NO20082092L - Pyrazolopyrimidiner som proteinkinaseinhibitorer - Google Patents
Pyrazolopyrimidiner som proteinkinaseinhibitorerInfo
- Publication number
- NO20082092L NO20082092L NO20082092A NO20082092A NO20082092L NO 20082092 L NO20082092 L NO 20082092L NO 20082092 A NO20082092 A NO 20082092A NO 20082092 A NO20082092 A NO 20082092A NO 20082092 L NO20082092 L NO 20082092L
- Authority
- NO
- Norway
- Prior art keywords
- compounds
- pyrazolopyrimidines
- protein kinase
- kinase inhibitors
- protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
I dens mange utførelsesformer tilveiebringer den foreliggende oppfinnelse en ny klasse av aminosubstituerte pyrazolo[1, 5-a]pyrimidinforbindelser representert ved strukturformel (I) som inhibitorer av protein- og/eller sjekkpunktkinaser, fremgangsmåter for fremstilling av slike forbindelser, farmasøytiske preparater som omfatter én eller flere slike forbindelser, fremgangsmåter for fremstilling av farmasøytiske preparater som omfatter én eller flere slike forbindelser, og fremgangsmåter for behandling, forebyggelse, inhibering eller lindring av én eller flere sykdommer forbundet med protein- eller sjekkpunktkinasene, ved å anvende slike forbindelser eller farmasøytiske preparater.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72419705P | 2005-10-06 | 2005-10-06 | |
PCT/US2006/039136 WO2007041712A1 (en) | 2005-10-06 | 2006-10-04 | Pyrazolopyrimidines as protein kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20082092L true NO20082092L (no) | 2008-07-04 |
Family
ID=37560916
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20082092A NO20082092L (no) | 2005-10-06 | 2008-05-05 | Pyrazolopyrimidiner som proteinkinaseinhibitorer |
Country Status (18)
Country | Link |
---|---|
US (1) | US7776865B2 (no) |
EP (1) | EP1931676B1 (no) |
JP (2) | JP5052518B2 (no) |
KR (1) | KR20080063806A (no) |
CN (1) | CN101321760A (no) |
AR (1) | AR056206A1 (no) |
AT (1) | ATE533770T1 (no) |
AU (1) | AU2006299338A1 (no) |
BR (1) | BRPI0617150A2 (no) |
CA (1) | CA2624882C (no) |
EC (1) | ECSP088350A (no) |
IL (1) | IL190598A0 (no) |
NO (1) | NO20082092L (no) |
PE (1) | PE20070543A1 (no) |
RU (1) | RU2008117298A (no) |
TW (1) | TW200745123A (no) |
WO (1) | WO2007041712A1 (no) |
ZA (1) | ZA200802995B (no) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1931676B1 (en) * | 2005-10-06 | 2011-11-16 | Schering Corporation | Pyrazolopyrimidines as protein kinase inhibitors |
US20070082900A1 (en) * | 2005-10-06 | 2007-04-12 | Schering Corporation | Methods for inhibiting protein kinases |
AU2007223865A1 (en) * | 2006-03-08 | 2007-09-13 | Novartis Ag | Use of pyrazolo[1,5A]pyrimidin-7-yl amine derivatives in the treatment of neurological disorders |
BRPI0712016A2 (pt) * | 2006-05-22 | 2011-12-27 | Schering Corp | pirazolo[1,5-a]pirimidinas |
EP2089391B1 (en) * | 2006-11-03 | 2013-01-16 | Pharmacyclics, Inc. | Bruton's tyrosine kinase activity probe and method of using |
CA2667487C (en) | 2006-11-06 | 2017-04-04 | Supergen, Inc. | Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors |
