NO20065582L - (1,lOB-dihydro-2-(amtnokarbonyl-fenyl)-SH-pyrazolo[1,5-C][1,3]benzoksazin-5-yl)fenylmetanonderivater som HIV-virusreplikasjonsinhibitorer - Google Patents

(1,lOB-dihydro-2-(amtnokarbonyl-fenyl)-SH-pyrazolo[1,5-C][1,3]benzoksazin-5-yl)fenylmetanonderivater som HIV-virusreplikasjonsinhibitorer

Info

Publication number
NO20065582L
NO20065582L NO20065582A NO20065582A NO20065582L NO 20065582 L NO20065582 L NO 20065582L NO 20065582 A NO20065582 A NO 20065582A NO 20065582 A NO20065582 A NO 20065582A NO 20065582 L NO20065582 L NO 20065582L
Authority
NO
Norway
Prior art keywords
benzoxazin
pyrazolo
aminocarbonyl
dihydro
phenyl
Prior art date
Application number
NO20065582A
Other languages
English (en)
Inventor
Dominique Louis Nest Surleraux
Abdellah Tahri
Lieve Emma Jan Michiels
Koenraad Lodewijk August Acker
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of NO20065582L publication Critical patent/NO20065582L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Abstract

Foreliggende oppfinnelse vedrører 5H-pyrazolo[l,5-c][l,3]benzoksazin-5-yl)fenylmetanonderivater som inhibitorer av vimsreplikasjonen av HIV-vimset, fremgangsmåter for deres fremstilling samt farmasøytiske sammensetninger, deres anvendelse som legemidler og diagnostiske kit omfattende dem. Foreliggende oppfinnelse vedrører også kombinasjoner av foreliggende oppfinnelse HTV-inhibitorer med andre antirefrovimsmidler. Den vedrører ytterligere deres anvendelse i assayer som referanseforbindelser eller som reagenser. Forbindelsene ifølge foreliggende oppfinnelse er nyttige for å forhindre eller behandle infeksjon med HTV og for å behandle AIDS.
NO20065582A 2004-05-04 2006-12-04 (1,lOB-dihydro-2-(amtnokarbonyl-fenyl)-SH-pyrazolo[1,5-C][1,3]benzoksazin-5-yl)fenylmetanonderivater som HIV-virusreplikasjonsinhibitorer NO20065582L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04101913 2004-05-04
US60427504P 2004-08-25 2004-08-25
PCT/EP2005/052041 WO2005105810A2 (en) 2004-05-04 2005-05-04 (1,10b-dihydro-2-(aminocarbonyl-phenyl)-5h-pyrazolo[1,5- c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as hiv viral replication inhibitors

Publications (1)

Publication Number Publication Date
NO20065582L true NO20065582L (no) 2006-12-04

Family

ID=35058129

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20065582A NO20065582L (no) 2004-05-04 2006-12-04 (1,lOB-dihydro-2-(amtnokarbonyl-fenyl)-SH-pyrazolo[1,5-C][1,3]benzoksazin-5-yl)fenylmetanonderivater som HIV-virusreplikasjonsinhibitorer

Country Status (20)

Country Link
US (1) US7326703B2 (no)
EP (1) EP1778696B1 (no)
JP (1) JP4929162B2 (no)
KR (1) KR20070015547A (no)
CN (1) CN1950380B (no)
AP (1) AP2006003759A0 (no)
AR (1) AR048650A1 (no)
AT (1) ATE389660T1 (no)
AU (1) AU2005238235B2 (no)
BR (1) BRPI0510612A (no)
CA (1) CA2563959C (no)
DE (1) DE602005005490T2 (no)
ES (1) ES2303244T3 (no)
IL (1) IL178082A (no)
MX (1) MXPA06012755A (no)
NO (1) NO20065582L (no)
PL (1) PL1778696T3 (no)
RU (1) RU2382789C2 (no)
WO (1) WO2005105810A2 (no)
ZA (1) ZA200609178B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7122185B2 (en) 2002-02-22 2006-10-17 Progenics Pharmaceuticals, Inc. Anti-CCR5 antibody
TW200710091A (en) * 2005-04-11 2007-03-16 Tibotec Pharm Ltd (1,10B-dihydro-2-(aminoalkyl-phenyl)-5H-pyrazolo [1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as HIV viral replication inhibitors
AU2006272750B2 (en) * 2005-07-22 2011-09-29 Cytodyn, Inc. Methods for reducing viral load in HIV-1-infected patients
US20100190809A1 (en) * 2007-06-25 2010-07-29 Jody Firmin Voorspoels Combination formulations
US8592487B2 (en) * 2007-10-26 2013-11-26 Concert Pharmaceuticals, Inc. Deuterated darunavir
WO2009134401A2 (en) * 2008-04-29 2009-11-05 Progenics Pharmaceuticals, Inc. Methods of inhibiting infection by diverse subtypes of drug-resistant hiv-1

