NO20082092L - Pyrazolopyrimidiner som proteinkinaseinhibitorer - Google Patents
Pyrazolopyrimidiner som proteinkinaseinhibitorerInfo
- Publication number
- NO20082092L NO20082092L NO20082092A NO20082092A NO20082092L NO 20082092 L NO20082092 L NO 20082092L NO 20082092 A NO20082092 A NO 20082092A NO 20082092 A NO20082092 A NO 20082092A NO 20082092 L NO20082092 L NO 20082092L
- Authority
- NO
- Norway
- Prior art keywords
- compounds
- pyrazolopyrimidines
- protein kinase
- kinase inhibitors
- protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
I dens mange utførelsesformer tilveiebringer den foreliggende oppfinnelse en ny klasse av aminosubstituerte pyrazolo[1, 5-a]pyrimidinforbindelser representert ved strukturformel (I) som inhibitorer av protein- og/eller sjekkpunktkinaser, fremgangsmåter for fremstilling av slike forbindelser, farmasøytiske preparater som omfatter én eller flere slike forbindelser, fremgangsmåter for fremstilling av farmasøytiske preparater som omfatter én eller flere slike forbindelser, og fremgangsmåter for behandling, forebyggelse, inhibering eller lindring av én eller flere sykdommer forbundet med protein- eller sjekkpunktkinasene, ved å anvende slike forbindelser eller farmasøytiske preparater.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72419705P | 2005-10-06 | 2005-10-06 | |
PCT/US2006/039136 WO2007041712A1 (en) | 2005-10-06 | 2006-10-04 | Pyrazolopyrimidines as protein kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20082092L true NO20082092L (no) | 2008-07-04 |
Family
ID=37560916
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20082092A NO20082092L (no) | 2005-10-06 | 2008-05-05 | Pyrazolopyrimidiner som proteinkinaseinhibitorer |
Country Status (18)
Country | Link |
---|---|
US (1) | US7776865B2 (no) |
EP (1) | EP1931676B1 (no) |
JP (2) | JP5052518B2 (no) |
KR (1) | KR20080063806A (no) |
CN (1) | CN101321760A (no) |
AR (1) | AR056206A1 (no) |
AT (1) | ATE533770T1 (no) |
AU (1) | AU2006299338A1 (no) |
BR (1) | BRPI0617150A2 (no) |
CA (1) | CA2624882C (no) |
EC (1) | ECSP088350A (no) |
IL (1) | IL190598A0 (no) |
NO (1) | NO20082092L (no) |
PE (1) | PE20070543A1 (no) |
RU (1) | RU2008117298A (no) |
TW (1) | TW200745123A (no) |
WO (1) | WO2007041712A1 (no) |
ZA (1) | ZA200802995B (no) |
Families Citing this family (66)
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JP5357763B2 (ja) | 2006-11-06 | 2013-12-04 | トレロ ファーマシューティカルズ, インコーポレイテッド | イミダゾ[1,2−b]ピリダジン誘導体およびピラゾロ[1,5−a]ピリダジン誘導体およびプロテインキナーゼインヒビターとしてのこれらの使用 |
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ATE527264T1 (de) * | 2007-05-09 | 2011-10-15 | Abbott Lab | Kondensierte heterozyklische verbindungen als hemmer von proteinkinasen |
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US8124759B2 (en) | 2007-05-09 | 2012-02-28 | Abbott Laboratories | Inhibitors of protein kinases |
US8618121B2 (en) | 2007-07-02 | 2013-12-31 | Cancer Research Technology Limited | 9H-pyrimido[4,5-B]indoles, 9H-pyrido[4',3':4,5]pyrrolo[2,3-D]pyridines, and 9H 1,3,6,9 tetraaza-fluorenes as CHK1 kinase function inhibitors |
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JP5643105B2 (ja) * | 2007-12-14 | 2014-12-17 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 新規イミダゾ[1,2−a]ピリジン及びイミダゾ[1,2−b]ピリダジン誘導体 |