CA2686848A1 (en) | 2007-05-08 | 2008-11-20 | Schering Corporation | Methods of treatment using intravenous formulations comprising temozolomide |
EP2150553B1 (en) * | 2007-05-09 | 2011-10-05 | Abbott Laboratories | Condensed heterocyclic compounds as inhibitors of protein kinases |
US8124759B2 (en) | 2007-05-09 | 2012-02-28 | Abbott Laboratories | Inhibitors of protein kinases |
WO2008141140A1 (en) * | 2007-05-09 | 2008-11-20 | Abbott Laboratories | Condensed heterocyclic compounds as inhibitors of protein kinases |
WO2009004329A1 (en) * | 2007-07-02 | 2009-01-08 | Cancer Research Technology Limited | 9h-pyrimido[4,5-b]indoles, 9h-pyrido[4',3':4,5]pyrrolo[2,3-d]pyridines, and 9h-1,3,6,9-tetraaza-fluorenes as chk1 kinase function inhibitors |
US8603998B2 (en) * | 2007-11-07 | 2013-12-10 | Merck Sharp & Dohme Corp. | Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors |
ES2462642T3 (es) * | 2007-12-14 | 2014-05-26 | F. Hoffmann-La Roche Ag | Nuevos derivados de imidazo[1,2-a]piridina e imidazo[1,2-b]piridazina |
US8426441B2 (en) * | 2007-12-14 | 2013-04-23 | Roche Palo Alto Llc | Inhibitors of bruton's tyrosine kinase |
CA2718403A1 (en) | 2008-03-13 | 2009-09-17 | The General Hospital Corporation | Inhibitors of the bmp signaling pathway |
KR20110011669A (ko) * | 2008-05-12 | 2011-02-08 | 엠네스틱스, 인코포레이티드 | Rho 키나제를 억제하고 학습 및 기억력을 개선하기 위한 화합물 |
AR071717A1 (es) | 2008-05-13 | 2010-07-07 | Array Biopharma Inc | Pirrolo[2,3-b]piridinas inhibidoras de quinasas chk1 y chk2,composiciones farmaceuticas que las contienen,proceso para prepararlas y uso de las mismas en el tratamiento y prevencion del cancer. |
PA8851101A1 (es) * | 2008-12-16 | 2010-07-27 | Lilly Co Eli | Compuesto amino pirazol |
AU2010213192A1 (en) * | 2009-02-13 | 2011-08-04 | Bayer Intellectual Property Gmbh | Fused pyrimidines |
WO2010114780A1 (en) | 2009-04-01 | 2010-10-07 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
UA110324C2 (en) * | 2009-07-02 | 2015-12-25 | Genentech Inc | Jak inhibitory compounds based on pyrazolo pyrimidine |
WO2011028638A1 (en) | 2009-09-04 | 2011-03-10 | Schering Corporation | Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors |
BR112012013349B1 (pt) * | 2009-12-01 | 2019-10-22 | Abbott Lab | compostos tricíclicos |
JP2013530250A (ja) * | 2010-07-13 | 2013-07-25 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 二環式ピリミジン化合物 |
CN103384670B (zh) * | 2010-07-28 | 2016-05-25 | 拜耳知识产权有限责任公司 | 取代的咪唑并[1,2-b]哒嗪 |
US9309250B2 (en) | 2011-06-22 | 2016-04-12 | Vertex Pharmaceuticals Incorporated | Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors |
ES2671748T3 (es) | 2011-07-21 | 2018-06-08 | Tolero Pharmaceuticals, Inc. | Inhibidores heterocíclicos de proteína quinasas |
RU2641693C2 (ru) | 2011-11-09 | 2018-01-22 | Кансер Ресёрч Текнолоджи Лимитед | Соединения 5-(пиридин-2-иламино)-пиразин-2-карбонитрила и их терапевтическое применение |
CN104066736B (zh) * | 2012-01-10 | 2017-03-08 | 拜耳知识产权有限责任公司 | 作为akt激酶抑制剂的取代的吡唑并嘧啶 |
PL2855448T3 (pl) | 2012-05-15 | 2017-09-29 | Cancer Research Technology Ltd | 5-[[4-[[morfolino-2-ilo]metyloamino]-5-(trifluorometylo)-2-pirydylo]amino]pirazyno-2-karbonitryl i jego zastosowanie terapeutyczne |
