctc 26760 cggctgggtc ggctgggctg ccccgagagg cccaacatga aggccccggc cacccacctg 26820 gattggagct tcctccgccc aggcagagcc tgggctcctg caggcacaga tgggcccccc 26880 accactggct tcgaggatga ccctgaacct tccctctagc agacaacaga tctgacaggg 26940 tcttcccccc atgagagggg gtgcccctgg gctcccccat gtgatcctga gggtaatctt 27000 ggtggaagca gcgctggggc ctgtccctgc cccacccagg aggcaactgc gtgggggggc 27060 gtgtggtgga cacatgacaa acccagccca ggatcccttg gtggctcaat ggcccaaccg 27120 cctccctgca cagacaggaa aacggagtcc tcagaagggc ggggcctgtc gagggccaca 27180 cagctgccgg gggggacctc agaaggaggg gtctgtggag agtactccag gtcccctata 27240 gtgtttgaac agggccttcg aaagattcct gtcctcccag aaccccagaa tgtggcttat 27300 gtagaaacac ggtctttgca gatgtgatta gttgaggatc tcaaggtgag gccattctgg 27360 accgaggggc tcagatccag tgacttatac gaagagaagg aacaaaccca gagacacaga 27420 gaagaagcca cgccgggaca gacgcagaga tcagagtgac gctaccacga gcccagggcc 27480 accaggagct ggagacggcg gaggacccgc tacgcttgcg ggggagggtg gacctgccaa 27540 caccaggatt ttgcattctg gtctccagaa cagagagaag agaccgctgt agttttgggc 27600 actcagtttg tggtattgag ccccaggaca cccatgcaca aatgagaggg tgcaggggtc 27660 actctgggac agcaccaaag ccgggggggc cccaggggcc actaaggagg ttccccacgtg 27720 gagctgtggc tgcccttgct gggtttggga ccctcagccg ggtccaggcg gacagagtct 27780 gtttccagca cagccccgtc cttttgctgg gcggtttgcc tgggcgtgtc ctaagttgat 27840 tgaatatatg ctggaaagca gaaatgccgg aaaagaggcc ccctcccacc cgccctggga 27900 gcccaggtct ggcaggagga accacctggg cgataggggt ctggggagga agaggggttg 27960 gtgggcagca gcctccccgg ccaccaccca ggagccatgg ctgtgggggc tcggagtggc 28020 caccccaccc aggaggaggg gcctgtcagg gcaagagacc cccacatcct cccctgacct 28080 tgatccacag aagggccggc aaaggactgg ggagaggcct gcagtcgtgg gggcaggggg 28140 atgaggggag gggacaggag gagccagggc gctgtctggg ctgggggctg ggctggggca 28200 ggggcagctg agggcctgcg gtggatgctc ccagcccctc tccacagcac tacgtggcac 28260 agggccagca gccccccgggg gagactcccg gcctgcaggg ccctctgggg cctccctggg 28320 tctcggatcc cttccaggga cctggatgag gccgtacccc cagggacaga agtgcccctg 28380 ggagcaaagc cagcccagtc ttgggtggcc tgagctcaga gctccccctg gcttctgtgg 28440 ctcgccatgt ggccagggcc gcatctttac ccccaccccg ttccaagcct cagtgggtcc 28500 cttggtaggt agaacctgtt gggagggtaa agcgaggcac cccaggtaag ccaagttctg 28560 ctacggacgg ggccccttgg agacccagat cagactctgc caaggcctcg ccctactccc 28620 gcccccaacc tgatgattag ctaattaatt ctgtctctcc ctccctctat ctctccttcc 28680 ctctctctct ctctacctct ctccctccct ctctctctct cactctctac ctttccctcc 28740 ctctctccct ccctctctcc ctctctctct cttcctctct ctccgtcttt cctattctct 28800 ctctctctcc ctctctttcc cattctctca ctctctccct gtctctctcc ctccctctcc 28860 ctctctcttt cccattctct ctctccctct ctccctcttt cccattctct ctctctccct 28920 ctctctctct ccctccctct ccctctcttt cccattctcc ctctccctct ctttcccatt 28980 ctctctctcc ctctctccct ctctctttcc cattctccct ctccctctct ttcccattct 29040 ctctctctct ccctctctcc ctctgtttcc cattctctct ctccctctct ctccctcttt 29100 ccccttctct cccctctccc tccctccctc tctccctccc tcttcctctc tccccccctc 29160 cctcccccct ttctccctct ctctctcttt cccattctct ctctccctct ccctctctct 29220 ctctctttcc cattctctct ccccctctct ctctccctct ttctccctct ctttcccatt 29280 ctctctctct ccctgtccct ctctttccca ttctctctct ccccctctct ccctccctct 29340 ttctccctct ttcccattct ctctctctct ccctctccct ctctctccct ctctctccca 29400 ctctctccct ctcttttccc ttctctcccc cctctccctc tctctctctc tctctttctc 29460 tctctccctc tctctctgtc agtttcccca ctctctgcag ggtcccctcc acagtgatta 29520 gtcaaggccc agcccgaggg gcctgggaac ggggaggggg agcccagccg tgtgtcacct 29580 ttgggagagg aggacctctt ccatgcctgg tggtactgtt gtgcctttga agggaggtgt 29640 ggcaccaggc cgggtggtgt ccgccatgcc aaaggccact ctgcatcccg gcccccagcc 29700 cctgggtact gctcctccag cccccactcg ctggcctgga ttctccggac agaggtgggg 29760 cccacagggg agcaaaggac catccagaga gcgtgggtct gtgccagggc ccttctcaga 29820 gcagccgaag gatgaccatc ctgactgacc gtcccaatct gcagcctggg actgggacct 29880 gctgtgcagg gctctaaaaa ggcgagtgag ggaaagatgt tgcagtgggg aggccatcct 29940 ggcccaaaac gcagtcacaa agtccttaaa agagggcggc aaagagggtt aaaatggcaa 30000 tatttgtgtt atgcacattt actacaaaaa caagcttgcc ttaagaaaac tcaaaaaaga 30060 aaaagattaa caggcagaag gagatggccg tgtgaaggcg ggggcagaga ctggagtgat 30120 gtggccaccg ccgaggggtg cctggagtcc ccagaagttg gaagaggcag gaaggaccct 30180 ccctagggcc tccaaggaag cgtagccttg tgacactgga cttcagccca gggacactga 30240 tgtccaactc tggcctccag aactgttgct tcaagccccc cgctgtggta ctttgttatg 30300 gcagccccag gacaccccga caccaggaaa tcgcataatt gtttggaggg agaacatcgg 30360 ggcagattca cctggtttct atgtggggca gaaaagagcc agcggccaag ccacccgcag 30420 gcccctcctt gggaagtgag acccccacag cctcactgcg gatgtaacag ccacccacgg 30480 cctgcctggg aaaagcccag atttcaggag gccctgatta ggtctcccaa gactcacgcc 30540 ctgttccggg ggaacaggaa gtgggaggca tctccccaga actcagggag gccaaggcca 30600 tgcccacgga ggggcagaga gccgggggcc ggagagtgag ggccgcagcc acgggctggg 30660 aagggggagag ggccgggcag gggtcctggg agaggggcag cccaagccca gcttggagag 30720 acatctcccc agcggccccg gcatgtgctc agcagctggt gagctcaatc caggagtgtt 30780 ttgccgggtc tggttatggt gattcacaaa ccccttttta atctggaaca gctcccacca 30840 ggcgggtccc ccaggatttc ccaccctacc cccgggattg tgaatctgag acatcacacc 30900 acgattgtca cgtgacatgg tgttcgggat tgaactgtgt cccccaagat ttatatatca 30960 aagccccaac ccatggtacc ttagactatg actgtatttg gaaattggtt ctttagaggt 31020 aattaaggtg aaatgaggtc attcagttgg gccctaattc aataggacta aggcccctct 31080 ttatacaaag gaggaatggg gagacaggta tacacgggag atataattaa gttcgctgag 31140 cagttgaatt tgaattaatc aaagggcgat tatccgagtg ggctgcgtct actcacacgt 31200 gccctctgaa agcagcgttt cctctggctg gcagtggaag aggtgaagtg actggaggca 31260 gcagggaact gaacacatct gtacttgctt tagagatgag ggcatatgcc aaggaaggag 31320 gtggccctgg ggagctgaga gcaaccccct gccagcggcc agcaagaaag ggggtcctct 31380 gtcccactgt gcaggagggg attccgcaga tggcgggaat gagcctggga gcagattcct 31440 gctgggctcc agatgcgggc ccagccctgc ggatgcctcc gtctcagcct catgggaccc 31500 tctgcagaaa accaagctca gctgtgcgca gacttctacc ctacagaact gagaagtgat 31560 aagtgggtgc tgctgtgagc ttccaggctg gtggtggttc gttacgcaac agaggtagca 31620 cgtacaccag gcctctcgtc ctgcagaagt ttccaccgtc tgcacgtgtc cggtggcctc 31680 tctgtgggtg gttcagcttg ttcttctgcc tccagtattt tttgcaaagt ggaagttggg 31740 tctgcaggcc tgctggacag agcttacttg atcgaggctt gaaaatgttg cacgtgccct 31800 tggtgtctgc gtgtggcctc aggtcctggt tgcccgtgtc aaagatggcc tgatggacct 31860 gctggggcca gcccaacccc accactgggc aggtacttcc ccctggtcac ctcaaggtgg 31920 cctgtggctt tacgagcacc cagtgttccc tctgtggctc ttggccccct ctgaaggccc 31980 ttcccaagcc tgtccttcca ctgggacctg ggaggtgcag gctgcctttt tctcttcctc 32040 cctccatcag cgttacccac attctcctct gcactgtgct gatccttcat ccatgggagc 32100 tgtgcacccc caaatataat tcctgctgga aacaccctcg accctttctc tttaatgaca 32160 gattttcaca gtaaggcagt gttgaattgc agcctctagt ggcgacaaca aggaaagggg 32220 ttccctggac tcccccttcg gagcatcagg tgtggaccca tggagttccg tggacctgcc 32280 gtgtgtggtg ggccaaataa tgctcccctg aagatgtcca tgtcctgatc ccagaaaccc 32340 atgactatgt aaccatgcgt ggcgaggggg accacacgtg gtgaggggga ttagcagata 32400 tgattaagtg gagggccttg aagatgggaa attatcgtgg atgatctggg tgagccaaga 32460 tcatcacaga ttcctagggg agggaggcag aggttcagag tcgctggaga aggagatgag 32520 caggggaagc aaggactgga gcgatgggag gaggggccca gccggggagg gtggtggtca 32580 ccggaagctg gaagaggcaa ggaaatggac ccctccctgg gactccagaa ggagccagcc 32640 ctgccggcac ttcaggcttg ggatttcgga cctccgggat ggtgtgctta aaacacttgt 32700 gttggccggg tacggtggct cacacctgaa atctcagcac tttgggaggc caaggcaggc 32760 agatctctcg agctcaggag ttccagacca gcctgggcaa catggcaaaa ccctgtctct 32820 acaaaaaata caaaacttag ccgagcatgg tggtgcatgc ctgtagtccc agctacttgg 32880 gaagctgagg caggaggatc acttgagccc aggaggtcca ggctgcagtg agcgatgttc 32940 atgccactgc actccagcct gggcaacaaa gtgagatccc gtctcaaggt aaaaaaaaaa 33000 aaaaaaaaaa aaagtgtggt ttagcaattg aatttgtggt catttgtaac cacagcagca 33060 ggaagcccac acgccatgtt tgaatcattg tcccctctga gatccccaccg cctccacttt 33120 ggccaatggg agcccttccc actggcttcc gtacccttgg acatgacccc attcctcttt 33180 gcaacttcct tgttctctag caaaactaga ttttccacac tctcgaacct tccctgccct 33240 gagtcagtca ttctctgggg atgggtcttt cagcgcggct cgcgttagaa tctcagtcgc 33300 ctggcgtgtc ttcattttgg atcacagtgt cctgcatacc cacaatgtta ctaattttat 33360 cattgttttt actccaccaa ggtttaaatg cttacctgtt ctataaccat attttgtgta 33420 attctctaac gctctgtagc cacctcagtg ggcttcccgc tgcccaccca ccctttcata 33480 cggcttcttc acgctggaat tctttctttg gcatttcttt tagcagcttc atttcatctt 33540 tgaggtggct gtggttgttt ttctcccaac aagggcgtgt gcatttgtgc cgcgttctct 33600 cacgttcctt tgcgttggag gacatcgccc ctgtgtctct agactcgagt gacattttgg 33660 ctgggtataa tagtcctaga cctcattttt tcccattaga acttgatcag catgggaccg 33720 tcatcctctg gtgcttagtt cactgcagaa aatctgcagc cagctcactt cacccccttc 33780 gtagtgactc actggttctg tcttgtgcac ctgcagaatc ttctttaccc tcagctgagg 33840 aggtggagta ggagccatat ctggatggaa tgcatcctgt gtcttgtttt cctgggactc 33900 cgtgcacagt tctttctttg cttcatcatc acatatctaa atacttttca aatatgcgtg 33960 tatatatata tatatata tatatata tagagagaga gagagaga gagagagaga gagagagaga gggagtctca ctctgtcatc caggctggag tgcagtggca 34080 tgatatttca gctcactgca acctccgcct cccaggttcg agattctcct gcctcagcct 34140 ccccagtagc tgggattaca ggtgcccacc accacgtcca gctaattttt gtatttttag 34200 tagagatggg gtttcacctt gttggttagg ctggtgttga actcctgacc tcaggtgatc 34260 tgcccgcctc agcctcccaa agtgctggga ttacaggcat gagccaccgc aactggcttc 34320 aaatatattt taaataccaa aaactagttg aggcttctac ccaggggtac aagcaatcct 34380 ccagtggaag tgtcctcacc cttcctccgg tgcctggatc ttgttgtgcc tttgctgtgc 34440 tggtcagagc cagccatctg tgtctataat ccaatttcag ccatgcctct cctgttcctc 34500 ctggcttggg ctcattgagt cataactgta tggcgtgtgg gctctccgct tgcttctgga 34560 gttctgtggt ctccccctct gccactggct gctgagatga acaggctcat ctcatcttcg 34620 agtgtggctt ccattgcacc ttgtccttat caagttgaca cagtgcccaa attcctcctg 34680 gggaacttcc ttcttctctg ggttttgttt tattgttggc cgggttcttt gtctgctgaa 34740 gtccaaccta tctctctctc tctctctctc tctctcattc tctctctctt ctcttttttc 34800 tcccttcctt cctttccttc ttccttccct ccttcctggg gctccatgcc cttctcccac 34860 tgggggcaat caagaggtct cacctcagtc caagggtcag ccctggtgtc tccccagcca 34920 gacagtgacc aaagtcagga cacaccccct ggttgcctcc tgatgagggc taagggtgag 34980 gattccggca ctcccagttt ggactcagaa gacaggagca gtgtggggag cagcaccgcc 35040 tgtacctcct ctgtgactcc cctggacacc ctccaggagg tctgtgatgc tgacctgccc 35100 tctccttgtc ggctctgagt cattcatctc cagttcttac tatgcttgtt tgttgtcctg 35160 ggttagtgca gccctcatac ctgcccccgc acctgccccc acacctgcct tcacacctgc 35220 ccccacaact gccccccata cctgcccctg cacctgcccc acaactgccc tcacacctgc 35280 cccccacacc tgcccctgca cctcccccca cacctgccag cacacctgcc cccacacctg 35340 ccctcacacc tgcccccaca cctgccttca tacctgcccc cacaactgcc ccccatacct 35400 gcccctgcac ctgccccaac tgccctcaca cctgccccca cacccgcccc cacacccgcc 35460 cccacacctg cccccacacc cgccctcaca cccgccccca cacctgcctc acacctgccc 35520 ccacaactgc cccccatacc tgcccctgca cctgccccca cacctgccct cacacctgcc 35580 cccacacctg cctttgcacc tgcccccaca cctgccctca catctgtaaa tgtcacactg 35640 cccagccctg cactcctctc ccacttggcc agtttcaggc tgtaccactc caccgaggtg 35700 accccagcta gtttggggct tcagatccca ctgctgagcc ggagacccag atgggtctca 35760 gactgacagt ctcagactgg cagcccccca tagcaccagg cgtgggtgcc cacccacgag 35820 atgtcacctg gcaggcactt tgagaatgtc cagaatgggt gtcataatcc accccccgcc 35880 tgctcctttt gtcttcccca ccttggggtg tcaccacctg cctgttccct ccccccagcc 35940 tgggcgctgt ccctcccccc tagtccttca ggaagtctag ccagtgccac cttcaaaaca 36000 caccttggat ccacctggtc ccctgtcctc tgtccagccc gcagtcccac tcagctcgcg 36060 gtaggcaaag cgaggcccca ccctctctgc agggctcttg gagacacgtt tgaaccacag 36120 cgtctgtgtg ctctctaaaa gggcagttgt tattttttcc tgagtttcca ggatgtctgc 36180 ccctgtgtag ccatagggtc gagcctctcc aggctccatg ggagcagaaa gtgctgggga 36240 cacctcaagg ctcacgtggc tctgtggacc ccgagcctgg ggccccagcc caccttcccc 36300 tccgtgcctg gctccagcca tgggccctgc acccgtcctg gtgccctgag gccaggaaag 36360 ggggcttctg ggactgctgc tcgatgccga aggtattgtc cttcccacat gggaatcatc 36420 tcactggact ttctgtgaca aacatagaca gtcatttcaa aataaatcaa acttcagacg 36480 tggtacagca gcaagttgcg aagatcctcc tcccctcccc gcaccccagg cggcacctgc 36540 tgcagccggc tgtgggcact ccatggacaa cacggcacag atgttctctt gtcacataac 36600 tctcatcctg tacttcaaag gccacgagta agtgaagacc cactgcactc tcgaaaagca 36660 ggaacggaaa aagtcacagc actgcatcat ggagcagccg ccccgggtgg gcgcgcgcgt 36720 ttgcctcctg cgtgaggctt cctccagcac tgcggtgggc tgtgggttcg ttcccaggga 36780 atgtgagcga gccgcatccg cagcccaggc accctccctc ccagcttcct ccccgcccca 36840 gggtgaccat gtatgggcag ccctgatgtc catcggccct ttgtgcagtc atggcgcggt 36900 gaagggccct gcaggcggcg cccaggggtg gtgcggggct ccgcctggtc tgtttactca 36960 cagcacagca tggggctcac tcagcagcac gcccaggaga agagcccagc ctcattcttt 37020 acagccgttc tggggcactc cacaggaggg ttgaaggggg cttccatctg ctggtgctcc 37080 ccaacaccag gggctggcag agggtactcg tgctttgcag gtacaaacag cgctctcccc 37140 tggggtagac ccgagccacg acaggcagcc agggcgacat gcataggagc gtgtgctcag 37200 accacacaca gtggcttttc aggggatttt ccttactcag ccacatcggg gagggcgcta 37260 gggcaggtat cgggagcgcc agtgagttgg tcattttctg agcatgatgg cggctcagcg 37320 tttggacccc cagagggagc agggccctgt gcctcagcct ccctcgagtg gtccagccct 37380 ccctcagcat gggtgctgaa gaaatggaag cctgtgctgc ctgtcaggga cctgccgctg 37440 gagttttacc cccaccccat ccgcgttggc cacccaggcc cctgtggcac gggtgcatgg 37500 aggcctagtg aggtcagaaa ccgtccagcc aagggtgggg ggattcaggg tgggggaaca 37560 ggcagccggc tccgggaggg cttctggtgt gagtttgggg cgggccggcc cactccctgg 37620 agttggtgct gtcagggggt cctaggccca cctgcctccc acaggcctct gtactcactg 37680 ggccctggct gttggttggg ggaagaaata gagacagatc cctggcttgc aaggactcca 37740 ggtctggggt cagagcgtgg acaagtccgg agggctctgc cacccggcac tgctgaggac 37800 aggggcgcat ctgacagcct cctgcctcta ccgagctggc ttcggggcag ctgggcctcc 37860 cggtgccaat accccccggc tgttacctgc ctgtcacctg ggcgagtcac ctggagccgc 37920 gtctgtgaca tggaagggaa cggttacaaa agccacatca tgtgagatgt gcgggcccag 37980 ccaggcatct ggggcagacc agcgctgcac acacacaggt gggatctgtg cccggtgccc 38040 agcctggcat acaggcacca tcccggagtg cccccatggg ctgtgccctg acagctttgg 38100 aggtaggaat tggggggtga ggaccctggt gaggacaggc aaactcagcc atcacccccc 38160 tggccagggt actacaccca ccccacacca gggctggggg ctaggggtgg gcacagcttg 38220 ggcaggccat cctgagcgcc aggcctggtc cgcaggccgg ctggagggcc ctgccctgcc 38280 aagcgggact ccggctcctc tccagcatct gccgcccggg gtgggcgccc agggccacca 38340 gccctcgcgg ctcctcccct ccccccgtgc gcgactgtca ttgttaccat tgcttggctt 38400 ctgccaaagc agccgcaggg ccaccgggtg cttgaacctt ctccatgggg cgtcctggcg 38460 gtggtttgag ccgggcagtc ctccccgccc tccccagccc cccagccccg gcacccggcc 38520 gttccactgc gcggcggcgt ggggagggcg cggcgcgagc tgagatggtt ccgcccggcg 38580 ccgcccccgc tgcccgccgc ccgccgcccg ccgcgccgag cgctcccgca ggatggcgcg 38640 ggccaagctg ccgcgctcgc cgtccgaggg caaggcgggc ccggggggcg ccccagccgg 38700 cgccgcagcc cccgaggagc ctcacgggct cagcccgctg ctgccggccc gcggcggggg 38760 ctccgtgggc agcgacgtgg gccagaggta ggggcgcgcg ggcctgggac cccgcttgtc 38820 aaatcgcgct tgcatcctgc tcgggctgcg ctggctgggc tgcacctgcg ttgcctgcag 38880 cccggggaag gggggaggcc agggtctccc ctcctaagcc caccacagcg ccctgcttcc 38940 tgccgtgtct ccagcctttg agagcctgcg ggacccccca ctccccccac gtaggggctg 39000 aacacggcgg ggctgcaggt gagactgcag gggagggagg aagtggaccc agctctgtgc 39060 caggcactgg gggcccctgc ccgagccctg tcccacagga gccccgatct tgttggtgcc 39120 agcgccactt tgggggagac agggccggca tccgtgtccc caccccagag gtgagtgagg 39180 ccgaagcctg cacagcaggt cagggctggg acacagggct caggctgcct ggggagccct 39240 gctgtggggt atgcttgggc tggtgtctgg tgcttgtggc aggaggggtg caggtggccg 39300 tcctctgggg atggttgggc aggtggagca gcgcctaccc ctccttggct cttccgcaag 39360 ctcagggtgg gacacagcac ccccatttca cggatgagga caccaaggcc tcatctgcag 39420 cagcaaattc ctagccagca cctttcccgt gccaggagcc gttctagatg ctgcggggga 39480 aatgaggatg aatcagacct ggcctggtgt gggcacatgt cgtgggcacg gaacctgttc 39540 ctgggagaga gaggtgcagg ccaggccggg acagaagagc cggggactcc tggggtgctg 39600 gtccttccgg gacaagcatg gggagatggg caggggcctt ccaggtagcg gaagcagtga 39660 gggctgaagt ttcatcaggg ctggggggca gggctggcag agcagggcct ggcagatggc 39720 agggccaagg gtgcccagga gcctctccct tacccctcct acctggctgt gggctgttgg 39780 gcccctcccg gcacccccat ttctagctct tcacagcagc cctggggggg cactgcccag 39840 cttagtccca tttgcagaag aggcggttga ggctaaggtc aagcacctgg ctgcagcctc 39900 ctgcagctaa tgggcagcct ccgccaggga ggcgagcact ggccaaggcc ctggggacca 39960 cagtcccctc cccctcctct tcctggatgc tggcgtgggg ggaaggggga gggcagtgat 40020 cctggaagcc ctgctacagc cagccctcaa ggggcaggtt ccttgcccca tccctgttcc 40080 tgcagggccc atagggatag caggttctgc ccaggctgcg tctgagcccg cagtgcagtg 40140 cagcatggga gctgtagcct aggcccacct cctccaggaa gccctcccgc atgttcatcc 40200 cagccctgtg ggctatgcac tgtgctgacg gtttcacatg ggtggcctcg ctcatccccc 40260 ggcagcccct gaggtgcaga gtccttatag cctccttttg cagagcagag gtaatggagc 40320 tgctgcccag ctgggctgag cagcccctgg gcctggagca ttcatacaac agggctcgcg 40380 ctgagatgag tagggcaggc tcctgagcag aggacttggt aggtttgttc ttctggagtg 40440 tggatctcac ggaaaacaca ggcgaggcca gagccgagag gcaggtgtgg tctgccccag 40500 ggagctgggg gtcgcagtgc ccgcagctgc ctcatcctgc aggcctgagc tgccttcatg 40560 ggccagccag ggtcccggct ccctcagccc tctcagactc tgcccgtctc attgttgaga 40620 agacagtgaa gcagaggaga ggtctccact gcccaccagg gactgagcca caggaggcgt 40680 tgtcggggga gggcacttgc tcctggtgcc cctgcccaga gctcccctaa caccctgtgc 40740 ccacttatgg gtgctgcagg ctggcctctg tccctcctcc cacacagtcc agctcccctg 40800 accctgagct ccggggtctc ctccttcctt ctcactcccc tgtgtgaggc tggggaggga 40860 ttgggagctg attagacagc gtggcttcag tggtggggtc aggagaccat cactgcaaag 40920 cttttgagta aaagtgccca atggggggac agggcctctc agtgagaccc cgctgcatca 40980 ggaggccctg agcccctctg tgtccctacc acccctggac ctaggcggcc ttgcccctcc 41040 cagctggggt ctcccagcct catgcctgac ttaaggcacc aacacagccc cctccccaca 41100 tcctctccgg ggccgttccc ccagccccat cctactcttc tggccctagc actgcactgg 41160 gcagggggcc catgctgagg agctcacctg gactgcgtgt tctgccccca caccatccct 41220 gagggaggtg gggcacctct ctttgacccc agggagcaag cctgaggccc ccacacagcc 41280 tgaggtctag cgtggtccag ttctcctgcc actgtgccca gcaccccagt gtctatggca 41340 gccacaggtc tgtcagtcca gctgtggcac gcagagcccc ggccccgccc caagcccctc 41400 gccctgatgt tccttggctc aggagatggt cccctgagcc ccccgacccc ggacaccctt 41460 gccaggacct ccctcccctg cagatccaga ccttcatggt tgcccctctc ctctccaaga 41520 acctggctgc tcctccatgc ccccctcacc ccgggcacac gcccggcgcc ccaccctctt 41580 catggtgttc acaccggctc ggcacacccc ttcccctggg cctgaagccc cccttggagc 41640 ttgccccaga tggcctctct cccaggaggg cccctcctga gtatggtccc gtcacccctg 41700 aggtgccccc gccctcctct ggctttgccc cgctccgggc tgcacacctt ctttccacac 41760 agtgctctgc gctctttctc ccccacccta gaatgcacct gtttgggcgg ctggtttatc 41820 cttgacccag gagcgtgcac agggagtgcc cagccgcagg ggtggggctg tgttcccagg 41880 ccctcggggg acaccaggcc ctgtctttca ggggtgtttg ctgggcccac acctcattta 41940 ttgtctcaca gtcctggagg ctggaagtct gagctcaaga tgtgggcagg gctggttcct 42000 cctgaggccc ctccccttgg ctcgtagaca ccatcttctc cctgtgtcct ctcctggccg 42060 tcccgctatg tgtgtctgtg tcctcatctc ttcttataag gacaccagtt ttgtgggatt 42120 agggcccacc ctcatggcct cactttacct taatgaccgc tttaaaggcc tcgtctccaa 42180 acatagccac gtgctgagat actgggggtc aggacttcag catgttagcc tgggggcaca 42240 aaactccgcc cgagataagg gggtgccttt gttgcgtgtg ggaacctgcc gggacctggc 42300 tgtgctctgg gcattcccca ggtttagaac agaggctccc aaactccccc aagcagggaa 42360 ccccctcttc cccaaagcat cttatgggac ttggggttgt ggggtgcaga gggacactcc 42420 actcttcccc cagtcagccc agaggggctc ctagagagcc cagagggtcc ctccctctcg 42480 aggctggcag ctgagactgc tccttatggg cacaagtcaa gtggggatgg cccctcctca 42540 cctgggctcc ttcccgaccc cagccccagg ctctgcagga cacagcaggg aagcagggct 42600 aagcccagat ccttccactg accactgctg ccctaagcag ggctgagacc ctctcctggg 42660 agggaggtga cggcttcggg tgcaggttct gttcgtgtgt tgacagcgag cctggccatg 42720 ggaggtgggt gggcccaggg atgaggccct caccacttgg tcccaacagc taagttaggg 42780 ctggcagaga tgctgagtgg cacccaggcc accaaccgct gggacaggcg agcatcaggg 42840 tcctcctgga ccaccgtggg tttggatgct gcggatagag gccgagcttc ctcagctccc 42900 ctcccctccc ctccccacccc tcaccctgca gttcacttgg cagggtttgt gcagccgaca 42960 gaccttgttt gcacagagct ccagtcctca gccaggttct gcacaggcca gcaaagcccc 43020 aggtcccttt gcccacaggc cgctgccctc cccttgggag tccctgggtg gatcctctac 43080 ccatgtgctt ggtggcccct tccaaaatca gtggggacgg ctgtcctggg cctcaggctg 43140 tgggacatct gacaggtggt ggcttcctca acactcagac aacagggcct tgggcagagt 43200 agatgggagg ccccatgcgc agctcagtag acactcagct agggctatat cgggagatgc 43260 agagggacgc ggccagggag cacctgggag agaggacaca gtgggcccca gcagggagga 43320 gcccagccag ggcctggcca cgccggacct gacccacagg ccaggcagac ccgctgccat 43380 gggctgaggc actgccaggc tcctgccagc ctctgacacg gctgttgccc tggctcagag 43440 cttcaggcag caccagggtc cagcgagagg gaagctgagc cggacaaaca cgcagaatct 43500 gccagaagct cccagcaaac ccaaagatca gccccattaa gcctggggtt ctgcctgctc 43560 cgtgtggagc tgctggcccg gccaccatgc ccagccagga cctcggccct cccaggggtg 43620 tgtccagctt ctgcctcccc cagggaccag aagctgctag ggctaggggc accaggaggg 43680 cacctgccca cccggagagc ctggcgtagg ccgatgagcg tgtgcctgtg accccaggct 43740 ggcttcctcc ttcctgcctg tgtggcctca gaagactgtg gtcctctctg aacctttgtt 43800 ttcttttctg aaaacatggt tgttttgagg attaaaagag agaggtccct ctgaagtcct 43860 ttgaggagga gctggtccag gacaggcaca tagtcagtga aggcaaagac cctcggcact 43920 cccaccctgc ccagcccccg accaggccgg ccctctggag ccctcagctc ccatcagcct 43980 ctctctccga gttccgaatc cagtgcaggt tgcaaccacc ttggtgtcag ccgcctgctg 44040 gccagtctgg gacaactggg gccaggttgc ctggggccag gctgaagggg tagcaggtgt 44100 gtggctgctg gcgtggtgga gggtggtgtg tccaggtccc ctgagaggca tcagctctga 44160 gccctggctt gtcctatcgc agggagcctt ggggcagggc tggcgggtgc ctcacccgct 44220 ggtctgggtg tagggcaggg gagtggagac aaggggacag cctcgcagac ctcggcatga 44280 ggtggagctc accgcgctcg cttctggatg ctggggacca cacatggggc ctgggctggc 44340 ttcgtgctga gcagggccag ggcgagtgcc caaagcatcg tcacctgctt gcgtggctga 44400 agggtggccc tctcctcgag tgtggttgtc acccccccat ctggcccagg cacaggaggg 44460 tgcatgcgcg gggacctcca agcgggctgt gctgctttct cgggccctga gggggccagg 44520 cttggctcag tgcccccaca tggctctgca catggactgc ctcccacagg cacctctccc 44580 gtgcccgggg gcgccaaagg tccgggcccc ccagagcctc cctgcgtgtc tgtgccccgc 44640 ctggtcccag agcccaggct ctccatctgt ctgtctactg ccttctccat ccgtccgtct 44700 atctgtctgc tgccttctcc atctgtccat ctgtctcccg cattctggtt gatgcccctc 44760 tgtgtcccca ggcttcctgt agaagatttc agcctggact cctccctgtc tcagtaagtg 44820 ctttgcaagg gaggaactgt cttggtggca gacaagggct cttagaggtg tgagagccct 44880 tgtttctggg gggtcccctc aacccagcat cccctgcagc tgggccaggg ccaccggcac 44940 ctcccagtac ccgctggtgc ctctgggtcc caggtgctgg ggctggagac aggacagtca 45000 gtgtgccccc ttggagagga gcctgaactt gggaaatggg ctccccagag gtgggtggtc 45060 cgcagcctca ggagaggcgg atggcagagc aggggccctt gtcatggtgc ctcccaggga 45120 caggcaggca ggcagctgct ggggcctggg ctctggctca gcccaccttg gctgcctgtg 45180 ccggtcgagc tcccaggagc tgggatgcgc tctcggaggc tgtgccactc cccactgagc 45240 cgccggggct ctgccggtgg tgcttcctga cttcagctaa gatgtaggtc aaatggaaga 45300 ggctttgagg ccagggcagc caggccctgc gcactcctgg gaagcccccc gctgccatcc 45360 accttcagcg cggtctccag gaggggcccc aggcttactg ttccatgcac ggcaccagca 45420 gcagaaacca ccgagcactc agcactcacg gctgttgagc atccaggggc tgcccggcac 45480 ccatggtggg acctattatt atcccaaaag agtcctggag gctgggaggc cagtggccac 45540 caccggacct ctatcttccc agcctggggc cccatggtgc agagggtgac gggtgtgaga 45600 tagaagccgt gcccaccacc cagggttctc ctggccccac cccaggctcc cgaggagtcg 45660 ggtctcagac ctgtggagga aatggatgcg tctgcagccg aggctatagt gtgtgccgcc 45720 gtggcacggt ctggacacag ccgatgttcc tggacctttg gaggcccagc tggactcacc 45780 cttcagccct gagccagcct cacctgggcc cctggccaag ctatgggggg gccccagagg 45840 cccaagggtg tcaaaacagg gaccccaggg ggacggagac atgtgtgtgc cctttctggg 45900 cccttgggcg tatcagatgc tctgtccagg ctcagaatag ctggccccag ggttggcagt 45960 gggcctgaag cctgcccttt cttcctgcct gcctgcctgg tgctgggggc agaggcctgc 46020 gtggagctcc caggcacctg cctaagagcc agccggcacc cagccactgc cagagagagg 46080 cagctcggac ctcggcccca tgtgagtgca gggctatggt gggccccgag gcgtgtgcct 46140 gacagcctgg agctggtgtg gagcttcccg gcatggccat ctgtgtatga ctacctgcca 46200 ggaatccctg gaaggccagt cccccagcct gcagctggcc tgccggtcag cagggagaac 46260 tgttgccggc ctctgccgac cccatttgtc acagggcggc cggcacttgc ctcagagggt 46320 cccgtcttgg tgtgggggtg ggcaccatga gagccccttt gcagcacaag ggcctcctca 46380 ggcagagcag tggcgtgagc ccctgggcac aggcaggcag tgggcatggg tacacgcggg 46440 gcccaggcct ggctcaacac cagccttgca ggactggggc agagccgcca cctggggaca 46500 gactcccctg ctgccgctac agggagcccc aaggacccag gcctggcact gcctctgacc 46560 tgctgagtga ctggggcaag cgtgggcctc ggggagcctc ggggggctac agcgggcttc 46620 agccgtgtag ggacggggct ggccaggagc tgcctgtcct cacggtgcca gggacaagtt 46680 gttcgccatg ggccagcgcc gctgacggct ctcccagggc cagggccagg gccagggttt 46740 ggcctgtgga ttcctcaggg accaaggcct caccccaggg ggtacacaag ggactgtctg 46800 aggctccctg ctgtgtctgg gaccccctgg ccaggcctgc ccgcacatgc ccatgagtct 46860 caccggccct gcgtcttgct cctgggctgt aggccgtggg cagtggcggt ccctggtgtg 46920 ccccgtcctc cccaccagcc gaaatgcaga ctggcagagg tgagacgggc ccggccccct 46980 gtggcgagtg tgtggctgcg ccctgagccc gcctcccagg gtgggggtcg ggacccgtgg 47040 ccggggatcc gggaatgcag cacccgctgc cgggtgtgga ctctgggaat ggcgatgttc 47100 ccagacggat gccgccatga gcgctcactt gctgtttgcc agataaacaa atgagtgaac 47160 tgatgagtgg atgagaatgg acacaggaag tagattcttc tgccccgtcc ttgcctattg 47220 tcctgggagc ctgcgttcac aggcaggttc ttcctagccc tgtgggcggc tccccacggg 47280 agttctcggt catctcccac ctctcagggc gttccaccga gcccacgccc agctcctggg 47340 agcaacttgc catgagcggg tcccctgctt tcccaccggc cgggccctga caggaagcgg 47400 agagtgtggc cccacccggg gtcccgcctc tgcccgtggt ccacacctgt ggcttcatag 47460 cctgggagcc acggtgagtc gaaggcctgc gctgtctctt ttggctgacg tgggtcctga 47520 tggtttgagc agacgggtgc tggcccccag atgagcaccg gggcagcctc tcaatggagc 47580 ctgtgagcaa gggcgtcgtc ccaagagaag cctgggacac agaggccatt gtttctatct 47640 cagcacagac agagctcctc cacctgtctg ctgtcctcgg gacacgccgg gagttggtcc 47700 ctgtcctggt tcccattccc cagggaggag gcccaggcgc tggcaggtgg aggggaacag 47760 ccgggcagag gagcggcagg gcccgtgtag cctcacaggg ctcactgggt ctcagccctg 47820 ggcctctggc tgccgggccg ggagcatgct gtgactctga ggagctagcg gagccctcca 47880 ggctaccagt gtccatgaac ctctgccgca gcaaggaggc ttgggccact ctggcaggaa 47940 ccaccaggcg ggtctacccc agccgggtcg gcctagagct gaccccagcc aggcctctgc 48000 agccacaggc tccctcccca ggtgccgctg cgtgactcgt gaagacagat cgcaccagtc 48060 acctgaaata cactgcaggg gaaaatggat cgttttcatc tcctttttgt ggtggtgctc 48120 ggagaagtgg gcggccacag ttcattaaaa attaaaagca gaggaggctt cattaatgtc 48180 tctggcatcg caggctccag tttctcaggg agtctgccag gccccagcgt ttctctgcct 48240 ccacgtggag ggtgccatct gtgcaggtgg gcactccccg ctgagctccg tgggggctac 48300 ccagattggg gcccacagcc cctcggtgag gggaccaggg tctggctggg ctctctccct 48360 aaggggggct cagtgctctt gtttctgggg tgccaggagg aggtcaaggg gcctcaaaga 48420 gaagctgctg ggggcgcgac tagtcccaga ccagcagccc tcgaccccac ggtgtctggg 48480 gaggaacttg gctgtccgga agccagtgag gtcctggcaa tgggcagggt tgcatctctc 48540 tgtttcctgg ctgtggaggc caaggggagc ccagggggac gcattggctt cgtggtcttg 48600 ccaggcagct gcagaggccc aaggcccaga ggtccagctg caccaggtcc acggggaggt 48660 aaagggagga gcaggagctc cttggaggcc tatgaccgat ggagggttgg gggcgtggcc 48720 ggagctggct ggggagatgg agctggctgg gtgttgcctt ggagtggagt gtggggcgat 48780 ggtcagggcg gagctgggca cccccgccta ggaggagtgg ccaggcagga gcccaaggcc 48840 cagagggagg tcagagggaa gaaacatcct gagggcagag ctgcaggacc tgctgatggc 48900 tctggtctag gggaggggag ggtacaggag cctgaggttg gtgggggatg gttggcctgg 48960 tgccatcagg aatggagaat tctgcctcgg ggagggggag ccggtggatg ccagagggta 49020 gagtggggct ggacggctgc cagcagagcc agttgggaag tcacccctgc gtggcactta 49080 attcccgggc tgggtgggag agaggcacct gtggcaagcc ctggggtccc ccaaggagaa 49140 cggagcggag gggagaacaa cagagctcgg ggaggccgtg ctgagaggcc cagggagtag 49200 aggagattct ggggtctggt caccgtgaag ggcatggtga ggctccctgc cggagaggag 49260 agggtgggag gcagtaggag caagtgaggt gagcagaccc cccgcgttga ggcttttgcc 49320 atggagggcg ggacagtggt agggaggcgg ggagggtggg ttcctaagct ccatgctttt 49380 agggcccggt ggtccctggg taccgccggc agtgagggga ggagggcctt gggagaccct 49440 gggctcagcc cccgggggca gctcccgcct cagccctgcc tgcccccctg acatggccag 49500 accaggccca gcgcagcctg gacctccagc atcctgtctg agcgaaagac atccattcag 49560 agagaaagac ggcggacaga ccccccaaag agacacttat gcagggaggg gcctccccag 49620 ccagggctcc aggcacacag aggagaggcg tggggcagga ggaggggctg agggacacag 49680 cagagctggc tacgctgagg ggttgcaggg catgatgggg cactctgggg gcagactgac 49740 cccccattag cactggttca gacgccactg gtctgtggga ggcttgtccc actgcctggc 49800 cccaggagcc ctgagtatgc ccggtggggt gacaagcctg cccccaggac ttggcctgag 49860 cctcctcttc agcatggggc aagggcaccc agagccacac gcctcttcct ggaccctgga 49920 cccttcttca tttcatttat ttatttatta ttcatttttg agacagggcc tcgctctgtc 49980 acctaggcta gggtgcagtg gcgtgttgac ggctcacttc agcctcaaac tcctaagttc 50040 aaacgattct cctgcctcag cctccccaga agctgggact acaggcacgt gccgccatgc 50100 ctggctactt tttattgaga cgggggtctt gctatgttgt ctaggctggt ctcaaactcc 50160 cggcctcaag cgatcctccc acctctgcct cccaagttcc tgggattatg ggcacgagcc 50220 actgtgaccg gcccctggcc ccttcttgag ctctgtaacc agcagaggcc actggggcag 50280 atcaaggcag gtgctgggac tctaccaagg cccctcccgc ccgccccaca gcagccccac 50340 cacgaaggct gctgcacaca cctggtccac accacttacc ctgagtgttg tgagctttgg 50400 gaaacatcga atgttttaat cactttcgga gatgttgggg tcaccagccc caggccaggc 50460 agtgacatca aattctcaga ttcgattgat aggagccagt gcctgctcag aggggaggtg 50520 aggctcacag cccacccact gggtgtcaca gcctcctgcc ctggtggaca gtgacaagga 50580 aggggttgag gcaggaacag gggttaggct ggtgcttacc tccccccgact tctggacagc 50640 tgccctggga cctctgcttg aacactgcct cctccacgca gccgtccagg atccttccag 50700 gcagcacaag tcttcctcca ggctccgctg tctgtctgcc ctactgtgtt gtggccctcg 50760 cgctgcactg ggcagggggc ccatgctgag gagctcactg gactgcgtgt tctgccccca 50820 caccatccct gagggaggcg gggcacctct ctttgacccc agggagcaag gccaggcacc 50880 ggaggcagcg cccgagggct aaggcagccg actgatagga gcagacgtca tggagggcac 50940 agggccatgg ctgggagcag ccgagggtcc catggaggac agcccagcac cccagggcac 51000 gggccgttta gggggacatg tgctccccct tcccagagac ggccatgcct gctgcaggaa 51060 ccctggctct gggtcttgct cctgtctgtc ctgcaggctg gcagcattgg agttttcctc 51120 tcaggggatc attaaaccct ggcctagcct ggcccgcatc ccagcacagc cgggcacagg 51180 agaccctgcg tccaaggctg gggcagtggg ggcagcagcc gtccaccccc aggctccatc 51240 ctactcttgg tggccagcct gggtcatgca ggtggccacg gtaggtgagc cacgcaatct 51300 ccccacccca cctcacccca cctgccaccc ccggcaactg gcacactgtg gtctcttctc 51360 aggaccgccg gggcccggtt ggaggccaga gggctgggtg gtaggcccca tgagcagcgg 51420 cgtgcatggg ggttgagggg tgtctgggaa ccagtggctg gggccatagg tgagcctgag 51480 ggaaggggag cggcactggc tggaggggcc ccacagctgg cctgcgaggt gggtgcaggg 51540 atgaccactt cccaccagcc catcttccct gacagccctt gaggctgcag tggcccatag 51600 ccttggagca cagccaccag cggcctccag acagagcagc tgaccatcag ctgtggacag 51660 cctgtatgac gcaggtccta cggcatgttc tgagcacttg cggtgtcctg agcaccatcc 51720 ccagggccat atgggcaact ttacctcctg gcaggtgccc tgcacccacg gaggcttggg 51780 cgagggtgtg tggagtgagt gccgcaccct gagccccaac agggcggcct ggagggccca 51840 gactcacagc agcgagtgcc cagggctgcg gggaggaatc ttcagaggag ccgaggctgg 51900 gtcggctgtc tgctgggtgt gacggacccc aggaccctcc tgggtctgag gtggagggag 51960 tggtcctgct gggccctgac ttctcaactc ctgcagttgg aaagttggaa gaagtcagtc 52020 aggttggggc tcccggcgtg tccccagcct gagtccccac tggccctgag cctccatgcc 52080 cctctctgct tcttcagggt ccaggtggag ttctacgtca acgagaacac cttcaaggag 52140 cggctcaagc tgttcttcat caaaaaccaa agatcgagtg agtggggtgc ctggagggcc 52200 actcccaggc agggaggtgt tgagggcgcc gggagcaagc ctggcgatgg cgaaggctgg 52260 ggctgtgagc tcagggagag tccatggggt gggagccacc tgagtgctgc gggggcattt 52320 ggaagcaggg tgggggtggg tctgcatggt gagtggggca cagggtagcc ccctcttagc 52380 ttcacactgt ctgagaccag ggcctctgca gcgggactcg tggggacacc gtcctgcctg 52440 ctggacacca ggctgggtgg ggcaggacca tccataggtg ccagcaaggt ctcccctgtg 52500 gccacgccct gcctcccacc cctccataca gccccaccct ccccaacagc tccctgcccc 52560 gttcccagcc agagcttggc atcatgctcc ccccgggatt gcaggtgagg acttgggggg 52620 tttccccagg ggctccacat tcacctgcct gctccccaat ccctatcctg tcctccaaga 52680 agtggagtgg cctctagaaa tcccctgcac cccaagttca ggcacctgta aggtggggcc 52740 agggacagag cctcttggag gctgacccaa gagcatcagc ccccaaacaa cgcagggcac 52800 acagagctct gcgtgcagcc cgggtgtggg aggggagccc agctggggcc atccagagag 52860 cccagccaga cccgggtgca ggccctgctc cccgaagccc agagctgggt cagagccctg 52920 aggccgctgc cctccccgca ggcctgagga tccggctgtt caacttctcc ctgaagctgc 52980 tcacctgcct gctctacatt gtgcgcgtcc tgctcgatga cccggccctg ggcatcggat 53040 ggtgggccac gtgcgcggcc gggcgcgggg tcccgggtcc cagggctgag ccttcccact 53100 gggccgttac agaagctgat ggcgtccctg ggggagcccc tgtgcctggg gccttgggga 53160 gtccttcctt ccccagtgcc tgtcccagga tggaaaaagc caaggactca gtgcccaggc 53220 tccgcagac ggctcagcgt agggagaagg gtccccatcg tagacttcca gctgtgccct 53280 tagctactag cggacccaga aggtccacgg aaaggctgga gcatctagga tgtccctccc 53340 tgcccccaca agtgtctctg tgctcacttg agcttctgca ggtcagggaa gggggcgccc 53400 agtccccctg gggaaagccc ctacctgttt ctgggggtgt cttctacccc tcctgggtcc 53460 caaggagtcc cctccccagg gcccatcgtc ctggggccca tgctccaggg acttctggga 53520 gaggtgctgg gggcagcaat ctgcaccgtc aggtccttac cagcctcgca gcagccgcga 53580 tgagggtggg tgggaacttg ctctctctga gtcctgttct gtctccttct gctgttgctg 53640 cttcgagaag tggcggctgc tgggacctac tctgtgccca gcgtgccttg gcaactcctg 53700 ctcacctctg tgtgggtccc aggggacatc agcagggccc tgcggccctc ggtgccggcc 53760 tgtcctgagt catgtctttg gggaccagcc cccaacccca ggcctctctc tctggctccc 53820 tggcactcgg atgctgtgct ctgtgtcctg tttcttctct cccctctcct gcctcgttcc 53880 cttgttcact cgtccacttg ttctgtcctg cctcctggtt tccagaaatc ctttctctga 53940 atgtccttcc gaagatggtg tctccagtcc tttcctgttt tacgctttcc ccatctgctg 54000 ggcctgtttc tcccgagctc acattgggcc ctgacttttt catacccgta gatttcctca 54060 aatgtctggt gccgtttatg cgtaagagtg ctcaggcgct gaggggctct gcagccacgt 54120 gtgtggtgtg gttgtcacca tccagccatc ggggtgaacc ctgccagcat gctggtcccc 54180 cctctggctg cgcagagcag gttcttccct ggagagaagg cctgactgcc gggagcctgg 54240 cttctgggga cctaaaggcg tccatgtaaa cttttgctca atcccccttt tcacctgtta 54300 ccccgtcaca agggggcctg gcatccccag gccagagact ttccctctcc taagaatgaa 54360 cctcctgtct ttgtctaggt cagaagaggg cagaacccac taggagagtt tgagaaggag 54420 aactgggccc tgactgactc tcaagctact ttcctaggtc actccccacc ccaagtccca 54480 gggtcccctg gggcttctgg tttcacatcc ccacagggcc caagtctgtt gtgttcactg 54540 cccgtcccct agcacagcgt ccaggacatg gatgggggtg ggaagatggg tggatgatgg 54600 atggatggtt ggatggatgg tggatgatgg atggatggac ggacggacgg atggacggat 54660 ggatggagtg gatggaggga tgagtggatg ggtggataat ggatggatag gtggatgcat 54720 ggtgggtaga tggatggatg gatggaatag atggatggag ggatgagtgg atgggtggat 54780 gatggatgga tggatggatg gatgatgcgt ggatgggtgg agggatggat gttggatgga 54840 gggatgagtg aatgggtgga gggatgagtg gatggatgga gagatgagca gaaggatgga 54900 gggatgagtg gatggatgat ggatggatgg atggacagat aagtagatgg atagatggat 54960 gagtggatgg atgatgagca gatggttgga gggatgagtg gatggatgga tggagggatg 55020 gatggatgga cagatgagta gatagatgga tgagtggatg gatagaggga tggatggatg 55080 agtggatgga tggaggaatg agtggatgga tggagagatg gatgatggag aagtggatgg 55140 atggatgagt gagtggaaag atggatgggt ggatggatga tagatggatg tccagatact 55200 tctgtgggca cttagtttgc aacaacccca ttaaaaatca ggggaaagtg gatcagttga 55260 aagaaaagac aagaggagct ggccatcacc aggggccttg tgagcagtga ggtctccttg 55320 gtcagtgacc ctggcatcga tgatggtctg ggacaaaact agcttgttgg ccatgccctg 55380 gtcactgtcg cagcagctgg ttccaggtgg cttgggggcc gcttgtcctc agaagcagct 55440 tagggacgtg cctcttggag tcagcacctg gggataggag cttcctctcc ctgtctcttg 55500 aacactgtcc agccttgttc aaggcagctc tggccttggg gaggccctga gtgttcccac 55560 atgctctctc tggccatgta aggcccctcc ctgggagcct gttgtcagca caggcagaac 55620 cagtgtgttg ctgttgggtt ggggctaccc ccaatcccgc agatgtggga tgtaccctcg 55680 ctgtctgcct gctgggctga gcagtggcca gcccagcatt cctcagttag aggccctcct 55740 gcaggatctc cgcagtaggt ggggaggggg caggctgcct tgtctcccag gtgttagagc 55800 tctgatgtgg gggttagccc cgggtgggtg agtaggaggc ccccatgaac ccgagcctgt 55860 ggaagccctc gggcagcaag tccttgcagt ggtgctagag gggccagggc cgggccagcg 55920 ctgtgtctct ccacagctgg ggctgcccaa agcagaacta ctccttcaat gactcgtcct 55980 ccgagatcaa ctggtgagtc cacactccag ctcccaatag ccaggcgctc agaggcctgg 56040 gaccagggtg gggtgggatg agtctccact ccagctccca atagccaggc gctcagaggc 56100 ctgggaccag ggtggggtgg gatgagtctc cactccagct cccagtagcc aggcgctcag 56160 aggcctggga ccagggtggg gtgggatgga cagaggctca cactgcctgg tccctgaggg 56220 ataatgccca gcctcaaccc agcagccacc caggttcccc aggacacatg tgcccttagc 56280 cctggctgtg gtcaatgctg ggaatgtccc cttcaagagg agcagtttga gaattgtgag 56340 ttcccagcca gttccacagc ctccacacgc tcttcctgag cccagtgaga gatgcaagga 56400 agcccgtctc ccagtgaggt ggcggcttct cttccagttc accatcttac ggcaaaggaa 56460 ggcacctgcc ccgggcaggc agtgggaggt gactgcgggg caactggggt gcctggtcca 56520 gagattaaga cctgtcccca gaacctgcaa ggcatgtccc cagtgcctga gcccctgtcc 56580 gcatcaggca aggagcagat ggccccctgc agccatgccc ctgcctgttt atggatgagg 56640 aactgagact cggggaaacc cagggggctg tgggttagat agcccgacct ccctgctctt 56700 agggacattc atgggagccc ggcttcaggg acccaggtga aaaaaacagg ctacccagtc 56760 tggggcccag gctgctgttg cctgtcgtgt ccagagagga gaagctttgc cacccttggt 56820 agtgtcatgg gctgcaggcc aaggctccat ggagactcag ccatgggccc tggcctcaca 56880 agcacctcct ggggggcctg cctgctgcag tcctgctcca tcctcctctc ttggggaacc 56940 ttcccttccc tcctccttat ggtcccctcc aaaggcaagg taggctcctt tggtccagcc 57000 ccaatgagca gcacatgctt ggggccagtg gaggccaatg gttatggccc cagccccagg 57060 gtggctgggg gacactagtg gctgtggtgc cctactgtgc tgcctccttt ctcttcccag 57120 ggctcctatt ctgtgggtgg agagaaagat gacactgtgg gcgatccagg tgagtgccct 57180 accctgcccc cctcccgact gcagtggtgc tcagtaagca ctgaggacca acccagactc 57240 agtaagtagg gaacccaggc tcggtgagca ctgaggacat acccagtctc agtaaatgct 57300 aagaacaaac ccaggctcag tgagcactga ggacagaccc aggctcagta agcaggggac 57360 ccaggctcag caaatgctga ggacaaaccc aggctcagta aacaggtgac tccaactcag 57420 tgagcactga ggacaaaccc agcatttact gacccaggct cagtaaatgc tgaggacaaa 57480 cccaggatca gtaaacaggg acccaggctc agtgagcact gagtacagac ccaggcttag 57540 taagtagggg acccaggctc ggtgagcact ggggacaaac tcaggctcag taggcagggg 57600 acccaggctc agtgagcact gaggacagac ccaggctcag taagcaggga aaccaggctc 57660 agtaaatgct gaggacaaac ccaggctcag taaataggga aaccaggccc agtgaatgct 57720 gaggacaaac caagactcag taaacaggtg actcagggtc agtgagcact taggacagac 57780 ccagcattta ctgactcagg ctcagtaaat gctgaggaca aatccaggct cagtaaatgc 57840 tgaggacaaa cccaggctca gtgagcactg aggacagtcc caggctcagt aagcatggga 57900 cccaggctca gtgaatgcca aggacaaagc caggctcagt aaaacaggtg actcaggctc 57960 agtgggcact gaggacaaac ccagcattta ctgacccagg gtcagtaaat gctgaggaca 58020 aacccaggat cagtaaacag gggacccagg ctcagtgagc actgaggaca gacccaggct 58080 cagtaagcag ggaaaccaga ctttagtgaa tgctgaagac agacaggctc agtaagtagg 58140 gaacccaggc tcagtgaatg ctgaagacaa actcaggctc agtaagcagg ggtcccaggt 58200 tcagtgagtg ctgaggaccg acccaggctc tactgctctc cacacaattt tcccagggat 58260 ccctgaggac ttcctgaccc cctctgtctg cttcaccacc tgaatctctc cctccactga 58320 cccatctgtg tccttgctgt tttcctgggg tggagagtgc acaggccagg tccctggctg 58380 gctcctgggt gggtgaccta gttcatgact gggtcccatg tctccatctg agaccagaga 58440 gggtctttca cacccacccc tatcatgttc cagaggggtc agtagatgcc tgtgctgaga 58500 ggggttccgt gggggaaaac caggtccact gagcctccat ctccgttccc tccccaccag 58560 ggcagcggga tagccgctct ctggtgtctt cctgagcgtc ctgcctcacc cactgcaccc 58620 tccatcccac cctgggccta gagtgggcgg cccaggagga ccatggtttc aagactccat 58680 ctgccctcgg ccctggcggg ggtcagccaa aggccttggt ggctaagact gtcctgacat 58740 gggagtgagg gtcaaggcag accccagaca cacacctggc tttgtgtggt acctgcccgc 58800 gaggcctgtg gggtcaggcc ccagccccag ccccggcctg ctccagagct ccttcccttt 58860 cctgactccc aggtcatcgt ggccataata agcttcctgg agacgatgct tctcatctac 58920 ctcagctaca aagtgagtgc ctgcccggga tggcacctca cagggggtcc ccaccctccc 58980 caccctcccc agcctccccc acctccccca ccctctccta tttccccaca cttcccagcc 59040 tcatccactg acctccaggg tgggctcctc gccctcttcc ccaccctgcc cctcccctgc 59100 tgggccccac ccccaccctc catcgccccc gctgataccc cccgtttggc cccagggcaa 59160 catctgggag cagatcttcc gcgtgtcctt cgtcctggag atgatcaaca ctctgccctt 59220 catcatcacg gtgggtgagc cccagctgcc aggagtgcgg gccctggagc cccagccctg 59280 acctgtcccc ttcacagatc ttctggccgc cgctgcggaa cctgttcatc cccgtctttc 59340 tgaactgctg gctggccaag cacgcgctgg aaaacatgat tgtaagccgg ggcggggggt 59400 gcagctggga cttgggggggg ccaccctcag cctcaccggc cctggaagac actgtgcgac 59460 gtagcctgcc acgccccggc cctggcatga cctgtagagg accgggaagc cagggcagca 59520 gaaactctgt ctctgctcct ggaaaacatc caagccaagc cccgaatgcc ctccttccag 59580 gaagaaactc aatcccagag cttttcctaa gcctggaaat gaaatggctg gcaggaggag 59640 gagggacaaa gtgaagggtg tgacaaaccc aggccacgag gaccagggcc acaaacacca 59700 ggccacacgc aaactggggc cacggggcca caggcaggcc ctgtgctgag catctcagga 59760 aacctgggcc acggggccac aggcaggccc tgctctgagt gtctcaacat ggtccctgtc 59820 atgtgaatgg cagcagtcag ttccctaggc gcccaccctc tccaagccag accccttgac 59880 tcacagcccc cattcctgcc ccagtggtaa atcagcgtta ccatgctggg tccaagcctt 59940 gcacactaac cagccctctg acctgagact taagcctcat ccccggggat gtaggcaaga 60000 tggggacccg tcctgagaga ggacagcaga gggggtgccc tacccaggtg caggctgccc 60060 gtgggcctca gcggagacgc aggtgtggcc aggcgtgggc tgccccttgg gcctcagccg 60120 agacacaggt gtggccgtgg gctgccccgt gggcctcagc cgagacacag gtgtggccag 60180 gtgcaggctg ccccgtgggc ctcagccgag acgcaggtgt ggccaggtgc aggctgcccc 60240 atgggcctca gccgagacac aggtgtggcc aggtacaggc tgccccgtgg gcctcagccg 60300 agacgcaggt gtggccgggc cgtctgcttt ccactgtcct tctagtctct attcattggc 60360 tcctggcggg gtccacagtc cctgcccgct gacagccacc actccttcca cagaatgact 60420 tccaccgtgc catcctgcgg acacagtcag ccatgttcaa ccaggtcctc atcctcttct 60480 gcaccctgct gtgcctcgtt ttcacggggt gagtgccggc cgtcagtgtg agcaccccag 60540 gacgttggga gggcccgaga ggcaagcagg gccgggcgag gggatacaga tgcctatgtc 60600 caagctatcg gggcagaaaa ggccacagtg cctgggctgc gggtgtcggg ccaccaagct 60660 gggactgagg tcaggaggca gctccaagcc cacgtcccca gtacacgagc agccctgcag 60720 cccgactcct ccaaggacag agatacccag atctggcttc ctggtctatg ccatggacgt 60780 agagaagggg actggcccct aggccaggtg gggtctcttg gctgaggccc agctgaaagc 60840 agggtctgga ggcagccagg gtaaaggtgg gggtgcccag agctgcgagg gcctccagcc 60900 cacccaggca tgcccactgt gcccacctgc ctgtgtcctc gtggagggct ccatgttgct 60960 gctctgcctt gggtcccagc gaggcctggt caccacttcc cgtccccagg cagggatgtc 61020 aggcaagcac tgtgccctgg gggagggaga gtgccctgcg tttcccgcct cccttccccc 61080 ctgcccctca tgacagactg acagacacag agctgagtgg gcagattggg gcatccatga 61140 ggatagcatc tgggacctgg cggcgacccc agccctgccc attagacctc ccagcctcag 61200 gcctgggcgc ttgtctggct gtgccgggca gaggcctgag tgtggtgggt aaaggggcaa 61260 ggctctgaga tgggggtaga gggccagacc ccaggcccac ccctgtgtca cccaagccca 61320 cgctgatgac acagccctgc atcccctgct cccagagaat gttccaggga cctaggagag 61380 agccacccgg caggcaggga ggctccgggg aattcgccgt gaacagaggc cgccatgctg 61440 tggccaagct gcattgtcag ccagcgtcag gcaggaggtg gctccggcag agcttgggga 61500 cagatgggca gggctgaggg cctgatgcca cccagctgtc aggagggcgg ggctcgcctg 61560 gtgatgcaca gctcagtctc ctgggcagtg agggtcccgt gggcaggcag gatctctgag 61620 gggccacggc cccccagctc ctgggcccca ggccgcccct cactgccagg ggttgcagga 61680 cctgcggcat ccagcacctg gagcgggcgg gcgagaacct gtccctcctg acctccttct 61740 acttctgcat cgtcaccttc tccaccgtgg gctacggtga cgtcacgccc aagatctggc 61800 catcgcagct gctggtggtc atcatgatct gcgtggccct cgtggtgctc ccactgcagg 61860 tgggtcctct gggcaccagc cctgggtggc accagcaaag ggacaggcgg gtgccagtag 61920 agggagggtg ccactgaggc tgtggcacag tgcgggggcc actcccagga ggggacagtg 61980 aggccaggcg ggtggtgcct gctccgttgc acgccccccac tgagggtcta cggcgggtcc 62040 ggtggtgctc agcatggtgg gtaatgatgg agtcccgtga gctggcctct tccttctggg 62100 gagatggtgg gtctccagtg ccagggtgac ctgcccctcc caggcccagg cagagtgcag 62160 ggaagggtca aggtggacag ccggcccatt tcccatccac agccaggtgc agcagcagct 62220 gccaggccca cagggggcac acccccccgg ccaccccagt ggcttccccg tcaccactgc 62280 tgtggcccac tgcccactga gcagaggagg ggacggggca agacctcagt gggaaaggtg 62340 gaggcctgga gagggcagct gcctcagggt gtgaagtgct tgggcctgga ctgcctccga 62400 cacctcctcc aggcacccca gcccaccctg gagggaccct gctattgggg agatgggaga 62460 aggaggggac ccctgtgggt ggtggaacat tttccaggag gctgggtagg aggaagagcc 62520 tgaggaggtg gccagggcct tctgggagac agacccccag gtggctgcag gatgccgggg 62580 agacagggca gtgctcctag ggagcctctg ctgaccccag gctcagcccc agctccctcc 62640 cgctaaacag cagtgggcgt ggcccaggta tgggcccagg ccaggcctgg ctcttctcct 62700 cactatatcc aagccaaagc tgtggcacca gctgtacggc ccccagcgtg ggccatgttc 62760 tccacatctg tggcttctgt tctcctgagt tcagatgggg ccgtgcgcgt ctttccatct 62820 ggttgtcggc cactccaccg tccagtgcca cgagtcccgc tcctgtgagc tgcccgctcc 62880 tctttggtct tccccctggt tctcgctgat gagcgagtct ctgtgttcta gaagaagcca 62940 gttgtgtgtg gctttcccgt tacttcctgc tctgtgaccg cccctctcac tttgcttaca 63000 gaatcttcca ttcacggatg gtcttgattt ttttttttta aattagagat agggtctcac 63060 tctcattttg ttgcccaggc tggcctcgaa ctcctgggct caagcgatcc tcccgcctca 63120 gccccagaaa tagctgggat tacaggcggc ttggctttga ttcaccaatc tttcccttat 63180 ggtttctgtt ttcctgtctt tactgaaaag atcattccct ccctcgatca taaacctggc 63240 ttcctatttt cttctaaaag tgtaaagctc gcctctcacc tggagggttt cacccaccag 63300 gaaccaccat gtggggtggg gtggagctgg gttctcccct ctgacgcctg ctcccccca 63360 ccctgcattc tgctcctttc tctgcgcatt tcataaccag gcaagggcgg gagtgagggt 63420 gggagtgagg ccaggagcac agtgtgggggg gcactccgtg cagtgacact gcctccctcc 63480 tcggccctcc tgccccaatc cgtaaatctc acctcaaatt ctttacctta attacttctg 63540 caaagaccct tttgcaaatg aggactcatc ctgaggtgca gggggacctg ctttcagggc 63600 catccttgac cttgctacgg gcccccagcc tccgtccctg gtccgccccg gccccacactt 63660 caccacgtgg ccggcacctg ctgaggccgc tgcacccaga tgctctgcag aggcgttgac 63720 ccatccagtc tctgaattcc ccacaagccc ttccagagaa acatccgaga ggcccctggc 63780 ccagccgagg tcagaggaag ggtcaacagg gccaatgcgt ccccctttcc cctgtgggcc 63840 cacggcccag ccacacgcag ctccaccttc gggctgcgtc cggctcctct ccccacccca 63900 cacaccccag agcgaagagg agccccagcc ccagccaccc ccagggtcgc tttcaaataa 63960 agcaggagcg aagcgctctc tcccgtgctt ctcacgagac cgtggcaccc aggggtaagg 64020 gccaaatcgg gatgtgcagc aggcctgttc catgtccctc tgctgcgtcc acagcctccg 64080 ggccggggct gccttcccat tctgctcctg aagcaccagg ggagccccca cctcccctta 64140 tctccattaa gaagtaagac aaggccaggc gcagggctca tgcctgtaac cccagtactt 64200 tgaaaggcca aggcgggagg atcgcttgag cccaggaatt tgagatcagc ttgagcaacg 64260 tagagagact cccatctcta ccaaaaagta tgaaaattag ctgggtgtgg cggcatgcac 64320 ctgtagtccc agctacttgg gaggctgagg caggagaatc gcctgagccc tgaggttgag 64380 gctgtggtga gctgtgatct cgccatcgca ctctagccta tgcaacagag agtgagaccc 64440 tgtttcaaaa agaaaaagaa aaaagggcca ggcacaatgg gtcctgcctg taatcccagc 64500 actttggagg gccgaggtgg gtagatcact tgagatccgg cgttcaagac cagcctggga 64560 aacatggcaa aaccccgtct ctaccaaaaa ataggaaaaa ttagccaggc atgatggcac 64620 acagctgtag tcccagctcc tcgggaggct gaggtgggag gatcacttaa gcccaggagg 64680 cagaggttac agtgagccaa gatcacacca ctgcactcca gcctgggtga cagagcgaga 64740 tgccatctca acaccatctt aaaacaaaca agacaaggtg actccaggtg caccaggtcc 64800 tgcaggcatc acacctgcac tgctcttcag ggaaattcac ggaacaaatg cgccatcgtc 64860 acgagaactg attgcatcga tgggtatggc catggtgaca agtgaccgac agcccagcag 64920 cctgcacgca gaggtgtcac tgtagctcga gctccgtgtc cacagtgggg tccctcagat 64980 cagccactgc ctgactgcct tgtctccttt ctcccgtgtg gggcaggcag agcaggccct 65040 gagtgggaca agctctgagc gaggcaggga ggaaggcggg ggcagggcct gggggctggc 65100 gcaccctccc tcccatcagc cctgccggac ctggtgctca aacctgaccc aggtgggcct 65160 gtgctgtccc tggcagggct gggggtgatt gggacagtga tgccgctgac cccaccgtct 65220 aagccgctcc ctgcctcctc cgaatgactg gaaagactga gcctctcact ggcgatggta 65280 agggtgggct gcagtgccct tgcccttggt ctccactggg ctgaatgcac cagtaaaagc 65340 ccttgaagca gagtgatgac cccgaggccc tcgctcacga gcgtccttct ggaacacagc 65400 agcgccggct gggtctcctg gaagtatcct ccaggctctt cgatcagcaa gacagacagg 65460 cagcttaaac agcagatatg tatcctccgc cagccctgga ggacagaatc ggaagtggag 65520 gggttggcag ggctgaccct atcaggccgc tttgggggag attgtcccat gcctctctcc 65580 agcttctggt ggggccgcaa tccctggggc tgcttctacg gtggctgtag aaacctcagc 65640 ctctgccccg tgtgcacttg gcctcttctc tgtacctctc actggattta gggcccactc 65700 caacccaggg tgaccttatc ttaaatcatt acatctgcag agacctattt ccaatcagat 65760 cacatggcga ggttctgggc agataggact tttagggtca ctacggagct gccgtcatta 65820 gctccttcat cctcacggcg gccctggagg gttgccgtgc catgcagcca tcttgtaggt 65880 gaggaagctg aggctcagag tgggggacgt gagccctggg gtgtctgaca gcagagcccc 65940 cgccagcacc atccgcgggg aagcctctgt tccggtcgcc ctggagtctt gagcacctcc 66000 cagctgtgga aactgttttg tgtggcaagg cagtggagcc tcgtcaccgg aacaaagcag 66060 gcgctggata agtgcaatgc gatggtccca tttagaccag acgatagcac atcagccatg 66120 cagcccacag tccatgggag ctcctgccat tgttcattta acacgtgttc aacaagccgg 66180 gcaccatgac tcagcctgta atcccagcac ttcaggacga caaggcagga ggatcgcttg 66240 agcccaggag ttcgagacca gcctgggcaa tgtagtgaga ccccatctct acaaaaaata 66300 aaaataaaac tagctggtca tggtggtgat gcacctagaa tcccagctac tcaggaggtt 66360 gaggcaggag gatggcttga gcccgggaag tcaaggctgc agtgagctgt gattgcacca 66420 cggcactcca gcctgggtga cagagtgagc ctccgtctca aaaaaaagaa aagccaaaga 66480 ctttcaccta gaggccagtg