DE60035591D1 - Thiazepin-hemmer von hiv-1 integrase - Google Patents

Thiazepin-hemmer von hiv-1 integrase

Info

Publication number
DE60035591D1
DE60035591D1 DE60035591T DE60035591T DE60035591D1 DE 60035591 D1 DE60035591 D1 DE 60035591D1 DE 60035591 T DE60035591 T DE 60035591T DE 60035591 T DE60035591 T DE 60035591T DE 60035591 D1 DE60035591 D1 DE 60035591D1
Authority
DE
Germany
Prior art keywords
compounds
hiv
integrase
hemmer
thiazepine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60035591T
Other languages
English (en)
Inventor
Nouri Neamati
Yves Pommier
Antonio Garofalo
Vito Nacci
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Application granted granted Critical
Publication of DE60035591D1 publication Critical patent/DE60035591D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
DE60035591T 1999-05-12 2000-05-10 Thiazepin-hemmer von hiv-1 integrase Expired - Lifetime DE60035591D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13372699P 1999-05-12 1999-05-12
PCT/US2000/012847 WO2000068235A1 (en) 1999-05-12 2000-05-10 Thiazepine inhibitors of hiv-1 integrase

Publications (1)

Publication Number Publication Date
DE60035591D1 true DE60035591D1 (de) 2007-08-30

Family

ID=22460029

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60035591T Expired - Lifetime DE60035591D1 (de) 1999-05-12 2000-05-10 Thiazepin-hemmer von hiv-1 integrase

Country Status (6)

Country Link
EP (1) EP1187837B1 (de)
AT (1) ATE367393T1 (de)
AU (1) AU777036B2 (de)
CA (1) CA2372791A1 (de)
DE (1) DE60035591D1 (de)
WO (1) WO2000068235A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002102808A2 (en) 2001-06-14 2002-12-27 Akzo Nobel N.V. (PYRIDO/THIENO)-[f]-OXAZEPIN-5-ONE DERIVATIVES AS POSITIVE MODULATORS OF THE AMPA RECEPTOR
PA8586801A1 (es) * 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
ES2292123T3 (es) * 2004-04-26 2008-03-01 Pfizer Inc. Inhibidores de la enzima integrasa de vih.
JP2007534739A (ja) 2004-04-26 2007-11-29 ファイザー・インク ピロロピリジン誘導体及びｈｉｖインテグラーゼ酵素阻害剤としてのその使用
EP1873155A1 (de) * 2004-04-26 2008-01-02 Pfizer Inc. Hemmer des HIV-Integrase-Enzyms

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4045448A (en) * 1976-02-26 1977-08-30 American Hoechst Corporation Pyrrolo[2,1-c][1,4]benzoxazepine and benzoxazocine derivatives
EP0949926A4 (de) * 1996-10-31 2001-01-17 Merck & Co Inc Benzodiazepin hydrozidderivate als hiv-interase inhibitoren

Also Published As

Publication number Publication date
WO2000068235A1 (en) 2000-11-16
CA2372791A1 (en) 2000-11-16
AU777036B2 (en) 2004-09-30
EP1187837B1 (de) 2007-07-18
ATE367393T1 (de) 2007-08-15
AU5002100A (en) 2000-11-21
EP1187837A1 (de) 2002-03-20

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Legal Events

Date Code Title Description
8332 No legal effect for de