US8426441B2 (en) * | 2007-12-14 | 2013-04-23 | Roche Palo Alto Llc | Inhibitors of bruton's tyrosine kinase |
JP5638961B2 (ja) | 2008-03-13 | 2014-12-10 | ザ ジェネラル ホスピタル コーポレイション | Bmpシグナル伝達経路のインヒビター |
MX2010012103A (es) * | 2008-05-12 | 2011-04-04 | Amnestix Inc | Compuestos para la inhibicion de la cinasa rho y para mejorar el aprendizaje y la memoria. |
AR071717A1 (es) | 2008-05-13 | 2010-07-07 | Array Biopharma Inc | Pirrolo[2,3-b]piridinas inhibidoras de quinasas chk1 y chk2,composiciones farmaceuticas que las contienen,proceso para prepararlas y uso de las mismas en el tratamiento y prevencion del cancer. |
PA8851101A1 (es) * | 2008-12-16 | 2010-07-27 | Lilly Co Eli | Compuesto amino pirazol |
PE20120534A1 (es) * | 2009-02-13 | 2012-05-10 | Bayer Pharma AG | PIRIMIDINAS FUSIONADAS COMO INHIBIDORES DE Akt |
US8691825B2 (en) | 2009-04-01 | 2014-04-08 | Merck Sharp & Dohme Corp. | Inhibitors of AKT activity |
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EP2473041B1 (en) | 2009-09-04 | 2018-03-07 | Merck Sharp & Dohme Corp. | Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors |
CR20170159A (es) * | 2009-12-01 | 2017-06-26 | Abbvie Inc | Nuevos compuestos tricíclicos |
JP2013530250A (ja) * | 2010-07-13 | 2013-07-25 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 二環式ピリミジン化合物 |
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JP2014517079A (ja) | 2011-06-22 | 2014-07-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | Atrキナーゼ阻害剤として有用な化合物 |
ES2671748T3 (es) | 2011-07-21 | 2018-06-08 | Tolero Pharmaceuticals, Inc. | Inhibidores heterocíclicos de proteína quinasas |
RU2641693C2 (ru) | 2011-11-09 | 2018-01-22 | Кансер Ресёрч Текнолоджи Лимитед | Соединения 5-(пиридин-2-иламино)-пиразин-2-карбонитрила и их терапевтическое применение |
JP6106694B2 (ja) * | 2012-01-10 | 2017-04-05 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | Aktキナーゼ阻害剤としての置換ピラゾロピリミジン類 |
RU2659786C2 (ru) | 2012-05-15 | 2018-07-04 | Кансер Ресёрч Текнолоджи Лимитед | 5-[[4-[[морфолин-2-ил]метиламино]-5-(трифторметил)-2-пиридил]амино]пиразин-2-карбонитрил, его терапевтические применения |
CA2892608C (en) | 2012-12-07 | 2021-10-19 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
JP6437452B2 (ja) | 2013-01-14 | 2018-12-12 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Pimキナーゼ阻害剤として有用な二環式芳香族カルボキサミド化合物 |
MX2015009057A (es) | 2013-01-15 | 2015-10-05 | Incyte Corp | Compuestos de tiazolcarboxamidas y piridinacarboxamida utiles como inhibidores de cinasa pim. |
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US9663519B2 (en) | 2013-03-15 | 2017-05-30 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
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PT3152212T (pt) | 2014-06-05 | 2020-03-13 | Vertex Pharma | Derivados radiomarcados de um composto de 2-amino-6-fluoro-n-[5-fluoro-piridin-3-il]-pirazolo[1,5-a]pirimidin-3-carboxamida útil como inibidor de atr quinase, preparação do dito composto e diferentes formas sólidas do mesmo |
KR20170016498A (ko) | 2014-06-17 | 2017-02-13 | 버텍스 파마슈티칼스 인코포레이티드 | Chk1 및 atr 저해제의 병용물을 사용하는 암의 치료 방법 |
