BR112021018335A2 - Derivados de benzodiazepina como inibidores de rsv - Google Patents

Derivados de benzodiazepina como inibidores de rsv

Info

Publication number
BR112021018335A2
BR112021018335A2 BR112021018335A BR112021018335A BR112021018335A2 BR 112021018335 A2 BR112021018335 A2 BR 112021018335A2 BR 112021018335 A BR112021018335 A BR 112021018335A BR 112021018335 A BR112021018335 A BR 112021018335A BR 112021018335 A2 BR112021018335 A2 BR 112021018335A2
Authority
BR
Brazil
Prior art keywords
rsv
present
benzodiazepine derivatives
compounds
inhibitors
Prior art date
Application number
BR112021018335A
Other languages
English (en)
Inventor
Adam Szymaniak
Jong Kim In
Jianming Yu
Kaicheng Zhu
Kevin Mcgrath
Solymar Negretti-Emmanuelli
Sun Or Yat
Original Assignee
Enanta Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enanta Pharm Inc filed Critical Enanta Pharm Inc
Publication of BR112021018335A2 publication Critical patent/BR112021018335A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

derivados de benzodiazepina como inibidores de rsv. a presente invenção revela compostos de fórmula (i) ou sais farmaceuticamente aceitáveis, ésteres ou pró-fármacos dos mesmos: que inibem vírus sincicial respiratório (rsv). a presente invenção se refere adicionalmente a composições farmacêuticas compreendendo os compostos supracitados para administração a um indivíduo que sofre de infecção por rsv. a presente invenção também se refere a métodos para tratar uma infecção por rsv em um indivíduo ao administrar uma composição farmacêutica que compreende os compostos da presente invenção.
BR112021018335A 2019-03-18 2020-03-17 Derivados de benzodiazepina como inibidores de rsv BR112021018335A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962819915P 2019-03-18 2019-03-18
US201962821094P 2019-03-20 2019-03-20
PCT/US2020/023135 WO2020190935A1 (en) 2019-03-18 2020-03-17 Benzodiazepine derivatives as rsv inhibitors

Publications (1)

Publication Number Publication Date
BR112021018335A2 true BR112021018335A2 (pt) 2021-11-23

Family

ID=72514103

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021018335A BR112021018335A2 (pt) 2019-03-18 2020-03-17 Derivados de benzodiazepina como inibidores de rsv

Country Status (14)

Country Link
US (2) US11254664B2 (pt)
EP (1) EP3941525A4 (pt)
JP (1) JP7558189B2 (pt)
KR (1) KR20210138684A (pt)
CN (1) CN113710276B (pt)
AU (1) AU2020240024A1 (pt)
BR (1) BR112021018335A2 (pt)
CA (1) CA3133300A1 (pt)
IL (1) IL286363A (pt)
MX (1) MX2021011144A (pt)
SG (1) SG11202110137VA (pt)
TW (1) TW202102493A (pt)
UY (1) UY38614A (pt)
WO (1) WO2020190935A1 (pt)

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Publication number Publication date
KR20210138684A (ko) 2021-11-19
EP3941525A4 (en) 2022-12-07
CA3133300A1 (en) 2020-09-24
CN113710276A (zh) 2021-11-26
US11912695B2 (en) 2024-02-27
SG11202110137VA (en) 2021-10-28
CN113710276B (zh) 2024-03-29
WO2020190935A1 (en) 2020-09-24
AU2020240024A1 (en) 2021-10-14
US20220227746A1 (en) 2022-07-21
JP2022525893A (ja) 2022-05-20
EP3941525A1 (en) 2022-01-26
IL286363A (en) 2021-10-31
MX2021011144A (es) 2022-01-18
UY38614A (es) 2020-10-30
US20200299286A1 (en) 2020-09-24
US11254664B2 (en) 2022-02-22
TW202102493A (zh) 2021-01-16
JP7558189B2 (ja) 2024-09-30

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