gggccggtgc tgggaggccc cggtggcctc tgttttggat 66540 ctgtcccctt tgagtctcaa cacccagagc ttgcatctgg ggagcatgag ccagggcagg 66600 cagcatcctc agaccagcag cctcaaacca cctgcccccc agacataggc tcctgacagt 66660 gaggcctgcg agtgcctgga agaccggggt ctgaggcctg atttggccac gcttaccatc 66720 aagagagtga tccccaatcc cacgggctga gcctccccac cctcggttta ctccacagtc 66780 tccagccgcc cctcctccct tggtccccac acatcctgcc agccgggcct gcgtcctgct 66840 ctgtgtcatc tgaggctatc agcatctaca gtttccatgt gggaaaggcc cccctaatgt 66900 aggtgtcacc ccccggccgg ccctgcccca ggcccctaac agacagtcgt gtgtcagggc 66960 ccaggttctt caccgggagc cctcgctccc caggcctggt cgctggtgct cacctgtttc 67020 tcacctgcag ttcgaggagc tcgtctacct ctggatggag cggcagaagt cagggggcaa 67080 ctacagccgc caccgtgcgc agacggagaa gcacgtggtc ctgtgtgtca gctccctcaa 67140 gatcgacctt ctcatggact tcctgaacga gttctacgcc cacccccggc tccaggtgag 67200 gccccttacc gtggcccagc agacgactcc ctcccggccc ctagagacgc catcctctcc 67260 ccaggactgc ttggcaagtc cctgagtcct ctcagccttg gtttacccct tcagtgaggg 67320 cagatgcctc cctcccggcg cccagagacg ccatcctctc cccaggactg ccatcctctc 67380 cccaggactg cttggcaagt ccctgagtcc tctcagcctc agtttacccc ttcagtgagg 67440 gtggcagccc acagtcaggt ggaggggccc tgcgggggcc cctcttttcc ctccccaccag 67500 atgcaagatc acagtgagct ctagggccca gaggtggtgg gcacaaacac agtcctgaag 67560 gcagggccgc ccgggcgggg caggggctgg ctcagagggt ctgaccctcc gcctggccgg 67620 caggactatt acgtggtcat cctgtgcccc acggagatgg atgtccaggt gcgcagagtc 67680 ctgcagatcc ctctgtggtc ccagcgggtc atctacctcc agggctctgc actcaaagac 67740 caggacctca tgcgagccaa gtgagtgctg gtgggcggag ggggtggcat gggggcacct 67800 tcctgagtca ggtcggctgc tcagggctga ggcattgacc gtcgctctcc tggccaatga 67860 gagccatgag agcattatag actatcccca gggtggacca tctaggtgga ctgtccaggg 67920 tggatcgtcc ggggtggacc atttagggtg gatcgtctgg ggtggaccat tcagggtgga 67980 ccttctggga tggaccattt aggtggacca tacagggtgg atcatctgga gtgaactgtc 68040 aagggtggac catccagggt ggaccatctg gggtggacca tctaggatgg actgtctggg 68100 gtggaccatt cagggtagac cttctgggat ggaccattta gtgtggacca tccagggtgg 68160 attgtctagg gtgggtcatc tggggtgaac tgtccagggg ggaccatcca gggtgggtca 68220 tctgggatgg actgttcagg gtggaccatc cagtgtagat catgtggggt ggaccatcta 68280 gggtagactg tccagggtgg accatctggg gtgggctgtc tggggtgggc cattcagagt 68340 gaaccatctg ggatggatct ctagggtgga ccatccaggg tggatcatct ggggtggacc 68400 attcaaggtg gaccatctag ggtggaccat ctggggttgg tcctctgggg tagatcatca 68460 ggggcggacc gtctggggta taccctctgg ggttgtctgg ggtgggccat ccatggtgga 68520 ccctcttggg tggaccatct ggggtggatc gtctggggtg gaccatccat ggtggaccct 68580 cttgggtgga ccgtctgggg tggatcatcc agggtggact gtctggggtg gaccctctgg 68640 ggtggattgt ctggggtaga ctgtccgggg cctcttgcag tttctctagc tcaggtccca 68700 ggcccagatg agcaggaccc tgcagccagg cccttgtccc tgcaccatac ccactgtgga 68760 gcagcccagg caagcccaac ccagctaagt ctctgtctcc cttttcaggg tgaggggcag 68820 ccttttgcga gctccacctt cccctgctcc aagtctaggg aaatctttgt caagttctag 68880 ggaggctcaa aatagaacag gggcgggaga gtcagctgct gtgagtcaag gtgggagaac 68940 gggctgaagg tagagttcct tttaaagaca aattgacaga gtgacaaggt aacaagagta 69000 tattattacc tggaactttc cagaatgtgt cggtgcactt tctgggacac tccctggaaa 69060 accctcctgg tgacattttc attccaggag cctgaatgtg tccttagtgg catagtgttg 69120 gtggtactcc cagggtctct cctcatcact ccccctcccc ctgccatgtc cagagcccca 69180 agctggaacc cattgcctat ggaacgccac ctcttttgtg gtcccgtccc cagcacacac 69240 aggcgatgca cctgcttggg cccagggagt ggggagaggg caagggcgta ggccattccc 69300 agccaggcag ggatgagccc agggctgtgg gtacagggcc tggggcccct gcggagcaga 69360 cagtggtgcc agtgatgtgg tggggttccc tgccctgggg cagaggcgac agtttcttag 69420 acagcgtctc agcagtgcta ggtggtttct gcagctgggc tttcaggaga cccaggaggc 69480 gctggaagtg accacccagg ttcccagacc acagagtagc caggccaggg agcggacagg 69540 gtctctgccc ccagattccc ccctccctcc tgcaccccaa cccagccctg ggtgaatgtc 69600 tcatggcaac atacaagatg ggtaccccgg aagccagtgc ccaggtcact ggcacacacc 69660 taggtggggt ctccaccggg cctgctcctg ccaaccctgg acccctagcc cctgacgcct 69720 gggagtatgg acaaatccag gcagccccag ccagcagagc cccctcgcac gacctcctga 69780 tgcccctcct acctggccaa cttagggaca agctgggggg ttgcttcaga gaacagggcc 69840 tgggggagga agggcaggca ctgccctagg aagcaccatg ggctcccact cagggccgtg 69900 gccaggagaa gctgtcagct ggtgtctcca ggacacacca tccatagcat ctgaccccct 69960 gccccccaccc gctgtcagcc tgcacacact cgggggacag gtgtggctcc tgacccctgc 70020 ccccacccgc tgtcagcctg cacacgctca ggggacaggt gtggctcctg aaccctgccc 70080 ccaccctctg tcagcctgca cacgctcggg ggacaggtgt ggctcctgtg ccttctcgag 70140 tgtcggagct tggagtctcc tagggtgtcc aggagtcctg acccggctca gagcctgcca 70200 gggatgggcc agggagtctg gagaggccca ggatgcctgc gggggggggg gggggggcac 70260 tgggataccg gtgggggggg cacagggatg cctgctggtg gagggcacac aaggatgccc 70320 gtgggggaca ctgtgatgtg ggttgggggg ggggggggca gtatggggat gcccactgag 70380 ggggcactgt gactcctgac cagcagagag taggggcctc ctcccgcctt ccatcctccc 70440 cgccttccat cctctccgcc ttccatccag ccgtcctctc agtctctttc tgtgcacctg 70500 ctgcaccagc ctcctcccag aggaggtcct ccccacctca cctccgcacc cccggctgca 70560 ctgcccacct cccctgctcc acccacgctc aggccctggt gcattgcagg atggacaatg 70620 gggaggcctg cttcatcctc agcagcagga acgaggtgga ccgcacggct gcagtgagtg 70680 aggctgaggc cctgcccagg cgggaggggc accgtggggc cggggagcgg gggtccctga 70740 gggaagagac ctgccccagg ctgccggtgc cgcccagcag cccacagagg ccagcccgtc 70800 tgcactgacc aaccacccac cccgccagga ccaccagacc atcctgcgcg cctgggccgt 70860 gaaggacttc gcccccaact gccccctcta cgtccagatc ctcaaacctg aaaacaagtt 70920 tcacgtcaag tttgctggtg cgtctggggc acacgtgggt gatggtgtat ctggggcagg 70980 gcacgtgtgc acacgtgggt gatggtgcat ctggggcagg gcgcatgtgc acatgtgtga 71040 cggtgcgtct ggggcaggac gcgtgtgcac acgtgggtga cggtgcgtct ggggcaggat 71100 gcgtgtgcac acgtgggtgt cggtgcgtct ggggcagggc gcatgtgcac acgtgggtga 71160 cggtgcgtct ggggcagggc gcgtgtgcac acgtgggtga cagtgcatct ggggcagggc 71220 acgtgtgcac gtgtgtgtcg gtgtgtctgg ggcagggcgc gtgtgcatgc tgttgggtga 71280 tggtgcgtct ggggcagggc gcgtgtgcac acgtgggtga cggtgtgtct ggggcagggc 71340 gcatgtgcac gcagttaggc gagctgtgtg gggcagcggg aggggctggc cctggagctc 71400 ctcacacaag cacaccagga ggtgctggag gggacggcag acccccatcc tcaccgcatc 71460 cgagaaggga cctagggggt ccaaactctt cagatgaagt cttatgctgg gatcctgggg 71520 tcagtgaagg cagggtcaga ggtcaggtgg gggcaggagc accgtctgat gagcacctct 71580 atgggcaggg accatgccgg gtgcccgggg aacggggggc aggccccatg ccaggtgccc 71640 aggggacagg ggtcagggcc cacatggagt gcccaaggca caggggccag ggcctgcccc 71700 gccctggaac tcctcgctga gctgggagag aagcacagga gcgatggaag gtccaccgag 71760 gctcagacca agtagggggt tgaggtccac agactctcgg ggcagagatg ctgaagccgg 71820 acagcagaca cgggggtgcc aggcaagggt gcatctgcat agcaccttca ggaagtgagc 71880 aggtactgtg ggggaggaga gagccggcag agcggcaggt ggaccggcct cccccactgc 71940 ccgcagacca cgtggtgtgt gaggaggagt gcaagtacgc catgctggcg ctgaactgca 72000 tctgcccggc gacctccacc ctcatcaccc tgctggtgca cacgtcccgc ggccagtgag 72060 tgccccgtgc cccgggggac cgacctccat ggcggggccg gcgcagggag acaacgcagg 72120 gcctgcttgg gggcggggat gggcttccca gaggaggggc acatggcggg caaaagtcct 72180 gcatagggag gggatccatg ccaggggaag cagagggggg cacctgcaga cccagccggg 72240 gagaaggggc agccatggcc gagggtgacg ctcccctggc cccgccctgg cccacaggga 72300 gggacaggag tctccggagc agtggcagcg catgtatggg cgctgctccg gcaacgaggt 72360 gtaccacatc cgcatgggtg acagcaagtt cttccgcgag tacgagggca agagcttcac 72420 ctacgcggcc ttccacgccc acaagaagta aggccgggct gcatccacag ggctggcgct 72480 ccagggctgc tctgctctgt gccctcccca ccctcccggt caggcacagg ggtggccctg 72540 gggcggggct gcagagggct cgggggaggg catcaggtca tcctgcctgg cgagggcagc 72600 cgcaggactg ggctccgggt ccacataaaa acctgccacg cggctcctcc ctgaggcttg 72660 tgggctgacc ccagctctct ggtccccaac acctctggga cgggagggct cagccaaggt 72720 ccctgacccc aaatggcccc caggaggaag acgcggagct ccggtgggga ctctggtgat 72780 ttgcaggaag ggcaggcagg gagcgggaca gggcgggtga gcggcggtac ctgaagttgc 72840 cggtgcctct gcccaggtat ggcgtgtgcc tcatcgggct gaagcgggag gacaacaaga 72900 gcatcctgct gaacccgggg ccccggcaca tcctggccgc ctctgacacc tgcttctaca 72960 tcaacatcac caaggaggag aactcggcct tcatcttcaa gcaggaggag aagcggaaga 73020 agagggcctt ctcggggcag gggctgcacg agggtccggc ccgcctgccc gtgcacagca 73080 tcatcgcctc catgggtgag ccgggacagg cgcgcgggac tccctgggcc tgctcctttg 73140 gcgggagacc aggcgggaca ccggcaggtg accaggtggg atgggagacc aggcaggaca 73200 gggggaggtg accaggtggg acaggagacc aggcaggaca ggggcaggtg accaggtggg 73260 acgggagacc aggcagggcg ggagaccagg tgggacagga gaccagaccg ggcagggcag 73320 gagaccaggc caatgtggcc cccagaccca gttcctcttg gcctatgcct ccaaccttgg 73380 acaggtggag tctctctggg cctgtttttg aatctgtcaa acaggtgtcc ccgccttcct 73440 gtggccacct ttgtgggcat tgctcactgt gtccaagtgc ctgtccaagt ggggccgccc 73500 acaggaccgg ttggcagctc aaccggaggc tcctggtggt cccatcagcc cggagggtct 73560 gcttcacgtg tgtccctcaa acagtcggga gtcctgacgt ccactggggc caggagttgg 73620 cggaatgagg tcgcagtggc cgagggcttt ggcctcttct cgtgccttca gggatcctcc 73680 cggggagccg cttaccagac agggtcaggc tgcctctgag caggtggagg cccatggccc 73740 ctagggcacc acccatagtg gtgttgcccc ctccccagcc aggccttcct gggggacagt 73800 tagggagcag ggccaggcca ggaagccact caggccacag acccacagcc gggccagcat 73860 gttgccacct ccgtacagtg gcccaggcag aggctgaccc tatggggcac cccagcacgc 73920 ccaccctggg gtgttgttac acggtggctg ctggggcacc aggtggttca gtgcagtggg 73980 gcacagtctc caagacccag agggccctgg ggtttggaga cgtgccgatg cggagcccac 74040 cacctgccag accccgcagg ttcccggccg ccgtctacgg cagctcactc ggggggccgg 74100 gcctggccgc agggcactgg ggaggcaggc tgctgctgcc tagccacacc tccaccttca 74160 cctgcgcagt aggcactctg cccccaggtg gcttccagga aaccagggtg actcgggcaa 74220 ccctcactgt acccacagag gccctgggcc atacctagag gtccacaacc cccatctggc 74280 agcctggggt ggtgcaggag tggcagagtc tgctcccaca ggcactgagt cacccagctg 74340 ctccccacct ggccccatcc accaggcagc ctgaccagct gcacaggccc ctaaggctga 74400 gacccccgag cccagaatca gccaaccccc tcctcaggca tctggtgctg aggccacagc 74460 agctggcctg ggtggcaccg atggggcact ggggccccct gggtcttcgc tcaacatcat 74520 cgccacccca gaggccactg tccctgttgt atggaggggg aaactgaggc atagattgaa 74580 gctcctcagc tggagcacag gagccaggcc atgacagggt ctccagagct gactgtgttc 74640 acctgagctc tgggaactcg ccgcccatgg agggtgggag tcgggctgtg gccaagcaca 74700 gggctctctt ccagggacag tggccatgga cctgcagggc acagagcacc ggcctacgca 74760 gagcggcggt gggggcgggg gcagcaagct ggcactgccc acggagaacg gctcgggcag 74820 ccggcggccc agcatcgcgc ccgtcctgga actggccgac agctcagccc tgctgccctg 74880 cgacctgctg agcgaccagt cggaggatga ggtgacgccg tcggacgacg aggggctctc 74940 cgtggtagag tgagtgctgc cttggagacg gctcccagtg gggggaggag ccgcccatga 75000 gtgcggggga tgggtgtcgg agcatccttg gtggtccccc atgctctgaa ttgcagcttc 75060 tggacagctc cgtggaagtc cttgtttgac aaatgaaatc ttcagggggc ccaacacaga 75120 catcagggcc acatcaccct cgtcgccggg gagcactttt gagtgtcact gagatggggt 75180 gtgctgggct acaccctttc cagttggggc tgggggtgca gagctaattg gagcgaggca 75240 gctcactggc acaggggctg tcaggcacca ggcagcgcca ccctcagaga ggggcccgtt 75300 cccacccacc tcaccagccc catagtggcc cggccactct ctgaatcagg atggagctgg 75360 gcagtgaccc caggccatcc tccacccagt gccctaggtc tcccccttag cactacagag 75420 cacagagggg cacagcccgc ctgaccaggg gtgggtgtcc tctgagcagg gtccctgtgc 75480 aacccctggg caaggcagtg tcccagcctg gaaaccacag cccgtcctga gttgttgtcc 75540 tggcctaggt ttggggccaa gtcctcctgc ttcaaatcat gagacaggag gccccactct 75600 gttctcagca gcttctgcct tttggcctca gccaggacag acaagtgccc cagctgcagg 75660 gcccgaggtc catcctcagc ggggctgcct cactctgtcc tggcctttgc ctctggggtg 75720 gggtcaacac actgtaatga cagcccagct gctgggaaac agccctgaac cattgcatgt 75780 gtgtgttggg tgctgctggg gacggggtgg tggcctgctg gggacaacag cctggctgga 75840 caagtatgtg ggtaagagcc caaggccaga gtgcctgccc caccagccgg gggtgctggg 75900 gatgtcaggg aggcatggcg ggcgggcaga gccctgtggg ttttgcatgt ggctgaaaag 75960 cctggtctag gctgtggtgg gaggagaaag accgagtagg gcatgggggt gggtgtgcaa 76020 ggggggtgtg tccggtgtgt gtgtgtggtg tatgttatgt gtgtggtgtg tgtccatatg 76080 tgtaatgtgt gttgtgtgtc aacgtgtgtt tgtcacgtgt ggtgtgtgtt gtgtgatatg 76140 tgatgtgtgt ctgggtgtgt gtggtatgtg tccgtgtgtg tgatgtgtgt ctgagtggta 76200 ttgtgtgtgg tatgtggtgt ctgtgtgttg tgtgtggtgt gtgtccgtgt gtggtgtgtg 76260 tggtgtctgt tgtgtgtgtg gtgtgttgtg tgtggtgtgt gtgtctgtgt gctgtgtgtt 76320 gtgtgtctgg gtgtgttgtg tgtccgtgtg tggtgcgtgt tgtgtctgtg tgtggtgtgt 76380 gttgcgtatg ttgtgtgtcc gtgtgtgtgt ggtgtgtgtc tgtgtgttgt gtggtgtgtc 76440 tgtggtgtgt ctgtgtgttg tgtgtccgtg tgtggtacgt gttgtgtctg tgtggtgtgt 76500 gttgcatatg ttgtgtgtct gtgtgtgctg tgtgtctgtg tagtgtgttg tgtggtctgt 76560 gtggtgtgtc tgtgtgttgt gtgtccatgt gtggtacgtg ttgtgtgttg tgtatgttgt 76620 gtgtcgatgt gtgtgttgtg tgtctgggtg tgtggtgtgt atgttatgtg tccgtgcacg 76680 tggtgcacgt gtgcatacgc ctgcatgtgt tcatttctgt gcgcatgtgt tgtgtgtgtg 76740 tccgggtgtg tccatttccg tgtgcctgta tggggccatg tgttatgccg agggctgacc 76800 atgggggggt cctgggctga ccaggtgagg ggtgagcccc accgccaccc ccttccacac 76860 ctgggtgagg gcagcagcag tgagggccct acccacccct cggtctcctc cagtccccca 76920 aggccctgat ggggctaagt ccatgcctcc ccagccctgg ccttgcagcc gctgctgacc 76980 cgccaggcag gcacgggtcc ttaaggttcg gcacctgcat gggtgccctg ggcactgccc 77040 tgactgccct gcaggacaca ctgggtcctg ggtgccaagg ctaggcaggc cctatgacac 77100 ggtgaccaca ggctcagctg gaggagcgtt tgctgatgca caggtggtta agggaagaac 77160 gggccacctt gggtcagctg tgcgtgaccc cgagcaacgt ggctgtgggt ggagtgggtg 77220 ccctcgagtc ccccagcccg aggggggccc cagagcagac ccagccacct ctgtgcagct 77280 gtgctgaggg ctcctgtctc ctgccccagg tatgtgaagg gctaccctcc caactcgccc 77340 tacatcggca gctccccaac cctgtgccac ctcctgcctg tgaaagcccc cttctgctgc 77400 ctgcggctgg acaaggtaag gctggcggct ctgccgcgct ctgcaccccc agacgccagc 77460 accgggccgt gcatacctgc cctggtttct ctttggtcac tttacatttc gataccattg 77520 caaacttcta gcacagctgc aagaattctg caagggagag ccacagatcc ttcacccaga 77580 ttcagcagac ggtcccttcc tgtcccgttt gggctctccc tctcacagtg tctatgttag 77640 aggcacctgt tttctgagcc atcttgagaa caggttggag ccaccacacc cctttcccct 77700 aatacatcta catgcgttcc caaagatcaa gaaccatctc gtaactacag ctcattagga 77760 cagggacccc ggcccggcat gggtgtctga tccacagtcc aagttcagat tgggccgagg 77820 gccccgaagg ccttcagcgt cctgcgtggc agtgttttcc ccaccgggag cctgtcccgg 77880 ctgcgtctta gcaactcctt tctcgttact ctcccttaat ctggaatgtt ccctggggtc 77940 tcttgacctt aatatttttg cagagcaggg accagtgacc tggtggcagg tgggtctgcg 78000 atgtttcttg gtggtgggac tctgcctgca tgtggggcca gccctccctg gaaactcggg 78060 ggtcaattgt caggtcactg gcgatgttta cttggatctc atggcaagct ggggtcagta 78120 gggtttcccc actgtgaaaa tgactgtttt ccttctggag ttagcagctt ctctgtgggg 78180 gacgtgttga gatcaggaaa gcaaaccact cgacccagcg gcttcaacat ccctcagtgg 78240 gttctttttt gtttatttgt tgtttggttt tttttaagac ggggtcccac tctgtcatcc 78300 aggctggagt gcagtggtgg gatcatagct cactacagcc tccacctccc aggctcaagg 78360 ggtcctccca cctcagcctc ccaagtggct gggaacacag gcacgcacca ccacacctgg 78420 ctaattttat ttatttattt attttttgta gtgatggggt ctcactatgt tgcccaggct 78480 agtctcgaac tcctggactc aagtgatcct cccacctcgg cctcccaaag tgctggggtt 78540 acaggcgtga gccaccatgc ctgccatctg tggatggttt ccagttccgg aatctctctc 78600 cagctgtgtg ttagggctcg gccacggagg ggacctcccc ttccccatgt gtgtgtgtcc 78660 ttcacggacc acaggctccc agcatattct gtgggttata atctgtggcc ggtcattgca 78720 gtagcatcat ccttgacaga tcgttattga ttctgatgct cggaccccct cagttcactg 78780 ggtggggtgg gggccttcaa gcggcttctg ggtgcttctg acacgatccc ctcacccttt 78840 gagctcatct gtgctttcca accggagatg ttccagccac atcttggcct tcgcctgctc 78900 cagtctggaa tgaaccactt ctccaaggaa ccctgattcc ttttagtgga aaatgatgat 78960 tggaaaccaa gacctgggca cgtggcgtgc tcactgctgt tggcatccct gctctgagaa 79020 aacgtgtgtg catacacat acacgtatct atgcccacac ctagatctct agccacatgc 79080 caaaaccaca tgttcacatg gacaccgccc tttccacccc tgacatgact gctctgtgcc 79140 gcctgtgggt acagctgtgg catctggtgg tgcctgtagc tccccacagg cgtgtgcagg 79200 ccgtgaaagg gctgtgggcc gagaggctaa cggctgggtg ttcacggggg atgtttggtg 79260 aggggtctgg gagggctcca gtggccagca ggaaccacag ccctgactcc agccctgact 79320 ccagcatctg cccccagggc tgcaagcaca acagctatga agacgccaag gcctacgggt 79380 tcaagaacaa gctgatcatc gtctcggcag agacggccgg caatgggctg tacaacttca 79440 tcgtgccact gcgggcctac tacagatccc gcaaggagct gaaccccatc gtgctgctgc 79500 tggacaacaa gtgaggctcc tggggctcag cccaccccgc ccacccgggc cctcagacct 79560 gcagccagca gcctccccaa ctgggcccac ccttcgcctt tgcagagggc acgggaacat 79620 ggggcctctg gcctggtcct ctcagctttc ctaaaaaggg ggactctcct tcctgctccc 79680 aactcctcct gctcccagct cctccccaca cccactcctg ctcccagctc ctccccaccc 79740 ccagctcctc tggctcctgg gtcctccctg ctccctgttc ccccagttcc cagctccacc 79800 caactcccag ctcctccttg cttccagctc ccccagttcc cagctactct ccattcccag 79860 ctcctcccca ctcccagctt ctccccactc ccagttcccc ctcactccca gctcctccct 79920 gctcccagtt cctctggcca ccagctcctc cccactccca gttcctctgt ctcccagctc 79980 ctccatgctc tcagctcctg tggctcccag ctcctcccac tctggtcctc tctccccctt 80040 tccccctcct cccttgtcac tccttctgtc ctgtttgcct cctgctccac tcactctgag 80100 ccccaggatt ggggtggagg gataaatggc tcttcctcct gggcaccttt ttgcccaggg 80160 gaccctagga ccctgacagc tgagcccagg gtcatcttgg ctgtgtgacc tcagcaggtc 80220 ccaccctccc gggccttggt ttccccttga ataaaataaa gaatggccca ctggccttaa 80280 agtactcccc aggtcccata cgctgcggtt ctggggaacc cctgcctggc ccagctctgt 80340 gcatggaggg tagggcccca ctgggcctga ggagggcagg ccttgaagca gggtgggccc 80400 ctccaggacc gctgtcccca caggcccgac caccacttcc tggaagccat ctgctgcttc 80460 cccatggtct actacatgga gggctctgtg gacaagtaag gcgtggccgg ccgaggctcg 80520 tgggggctcc acacccaccc ctcccctcct cttccaaagt ctggggtgac cccgaccgca 80580 ggtggggtgg ggggctgagg tcctcctgcc ttctgaccaa atcccggggt cctgtgggtg 80640 gggagtgggc cgcatcctca gccacgggcc ctcggtcccg ccaccagcct ggacagcctg 80700 ctgcagtgtg gcatcatcta tgcggacaac ctggtggtgg tggacaagga gagcaccatg 80760 agcgccgagg aggactacat ggcggacgcc aagaccatcg tcaacgtgca gaccatgttc 80820 cggtgcgtcc agtgtccggg gctcggctct aaaccacccc acagccacga ccacgggccc 80880 tcgccctgag acccccacag ccacgaccac gggccctcgc cctgagaccc ccacagccac 80940 gaccacgggc cctcgccctg agaccgccac agccacgacc acgggccctc gccctgagac 81000 ccccacagct atgaccacaa gccccccaccc tgaaaccccc acaaccacag ccatgggacc 81060 acaccctgag acccccacag ccatggactc tgcccagaga cccccacagc cacgaccaca 81120 agccctccac cctgagagtc ccacagccat gaccatgggc ctctgccctg agacccccca 81180 cagccgtggg accctgccct gagaccccca tagccaagac agtgggccct gccctgagac 81240 ccccccacag ccatgggacc ccgccctgag acccccacag ccacatgatc atgggccccc 81300 accctgagac ctcctacaac caccatgggc cccgccctga gccgcctgcc tcccccaggc 81360 tcttccccag cctcagcatc accacggagc tcacccaccc ttccaacatg cgcttcatgc 81420 agttccgcgc caaggacagc tactctctgg ctctttccaa actagaaaag gtgagcagcc 81480 ctgccccgtg ccagctgcca ccccagaatc ccagaaagag tgggagaaag gggctcaggg 81540 gaaagggggc cagtgccatg ggaggctggg ctcctgccgc cctcctgctg gggaactcag 81600 gagatggcgt ggggggccca gcatggacag ggtgctcttg atggtggaac caggagatgg 81660 aggcagggcg tttccctgac cgcgtgtgag gcactgggaa tgtggcccat agcagccttc 81720 catctccctg agcagggacc aggcctggcc gtatctggag gccaaggcca tctgtcctgg 81780 catggtcagt tggtcagaac tcccgtgggg agccctcaga tcggtggttc cacataggtt 81840 ggccagtagc tcttagtaca gataacgcac acggctgcac cattccagac ttctccgctg 81900 ccctggccac tacgcccgac cttgaaacag gttcagtata accactgcct ccttgtattg 81960 acaagggacg gagggcctga gagggaaggg gcctgccccg gatcgcacag tggagcaagt 82020 ggctgagctg gaattggctt tctgcccttg gagctccatg aagggcacca cccagggtca 82080 ggtgtggaac ccaggggcac gggcactgtt gctgttgcct tgatatctgg ctgaccccag 82140 ccccaccgca ttccccacct gctcaagctg ggacagcacc accttgtcca cacgggggct 82200 ggtgcccagg cagccctagg ctgagagcag ggagcaggca ccttggtcag cagcaatgct 82260 gtctgctcta cacgaacccc gagctcaccg gtctgggctg aagtcctcat cggcgagctg 82320 ctgggacctg cgtggctgca ggattgtgac accgtggagg atctactgag ccaggcccgg 82380 cctggccacc aacaccaggc agaggacaca cacgggcact ccctgcgaca cggacatggc 82440 tttgtcccac ctgaacccga tggagagtga aagtgtgttc cggccagccg tggaccaaga 82500 gcccataggg atcctggagt cagttctgcc ccagagaagc gagaggaggc cgggctgggc 82560 agccaccagg tcaacagggg cttctgcctt agagatgcca gcctgaggcg tagggggatg 82620 ctcgggcacc tggtctcagc acaggagagg gctctgtctg ccctgcccgc cgcccaagcc 82680 caccctggag cctgccctgc ccagcgtcgg gagctcctgg ccccagtccc cggctcagcc 82740 ggcagagggg tgtgctctgc agctggaacc acggaagggg aggaagttca caggattctg 82800 tgttcgggtg ccgggccgct ccccagggct gggaggactc tccggatctg gaagaccaag 82860 tctgaccctg tgtggacagg gatgctgccg tggagtcggg gtcgaggcag tcatcctggc 82920 gcggctcctc cggcctcagc cttgcacctc tctgtcccac aaggtggctt gaagtttggg 82980 tcagcaagca cgcagccaac acgctcctgc ccgccttccc gccaggcagc catcgccaat 83040 cacccacgct ccgccccgcc gtggggccca tctctttccc cggcttcacc tccactgggg 83100 ctctgtgttg ccggggcggg tgcggccagc tctccatctc agagcagtga acagtcctgg 83160 gctccagctc cagtcatgcg attccgtggc agttgtgtga cagggaccaa ggagaaatca 83220 ggacatcggc aaagcctctg gaagcagccg tgagctcctc tgggctgaca tggtgctggg 83280 gtccatgtgg gacagatgcc ctgggccctg ggcagggcca ggcatataca gagacgtgga 83340 gccgagggag gagagggtgc cgtggaccac ctgacccatc accctctgca gaggctggga 83400 tccgcctccc cagcatgcaa ggagcctgta gaaggcacca ggggctgcgt cttctccagc 83460 ctgggtggcc ttggccccag atcccccatg ggtctctctg acgggccagc atacggtgac 83520 ctgcttccaa caaggacacc tgtggcagct tcagatcctt atttaaaaga cattaatgcc 83580 aatttattat aaaaatgtac atgtttagta tgtattttac ttcaaagaat actgaaagta 83640 aaaaaaaaaa aaaattgaag aaaagttacc ccaaatccct gcagccaaca tcttctacat 83700 ccaggcccag tggaaggata aagacaggat tccaggcacg actccggaag gaaaaaggga 83760 ggaggtggag atggcataca cgaccgtcag tgagatgctc tgccaggtgc agcggctcat 83820 gcctgtaatc ccagcacttt tagaggctga agcaggaaga tcgcttgagg ccagaagttc 83880 gagaccagcc caggcaacat agcaagtccc catctataca aaaaatttaa tggctggggg 83940 cggtggctca tgcctgtaat cccagcactt tgggaggcta aggcggacgg atcacctgag 84000 gtcaggagtt cgagaccagg ctggccaaca tggagaaacc tctctactaa agacacaaaa 84060 attagccggg cgtggtggct gtaaccccag ctacttggga ggctagggca ggagaattgt 84120 ttgaacccgg gatgcagagg ttgcagtgag ccgagattgt gccactgcac tccaggctgg 84180 gcgacagagc gagaccctgt ctcaaaaaaa accaagcaaa aaaatgaaac tattattaag 84240 gatgctgctg gtggggtgac atgcatctcc ccttgagggc tggctccaga aggctctcag 84300 agccccggtg tgtgagagga gtctctcccc tgaggcccac ctcccctgcc gtccacctcc 84360 cctggtctcc agcacccagg actcctccac cacttcattg ctttcacatg gtcagcctgt 84420 gtgatctctc ctcctcacca ggagccttcc ttcaggctgg ctctgcccat cctggggctg 84480 cacggtgcct gtcctgctcc ctctgaccgg gggtctcgtg ctcaggaagg gctcatccgc 84540 tcctgtgtgc tcctgtcttc actgtcactt gtgaatggca cccgctcagc ccctgctgaa 84600 gccctcctgt ccagaaagca ggaggaaatc tctggaaggt cctgaaacgt ccagcttttt 84660 ctttccttcc acgtctctct ctggccctgt cgtggttctt gtttcctgtt tagcgttgtt 84720 ctgagtaaag gaaaattaaa attgcaagtt gttctggaat ttcacgttcg tctccgcgaa 84780 gtacggctgg aattctggat gcaaatcacc acgattgcaa actcacacgc ccatcgcagc 84840 tcatcgcacc tggttcttgc cccaagagcg gaaacgccgc acgaaactaa ttccactgtt 84900 tctcacgccc cagccttccc accggccact gatgagtaag ggcgaacccg gaggaaaagg 84960 ggcttctgcc tgcttgtcct gtcgctgtcg tgtcttttac ctgtgaatcg agttctggtt 85020 ccggggggaa gtgtggcctc cgtgggcgca cacgcctgcc tgtgcacact tgcttggagg 85080 ccgagctcca gggttggggc cctccgctga agaatgaccc gagagttggc cacggccggg 85140 tccggagccc gtggatgtac cgcctcacgt gacagaaggg cctctgcaga tgggattaag 85200 tcaggggcct cgagatggga gatcctcctg gagcatccgg caggttcacg ccgtcagggt 85260 ccttctaggg agaggccaga ggtccccatc cggtgggaag aagctgcacg gccagctcag 85320 aagagggaag agggagccac aagccaaggc aggtggcctc caggagctgg aaaaggcaag 85380 agaaggaggc ccccaggcct ccagagggag cggggccctg cccaggcctg gatccagcct 85440 gagacacctc aaactcccga ctccagaaac gggagagagg agacaggtgt cgttttagct 85500 gctaagtttg cggtcatttg ttacgggagc cccaggaaac tcagtgggtc cattgcaagc 85560 ctggagcaca gggacgggga ggccaaggac agcagggagc ccgatgcttg ctcctcctca 85620 gcccagactc cacacgccct ccggcaccac ttacaaaaca ccgggggagg agaggattat 85680 caggaggatt tggaatttcg ggatggcaag agcagggcgc ttgaccaagc gcagtgccca 85740 tggcagccgc cgggagtcca ccttctcatc agagccccac atcactcctc ccgggctctg 85800 gccctgagtg tgtctgggaa gatagagctg gttcaggcct gccggtgtat gcacacatgc 85860 agacacacac tgtgtacacg tggacacaca caccatgcac aaatgtgcac acaggtatca 85920 tgcacacatg tacggtgcac acacagtgcc ctcgaccccg tggctgccgt gccactggag 85980 ggacctcggc accagcccat ctgaggcccc tcctttccca cagagggagc gagagaatgg 86040 ctccaacctg gccttcatgt tccgcctgcc gttcgccgcc ggccgcgtct tcagcatcag 86100 catgttggac acactgctct accaggtcag cggggaagcg gcagcaggag ggtggcgcct 86160 gggtgggacc cccgtcatgc cctcagctct tcagcctggt ccctgttctg aatgatagga 86220 ctccctctga atgaccttcc ctggattcca aggagacctc tgggccctgt ccttgcccca 86280 gggatttctg ggcccttttt gacctatggg tgcctggcaa gggagttttc ttagaaaagg 86340 cctcccagaa ctctgcctgt gggtcatgtg gtgcttgggg acctggtggt tctgtgtgtg 86400 tgtatgcatg aggggtggcg agcccgtggc cggtggggta tggacctgtg tcccacgccc 86460 gtgcccgcgt gcctcactgt ggctccctcc ctccctccct ccctccctcc ctccctccct 86520 ccctccctgg ccagtccttc gtgaaggact acatgatcac catcacccgg ctgctgctgg 86580 gcctggacac cacgccgggc tcggggtacc tctgtgccgt aagtgcccct ggctgcgctg 86640 ggctgggggc gtgctgggct gtccaagtgg gtggatgggc acctgcccct gattcacggt 86700 ggccaggagg ctctgggtgc tgccacctgc cccagccaac tcagggttcc caccctgcag 86760 atgaaaatca ccgagggcga cctgtggatc cgcacgtacg gccgcctctt ccagaagctc 86820 tgctcctcca gcgccgagat ccccattggc atctaccgga cagagagcca cgtcttctcc 86880 acctcggagg ttctggggca gcctgggggc tgggactgtg gcagcccctg tcctgtgtga 86940 cccacagcat ccccaccttc cgggggctgg gactgtggca gcccctgtcc tgtgtgaccc 87000 acagcatccc caccttcagt gtcagggacc tgggctagat cagctttgct attgctggca 87060 gctccttccg tctggtccgt gtgcccacgt gtagcgcttc cagctggagc agccatgacc 87120 cctaccgggg gcagagaggc tcaggggagt cttcaggaag aatacgggca gcccctgtgc 87180 tgcagtccac acagcagcag gcaccgtgcc caccagccct aagcatgttc cgtgcagacc 87240 ccaggctgag gcggcgtggg gggcaggggt gcgcccacag gtcccagact gcgcctgttt 87300 cctttgcagc cccacgacct cagagcccag gtaagcaacc cctccgtgcc cacgcagctt 87360 ctgcggagca ccagaacatc gcagcttcac atggagaagc ctgccaggcc ccacccaccc 87420 acccacccac agggccctgg gaaagccgag gcaggagcgg gtccccacgga tgtgtcggcc 87480 ccagcacggc tcagagaagg ctgttgacac tcactccctc ctgcactggt ggtggggaag 87540 ctgaggcctg gggggagtag cctgtgagtt tggacaccag gtgcaccccc gccccctccc 87600 aggccccacc aaggcaggca gcccccatgc ccatctggcc tgaccagccc ccagcctccc 87660 aggcctttct gaaggtgcca cccaggtggg atgcctacct cttcccagca ccccacgacc 87720 cacaggctct ggcaccccac gttccccagg ttcggggcct ccaaagggtg tgtttgcaag 87780 agggatcagg gctcatctgc agatggagaa attgacacgc agagggggtg acctctcagg 87840 gcaaggccag gatgtgctgg ggtccagatg ggtcccaggc cggacccaca gaaataaggg 87900 ctcagagagg cgaagggagc tgccctcagc agcctggcga atcccttgac caggcccggg 87960 cagggtgggt ggcccggcga tctgtgctca ggaggaaacc aggcacattc tttccagagg 88020 aggaaggcac atgcaccctg gggtctgtcg tcgtcctctt ccctaacacc cccagctgct 88080 cccacgcagg ccccaagctg cagagcccac acctcttcct aagcccctgc cccaaagccc 88140 gcgaccctcc cggcagcctc acccctcccc gccctgccct gccctgccct gcccagtccc 88200 agatctcggt gaacgtggag gactgtgagg acacacggga agtgaagggg ccctggggct 88260 cccgcgctgg caccggaggc agctcccagg gccgccacac gggcggcggt gaccccgcag 88320 agcacccact gctacggcgc aagagcctgc agtgggcccg gaggctgagc cgcaaggcgc 88380 ccaagcaggc aggccgggcg gcggccgcgg agtggatcag ccagcagcgc ctcagcctgt 88440 accggcgctc tgagcgccag gagctctccg agctggtgaa gaaccgcatg aagcacctgg 88500 ggctgcccac caccggctac ggtaagggca cacggcgcgg gtgggggccg gacggacgga 88560 ctgggccagg gtcgggccac agccaagaac agtcggccac ggcgtcccgg ggcccgggcc 88620 gtcctcctgt ctgtcatctg tctgtctgtc agcctttctg gccaccctct gcctgcctct 88680 actgtggggc cagctgtggg caccaccacg gcccagcaga ggccccgtgc agaggaggga 88740 agtggccatg gcccaccctg gtgctgggag gccacaggac ccttgggcat ccctggtgtg 88800 agccccgtag ggaggtgctc gcttccactg ctctggggcc tcagtttccc tctctgccaa 88860 attagagaca ggagctggct gagccctttg gccaggggag gcagctgtgg ggtggagagg 88920 gccaggctgg gctccccaag tcgagggcat cagctagagt tgggccagcc agctgcagcc 88980 aggcctgctg gacagcggat acccagggtc cctgagttct cgcagagaac aagactggtg 89040 gggaccccct cccagagccc ccagccctcc cagcagccag ggtagggggg agactttggg 89100 ggaacagttg ggggaaaggc ccatgccagg acatgcctct gtccaccatg ggcctgttgc 89160 cactcccacg gcacagcccc ctcctgccgc ttcagggagc ccggcgtccg tcttcagcaa 89220 cagatccgtg cagccccctc tctctgcgcc ttgtggtggg aagtgtgctt gggcttcggg 89280 gccctacatg ccctgcctgg cgtggagaga agctcatccc ctccctcact ctagagatgc 89340 tacctccgtt gatgaagcca tgggccccag ctccccagca ccgggccgct acccagtgac 89400 acccacccct gagccgggtc gaggctccac cttccctttg ttccatctca gggacttgcc 89460 tgatgctcag ggctgcctct gtcccgtcgg agtgccccgt ctcccaaccc tgcttcctgc 89520 gtctgtcacc tgggtcgggg tcttgagtcc cctgagcaga gtcaggagct cacggctggc 89580 ccaggagctg ctcacgggtg actgggctgg gctggcctgc gggcccgaag gagactcaga 89640 ggccagggtt tggggaacag gtggcctgtg aagacctttc ccggccccca gccctgtggg 89700 cgctggggaa ggtgtccccc tgtccccgcc ttgaagcttc cctccatccc cacagtgtcc 89760 ctgtcccggg agggacttca cgccctttca ggtggggctc acgaggctga ggggggtgcc 89820 cagcattcat gtttgtggtc ccctgtgact gctggcagag gatgatcccg cccggtctgg 89880 ccacccccag agctggtgcc tgcctctgcg accgctgcct gcccccagag cttggcaagg 89940 aaggagcaac tgcctttctg gtgaccgact cgcttctggt ggccggcctc ccgtgcagct 90000 gcccctgcac ccgcccactg tgccggccgc ccgcacctcg cttgctgata ttctctctct 90060 ctctctttct gtctgtgcct ctttctgtgt gttctgtaga ggacgtagca aatttaacag 90120 ccagtgatgt catgaatcgg gtaaacctgg gatatttgca aggtaattct gccctggcgg 90180 gtgccgacca ccgcacaacg gggctcgcca acccttcacc gccggcagcc ttgctgcgcc 90240 atcccggcca ggcaggtgga caggagctgt gagagcacgt cccaggtgtc agcccaggcg 90300 gccctgttgg gcaaggcctc gcatgccgac agagtgtccc ctggctgggc gttgaggacg 90360 ggcctgaggc tgaggtctgg ggcttgtgct agtcaaggtg ctgttggccg ccaggcagag 90420 tggcgactgc ccagctctcg ggctcaccct ggtgctgctt ctcctgcttt gctgtttacg 90480 atgagctctg atgtgaccgg tgggccaccc tggcctacag ccagcccttc cctgtggccg 90540 gccccacaag cagtctgagg accctaagct cctctgctct caggaagcac ccagagggtc 90600 ccgagccagg gccccgggag gagctcggtg aagcctgggc tggatgcagg ggtggggact 90660 ccaagccacg aggagtaggc aggctttatg gctgcccagg ccaggtggat ggtgaccttc 90720 gtcccccagc tggggctcca cgaggggatt cttcctgctc ggctcgagca gagccgctcc 90780 acaccccgtt tcctccaaga acatgctgtg ccccgtcagt gctcagcaga gtccgggcca 90840 gggtgctccc aggggtcctg gcagcctcag gggagctcag agcctgcccc cgctgccaca 90900 cctccctaca gggtaaccca ggagcttgaa gggcctcctg agccaggacg ggtgttagct 90960 cgggagggac ctgtttgcca caatgccctt gcacccggag gcagggccag gcctggggca 91020 gccacagaag taaagcgtcg gcctctcccg gctctgtgct tttccccacg atggcgctca 91080 tggaagaccc tcgctctgcc gggcactgtg gtgctcggac ctgcagctag cggccttcat 91140 gagtgggatg cctgcgtcgc ccgctcccct cacccgccaa agcttcctgc ggctcccact 91200 gcagctccag ggcaggcatg gccacagcgg gcttgggggg cgagggctca caggactccc 91260 gcggcaggca tttcctgggc tcggcctaca tgcccgggag ggtgacggtg ccggggttct 91320 ggggctgggg agctgcaccc ccatgtttag attcaagcgg agcctaggcc aagaggcaga 91380 acaggaagag tcacaccctt tgcggggagg gcgggcagca tcctggggcc cctccagcgt 91440 gcagccccca tcccacacac acagcgggag gaggcacccc agccccgata ctcaccacaaa 91500 tcccctcttc acgccttcct cacagctgcc gtggggggag gcactagtta tccccagttt 91560 atagagaagg aaactgaggc tcgggtggcg gtagctctgg cctggcgtgg gggattcagg 91620 cgggagtgac cgtggatgcc aagagccagg aggtctggaa gcctctgggg cctgcagggt 91680 taggaagcgg gttggggggc gagcagagct accactgagg cctggagtaa aggtcggagg 91740 gtctgggtgg aggagtcagg tagccctggg gaccaggggc gaggtggccc tgccccagga 91800 catgcaccag aagagccaaa gccagcccct gccccacccc aggccctcag gcacacctgc 91860 tgccagcctt caccaagcac cgtggacacg cgaagctagt cctctgcgac catcctgggc 91920 agccaggacc agtgccatgt gactgaccac aacccaggcc ctggcactgc agctggggcc 91980 tggcatcccc acccgccccc tagcccagcc ccaagaaaca caaagcccag cctggctcag 92040 cccagtgagc tctgcttact tcagaagcgt gtggtccggg caccccagcg ggagaagctg 92100 gggcctgggg gccagtctgt gcctgccgga gtgaaatgag ctggtggccc cttgttctcg 92160 gtgtcccact gggtgctcgt cacaaagcca gtcaggcagg ggggcagggt cccaagaacc 92220 tactagagct gccctcacca cccactccct gtgccacctg ccatgcggcc accccagaag 92280 cgtgtgtggg cacgagggtg gggagggtgt gtctccctgc acagcctcag catgaggccc 92340 ctgggcctcc tccaaaggcc tggggaagac cccaccatgg gttttgggaa aagagcaaaa 92400 cagctgtgag gggcaggtgt caggccgtcc catcccgcag gtgtggacac aggagctggc 92460 accaaatgac ctgccgccgt gtgcgaaagg cctgaagcag agctggtctc ctggccggag 92520 ctgccctggt cgcccccaag tcctagcctg tgcccccgcc accctggcag cagctgtgct 92580 cacactgtgg gaactccaaa gcccccactg cagagggacc agcatggccc ccacctggct 92640 ggccagcagc ctccccgact tttcccttct cagggaccag ggcagggcta ccccaagggg 92700 agaggacggg cagagaggag ggaatggcag cagccagggt ggaggctccc tggggtcccc 92760 cgtcctgggt cacctttgtt ctctgtcctt ggagtcctgg aacaggaatc caggagcttc 92820 ccgtagacac catcagatgg ataaactgag gccacagacc ctttccagcc agtgaaccca 92880 gggccactgc tgggatggtg gcctctccct ccctgtgctt ggcagggcta ccctgccggc 92940 cccatggaga ctgtgagatg atggggggggc tgtctctcca ggaccgttct caccctgtgg 93000 gacacatgcc cacgcccacc ccatgagccg gacgccaggc tgtctcccat gaggggcaga 93060 ggccatgttc tcggagggat gagctgcggg gtgggggtgc tctgggctga tgccactcag 93120 gacttcagtc tgaagcaaag ggctgagcac agcgagtggg aatggcctgt ccaggcccgg 93180 ggacagcggc agctgcaggg ccctgaggga gggacagggc tgagcagcct ctggaggcgg 93240 gggtgggggt gtgtggatgt ggaggacggc atgcaggtgt gtatatgagt gagtgtgcag 93300 gggtctgtgg ataccatagg catgggttgc tatgaagatc tgtgcagaca cacaaatgtg 93360 tgtggaatac agaggtgaat ctgcaggtgt gtgcaggtgt agatgaaggc atgcatgcat 93420 gtgaggtgaa cagacacgtc ccggtgtctg caggctgacg tacgtggcag gtgtgcgctg 93480 gtgtgtgcag gtgtgctcag tgcctctgct cagggccacc cctttgctgc gatgccacct 93540 agcaccagag gtgggtgcgg gtcagagctg gctcccagct gccctcctgg ctgtcccctg 93600 ccctgtgtgg agatgggaca ggtgtcggtc agggatgggc cctggctggg ctcaccagga 93660 tgaggtgctg gagcagaatg gtcaggaagg ccggaaagac tcagctcatc ctggagcccc 93720 cacacctctg ggcccctgca gagctgggag gggcagggct gggggggtga cgtctgcccg 93780 gctgtgtcct ttgcagacga gatgaacgac caccagaaca ccctctccta cgtcctcatc 93840 aaccctccgc ccgacacgag gctggagccc agtgacattg tgtgagtagc acctgtgggc 93900 tgtgtggaga ccccccctga gcaccaggtg ggcactgggg agatgaggcc acaggcacca 93960 cagtggggcc gctcagcaga gggctgagca ggggctgccc ggcccacatc cactccaggg 94020 tcctctgtgc cctccgcag ctatctcatc cgctccgacc ccctggctca cgtggccagc 94080 agctcccaga gccggaagag cagctgcagc cacaagctgt cgtcctgcaa ccccgagact 94140 cgcgacgaga cacagctctg agccagccct gcacggagct caggccacca agcccggggt 94200 cctcaggaag gacgtggagg agcgtgtgag gacacggtgg cactagcgtg accctgggga 94260 tggcacactc tactcaccat ggctcctggg actccaccct ggaaaggagc ccctcatgcg 94320 gggggagggc cagctcaccc ctgggcacct gcaggctagt gaggagagtt ttttaaccta 94380 tttttacacg tcgatgcagt ccacttctct ttacacagat gtaccgcaac tcgtgaccag 94440 ggctggctgg gagggcaacg cagggactgg acgccctaca gggccgagcc caggctgtgc 94500 tggagggtgg ggctggggtg catggggagg ggagcagaac ccagaaccca ggagccccgc 94560 gtgggccaca cccaactcag agccggcctg agcgttcacg gccaggcagc ctcgcttcct 94620 tgcagccaag ggctgggggc cagggctgct gttctgcact ctggggtggg tgagggggac 94680 cctgggctgt ttgctgtccc aagccccttc tggaagttag aagcagcaaa gggcccgggg 94740 aagccgggca tgtgagaggg gtgcgtcccc aggtccccca gagggccctg tcgccgagga 94800 cctttctgaa ggaagcagaa gacgccattt cctctacttc acactgaact gtcccagcca 94860 ctgcatctag ggggcattgg gcggaagatg gtgcatttcc atggaccatt ttacacttac 94920 cttttaaagc aaagcctcat tttctaaacc cctgacttgt gaagcacaat tcagcctccg 94980 ggctgggcca cgtggagaga gaggatcttc tcagcaaggc gagatcccgg gcggcggctg 95040 acatcaggag cgccaccctg cgtcctttgc tgctggttcc ttactggttt gtacggtcag 95100 cgctggaaac ttctattaaa tggatgcatt ctggaggcat gaagttacaa gtcaagtcgc 95160 cctgctcgtg tttccaaggc tctcacccct cccagccacc ccactttaag ggttacaaac 95220 acctgctggg gtccccaccc caaccccata ggcaagcccc cattccccag ccaggccagg 95280 acagtccttc caaaactcgg gaaccaaatt gtatttggct actggtgact ggatcctggt 95340 agccaggaaa cctgcctggt ggtgggggtc ccagagtcca ggagggctgt ctggtgagct 95400 gcccatcagc ctcacccctg cagccaggca tgtccctggg gtgggcacag agaccccagg 95460 ctctgcccgc agtggcacag aactcatctg aggccagtgg ctgctgggga tcccctacac 95520 tgggggtcag ggctgcccca ggtggggatg tgtgtgcacc tcaccacgtt cacttcaggg 95580 taccccaaga ggctgaaggg gaaggaccaa aaggccgagg tgcagcccct ccccggtgtc 95640 agggcagaca acacagcagc tgctggaggg gccggccctg gccacacaga ctagctagtc 95700 ccttactccc ggcctgtctg gaaccctcct gctcagaagg tgcccactag ccctctgtgg 95760 gggacagagc cagacatggg tggtcaggga gaggctgtgt ggattcaggg gaccagaaag 95820 taagtcccag gaccttgatg gagcggcagg gattgatgtt gggctagggt ggccagagcc 95880 tgtcccagca gggctggggt ctatcacgtt cctgggatcc aagcagcgag cacgccctgc 95940 cccgcagtca ccccgccccg cagtcgccct gcagctggaa ggcccaagtc tgcctcacct 96000 gggtggcctc tcatgtcccc cacaccctgg cccccaggcg aggggggctg cacagcacct 96060 gcagggagga gaagggagag aaaagccggt ctggctgctg ggatgggagg gccacagttc 96120 cagcagtggc aggggaagct gtagcccctg gagccccaca ctggaagagc tggcctgcag 96180 gaggcaccat gggggagtcg catgacttat tcgggattga cttgcgatgt ggatggtgtt 96240 cccggagtcc cctgtggcca ctccaccacc atgaggccgg gaggcatctt agcctttgag 96300 cctctctcca ggggtgagcg gagcccccca aagagggctg aaggcttgct gcccaagagg 96360 ggctgggtga gcacttgggg cctctgagaa catcagtggt ccgttccctc ctgcacactg 96420 gtggcaagtg gcagcatttt ttcataatct ccagtaatga ggccacttcg ggtccagccc 96480 tggacatccg aggaggaggc gggcagtccc tgccccttca ctaaccgcag aggatgccag 96540 ctctaggccc cctgctccgc ctggagctca tgcgggcagc cgtggacaca ggtggcaccc 96600 agcgcccagc ggcctgtgaa tcctcccgtg ggcaaagctg ggagccaggg gctggaacca 96660 ggcaggtcag tgactgtgag atgccagctg ccagcccaag aaaagctgcc tgcagcatct 96720 ggaaacttct gtgctctcct tggcctctgt gttcttcatc tccaggttta gggagcaccc 96780 gggtgcctct ctgcttgtcc cgagcccact caccaacagc cccagcttgc acagtcatga 96840 catcaggaag gtgggtccct gctcccagcc gtcctcgtcc accatcactt ctcccagcct 96900 cgtgtcctgc tgacccataa aaggtccccc tgcaaagtac accaagtgaa gtaggatctg 96960 agcaaaggtt gagggactga attccctaag aagtcatcac tgcctagaat aagcgaaaag 97020 aatttttttt aatgttttac ggtagaatta tttgaaacat acaaaatgag tgagacacct 97080 gctattttcc ttattcctgt tttttgtttg tttttatttt ccttatacct aattcatcta 97140 acagaaaact gggcagggcg cagtgtctca cacctgtaat cccagcactt tgggaggcca 97200 aggcaggtgg actgcttgag cccaggagtt gagtttaaga tcagcgtggg caacatgatg 97260 aaccctgact gtatcaaaaa gtacaaaaaa aaaaatagct agacgtggtg gcatgtgcat 97320 acagtcccag gtacccaaga ggctgaggaa ggaggatcac ctgagctggg gaggttgagg 97380 ctgccgtgag ctgagatggc accactgcac tccagcctgg gtggcagaga gagaccctgt 97440 ctcaaacaaa acaaacaaac aaaaaagaaa aagaaaataa aactgtttgc tcaaaatcag 97500 aataccaaca gtgtattggg tgattatcgc ttatgtgtga gtgaaatgta agagcaacgt 97560 taaaagggac aggtgggagg aagcgggggc catcagttac aagttaccat gtgacctgag 97620 aagcagtaca gtgtaactta caggtggatc tggatgagct gcaaactcta gggcaaccac 97680 taaaatatat atatacttat ttttcttttt attatttttt tctatatatg gaagtataat 97740 tgatacgcta caaaagacaa gactatggaa tcatataaaa tgcttaactg aaaccagaga 97800 aagcagaaaa gaaaggcaga tagaaactaa gaccaagggc aacaaataga aaacagttac 97860 aaatatggta gatgataatc ccacgaaccc agtcatcaca ttcaatgtac atgaattagt 97920 ctaaatacac caattaaaat acagagactg gccgggcgcg gtggctcaca cctctaatcc 97980 cagcactctg ggaggccgag 98000 <210> 3 <211> 7123 <212> DNA <213> Homo sapiens <400> 3 agggcaacgc gagggaagaa ggtggcggct cccactcgct tctccctcgg gtcgggtccg 60 agctgccagg ccgcatgcca ctccctgacg gggcgcggac cccggggggc gtctgccggg 120 aggcgcgcgg cgggggctac accaaccgga ccttcgagtt tgacgacggc caatgcgccc 180 ccaggcggcc ctgcgcgggg gacggcgcgc tcctggacac cgccggcttc aagatgagcg 240 acctggactc cgaggtgctg cccttgccgc cgcgctaccg cttccgggac ctgctgctgg 300 gcgacccgtc cttccagaac gacgacaggg tccaggtgga gttctacgtc aacgagaaca 360 ccttcaagga gcggctcaag ctgttcttca tcaaaaacca aagatcgagc ctgaggatcc 420 ggctgttcaa cttctccctg aagctgctca cctgcctgct ctacattgtg cgcgtcctgc 480 tcgatgaccc ggccctgggc atcggatgct ggggctgccc aaagcagaac tactccttca 540 atgactcgtc ctccgagatc aactgggctc ctattctgtg ggtggagaga aagatgacac 600 tgtgggcgat ccaggtcatc gtggccataa taagcttcct ggagacgatg cttctcatct 660 acctcagcta caaaggcaac atctgggagc agatcttccg cgtgtccttc gtcctggaga 720 tgatcaacac tctgcccttc atcatcacga tcttctggcc gccgctgcgg aacctgttca 780 tccccgtctt tctgaactgc tggctggcca agcacgcgct ggaaaacatg attaatgact 840 tccaccgtgc catcctgcgg acacagtcag ccatgttcaa ccaggtcctc atcctcttct 900 gcaccctgct gtgcctcgtt ttcaggggga cctgcggcat ccagcacctg gagcgggcgg 960 gcgagaacct gtccctcctg acctccttct acttctgcat cgtcaccttc tccaccgtgg 1020 gctacggtga cgtcacgccc aagatctggc catcgcagct gctggtggtc atcatgatct 1080 gcgtggccct cgtggtgctc ccactgcagt tcgaggagct cgtctacctc tggatggagc 1140 ggcagaagtc aggggggcaac tacagccgcc accgtgcgca gacggagaag cacgtggtcc 1200 tgtgtgtcag ctccctcaag atcgaccttc tcatggactt cctgaacgag ttctacgccc 1260 acccccggct ccaggactat tacgtggtca tcctgtgccc cacggagatg gatgtccagg 1320 tgcgcagagt cctgcagatc cctctgtggt cccagcgggt catctacctc cagggctctg 1380 cactcaaaga ccaggacctc atgcgagcca agatggacaa tggggaggcc tgcttcatcc 1440 tcagcagcag gaacgaggtg gaccgcacgg ctgcagacca ccagaccatc ctgcgcgcct 1500 gggccgtgaa ggacttcgcc cccaactgcc ccctctacgt ccagatcctc aaacctgaaa 1560 acaagtttca cgtcaagttt gctgaccacg tggtgtgtga ggaggagtgc aagtacgcca 1620 tgctggcgct gaactgcatc tgcccggcga cctccaccct catcaccctg ctggtgcaca 1680 cgtcccgcgg ccaggaggga caggagtctc cggagcagtg gcagcgcatg tatgggcgct 1740 gctccggcaa cgaggtgtac cacatccgca tgggtgacag caagttcttc cgcgagtacg 1800 agggcaagag cttcacctac gcggccttcc acgcccacaa gaagtatggc gtgtgcctca 1860 tcgggctgaa gcgggaggac aacaagagca tcctgctgaa cccggggccc cggcacatcc 1920 tggccgcctc tgacacctgc ttctacatca acatcaccaa ggaggagaac tcggccttca 1980 tcttcaagca ggaggagaag cggaagaaga gggccttctc ggggcagggg ctgcacgagg 2040 gtccggcccg cctgcccgtg cacagcatca tcgcctccat ggggacagtg gccatggacc 2100 tgcagggcac agagcaccgg cctacgcaga gcggcggtgg gggcgggggc agcaagctgg 2160 cactgcccac ggagaacggc tcgggcagcc ggcggcccag catcgcgccc gtcctggaac 2220 tggccgacag ctcagccctg ctgccctgcg acctgctgag cgaccagtcg gaggatgagg 2280 tgacgccgtc ggacgacgag gggctctccg tggtagagta tgtgaagggc taccctccca 2340 actcgcccta catcggcagc tccccaaccc tgtgccacct cctgcctgtg aaagccccct 2400 tctgctgcct gcggctggac aagggctgca agcacaacag ctatgaagac gccaaggcct 2460 acgggttcaa gaacaagctg atcatcgtct cggcagagac ggccggcaat gggctgtaca 2520 acttcatcgt gccactgcgg gcctactaca gatcccgcaa ggagctgaac cccatcgtgc 2580 tgctgctgga caacaagccc gaccaccact tcctggaagc catctgctgc ttccccatgg 2640 tctactacat ggagggctct gtggacaacc tggacagcct gctgcagtgt ggcatcatct 2700 atgcggacaa cctggtggtg gtggacaagg agagcaccat gagcgccgag gaggactaca 2760 tggcggacgc caagaccatc gtcaacgtgc agaccatgtt ccggctcttc cccagcctca 2820 gcatcaccac ggagctcacc cacccttcca acatgcgctt catgcagttc cgcgccaagg 2880 acagctactc tctggctctt tccaaactag aaaagaggga gcgagagaat ggctccaacc 2940 tggccttcat gttccgcctg ccgttcgccg ccggccgcgt cttcagcatc agcatgttgg 3000 acacactgct ctaccagtcc ttcgtgaagg actacatgat caccatcacc cggctgctgc 3060 tgggcctgga caccacgccg ggctcggggt acctctgtgc catgaaaatc accgagggcg 3120 acctgtggat ccgcacgtac ggccgcctct tccagaagct ctgctcctcc agcgccgaga 3180 tccccattgg catctaccgg acagagagcc acgtcttctc cacctcggag ccccacgacc 3240 tcagagccca gtcccagatc tcggtgaacg tggaggactg tgaggacaca cgggaagtga 3300 aggggccctg gggctcccgc gctggcaccg gaggcagctc ccagggccgc cacacggggcg 3360 gcggtgaccc cgcagagcac ccactgctac ggcgcaagag cctgcagtgg gcccggaggc 3420 tgagccgcaa ggcgcccaag caggcaggcc gggcggcggc cgcggagtgg atcagccagc 3480 agcgcctcag cctgtaccgg cgctctgagc gccaggagct ctccgagctg gtgaagaacc 3540 gcatgaagca cctggggctg cccaccaccg gctacgacga gatgaacgac caccagaaca 3600 ccctctccta cgtcctcatc aaccctccgc ccgacacgag gctggagccc agtgacattg 3660 tctatctcat ccgctccgac cccctggctc acgtggccag cagctcccag agccggaaga 3720 gcagctgcag ccacaagctg tcgtcctgca accccgagac tcgcgacgag acacagctct 3780 gagccagccc tgcacggagc tcaggccacc aagcccgggg tcctcaggaa ggacgtggag 3840 gagcgtgtga ggacacggtg gcactagcgt gaccctgggg atggcacact ctactcacca 3900 tggctcctgg gactccaccc tggaaaggag cccctcatgc ggggggaggg ccagctcacc 3960 cctgggcacc tgcaggctag tgaggagagt tttttaacct atttttacac gtcgatgcag 4020 tccacttctc tttacacaca tgtaccgcaa ctcgtgacca gggctggctg ggagggcaac 4080 gcagggactg gacgccctac agggccgagc ccaggctgtg ctggagggtg gggctggggt 4140 gcatggggag gggagcagaa cccagaaccc aggagccccg cgtgggccac acccaactca 4200 gagccggcct gagcgttcac ggccaggcag cctcgcttcc ttgcagccaa gggctggggg 4260 ccagggctgc tgttctgcac tctggggtgg gtgaggggga ccctgggctg tttgctgtcc 4320 caagcccctt ctggaagtta gaagcagcaa agggcccggg gaagccgggc atgtgagagg 4380 ggtgcgtccc caggtccccc agagggccct gtcgccgagg acctttctga aggaagcaga 4440 agacgccatt tcctctactt cacactgaac tgtcccagcc actgcatcta gggggcattg 4500 ggcggaagat ggtgcatttc catggaccat tttacactta ccttttaaag caaagcctca 4560 ttttctaaac ccctgacttg tgaagcacaa ttcagcctcc gggctgggcc acgtggagag 4620 agaggatctt ctcagcaagg cgagatcccg ggcggcggct gacatcagga gcgccaccct 4680 gcgtcctttg ctgctggttc cttactggtt tgtacggtca gcgctggaaa cttctatta 4740 atggatgcat tctggaggca tgaagttaca agtcaagtcg ccctgctcgt gtttccaagg 4800 ctctcacccc tcccagccac cccactttaa gggttacaaa cacctgctgg ggtccccacc 4860 ccaaccccat aggcaagccc ccattcccca gccaggccag gacagtcctt ccaaaactcg 4920 ggaaccaaat tgtatttggc tactggtgac tggatcctgg tagccaggaa acctgcctgg 4980 tggtgggggt cccagagtcc aggagggctg tctggtgagc tgcccatcag cctcacccct 5040 gcagccaggc atgtccctgg ggtgggcaca gagaccccag gctctgcccg cagtggcaca 5100 gaactcatct gaggccagtg gctgctgggg atcccctaca ctgggggtca gggctgcccc 5160 aggtggggat gtgtgtgcac ctcaccacgt tcacttcagg gtaccccaag aggctgaagg 5220 ggaaggacca aaaggccgag gtgcagcccc tccccggtgt cagggcagac aacacagcag 5280 ctgctggagg ggccggccct ggccacacag actagctagt cccttactcc cggcctgtct 5340 ggaaccctcc tgctcagaag gtgcccacta gccctctgtg ggggacagag ccagacatgg 5400 gtggtcaggg agaggctgtg tggattcagg ggaccagaaa gtaagtccca ggaccttgat 5460 ggagcggcag ggattgatgt tgggctaggg tggccagagc ctgtcccagc agggctgggg 5520 tctatcacgt tcctgggatc caagcagcga gcacgccctg ccccgcagtc accccgcccc 5580 gcagtcgccc tgcagctgga aggcccaagt ctgcctcacc tgggtggcct ctcatgtccc 5640 ccacaccctg gcccccaggc gaggggggct gcacagcacc tgcagggagg agaagggaga 5700 gaaaagccgg tctggctgct gggatgggag ggccacagtt ccagcagtgg caggggaagc 5760 tgtagcccct ggagccccac actggaagag ctggcctgca ggaggcacca tgggggagtc 5820 gcatgactta ttcgggattg acttgcgatg tggatggtgt tcccggagtc ccctgtggcc 5880 actccaccac catgaggccg ggaggcatct tagcctttga gcctctctcc aggggtgagc 5940 ggagcccccc aaagagggct gaaggcttgc tgcccaagag gggctgggtg agcacttggg 6000 gcctctgaga acatcagtgg tccgttccct cctgcacact ggtggcaagt ggcagcattt 6060 tttcataatc tccagtaatg aggccacttc gggtccagcc ctggacatcc gaggaggagg 6120 cgggcagtcc ctgccccttc actaaccgca gaggatgcca gctctaggcc ccctgctccg 6180 cctggagctc atgcgggcag ccgtggacac aggtggcacc cagcgcccag cggcctgtga 6240 atcctcccgt gggcaaagct gggagccagg ggctggaacc aggcaggtca gtgactgtga 6300 gatgccagct gccagcccaa gaaaagctgc ctgcagcatc tggaaacttc tgtgctctcc 6360 ttggcctctg tgttcttcat ctccaggttt agggagcacc cgggtgcctc tctgcttgtc 6420 ccgagcccac tcaccaacag ccccagcttg cacagtcatg acatcaggaa ggtgggtccc 6480 tgctcccagc cgtcctcgtc caccatcact tctcccagcc tcgtgtcctg ctgacccata 6540 aaaggtcccc ctgcaaagta caccaagtga agtaggatct gagcaaaggt tgagggactg 6600 aattccctaa gaagtcatca ctgcctagaa taagcgaaaa gaattttttt taatgtttta 6660 cggtagaatt atttgaaaca tacaaaatga gtgagacacc tgctattttc cttattcctg 6720 ttttttgttt gtttttattt tccttatacc taattcatct aacagaaaac tgggcagggc 6780 gcagtgtctc acacctgtaa tcccagcact ttgggaggcc aaggcaggtg gactgcttga 6840 gcccaggagt tgagtttaag atcagcgtgg gcaacatgat gaaccctgac tgtatcaaaa 6900 agtacaaaaa aaaaaatagc tagacgtggt ggcatgtgca tacagtccca ggtacccaag 6960 aggctgagga aggaggatca cctgagctgg gggaggttgag gctgccgtga gctgagatgg 7020 caccactgca ctccagcctg ggtggcagag agagaccctg tctcaaacaa aacaaacaaa 7080 caaaaaagaa aaagaaaata aaactgtttg ctcaaaatca gaa 7123 <210> 4 <400> 4 000 <210> 5 <400> 5 000 <210> 6 <400> 6 000 <210> 7 <400> 7 000 <210> 8 <400> 8 000 <210> 9 <400> 9 000 <210> 10 <400> 10 000 <210> 11 <211> 19 <212> DNA <213> Artificial sequence <220> <223> Primer <400> 11 gtcaacgtgc agaccatgt 19 <210> 12 <211> 22 <212> DNA <213> Artificial sequence <220> <223> Primer <400> 12 tcgctccctc ttttctagtt tg 22 <210> 13 <211> 23 <212> DNA <213> Artificial sequence <220> <223> Probe <400> 13 agctcaccca cccttccaac atg 23 <210> 14 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Primer <400> 14 caggtggagt tctacgtcaa 20 <210> 15 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Primer <400> 15 gagaagttga acagccggat 20 <210> 16 <211> 24 <212> DNA <213> Artificial sequence <220> <223> Probe <400> 16 tgatgaagaa cagcttgagc cgct 24 <210> 17 <400> 17 000 <210> 18 <400> 18 000 <210> 19 <400> 19 000 <210> 20 <400> 20 000 <210> 21 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 21 agtgggagcc gccaccttct 20 <210> 22 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 22 ctggcagctc ggacccgacc 20 <210> 23 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 23 gtgtagcccc cgccgcgcgc 20 <210> 24 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 24 ggagcgcgcc gtccccccgcg 20 <210> 25 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 25 caggtcgctc atcttgaagc 20 <210> 26 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 