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JP7187308B2 (ja) | 2015-09-30 | 2022-12-12 | バーテックス ファーマシューティカルズ インコーポレイテッド | Dna損傷剤とatr阻害剤との組み合わせを使用する、がんを処置するための方法 |
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US11414431B2 (en) * | 2018-10-15 | 2022-08-16 | Nimbus Lakshmi, Inc. | Substituted pyrazolo[1,5-a]pyrimidines as TYK2 inhibitors |
CN109293630A (zh) * | 2018-11-15 | 2019-02-01 | 山东大学 | 含取代吡唑类化合物及其制备方法与应用 |
CA3127502A1 (en) | 2019-02-12 | 2020-08-20 | Sumitomo Dainippon Pharma Oncology, Inc. | Formulations comprising heterocyclic protein kinase inhibitors |
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DE3130633A1 (de) * | 1981-08-01 | 1983-02-17 | Basf Ag, 6700 Ludwigshafen | 7-amino-azolo(1,5-a)pyrimidine und diese enthaltende fungizide |
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-
2006
- 2006-10-04 US US11/542,921 patent/US7776865B2/en active Active
- 2006-10-04 AR ARP060104364A patent/AR056206A1/es not_active Application Discontinuation
- 2006-10-04 AU AU2006299338A patent/AU2006299338A1/en not_active Abandoned
- 2006-10-04 TW TW095136815A patent/TW200745123A/zh unknown
- 2006-10-04 WO PCT/US2006/039136 patent/WO2007041712A1/en active Application Filing
- 2006-10-04 PE PE2006001206A patent/PE20070543A1/es not_active Application Discontinuation
- 2006-10-04 AT AT06816408T patent/ATE533770T1/de active
- 2006-10-04 KR KR1020087010465A patent/KR20080063806A/ko not_active Application Discontinuation
- 2006-10-04 CA CA2624882A patent/CA2624882C/en not_active Expired - Fee Related
- 2006-10-04 BR BRPI0617150-8A patent/BRPI0617150A2/pt not_active IP Right Cessation
- 2006-10-04 RU RU2008117298/04A patent/RU2008117298A/ru not_active Application Discontinuation
- 2006-10-04 EP EP06816408A patent/EP1931676B1/en active Active
- 2006-10-04 JP JP2008534711A patent/JP5052518B2/ja not_active Expired - Fee Related
- 2006-10-04 CN CNA2006800455049A patent/CN101321760A/zh active Pending
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2008
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- 2008-04-04 EC EC2008008350A patent/ECSP088350A/es unknown
- 2008-04-04 ZA ZA200802995A patent/ZA200802995B/xx unknown
- 2008-05-05 NO NO20082092A patent/NO20082092L/no not_active Application Discontinuation
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2012
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Also Published As
Publication number | Publication date |
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CA2624882A1 (en) | 2007-04-12 |
AR056206A1 (es) | 2007-09-26 |
EP1931676A1 (en) | 2008-06-18 |
CN101321760A (zh) | 2008-12-10 |
BRPI0617150A2 (pt) | 2011-07-12 |
JP5052518B2 (ja) | 2012-10-17 |
RU2008117298A (ru) | 2009-11-20 |
ATE533770T1 (de) | 2011-12-15 |
TW200745123A (en) | 2007-12-16 |
EP1931676B1 (en) | 2011-11-16 |
JP2012082233A (ja) | 2012-04-26 |
IL190598A0 (en) | 2008-11-03 |
US20070083044A1 (en) | 2007-04-12 |
AU2006299338A1 (en) | 2007-04-12 |
US7776865B2 (en) | 2010-08-17 |
JP2009511491A (ja) | 2009-03-19 |
CA2624882C (en) | 2014-05-20 |
PE20070543A1 (es) | 2007-06-14 |
ECSP088350A (es) | 2008-05-30 |
KR20080063806A (ko) | 2008-07-07 |
WO2007041712A1 (en) | 2007-04-12 |
ZA200802995B (en) | 2009-02-25 |
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