DK2941432T3 (en) | 2012-12-07 | 2018-06-14 | Vertex Pharma | 2-amino-6-fluoro-N- (5-fluoro-4- (4- (4- (oxetan-3-yl) piperazine-1-carbonyl) piperidin-1-yl) pyridine-3-yl) pyrazolo [ 1,5ALPHA] PYRIMIDIN-3-CARBOXAMIDE AS ATR-KINASE INHIBITOR |
WO2014110574A1 (en) | 2013-01-14 | 2014-07-17 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors |
BR122019024759B1 (pt) | 2013-01-15 | 2022-02-08 | Incyte Holdings Corporation | Compostos de tiazolacarboxamidas e piridinacarboxamida, composição compreendendo os mesmos, método de inibição da enzima pim1, pim2, ou pim3, e usos dos referidos compostos |
EP2970311A4 (en) | 2013-03-14 | 2016-11-23 | Brigham & Womens Hospital | BMP INHIBITORS AND METHODS OF USE |
WO2014143241A1 (en) | 2013-03-15 | 2014-09-18 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
JP2016512816A (ja) | 2013-03-15 | 2016-05-09 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Atrキナーゼの阻害剤として有用な化合物 |
JP2016512815A (ja) | 2013-03-15 | 2016-05-09 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Atrキナーゼの阻害剤として有用な縮合ピラゾロピリミジン誘導体 |
TW201536293A (zh) | 2013-07-18 | 2015-10-01 | Taiho Pharmaceutical Co Ltd | 對fgfr抑制劑具耐受性之癌的治療藥 |
PL3023100T3 (pl) * | 2013-07-18 | 2019-07-31 | Taiho Pharmaceutical Co., Ltd. | Lek przeciwnowotworowy do okresowego podawania inhibitora FGFR |
MX2016002367A (es) | 2013-08-23 | 2016-10-28 | Incyte Corp | Compuestos de carboxamida de furo y tienopiridina utiles como inhibidores de cinasas pim. |
US10160760B2 (en) | 2013-12-06 | 2018-12-25 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
SG11201610197XA (en) | 2014-06-05 | 2017-01-27 | Vertex Pharma | Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof |
RS59054B1 (sr) | 2014-06-17 | 2019-08-30 | Vertex Pharma | Postupak za lečenje raka korišćenjem kombinacije chk1 i atr inhibitora |
WO2016010897A1 (en) | 2014-07-14 | 2016-01-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors |
US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
US10513521B2 (en) | 2014-07-15 | 2019-12-24 | The Brigham And Women's Hospital, Inc. | Compositions and methods for inhibiting BMP |
TW201702218A (zh) | 2014-12-12 | 2017-01-16 | 美國杰克森實驗室 | 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法 |
ES2812785T3 (es) | 2015-03-31 | 2021-03-18 | Taiho Pharmaceutical Co Ltd | Cristal de compuesto de alquinilo de benceno 3,5-disustituido |
US9540347B2 (en) | 2015-05-29 | 2017-01-10 | Incyte Corporation | Pyridineamine compounds useful as Pim kinase inhibitors |
AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
US11464774B2 (en) | 2015-09-30 | 2022-10-11 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors |
WO2017059251A1 (en) | 2015-10-02 | 2017-04-06 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
EP3424505A4 (en) | 2016-03-04 | 2019-10-16 | Taiho Pharmaceutical Co., Ltd. | PREPARATION AND COMPOSITION FOR TREATING MALIGNANT TUMORS |
US11883404B2 (en) | 2016-03-04 | 2024-01-30 | Taiho Pharmaceuticals Co., Ltd. | Preparation and composition for treatment of malignant tumors |