26 cgtagaactc cacctggacc 20 <210> 27 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 27 ggacgcgcac aatgtagagc 20 <210> 28 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 28 tcgcccacag tgtcatcttt 20 <210> 29 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 29 tattatggcc acgatgacct 20 <210> 30 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 30 gttgatcatc tccaggacga 20 <210> 31 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 31 acaggttctc gcccgcccgc 20 <210> 32 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 32 ggccacgcag atcatgatga 20 <210> 33 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 33 tgccgctcca tccagaggta 20 <210> 34 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 34 cgttcaggaa gtccatgaga 20 <210> 35 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 35 gaagtccttc acggcccagg 20 <210> 36 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 36 cttcagcccg atgaggcaca 20 <210> 37 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 37 gccgagttct cctccttggt 20 <210> 38 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 38 caggacgggc gcgatgctgg 20 <210> 39 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 39 acctcatcct ccgactggtc 20 <210> 40 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 40 agcttgttct tgaacccgta 20 <210> 41 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 41 tctgccgaga cgatgatcag 20 <210> 42 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 42 gttgtacagc ccattgccgg 20 <210> 43 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 43 gtagtaggcc cgcagtggca 20 <210> 44 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 44 gatgctgaag acgcggccgg 20 <210> 45 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 45 cagaggtacc ccgagcccgg 20 <210> 46 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 46 tgcaggctct tgcgccgtag 20 <210> 47 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 47 tgctggctga tccactccgc 20 <210> 48 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 48 atgcggttct tcaccagctc 20 <210> 49 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 49 ccaccgtgtc ctcacacgct 20 <210> 50 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 50 gtagagtgtg ccatccccag 20 <210> 51 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 51 agccctggtc acgagttgcg 20 <210> 52 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 52 tgccccctag atgcagtggc 20 <210> 53 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 53 ccatcttccg cccaatgccc 20 <210> 54 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 54 ggaaatgcac catcttccgc 20 <210> 55 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 55 ccgtacaaac cagtaaggaa 20 <210> 56 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 56 gcgctgaccg tacaaaccag 20 <210> 57 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 57 ggtttacccg attcatgaca 20 <210> 58 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 58 acacagcacc tttagacggg 20 <210> 59 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 59 actgctccct aatatgggcc 20 <210> 60 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 60 aaatgaccaa ctcactggcg 20 <210> 61 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 61 cctggcatag ccagacacgg 20 <210> 62 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 62 tgccgtaccc tacacgctgg 20 <210> 63 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 63 acttcctgcc caatatcgga 20 <210> 64 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 64 ggagggtcct ccaagcggct 20 <210> 65 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 65 ttcacggccc ctaaaccacc 20 <210> 66 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 66 ggaggatttc ccacgacatc 20 <210> 67 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 67 ggccattgag ccaccaaggg 20 <210> 68 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 68 cattttaacc ctctttgccg 20 <210> 69 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 69 tcaatcccga acaccatgtc 20 <210> 70 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 70 ggtccgaaat cccaagcctg 20 <210> 71 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 71 gtgccggaat cctcaccctt 20 <210> 72 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 72 accgggcaca gatccccacct 20 <210> 73 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 73 tccgtgagat ccacactcca 20 <210> 74 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 74 ggcttctatc tcacacccgt 20 <210> 75 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 75 ccgtctgctc aaaccatcag 20 <210> 76 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 76 ggcggtaccc agggaccacc 20 <210> 77 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 77 ccagccttcg ccatcgccag 20 <210> 78 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 78 gcgcctggct attgggagct 20 <210> 79 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 79 acctgtgtct cggctgaggc 20 <210> 80 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 80 cgtctcggct gaggccccacg 20 <210> 81 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 81 caccatggcc atacccatcg 20 <210> 82 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 82 gcattgcact tatccagcgc 20 <210> 83 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 83 gtccacccca gacgatccac 20 <210> 84 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 84 atggtccatc ccagaaggtc 20 <210> 85 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 85 agagggtcca ccatggatgg 20 <210> 86 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 86 ggtccaccca agagggtcca 20 <210> 87 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 87 tgtgcaggct gacagcgggt 20 <210> 88 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 88 tcctgcccca gacgcaccgt 20 <210> 89 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 89 gtgtgcacac gcgccctgcc 20 <210> 90 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 90 tcaggtaccg ccgctcaccc 20 <210> 91 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 91 gggctcttac ccacatactt 20 <210> 92 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 92 cgccagcctt accttgtcca 20 <210> 93 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 93 agctgtaccc acaggcggca 20 <210> 94 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 94 ccgagcatcc ccctacgcct 20 <210> 95 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 95 gttcgccctt actcatcagt 20 <210> 96 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 96 cacaggtcca taccccaccg 20 <210> 97 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 97 tccgagcacc acagtgcccg 20 <210> 98 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 98 tgcccggacc acacgcttct 20 <210> 99 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 99 cgagtgggag ccgccacctt 20 <210> 100 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 100 gcgccccgtc agggagtggc 20 <210> 101 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 101 tggtgtagcc cccgccgcgc 20 <210> 102 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 102 gtccaggagc gcgccgtccc 20 <210> 103 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 103 tcggagtcca ggtcgctcat 20 <210> 104 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 104 agccgctcct tgaaggtgtt 20 <210> 105 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 105 cgagcaggac gcgcacaatg 20 <210> 106 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 106 atcgcccaca gtgtcatctt 20 <210> 107 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 107 acacgcggaa gatctgctcc 20 <210> 108 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 108 gaacaggttc cgcagcggcg 20 <210> 109 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 109 ggacaggttc tcgcccgccc 20 <210> 110 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 110 cacgagggcc acgcagatca 20 <210> 111 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 111 gctgtagttg ccccctgact 20 <210> 112 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 112 tggacatcca tctccgtggg 20 <210> 113 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 113 gggcgaagtc cttcacggcc 20 <210> 114 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 114 cgcttcagcc cgatgaggca 20 <210> 115 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 115 ggccgagttc tcctccttgg 20 <210> 116 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 116 cggccagttc caggacgggc 20 <210> 117 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 117 cgtcacctca tcctccgact 20 <210> 118 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 118 cgagacgatg atcagcttgt 20 <210> 119 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 119 ctctgccgag acgatgatca 20 <210> 120 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 120 agttgtacag cccattgccg 20 <210> 121 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 121 cttgcgggat ctgtagtagg 20 <210> 122 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 122 gtagtccttc acgaaggact 20 <210> 123 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 123 acagaggtac cccgagcccg 20 <210> 124 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 124 ttgcggctca gcctccgggc 20 <210> 125 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 125 ctgctggctg atccactccg 20 <210> 126 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 126 catgcggttc ttcaccagct 20 <210> 127 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 127 tagtgccacc gtgtcctcac 20 <210> 128 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 128 gagtagagtg tgccatcccc 20 <210> 129 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 129 gacgcacccc tctcacatgc 20 <210> 130 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 130 aatgccccct agatgcagtg 20 <210> 131 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 131 caccatcttc cgcccaatgc 20 <210> 132 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 132 ccggaggctg aattgtgctt 20 <210> 133 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 133 accgtacaaa ccagtaagga 20 <210> 134 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 134 ccgattcatg acatcactgg 20 <210> 135 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 135 aggtttaccc gattcatgac 20 <210> 136 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 136 cccagcttct taccaggtcg 20 <210> 137 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 137 gggtacacga tacccgttca 20 <210> 138 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 138 gcaccgggcc ttatctgatc 20 <210> 139 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 139 gcacacggcc ataagcaggt 20 <210> 140 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 140 ctgccgtacc ctacacgctg 20 <210> 141 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 141 gcacagcacg ccaagaccgc 20 <210> 142 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 142 cggcacttcc accttaccca 20 <210> 143 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 143 tcctcgaacc ttcacggccc 20 <210> 144 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 144 tcggagagcc acgcccgtca 20 <210> 145 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 145 acaggaatct ttcgaaggcc 20 <210> 146 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 146 ccctccaaac aattatgcga 20 <210> 147 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 147 acagttcaat cccgaacacc 20 <210> 148 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 148 ctaggactat tatacccagc 20 <210> 149 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 149 tcgctttgcc taccgcgagc 20 <210> 150 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 150 ccggctcaaa ccaccgccag 20 <210> 151 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 151 cggcaggttc ccacacgcaa 20 <210> 152 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 152 ggcacggctt ctatctcaca 20 <210> 153 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 153 ccctttacct ccccgtggac 20 <210> 154 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 154 gcttgtcacc ccaccgggca 20 <210> 155 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 155 gccccacctt acaggtgcct 20 <210> 156 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 156 gagtggagac tcatcccacc 20 <210> 157 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 157 cacctgtgtc tcggctgagg 20 <210> 158 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 158 agtggtgacc aggcctcgct 20 <210> 159 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 159 gccccaccctt accatcgcca 20 <210> 160 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 160 gtcaggagcc tatgtctggg 20 <210> 161 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 161 tggtccaccc cagacgatcc 20 <210> 162 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 162 caccctggat ggtccaccct 20 <210> 163 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 163 aagagggtcc accatggatg 20 <210> 164 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 164 cccagacgat ccaccccaga 20 <210> 165 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 165 caccggtattc ccagtgcccc 20 <210> 166 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 166 cagacgcacc gtcacccacg 20 <210> 167 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 167 cgtgtgcaca cgcgccctgc 20 <210> 168 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 168 ggcacacgcc atacctgggc 20 <210> 169 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 169 cccccatgcc ctactcggtc 20 <210> 170 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 170 ggtgcctcta acatagacac 20 <210> 171 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 171 acagctgtac ccacaggcgg 20 <210> 172 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 172 cgtctctgta tatgcctggc 20 <210> 173 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 173 cgggttcgcc cttactcatc 20 <210> 174 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 174 gctgcccgta ttcttcctga 20 <210> 175 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 175 cgcaggcatc ccactcatga 20 <210> 176 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 176 tccggccttc ctgaccattc 20 <210> 177 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 177 ctggaggtag atgacccgct 20 <210> 178 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 178 cggacccgac ccgagggaga 20 <210> 179 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 179 ccgcgccccg tcagggagtg 20 <210> 180 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 180 gttggtgtag cccccgccgc 20 <210> 181 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 181 gccggcggtg tccaggagcg 20 <210> 182 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 182 acctcggagt ccaggtcgct 20 <210> 183 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 183 gagccgctcc ttgaaggtgt 20 <210> 184 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 184 ggagtagttc tgctttgggc 20 <210> 185 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 185 tggatcgccc acagtgtcat 20 <210> 186 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 186 cgaaggacac gcggaagatc 20 <210> 187 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 187 tgaacaggtt ccgcagcggc 20 <210> 188 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 188 gtcaccgtag cccacggtgg 20 <210> 189 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 189 gacgagctcc tcgaactgca 20 <210> 190 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 190 gtgcttctcc gtctgcgcac 20 <210> 191 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 191 atgcgctgcc actgctccgg 20 <210> 192 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 192 ccgcttcagc ccgatgaggc 20 <210> 193 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 193 gagccgttct ccgtgggcag 20 <210> 194 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 194 tcggccagtt ccaggacggg 20 <210> 195 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 195 gagggtagcc cttcacatac 20 <210> 196 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 196 ccgagacgat gatcagcttg 20 <210> 197 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 197 gccgtctctg ccgagacgat 20 <210> 198 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 198 aagttgtaca gcccattgcc 20 <210> 199 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 199 ttcagctcct tgcgggatct 20 <210> 200 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 200 tgtagtcctt cacgaaggac 20 <210> 201 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 201 acaggtcgcc ctcggtgatt 20 <210> 202 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 202 ccggcctgcc tgcttgggcg 20 <210> 203 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 203 gcgccggtac aggctgaggc 20 <210> 204 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 204 ccaggtgctt catgcggttc 20 <210> 205 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 205 cgctagtgcc accgtgtcct 20 <210> 206 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 206 ggccctcccc ccgcatgagg 20 <210> 207 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 207 ggacgcaccc ctctcacatg 20 <210> 208 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 208 gcccaatgcc ccctagatgc 20 <210> 209 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 209 gcaccatctt ccgcccaatg 20 <210> 210 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 210 cgggatctcg ccttgctgag 20 <210> 211 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 211 gaccgtacaa accagtaagg 20 <210> 212 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 212 tacccgattc atgacatcac 20 <210> 213 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 213 caggtttacc cgattcatga 20 <210> 214 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 214 cccttaaaga ccatccgccc 20 <210> 215 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 215 ctggcgggcc ccacacatcc 20 <210> 216 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 216 atggattttc atcacggcct 20 <210> 217 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 217 gcgcaccact cctccctgat 20 <210> 218 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 218 cctgccgtac cctacacgct 20 <210> 219 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 219 cggcacacaa cccatgtgcc 20 <210> 220 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 220 agcggcactt ccaccttacc 20 <210> 221 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 221 cccgactcct cctcgaacct 20 <210> 222 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 222 gtggcattcc atgttgaccc 20 <210> 223 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 223 accgtgtttc tacataagcc 20 <210> 224 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 224 gctgttacat ccgcagtgag 20 <210> 225 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 225 ccgtgtatac ctgtctcccc 20 <210> 226 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 226 acaacaagat ccaggcaccg 20 <210> 227 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 227 ggaaggacaa taccttcggc 20 <210> 228 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 228 tgcccggctc aaaccaccgc 20 <210> 229 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 229 cgcagcatcc aaacccacgg 20 <210> 230 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 230 cggcacacac tatagcctcg 20 <210> 231 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 231 tccgccctga ccatcgcccc 20 <210> 232 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 232 ggctcctatc aatcgaatct 20 <210> 233 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 233 ggacccttct ccctacgctg 20 <210> 234 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 234 tgggttccct acttactgag 20 <210> 235 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 235 acacctgtgt ctcggctgag 20 <210> 236 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 236 gccaggtccc agatgctatc 20 <210> 237 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 237 gcagcccacc cttaccatcg 20 <210> 238 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 238 ccggtcttcc aggcactcgc 20 <210> 239 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 239 atggtccacc ccagacgatc 20 <210> 240 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 240 atggtccacc ccagatggtc 20 <210> 241 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 241 caagagggtc caccatggat 20 <210> 242 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 242 ccggacagtc taccccagac 20 <210> 243 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 243 ccaccggtat cccagtgccc 20 <210> 244 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 244 ccagacgcac cgtcacccac 20 <210> 245 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 245 acacagctcg cctaactgcg 20 <210> 246 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 246 gggcagagtg cctactgcgc 20 <210> 247 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 247 cctcggcata acacatggcc 20 <210> 248 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 248 gatcagacac ccatgccggg 20 <210> 249 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 249 tcggccggcc acgccttact 20 <210> 250 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 250 gactcctctc acacaccggg 20 <210> 251 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 251 tccgggttcg cccttactca 20 <210> 252 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 252 gtgaagctgc gatgttctgg 20 <210> 253 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 253 acccgcttcc taaccctgca 20 <210> 254 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 254 gagttctgtg ccactgcggg 20 <210> 255 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 255 tcggacccga cccgagggag 20 <210> 256 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 256 tccgcgcccc gtcagggagt 20 <210> 257 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 257 caaactcgaa ggtccggttg 20 <210> 258 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 258 tcgctcatct tgaagccggc 20 <210> 259 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 259 cacctcggag tccaggtcgc 20 <210> 260 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 260 acagcttgag ccgctccttg 20 <210> 261 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 261 gacgagtcat tgaaggagta 20 <210> 262 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 262 ctggatcgcc cacagtgtca 20 <210> 263 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 263 ccaggacgaa ggacacgcgg 20 <210> 264 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 264 ccccgtgaaa acgaggcaca 20 <210> 265 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 265 cgatggccag atcttgggcg 20 <210> 266 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 266 agacgagctc ctcgaactgc 20 <210> 267 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 267 cgtgcttctc cgtctgcgca 20 <210> 268 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 268 ttcacggccc aggcgcgcag 20 <210> 269 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 269 ttgctgtcac ccatgcggat 20 <210> 270 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 270 ccccgggttc agcaggatgc 20 <210> 271 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 271 cgagccgttc tccgtgggca 20 <210> 272 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 272 tgtcggccag ttccaggacg 20 <210> 273 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 273 ggagggtagc ccttcacata 20 <210> 274 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 274 gccgagacga tgatcagctt 20 <210> 275 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 275 cggccgtctc tgccgagacg 20 <210> 276 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 276 cacgatgaag ttgtacagcc 20 <210> 277 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 277 gtccgcatag atgatgccac 20 <210> 278 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 278 atgtagtcct tcacgaagga 20 <210> 279 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 279 cggatccaca ggtcgccctc 20 <210> 280 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 280 ggctgatcca ctccgcggcc 20 <210> 281 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 281 cggttcttca ccagctcgga 20 <210> 282 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 282 gggtcggagc ggatgagata 20 <210> 283 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 283 gtcacgctag tgccaccgtg 20 <210> 284 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 284 tggccctccc cccgcatgag 20 <210> 285 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 285 gggacgcacc cctctcacat 20 <210> 286 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 286 ccgcccaatg ccccctagat 20 <210> 287 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 287 tgcaccatct tccgcccaat 20 <210> 288 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 288 ccgggatctc gccttgctga 20 <210> 289 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 289 ctgaccgtac aaaccagtaa 20 <210> 290 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 290 ttacccgatt catgacatca 20 <210> 291 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 291 ccaggtttac ccgattcatg 20 <210> 292 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 292 ggttctgacc acgctgttgc 20 <210> 293 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 293 aagatgccca tttaaccggg 20 <210> 294 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 294 aacttggaac ctctacctgg 20 <210> 295 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 295 cctccgcgcc ccaagtcggg 20 <210> 296 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 296 cctgaccatt ttcaacctcg 20 <210> 297 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 297 tgtcctatag acaccaacac 20 <210> 298 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 298 acgaagcttc ctcttgcctg 20 <210> 299 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 299 gacaccgttc acatgtgatg 20 <210> 300 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 300 ccttcgggag ccacacgctc 20 <210> 301 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 301 gggtacggcc tcatccaggt 20 <210> 302 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 302 ggtggctgtt acatccgcag 20 <210> 303 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 303 gtaacgaacc accaccagcc 20 <210> 304 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 304 agccccacacg ccatacagtt 20 <210> 305 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 305 ctgcagggcc cttcaccgcg 20 <210> 306 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 306 cccgcgcgcc cctacctctg 20 <210> 307 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 307 cccgatatag ccctagctga 20 <210> 308 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 308 gccccgtccc tacacggctg 20 <210> 309 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 309 ggccactcct cctaggcggg 20 <210> 310 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 310 agtcggctgc cttagccctc 20 <210> 311 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 311 agggtacat ccacatctgc 20 <210> 312 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 312 acctggtttt cccccacgga 20 <210> 313 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 313 cacacctgtg tctcggctga 20 <210> 314 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 314 cggcacagcc agacaagcgc 20 <210> 315 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 315 cggaggatac atatctgctg 20 <210> 316 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 316 gggacttgcc aagcagtcct 20 <210> 317 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 317 ctgaatggtc caccccagac 20 <210> 318 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 318 atccaccctg gatggtccac 20 <210> 319 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 319 cacccaagag ggtccaccat 20 <210> 320 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 320 ggaactctac cttcagcccg 20 <210> 321 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 321 cagatacacc atcacccacg 20 <210> 322 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 322 gccccagacg caccgtcacc 20 <210> 323 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 323 ggtggacctt ccatcgctcc 20 <210> 324 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 324 ggttggctga ttctgggctc 20 <210> 325 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 325 ggacttagcc ccatcagggc 20 <210> 326 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 326 gtgacctgac aattgacccc 20 <210> 327 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 327 gaccaactga ccatgccagg 20 <210> 328 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 328 cggatgagcc cttcctgagc 20 <210> 329 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 329 gggtcattct tcagcggagg 20 <210> 330 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 330 gtgtgccctt accgtagccg 20 <210> 331 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 331 aacccgcttc ctaaccctgc 20 <210> 332 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 332 tgcgactccc ccatggtgcc 20 <210> 333 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 333 agctcggacc cgacccgagg 20 <210> 334 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 334 gtccgcgccc cgtcagggag 20 <210> 335 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 335 cgtcaaactc gaaggtccgg 20 <210> 336 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 336 gtcgctcatc ttgaagccgg 20 <210> 337 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 337 tagaactcca cctggaccct 20 <210> 338 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 338 gagaagttga acagccggat 20 <210> 339 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 339 ggaggacgag tcattgaagg 20 <210> 340 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 340 acctggatcg cccacagtgt 20 <210> 341 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 341 gatcatctcc aggacgaagg 20 <210> 342 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 342 gtgctggatg ccgcaggtcc 20 <210> 343 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 343 cacgcagatc atgatgacca 20 <210> 344 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 344 ccagaggtag acgagctcct 20 <210> 345 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 345 aaggtcgatc ttgagggagc 20 <210> 346 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 346 ccttcacggc ccaggcgcgc 20 <210> 347 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 347 tcgcggaaga acttgctgtc 20 <210> 348 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 348 cgagttctcc tccttggtga 20 <210> 349 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 349 cgccggctgc ccgagccgtt 20 <210> 350 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 350 agctgtcggc cagttccagg 20 <210> 351 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 351 ttcttgaacc cgtaggcctt 20 <210> 352 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 352 tgccgagacg atgatcagct 20 <210> 353 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 353 ttgccggccg tctctgccga 20 <210> 354 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 354 cagtggcacg atgaagttgt 20 <210> 355 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 355 ccaggttgtc cgcatagatg 20 <210> 356 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 356 tcatgtagtc cttcacgaag 20 <210> 357 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 357 gtgcggatcc acaggtcgcc 20 <210> 358 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 358 tggctgatcc actccgcggc 20 <210> 359 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 359 gcggttcttc accagctcgg 20 <210> 360 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 360 ttgcaggacg acagcttgtg 20 <210> 361 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 361 ccagggtcac gctagtgcca 20 <210> 362 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 362 gttgcggtac atctgtgtaa 20 <210> 363 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 363 ccttcagaaa ggtcctcggc 20 <210> 364 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 364 atcttccgcc caatgccccc 20 <210> 365 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 365 atgcaccatc ttccgcccaa 20 <210> 366 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 366 gcccgggatc tcgccttgct 20 <210> 367 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 367 gctgaccgta caaaccagta 20 <210> 368 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 368 tttacccgat tcatgacatc 20 <210> 369 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 369 ccccagatcg ccagcccgtc 20 <210> 370 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 370 gcaccaagac ctatggactc 20 <210> 371 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 371 ggcgacggtg ccaaggagga 20 <210> 372 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 372 gagcgcatca ctattttctc 20 <210> 373 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 373 tgggctcatc ctgttggtcc 20 <210> 374 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 374 tagaatattc cattccccgc 20 <210> 375 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 375 ctcatcctat agacaccaac 20 <210> 376 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 376 acttccccga ccagctgaga 20 <210> 377 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 377 gcgggattcg ccctctcagg 20 <210> 378 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 378 ccctcgccga ccactggcct 20 <210> 379 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 379 caggttctac ctaccaaggg 20 <210> 380 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 380 atcaccataa ccagacccgg 20 <210> 381 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 381 tgcaacattt tcaagcctcg 20 <210> 382 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 382 gcaatggaag ccacactcga 20 <210> 383 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 383 gcgctcccga tacctgccct 20 <210> 384 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 384 ttgaccttag cctcaaccgc 20 <210> 385 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 385 tcggcctacg ccaggctctc 20 <210> 386 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 386 gggcgcagcc acacactcgc 20 <210> 387 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 387 gggtgacttc ccaactggct 20 <210> 388 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 388 tggctcacct accgtggcca 20 <210> 389 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 389 gggctaaccc ccacatcaga 20 <210> 390 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 390 ctgtgaggtg ccatccccggg 20 <210> 391 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 391 tctcggctga ggcccagggg 20 <210> 392 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 392 ggtgagattt acggattggg 20 <210> 393 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 393 acaatctccc ccaaagcggc 20 <210> 394 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 394 cccggacgat ccaccctgga 20 <210> 395 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 395 cctgaatggt ccaccccaga 20 <210> 396 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 396 caccctagac aatccaccct 20 <210> 397 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 397 tccacccaag agggtccacc 20 <210> 398 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 398 atggcctacg cccttgccct 20 <210> 399 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 399 tgccccagac gcaccgtcac 20 <210> 400 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 400 acgcgccctg ccccagacgc 20 <210> 401 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 401 gacctcaacc ccctacttgg 20 <210> 402 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 402 cggcgagttc ccagagctca 20 <210> 403 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 403 ccgttcttcc cttaaccacc 20 <210> 404 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 404 ccggccacag attataaccc 20 <210> 405 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 405 ggagttctga ccaactgacc 20 <210> 406 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 406 gcatccagaa ttccagccgt 20 <210> 407 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 407 gctcgccacc cctcatgcat 20 <210> 408 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 408 gccgtgtgcc cttaccgtag 20 <210> 409 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 409 tgctcgcccc ccaacccgct 20 <210> 410 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 410 gggaggattc acaggccgct 20 <210> 411 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 411 cagctcggac ccgacccgag 20 <210> 412 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 412 gtagccccccg ccgcgcgcct 20 <210> 413 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 413 gcgcgccgtc ccccgcgcag 20 <210> 414 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 414 aggtcgctca tcttgaagcc 20 <210> 415 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 415 gtagaactcc acctggaccc 20 <210> 416 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 416 gacgcgcaca atgtagagca 20 <210> 417 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 417 ccagttgatc tcggaggacg 20 <210> 418 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 418 ttatggccac gatgacctgg 20 <210> 419 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 419 ttgatcatct ccaggacgaa 20 <210> 420 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 420 ttctcgcccg cccgctccag 20 <210> 421 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 421 ccacgcagat catgatgacc 20 <210> 422 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 422 ccgctccatc cagaggtaga 20 <210> 423 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 423 tgagaaggtc gatcttgagg 20 <210> 424 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 424 tccttcacgg cccaggcgcg 20 <210> 425 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 425 actcgcggaa gaacttgctg 20 <210> 426 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 426 ccgagttctc ctccttggtg 20 <210> 427 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 427 ccgccggctg cccgagccgt 20 <210> 428 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 428 cctcatcctc cgactggtcg 20 <210> 429 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 429 gttcttgaac ccgtaggcct 20 <210> 430 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 430 ctgccgagac gatgatcagc 20 <210> 431 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 431 ttgtacagcc cattgccggc 20 <210> 432 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 432 gcagtggcac gatgaagttg 20 <210> 433 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 433 cggcggcgaa cggcaggcgg 20 <210> 434 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 434 cagccgggtg atggtgatca 20 <210> 435 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 435 cgtgcggatc cacaggtcgc 20 <210> 436 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 436 gctggctgat ccactccgcg 20 <210> 437 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 437 tgcggttctt caccagctcg 20 <210> 438 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 438 accgtgtcct cacacgctcc 20 <210> 439 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 439 ccccagggtc acgctagtgc 20 <210> 440 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 440 agttgcggta catctgtgta 20 <210> 441 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 441 ggacagttca gtgtgaagta 20 <210> 442 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 442 catcttccgc ccaatgcccc 20 <210> 443 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 443 gaaatgcacc atcttccgcc 20 <210> 444 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 444 agccgccgcc cgggatctcg 20 <210> 445 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 445 cgctgaccgt acaaaccagt 20 <210> 446 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 446 gtttacccga ttcatgacat 20 <210> 447 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 447 ggagaactgc gatttctgtc 20 <210> 448 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 448 cccctctgaa ccatagcacc 20 <210> 449 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 449 aatgaccaac tcactggcgc 20 <210> 450 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 450 cgcgggagcc ccaaacccac 20 <210> 451 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 451 agcggatgaa ttattcccat 20 <210> 452 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 452 gtagaatatt ccattccccg 20 <210> 453 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 453 tgtcccatcc tatagacacc 20 <210> 454 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 454 cactcacgcc ttcacgcaga 20 <210> 455 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 455 tggtggcttc ctgacgcgga 20 <210> 456 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 456 cagactggcc acgcccctcg 20 <210> 457 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 457 cactcgcctt tttagagccc 20 <210> 458 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 458 tctcagattc acaatcccgg 20 <210> 459 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 459 ccccctcgcc acgcatggtt 20 <210> 460 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 460 gccggaatcc tcacccttag 20 <210> 461 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 461 ccggcccgcc ccaaactcac 20 <210> 462 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 462 cgtgagatcc acactccaga 20 <210> 463 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 463 ggtgacaacc acactcgagg 20 <210> 464 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 464 gggaacatcg ccattcccag 20 <210> 465 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 465 ccaccgggcc ctaaaagcat 20 <210> 466 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 466 ttcgccatcg ccaggcttgc 20 <210> 467 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 467 cgcctggcta ttgggagctg 20 <210> 468 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 468 gccccggctt acaatcatgt 20 <210> 469 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 469 gtctcggctg aggccccacgg 20 <210> 470 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 470 atggccatac ccatcgatgc 20 <210> 471 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 471 aagcagcccc agggattgcg 20 <210> 472 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 472 caccccggac gatccaccct 20 <210> 473 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 473 accctgaatg gtccacccca 20 <210> 474 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 474 gagatccatc ccagatggtt 20 <210> 475 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 475 gtccacccaa gagggtccac 20 <210> 476 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 476 ggtggagacc ccacctaggt 20 <210> 477 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 477 ctgccccaga cgcaccgtca 20 <210> 478 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 478 cacgcgccct gccccagacg 20 <210> 479 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 479 ccggccttac ttcttgtggg 20 <210> 480 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 480 gcactcactc taccacggag 20 <210> 481 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 481 gtagcccttc acatacctgg 20 <210> 482 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 482 gtggttcatt ccagactgga 20 <210> 483 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 483 gtcccttgtc aatacaagga 20 <210> 484 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 484 tcgcccttac tcatcagtgg 20 <210> 485 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 485 aggtccatac cccaccggcc 20 <210> 486 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 486 ggtccccacc agtcttgttc 20 <210> 487 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 487 tccgaccttt actccaggcc 20 <210> 488 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 488 cgggtgctcc ctaaacctgg 20 <210> 489 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 489 acagcacgcc aagaccgcta 20 <210> 490 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 490 cgtgccccac cctcaccttt 20 <210> 491 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 491 actggcagaa tcatcagtaa 20 <210> 492 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 492 agcgaactta attatatctc 20 <210> 493 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 493 caccccagac gatccaccct 20 <210> 494 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 494 ccacactcca ctccaaggca 20 <210> 495 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 495 ctcccatcct atacacacca 20 <210> 496 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 496 cgccattccc agagtccaca 20 <210> 497 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 497 gccttgccac acaaaacagt 20 <210> 498 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 498 agcacatcct ggccttgccc 20 <210> 499 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 499 ggttctgccc tcttctgacc 20 <210> 500 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 500 gactcaccca accctaccat 20 <210> 501 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 501 ccacacgcaa caaaggcacc 20 <210> 502 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 502 gatgacggtc ccatgctgat 20 <210> 503 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 503 ctctcacacc tctaagagcc 20 <210> 504 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 504 gcgaggccac ccatgtgaaa 20 <210> 505 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 505 agctgaacca cccacagaga 20 <210> 506 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 506 caccgtgtaa caacacccca 20 <210> 507 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 507 accgcaaccc cttctgcttg 20 <210> 508 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 508 ctgccgtttt caagaattaa 20 <210> 509 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 509 acccttagcc ctcatcagga 20 <210> 510 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 510 gactctagtt acaaacatga 20 <210> 511 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 511 acgatccatt ttcccctgca 20 <210> 512 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 512 agagggagtc ctatcattca 20 <210> 513 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 513 cctggtgcca cacctccctt 20 <210> 514 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 514 cctccatgca cccgtgccac 20 <210> 515 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 515 tcaggggact ccatcattac 20 <210> 516 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 516 cggacacaca acatacgcaa 20 <210> 517 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 517 gttttaagca caccatcccg 20 <210> 518 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 518 cttcatagca acccatgcct 20 <210> 519 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 519 caccctggac agtctaccct 20 <210> 520 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 520 gaaagccaca cacaactggc 20 <210> 521 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 521 ggcaggcccc ttccctctca 20 <210> 522 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 522 gtacatccca catctgcggg 20 <210> 523 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 523 ggcataaaca cacttacacc 20 <210> 524 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 524 cccccgacat acacagcatc 20 <210> 525 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 525 accagcccaa gcatacccca 20 <210> 526 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 526 ggagtactct ccacagaccc 20 <210> 527 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 527 ggaggtcccc tccgtggccg 20 <210> 528 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 528 gcccatggct tcatcaacgg 20 <210> 529 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 529 gaacacagaa tcctgtgaac 20 <210> 530 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 530 gggacccttc tccctacgct 20 <210> 531 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 531 ccctgcccca gacgcaccgt 20 <210> 532 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 532 ttgaccccac cccagaggca 20 <210> 533 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 533 acccagtcat gaactaggtc 20 <210> 534 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 534 gcccctgttc tattttgagc 20 <210> 535 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 535 tctactctgc ccaaggccct 20 <210> 536 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 536 gtgtcctcac acgctcctcc 20 <210> 537 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 537 ccttgcagaa ttcttgcagc 20 <210> 538 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 538 tagcaaagct gatctagccc 20 <210> 539 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 539 agacgcatcc atttcctcca 20 <210> 540 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 540 ggcactggct