MX2021011144A - Derivados de las benzodiazepinas como inhibidores del vsr. - Google Patents

Derivados de las benzodiazepinas como inhibidores del vsr.

Info

Publication number
MX2021011144A
MX2021011144A MX2021011144A MX2021011144A MX2021011144A MX 2021011144 A MX2021011144 A MX 2021011144A MX 2021011144 A MX2021011144 A MX 2021011144A MX 2021011144 A MX2021011144 A MX 2021011144A MX 2021011144 A MX2021011144 A MX 2021011144A
Authority
MX
Mexico
Prior art keywords
present
rsv
compounds
benzodiazepine derivatives
rsv inhibitors
Prior art date
Application number
MX2021011144A
Other languages
English (en)
Inventor
In Jong Kim
Yat Sun Or
Jianming Yu
Kaicheng Zhu
Kevin Mcgrath
Solymar Negretti-Emmanuelli
Adam Szymaniak
Original Assignee
Enanta Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enanta Pharm Inc filed Critical Enanta Pharm Inc
Publication of MX2021011144A publication Critical patent/MX2021011144A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención describe compuestos de Fórmula (I), o sales farmacéuticamente aceptables, ésteres o profármacos de los mismos: (Ver Fórmula I), que inhiben el Virus Sincitial Respiratorio (VSR). La presente invención se refiere además a composiciones farmacéuticas que comprenden los compuestos antes mencionados para la administración a un sujeto que padece de infección por VSR. La invención se refiere además a métodos para tratar una infección por VSR en un sujeto mediante la administración de una composición farmacéutica que comprende los compuestos de la presente invención.
MX2021011144A 2019-03-18 2020-03-17 Derivados de las benzodiazepinas como inhibidores del vsr. MX2021011144A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962819915P 2019-03-18 2019-03-18
US201962821094P 2019-03-20 2019-03-20
PCT/US2020/023135 WO2020190935A1 (en) 2019-03-18 2020-03-17 Benzodiazepine derivatives as rsv inhibitors

Publications (1)

Publication Number Publication Date
MX2021011144A true MX2021011144A (es) 2022-01-18

Family

ID=72514103

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021011144A MX2021011144A (es) 2019-03-18 2020-03-17 Derivados de las benzodiazepinas como inhibidores del vsr.

Country Status (14)

Country Link
US (2) US11254664B2 (es)
EP (1) EP3941525A4 (es)
JP (1) JP2022525893A (es)
KR (1) KR20210138684A (es)
CN (1) CN113710276B (es)
AU (1) AU2020240024A1 (es)
BR (1) BR112021018335A2 (es)
CA (1) CA3133300A1 (es)
IL (1) IL286363A (es)
MX (1) MX2021011144A (es)
SG (1) SG11202110137VA (es)
TW (1) TW202102493A (es)
UY (1) UY38614A (es)
WO (1) WO2020190935A1 (es)

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* Cited by examiner, † Cited by third party
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Also Published As

Publication number Publication date
BR112021018335A2 (pt) 2021-11-23
JP2022525893A (ja) 2022-05-20
EP3941525A1 (en) 2022-01-26
US20220227746A1 (en) 2022-07-21
WO2020190935A1 (en) 2020-09-24
AU2020240024A1 (en) 2021-10-14
US11254664B2 (en) 2022-02-22
TW202102493A (zh) 2021-01-16
CN113710276B (zh) 2024-03-29
KR20210138684A (ko) 2021-11-19
SG11202110137VA (en) 2021-10-28
US11912695B2 (en) 2024-02-27
CN113710276A (zh) 2021-11-26
US20200299286A1 (en) 2020-09-24
UY38614A (es) 2020-10-30
CA3133300A1 (en) 2020-09-24
IL286363A (en) 2021-10-31
EP3941525A4 (en) 2022-12-07

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