RU2769696C2 (ru) * | 2017-05-22 | 2022-04-05 | Ф. Хоффманн-Ля Рош Аг | Терапевтические соединения и композиции и способы их применения |
BR112020001714A2 (pt) | 2017-07-28 | 2020-07-21 | Nimbus Lakshmi, Inc. | inibidores de tyk2 e usos dos mesmos |
US10596161B2 (en) | 2017-12-08 | 2020-03-24 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
FI3769765T3 (fi) | 2018-03-19 | 2024-05-15 | Taiho Pharmaceutical Co Ltd | Natriumalkyylisulfaattia sisältävä farmaseuttinen koostumus |
EP3773560A4 (en) | 2018-04-13 | 2022-01-19 | Sumitomo Dainippon Pharma Oncology, Inc. | PIM KINASE INHIBITORS FOR THE TREATMENT OF MYELOPROLIFERATIVE NEOPLASMS AND CANCER-ASSOCIATED FIBROSIS |
CN108586341B (zh) * | 2018-05-25 | 2020-05-08 | 天津商业大学 | 酰胺类化合物和其药用盐及其制备方法和药物用途 |
WO2020081508A1 (en) * | 2018-10-15 | 2020-04-23 | Nimbus Lakshmi, Inc. | Tyk2 inhibitors and uses thereof |
CN109293630A (zh) * | 2018-11-15 | 2019-02-01 | 山东大学 | 含取代吡唑类化合物及其制备方法与应用 |
AU2020221247A1 (en) | 2019-02-12 | 2021-08-05 | Sumitomo Pharma Oncology, Inc. | Formulations comprising heterocyclic protein kinase inhibitors |
CN112457306A (zh) * | 2019-09-06 | 2021-03-09 | 上海瑛派药业有限公司 | 3,5-二取代吡唑化合物作为激酶抑制剂及其应用 |
CN114957261B (zh) * | 2022-05-17 | 2023-06-23 | 重庆文理学院 | 一种具有抗头颈癌作用的化合物及其制备方法和应用 |
WO2024097653A1 (en) | 2022-10-31 | 2024-05-10 | Sumitomo Pharma America, Inc. | Pim1 inhibitor for treating myeloproliferative neoplasms |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3130633A1 (de) * | 1981-08-01 | 1983-02-17 | Basf Ag, 6700 Ludwigshafen | 7-amino-azolo(1,5-a)pyrimidine und diese enthaltende fungizide |
US5688949A (en) | 1991-04-22 | 1997-11-18 | Otsuka Pharmaceutical Factory, Inc. | Pyrazolo 1,5-A!pyrimidine derivatives and anti-inflammatory agent containing the same |
EP0628559B1 (en) | 1993-06-10 | 2002-04-03 | Beiersdorf-Lilly GmbH | Pyrimidine compounds and their use as pharmaceuticals |
US5571813A (en) | 1993-06-10 | 1996-11-05 | Beiersdorf-Lilly Gmbh | Fused pyrimidine compounds and their use as pharmaceuticals |
AU680370B2 (en) | 1994-06-21 | 1997-07-24 | Otsuka Pharmaceutical Factory, Inc. | Pyrazolo(1,5-a)pyrimidine derivative |
US6313124B1 (en) | 1997-07-23 | 2001-11-06 | Dupont Pharmaceuticals Company | Tetrazine bicyclic compounds |
WO1998054093A1 (en) | 1997-05-30 | 1998-12-03 | Merck & Co., Inc. | Novel angiogenesis inhibitors |
JP2002508324A (ja) | 1997-12-13 | 2002-03-19 | ブリストル−マイヤーズ スクイブ カンパニー | サイクリン依存性キナーゼ阻害剤としてのピラゾロ[3,4−b]ピリジンの使用 |
US6413974B1 (en) | 1998-02-26 | 2002-07-02 | Aventis Pharmaceuticals Inc. | 6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines |
WO2000042042A2 (en) | 1999-01-11 | 2000-07-20 | Princeton University | High affinity inhibitors for target validation and uses thereof |
FR2805160B1 (fr) * | 2000-02-23 | 2002-04-05 | Oreal | Compositions pour la teinture d'oxydation des fibres keratiniques comprenant un n(2-hydroxybenzene)-carbramate ou un n-(2-hydroxybenzene)-uree et une pyrazolopyrimidine, et procedes de teinture |
EP1303513A1 (en) | 2000-07-26 | 2003-04-23 | Bristol-Myers Squibb Company | N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl] carboxamide inhibitors of cyclin dependent kinases |