cctatcaatc 20 <210> 541 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 541 gggcttttcc caggcaggcc 20 <210> 542 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 542 taatcagctc ccaatccctc 20 <210> 543 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 543 ctgtgtccac acctgcggga 20 <210> 544 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 544 cttcatgcct ccagaatgca 20 <210> 545 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 545 tgaagatcc tccccgcagc 20 <210> 546 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 546 accagacccc agaatctcct 20 <210> 547 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 547 accagcagca tccttaataa 20 <210> 548 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 548 cagcccggcc ttacttcttg 20 <210> 549 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 549 cccaggcaaa ccgcccagca 20 <210> 550 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 550 gacctttact ccaggcctca 20 <210> 551 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 551 acgaaggtca ccatccacct 20 <210> 552 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 552 ttggacacca tcccgggcct 20 <210> 553 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 553 cagagtgcag aacagcagcc 20 <210> 554 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 554 gccctgttct ctgaagcaac 20 <210> 555 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 555 atcactgtcc caatcacccc 20 <210> 556 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 556 tccatggaaa tgcaccatct 20 <210> 557 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 557 gggccagtcc ccttctctac 20 <210> 558 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 558 caagagaaca tctgtgccgt 20 <210> 559 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 559 cagtagggca ccacagccac 20 <210> 560 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 560 gtgaggtgcc atccggggca 20 <210> 561 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 561 ggcggtacat ccacgggctc 20 <210> 562 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 562 ggtgccttcc tttgccgtaa 20 <210> 563 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 563 cttccacctt acccagacct 20 <210> 564 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 564 gtggtccccc tcgccacgca 20 <210> 565 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 565 agacccctca ccaaacatcc 20 <210> 566 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 566 cggcaggtcc ctgacaggca 20 <210> 567 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 567 ttcatagcaa cccatgccta 20 <210> 568 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 568 gtagggcacc acagccacta 20 <210> 569 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 569 gagacgggct tccttgcatc 20 <210> 570 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 570 gcatctgtat cccctcgccc 20 <210> 571 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 571 tcctgtgaac ttcctcccct 20 <210> 572 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 572 cactggctcc tatcaatcga 20 <210> 573 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 573 agatggtcca ccccacatga 20 <210> 574 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 574 ccagggctga cccttggact 20 <210> 575 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 575 ggacacacaa catacgcaac 20 <210> 576 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 576 ccatgggcct ccacctgctc 20 <210> 577 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 577 aaggtcacca tccacctggc 20 <210> 578 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 578 cagcacggcc tccccgagct 20 <210> 579 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 579 agtctgggcc ctccaggccg 20 <210> 580 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 580 acacaccaac accacagggc 20 <210> 581 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 581 cccctgttct attttgagcc 20 <210> 582 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 582 ccagacgatc caccctaaat 20 <210> 583 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 583 cccaccctca cctttgggtc 20 <210> 584 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 584 cctttactcc aggcctcagt 20 <210> 585 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 585 gagtactctc cacagacccc 20 <210> 586 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 586 tggtgccaca cctcccttca 20 <210> 587 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 587 actggaaacc atccacagat 20 <210> 588 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 588 ttctgccctc ttctgaccta 20 <210> 589 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 589 cacaggtgct actcacacaa 20 <210> 590 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 590 ttcatgcctc cagaatgcat 20 <210> 591 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 591 ccgttttcaa gaattaacca 20 <210> 592 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 592 gaggaagcca ccacctgtca 20 <210> 593 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 593 tgtgtcctga ccattttcaa 20 <210> 594 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 594 caaaggcacc cccttatctc 20 <210> 595 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 595 gagagaagcc tctctctgtt 20 <210> 596 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 596 acttggcccc aaacctaggc 20 <210> 597 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 597 aagccacaca caactggctt 20 <210> 598 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 598 actaggtcac ccacccagga 20 <210> 599 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 599 tacatccccac atctgcggga 20 <210> 600 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 600 aagctgatct agcccaggtc 20 <210> 601 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 601 ccttgccaca caaaacagtt 20 <210> 602 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 602 ccgtggccaa ctctcgggtc 20 <210> 603 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 603 tcccagagtc cacacccggc 20 <210> 604 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 604 tggctttttc catcctggga 20 <210> 605 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 605 gcatcctgcc ccagacgcac 20 <210> 606 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 606 gctacagctc ccatgctgca 20 <210> 607 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 607 gaaccaccca cagagaggcc 20 <210> 608 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 608 tgtgtccaca cctgcgggat 20 <210> 609 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 609 tggaaatgca ccatcttccg 20 <210> 610 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 610 ggcttcggcc tcactcacct 20 <210> 611 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 611 gggcaggcac tcactttgta 20 <210> 612 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 612 cccgggcctt tcctgctcca 20 <210> 613 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 613 gaagccgcac ctccactgcc 20 <210> 614 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 614 tttaagcaca ccatccccgga 20 <210> 615 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 615 cacactccac tccaaggcaa 20 <210> 616 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 616 gctgagggtc ccaaacccag 20 <210> 617 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 617 cggccttact tcttgtgggc 20 <210> 618 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 618 gacgcatcca tttcctccac 20 <210> 619 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 619 aggatcttcg caacttgctg 20 <210> 620 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 620 ccctcaccaa acatccccg 20 <210> 621 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 621 atttggccca ccacacacgg 20 <210> 622 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 622 agccctgatc cctcttgcaa 20 <210> 623 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 623 agagtgcaga acagcagccc 20 <210> 624 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 624 tcactgtccc aatcaccccc 20 <210> 625 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 625 aatcagctcc caatccctcc 20 <210> 626 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 626 tgacggtccc atgctgatca 20 <210> 627 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 627 gcgatctgtc ttcacgagtc 20 <210> 628 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 628 ctggcagaat catcagtaac 20 <210> 629 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 629 gcgaacttaa ttatatctcc 20 <210> 630 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 630 cccatggctt catcaacgga 20 <210> 631 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 631 gcagtggtta tactgaacct 20 <210> 632 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 632 ctaagagccc ttgtctgcca 20 <210> 633 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 633 acctgagaca cccccatggc 20 <210> 634 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 634 ggctgttaca tccgcagtga 20 <210> 635 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 635 tctgaagcaa ccccccagct 20 <210> 636 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 636 gaagcaagcc cctttgggca 20 <210> 637 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 637 acgggactcc atcattaccc 20 <210> 638 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 638 ggagtgagtc ccagtggtta 20 <210> 639 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 639 agggagtcct atcattcaga 20 <210> 640 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 640 gccgccagcc ttaccttgtc 20 <210> 641 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 641 aaacacactt acacccattc 20 <210> 642 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 642 ccagcagcat ccttaataat 20 <210> 643 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 643 cactgtccca atcaccccca 20 <210> 644 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 644 tccctcctgt cctatacaca 20 <210> 645 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 645 ccaggaagct tattatggcc 20 <210> 646 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 646 ggtagcccca acccaacagc 20 <210> 647 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 647 gacggcctga cacctgcccc 20 <210> 648 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 648 ccgctggctc ttttctgccc 20 <210> 649 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 649 tggttatact gaacctgttt 20 <210> 650 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 650 aaatgcacca tcttccgccc 20 <210> 651 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 651 tcatgcctcc agaatgcatc 20 <210> 652 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 652 gccctcttct gacctagaca 20 <210> 653 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 653 gacgatccac cctaaatggt 20 <210> 654 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 654 ccacagaccc ctccttctga 20 <210> 655 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 655 ggctttttcc atcctgggac 20 <210> 656 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 656 ccctgttcta ttttgagcct 20 <210> 657 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 657 ctgaagcaac cccccagctt 20 <210> 658 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 658 ccaccctcac ctttgggtca 20 <210> 659 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 659 ggcgcagcca cacactcgcc 20 <210> 660 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 660 ggtgccacac ctcccttcaa 20 <210> 661 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 661 gggagtccta tcattcagaa 20 <210> 662 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 662 aacacactta cacccattcc 20 <210> 663 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 663 tggcagagca tctcactgac 20 <210> 664 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 664 ctgttgttct cccctccgct 20 <210> 665 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 665 ctacagctcc catgctgcac 20 <210> 666 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 666 gtggtttgct ttcctgatct 20 <210> 667 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 667 ggcctgtgca ctctccaccc 20 <210> 668 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 668 tgcagcaccc ataagtgggc 20 <210> 669 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 669 gccgcacctc cactgccaca 20 <210> 670 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 670 gcctgggcag ccataaagcc 20 <210> 671 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 671 cgtggccaac tctcgggtca 20 <210> 672 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 672 acgcatccat ttcctccaca 20 <210> 673 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 673 cctcaccaaa catccccccgt 20 <210> 674 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 674 acactccact ccaaggcaac 20 <210> 675 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 675 ccggaggtcc gaaatcccaa 20 <210> 676 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 676 ccgccagcct taccttgtcc 20 <210> 677 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 677 gagagcctcc cagccacgca 20 <210> 678 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 678 catctgtatc ccctcgcccg 20 <210> 679 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 679 gatgagcttc tctccacgcc 20 <210> 680 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 680 gtgagacctc ttgattgccc 20 <210> 681 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 681 tctgctcgcc ccccaacccg 20 <210> 682 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 682 agacagttcc tcccttgcaa 20 <210> 683 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 683 cctgtgaact tcctcccctt 20 <210> 684 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 684 ccttgcatct ctcactgggc 20 <210> 685 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 685 actggctcct atcaatcgaa 20 <210> 686 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 686 aaccacccac agagaggcca 20 <210> 687 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 687 atcctgcccc agacgcaccg 20 <210> 688 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 688 ccgggccttt cctgctccaa 20 <210> 689 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 689 tggtccaccc cacatgatct 20 <210> 690 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 690 tcatagcaac ccatgcctat 20 <210> 691 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 691 gtcccatgct gatcaagttc 20 <210> 692 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 692 ggcagaatca tcagtaacaa 20 <210> 693 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 693 acaactggct tcttctagaa 20 <210> 694 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 694 acacaatacc actcagacac 20 <210> 695 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 695 acaggtgcta ctcacacaat 20 <210> 696 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 696 cttggcccca aacctaggcc 20 <210> 697 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 697 cctgagacac ccccatggcc 20 <210> 698 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 698 tgtgggtcac acaggacagg 20 <210> 699 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 699 cgaacttaat tatatctccc 20 <210> 700 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 700 gccactgcga cctcattccg 20 <210> 701 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 701 aggagattcc ttctagggta 20 <210> 702 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 702 cttctgcacc cattcctgct 20 <210> 703 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 703 cgcccataca tgcgctgcca 20 <210> 704 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 704 ggcaccacag ccactagtgt 20 <210> 705 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 705 aaggcacccc cttatctcgg 20 <210> 706 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 706 tgtcctgacc attttcaacc 20 <210> 707 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 707 tcaggacacc gcaagtgctc 20 <210> 708 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 708 cgggactcca tcattaccca 20 <210> 709 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 709 aacagtttcc acagctggga 20 <210> 710 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 710 cctgtctccc ccaaagtggc 20 <210> 711 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 711 ctgagggtcc caaacccagc 20 <210> 712 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 712 tgtcagatgt cccacagcct 20 <210> 713 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 713 ttggcccacc acacacggca 20 <210> 714 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 714 atgtttgtca cagaaagtcc 20 <210> 715 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 715 cgatctgtct tcacgagtca 20 <210> 716 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 716 gccctgatcc ctcttgcaaa 20 <210> 717 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 717 gagtgcagaa cagcagccct 20 <210> 718 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 718 aagcaagccc ctttgggcaa 20 <210> 719 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 719 ttcttcagca cccatgctga 20 <210> 720 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 720 cgtgtatgcc atctccacct 20 <210> 721 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 721 aacttaatta tatctcccgt 20 <210> 722 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 722 cgctggctct tttctgcccc 20 <210> 723 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 723 tgctcaagac tccagggcga 20 <210> 724 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 724 gaaggacaat accttcggca 20 <210> 725 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 725 ccttgactaa tcactgtgga 20 <210> 726 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 726 gtagaggatc cacccaggga 20 <210> 727 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 727 caggaagctt attatggcca 20 <210> 728 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 728 ccactccaag gcaacaccca 20 <210> 729 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 729 agggtagccc ttcacatacc 20 <210> 730 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 730 gcagacaaag aacccggcca 20 <210> 731 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 731 ccactgcgac ctcattccgc 20 <210> 732 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 732 gtcatgtgtc caccacacgc 20 <210> 733 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 733 tggtttgctt tcctgatctc 20 <210> 734 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 734 ttctgcaccc attcctgctc 20 <210> 735 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 735 ggtgctactc acacaatgtc 20 <210> 736 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 736 tgcaaagcac ttactgagac 20 <210> 737 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 737 gggcaccgct tctatctcac 20 <210> 738 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 738 gtcctcagca ctcactgaac 20 <210> 739 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 739 gctttttcca tcctgggaca 20 <210> 740 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 740 ccctgatccc tcttgcaaac 20 <210> 741 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 741 ctggctccta tcaatcgaat 20 <210> 742 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 742 caagtgctca gaacatgccg 20 <210> 743 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 743 agcaaccccc cagcttgtcc 20 <210> 744 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 744 tcctgctcca ataaaccaga 20 <210> 745 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 745 caccacagcc actagtgtcc 20 <210> 746 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 746 gggactccat cattacccac 20 <210> 747 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 747 ttggccccaa acctaggcca 20 <210> 748 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 748 ggcccaagcc tccttgctgc 20 <210> 749 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 749 ccccagacgc accgtcaccc 20 <210> 750 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 750 gacacggcac ttcccgggac 20 <210> 751 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 751 gcagccataa agcctgccta 20 <210> 752 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 752 gcttgtccca ctcagggcct 20 <210> 753 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 753 tgagacaccc ccatggccaa 20 <210> 754 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 754 catgcctcca gaatgcatcc 20 <210> 755 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 755 tcattgtgaa atcccatgcc 20 <210> 756 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 756 gcgcagccac acactcgcca 20 <210> 757 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 757 tccacggaac tccatgggtc 20 <210> 758 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 758 gtactaagag ctactggcca 20 <210> 759 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 759 aatgcaccat cttccgccca 20 <210> 760 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 760 gctgagccgc catcatgctc 20 <210> 761 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 761 ctgctcgccc cccaacccgc 20 <210> 762 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 762 acggcctgac acctgcccct 20 <210> 763 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 763 acacacttac acccattcca 20 <210> 764 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 764 ctcgggtcat tcttcagcgg 20 <210> 765 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 765 atgccaggcc cccttgtgac 20 <210> 766 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 766 agggagataa actaaactct 20 <210> 767 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 767 gcagcaccca taagtgggca 20 <210> 768 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 768 caactggctt cttctagaac 20 <210> 769 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 769 ggccacaccc ttcctcctga 20 <210> 770 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 770 tgatcaagtt ctaatgggaa 20 <210> 771 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 771 tggcatggat cccctcccta 20 <210> 772 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 772 cctatggtat ccacagaccc 20 <210> 773 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 773 gtcctgacca ttttcaacct 20 <210> 774 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 774 gtagccccaa cccaacagca 20 <210> 775 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 775 ggcaccccct tatctcgggc 20 <210> 776 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 776 gaagagaaac ccttcaggcc 20 <210> 777 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 777 gagggtccca aacccagcaa 20 <210> 778 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 778 ccacagtccc agccccccgga 20 <210> 779 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 779 atgagcttct ctccacgcca 20 <210> 780 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 780 ccagacacac atcacatatc 20 <210> 781 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 781 tccctcccgt cctatagaca 20 <210> 782 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 782 cgcacctcca ctgccacaga 20 <210> 783 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 783 gcgctggcac caacaagatc 20 <210> 784 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 784 ctgtgaactt cctccccttc 20 <210> 785 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 785 ggtggaaact tctgcaggac 20 <210> 786 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 786 atctgtatcc cctcgcccgg 20 <210> 787 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 787 tacagctccc atgctgcact 20 <210> 788 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 788 cgttgccctc ccagccagcc 20 <210> 789 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 789 tcaccaaaca tcccccgtga 20 <210> 790 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 790 attttgagcc tccctagaac 20 <210> 791 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 791 acgatccacc ctaaatggtc 20 <210> 792 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 792 cttgcatctc tcactgggct 20 <210> 793 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 793 tgttgttctc ccctccgctc 20 <210> 794 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 794 gaggtccgaa atcccaagcc 20 <210> 795 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 795 ggtccacccc acatgatcta 20 <210> 796 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 796 ggagtcctat cattcagaac 20 <210> 797 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 797 tctgccccac atagaaacca 20 <210> 798 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 798 ctatcattca gaacagggac 20 <210> 799 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 799 gcaaagcact tactgagaca 20 <210> 800 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 800 gcacggcttc tatctcacac 20 <210> 801 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 801 gactccatca ttaccccacca 20 <210> 802 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 802 ggcatggatc ccctccctat 20 <210> 803 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 803 cccgtgaaca cccagccgtt 20 <210> 804 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 804 cctgctccaa taaaccagac 20 <210> 805 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 805 aactggcttc ttctagaaca 20 <210> 806 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 806 ggctgcccca gaacctccga 20 <210> 807 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 807 ggctgggaac tcacaattct 20 <210> 808 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 808 cattgtgaaa tcccatgcca 20 <210> 809 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 809 acagaattaa ttagctaatc 20 <210> 810 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 810 gcttctctcc acgccaggca 20 <210> 811 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 811 tagtgtcccc cagccaccct 20 <210> 812 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 812 ctgtcagaca ccccagggct 20 <210> 813 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 813 tcgggtcatt cttcagcgga 20 <210> 814 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 814 agcaagtgcc ctccccccgac 20 <210> 815 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 815 gagggacccc actgtggaca 20 <210> 816 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 816 aggaagctta ttatggccac 20 <210> 817 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 817 agaggatcca cccagggact 20 <210> 818 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 818 atccctcttg caaacacacc 20 <210> 819 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 819 ttgctttcct gatctcaaca 20 <210> 820 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 820 aggtctagga ctattatacc 20 <210> 821 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 821 ttgacacaca acacacatta 20 <210> 822 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 822 gggtagccct tcacatacct 20 <210> 823 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 823 gttgttctcc cctccgctcc 20 <210> 824 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 824 cccaacccgc ttcctaaccc 20 <210> 825 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 825 cggatttgct agctgagccc 20 <210> 826 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 826 ctgactgtcc ccctctgttt 20 <210> 827 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 827 acgcaggtgc agcccagcca 20 <210> 828 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 828 taggccagga caacaactca 20 <210> 829 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 829 tttgatgtca ctgcctggcc 20 <210> 830 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 830 ccaacagcaa cacactggtt 20 <210> 831 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 831 aggtccgaaa tcccaagcct 20 <210> 832 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 832 cagcagcacc cacttatcac 20 <210> 833 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 833 cctccagaat gcatccattt 20 <210> 834 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 834 ccaagcctcc ttgctgcggc 20 <210> 835 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 835 tcatgtgtcc accacacgcc 20 <210> 836 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 836 cgatccaccc taaatggtcc 20 <210> 837 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 837 cttcagcatt cactgagcct 20 <210> 838 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 838 tctgtatccc ctcgcccggc 20 <210> 839 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 839 gggagataaa ctaaactctt 20 <210> 840 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 840 ccccaggcta acagctgaa 20 <210> 841 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 841 ccgtcaggac ccaagccctc 20 <210> 842 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 842 tccaaggcaa cacccagcca 20 <210> 843 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 843 acttaattat atctcccgtg 20 <210> 844 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 844 tagggcaccc tctcttacat 20 <210> 845 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 845 cactgcgacc tcattccgcc 20 <210> 846 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 846 cggcctgaca cctgcccctc 20 <210> 847 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 847 tgctcagaaa atgaccaact 20 <210> 848 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 848 gtgctactca cacaatgtca 20 <210> 849 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 849 tgtgaacttc ctccccttcc 20 <210> 850 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 850 caggccttct ctccagggaa 20 <210> 851 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 851 tgggaacctc cttagtggcc 20 <210> 852 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 852 agcagcagtc ccagaagccc 20 <210> 853 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 853 gctatgggcc actgcagcct 20 <210> 854 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 854 gtcctgcccc agacgcaccg 20 <210> 855 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 855 acacttacac ccattccatt 20 <210> 856 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 856 agcttgtccc taagttggcc 20 <210> 857 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 857 gctccggaca cccaccagga 20 <210> 858 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 858 ttggagtccc cacccctgca 20 <210> 859 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 859 cgcagccaca cactcgccac 20 <210> 860 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 860 tactggccaa cctatgtgga 20 <210> 861 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 861 ccacggaact ccatgggtcc 20 <210> 862 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 862 tgacaaagat ttcccctagac 20 <210> 863 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 863 cacaccagcc cttccgtcca 20 <210> 864 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 864 cgtggcccac catccgatgc 20 <210> 865 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 865 gtgtatgcca tctccacctc 20 <210> 866 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 866 tctgcaccca ttcctgctcc 20 <210> 867 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 867 ggcactgtgt caacttgata 20 <210> 868 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 868 ctgggcagaa cctgctatcc 20 <210> 869 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 869 gacccctgca cactcactca 20 <210> 870 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 870 caccccacat gatctacact 20 <210> 871 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 871 cccctcctgt cctatagaca 20 <210> 872 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 872 gcagcaccca cttatcactt 20 <210> 873 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 873 gctactcaca caatgtcact 20 <210> 874 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 874 gcccgtctca cctctgccag 20 <210> 875 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 875 gagaagctgc taactccaga 20 <210> 876 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 876 tcgcccggcc ctgcttgcct 20 <210> 877 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 877 tagcccttca catacctggg 20 <210> 878 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 878 gggccaggtc cactcccatc 20 <210> 879 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 879 cgcgcgcccc tacctctggc 20 <210> 880 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 880 gtctaggact attataccca 20 <210> 881 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 881 gctgggaact cacaattctc 20 <210> 882 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 882 gcacggcaac cctccagggc 20 <210> 883 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 883 aaaggagcct accttgcctt 20 <210> 884 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 884 ttgcggtaca tctgtgtaaa 20 <210> 885 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 885 cctgccccag acgcaccgtc 20 <210> 886 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 886 cccctgcaca ctcactcata 20 <210> 887 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 887 gggctgtcgg tcacttgtca 20 <210> 888 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 888 tcagaaaatg accaactcac 20 <210> 889 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 889 gtgaacttcc tccccttccg 20 <210> 890 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 890 tgccccagaa cctccgaggt 20 <210> 891 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 891 cctcttgcaa acacaccctt 20 <210> 892 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 892 cgtacttgca ctcctcctca 20 <210> 893 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 893 cggacaccca ccaggagagc 20 <210> 894 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 894 actggcttct tctagaacac 20 <210> 895 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 895 ccatcattac ccaccatgct 20 <210> 896 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 896 ccaggacccc atcccagtgt 20 <210> 897 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 897 acagtgacaa ccccgaccct 20 <210> 898 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 898 gatccaccct aaatggtcca 20 <210> 899 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 899 tacacccatt ccatttcagc 20 <210> 900 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 900 caacagcaac acactggttc 20 <210> 901 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 901 gggaacctcc ttagtggccc 20 <210> 902 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 902 actgcgacct cattccgcca 20 <210> 903 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 903 aacctgctat ccctatgggc 20 <210> 904 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 904 agacgaggcc tttaaagcgg 20 <210> 905 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 905 tccgctagct cctcagagtc 20 <210> 906 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 906 tgacacacaa cacacattac 20 <210> 907 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 907 catgggtcca cacctgatgc 20 <210> 908 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 908 gtggcccacc atccgatgcc 20 <210> 909 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 909 ggctggtgac cccaacatct 20 <210> 910 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 910 cctgggttcc ctacttactg 20 <210> 911 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 911 cacggcttct atctcacacc 20 <210> 912 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 912 gtatgccatc tccacctcct 20 <210> 913 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 913 agcctgttca tctcagcagc 20 <210> 914 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 914 gccttgaccc tcactcccat 20 <210> 915 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 915 ccaacccgct tcctaaccct 20 <210> 916 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 916 caaggcaaca cccagccagc 20 <210> 917 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 917 gcagggttca ccccgatggc 20 <210> 918 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 918 aattagctaa tcatcaggtt 20 <210> 919 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 919 accatcttcc gcccaatgcc 20 <210> 920 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 920 ggagataaac taaactcttc 20 <210> 921 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 921 gccaggacaa caactcagga 20 <210> 922 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 922 gtgaaatccc atgccagctt 20 <210> 923 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 923 gcttgtccct aagttggcca 20 <210> 924 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 924 agtctgtgtc ctccaagggc 20 <210> 925 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 925 gcaagtgccc tccccccgaca 20 <210> 926 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 926 cccacatgat ctacactgga 20 <210> 927 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 927 actggccaac ctatgtggaa 20 <210> 928 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 928 gccgaggtcc ctccagtggc 20 <210> 929 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 929 ctgctccaat aaaccagacc 20 <210> 930 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 930 ttgtggtcca cttctcagct 20 <210> 931 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 931 cacggaggcc acacttcccc 20 <210> 932 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 932 agaggctcga ccctatggct 20 <210> 933 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 933 gctgaaatct tctacaggaa 20 <210> 934 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 934 atgtgtccac cacacgcccc 20 <210> 935 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 935 atacctgtct ccccattcct 20 <210> 936 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 936 ccaggcttca ccgagctcct 20 <210> 937 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 937 gctcttttcc caaaacccat 20 <210> 938 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 938 agctctgtgc aaacaaggtc 20 <210> 939 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 939 gaacacccag ccgttagcct 20 <210> 940 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 940 ccgatgttct ccctccaaac 20 <210> 941 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 941 ccagaatgca tccatttaat 20 <210> 942 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 942 gaagtggtca tccctgcacc 20 <210> 943 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 943 gacaaagatt tccctagact 20 <210> 944 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 944 cggtgaccac caccctcccc 20 <210> 945 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 945 ttgttctccc ctccgctccg 20 <210> 946 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 946 ggcaccctct cttacatcca 20 <210> 947 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 947 tgactgtccc cctctgtttc 20 <210> 948 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 948 agcccaagca cacttcccac 20 <210> 949 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 949 acacccattc catttcagct 20 <210> 950 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 950 ctgggttccc tacttactga 20 <210> 951 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 951 gggcagtcgc cactctgcct 20 <210> 952 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 952 atcattaccc accatgctga 20 <210> 953 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 953 gaggctcgac cctatggcta 20 <210> 954 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 954 ctcggtgatt ttcatctgca 20 <210> 955 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 955 gagttctgac caactgacca 20 <210> 956 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 956 caccctctct tacatccagt 20 <210> 957 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 957 gagcacaccc ctctgccggc 20 <210> 958 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 958 tacctgtctc cccattcctc 20 <210> 959 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 959 tcgagggcac ccactccacc 20 <210> 960 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 960 acggcttcta tctcacaccc 20 <210> 961 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 961 gctggtgacc ccaacatctc 20 <210> 962 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 962 tgcgacctca ttccgccaac 20 <210> 963 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 963 atcgctccag tccttgcttc 20 <210> 964 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 964 cctgcttgcc tctcgggccc 20 <210> 965 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 965 tcacttgtca ccatggccat 20 <210> 966 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 966 atgggtccac acctgatgct 20 <210> 967 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 967 cccgtctcac ctctgccagt 20 <210> 968 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 968 cctccctttt tccttccgga 20 <210> 969 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 969 tctaggacta ttatacccag 20 <210> 970 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 970 gcacccactt atcacttctc 20 <210> 971 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 971 cagccgttag cctctcggcc 20 <210> 972 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 972 agctgctaac tccagaagga 20 <210> 973 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 973 gatggtgaca accacaccac 20 <210> 974 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 974 gtacttgcac tcctcctcac 20 <210> 975 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 975 ccgtacccta cacgctggaa 20 <210> 976 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 976 ccgaggtccc tccagtggca 20 <210> 977 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 977 gctcaaacca ccgccaggac 20 <210> 978 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 978 gacgaggcct ttaaagcggt 20 <210> 979 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 979 agtggtcatc cctgcaccca 20 <210> 980 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 980 ctccaaacaa ttatgcgatt 20 <210> 981 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 981 tggagacctc tcctctgctt 20 <210> 982 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 982 gagctgcctt gaacaaggct 20 <210> 983 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 983 ctggatggtc caccctgaac 20 <210> 984 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 984 cttttcccaa aacccatggt 20 <210> 985 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 985 ctaaatggtc caccccggac 20 <210> 986 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 986 acggaggcca cacttccccc 20 <210> 987 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 987 agaaaatgac caactcactg 20 <210> 988 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 988 ggccaggtcc actcccatcc 20 <210> 989 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 989 gaaatcttct acaggaagcc 20 <210> 990 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 990 ccggctgttc ccctccacct 20 <210> 991 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 991 tgtggtccac ttctcagctt 20 <210> 992 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 992 ctggatttgt ccatactccc 20 <210> 993 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 993 taggttaaaa aactctcctc 20 <210> 994 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 994 acaaagatt ccctagactt 20 <210> 995 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 995 gtcggctgca caaaccctgc 20 <210> 996 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 996 gcatgccgtc ctccacatcc 20 <210> 997 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 997 ctgggtggca ccttcagaaa 20 <210> 998 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 998 tcttccgccc aatgccccct 20 <210> 999 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 999 gctccaataa accagacctt 20 <210> 1000 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1000 aactgagtgc ccaaaactac 20 <210> 1001 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1001 tgggaactca caattctcaa 20 <210> 1002 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1002 gagataaact aaactcttca 20 <210> 1003 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1003 caggacccca tcccagtgtc 20 <210> 1004 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1004 cgcttcctaa ccctgcaggc 20 <210> 1005 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1005 cagaatgcat ccatttaata 20 <210> 1006 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1006 gagctgagtc tttccggcct 20 <210> 1007 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1007 aagcacactt cccaccacaa 20 <210> 1008 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1008 gacacccacc aggagagcca 20 <210> 1009 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1009 ggcccaccat ccgatgccca 20 <210> 1010 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1010 atcccatgcc agcttctcct 20 <210> 1011 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1011 gtccgtagca gaacttggct 20 <210> 1012 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1012 agagactcgc tcatcagcga 20 <210> 1013 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1013 aaggagccta ccttgccttt 20 <210> 1014 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1014 cccagctcca tcctgattca 20 <210> 1015 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1015 ccccctctgt ttcaaagctc 20 <210> 1016 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1016 aggcaacacc cagccagctc 20 <210> 1017 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1017 acctgctatc cctatgggcc 20 <210> 1018 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1018 ttgaccctca ctcccatgtc 20 <210> 1019 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1019 ggtgacttcc caactggctc 20 <210> 1020 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1020 gacacacccc ccttgcacac 20 <210> 1021 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1021 tgtgtccacc acacgccccc 20 <210> 1022 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1022 atgctgctcc atgggagcac 20 <210> 1023 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1023 acggcaaccc tccagggccg 20 <210> 1024 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1024 ggagaccaca gaactccaga 20 <210> 1025 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1025 ctactgaccc cagcttgcca 20 <210> 1026 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1026 gcctgacagc ccctgtgcca 20 <210> 1027 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1027 gtggcacctt cagaaaggcc 20 <210> 1028 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1028 ctttccggcc ttcctgacca 20 <210> 1029 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1029 gagctcgcaa aaggctgccc 20 <210> 1030 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1030 aactgccctt ttagagagca 20 <210> 1031 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1031 ggagacctct cctctgcttc 20 <210> 1032 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1032 tggtgttgct caactccaga 20 <210> 1033 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1033 ggccacactt ccccccggaa 20 <210> 1034 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1034 acccgagaca ccatctggta 20 <210> 1035 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1035 cgcacaggca caaaatgccc 20 <210> 1036 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1036 catgccgtcc tccacatcca 20 <210> 1037 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1037 gggcatcaac cagaatgcgg 20 <210> 1038 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1038 ggatggtcca ccctgaacag 20 <210> 1039 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1039 gaccttgact caatcatgca 20 <210> 1040 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1040 ggcatggttc tctctaggcg 20 <210> 1041 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1041 cgagcatccc cctacgcctc 20 <210> 1042 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1042 ccaactgacc atgccaggac 20 <210> 1043 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1043 cacacttccc accacaaggc 20 <210> 1044 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1044 cggctgttcc cctccacctg 20 <210> 1045 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1045 accacagaac tccagaagca 20 <210> 1046 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1046 cccccaaccc tccatcggtc 20 <210> 1047 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1047 actgagtgcc caaaactaca 20 <210> 1048 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1048 gaatgcatcc atttaataga 20 <210> 1049 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1049 gccccagacg caccgtcaca 20 <210> 1050 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1050 agggagacac accctcccca 20 <210> 1051 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1051 ccctttttcc ttccggagtc 20 <210> 1052 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1052 accacacgcc cccccacgca 20 <210> 1053 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1053 cggcttctat ctcacacccg 20 <210> 1054 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1054 gactcgctca tcagcgagaa 20 <210> 1055 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1055 aggaccccat cccagtgtcc 20 <210> 1056 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1056 ttgcctgtcc tcaccagggt 20 <210> 1057 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1057 ctggtgaccc caacatctcc 20 <210> 1058 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1058 tggatttgtc catactccca 20 <210> 1059 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1059 cacccactta tcacttctca 20 <210> 1060 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1060 gaactcacaa ttctcaaact 20 <210> 1061 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1061 cctgtctgtc ttcagcattc 20 <210> 1062 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1062 ccccatgccc tactcggtct 20 <210> 1063 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1063 catgtgtgca tacaccggca 20 <210> 1064 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1064 cacccattcc atttcagctg 20 <210> 1065 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1065 tgaccctcac tcccatgtca 20 <210> 1066 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1066 attccgccaa ctcctggccc 20 <210> 1067 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1067 cctctcttac atccagtcga 20 <210> 1068 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1068 cgtgagtcct cagagcactt 20 <210> 1069 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1069 tacttgcact cctcctcaca 20 <210> 1070 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1070 ccccattcct cctttgtata 20 <210> 1071 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1071 gataaactaa actcttcacc 20 <210> 1072 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1072 cttccgccca atgcccccta 20 <210> 1073 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1073 cctgcaccca cctcgcaggc 20 <210> 1074 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1074 cggctgcaca aaccctgcca 20 <210> 1075 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1075 tcggtgattt tcatctgcag 20 <210> 1076 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1076 ccgtagtgac cctaaaagtc 20 <210> 1077 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1077 gtgacttccc aactggctct 20 <210> 1078 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1078 gcctcgcttt accctcccaa 20 <210> 1079 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1079 taggactatt atacccagcc 20 <210> 1080 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1080 ggtgacaacc acaccacaca 20 <210> 1081 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1081 cctgctatcc ctatgggccc 20 <210> 1082 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1082 atgctgagca ccaccggacc 20 <210> 1083 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1083 acgaggcctt taaagcggtc 20 <210> 1084 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1084 tccagggaac ccctttcctt 20 <210> 1085 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1085 gcctggcggc caacagcacc 20 <210> 1086 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1086 aggtccactc ccatccttca 20 <210> 1087 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1087 ccctctgttt caaagctcca 20 <210> 1088 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1088 accatggcca tacccatcga 20 <210> 1089 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1089 gaaggttccc caagagagga 20 <210> 1090 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1090 gccgttagcc tctcggccca 20 <210> 1091 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1091 gcttcctaac cctgcaggcc 20 <210> 1092 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1092 gctacgcttc cttggaggcc 20 <210> 1093 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1093 cgctcccgat acctgcccta 20 <210> 1094 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1094 gtccttgctt cccctgctca 20 <210> 1095 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1095 aacagccgga tcctcaggcc 20 <210> 1096 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1096 agaggaagct cctatcccca 20 <210> 1097 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1097 aggttaaaaa actctcctca 20 <210> 1098 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1098 ccggacgatc caccctggac 20 <210> 1099 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1099 ggtgctcaca ctgacggccg 20 <210> 1100 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1100 ccggtgagac tcatgggcat 20 <210> 1101 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1101 gagggcaccc actccaccca 20 <210> 1102 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1102 cggacgatcc accctggaca 20 <210> 1103 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1103 cttcagcatt cactaaagtc 20 <210> 1104 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1104 ccccagacgc accgtcacac 20 <210> 1105 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1105 tagcccagca caccccatct 20 <210> 1106 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1106 gccacacttc cccccggaac 20 <210> 1107 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1107 tggccatacc catcgatgca 20 <210> 1108 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1108 tgccacagcc tcagtggcac 20 <210> 1109 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1109 cctaagctgc ttctgaggac 20 <210> 1110 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1110 tcagacagtc ccttgtgtac 20 <210> 1111 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1111 gttgagctgc caaccggtcc 20 <210> 1112 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1112 ccgtccagcc ccactctacc 20 <210> 1113 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1113 caggctggca tctctaaggc 20 <210> 1114 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1114 ggacagggac caactcccgg 20 <210> 1115 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1115 tcatctcctt ctccagcgac 20 <210> 1116 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1116 cctgcagccc atgacactac 20 <210> 1117 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1117 gcattgggaa ttacaacctg 20 <210> 1118 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1118 gtctgtggac ctcaaccccc 20 <210> 1119 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1119 agccagggcc catccctgac 20 <210> 1120 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1120 cgaggccttt aaagcggtca 20 <210> 1121 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1121 tactcggtct ttctcctccc 20 <210> 1122 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1122 gagggcagct ctagtaggtt 20 <210> 1123 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1123 ggtccaccct gaacagtcca 20 <210> 1124 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1124 actggttccc agacacccct 20 <210> 1125 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1125 tgtgcataca ccggcaggcc 20 <210> 1126 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1126 ggtccactcc catccttcac 20 <210> 1127 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1127 gtggagaccc cacctaggtg 20 <210> 1128 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1128 cgtagtgacc ctaaaagtcc 20 <210> 1129 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1129 acacttccca ccacaaggcg 20 <210> 1130 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1130 atgccgtcct ccacatccac 20 <210> 1131 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1131 cgctgcttcc accaagatta 20 <210> 1132 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1132 cctccatcgg tcataggcct 20 <210> 1133 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1133 acgcagagct ctgtgtgccc 20 <210> 1134 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1134 ccacttatca cttctcagtt 20 <210> 1135 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1135 gtggaagtca ttctgtggaa 20 <210> 1136 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1136 tcacacggcc atctccttct 20 <210> 1137 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1137 tgagtgccca aaactacagc 20 <210> 1138 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1138 ggctgctcca cagtgggtat 20 <210> 1139 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1139 gatcactgcc ctcccccttc 20 <210> 1140 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1140 aggactatta tacccagcca 20 <210> 1141 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1141 agggcaccca ctccacccac 20 <210> 1142 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1142 cctcactccc atgtcaggac 20 <210> 1143 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1143 gtgacaacca caccacacac 20 <210> 1144 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1144 ctgtttcaaa gctccagcta 20 <210> 1145 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1145 actaaactct tcacctgggc 20 <210> 1146 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1146 cccgatacct gccctagcgc 20 <210> 1147 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1147 actgcccttt tagagagcac 20 <210> 1148 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1148 caccagggtc ctcacccccc 20 <210> 1149 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1149 gcccacagcc ctttcacggc 20 <210> 1150 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1150 tcttacatcc agtcgaggca 20 <210> 1151 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1151 tactgacccc agcttgccat 20 <210> 1152 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1152 gctcttggca tccacggtca 20 <210> 1153 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1153 cccgagacac catctggtaa 20 <210> 1154 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1154 aacagcacct tgactagcac 20 <210> 1155 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1155 cccaatgccc cctagatgca 20 <210> 1156 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1156 ggccgacaac cagatggaaa 20 <210> 1157 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1157 gcacaggcac aaaatgcccc 20 <210> 1158 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1158 ggctgcacaa accctgccaa 20 <210> 1159 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1159 cctaagggct ttctcaccca 20 <210> 1160 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1160 gtgattttca tctgcagggt 20 <210> 1161 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1161 ccagggaacc cctttccttg 20 <210> 1162 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1162 tgcatccatt taatagaagt 20 <210> 1163 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1163 gcttctatct cacacccgtc 20 <210> 1164 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1164 cccattcctc ctttgtataa 20 <210> 1165 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1165 aagtgattaa aacattcgat 20 <210> 1166 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1166 cttgccttca cttgcaggca 20 <210> 1167 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1167 ccttggcctc cagatacggc 20 <210> 1168 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1168 gagacctctc ctctgcttca 20 <210> 1169 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1169 cttgactcaa tcatgcaggt 20 <210> 1170 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1170 actcacaatt ctcaaactgc 20 <210> 1171 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1171 cctcgcttta ccctcccaac 20 <210> 1172 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1172 gcatggttct ctctaggcgg 20 <210> 1173 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1173 tctttatcct tccactgggc 20 <210> 1174 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1174 ccacagaact ccagaagcaa 20 <210> 1175 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1175 gtgacaacca cactcgagga 20 <210> 1176 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1176 cacctggtgt ccaaactcac 20 <210> 1177 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1177 ggttaaaaaa ctctcctcac 20 <210> 1178 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1178 gtgttgctca actccagaga 20 <210> 1179 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1179 cacttggaca cagtgagcaa 20 <210> 1180 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1180 tcacaattct caaactgctc 20 <210> 1181 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1181 tgcacaagaa cttcctgcca 20 <210> 1182 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1182 agtggcaccc tccctctact 20 <210> 1183 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1183 agtgcccaaa actacagcgg 20 <210> 1184 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1184 gctgcttcca ccaagatac 20 <210> 1185 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1185 tccctttacc tccccgtgga 20 <210> 1186 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1186 ggctttctca cccagagccg 20 <210> 1187 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1187 ggcctgaacc agctctatct 20 <210> 1188 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1188 gcatccattt aatagaagtt 20 <210> 1189 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1189 ggcaggtgcc catccaccca 20 <210> 1190 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1190 tctgtggacc tcaaccccct 20 <210> 1191 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1191 gcgcacggcc ccatctgaac 20 <210> 1192 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1192 cttggcctcc agatacggcc 20 <210> 1193 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1193 gttaaaaaac tctcctcact 20 <210> 1194 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1194 gaacagtcca tcccagatga 20 <210> 1195 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1195 cccacagccc tttcacggcc 20 <210> 1196 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1196 ccacacctgc ctctcggctc 20 <210> 1197 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1197 ggccttagtc ctattgaatt 20 <210> 1198 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1198 aggctgcaat tcaacactgc 20 <210> 1199 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1199 gctgagtaag gaaaatcccc 20 <210> 1200 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1200 ggtcccctgt ttactgatcc 20 <210> 1201 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1201 gcccgttctt cccttaacca 20 <210> 1202 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1202 ttcgatgttt cccaaagctc 20 <210> 1203 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1203 atggccggca ccctcccccg 20 <210> 1204 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1204 gagacattca cccagggctg 20 <210> 1205 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1205 gacaagcggc ccccaagcca 20 <210> 1206 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1206 ggacgatcca ccctggacag 20 <210> 1207 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1207 acctggtgtc caaactcaca 20 <210> 1208 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1208 caaagcttct cctctctgga 20 <210> 1209 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1209 tgtcaggaca gtcttagcca 20 <210> 1210 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1210 gggaattaca acctgaagcc 20 <210> 1211 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1211 gcggagagcc cacacgccat 20 <210> 1212 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1212 gctgggtgtt tacccaagac 20 <210> 1213 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1213 actcggtctt tctcctccca 20 <210> 1214 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1214 gccataccca tcgatgcaat 20 <210> 1215 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1215 ccctcaaccc ccatgcacgc 20 <210> 1216 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1216 gtgacgagca cccagtggga 20 <210> 1217 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1217 cacttcccac cacaaggcgc 20 <210> 1218 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1218 cagaactcga ttcacaggta 20 <210> 1219 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1219 cgcctgagca ctcttacgca 20 <210> 1220 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1220 tctgaggcca tcttgaggga 20 <210> 1221 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1221 ggagagggcc acccttcagc 20 <210> 1222 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1222 tctaccccag acaatccacc 20 <210> 1223 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1223 tgttgctcaa ctccagagaa 20 <210> 1224 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1224 gcaaacaccc ctgaaagaca 20 <210> 1225 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1225 taggcggaca gcaaaagcct 20 <210> 1226 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1226 tgggtcagcc tccaagaggc 20 <210> 1227 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1227 ctaaactctt cacctgggca 20 <210> 1228 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1228 aggctggcat ctctaaggca 20 <210> 1229 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1229 atccgcagca tccaaaccca 20 <210> 1230 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1230 cctaaaagtc ctatctgccc 20 <210> 1231 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1231 ccatggcgaa caacttgtcc 20 <210> 1232 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1232 gtcgaggcaa tttctcagga 20 <210> 1233 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1233 ccagggccca tccctgaccg 20 <210> 1234 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1234 gttgggagaa aaacaaccac 20 <210> 1235 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1235 ttatgacacc cattctggac 20 <210> 1236 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1236 cacttatcac ttctcagttc 20 <210> 1237 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1237 accttgacta gcacaagccc 20 <210> 1238 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1238 ccagcacacc ccatctcagt 20 <210> 1239 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1239 gctgagatag aaacaatggc 20 <210> 1240 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1240 tttcaaagct ccagctacac 20 <210> 1241 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1241 cccacggcca cacctgtgtc 20 <210> 1242 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1242 gtccagcccc actctaccct 20 <210> 1243 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1243 atccacggtc actcccgcct 20 <210> 1244 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1244 caatgccccc tagatgcagt 20 <210> 1245 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1245 atccaagtaa acatcgccag 20 <210> 1246 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1246 ccagacgcac cgtcacacat 20 <210> 1247 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1247 gagggtccac catcaggtcc 20 <210> 1248 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1248 tcctcacccc ccaattccta 20 <210> 1249 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1249 ccttcccccc acgccagcat 20 <210> 1250 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1250 tctccagcga ctctgaacct 20 <210> 1251 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1251 ctttatcctt ccactgggcc 20 <210> 1252 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1252 ctcgctttac cctcccaaca 20 <210> 1253 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1253 ccatctcctt ctgcctgtta 20 <210> 1254 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1254 tgccgtcctc cacatccaca 20 <210> 1255 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1255 cttctatctc acacccgtca 20 <210> 1256 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1256 ggcagaagcc cccaactcac 20 <210> 1257 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1257 aaagcttctc ctctctggac 20 <210> 1258 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1258 cgtggctcac ctaccgtggc 20 <210> 1259 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1259 gccgtcctcc acatccacac 20 <210> 1260 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1260 ggacagtcca cctagatggt 20 <210> 1261 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1261 cccacgccag catccaggaa 20 <210> 1262 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1262 agcaaaagcc tctgctgtcc 20 <210> 1263 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1263 ctggcaagac cacgaagcca 20 <210> 1264 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1264 gttccgtgaa tttccctgaa 20 <210> 1265 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1265 ggagagccca cacgccatac 20 <210> 1266 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1266 gcaggtgccc atccacccac 20 <210> 1267 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1267 ccacagccct ttcacggcct 20 <210> 1268 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1268 ctaaaagtcc tatctgccca 20 <210> 1269 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1269 tgagatagaa acaatggcct 20 <210> 1270 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1270 aaaaaactct cctcactagc 20 <210> 1271 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1271 aaactcttca cctgggcatt 20 <210> 1272 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1272 tccagcgact ctgaacctct 20 <210> 1273 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1273 ggctgcaatt caacactgcc 20 <210> 1274 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1274 cacacctgcc tctcggctct 20 <210> 1275 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1275 cagggcccat ccctgaccga 20 <210> 1276 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1276 ccagctctat cttcccagac 20 <210> 1277 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1277 gcctgagcac tcttacgcat 20 <210> 1278 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1278 aacagtccat cccagatgac 20 <210> 1279 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1279 gcttccacca agattaccct 20 <210> 1280 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1280 tcatggtgcc cacccccaca 20 <210> 1281 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1281 accacagcccc acccctgcgg 20 <210> 1282 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1282 gaggccttgc ccaacagggc 20 <210> 1283 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1283 cccactctac cctctggcat 20 <210> 1284 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1284 aggccactcc acttcttgga 20 <210> 1285 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1285 gtggacctca accccctact 20 <210> 1286 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1286 gctttaccct cccaacaggt 20 <210> 1287 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1287 aactgactcc aggatcccta 20 <210> 1288 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1288 ttcaaagctc cagctacacc 20 <210> 1289 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1289 ttaatagaag tttccagcgc 20 <210> 1290 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1290 gcagggaacc ccaccacatc 20 <210> 1291 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1291 ggccaccagc tcatttcact 20 <210> 1292 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1292 agcacacccc atctcagtga 20 <210> 1293 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1293 cgttcttccc ttaaccacct 20 <210> 1294 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1294 tccgcagcat ccaaacccac 20 <210> 1295 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1295 gccttagtcc tattgaatta 20 <210> 1296 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1296 tcgatgtttc ccaaagctca 20 <210> 1297 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1297 ccccaagcca cctggaacca 20 <210> 1298 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1298 ggccatttct caggctggcc 20 <210> 1299 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1299 cccgcctgaa tccccccacgc 20 <210> 1300 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1300 gacaatccac cccagagggt 20 <210> 1301 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1301 ggtctgagca cacgctccta 20 <210> 1302 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1302 ctcggtcttt ctcctcccac 20 <210> 1303 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1303 acttcccacc acaaggcgca 20 <210> 1304 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1304 tccaagtaaa catcgccagt 20 <210> 1305 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1305 aggacagtct tagccaccaa 20 <210> 1306 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1306 gatggacgat atctcctgga 20 <210> 1307 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1307 tatgacaccc attctggaca 20 <210> 1308 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1308 ttggcctcca gatacggcca 20 <210> 1309 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1309 gagagggcca cccttcagcc 20 <210> 1310 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1310 accacagcca cctcaaagat 20 <210> 1311 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1311 ttctatctca cacccgtcac 20 <210> 1312 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1312 ctcacccccc aattcctacc 20 <210> 1313 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1313 aggtctcttc cctcagggac 20 <210> 1314 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1314 tgtgcataac acaaatattg 20 <210> 1315 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1315 agtgagctcc caactctgtc 20 <210> 1316 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1316 ggtgtccaaa ctcacaggct 20 <210> 1317 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1317 tcacaggtaa aagacacgac 20 <210> 1318 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1318 gagcaatgcc cacaaaggtg 20 <210> 1319 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1319 gtcttctgct tccttcagaa 20 <210> 1320 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1320 taaattggca ttaatgtctt 20 <210> 1321 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1321 cgcacggccc catctgaact 20 <210> 1322 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1322 gggctcagcc ctttcagacc 20 <210> 1323 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1323 ggcaccctcc ctctactggc 20 <210> 1324 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1324 gtgcccaaaa ctacagcggt 20 <210> 1325 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1325 ccacggccac acctgtgtct 20 <210> 1326 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1326 aacctgaagc ccaaacggtt 20 <210> 1327 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1327 gtcacctgtt ttactgagcc 20 <210> 1328 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1328 gggtgtttac ccaagacagc 20 <210> 1329 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1329 gtctgcgcac agctgagctt 20 <210> 1330 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1330 cacaattctc aaactgctcc 20 <210> 1331 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1331 ccgaagctct aatccctggc 20 <210> 1332 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1332 gttgctcaac tccagagaac 20 <210> 1333 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1333 tggcaagacc acgaagccaa 20 <210> 1334 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1334 cccaaagctc acaacactca 20 <210> 1335 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1335 gtggctcacc taccgtggcc 20 <210> 1336 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1336 ggctggcccc acagcaggc 20 <210> 1337 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1337 ccctggtgcc ttctacaggc 20 <210> 1338 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1338 cagcgactct gaacctctgc 20 <210> 1339 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1339 ctttaccctc ccaacaggtt 20 <210> 1340 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1340 ctccaggatc cctatgggct 20 <210> 1341 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1341 aggcaccacc agatgccaca 20 <210> 1342 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1342 cggtctttct cctcccacca 20 <210> 1343 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1343 aaaaactctc ctcactagcc 20 <210> 1344 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1344 ggctcagccc tttcagacct 20 <210> 1345 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1345 tgtcccagac catcatcgat 20 <210> 1346 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1346 acgcacccct ctcacatgcc 20 <210> 1347 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1347 gggaaacccc ccaagtcctc 20 <210> 1348 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1348 tcacccccca attcctacct 20 <210> 1349 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1349 tggacctcaa ccccctactt 20 <210> 1350 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1350 ccgcctgaat cccccacgcc 20 <210> 1351 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1351 gtgtccaaac tcacaggcta 20 <210> 1352 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1352 gtgcataaca caaatattgc 20 <210> 1353 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1353 accaagatta ccctcaggat 20 <210> 1354 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1354 gcacacccca tctcagtgac 20 <210> 1355 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1355 atgacaccca ttctggacat 20 <210> 1356 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1356 gcaccctccc tctactggca 20 <210> 1357 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1357 tctgctgtcc actcctgaac 20 <210> 1358 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1358 gctgcaattc aacactgcct 20 <210> 1359 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1359 cggaggctgc ccattagctg 20 <210> 1360 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1360 aaacaggtgc attctagggt 20 <210> 1361 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1361 acctggtgca cctggagtca 20 <210> 1362 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1362 gccctgctca gcacgaagcc 20 <210> 1363 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1363 tggacaggcc attcccactc 20 <210> 1364 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1364 gccccacacgc catacagtta 20 <210> 1365 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1365 ggacattccc agcattgacc 20 <210> 1366 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1366 cgaagctcta atccctggcc 20 <210> 1367 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1367 cacaggtaaa agacaggaca 20 <210> 1368 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1368 ggccgtgtcc tcccaagcct 20 <210> 1369 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1369 agtcttagcc accaaggcct 20 <210> 1370 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1370 ggacgggtcc ccatcttgcc 20 <210> 1371 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1371 gtgtttaccc aagacagcta 20 <210> 1372 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1372 cagggaaccc caccacatca 20 <210> 1373 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1373 acacccgtca ccctctgcac 20 <210> 1374 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1374 gtcccaggct tctcttggga 20 <210> 1375 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1375 gtgttctgtt ttacactaat 20 <210> 1376 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1376 gtgagatcca cactccagaa 20 <210> 1377 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1377 tgcccaaaac tacagcggtc 20 <210> 1378 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1378 cgccagggca gaattacctt 20 <210> 1379 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1379 gcaatgccca caaaggtggc 20 <210> 1380 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1380 gcagaagccc ccaactcact 20 <210> 1381 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1381 tcaaagctcc agctacacct 20 <210> 1382 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1382 ttgctcaact ccagagaacc 20 <210> 1383 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1383 ccttaattac ctctaaagaa 20 <210> 1384 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1384 tcccagtgcc tcacacgcgg 20 <210> 1385 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1385 cagctctatc ttcccagaca 20 <210> 1386 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1386 aagcttctcc tctctggaca 20 <210> 1387 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1387 tcacctgttt tactgagcct 20 <210> 1388 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1388 gccaccagct catttcactc 20 <210> 1389 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1389 ccactctacc ctctggcatc 20 <210> 1390 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1390 ggtgggctca ttattatagagc 20 <210> 1391 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1391 gcagcatcca aacccacggt 20 <210> 1392 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1392 caacagttct ccctgctgac 20 <210> 1393 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1393 tgcccatcca cccacttgga 20 <210> 1394 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1394 agagggtcca ccccagacag 20 <210> 1395 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1395 agcaggcctc cccattgtcc 20 <210> 1396 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1396 atctgcccag aacctcgcca 20 <210> 1397 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1397 gcagagggtc ccatgaggct 20 <210> 1398 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1398 cctgagcact cttacgcata 20 <210> 1399 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1399 ccccaaagtc tcccccctac 20 <210> 1400 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1400 cacagccacc tcaaagatga 20 <210> 1401 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1401 gcaggacaat ttctaggtac 20 <210> 1402 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1402 ttcccttaac cacctgtgca 20 <210> 1403 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1403 acagtccacc tagatggtcc 20 <210> 1404 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1404 cctgaccgac acctgtccca 20 <210> 1405 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1405 gcacggcccc atctgaactc 20 <210> 1406 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1406 agtccatccc agatgaccca 20 <210> 1407 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1407 gtgagctccc aactctgtcc 20 <210> 1408 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1408 gagcacacgc tcctatgcat 20 <210> 1409 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1409 cagagagact ccacctgtcc 20 <210> 1410 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1410 cccaggcccc atgtgtggtc 20 <210> 1411 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1411 accacaggct agaccaggct 20 <210> 1412 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1412 ctggacagtt caccccagat 20 <210> 1413 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1413 gtcttacttc ttaatggaga 20 <210> 1414 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1414 ggctgaggtt tctacaggcca 20 <210> 1415 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1415 aagctcacaa cactcagggt 20 <210> 1416 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1416 atattgccat tttaaccctc 20 <210> 1417 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1417 gcagagtccc accaccaaga 20 <210> 1418 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1418 aggccattcc cactcgctgt 20 <210> 1419 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1419 cccatccacc cacttggaca 20 <210> 1420 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1420 actctgtcca cttcctccac 20 <210> 1421 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1421 gaaagttgcc cactcctgta 20 <210> 1422 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1422 gggttcgccc ttactcatca 20 <210> 1423 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1423 ctgttttaca ctaatgcggg 20 <210> 1424 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1424 gcacccctct cacatgcccg 20 <210> 1425 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1425 aaactctcct cactagcctg 20 <210> 1426 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1426 agtgacactc aaaagtgctc 20 <210> 1427 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1427 ccaaggagac ctcactgctc 20 <210> 1428 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1428 tggctgaccc ccgccagggc 20 <210> 1429 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1429 gatgcgggcc aggctaggcc 20 <210> 1430 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1430 gccactctcc ctccaataga 20 <210> 1431 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1431 agacagtcca ccctggatga 20 <210> 1432 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1432 tctatcttcc cagaacacact 20 <210> 1433 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1433 tagtcataca cagatggcca 20 <210> 1434 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1434 cgggtcccca tcttgcctac 20 <210> 1435 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1435 gcaccgggca cagatcccac 20 <210> 1436 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1436 ccgggctccc atgaatgtcc 20 <210> 1437 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1437 gggctttgat atataaatct 20 <210> 1438 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1438 gccaaggaac atcagggcga 20 <210> 1439 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1439 tggccggaac acactttcac 20 <210> 1440 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1440 caggcctccc cattgtccat 20 <210> 1441 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1441 gccctagctt ccccagagca 20 <210> 1442 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1442 caagatacc ctcaggatca 20 <210> 1443 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1443 gtctgagacc catctgggtc 20 <210> 1444 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1444 tctctgccag ccctaactta 20 <210> 1445 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1445 agcacgagta ccctctgcca 20 <210> 1446 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1446 agctgctaaa agaaatgcca 20 <210> 1447 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1447 ctcaaccccc tacttggtct 20 <210> 1448 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1448 acccgtcacc ctctgcacca 20 <210> 1449 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1449 ctcacaggct actcccccca 20 <210> 1450 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1450 ggtcccctcc ttctcccatc 20 <210> 1451 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1451 acgctcctcc agctgagcct 20 <210> 1452 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1452 tgcaattcaa cactgcctta 20 <210> 1453 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1453 tttgaggaaa tctacgggta 20 <210> 1454 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1454 tgaatccccc acgccaggcc 20 <210> 1455 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1455 gctgtaccca caggcggcac 20 <210> 1456 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1456 acaggctcca ttgagaggct 20 <210> 1457 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1457 atgttaaata taaccacccc 20 <210> 1458 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1458 cccgcaccca cctctggtgc 20 <210> 1459 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1459 tggagtggag actcatccca 20 <210> 1460 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1460 actgagttca acaagatgaa 20 <210> 1461 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1461 gccccactca ccatgcagac 20 <210> 1462 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1462 gcggtctctt ctctctgttc 20 <210> 1463 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1463 gatgaattat tcccatgggc 20 <210> 1464 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1464 ccttggcatt cactgagcct 20 <210> 1465 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1465 tcctgacacc ccaccaacgc 20 <210> 1466 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1466 tgctgtccac tcctgaacac 20 <210> 1467 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1467 gtcttgttct ctgcgagaac 20 <210> 1468 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1468 gccacgcaga tcatgatgac 20 <210> 1469 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1469 ctcaaccgcc tcttctgcaa 20 <210> 1470 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1470 cacacggctc ctgtgagtca 20 <210> 1471 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1471 cccaggctca ttccccgccat 20 <210> 1472 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1472 cgaggcagaa ttctccattc 20 <210> 1473 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1473 tctacaggct ccttgcatgc 20 <210> 1474 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1474 gggaacccca ccacatcact 20 <210> 1475 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1475 gctcaactcc agagaaccaa 20 <210> 1476 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1476 accagctcat ttcactccgg 20 <210> 1477 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1477 caacaggttc tacctaccaa 20 <210> 1478 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1478 cgactctgaa cctctgcctc 20 <210> 1479 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1479 agggcagaat taccttgcaa 20 <210> 1480 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1480 tccacactcc agaagaacaa 20 <210> 1481 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1481 tctcatggct ctcattggcc 20 <210> 1482 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1482 cagttatgac tcaatgagcc 20 <210> 1483 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1483 tcctggttcc accatcaaga 20 <210> 1484 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1484 gcaaccctgc ccattgccag 20 <210> 1485 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1485 gggctggaca ccagccgacc 20 <210> 1486 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1486 caccaggcca accatccccc 20 <210> 1487 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1487 cttgccatcc cgaaattcca 20 <210> 1488 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1488 attttaaccc tctttgccgc 20 <210> 1489 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1489 tgcacatccc gatttggccc 20 <210> 1490 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1490 gtgatttgca tccagaattc 20 <210> 1491 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1491 tggtccctgc ccatagaggt 20 <210> 1492 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1492 ctccctccaa tagaacctca 20 <210> 1493 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1493 cactggctgt taaatttgct 20 <210> 1494 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1494 gtccacttcc tccaccgggc 20 <210> 1495 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1495 gtctctgtat atgcctggcc 20 <210> 1496 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1496 gcacagctcc catggatgaa 20 <210> 1497 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1497 ggtcccaggc ctctgagcgc 20 <210> 1498 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1498 ggtgccgaac cttaaggacc 20 <210> 1499 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1499 gcaggtccac cctccccccgc 20 <210> 1500 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1500 taaccgttcc cttccatgtc 20 <210> 1501 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1501 acctcactgc tcacaaggcc 20 <210> 1502 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1502 gccttcgcca tcgccaggct 20 <210> 1503 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1503 gggctcgcca cccctcatgc 20 <210> 1504 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1504 gctaatgaaa cagcctggtc 20 <210> 1505 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1505 cttggtttcc aatcatcatt 20 <210> 1506 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1506 ttggctcacc cagatcatcc 20 <210> 1507 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1507 aaccatggtc ctcctgggcc 20 <210> 1508 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1508 ctcttggttc acacaaccaa 20 <210> 1509 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1509 gggctgccac cctcactgaa 20 <210> 1510 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1510 gcccaagcac ttcacaccct 20 <210> 1511 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1511 gatggtccac actaaatggt 20 <210> 1512 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1512 cactatgcca ctaaggacac 20 <210> 1513 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1513 aggtaagcat ttaaaccttg 20 <210> 1514 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1514 atggaagccc ccttcaaccc 20 <210> 1515 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1515 tctcagggtc tccctggata 20 <210> 1516 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1516 agctcaggcc acccaagact 20 <210> 1517 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1517 tgcggaatcc cctcctgcac 20 <210> 1518 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1518 tctgttcacc tcacatgcat 20 <210> 1519 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1519 gggatggctt ctaatggcag 20 <210> 1520 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1520 cagggtcatc ctcgaagcca 20 <210> 1521 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1521 ccaccaagaa acatcgcaga 20 <210> 1522 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1522 gctccgcttg aatctaaaca 20 <210> 1523 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1523 gtctcccgcc ctgcctggtc 20 <210> 1524 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1524 cctgttggtc cttaactgaa 20 <210> 1525 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1525 accagcacag caaaggcaca 20 <210> 1526 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1526 ctttcactct ccatcgggtt 20 <210> 1527 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1527 gctggcccaa ctctagctga 20 <210> 1528 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1528 cacccttccc aaactcagct 20 <210> 1529 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1529 cacagttcaa tcccgaacac 20 <210> 1530 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1530 gccttgggct cttacccaca 20 <210> 1531 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1531 gctcaaacca tcaggaccca 20 <210> 1532 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1532 tcatttcact ccggcaggca 20 <210> 1533 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1533 ctcgctgtca acacacgaac 20 <210> 1534 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1534 tctgaagccc caaactagct 20 <210> 1535 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1535 gcatcagccc agagcacccc 20 <210> 1536 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1536 tgagctccac ctcatgccga 20 <210> 1537 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1537 ggtcgggcta tctaacccac 20 <210> 1538 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1538 gggtttgtca cacccttcac 20 <210> 1539 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1539 gcatgggaca atctccccca 20 <210> 1540 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1540 aggcagcact cactctacca 20 <210> 1541 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1541 tagagtccca gcacctgcct 20 <210> 1542 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1542 tacagcatta caatttgatc 20 <210> 1543 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1543 cccctctcac atgcccggct 20 <210> 1544 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1544 atggatggtc caccccagac 20 <210> 1545 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1545 aggaaaactc caatgctgcc 20 <210> 1546 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1546 tctgtcccca agctctgccg 20 <210> 1547 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1547 gagctggccc tccccccgca 20 <210> 1548 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1548 ggcctggttt ccctatttac 20 <210> 1549 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1549 cctgatgaaa cttcagccct 20 <210> 1550 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1550 ccagaagaac aaacctacca 20 <210> 1551 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1551 caaagcctct tccatttgac 20 <210> 1552 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1552 tacaaaccag taaggaacca 20 <210> 1553 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1553 tgagctcctc agcatgggcc 20 <210> 1554 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1554 ctggagacac catcttcgga 20 <210> 1555 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1555 tcagccttca ctcacacagt 20 <210> 1556 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1556 agtgggcatc cccatactgc 20 <210> 1557 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1557 ggctcagtgc ccttcaggga 20 <210> 1558 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1558 gctgctcacc ttttctagtt 20 <210> 1559 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1559 aggctactcc ccccaggcct 20 <210> 1560 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1560 gggaagctcc acaccagctc 20 <210> 1561 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1561 agttcctccc cagacaccgt 20 <210> 1562 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1562 catgtagtcc tcctcggcgc 20 <210> 1563 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1563 gcaaagctcc ctctggagga 20 <210> 1564 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1564 cacgataatt tcccatcttc 20 <210> 1565 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1565 tgaccctgcc ttcactgacc 20 <210> 1566 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1566 ggcatcagac cccaccccaa 20 <210> 1567 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1567 aaagcaggtc cccctgcacc 20 <210> 1568 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1568 ctgatgaaac ttcagccctc 20 <210> 1569 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1569 cgagaaggcc ctcttcttcc 20 <210> 1570 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1570 ggctcgccac ccctcatgca 20 <210> 1571 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1571 cactaaggac acatcaggc 20 <210> 1572 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1572 actggctgtt aaatttgcta 20 <210> 1573 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1573 aaccgttccc ttccatgtca 20 <210> 1574 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1574 ggctactccc cccaggcctc 20 <210> 1575 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1575 ccttcactca cacagtggcc 20 <210> 1576 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1576 ggcatctgtc ccacatggac 20 <210> 1577 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1577 ggtacggcct catccaggtc 20 <210> 1578 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1578 gtttgtcaca cccttcactt 20 <210> 1579 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1579 tccaatagaa cctcactgta 20 <210> 1580 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1580 gcggaatccc ctcctgcaca 20 <210> 1581 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1581 ggagtggaga ctcatcccac 20 <210> 1582 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1582 aggtccaccc tccccccgcaa 20 <210> 1583 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1583 agcatttaaa ccttggtgga 20 <210> 1584 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1584 cttggttcac acaaccaaat 20 <210> 1585 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1585 gtcgggctat ctaacccaca 20 <210> 1586 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1586 ctaatgaaac agcctggtca 20 <210> 1587 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1587 ctgttggtcc ttaactgaaa 20 <210> 1588 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1588 ccaagcactt cacaccctga 20 <210> 1589 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1589 aaagcctctt ccatttgacc 20 <210> 1590 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1590 ccggcaggca cagactggcc 20 <210> 1591 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1591 caccaagaaa catcgcagac 20 <210> 1592 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1592 tggaagcccc cttcaaccct 20 <210> 1593 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1593 gcacatgtcc ccctaaacgg 20 <210> 1594 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1594 acagcattac aatttgatca 20 <210> 1595 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1595 agcaaaggca caacaagatc 20 <210> 1596 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1596 ctgaagcccc aaactagctg 20 <210> 1597 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1597 ccctctcaca tgccccggctt 20 <210> 1598 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1598 ccttcccaaa ctcagctcca 20 <210> 1599 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1599 tcgctgtcaa cacacgaaca 20 <210> 1600 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1600 cagaagaaca aacctaccaa 20 <210> 1601 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1601 ctgagaggac tcagggactt 20 <210> 1602 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1602 ttgccatccc gaaattccaa 20 <210> 1603 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1603 agctggccct ccccccgcat 20 <210> 1604 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1604 ctttgaggcc ccttgacctc 20 <210> 1605 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1605 gagcggctat cccgctgccc 20 <210> 1606 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1606 aggctgtccc cttgtctcca 20 <210> 1607 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1607 ggcttgtcac cccaccgggc 20 <210> 1608 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1608 ggatggtcca ccccagacga 20 <210> 1609 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1609 gggccccacca tagccctgca 20 <210> 1610 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1610 gtgccgaacc ttaaggaccc 20 <210> 1611 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1611 gcctggtttc cctatttact 20 <210> 1612 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1612 atccagaatt ccagccgtac 20 <210> 1613 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1613 gtgggcatcc ccatactgcc 20 <210> 1614 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1614 tggccagctc ctcttgtctt 20 <210> 1615 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1615 tggagacacc atcttcggaa 20 <210> 1616 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1616 cgcttgagtc ataaagacgc 20 <210> 1617 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1617 caggcacccc actcactcga 20 <210> 1618 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1618 ggcagcactc actctaccac 20 <210> 1619 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1619 cttcgactca ccgtggctcc 20 <210> 1620 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1620 agctcctcag catgggcccc 20 <210> 1621 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1621 ccttgggctc ttacccacat 20 <210> 1622 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1622 ttttaaccct ctttgccgcc 20 <210> 1623 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1623 catgggacaa tctcccccaa 20 <210> 1624 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1624 catgcatgcc ttcatctaca 20 <210> 1625 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1625 accaggccaa ccatccccca 20 <210> 1626 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1626 gaggaagctc caatccaggt 20 <210> 1627 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1627 gaaccagcag caaaggacgc 20 <210> 1628 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1628 ttggtttcca atcatcattt 20 <210> 1629 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1629 caatcccgaa caccatgtca 20 <210> 1630 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1630 gcccaactct agctgatgcc 20 <210> 1631 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1631 gcagctcccc agccccagaa 20 <210> 1632 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1632 atggtccaca ctaaatggtc 20 <210> 1633 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1633 gccggagcca cctcctgcct 20 <210> 1634 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1634 gcagctcatc cctccgagaa 20 <210> 1635 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1635 ccacaggcca ccttgaggtg 20 <210> 1636 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1636 gccccccacc ttccagatct 20 <210> 1637 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1637 ccacggtgtc acaatcctgc 20 <210> 1638 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1638 gccgagctct tctctgtcca 20 <210> 1639 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1639 gggctatcta acccacagcc 20 <210> 1640 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1640 agcactcact ctaccacgga 20 <210> 1641 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1641 gcacttcaca ccctgaggca 20 <210> 1642 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1642 tcccgaaatt ccaaatcctc 20 <210> 1643 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1643 aggcacccca ctcactcgat 20 <210> 1644 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1644 gcttgagtca taaagacgca 20 <210> 1645 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1645 ccatcaggcc atctttgaca 20 <210> 1646 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1646 gatctgagcc cctcggtcca 20 <210> 1647 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1647 gcatggttcc ccgactcctc 20 <210> 1648 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1648 agtggagact catcccaccc 20 <210> 1649 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1649 gacttagccc catcagggcc 20 <210> 1650 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1650 cctggtttcc ctatttactg 20 <210> 1651 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1651 gcccatctcc ccatgcttgt 20 <210> 1652 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1652 ccccttgacc tcctcctggc 20 <210> 1653 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1653 cacatgtccc cctaaacggc 20 <210> 1654 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1654 tctccgcttc ctgtcagggc 20 <210> 1655 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1655 cggaaggaca ttcagagaaa 20 <210> 1656 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1656 ccgttccctt ccatgtcaca 20 <210> 1657 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1657 gtgaaattcc agaacaactt 20 <210> 1658 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1658 ggatgcggcc cactccccac 20 <210> 1659 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1659 gctcttctct gtccaaggcc 20 <210> 1660 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1660 ggcacaacaa gatccaggca 20 <210> 1661 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1661 ctcgccaccc ctcatgcata 20 <210> 1662 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1662 gaagaacaaa cctaccaagt 20 <210> 1663 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1663 ttgccggccc ttctgtggat 20 <210> 1664 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1664 cagctcatcc ctccgagaac 20 <210> 1665 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1665 gtcaacacac gaacagaacc 20 <210> 1666 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1666 actcagggac ttgccaagca 20 <210> 1667 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1667 tctttgccgc cctcttttaa 20 <210> 1668 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1668 cctggttttc ccccacggaa 20 <210> 1669 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1669 tttgtcacac ccttcacttt 20 <210> 1670 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1670 ggaagccccc ttcaaccctc 20 <210> 1671 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1671 gcatctgtcc cacatggacc 20 <210> 1672 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1672 gctagggatc ccaatgaaat 20 <210> 1673 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1673 aagcaggtcc ccctgcacct 20 <210> 1674 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1674 cgccgcccgg gatctcgcct 20 <210> 1675 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1675 tggtccacac taaatggtcc 20 <210> 1676 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1676 caggagggtc ctccaagcgg 20 <210> 1677 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1677 ggacaagctc cctcattgaa 20 <210> 1678 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1678 cttgtcaccc caccgggcat 20 <210> 1679 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1679 ctggctgtta aatttgctac 20 <210> 1680 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1680 gacctggaca caccaccctc 20 <210> 1681 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1681 gaggagggca cttatgcaat 20 <210> 1682 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1682 gcttcaggcc cactgccaac 20 <210> 1683 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1683 gtcttttctt tcaactgatc 20 <210> 1684 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1684 ctggccctcc ccccgcatga 20 <210> 1685 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1685 ggtttccaat catcattttc 20 <210> 1686 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1686 cttcactcac acagtggccg 20 <210> 1687 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1687 ccgtgtgccc ttaccgtagc 20 <210> 1688 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1688 aagcctcttc catttgacct 20 <210> 1689 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1689 gcttccccac caccagtgca 20 <210> 1690 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1690 cttgggctct tacccacata 20 <210> 1691 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1691 ggcatcccca tactgccccc 20 <210> 1692 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1692 aaggcggcca ctcccttccc 20 <210> 1693 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1693 acaatttgat caaccacagc 20 <210> 1694 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1694 caatagaacc tcactgtata 20 <210> 1695 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1695 agaaggccct cttcttccgc 20 <210> 1696 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1696 gacaatctcc cccaaagcgg 20 <210> 1697 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1697 cacggtgtca caatcctgca 20 <210> 1698 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1698 taaggacaca ttcaggctcc 20 <210> 1699 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1699 atcgcagacc cacctgccac 20 <210> 1700 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1700 acgataattt cccatcttca 20 <210> 1701 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1701 ccaggatccc agcataagac 20 <210> 1702 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1702 ggtggagtaa aaacaatgat 20 <210> 1703 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1703 ggtacagcct gaaactggcc 20 <210> 1704 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1704 cggagccacc tcctgcctga 20 <210> 1705 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1705 gatggtccac cccagacgat 20 <210> 1706 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1706 agctaagtcc cctccctgtc 20 <210> 1707 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1707 ccaggccaac catccccccac 20 <210> 1708 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1708 gttcacacaa ccaaatgtta 20 <210> 1709 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1709 tgcatgcctt catctacacc 20 <210> 1710 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1710 gtctcagatt cacaatcccg 20 <210> 1711 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1711 cggcaggcac agactggccc 20 <210> 1712 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1712 gctcagggcc tcctgatgca 20 <210> 1713 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1713 atgcccggct tccccgggcc 20 <210> 1714 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1714 gaggaccccc tttcttgctg 20 <210> 1715 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1715 caccgtcacc ctccccgggca 20 <210> 1716 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1716 catggttccc cgactcctcc 20 <210> 1717 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1717 ttccatgtca cagacgcggc 20 <210> 1718 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1718 aggcggccac tcccttccca 20 <210> 1719 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1719 gccaacccct ccacttccga 20 <210> 1720 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1720 atggtgagta gagtgtgcca 20 <210> 1721 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1721 gcggctgatc ccctcctcca 20 <210> 1722 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1722 gcatgccttc atctacacct 20 <210> 1723 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1723 caggtgaaca cagtcagctc 20 <210> 1724 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1724 acttagcccc atcagggcct 20 <210> 1725 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1725 gcctccacct ttccccactga 20 <210> 1726 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1726 ctggtttccc tatttactga 20 <210> 1727 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1727 gtctcttgcc ctgacaggcc 20 <210> 1728 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1728 tcacggaccc tcctccatgc 20 <210> 1729 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1729 agggatccca atgaaataca 20 <210> 1730 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1730 gggacaagcc tcccacagac 20 <210> 1731 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1731 caggatccca gcataagact 20 <210> 1732 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1732 cccgaaattc caaatcctcc 20 <210> 1733 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1733 gaggatttcc cacgacatct 20 <210> 1734 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1734 cgtctgctcc tatcagtcgg 20 <210> 1735 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1735 cggcgaattc cccggagcct 20 <210> 1736 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1736 tcgccacccc tcatgcatac 20 <210> 1737 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1737 caggccaacc atcccccacc 20 <210> 1738 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1738 agcctcttcc atttgaccta 20 <210> 1739 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1739 tggagactca tccccacccca 20 <210> 1740 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1740 gccctgtccc cccattgggc 20 <210> 1741 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1741 gggctaggaa gaacctgcct 20 <210> 1742 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1742 acactgtgat ccaaaatgaa 20 <210> 1743 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1743 gtttgtgaat caccataacc 20 <210> 1744 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1744 gtcacaccct tcactttgtc 20 <210> 1745 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1745 aacaaaccta ccaagtcctc 20 <210> 1746 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1746 catcaggcca tctttgacac 20 <210> 1747 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1747 aatggtccat cccagaaggt 20 <210> 1748 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1748 caacagcctt ctctgagccg 20 <210> 1749 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1749 cggtgtcaca atcctgcagc 20 <210> 1750 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1750 ggcagggcca cctcgcccct 20 <210> 1751 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1751 tggacacacc accctccacc 20 <210> 1752 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1752 gagtcggtca ccagaaaggc 20 <210> 1753 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1753 tgcccggctt ccccgggccc 20 <210> 1754 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1754 ttgggctctt acccacatac 20 <210> 1755 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1755 gaaggccctc ttcttccgct 20 <210> 1756 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1756 cacttatgca atcccaggct 20 <210> 1757 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1757 gacaagctcc ctcattgaat 20 <210> 1758 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1758 agctcatccc tccgagaaca 20 <210> 1759 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1759 ggcaccccac tcactcgatc 20 <210> 1760 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1760 gtacagcctg aaactggcca 20 <210> 1761 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1761 gctaagtccc ctccctgtcc 20 <210> 1762 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1762 cggccacgcc ttacttgtcc 20 <210> 1763 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1763 cactgtatac ttcatttcca 20 <210> 1764 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1764 gggctggtcc ccaaagacat 20 <210> 1765 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1765 accgtcaccc tccggggcat 20 <210> 1766 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1766 cacacgaaca gaacctgcac 20 <210> 1767 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1767 gacatgtgcc cacaccaggc 20 <210> 1768 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1768 ggctatctaa cccacagccc 20 <210> 1769 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1769 taatttccca tcttcaaggc 20 <210> 1770 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1770 cagggacttg ccaagcagtc 20 <210> 1771 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1771 ctggttttcc cccacggaac 20 <210> 1772 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1772 ggacacttcc actggaggat 20 <210> 1773 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1773 cgtgtgccct taccgtagcc 20 <210> 1774 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1774 cccctcggtc cagaatggcc 20 <210> 1775 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1775 gttcagttcc ctgctgcctc 20 <210> 1776 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1776 ccgccctctt ttaaggactt 20 <210> 1777 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1777 ttgctgagaa gatcctctct 20 <210> 1778 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1778 cccttgacct cctcctggca 20 <210> 1779 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1779 ttcacacaac caaatgttat 20 <210> 1780 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1780 tcgcagaccc acctgccacc 20 <210> 1781 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1781 aggatgagtc ctcatttgca 20 <210> 1782 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1782 aatttgatca accacagcca 20 <210> 1783 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1783 caactgatcc actttcccct 20 <210> 1784 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1784 catctgtccc acatggaccc 20 <210> 1785 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1785 ttcaggccca ctgccaaccc 20 <210> 1786 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1786 caggaaacaa gaaccacgac 20 <210> 1787 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1787 ggagtgtccc agaaagtgca 20 <210> 1788 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1788 cccaacccac atcacagtgt 20 <210> 1789 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1789 gaagccccct tcaaccctcc 20 <210> 1790 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1790 gctgtggtga ctcactgcca 20 <210> 1791 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1791 tccaccccag acgatccacc 20 <210> 1792 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1792 ggttcattcc agactggagc 20 <210> 1793 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1793 ccctgtcccc ccattgggca 20 <210> 1794 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1794 aggatttccc acgacatctt 20 <210> 1795 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1795 ggttttcccc cacggaaccc 20 <210> 1796 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1796 tcagtcggct gccttagccc 20 <210> 1797 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1797 aggccaacca tccccccacca 20 <210> 1798 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1798 gccggctgtc caccttgacc 20 <210> 1799 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1799 ttgttgcaaa ctaagtgccc 20 <210> 1800 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1800 ccagacagtc catcctagat 20 <210> 1801 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1801 tccatttgac ctacacttta 20 <210> 1802 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1802 ccaaagacat gactcaggac 20 <210> 1803 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1803 gcaccccact cactcgatct 20 <210> 1804 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1804 tccctgtccc atcctataga 20 <210> 1805 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1805 ttgacacggg caaccaggac 20 <210> 1806 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1806 gaggagcttc aatctatgcc 20 <210> 1807 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1807 ggtctggccc tctaccccca 20 <210> 1808 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1808 ggagcctgcc ctactcatct 20 <210> 1809 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1809 tgtgaatcac cataaccaga 20 <210> 1810 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1810 cagggatctg tctctatttc 20 <210> 1811 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1811 gtggctggaa catctccggt 20 <210> 1812 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1812 agtcggtcac cagaaaggca 20 <210> 1813 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1813 ggacaagcct cccacagacc 20 <210> 1814 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1814 ggtgtcacaa tcctgcagcc 20 <210> 1815 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1815 tgctgcctcc agtcacttca 20 <210> 1816 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1816 acagcccccc catcatctca 20 <210> 1817 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1817 atttgatcaa ccacagccac 20 <210> 1818 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1818 gttccccgac tcctcctcga 20 <210> 1819 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1819 tctggtagaa tattccattc 20 <210> 1820 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1820 gctatctaac ccacagcccc 20 <210> 1821 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1821 ggtagggccc tcactgctgc 20 <210> 1822 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1822 acttatgcaa tcccaggctc 20 <210> 1823 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1823 ggccgacaca tccgtgggac 20 <210> 1824 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1824 ggctgcacta acccaggaca 20 <210> 1825 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1825 caccccagac gatccacccc 20 <210> 1826 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1826 aaggccctct tcttccgctt 20 <210> 1827 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1827 ccttgacctc ctcctggcac 20 <210> 1828 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1828 gctgagaaga tcctctctct 20 <210> 1829 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1829 cacacagaac caccaggtcc 20 <210> 1830 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1830 tgactcctcc acccagaccc 20 <210> 1831 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1831 gggccagcta ttctgagcct 20 <210> 1832 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1832 cccgtgtgtc ctcacagtcc 20 <210> 1833 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1833 ccctcggtcc agaatggcct 20 <210> 1834 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1834 cgactgagat tctaacgcga 20 <210> 1835 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1835 gttttgggcc aggatggcct 20 <210> 1836 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1836 cccggcttcc ccgggccctt 20 <210> 1837 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1837 aacaagaacc accacagggc 20 <210> 1838 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1838 tcccaatgaa atacatgaca 20 <210> 1839 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1839 cccttcaacc ctcctgtgga 20 <210> 1840 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1840 gccgagccca ggaaatgcct 20 <210> 1841 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1841 gagtgtccca gaaagtgcac 20 <210> 1842 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1842 cagttgtccc agactggcca 20 <210> 1843 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1843 gtcagcatcc tgatttccct 20 <210> 1844 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1844 acaagctccc tcattgaata 20 <210> 1845 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1845 agggacttgc caagcagtcc 20 <210> 1846 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1846 tgggctctta cccacatact 20 <210> 1847 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1847 gagtttggac cccctaggtc 20 <210> 1848 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1848 tgtggactca ccagttgatc 20 <210> 1849 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1849 cgcagaccca cctgccacca 20 <210> 1850 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1850 gccagaggct ctactcccgg 20 <210> 1851 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1851 ccaacccaca tcacagtgtc 20 <210> 1852 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1852 ccgaaattcc aaatcctcct 20 <210> 1853 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1853 cggccactcc cttcccaggt 20 <210> 1854 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1854 gcagaagaat ctacttcctg 20 <210> 1855 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1855 agaacctgca cccgaagccg 20 <210> 1856 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1856 aatttcccat cttcaaggcc 20 <210> 1857 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1857 gtagaagcct caactagttt 20 <210> 1858 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1858 tcacaccctt cactttgtcc 20 <210> 1859 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1859 ccaacccctc cacttccgat 20 <210> 1860 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1860 ctgtatactt catttccaac 20 <210> 1861 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1861 ggatgagtcc tcatttgcaa 20 <210> 1862 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1862 acggaccctc ctccatgccc 20 <210> 1863 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1863 atctgtccca catggacccc 20 <210> 1864 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1864 cgagccccca cagccatggc 20 <210> 1865 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1865 acagagccct ccatgtagta 20 <210> 1866 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1866 gtctgattca tcctcatttc 20 <210> 1867 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1867 gtttccctat ttactgagcc 20 <210> 1868 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1868 gccttcatct acacctgcac 20 <210> 1869 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1869 ccgtgtgtcc tcacagtcct 20 <210> 1870 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1870 ccttcatcta cacctgcaca 20 <210> 1871 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1871 gcctccagtc acttcacctc 20 <210> 1872 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1872 tttgatcaac cacagccaca 20 <210> 1873 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1873 ctgagaagat cctctctctc 20 <210> 1874 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1874 cccaccctgc ttcaaggcct 20 <210> 1875 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1875 tggacatcca tctatcatcc 20 <210> 1876 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1876 gctgagagga ctcagggact 20 <210> 1877 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1877 cctcactccc gcccttgcct 20 <210> 1878 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1878 ggatctgtct ctatttcttc 20 <210> 1879 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1879 cacatggacc ccagcaccat 20 <210> 1880 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1880 cccaatgaaa tacatgacac 20 <210> 1881 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1881 cagcccccccc atcatctcac 20 <210> 1882 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1882 cagttgctcc ttccttgcca 20 <210> 1883 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1883 gctgcactaa cccaggacaa 20 <210> 1884 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1884 tgccctgtac cccatgggcc 20 <210> 1885 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1885 aaagggcaca cacatgtctc 20 <210> 1886 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1886 tgacagttca ctccagatga 20 <210> 1887 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1887 ccagatgcta tcctcatgga 20 <210> 1888 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1888 atcctgattt ccctcattgt 20 <210> 1889 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1889 gtggagtgcc ccagaacggc 20 <210> 1890 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1890 cccacggaac ccctctcagc 20 <210> 1891 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1891 tttccctatt tactgagcct 20 <210> 1892 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1892 tggctggaac atctccggtt 20 <210> 1893 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1893 ggccactccc ttcccaggtg 20 <210> 1894 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1894 atttcccatc ttcaaggccc 20 <210> 1895 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1895 tcttgttgtc ctcccgcttc 20 <210> 1896 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1896 aaatcctcct gataatcctc 20 <210> 1897 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1897 aggtgatgcc ccacaagaca 20 <210> 1898 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1898 ccagacgatc caccccagat 20 <210> 1899 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1899 agaatattcc attccccgca 20 <210> 1900 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1900 cccactgcaa catctttccc 20 <210> 1901 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1901 gtgaatcacc ataaccagac 20 <210> 1902 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1902 gagctcctca gcatgggccc 20 <210> 1903 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1903 gactcctcca cccagaccct 20 <210> 1904 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1904 agaatctact tcctgtgtcc 20 <210> 1905 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1905 gagtgtgcca tccccagggt 20 <210> 1906 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1906 cacagtgtcc cccacgggca 20 <210> 1907 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1907 gtgagctgaa atatcatgcc 20 <210> 1908 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1908 ctatctaacc cacagccccc 20 <210> 1909 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1909 gacgcaggca tcccactcat 20 <210> 1910 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1910 ccctggcccc tctagcacca 20 <210> 1911 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1911 agctccctca ttgaataatt 20 <210> 1912 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1912 ccggctgtcc accttgaccc 20 <210> 1913 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1913 ttccccacgac atcttttgca 20 <210> 1914 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1914 ccattgggca cttttactca 20 <210> 1915 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1915 ggcaccccag aaacaagagc 20 <210> 1916 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1916 gtgcaccgac acattctgga 20 <210> 1917 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1917 ttccccgggc cctttgctgc 20 <210> 1918 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1918 gtgtcacaat cctgcagcca 20 <210> 1919 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1919 gacaagcctc ccacagacca 20 <210> 1920 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1920 tccccgactc ctcctcgaac 20 <210> 1921 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1921 cctcggccca atctgaactt 20 <210> 1922 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1922 ttgagccgct ccttgaaggt 20 <210> 1923 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1923 cctgccctac tcatctcagc 20 <210> 1924 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1924 tcaggacctt ccagagattt 20 <210> 1925 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1925 cctgtcccat cctatagaca 20 <210> 1926 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1926 aggagcttca atctatgcct 20 <210> 1927 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1927 agggatgatt ctagaaggcc 20 <210> 1928 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1928 ccatttcatt tccaggctta 20 <210> 1929 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1929 ttcatcctca tttcccccgc 20 <210> 1930 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1930 ccgaagccgt cacctccctc 20 <210> 1931 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1931 gggctcaccc ctcacctggt 20 <210> 1932 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1932 ggccaaccat cccccaccaa 20 <210> 1933 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1933 tccccaagca ccacatgacc 20 <210> 1934 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1934 aatggcctca ccttgagatc 20 <210> 1935 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1935 tgctcgctca cagcctgcca 20 <210> 1936 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1936 ccaggtggtt cctcctgcca 20 <210> 1937 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1937 aggcttctcc atgtgaagct 20 <210> 1938 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1938 atttgaccta catcttagct 20 <210> 1939 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1939 ggctcttacc cacatacttg 20 <210> 1940 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1940 caacccctcc acttccgatt 20 <210> 1941 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1941 gacatgactc aggacaggcc 20 <210> 1942 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1942 agtttggacc ccctaggtcc 20 <210> 1943 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1943 ctgagattct aacgcgagcc 20 <210> 1944 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1944 cctgaggcca cacgcagaca 20 <210> 1945 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1945 aaggtggttg caacctgcac 20 <210> 1946 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1946 tgctgatgtc ccctgggacc 20 <210> 1947 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1947 gtccctgtca cacaactgcc 20 <210> 1948 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1948 aggtggttcc tcctgccaga 20 <210> 1949 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1949 gagtttgtcc ccagtgctca 20 <210> 1950 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1950 gggcctccta ctcacccacc 20 <210> 1951 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1951 gcctaggacc ccctgacagc 20 <210> 1952 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1952 tgctccttcc ttgccaagct 20 <210> 1953 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1953 tgccctactc atctcagcgc 20 <210> 1954 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1954 accttgagat cctcaactaa 20 <210> 1955 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1955 gcctggttat gaaatgcgca 20 <210> 1956 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1956 tgagattcta acgcgagccg 20 <210> 1957 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1957 cctgcagatt cacctctgta 20 <210> 1958 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1958 gcaacatctt tccctcactc 20 <210> 1959 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1959 tgttttgaca cccttgggcc 20 <210> 1960 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1960 acctcaggct cctgtaccct 20 <210> 1961 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1961 cagatgctat cctcatggat 20 <210> 1962 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1962 ctggagagga cccacagcca 20 <210> 1963 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1963 gccctggtca ccgacagcct 20 <210> 1964 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1964 cacgcaggtc ccagcagctc 20 <210> 1965 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1965 agttcactcc agatgatcca 20 <210> 1966 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1966 atgggccccc tgcccagtgc 20 <210> 1967 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1967 acggagtccc aggaaaacaa 20 <210> 1968 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1968 tgcaccgaca cattctggaa 20 <210> 1969 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1969 ccacggaacc cctctcagca 20 <210> 1970 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1970 cgatccaccc cagatggtcc 20 <210> 1971 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1971 ttgaataatt aatcaaggac 20 <210> 1972 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1972 cctcatccat aaacaggcag 20 <210> 1973 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1973 tcaccgcgcc atgactgcac 20 <210> 1974 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1974 aaggagagtc ccccttttta 20 <210> 1975 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1975 gcaggcatcc cactcatgaa 20 <210> 1976 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1976 ccccccatca tctcacagtc 20 <210> 1977 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1977 agagtgcccc atcatgccct 20 <210> 1978 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1978 gcactaaccc aggacaacaa 20 <210> 1979 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1979 cccaagcacc accagaccca 20 <210> 1980 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1980 ctgatttccc tcattgttgc 20 <210> 1981 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1981 ggagcttcaa tctatgcctc 20 <210> 1982 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1982 ttccccggtcc tctacaggtc 20 <210> 1983 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1983 tgaatcacca taaccagacc 20 <210> 1984 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1984 ccccgactcc tcctcgaacc 20 <210> 1985 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1985 tttgacctac atcttagctg 20 <210> 1986 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1986 ccacccagac cctccgacct 20 <210> 1987 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1987 ttccagagat ttcctcctgc 20 <210> 1988 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1988 gaagccgtca cctccctccc 20 <210> 1989 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1989 acagtgtccc ccacgggcat 20 <210> 1990 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1990 ctagaaggcc ctcagcacac 20 <210> 1991 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1991 cacgcagaca ccaagggcac 20 <210> 1992 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1992 cggctgtcca ccttgaccct 20 <210> 1993 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1993 ctgtcccatc ctatagacac 20 <210> 1994 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1994 ctgtgtccat tctcatccac 20 <210> 1995 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1995 ccttcactga ctatgtgcct 20 <210> 1996 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1996 atcgagtcat ctgggagccc 20 <210> 1997 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1997 gcacggaaca tgcttagggc 20 <210> 1998 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1998 tgagaggact cagggacttg 20 <210> 1999 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1999 cccacctgca cagatggcac 20 <210> 2000 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2000 gtgtgccatc cccagggtca 20 <210> 2001 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2001 ctccacttcc gattctgtcc 20 <210> 2002 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2002 gagaagatcc tctctctcca 20 <210> 2003 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2003 ccaatgaaat acatgacaca 20 <210> 2004 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2004 cttcaaggcc ctccacttaa 20 <210> 2005 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2005 gcacacgcca tacctgggca 20 <210> 2006 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2006 ggctcacccc tcacctggtc 20 <210> 2007 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2007 ccctaggtcc cttctcggat 20 <210> 2008 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2008 cctccagtca cttcacctct 20 <210> 2009 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2009 ttgggcactt ttactcaaaa 20 <210> 2010 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2010 tcatcctcat ttcccccgca 20 <210> 2011 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2011 cctgactgac ttcttccaac 20 <210> 2012 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2012 gctcttaccc acatacttgt 20 <210> 2013 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2013 tcccacgaca tcttttgcag 20 <210> 2014 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2014 tcagaagcac ccagaagccg 20 <210> 2015 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2015 gttttaagac ccccttttta 20 <210> 2016 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2016 tggatcagac acccatgccg 20 <210> 2017 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2017 ggacgaagct tcctcttgcc 20 <210> 2018 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2018 ggacatccat ctatcatcca 20 <210> 2019 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2019 tgtgtcctca cagtcctcca 20 <210> 2020 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2020 tgataatcct ctcctccccc 20 <210> 2021 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2021 tccccgggcc ctttgctgct 20 <210> 2022 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2022 acccgcttcc ctcacagagc 20 <210> 2023 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2023 ctcagggact tgccaagcag 20 <210> 2024 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2024 ctagctagca cacacagcca 20 <210> 2025 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2025 cccagaccct ccgaccttta 20 <210> 2026 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2026 gggctgcccg tattcttcct 20 <210> 2027 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2027 ggtggttcct cctgccagac 20 <210> 2028 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2028 gtatggtcca cctaaatggt 20 <210> 2029 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2029 ggaggctgaa ttgtgcttca 20 <210> 2030 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2030 acccaggaca acaaacaagc 20 <210> 2031 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2031 gagcttcaat ctatgcctca 20 <210> 2032 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2032 acgcctctcc tctgtgtgcc 20 <210> 2033 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2033 gccctactca tctcagcgcg 20 <210> 2034 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2034 cctctggaaa gaatgtgcct 20 <210> 2035 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2035 ggtccgagca tcagaatcaa 20 <210> 2036 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2036 gatgctatcc tcatggatgc 20 <210> 2037 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2037 gccctcagca caccgagtca 20 <210> 2038 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2038 ggcgggatca tcctctgcca 20 <210> 2039 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2039 agagtaggtc ccagcagccg 20 <210> 2040 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2040 tgtgtccatt ctcatccact 20 <210> 2041 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2041 agggtcacgc tagtgccacc 20 <210> 2042 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2042 gccccaggca ccattaggcg 20 <210> 2043 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2043 gcaccgacac attctggaaa 20 <210> 2044 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2044 ttgacctaca tcttagctga 20 <210> 2045 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2045 gccagagaca ttaatgaagc 20 <210> 2046 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2046 accagagcca tcagcaggtc 20 <210> 2047 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2047 ccccgggccc tttgctgctt 20 <210> 2048 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2048 gaaagaccca tccccagaga 20 <210> 2049 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2049 tggaccagct cctcctcaaa 20 <210> 2050 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2050 gtgctgtccc agcttgagca 20 <210> 2051 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2051 ccgattctgt cctccagggc 20 <210> 2052 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2052 tctggaagac tccgcagctc 20 <210> 2053 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2053 cgactcctcc tcgaaccttc 20 <210> 2054 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2054 tctgccgtcc cctccagcac 20 <210> 2055 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2055 tccctgtcac acaactgcca 20 <210> 2056 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2056 gtcccatcct atagacacca 20 <210> 2057 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2057 cccacgacat cttttgcagc 20 <210> 2058 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2058 cccccatcat ctcacagtct 20 <210> 2059 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2059 cctgacccca ccactgaagc 20 <210> 2060 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2060 cccaggaccc ccccatggtc 20 <210> 2061 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2061 gcgagggcca caacacagta 20 <210> 2062 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2062 gttttgacac ccttgggcct 20 <210> 2063 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2063 ggtcccctac tactaagcc 20 <210> 2064 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2064 aggatgcatt ccatccagat 20 <210> 2065 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2065 tgcagattca cctctgtatt 20 <210> 2066 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2066 accgacagcc tctgtggccc 20 <210> 2067 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2067 atacatgaca cacctggtga 20 <210> 2068 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2068 agaccccctt tttacaaatc 20 <210> 2069 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2069 gactgacttc ttccaacttt 20 <210> 2070 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2070 ggcatcccac tcatgaaggc 20 <210> 2071 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2071 gcaccggcaa cttcaggtac 20 <210> 2072 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2072 gtctcagccc tgcttagggc 20 <210> 2073 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2073 accccacccc acatggtggt 20 <210> 2074 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2074 cccaaactca caccagaagc 20 <210> 2075 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2075 acaggtctta atctctggac 20 <210> 2076 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2076 caaggccctc cacttaatca 20 <210> 2077 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2077 ggatcagaca cccatgccgg 20 <210> 2078 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2078 ctcttaccca catacttgtc 20 <210> 2079 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2079 gcggctcgct cacatccct 20 <210> 2080 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2080 gacgaagctt cctcttgcct 20 <210> 2081 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2081 caccataacc agacccggca 20 <210> 2082 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2082 gcaatggacc cactgagttt 20 <210> 2083 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2083 ggatggccca ccccagacaa 20 <210> 2084 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2084 ccagagattt cctcctgctt 20 <210> 2085 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2085 gcacagtgtc ttccagggcc 20 <210> 2086 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2086 aacatctttc cctcactcgc 20 <210> 2087 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2087 ctccagtcac ttcacctctt 20 <210> 2088 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2088 cgtgcaacat tttcaagcct 20 <210> 2089 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2089 gctaaccccc acatcagagc 20 <210> 2090 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2090 cccgcttccc tcacagagcc 20 <210> 2091 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2091 gagagtcccc ctttttagga 20 <210> 2092 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2092 caccacatga cccacaggca 20 <210> 2093 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2093 acgggcatcc ttgtgtgccc 20 <210> 2094 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2094 cacggaaccc ctctcagcac 20 <210> 2095 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2095 cttgagatcc tcaactaatc 20 <210> 2096 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2096 gctgtccacc ttgacccttc 20 <210> 2097 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2097 cattgttgcc cacccattcc 20 <210> 2098 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2098 accatctgct catcatccat 20 <210> 2099 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2099 atcctcattt ccccgcagc 20 <210> 2100 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2100 ctgctcatca tccatccact 20 <210> 2101 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2101 ggtcacgcta gtgccaccgt 20 <210> 2102 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2102 tgaattgtgc ttcacaagtc 20 <210> 2103 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2103 ccaggactgt tcactgctct 20 <210> 2104 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2104 gtgcaacatt ttcaagcctc 20 <210> 2105 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2105 accccctttt tacaaatctt 20 <210> 2106 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2106 cgagcatcag aatcaataac 20 <210> 2107 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2107 cgggagccac agtctccaca 20 <210> 2108 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2108 gatgtttctt ccctctgacc 20 <210> 2109 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2109 acggaacccc tctcagcaca 20 <210> 2110 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2110 aggagcctca cttgttgtcc 20 <210> 2111 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2111 ggatgcattc catccagata 20 <210> 2112 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2112 cctcctcgaa ccttcacggc 20 <210> 2113 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2113 ttttccggca tttctgcttt 20 <210> 2114 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2114 gccttttcta agaaaactcc 20 <210> 2115 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2115 accttgaccc ttccctgcac 20 <210> 2116 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2116 gagatcctca actaatcaca 20 <210> 2117 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2117 ccccaggcac cattaggcgg 20 <210> 2118 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2118 tcttacccac atacttgtcc 20 <210> 2119 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2119 cgaagcttcc tcttgcctgc 20 <210> 2120 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2120 gaccctccga cctttactcc 20 <210> 2121 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2121 gcagggctgt tcctagagac 20 <210> 2122 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2122 cttgtgtgcc ctccaccagc 20 <210> 2123 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2123 ggcaggtcag catcacagac 20 <210> 2124 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2124 aaggccctcc acttaatcat 20 <210> 2125 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2125 gaggagagat cacacaggct 20 <210> 2126 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2126 ctgaattgca cccccagatt 20 <210> 2127 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2127 gaggcgagct ttacactttt 20 <210> 2128 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2128 catggatgcc ccaatctgcc 20 <210> 2129 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2129 ctgaccccac cactgaagcc 20 <210> 2130 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2130 gcgggatcat cctctgccag 20 <210> 2131 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2131 gggccatccc cacttgactt 20 <210> 2132 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2132 gtcagccaga tatcaaggca 20 <210> 2133 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2133 gacttcttcc aactttccaa 20 <210> 2134 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2134 gctgagcccc cacatgcac 20 <210> 2135 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2135 ccagagacat taatgaagcc 20 <210> 2136 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2136 ccagacgcac catcacccaa 20 <210> 2137 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2137 cccgggccct ttgctgcttc 20 <210> 2138 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2138 tctgacagtc atatttaacc 20 <210> 2139 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2139 ccctactcat ctcagcgcga 20 <210> 2140 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2140 acatctttcc ctcactcgcc 20 <210> 2141 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2141 agcagccgcc acttctcgaa 20 <210> 2142 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2142 gagtgtggaa aatctagttt 20 <210> 2143 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2143 ctcggcataa cacatggccc 20 <210> 2144 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2144 agtttccccc tccatacaac 20 <210> 2145 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2145 ccgccgtctt tctctctgaa 20 <210> 2146 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2146 taagcaccag cctaacccct 20 <210> 2147 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2147 attgttgccc acccattcca 20 <210> 2148 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2148 ggtccgagca ccacagtgcc 20 <210> 2149 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2149 ctcgctcaca ttccctggga 20 <210> 2150 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2150 cagggtagcc ctgccaagca 20 <210> 2151 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2151 agatgcttcc ccctgcccgc 20 <210> 2152 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2152 accaggcacc ccagttgccc 20 <210> 2153 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2153 ggatacttcc aggagaccca 20 <210> 2154 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2154 ccccggctta caatcatgtt 20 <210> 2155 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2155 ctaaccccca catcagagct 20 <210> 2156 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2156 cagagggacc tctctctttt 20 <210> 2157 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2157 tccaggtaat aatatactct 20 <210> 2158 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2158 ctggtttcct cctgagcaca 20 <210> 2159 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2159 ccctgatgat ctaccccaga 20 <210> 2160 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2160 agacgcagcc cactcggata 20 <210> 2161 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2161 ctgccgctcc atccagaggt 20 <210> 2162 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2162 ccagacccgg caaaacactc 20 <210> 2163 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2163 gagccaggtc cccttccctc 20 <210> 2164 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2164 ccaaactcac accagaagcc 20 <210> 2165 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2165 atggtccacc taaatggtcc 20 <210> 2166 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2166 tcctgcaaat caccagagtc 20 <210> 2167 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2167 cctcatttcc ccccgcagcat 20 <210> 2168 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2168 gctcccgtaa caaatgaccg 20 <210> 2169 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2169 gcccccccat agcttggcca 20 <210> 2170 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2170 gggtccctgt ttactgatcc 20 <210> 2171 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2171 tcagacaccc atgccgggcc 20 <210> 2172 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2172 ggctgcccgt attcttcctg 20 <210> 2173 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2173 ccgagagcgc atcccagctc 20 <210> 2174 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2174 gcagattcac ctctgtattc 20 <210> 2175 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2175 tccagcggtc cacctcctaa 20 <210> 2176 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2176 gtgtccattc tcatccactc 20 <210> 2177 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2177 cccctccata caacagggac 20 <210> 2178 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2178 gagggacctc tctcttttaa 20 <210> 2179 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2179 ctgacagtca tattaacca 20 <210> 2180 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2180 gcttaggaac ccaccctccc 20 <210> 2181 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2181 tcagccagat atcaaggcaa 20 <210> 2182 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2182 agcaccagcc taacccctgt 20 <210> 2183 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2183 ctcctgagca cagatcgccg 20 <210> 2184 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2184 ggagagactc ctctcacaca 20 <210> 2185 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2185 acggcggcac acactatagc 20 <210> 2186 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2186 tgaccccacc actgaagcca 20 <210> 2187 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2187 ccagcatata ttcaatcaac 20 <210> 2188 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2188 agatcctcaa ctaatcacat 20 <210> 2189 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2189 atgtttcttc cctctgacct 20 <210> 2190 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2190 tgtccattct catccactca 20 <210> 2191 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2191 tcggcataac acatggcccc 20 <210> 2192 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2192 tgttccccca ccctgaatcc 20 <210> 2193 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2193 accctccgac ctttactcca 20 <210> 2194 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2194 acgctagtgc caccgtgtcc 20 <210> 2195 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2195 cccccttttt acaaatcttc 20 <210> 2196 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2196 cttacccaca tacttgtcca 20 <210> 2197 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2197 atactcttgt taccttgtca 20 <210> 2198 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2198 tcgctcacat tccctgggaa 20 <210> 2199 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2199 gacttgtgcc cataaggagc 20 <210> 2200 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2200 gacaatgatt caaacatggc 20 <210> 2201 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2201 ggtcagtaaa tgctgggttt 20 <210> 2202 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2202 aggcgagctt tacactttta 20 <210> 2203 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2203 cggatggaca ccacttcctg 20 <210> 2204 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2204 tgtgccctcc accagcaggc 20 <210> 2205 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2205 cctgcaaatc accagagtcc 20 <210> 2206 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2206 cctagagaca tccccaccgc 20 <210> 2207 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2207 cagacgcacc atcacccaac 20 <210> 2208 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2208 cttcctggca cctctcatgt 20 <210> 2209 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2209 agcatcagaa tcaataacga 20 <210> 2210 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2210 cgagagcgca tcccagctcc 20 <210> 2211 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2211 agcaagttcc cacccaccct 20 <210> 2212 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2212 ctaagaaaac tcccttgcca 20 <210> 2213 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2213 ttccctctca tcctatagac 20 <210> 2214 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2214 gggcctttcc cacatggaaa 20 <210> 2215 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2215 ttgttgccca cccattccag 20 <210> 2216 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2216 taacccccac atcagagctc 20 <210> 2217 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2217 gaattgtgct tcacaagtca 20 <210> 2218 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2218 cctttgctgc ttctaacttc 20 <210> 2219 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2219 cagatcacc tctgtattcc 20 <210> 2220 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2220 tgctgtgtcc caccctgagc 20 <210> 2221 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2221 agcaggacca ctccctccac 20 <210> 2222 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2222 cgggatcatc ctctgccagc 20 <210> 2223 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2223 gaggccacca tcccagcagt 20 <210> 2224 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2224 agcacaggca tctactgacc 20 <210> 2225 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2225 gatgcattcc atccagatat 20 <210> 2226 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2226 gggatgtgaa accagaagcc 20 <210> 2227 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2227 actggagacc caccatctcc 20 <210> 2228 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2228 caggtcagca tcacagacct 20 <210> 2229 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2229 ctgagccccc acatgcacc 20 <210> 2230 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2230 ccaggagacc cagccggcgc 20 <210> 2231 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2231 agacccggca aaacactcct 20 <210> 2232 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2232 gtccgagcac cacagtgccc 20 <210> 2233 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2233 aagggcagca cctcggagtc 20 <210> 2234 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2234 tggatgcccc aatctgccca 20 <210> 2235 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2235 gatgatctac cccagaggac 20 <210> 2236 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2236 ccccgcagtca cctccccactg 20 <210> 2237 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2237 ctaaatggtc catcccagaa 20 <210> 2238 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2238 gtccctgtcc taatgagctg 20 <210> 2239 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2239 ccagcggtcc acctcctaat 20 <210> 2240 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2240 ctcctcgaac cttcacggcc 20 <210> 2241 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2241 cccgtaacaa atgaccgcaa 20 <210> 2242 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2242 catctttccc tcactcgcct 20 <210> 2243 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2243 ttcaagcctc gatcaagtaa 20 <210> 2244 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2244 ctgtggccgc ccacttctcc 20 <210> 2245 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2245 attgcacccc cagattccct 20 <210> 2246 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2246 gacgcagccc actcggataa 20 <210> 2247 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2247 cccggcttac aatcatgttt 20 <210> 2248 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2248 ggttcagctc cttgcgggat 20 <210> 2249 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2249 gcttgctgac ccaaacttca 20 <210> 2250 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2250 aggccctcca cttaatcata 20 <210> 2251 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2251 ggcagcagct ccattacctc 20 <210> 2252 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2252 gccacagtct ccacagcaga 20 <210> 2253 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2253 ccttcacggc ccctaaacca 20 <210> 2254 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2254 cgagggtctt ccatgagcgc 20 <210> 2255 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2255 ctcactcgcc tttttagagc 20 <210> 2256 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2256 ctagagacat ccccaccgca 20 <210> 2257 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2257 gttcagctcc ttgcgggatc 20 <210> 2258 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2258 tgaatccccc cacccttggc 20 <210> 2259 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2259 gctgcggacc acccacctct 20 <210> 2260 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2260 gaccgtgttt ctacataagc 20 <210> 2261 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2261 ccagtgcccc atcggtgcca 20 <210> 2262 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2262 ttcttagcat ttactgagac 20 <210> 2263 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2263 ccgcccactt ctccgagcac 20 <210> 2264 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2264 gctagtgcca ccgtgtcctc 20 <210> 2265 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2265 ggatgtgaaa ccagaagccc 20 <210> 2266 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2266 tgagccccca cattgcacct 20 <210> 2267 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2267 cccacatact tgtccagcca 20 <210> 2268 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2268 ggatgcccca atctgccccac 20 <210> 2269 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2269 atgaacaggt tccgcagcgg 20 <210> 2270 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2270 gccctccact taatcatatc 20 <210> 2271 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2271 ctgttgtgtt ggctgagggc 20 <210> 2272 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2272 cagcatatat tcaatcaact 20 <210> 2273 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2273 ctggagaccc accatctccc 20 <210> 2274 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2274 cgagctttac acttttagaa 20 <210> 2275 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2275 gttgaagccc ccaccgctga 20 <210> 2276 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2276 gaaaactccc ttgccaggca 20 <210> 2277 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2277 gccacgctgt ctaatcagct 20 <210> 2278 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2278 gtggctccaa cctgttctca 20 <210> 2279 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2279 aacccccaca tcagagctct 20 <210> 2280 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2280 taaatggtcc atcccagaag 20 <210> 2281 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2281 acacatggcc ccatacaggc 20 <210> 2282 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2282 gcaggaccac tccctccacc 20 <210> 2283 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2283 ctgcaaatca ccagagtccc 20 <210> 2284 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2284 ctttgctgct tctaacttcc 20 <210> 2285 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2285 ccccttttta caaatcttca 20 <210> 2286 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2286 cagcggtcca cctcctaata 20 <210> 2287 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2287 tccctctcat cctatagaca 20 <210> 2288 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2288 gctgacccaa acttcaagcc 20 <210> 2289 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2289 gcattccatc cagatatggc 20 <210> 2290 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2290 ctggattcct gttccaggac 20 <210> 2291 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2291 cggcaaaaca ctcctggatt 20 <210> 2292 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2292 atggacacca cttcctgccc 20 <210> 2293 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2293 gctgtgtccc accctgagct 20 <210> 2294 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2294 gggacctctc tcttttaatc 20 <210> 2295 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2295 ttcctggcac ctctcatgtc 20 <210> 2296 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2296 gagagactcc tctcacacac 20 <210> 2297 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2297 aggagcagtc tcagctgcca 20 <210> 2298 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2298 ggcaacacag gcaaaccgac 20 <210> 2299 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2299 cagcagacac tcaacttgac 20 <210> 2300 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2300 cgctcacatt ccctgggaac 20 <210> 2301 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2301 gggtttagaa aatgaggctt 20 <210> 2302 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2302 ctgcccgtat tcttcctgaa 20 <210> 2303 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2303 gcagcagctc cattacctct 20 <210> 2304 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2304 aaggcaacag caacagtgcc 20 <210> 2305 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2305 taagctctgt ccagcaggcc 20 <210> 2306 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2306 gttgcccacc cattccagca 20 <210> 2307 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2307 atcactctgc ttcaagggct 20 <210> 2308 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2308 gcacaggcat ctactgaccc 20 <210> 2309 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2309 tctgtattcc acacacattt 20 <210> 2310 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2310 ccctccgacc tttactccag 20 <210> 2311 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2311 ctggccactc ctcctaggcg 20 <210> 2312 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2312 cccgcaggca tcctgggcct 20 <210> 2313 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2313 caccagccta acccctgttc 20 <210> 2314 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2314 ctgtcccgcc ctccatggca 20 <210> 2315 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2315 agacgcacca tcacccaaca 20 <210> 2316 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2316 gtcactctgt caatttgtct 20 <210> 2317 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2317 cgtgaagtcc ctccccgggac 20 <210> 2318 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2318 tgctgtggtt acaaatgacc 20 <210> 2319 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2319 gcaagttccc acccaccctc 20 <210> 2320 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2320 ccgcagtcac ctccccactgc 20 <210> 2321 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2321 atgatctacc ccagaggacc 20 <210> 2322 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2322 gaccgcaaac ttagcagcta 20 <210> 2323 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2323 gagggcagct cccttcgcct 20 <210> 2324 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2324 aggtcagcat cacagacctc 20 <210> 2325 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2325 cggcggcaca cactatagcc 20 <210> 2326 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2326 tcagaatcaa taacgatctg 20 <210> 2327 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2327 cttccaggca ctcgcaggcc 20 <210> 2328 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2328 gtccattctc atccactcat 20 <210> 2329 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2329 ggataatcgc cctttgatta 20 <210> 2330 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2330 ccgtgtttct acataagcca 20 <210> 2331 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2331 acttagcagc taaaacgaca 20 <210> 2332 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2332 ggacaccact tcctgcccaa 20 <210> 2333 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2333 tagagacatc cccaccgcaa 20 <210> 2334 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2334 acccccacat cagagctcta 20 <210> 2335 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2335 caggtgcctc taacatagac 20 <210> 2336 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2336 ggcctgggac ccatctggac 20 <210> 2337 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2337 agcatatatt caatcaactt 20 <210> 2338 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2338 gtcagcatca cagacctcct 20 <210> 2339 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2339 aaatggtcca tcccagaagg 20 <210> 2340 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2340 cctcagtgct tactgagcac 20 <210> 2341 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2341 ttcctgttcc aggactccaa 20 <210> 2342 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2342 gaggctttgc tttaaaaggt 20 <210> 2343 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2343 ccacgctgtc taatcagctc 20 <210> 2344 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2344 ggacctctct cttttaatcc 20 <210> 2345 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2345 actcgccttt ttagagccct 20 <210> 2346 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2346 gtggagtgtc cctctgcacc 20 <210> 2347 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2347 cagatccaaa acagaggcca 20 <210> 2348 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2348 ggcattgtgg caaacaggtc 20 <210> 2349 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2349 cctgcagacc caacttccac 20 <210> 2350 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2350 cccacccacc ctcatcgcgg 20 <210> 2351 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2351 tcactctgct tcaagggctt 20 <210> 2352 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2352 agagactcct ctcacacacc 20 <210> 2353 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2353 tgacccaaac ttcaagccac 20 <210> 2354 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2354 cttcacggcc cctaaaccac 20 <210> 2355 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2355 ttaaaaggaa ctctaccttc 20 <210> 2356 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2356 agcagacact caacttgacc 20 <210> 2357 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2357 cacatggccc catacaggca 20 <210> 2358 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2358 gcaaatcacc agagtcccca 20 <210> 2359 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2359 atctactgac ccctctggaa 20 <210> 2360 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2360 agcggtccac ctcctaatac 20 <210> 2361 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2361 cgcagtcacc tcccactgcc 20 <210> 2362 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2362 tgcacagatc ttcatagcaa 20 <210> 2363 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2363 ggtctgctca cctcacttgc 20 <210> 2364 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2364 ggaccaaccc cagatggtcc 20 <210> 2365 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2365 agcagctcca ttacctctgc 20 <210> 2366 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2366 ttttacaaat cttcatggtc 20 <210> 2367 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2367 gggagatgtc tctccaagct 20 <210> 2368 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2368 ggcctcagca ccagatgcct 20 <210> 2369 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2369 tggccactcc tcctaggcgg 20 <210> 2370 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2370 gggtccgtca cacccagcag 20 <210> 2371 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2371 cctctcatcc tatagacacc 20 <210> 2372 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2372 tcctggcacc tctcatgtcc 20 <210> 2373 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2373 gctttacact tttagaagaa 20 <210> 2374 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2374 gccaccgtgt cctcacacgc 20 <210> 2375 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2375 tgggaacgaa cccacagccc 20 <210> 2376 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2376 cctgggttcc acacctgacc 20 <210> 2377 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2377 gcgctgctcc acctgcccaa 20 <210> 2378 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2378 gcccacttct ccgagcacca 20 <210> 2379 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2379 atgacatgca tttcactcac 20 <210> 2380 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2380 gctactgcaa tgaccggcca 20 <210> 2381 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2381 taattcaaat tcaactgctc 20 <210> 2382 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2382 ggaaaggtct tcacaggcca 20 <210> 2383 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2383 ccattctcat ccactcatca 20 <210> 2384 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2384 accagcctaa cccctgttcc 20 <210> 2385 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2385 gcccgtattc ttcctgaaga 20 <210> 2386 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2386 ccctccactt aatcatatct 20 <210> 2387 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2387 gccatgccag actcacccaa 20 <210> 2388 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2388 gcccagttct ccttctcaaa 20 <210> 2389 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2389 tcatgctcag aaaatgacca 20 <210> 2390 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2390 cattccatcc agatatggct 20 <210> 2391 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2391 cgcaccatca cccaacagca 20 <210> 2392 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2392 atcctgggcc tctccagact 20 <210> 2393 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2393 tggttgggtc tccctgcccc 20 <210> 2394 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2394 gctgttgtcc ccagcaggcc 20 <210> 2395 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2395 tgctgcttct aacttccaga 20 <210> 2396 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2396 gggagcccat ttcccaagtt 20 <210> 2397 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2397 ttgccaggca cccataggtc 20 <210> 2398 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2398 agagcagcaa catggagccc 20 <210> 2399 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2399 tggagaccca ccatctcccc 20 <210> 2400 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2400 gaccacaaat tcaattgcta 20 <210> 2401 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2401 gaatcccccc acccttggct 20 <210> 2402 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2402 cctccgacct ttactccagg 20 <210> 2403 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2403 ggcggcacac actatagcct 20 <210> 2404 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2404 gagatgctct caccaggagc 20 <210> 2405 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2405 gcacttccac cttacccaga 20 <210> 2406 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2406 ccaacttcca ctttgcaaaa 20 <210> 2407 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2407 aaaatgacca actcactggc 20 <210> 2408 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2408 acaagagaac atctgtgccg 20 <210> 2409 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2409 agcccagtca cccgtgagca 20 <210> 2410 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2410 catcactgtc ccaatcaccc 20 <210> 2411 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2411 acacgcccag gcaaaccgcc 20 <210> 2412 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2412 cactaggcct ccatgcaccc 20 <210> 2413 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2413 cgacctttac tccaggcctc 20 <210> 2414 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2414 cagacgcatc catttcctcc 20 <210> 2415 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2415 tgggacccag tcatgaacta 20 <210> 2416 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2416 gggttctgcc ctcttctgac 20 <210> 2417 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2417 cccacacgca acaaaggcac 20 <210> 2418 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2418 ccataggtca aaaagggccc 20 <210> 2419 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2419 agcgaggcca cccatgtgaa 20 <210> 2420 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2420 atcttcatag caacccatgc 20 <210> 2421 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2421 cacaagtgtt ttaagcacac 20 <210> 2422 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2422 tgcactgaac cacctggtgc 20 <210> 2423 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2423 ggtccacccc agacgatcca 20 <210> 2424 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2424 caggaggccc ttcaagctcc 20 <210> 2425 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2425 tgtggtcccc ctcgccacgc 20 <210> 2426 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2426 gcagctgact ctcccgcccc 20 <210> 2427 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2427 ctggagtact ctccacagac 20 <210> 2428 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2428 ccacttgctc cactgtgcga 20 <210> 2429 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2429 gaggcataaa cacacttaca 20 <210> 2430 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2430 tcctgtgtcc acacctgcgg 20 <210> 2431 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2431 ctcacgggac tccatcatta 20 <210> 2432 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2432 agactcaccc aaccctacca 20 <210> 2433 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2433 gccggacacc aggcctgcaa 20 <210> 2434 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2434 tttggacacc atccggggcc 20 <210> 2435 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2435 ccaccgcaac cccttctgct 20 <210> 2436 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2436 tctccaccca cagaatagga 20 <210> 2437 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2437 gccctgcccc agacgcaccg 20 <210> 2438 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2438 acatcgccat tcccagagtc 20 <210> 2439 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2439 ccacagatta taacccacag 20 <210> 2440 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2440 ccccagcaca tcctggcctt 20 <210> 2441 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2441 gaccagaccc cagaatctcc 20 <210> 2442 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2442 tgaaaacgat ccattttccc 20 <210> 2443 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2443 ccatggtgct tcctagggca 20 <210> 2444 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2444 aggcggtaca tccacgggct 20 <210> 2445 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2445 atggatacag tccctaggac 20 <210> 2446 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2446 tctgaagatt cctccccgca 20 <210> 2447 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2447 ccatcgcccc acactccact 20 <210> 2448 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2448 gtggctctcc cttgcagaat 20 <210> 2449 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2449 cgtgtcctca cacgctcctc 20 <210> 2450 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2450 cgggaaagcc acacacaact 20 <210> 2451 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2451 gctgtgagcc tcacctcccc 20 <210> 2452 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2452 ggtacatccc acatctgcgg 20 <210> 2453 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2453 cctgatgccc tccccccgagc 20 <210> 2454 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2454 tccccccgaca tacacagcat 20 <210> 2455 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2455 gcacacaacc catgtgccca 20 <210> 2456 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2456 catctcccga tatagcccta 20 <210> 2457 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2457 ctgtccggag aatccaggcc 20 <210> 2458 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2458 cctaaaccac cactgcccct 20 <210> 2459 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2459 cggagagtcc tcccagccct 20 <210> 2460 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2460 ctgccttgcc acacaaaaca 20 <210> 2461 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2461 tcgacacaca acatacacaa 20 <210> 2462 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2462 cccagacccc tcaccaaaca 20 <210> 2463 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2463 accagacacc agcccaagca 20 <210> 2464 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2464 gctgccgttt tcaagaatta 20 <210> 2465 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2465 ccagagtgca gaacagcagc 20 <210> 2466 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2466 gaatcctcac ccttagccct 20 <210> 2467 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2467 ccaagagacc ccacctggcc 20 <210> 2468 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2468 aaccagtgag tcactacgaa 20 <210> 2469 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2469 aacaagggct ctcacacctc 20 <210> 2470 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2470 gcctcctgaa atctgggctt 20 <210> 2471 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2471 tgtcacccca ccagcagcat 20 <210> 2472 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2472 caggtgcctt cctttgccgt 20 <210> 2473 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2473 tccgtggacc ttctgggtcc 20 <210> 2474 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2474 tcagcgaact taattatatc 20 <210> 2475 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2475 gttgacccca ccccagaggc 20 <210> 2476 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2476 ctctcatcct atagacacca 20 <210> 2477 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2477 aggtaagtgt aaaatggtcc 20 <210> 2478 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2478 gtgttgatca tctccaggac 20 <210> 2479 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2479 ctaatcagct cccaatccct 20 <210> 2480 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2480 ggagctgcca gcaatagcaa 20 <210> 2481 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2481 cagatggtcc accctggaca 20 <210> 2482 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2482 ccttgcaaat atcccaggtt 20 <210> 2483 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2483 gtagagtccc agcacctgcc 20 <210> 2484 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2484 agtcttgaaa ccatggtcct 20 <210> 2485 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2485 caccagcgca cacctgccac 20 <210> 2486 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2486 tgcacagctc ccatggatga 20 <210> 2487 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2487 ggcccaagca cttcacaccc 20 <210> 2488 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2488 gggcctggtt tccctattta 20 <210> 2489 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2489 gtccacggca ccctctcctc 20 <210> 2490 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2490 ggcctcagcc ttcactcaca 20 <210> 2491 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2491 ccactcctga ctcttggttc 20 <210> 2492 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2492 ccctgatgaa acttcagccc 20 <210> 2493 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2493 gtgcctcccc ccacggcagc 20 <210> 2494 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2494 caaggcagca ctcactctac 20 <210> 2495 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2495 ccattttaac cctctttgcc 20 <210> 2496 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2496 atctgaagcc ccaaactagc 20 <210> 2497 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2497 aggtgccgaa ccttaaggac 20 <210> 2498 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2498 acactatgcc actaaggaca 20 <210> 2499 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2499 ggctcgctgt caacacacga 20 <210> 2500 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2500 ccaagggacc cactgaggct 20 <210> 2501 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2501 tcttggctca cccagatcat 20 <210> 2502 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2502 ccctggatgc tcaacagccg 20 <210> 2503 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2503 cggaacacac tttcactctc 20 <210> 2504 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2504 tcacagcccc agccttcgcc 20 <210> 2505 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2505 cccttactca tcagtggccg 20 <210> 2506 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2506 tcccagacac actcagggcc 20 <210> 2507 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2507 cacgcagaaa ctctgggctc 20 <210> 2508 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2508 caggaataca gcattacaat 20 <210> 2509 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2509 caggtaagca tttaaacctt 20 <210> 2510 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2510 actggagaca ccatcttcgg 20 <210> 2511 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2511 gagagactcc acctgtccaa 20 <210> 2512 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2512 aagttgccca ctcctgtact 20 <210> 2513 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2513 gaattattcc catgggctca 20 <210> 2514 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2514 ctgcggaatc ccctcctgca 20 <210> 2515 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2515 cactggcttc cggacagcca 20 <210> 2516 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2516 tccagaagaa caaacctacc 20 <210> 2517 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2517 tgggcccgca catctcacat 20 <210> 2518 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2518 ggatgatcca ccccagacgg 20 <210> 2519 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2519 gtgctcagcc ctttgcttca 20 <210> 2520 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2520 ctgctcaaac catcaggacc 20 <210> 2521 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2521 tcttggtttc caatcatcat 20 <210> 2522 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2522 ctgcacatcc cgatttggcc 20 <210> 2523 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2523 ctgtccactt cctccaccgg 20 <210> 2524 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2524 accacgctag acctcaggct 20 <210> 2525 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2525 acagtgcccc ctcagtgggc 20 <210> 2526 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2526 ggacacagtt caatccccgaa 20 <210> 2527 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2527 gtggaccttc catcgctcct 20 <210> 2528 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2528 cagaattctc cattcctgat 20 <210> 2529 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2529 tctccctcca atagaacctc 20 <210> 2530 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2530 ttatgactca atgagcccaa 20 <210> 2531 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2531 ggagactcat cccaccccac 20 <210> 2532 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2532 aggagctaat gaaacagcct 20 <210> 2533 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2533 caccaccaag aaacatcgca 20 <210> 2534 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2534 ctagacaatc caccctggat 20 <210> 2535 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2535 tcagggtcat cctcgaagcc 20 <210> 2536 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2536 gaggaaaact ccaatgctgc 20 <210> 2537 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2537 aaggagacct cactgctcac 20 <210> 2538 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2538 gtacaaacca gtaaggaacc 20 <210> 2539 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2539 ccgccatgcc tccctgacat 20 <210> 2540 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2540 ggattcgccc tctcagggtc 20 <210> 2541 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2541 tggcaggtcc accctccccc 20 <210> 2542 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2542 gccacccttc ccaaactcag 20 <210> 2543 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2543 gtgcatcacc aggcgagccc 20 <210> 2544 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2544 tgggatggct tctaatggca 20 <210> 2545 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2545 acccctctca catgcccggc 20 <210> 2546 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2546 tgtttgtgcc caccacctct 20 <210> 2547 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2547 tgagctggcc ctccccccgc 20 <210> 2548 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2548 cgggaagctc cacaccagct 20 <210> 2549 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2549 actgctgcca ttcacatgac 20 <210> 2550 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2550 ggctggccca actctagctg 20 <210> 2551 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2551 gtgagctcca cctcatgccg 20 <210> 2552 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2552 gatggaagcc cccttcaacc 20 <210> 2553 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2553 cagctcattt cactccggca 20 <210> 2554 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2554 ggcatgggac aatctccccc 20 <210> 2555 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2555 acacaggtcc ataccccacc 20 <210> 2556 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2556 aggtcgggct atctaaccca 20 <210> 2557 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2557 caggctactc cccccaggcc 20 <210> 2558 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2558 ccacgccatc tcctgagttc 20 <210> 2559 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2559 gccagactca cccaacccta 20 <210> 2560 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2560 gggttgtgga cctctaggta 20 <210> 2561 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2561 cctttgctcc cctgtgggcc 20 <210> 2562 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2562 gcggccctca ctctccggcc 20 <210> 2563 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2563 cccctcccca cctactgcgg 20 <210> 2564 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2564 gtgaaagacc ctctctggtc 20 <210> 2565 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2565 cccgttctcc caccttgact 20 <210> 2566 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2566 ctgcatctcc cgatatagcc 20 <210> 2567 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2567 accatcggca cacaacccat 20 <210> 2568 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2568 ccgtattctt cctgaagact 20 <210> 2569 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2569 gcttgggaca gcaaacagcc 20 <210> 2570 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2570 atccctgtcc acaggggtc 20 <210> 2571 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2571 tcacacccag cagacagccg 20 <210> 2572 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2572 agtcacctcc cactgcctgc 20 <210> 2573 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2573 ctgacagctt ctcctggcca 20 <210> 2574 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2574 tatattcaat caacttagga 20 <210> 2575 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2575 cccgagctaa cacccgtcct 20 <210> 2576 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2576 gaccccagca catcctggcc 20 <210> 2577 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2577 tgctccagcc tttccgtgga 20 <210> 2578 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2578 cacagatctt catagcaacc 20 <210> 2579 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2579 acctgtctcc tctctcccgt 20 <210> 2580 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2580 gagcaccacc acaaaaagga 20 <210> 2581 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2581 gcggcacttc caccttaccc 20 <210> 2582 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2582 cttcctgccc aatatcggaa 20 <210> 2583 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2583 tgcatgtcac cccaccagca 20 <210> 2584 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2584 cccccacctt taccctggct 20 <210> 2585 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2585 gtgtttctac ataagccaca 20 <210> 2586 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2586 gtttatctgg caaacagcaa 20 <210> 2587 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2587 tttctgacct cactaggcct 20 <210> 2588 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2588 aggctcagtc tttccagtca 20 <210> 2589 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2589 actggagccc tcccagaccc 20 <210> 2590 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2590 cccctaaacc accactgccc 20 <210> 2591 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2591 gacccaactt ccactttgca 20 <210> 2592 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2592 cttccctctc atcctataga 20 <210> 2593 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2593 gtgcctctaa catagacact 20 <210> 2594 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2594 gcatttcact cactcaggac 20 <210> 2595 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2595 acaggttccg cagcggcggc 20 <210> 2596 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2596 gagcccattt cccaagttca 20 <210> 2597 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2597 ctcaaactct cctagtgggt 20 <210> 2598 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2598 cagcaggcca ccaccccgtc 20 <210> 2599 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2599 aaagcatgca tccccccgaca 20 <210> 2600 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2600 gaccatcgcc ccacactcca 20 <210> 2601 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2601 gagacatccc caccgcaacc 20 <210> 2602 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2602 ttggagttcc cacagtgtga 20 <210> 2603 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2603 acgctgtcta atcagctccc 20 <210> 2604 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2604 caccgtgtcc tcacacgctc 20 <210> 2605 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2605 cagctccatt acctctgctc 20 <210> 2606 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2606 atggtccacc ttgaatggtc 20 <210> 2607 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2607 ctgctaatcc ccctcaccac 20 <210> 2608 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2608 cccaaccatc cccagaggac 20 <210> 2609 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2609 gctcagcgaa cttaattata 20 <210> 2610 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2610 tcacaggcca cctgttcccc 20 <210> 2611 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2611 gggagcctca ccatgccctt 20 <210> 2612 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2612 caccatcacc caacagcatg 20 <210> 2613 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2613 cttcatggtc ctcatggata 20 <210> 2614 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2614 cggctgctcc atgatgcagt 20 <210> 2615 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2615 cagaaaatga ccaactcact 20 <210> 2616 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2616 gattggtgaa tcaaagccaa 20 <210> 2617 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2617 tggctgagcc ctcccgtccc 20 <210> 2618 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2618 tgcagacgca tccatttcct 20 <210> 2619 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2619 gatatggctc ctactccacc 20 <210> 2620 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2620 gccacgcccc tcgccgacca 20 <210> 2621 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2621 gaaatggaca cacccggaca 20 <210> 2622 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2622 gaggctccac tgccttgcca 20 <210> 2623 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2623 ggctttgctt taaaaggtaa 20 <210> 2624 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2624 tgtcactgtc caccagggca 20 <210> 2625 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2625 aatggtccac cccagacgat 20 <210> 2626 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2626 gcaccccaca accccaagtc 20 <210> 2627 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2627 agacccacca tctccccaga 20 <210> 2628 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2628 caattgctaa accacacttt 20 <210> 2629 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2629 ggccacagat tataacccac 20 <210> 2630 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2630 gtagggcact cacctggatc 20 <210> 2631 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2631 agtgccggaa tcctcaccct 20 <210> 2632 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2632 ggtgcttttc catagcagct 20 <210> 2633 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2633 gccaggcacc cataggtcaa 20 <210> 2634 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2634 cagaaagcca attccagctc 20 <210> 2635 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2635 ctggcatcca ccggctcccc 20 <210> 2636 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2636 ctggtgcctt ctacaggctc 20 <210> 2637 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2637 cagggcagaa ttaccttgca 20 <210> 2638 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2638 cgtcctccca cctcacacgg 20 <210> 2639 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2639 ctgccagccc cctcagcgga 20 <210> 2640 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2640 ctgagcactc ttacgcataa 20 <210> 2641 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2641 gtcccatctc cacacagggc 20 <210> 2642 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2642 ggacctcaac cccctacttg 20 <210> 2643 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2643 ggtctttctc ctccccaccac 20 <210> 2644 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2644 caccccccaa ttcctacctc 20 <210> 2645 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2645 gtcttagcca ccaaggcctt 20 <210> 2646 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2646 cagctgtacc cacaggcggc 20 <210> 2647 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2647 cagaggctcc ctaggagcac 20 <210> 2648 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2648 ctataatgct ctcatggctc 20 <210> 2649 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2649 gatccacact ccagaagaac 20 <210> 2650 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2650 tccaaactca caggctactc 20 <210> 2651 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2651 acaggccatt cccactcgct 20 <210> 2652 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2652 cttaattacc tctaaagaac 20 <210> 2653 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2653 acgacaggca acagcagcct 20 <210> 2654 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2654 accgtggcca cctgcatgac 20 <210> 2655 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2655 gcaggtagtc atacacagat 20 <210> 2656 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2656 tgggctcatt attagagcac 20 <210> 2657 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2657 gacagattca aaaacaggcc 20 <210> 2658 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2658 gcaggcctcc ccattgtcca 20 <210> 2659 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2659 agctctatct tcccagacac 20 <210> 2660 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2660 ctggacattc tcaaagtgcc 20 <210> 2661 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2661 ccagaggacc cacctgcagt 20 <210> 2662 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2662 tccaggatcc ctatgggctc 20 <210> 2663 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2663 cagtgcctca cacgcggtca 20 <210> 2664 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2664 gcccaaaact acagcggtct 20 <210> 2665 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2665 tggccttgtc ttacttctta 20 <210> 2666 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2666 gcccatccac ccacttggac 20 <210> 2667 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2667 caggtgcttg accttagcct 20 <210> 2668 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2668 tgctcaactc cagagaacca 20 <210> 2669 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2669 cagcatccaa acccacggtg 20 <210> 2670 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2670 gaagctctaa tccctggcca 20 <210> 2671 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2671 tcagtgacac tcaaaagtgc 20 <210> 2672 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2672 gcgactctga acctctgcct 20 <210> 2673 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2673 cagctggaac tcctgacacc 20 <210> 2674 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2674 tgcaaccctg cccattgcca 20 <210> 2675 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2675 agggaacccc accacatcac 20 <210> 2676 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2676 cgcacccctc tcacatgccc 20 <210> 2677 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2677 gctgggcccg catctggagc 20 <210> 2678 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2678 ccaagatac cctcaggatc 20 <210> 2679 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2679 cccttaacca cctgtgcatc 20 <210> 2680 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2680 tgacgggacc atactcagga 20 <210> 2681 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2681 gcgcagccca gccctagctt 20 <210> 2682 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2682 ggtccacccc agacagtcca 20 <210> 2683 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2683 acgggtcccc atcttgccta 20 <210> 2684 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2684 cgcctgaatc ccccacgcca 20 <210> 2685 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2685 ccaaagctca caacactcag 20 <210> 2686 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2686 tctgttttac actaatgcgg 20 <210> 2687 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2687 tggatggtcc cccctggaca 20 <210> 2688 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2688 ccaaagtctc ccccctaccc 20 <210> 2689 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2689 gctggcccca catgcaggca 20 <210> 2690 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2690 aaaactctcc tcactagcct 20 <210> 2691 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2691 cccacacgcc atacagttat 20 <210> 2692 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2692 caagtcctca cctgcaatcc 20 <210> 2693 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2693 ccaacaggtt ctacctacca 20 <210> 2694 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2694 aagcccccaa ctcacttgcc 20 <210> 2695 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2695 cacccgtcac cctctgcacc 20 <210> 2696 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2696 ccctgctcag cacgaagcca 20 <210> 2697 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2697 tgagctccca actctgtcca 20 <210> 2698 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2698 gcataacaca aatattgcca 20 <210> 2699 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2699 gtccttggca ttcactgagc 20 <210> 2700 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2700 aggctgggca ttatccctca 20 <210> 2701 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2701 gactgggatc ccacctggcc 20 <210> 2702 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2702 tcccaggctt ctcttgggac 20 <210> 2703 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2703 ccgggttcgc ccttactcat 20 <210> 2704 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2704 ctgcaattca acactgcctt 20 <210> 2705 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2705 cccagaccat catcgatgcc 20 <210> 2706 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2706 ctgctgtcca ctcctgaaca 20 <210> 2707 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2707 aagctgctaa aagaaatgcc 20 <210> 2708 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2708 gcatgtcgcc ctggctgcct 20 <210> 2709 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2709 gatctgattg gaaataggtc 20 <210> 2710 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2710 caccagctca tttcactccg 20 <210> 2711 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2711 gtggagactc atcccacccc 20 <210> 2712 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2712 atgaattatt cccatgggct 20 <210> 2713 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2713 gcctcttctg caaatgggac 20 <210> 2714 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2714 gaactggacc acgctagacc 20 <210> 2715 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2715 atataaccac cccctacccc 20 <210> 2716 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2716 gccattccca ctcgctgtgc 20 <210> 2717 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2717 agctcacaac actcagggta 20 <210> 2718 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2718 tcatagggcc tgcctagcct 20 <210> 2719 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2719 gccattttaa ccctctttgc 20 <210> 2720 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2720 gaagctgcaa ttcagagcat 20 <210> 2721 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2721 ttgccaggac ctcactggct 20 <210> 2722 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2722 ccagctcatt tcactccggc 20 <210> 2723 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2723 cgctcactcc ctgattctga 20 <210> 2724 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2724 ctggatgatc caccccagac 20 <210> 2725 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2725 cacccctctc acatgcccgg 20 <210> 2726 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2726 tagtgcctcc ccccacggca 20 <210> 2727 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2727 ggtgagctgg ccctcccccc 20 <210> 2728 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2728 gcctgctgca catcccgatt 20 <210> 2729 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2729 tttgggataa taataggtcc 20 <210> 2730 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2730 cccacgggac cctcactgcc 20 <210> 2731 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2731 ctgccagccc taacttagct 20 <210> 2732 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2732 cccctactct ctgctggtca 20 <210> 2733 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2733 tggctcccac cccatggact 20 <210> 2734 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2734 ctggctggcc caactctagc 20 <210> 2735 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2735 ccctaggtcc tgcccaggcc 20 <210> 2736 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2736 gagtcttgaa accatggtcc 20 <210> 2737 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2737 ctatcttccc agacacactc 20 <210> 2738 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2738 ggccggaaca cactttcact 20 <210> 2739 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2739 ctggttccac catcaagagc 20 <210> 2740 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2740 gagtcccacc accaagaaac 20 <210> 2741 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2741 catgaatgtc cctaagagca 20 <210> 2742 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2742 agttatgact caatgagccc 20 <210> 2743 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2743 ccactctccc tccaatagaa 20 <210> 2744 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2744 ccacagggct ctgcccgccc 20 <210> 2745 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2745 gaggcttaag tctcaggtca 20 <210> 2746 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2746 ttggcaggtc caccctcccc 20 <210> 2747 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2747 ttgtgtcaca cacatgagtc 20 <210> 2748 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2748 gtcttggttt ccaatcatca 20 <210> 2749 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2749 ttcagggtca tcctcgaagc 20 <210> 2750 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2750 tcggtggacc ttccatcgct 20 <210> 2751 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2751 cacagatccc acctgtgtgt 20 <210> 2752 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2752 ggcggatccc agcctctgca 20 <210> 2753 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2753 acccgtctgc tcaaaccatc 20 <210> 2754 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2754 tgctcactga ccctgagtca 20 <210> 2755 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2755 catctcccca atagcagggt 20 <210> 2756 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2756 ccagggttta atgatcccct 20 <210> 2757 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2757 gaggagctaa tgaaacagcc 20 <210> 2758 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2758 cactcctgaa cactcaggaa 20 <210> 2759 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2759 gatcttggct cacccagatc 20 <210> 2760 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2760 accttgcaaa tatcccaggt 20 <210> 2761 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2761 caaggagacc tcactgctca 20 <210> 2762 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2762 aggttctacc taccaaggga 20 <210> 2763 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2763 cgtacaaacc agtaaggaac 20 <210> 2764 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2764 tctgtccact tcctccaccg 20 <210> 2765 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2765 tcattcccgc catctgcgga 20 <210> 2766 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2766 gacacaggtc cataccccac 20 <210> 2767 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2767 agagagactc cacctgtcca 20 <210> 2768 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2768 ccgggaagct ccacaccagc 20 <210> 2769 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2769 agggtcagac cctctgagcc 20 <210> 2770 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2770 gaggtttcta cagccaccgt 20 <210> 2771 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2771 ctacgggtat gaaaaagtca 20 <210> 2772 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2772 gctttgatat ataaatcttg 20 <210> 2773 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2773 gtcacgggac agctcaccca 20 <210> 2774 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2774 caacactgcc ttactgtgaa 20 <210> 2775 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2775 gcagaattct ccattcctga 20 <210> 2776 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2776 aggcagacga cccctggtct 20 <210> 2777 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2777 aaagttgccc actcctgtac 20 <210> 2778 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2778 tctgagaccc atctgggtct 20 <210> 2779 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2779 cctagacaat ccaccctgga 20 <210> 2780 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2780 cgttagagaa ttacacaaaa 20 <210> 2781 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2781 acaccagcgc acacctgcca 20 <210> 2782 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2782 acaggctact ccccccaggc 20 <210> 2783 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2783 gcccttactc atcagtggcc 20 <210> 2784 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2784 ggtgagctcc acctcatgcc 20 <210> 2785 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2785 cacgagtacc ctctgccagc 20 <210> 2786 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2786 cactccagaa gaacaaacct 20 <210> 2787 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2787 aaccccacca catcactggc 20 <210> 2788 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2788 accagagtcc ccaccggagc 20 <210> 2789 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2789 ggagtgtccc tctgcacccc 20 <210> 2790 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2790 aacaggttcc gcagcggcgg 20 <210> 2791 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2791 gcagtcacct cccactgcct 20 <210> 2792 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2792 gcagctccat tacctctgct 20 <210> 2793 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2793 cgtgtttcta cataagccac 20 <210> 2794 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2794 caagcggcac ttccacctta 20 <210> 2795 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2795 ccacccaccc tcatcgcggc 20 <210> 2796 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2796 catgtcctgc ttaatgcctg 20 <210> 2797 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2797 tgcatttcac tcactcagga 20 <210> 2798 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2798 ggagacccac catctcccca 20 <210> 2799 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2799 cttctgagtc caaactggga 20 <210> 2800 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2800 cagacactca acttgacctc 20 <210> 2801 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2801 gccctgacca tcgccccaca 20 <210> 2802 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2802 ggctcagctt ccctctcgct 20 <210> 2803 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2803 aggtgcctct aacatagaca 20 <210> 2804 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2804 ttagcagcta aaacgacacc 20 <210> 2805 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2805 gcacagatct tcatagcaac 20 <210> 2806 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2806 attccatcca gatatggctc 20 <210> 2807 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2807 gcggtccacc tcctaatacc 20 <210> 2808 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2808 ttactgagca ccactgcagt 20 <210> 2809 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2809 aacgaaccca cagcccaccg 20 <210> 2810 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2810 cacgctgtct aatcagctcc 20 <210> 2811 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2811 attcaattgc taaaccacac 20 <210> 2812 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2812 ctcatttgtt tatctggcaa 20 <210> 2813 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2813 tctactgacc cctctggaac 20 <210> 2814 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2814 ggagcccatt tcccaagttc 20 <210> 2815 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2815 ccaggtttat gatcgaggga 20 <210> 2816 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2816 aaggtcttca caggccacct 20 <210> 2817 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2817 ccttccctct catcctatag 20 <210> 2818 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2818 tctgctaatc cccctcacca 20 <210> 2819 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2819 tttacaaatc ttcatggtcc 20 <210> 2820 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2820 aggctttgct ttaaaaggta 20 <210> 2821 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2821 tgcgggatct gtagtaggcc 20 <210> 2822 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2822 agactctgcc actcctgcac 20 <210> 2823 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2823 tgcagaccca acttccactt 20 <210> 2824 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2824 tgacgaggct ccactgcctt 20 <210> 2825 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2825 gcaccatcac ccaacagcat 20 <210> 2826 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2826 cggccacaga ttataaccca 20 <210> 2827 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2827 gaatggtcca ccccagacga 20 <210> 2828 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2828 atgcatgtca ccccaccagc 20 <210> 2829 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2829 ttcaactgct cagcgaactt 20 <210> 2830 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2830 agagacatcc ccaccgcaac 20 <210> 2831 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2831 acatggcccc atacaggcac 20 <210> 2832 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2832 gcccctaaac caccactgcc 20 <210> 2833 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2833 aaacaggtcc ctcccgagct 20 <210> 2834 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2834 cacttcctgc ccaatatcgg 20 <210> 2835 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2835 gcggcacaca ctatagcctc 20 <210> 2836 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2836 gctgacagct tctcctggcc 20 <210> 2837 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2837 aggatggtca tccttcggct 20 <210> 2838 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2838 ggtggtgccc ttcatggagc 20 <210> 2839 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2839 gtctgctcac ctcacttgct 20 <210> 2840 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2840 tctccgagca ccaccacaaa 20 <210> 2841 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2841 cagagctcta acacctggga 20 <210> 2842 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2842 gctgcttcta acttccagaa 20 <210> 2843 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2843 ttgtcactgt ccaccagggc 20 <210> 2844 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2844 tccgtcacac ccagcagaca 20 <210> 2845 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2845 atgccagact cacccaaccc 20 <210> 2846 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2846 gcccaaccat ccccagagga 20 <210> 2847 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2847 gctggaggcc ctcgcagctc 20 <210> 2848 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2848 gctcagaaaa tgaccaactc 20 <210> 2849 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2849 cccgtattct tcctgaagac 20 <210> 2850 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2850 ctgttgtccc cagcaggcca 20 <210> 2851 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2851 gaactctacc ttcagcccgt 20 <210> 2852 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2852 tctgcccgtc ctctcccctt 20 <210> 2853 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2853 gatgctctca ccaggagcct 20 <210> 2854 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2854 gctgcggccc tcactctccg 20 <210> 2855 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2855 ctccgacctt tactccaggc 20 <210> 2856 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2856 gacccaaact tcaagccacc 20 <210> 2857 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2857 cagttctcct tctcaaactc 20 <210> 2858 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2858 ctgggaccca tctggacccc 20 <210> 2859 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2859 tgccaggcac ccataggtca 20 <210> 2860 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2860 ctagatggtc caccttgaat 20 <210> 2861 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2861 tcaagggctt ttactggtgc 20 <210> 2862 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2862 gcatatattc aatcaactta 20 <210> 2863 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2863 gtttctgacc tcactaggcc 20 <210> 2864 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2864 ttcatggtcc tcatggatac 20 <210> 2865 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2865 aggatctccc agggctgccg 20 <210> 2866 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2866 aaggtaagtg taaaatggtc 20 <210> 2867 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2867 agcaccagac accagcccaa 20 <210> 2868 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2868 gaaaatgacc aactcactgg 20 <210> 2869 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2869 ggccctgttc aaacactata 20 <210> 2870 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2870 tcaggaggcc cttcaagctc 20 <210> 2871 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2871 aacatcgcca ttcccagagt 20 <210> 2872 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2872 ccgtgtcctc acacgctcct 20 <210> 2873 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2873 gaggcggtac atccacgggc 20 <210> 2874 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2874 gcagacgcat ccatttcctc 20 <210> 2875 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2875 acagcaaaca gcccagggtc 20 <210> 2876 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2876 agggcactca cctggatcgc 20 <210> 2877 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2877 cccaacttcc actttgcaaa 20 <210> 2878 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2878 cgtgtggtcc ccctcgccac 20 <210> 2879 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2879 tccctgtcca cacagggtca 20 <210> 2880 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2880 atatggctcc tactccacct 20 <210> 2881 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2881 cccataggtc aaaaagggcc 20 <210> 2882 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2882 cgaggcataa acacacttac 20 <210> 2883 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2883 accctgcttt cagctgggcc 20 <210> 2884 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2884 tcactaggcc tccatgcacc 20 <210> 2885 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2885 ccctaaacca ccactgcccc 20 <210> 2886 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2886 tctctggcca ccacaaggct 20 <210> 2887 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2887 gccacagatt ataacccaca 20 <210> 2888 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2888 gacaagagaa catctgtgcc 20 <210> 2889 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2889 ctcagcgaac ttaattatat 20 <210> 2890 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2890 ccctccccac ctactgcgga 20 <210> 2891 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2891 tcaaactctc ctagtgggtt 20 <210> 2892 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2892 cagatcttca tagcaaccca 20 <210> 2893 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2893 ggcacttcca ccttacccag 20 <210> 2894 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2894 ggcacacaac ccatgtgccc 20 <210> 2895 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2895 cccaagtccc ataagatgct 20 <210> 2896 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2896 tgccggaatc ctcaccctta 20 <210> 2897 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2897 gcagacagcc gacccagcct 20 <210> 2898 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2898 tgggctgtca ttacagtgtg 20 <210> 2899 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2899 ggctgtgaca cccagtgggt 20 <210> 2900 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2900 cccagaggca ccagcgggta 20 <210> 2901 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2901 acatgcgcac agaaatgaac 20 <210> 2902 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2902 ggcagagtgc ctactgcgca 20 <210> 2903 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2903 ctccactgcc ttgccacaca 20 <210> 2904 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2904 ggtgaatcaa agccaagccg 20 <210> 2905 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2905 agaaagccaa ttccagctca 20 <210> 2906 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2906 gcgccctgcc ccagacgcac 20 <210> 2907 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2907 cctctgagtc tccttcgggc 20 <210> 2908 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2908 ggctcaccca ccgtgatgat 20 <210> 2909 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2909 ccagactcac ccaaccctac 20 <210> 2910 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2910 tgtggctctc ccttgcagaa 20 <210> 2911 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2911 gacccaccat ctccccagaa 20 <210> 2912 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2912 tgcatctccc gatatagccc 20 <210> 2913 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2913 gtcagcggca tcactgtccc 20 <210> 2914 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2914 gcaggtgcct tcctttgccg 20 <210> 2915 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2915 ccgaccttta ctccaggcct 20 <210> 2916 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2916 cagcccaccc cagatggtcc 20 <210> 2917 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2917 gtgggcccca cctctgtccg 20 <210> 2918 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2918 catgcatccc ccgacataca 20 <210> 2919 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2919 accccagcac atcctggcct 20 <210> 2920 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2920 tcccagaccc ctcaccaaac 20 <210> 2921 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2921 gcaccaccac aaaaaggaga 20 <210> 2922 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2922 gggagatgcc tcccacttcc 20 <210> 2923 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2923 cccatggtgc ttcctagggc 20 <210> 2924 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2924 gcttcaggcc tttcgcacac 20 <210> 2925 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2925 agcagctgac tctcccgccc 20 <210> 2926 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2926 aattgctaaa ccacactttt 20 <210> 2927 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2927 accatcgccc cacactccac 20 <210> 2928 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2928 ccctctcatc ctatagacac 20 <210> 2929 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2929 agctccatta cctctgctct 20 <210> 2930 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2930 tgaccagacc ccagaatctc 20 <210> 2931 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2931 agacatcccc accgcaaccc 20 <210> 2932 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2932 gctccagcct ttccgtggac 20 <210> 2933 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2933 cgctgtctaa tcagctccca 20 <210> 2934 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2934 atattcaatc aacttaggac 20 <210> 2935 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2935 tgaaagaccc tctctggtct 20 <210> 2936 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2936 gcatgtcacc ccaccagcag 20 <210> 2937 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2937 cctgccagaa cttttggaca 20 <210> 2938 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2938 gggtcagccc acaagcctca 20 <210> 2939 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2939 gaagactccc ctgagcctct 20

Claims (54)

An oligomeric compound comprising a modified oligonucleotide consisting of 12 to 50 linked nucleosides, wherein the nucleobase sequence of the modified oligonucleotide is at least the same length as that of a potassium sodium-activated channel subfamily T member 1 (KCNT1) nucleic acid. An oligomeric compound that is 90% complementary and wherein the modified oligonucleotide comprises at least one modification selected from a modified sugar moiety and a modified internucleoside linkage. An oligomeric compound comprising a modified oligonucleotide, wherein the modified oligonucleotide consists of 12 to 50 linked nucleosides and comprises at least 8, 9, 10, 11, 12, 13 of any of SEQ ID NOs: 21-2939; An oligomeric compound having a nucleobase sequence comprising 14, 15, 16, 17, 18, 19 or 20 contiguous nucleobases. An oligomeric compound comprising a modified oligonucleotide, wherein the modified oligonucleotide consists of 12 to 50 linked nucleosides,
The same length portion of nucleobases 24523 to 24561 of SEQ ID NO: 2,
The same length portion of nucleobases 27568 to 27603 of SEQ ID NO: 2,
The same length portion of nucleobases 30772 to 30811 of SEQ ID NO: 2,
The same length portion of nucleobases 54372 to 54428 of SEQ ID NO: 2,
The same length portion of nucleobases 55785 to 55818 of SEQ ID NO: 2,
The same length portion of nucleobases 56048 to 56073 of SEQ ID NO: 2,
The same length portion of nucleobases 56319 to 56349 of SEQ ID NO: 2,
The same length portion of nucleobases 57683 to 57710 of SEQ ID NO: 2,
The same length portion of nucleobases 61117 to 61153 of SEQ ID NO: 2,
The same length portion of nucleobases 71033 to 71060 of SEQ ID NO: 2,
the same length portion of nucleobases 87135 to 87174 of SEQ ID NO: 2,
the same length portion of nucleobases 92109 to 92149 of SEQ ID NO: 2;
The same length portion of nucleobases 94221 to 94280 of SEQ ID NO: 2,
The same length portion of nucleobases 94352 to 94380 of SEQ ID NO: 2,
the same length portion of nucleobases 94993 to 95036 of SEQ ID NO: 2,
at least 8, at least 9, at least 10, at least 11, at least 12, at least 13, at least 14, at least 15, at least 16 complementary to the same length portion of nucleobases 95074 to 95144 of SEQ ID NO: 2 An oligomeric compound having a nucleobase sequence comprising at least 17, at least 18, at least 19 or at least 20 contiguous nucleobases. An oligomeric compound comprising a modified oligonucleotide, wherein the modified oligonucleotide consists of 12 to 50 linked nucleosides,
the same length portion of nucleobases 16586 to 16649 of SEQ ID NO: 2,
The same length portion of nucleobases 16586 to 17823 of SEQ ID NO: 2,
The same length portion of nucleobases 16586 to 18663 of SEQ ID NO: 2,
The same length portion of nucleobases 19220 to 20568 of SEQ ID NO: 2,
The same length portion of nucleobases 23003 to 25391 of SEQ ID NO: 2,
the same length portion of nucleobases 27095 to 29908 of SEQ ID NO: 2,
The same length portion of nucleobases 30452 to 30891 of SEQ ID NO: 2,
The same length portion of nucleobases 31773 to 34427 of SEQ ID NO: 2,
the same length portion of nucleobases 38458 to 47003 of SEQ ID NO: 2,
The same length portion of nucleobases 40432 to 42873 of SEQ ID NO: 2,
The same length portion of nucleobases 44414 to 45718 of SEQ ID NO: 2,
The same length portion of nucleobases 52096 to 52153 of SEQ ID NO: 2,
the same length portion of nucleobases 52096 to 58525 of SEQ ID NO: 2,
The same length portion of nucleobases 59308 to 61697 of SEQ ID NO: 2,
The same length portion of nucleobases 60111 to 61697 of SEQ ID NO: 2,
The same length portion of nucleobases 65270 to 67169 of SEQ ID NO: 2,
The same length portion of nucleobases 65270 to 67150 of SEQ ID NO: 2,
The same length portion of nucleobases 67026 to 67065 of SEQ ID NO: 2,
The same length portion of nucleobases 67026 to 67087 of SEQ ID NO: 2,
The same length portion of nucleobases 67648 to 68527 of SEQ ID NO: 2,
The same length portion of nucleobases 67955 to 67998 of SEQ ID NO: 2,
The same length portion of nucleobases 68515 to 68583 of SEQ ID NO: 2,
The same length portion of nucleobases 68538 to 68592 of SEQ ID NO: 2,
The same length portion of nucleobases 68571 to 70874 of SEQ ID NO: 2,
The same length portion of nucleobases 71037 to 71313 of SEQ ID NO: 2,
The same length portion of nucleobases 71037 to 71184 of SEQ ID NO: 2,
The same length portion of nucleobases 72851 to 72887 of SEQ ID NO: 2,
The same length portion of nucleobases 79368 to 79483 of SEQ ID NO: 2,
The same length portion of nucleobases 86554 to 90150 of SEQ ID NO: 2,
the same length portion of nucleobases 88332 to 88448 of SEQ ID NO: 2,
The same length portion of nucleobases 91686 to 95485 of SEQ ID NO: 2,
the same length portion of nucleobases 91686 to 94431 of SEQ ID NO: 2 or
at least 8, at least 9, at least 10, at least 11, at least 12, at least 13, at least 14, at least 15, at least 16 complementary to the same length portion of nucleobases 94219 to 94275 of SEQ ID NO:2 An oligomeric compound having a nucleobase sequence comprising at least 17, at least 18, at least 19 or at least 20 contiguous nucleobases. 5. The modified oligonucleotide according to any one of claims 1 to 4, wherein the modified oligonucleotide comprises at least a portion of the same length of a nucleobase sequence selected from SEQ ID NOs: 1 to 3 as measured over the entire nucleobase sequence of the modified oligonucleotide. An oligomeric compound having nucleobases that are 80%, 85%, 90%, 95% or 100% complementary. 6. The oligomeric compound of any one of claims 1-5, wherein at least one modified nucleoside comprises a modified sugar moiety. 7. The oligomeric compound of claim 6, wherein the modified sugar moiety comprises a bicyclic sugar moiety. 8. The method of claim 7, wherein the bicyclic sugar moiety is -O-CH ₂ -; and a 2′-4′ bridge selected from —O—CH(CH _{3 )—.} 7. The oligomeric compound of claim 6, wherein the modified sugar moiety comprises a non-bicyclic modified sugar moiety. 10. The oligomeric compound of claim 9, wherein the non-bicyclic modified sugar moiety comprises a 2'-MOE sugar moiety or a 2'-OMe sugar moiety. 6. The oligomeric compound of any one of claims 1-5, wherein at least one modified nucleoside comprises a sugar surrogate. 12. The oligomeric compound of claim 11, wherein the sugar surrogate is selected from morpholino and PNA. 13. The method of any one of claims 1 to 12, wherein the modified oligonucleotide comprises:
a 5'-region consisting of 1 to 5 linked 5'-region nucleosides;
a central region consisting of 6 to 10 linked central region nucleosides; and
a 3'-region consisting of 1 to 5 linked 3'-region nucleosides;
each of the 5'-region nucleosides and each of the 3'-region nucleosides comprises a modified sugar moiety, and each of the central region nucleosides comprises an unmodified 2'-deoxyribosyl sugar moiety. comprising, an oligomeric compound. 14. The oligomeric compound of any one of claims 1-13, wherein the modified oligonucleotide comprises at least one modified internucleoside linkage. 15. The oligomeric compound of claim 14, wherein each internucleoside linkage of the modified oligonucleotide is a modified internucleoside linkage. 16. The oligomeric compound of claim 14 or 15, wherein the modified internucleoside linkage is a phosphorothioate internucleoside linkage. 17. The oligomeric compound of claim 14 or 16, wherein the modified oligonucleotide comprises at least one phosphodiester internucleoside linkage. 18. The method of any one of claims 14, 16 and 17, wherein each internucleoside linkage is independently selected from a phosphodiester internucleoside linkage or a phosphorothioate internucleoside linkage. oligomeric compounds. 19. The oligomeric compound of any one of claims 1-18, wherein the modified oligonucleotide comprises at least one modified nucleobase. 20. The oligomeric compound of claim 19, wherein the modified nucleobase is 5-methyl cytosine. 21. The method of any one of claims 1 to 20, wherein the modified oligonucleotides are 12 to 30, 12 to 22, 12 to 20, 14 to 20, 15 to 25, 16 to 20, An oligomeric compound consisting of 18 to 22 or 18 to 20 linked nucleosides. 22. The oligomeric compound of any one of claims 1-21, wherein the modified oligonucleotide consists of 20 linked nucleosides. 23. The method of claim 22, wherein the modified oligonucleotide has the internucleoside linkage motif soooosssssssssssooss, "s" represents phosphorothioate internucleoside linkage, and "o" is phosphodiester internucleoside linkage. An oligomeric compound representing a linkage. 24. An oligomeric compound according to any one of claims 1 to 23 consisting of said modified oligonucleotide. 24. An oligomeric compound according to any one of claims 1 to 23 comprising a conjugate group comprising a conjugate moiety and a conjugate linker. 26. The oligomeric compound of claim 25, wherein the conjugate group comprises a GalNAc cluster comprising 1 to 3 GalNAc ligands. 27. The oligomeric compound of claim 25 or 26, wherein the conjugate linker consists of a single bond. 26. The oligomeric compound of claim 25, wherein the conjugate linker is cleavable. 29. The oligomeric compound of claim 28, wherein the conjugate linker comprises 1 to 3 linker-nucleosides. 30. The oligomeric compound of any one of claims 25-29, wherein the conjugate group is conjugated to the modified oligonucleotide at the 5'-end of the modified oligonucleotide. 30. The oligomeric compound of any one of claims 25-29, wherein the conjugate group is conjugated to the modified oligonucleotide at the 3'-end of the modified oligonucleotide. 32. The oligomeric compound of any one of claims 1-31, comprising terminal groups. 33. The oligomeric compound of any one of claims 1-32, wherein the oligomeric compound is a single-stranded oligomeric compound. 32. The oligomeric compound of any one of claims 1-28, 30 or 31, wherein the oligomeric compound does not comprise a linker-nucleoside. 35. The oligomeric compound of any one of claims 1-34, wherein the modified oligonucleotide of the oligomeric compound is a salt, and the salt is a sodium salt or a potassium salt. 36. An oligomeric duplex comprising the oligomeric compound of any one of claims 1-32, 34 and 35. 36. An antisense compound comprising or consisting of the oligomeric compound of any one of claims 1-35 or the oligomeric duplex of claim 36. 36. A pharmaceutical composition comprising the oligomeric compound of any one of claims 1-35 or the oligomeric duplex of claim 36 and a pharmaceutically acceptable carrier or diluent. 39. The pharmaceutical composition of claim 38, wherein the pharmaceutically acceptable diluent is artificial spinal fluid or PBS. 40. The pharmaceutical composition of claim 39, wherein the pharmaceutical composition consists essentially of the modified oligonucleotide and artificial spinal fluid. 41. A method comprising administering to a subject the pharmaceutical composition of any one of claims 38-40. 41. A method of treating a neurological condition, comprising: administering to a subject having or at risk of developing said neurological condition a therapeutically effective amount of the pharmaceutical composition of any one of claims 38-40; and thereby treating the neurological condition. 41. A method of reducing KCNT1 RNA or KCNT1 protein in the central nervous system of an individual having or at risk of developing a neurological condition, comprising administering a therapeutically effective amount of the pharmaceutical composition according to any one of claims 38 to 40 step; and thereby reducing KCNT1 RNA or KCNT1 protein in the central nervous system. 44. The method of claim 42 or 43, wherein the neurological condition comprises encephalopathy. 44. The method of claim 42 or 43, wherein the neurological condition comprises epilepsy. 44. The method of claim 42 or 43, wherein the neurological condition comprises infantile epilepsy. 47. The method of claim 46, wherein the infantile epilepsy is epilepsy of infancy with migrating focal seizures (EIMFS). 44. The method of claim 42 or 43, wherein the neurological condition is autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE). 49. The method of any one of claims 41-48, wherein the administration is by intrathecal administration. 50. The method of any one of claims 42-49, wherein the symptom or characteristic of at least one of the neurological conditions is improved. 51. The method of claim 50, wherein the symptom or characteristic is selected from seizures, brain damage, demyelination, decreased muscle function, microcephaly, depression, anxiety, cognitive function. 52. The method of any one of claims 42-51, wherein the method prevents or slows disease regression. A method of reducing KCNT1 RNA in a cell, comprising: contacting said cell with an oligomeric compound according to any one of claims 1-35, an oligomeric duplex according to claim 36 or an antisense compound according to claim 37; and thereby reducing KCNT1 RNA in said cell. A method of reducing KCNT1 protein in a cell, comprising: contacting said cell with an oligomeric compound according to any one of claims 1-35, an oligomeric duplex according to claim 36 or an antisense compound according to claim 37; and thereby reducing KCNT1 protein in said cell.