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
DE4210939A1 (de) * 1992-04-02 1993-10-07 Bayer Ag Verwendung von 7-Oxo-7H-pyrido[1,2,3-de][1,4]benzoxacin-6-carbonsäuren und -estern als Arzneimittel
PH30929A (en) 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
PT721331E (pt) 1993-10-01 2002-05-31 Astrazeneca Ab Processo i
CA2240161C (en) 1996-05-20 2005-05-24 Janssen Pharmaceutica N.V. Antifungal compositions with improved bioavailability
CA2268953A1 (en) * 1996-10-02 1998-04-09 Du Pont Pharmaceuticals Company 4,4-disubstituted-1,4-dihydro-2h-3,1-benzoxazin-2-ones useful as hiv reverse transcriptase inhibitors and intermediates and processes for making the same
ID21477A (id) 1997-03-26 1999-06-17 Janssen Pharmaceutica Nv Pelet-pelet yang mempunyai inti yang dilapisi dengan suatu anti jamur dan suatu polimer
HUP0102117A2 (hu) * 1998-05-20 2001-12-28 Eli Lilly And Co. Imidazo[1,2-a]piridin-származékok és ezeket tartalmazó gyógyászati készítmények
CZ305099B6 (cs) * 2001-04-10 2015-05-06 Pfizer Inc. Derivát pyrazolu, způsoby a meziprodukty pro výrobu, farmaceutická kompozice s jeho obsahem a jeho lékařské aplikace, zejména k léčení infekcí HIV

Also Published As

Publication number Publication date
CN1950380A (zh) 2007-04-18
RU2382789C2 (ru) 2010-02-27
CA2563959A1 (en) 2005-11-10
IL178082A0 (en) 2006-12-31
ZA200609178B (en) 2008-08-27
US20070248624A1 (en) 2007-10-25
PL1778696T3 (pl) 2008-08-29
JP2007536346A (ja) 2007-12-13
EP1778696A2 (en) 2007-05-02
DE602005005490D1 (de) 2008-04-30
IL178082A (en) 2012-06-28
ATE389660T1 (de) 2008-04-15
CN1950380B (zh) 2010-12-08
KR20070015547A (ko) 2007-02-05
CA2563959C (en) 2014-07-15
AU2005238235B2 (en) 2011-07-07
AU2005238235A1 (en) 2005-11-10
EP1778696B1 (en) 2008-03-19
WO2005105810A3 (en) 2006-03-02
RU2006142705A (ru) 2008-06-20
US7326703B2 (en) 2008-02-05
DE602005005490T2 (de) 2009-04-23
JP4929162B2 (ja) 2012-05-09
AP2006003759A0 (en) 2006-10-31
BRPI0510612A (pt) 2007-10-30
ES2303244T3 (es) 2008-08-01
WO2005105810A2 (en) 2005-11-10
MXPA06012755A (es) 2007-01-16
AR048650A1 (es) 2006-05-10

Similar Documents

Publication Publication Date Title
NO20072235L (no) HCV-hemmende bicykliske pyrimidiner
WO2001029037A3 (en) Condensed naphthyridines as hiv reverse transcriptase inhibitors
NO20054905L (no) 2-acylamino-4-fenyltiazolderivater, fremgangsmate for deres fremstilling og anvendelse av de samme som i terapeutika
ATE552261T1 (de) Pyrazol-ä1,5-aü pyrimidine als proteinkinasehemmer
NO20065582L (no) (1,lOB-dihydro-2-(amtnokarbonyl-fenyl)-SH-pyrazolo[1,5-C][1,3]benzoksazin-5-yl)fenylmetanonderivater som HIV-virusreplikasjonsinhibitorer
NO20064584L (no) Tetrahydropyridoindolderivater
NO20071274L (no) Inhibitorer av hepatitt C virus RNA-avhengig RNA polymerase, og sammensetninger og behandlinger ved anvendelse av samme.
NO20082530L (no) Imidazopyraziner som proteinkinaseinhibitorer
NO20045677L (no) Inhibitorer av JAK- og CDK2-proteinkinaser
NO20073140L (no) Pyrrolopyraziner og pyralopyraziner som er nyttige som inhibitorer av proteinkinaser
ATE494373T2 (de) Verfahren und zusammensetzungen zur verringerung von hcv virusgenommengen in einer zielzelle
NO20082092L (no) Pyrazolopyrimidiner som proteinkinaseinhibitorer
BRPI0511982A (pt) compostos antiviróticos heterocìclicos
NO20062726L (no) Nye pyridazin-3(2H)-on derivater
BRPI0408704A (pt) benzil-piridazinonas como inibidores de transcriptase reversa
EA200602289A1 (ru) Применение иматиниба для лечения нарушений работы печени и вирусных инфекций
WO2021262826A3 (en) 1'-cyano nucleoside analogs and uses thereof
BRPI0408767A (pt) inibidores de transcriptase reversa não-nucleosìdeos i para o tratamento de doenças mediadas pelo hiv
TW200710091A (en) (1,10B-dihydro-2-(aminoalkyl-phenyl)-5H-pyrazolo [1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as HIV viral replication inhibitors
BRPI0414948A (pt) derivados de pirazolo-e-imidazo pirimidina
WO2005041951A3 (en) Rhodanine derivatives for use as antiviral agents
NO20065898L (no) 1-heterocyklyl-1,5-dihydro-pyrido[3,2-b]indol-2-oner
YU62504A (sh) Triciklična 2-pirimidonska jedinjenja korisna kao inhibitori hiv reverzne transkriptoze
WO2005051318A3 (en) Compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases
BR0314860A (pt) Derivados de pirazol