ZA200301696B (en) | 2000-09-15 | 2004-04-28 | Vertex Pharma | Isoxazoles and their use as inhibitors of erk. |
US7067520B2 (en) * | 2000-11-17 | 2006-06-27 | Ishihara Sangyo Kaisha, Ltd. | Preventive or therapeutic medicines for diabetes containing fused-heterocyclic compounds or their salts |
JP2002212076A (ja) * | 2000-11-17 | 2002-07-31 | Ishihara Sangyo Kaisha Ltd | 縮合複素環化合物またはその塩を含有する糖尿病の予防または治療薬 |
AU2002225096B8 (en) | 2000-12-20 | 2006-07-27 | Ipsen Pharma S.A.S. | Cyclin-dependent kinase (CDK) and glycogen synthase kinase-3 (GSK-3) inhibitors |
CA2483306A1 (en) | 2002-04-23 | 2003-11-06 | Shionogi & Co., Ltd. | Pyrazolo[1,5-a]pyrimidine derivative and nad(p)h oxidase inhibitor containing the same |
DE10223917A1 (de) | 2002-05-29 | 2003-12-11 | Bayer Cropscience Ag | Pyrazolopyrimidine |
MXPA04012245A (es) | 2002-06-04 | 2005-09-30 | Neogenesis Pharmaceuticals Inc | Compuestos de pirazolo[1,5a]pirimidina como agentes antivirales. |
NZ539165A (en) * | 2002-09-04 | 2008-03-28 | Schering Corp | Pyrazolopyrimidines as cyclin-dependent kinase inhibitors |
JP2006522750A (ja) | 2003-04-11 | 2006-10-05 | ノボ ノルディスク アクティーゼルスカブ | 代謝性症候群ならびに関連の疾患および障害を治療するために、11β−ヒドロキシステロイドデヒドロゲナーゼ1型阻害剤および抗高血圧剤を使用する併用療法 |
PE20051089A1 (es) | 2004-01-22 | 2006-01-25 | Novartis Ag | Derivados de pirazolo [1,5-a] pirimidin-7-il-amina como inhibidores de quinasa de proteina |
AU2006206573B9 (en) * | 2005-01-19 | 2011-09-29 | Merck Sharp & Dohme Corp. | Bicyclic pyrimidines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes |
GB0515026D0 (en) * | 2005-07-21 | 2005-08-31 | Novartis Ag | Organic compounds |
EP1931676B1 (en) * | 2005-10-06 | 2011-11-16 | Schering Corporation | Pyrazolopyrimidines as protein kinase inhibitors |
-
2006
- 2006-10-04 EP EP06816408A patent/EP1931676B1/en active Active
- 2006-10-04 AU AU2006299338A patent/AU2006299338A1/en not_active Abandoned
- 2006-10-04 JP JP2008534711A patent/JP5052518B2/ja not_active Expired - Fee Related
- 2006-10-04 CN CNA2006800455049A patent/CN101321760A/zh active Pending
- 2006-10-04 RU RU2008117298/04A patent/RU2008117298A/ru not_active Application Discontinuation
- 2006-10-04 BR BRPI0617150-8A patent/BRPI0617150A2/pt not_active IP Right Cessation
- 2006-10-04 PE PE2006001206A patent/PE20070543A1/es not_active Application Discontinuation
- 2006-10-04 CA CA2624882A patent/CA2624882C/en not_active Expired - Fee Related
- 2006-10-04 US US11/542,921 patent/US7776865B2/en active Active
- 2006-10-04 AT AT06816408T patent/ATE533770T1/de active
- 2006-10-04 KR KR1020087010465A patent/KR20080063806A/ko not_active Application Discontinuation
- 2006-10-04 WO PCT/US2006/039136 patent/WO2007041712A1/en active Application Filing
- 2006-10-04 TW TW095136815A patent/TW200745123A/zh unknown
- 2006-10-04 AR ARP060104364A patent/AR056206A1/es not_active Application Discontinuation
-
2008
- 2008-04-03 IL IL190598A patent/IL190598A0/en unknown
- 2008-04-04 EC EC2008008350A patent/ECSP088350A/es unknown
- 2008-04-04 ZA ZA200802995A patent/ZA200802995B/xx unknown
- 2008-05-05 NO NO20082092A patent/NO20082092L/no not_active Application Discontinuation
