NO20051833L - 4-(3,5-dicyanofenoksy)pyrazolderivater for anvendelse som transkriptasemodulatorer ved behandling av IA HIV. - Google Patents

4-(3,5-dicyanofenoksy)pyrazolderivater for anvendelse som transkriptasemodulatorer ved behandling av IA HIV.

Info

Publication number
NO20051833L
NO20051833L NO20051833A NO20051833A NO20051833L NO 20051833 L NO20051833 L NO 20051833L NO 20051833 A NO20051833 A NO 20051833A NO 20051833 A NO20051833 A NO 20051833A NO 20051833 L NO20051833 L NO 20051833L
Authority
NO
Norway
Prior art keywords
compounds
hiv
treatment
pyrazole derivatives
dicyanophenoxy
Prior art date
Application number
NO20051833A
Other languages
English (en)
Inventor
David Anthony Price
Matthew Duncan Selby
Paul Anthony Stupple
Charles Eric Mowbary
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO20051833L publication Critical patent/NO20051833L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/29—Saturated compounds containing keto groups bound to rings
    • C07C49/293—Saturated compounds containing keto groups bound to rings to a three- or four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/29—Saturated compounds containing keto groups bound to rings
    • C07C49/327—Saturated compounds containing keto groups bound to rings containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Det beskrives pyrazolderivater med formel (I) og farmasøytisk akseptable salter, solvater eller derivater derav. Videre beskrives forbindelsenes anvendelse i medisin, preparater inneholdende forbindelser, fremgangsmåter for fremstilling av disse forbindelser, samt mellomprodukter til bruk i disse prosesser. De beskrevne forbindelser binder til enzymet reverstranskriptase og er modulatorer og særlig inhibitorer av disse. Reverstranskriptase er implikert i den infeksiøse levesyklus for humanimmundefekt virus (HIV). Forbindelser som interferer med funksjonen av dette enzymet har vist anvendelighet ved behandling av tilstander forårsaket av HIV og genetisk relaterte retrovirus som ervervet immundefektsyndrom (AIDS).
NO20051833A 2002-09-16 2005-04-15 4-(3,5-dicyanofenoksy)pyrazolderivater for anvendelse som transkriptasemodulatorer ved behandling av IA HIV. NO20051833L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0221477.3A GB0221477D0 (en) 2002-09-16 2002-09-16 Chemical compounds
GBGB0223354.2A GB0223354D0 (en) 2002-09-16 2002-10-08 Chemical compounds
PCT/IB2003/003946 WO2004024147A1 (en) 2002-09-16 2003-09-08 4-(3,5-dicyanophenoxy) pyrazole derivatives for use as transcriptase modulators in the treatment of i.a. hiv

Publications (1)

Publication Number Publication Date
NO20051833L true NO20051833L (no) 2005-06-14

Family

ID=31995706

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20051833A NO20051833L (no) 2002-09-16 2005-04-15 4-(3,5-dicyanofenoksy)pyrazolderivater for anvendelse som transkriptasemodulatorer ved behandling av IA HIV.

Country Status (20)

Country Link
EP (1) EP1542679B1 (no)
JP (1) JP2006504792A (no)
KR (1) KR20050043962A (no)
CN (1) CN1681494A (no)
AP (1) AP2005003248A0 (no)
AU (1) AU2003263422A1 (no)
BR (1) BR0314243A (no)
CA (1) CA2496315A1 (no)
DE (1) DE60311284T2 (no)
EA (1) EA200500287A1 (no)
EC (1) ECSP055673A (no)
GB (2) GB0221477D0 (no)
HR (1) HRP20050222A2 (no)
IS (1) IS7705A (no)
MA (1) MA27435A1 (no)
MX (1) MXPA05002963A (no)
NO (1) NO20051833L (no)
OA (1) OA12920A (no)
PL (1) PL375976A1 (no)
WO (1) WO2004024147A1 (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005100322A1 (en) * 2004-04-14 2005-10-27 Pfizer Limited Sulphur-linked imidazole compounds for the treament of hiv
DE102008015032A1 (de) 2008-03-17 2009-09-24 Aicuris Gmbh & Co. Kg Substituierte Pyrazolamide und ihre Verwendung
DE102008015033A1 (de) 2008-03-17 2009-09-24 Aicuris Gmbh & Co. Kg Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung
DE102008062863A1 (de) 2008-12-17 2010-06-24 Aicuris Gmbh & Co. Kg Substituierte (Thiophenyl-carbonyl)imidazolidinone und ihre Verwendung
DE102008062878A1 (de) 2008-12-17 2010-06-24 Aicuris Gmbh & Co. Kg Substituierte Furancarboxamide und ihre Verwendung

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3303200A (en) * 1963-11-05 1967-02-07 American Home Prod Pyrazole-1-ethanol derivatives
GB0016787D0 (en) * 2000-07-07 2000-08-30 Pfizer Ltd Compounds useful in therapy
EP1377556B1 (en) * 2001-04-10 2007-04-04 Pfizer Limited Pyrazole derivatives for treating hiv

Also Published As

Publication number Publication date
OA12920A (en) 2006-10-13
WO2004024147A1 (en) 2004-03-25
JP2006504792A (ja) 2006-02-09
ECSP055673A (es) 2005-07-06
EP1542679A1 (en) 2005-06-22
KR20050043962A (ko) 2005-05-11
BR0314243A (pt) 2005-07-26
MA27435A1 (fr) 2005-07-01
GB0223354D0 (en) 2002-11-13
PL375976A1 (en) 2005-12-12
AU2003263422A1 (en) 2004-04-30
CN1681494A (zh) 2005-10-12
DE60311284T2 (de) 2007-06-21
IS7705A (is) 2005-02-21
GB0221477D0 (en) 2002-10-23
EA200500287A1 (ru) 2005-10-27
CA2496315A1 (en) 2004-03-25
DE60311284D1 (de) 2007-03-08
MXPA05002963A (es) 2005-05-27
EP1542679B1 (en) 2007-01-17
AP2005003248A0 (en) 2005-03-31
HRP20050222A2 (en) 2005-10-31

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