-
2012
- 2012-01-27 JP JP2012015794A patent/JP2012082233A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
CA2624882C (en) | 2014-05-20 |
CA2624882A1 (en) | 2007-04-12 |
JP5052518B2 (ja) | 2012-10-17 |
AR056206A1 (es) | 2007-09-26 |
CN101321760A (zh) | 2008-12-10 |
ECSP088350A (es) | 2008-05-30 |
US7776865B2 (en) | 2010-08-17 |
ATE533770T1 (de) | 2011-12-15 |
KR20080063806A (ko) | 2008-07-07 |
EP1931676A1 (en) | 2008-06-18 |
BRPI0617150A2 (pt) | 2011-07-12 |
EP1931676B1 (en) | 2011-11-16 |
JP2009511491A (ja) | 2009-03-19 |
RU2008117298A (ru) | 2009-11-20 |
AU2006299338A1 (en) | 2007-04-12 |
IL190598A0 (en) | 2008-11-03 |
US20070083044A1 (en) | 2007-04-12 |
PE20070543A1 (es) | 2007-06-14 |
ZA200802995B (en) | 2009-02-25 |
TW200745123A (en) | 2007-12-16 |
WO2007041712A1 (en) | 2007-04-12 |
JP2012082233A (ja) | 2012-04-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20082092L (no) | Pyrazolopyrimidiner som proteinkinaseinhibitorer | |
NO20082091L (no) | Nye pyrazolopyrimidiner som syklinavhengige kinaseinhibitorer | |
NO20064046L (no) | Pyrazolpyrimidinderivater som syklinavhengige kinaseinhibitorer | |
NO20082530L (no) | Imidazopyraziner som proteinkinaseinhibitorer | |
NO20071915L (no) | Diaminotriazolforbindelser nyttige som proteinkinaseinhibitorer | |
NO20092668L (no) | 5-cyano-4-(pyrrolo [2,3B] pyridine-3-yl) -pyrimide derivatives useful as protein kinase inhibitors | |
NO20073140L (no) | Pyrrolopyraziner og pyralopyraziner som er nyttige som inhibitorer av proteinkinaser | |
NO20072795L (no) | Pyrazol [1,5-a]pyrimidiner som er nyttige som inhibitorer av proteinkinaser | |
TW200745128A (en) | Pyrazolopyrimidines as protein kinase inhibitors | |
TW200745127A (en) | Pyrazolopyrimidines as protein kinase inhibitors | |
NO20055496L (no) | Pyrazolokinazolinderivater, metoder for deres fremstilling og deres anvendelse som kinaseinhibitorer | |
NO20055092L (no) | Substituerte pyrimidioner | |
WO2007095223A3 (en) | Pyrrolo(3,2-c) pyridines useful as inhibitors of protein kinases | |
WO2007056164A3 (en) | Aminopyrimidines useful as kinase inhibitors | |
NO20045677L (no) | Inhibitorer av JAK- og CDK2-proteinkinaser | |
NO20083918L (no) | Dihydridiazepiner anvendelige som inhibitorer av proteinkinaser | |
WO2007120752A3 (en) | 4, 5-dihydro- [1, 2, 4] triazolo [4, 3-f] pteridines as protein kinase plk1 inhibitors for the treatment of proliferative disorders | |
NO20084435L (no) | C-MET proteinkinaseinhibitorer | |
NO20082093L (no) | Anvendelse av pyrazol [1,5-A]pyrimidinderivater for inhibering av proteinkinaser | |
NO20073628L (no) | Pyridoner som er nyttige som inhibitorer av kinaser | |
WO2002083667A3 (en) | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases | |
WO2007044401A3 (en) | Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors | |
WO2007087283A3 (en) | Thiophene-carboxamides useful as inhibitors of protein kinases | |
WO2008045268A3 (en) | Pyrazolopyrimidines as cyclin dependent kinase inhibitors | |
WO2007022384A3 (en) | Pyrazine kinase inhibitors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |