ZA200802995B - Pyrazolopyrimidines as protein kinase inhibitors - Google Patents
Pyrazolopyrimidines as protein kinase inhibitorsInfo
- Publication number
- ZA200802995B ZA200802995B ZA200802995A ZA200802995A ZA200802995B ZA 200802995 B ZA200802995 B ZA 200802995B ZA 200802995 A ZA200802995 A ZA 200802995A ZA 200802995 A ZA200802995 A ZA 200802995A ZA 200802995 B ZA200802995 B ZA 200802995B
- Authority
- ZA
- South Africa
- Prior art keywords
- pyrazolopyrimidines
- protein kinase
- kinase inhibitors
- inhibitors
- protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72419705P | 2005-10-06 | 2005-10-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200802995B true ZA200802995B (en) | 2009-02-25 |
Family
ID=37560916
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200802995A ZA200802995B (en) | 2005-10-06 | 2008-04-04 | Pyrazolopyrimidines as protein kinase inhibitors |
Country Status (18)
Country | Link |
---|---|
US (1) | US7776865B2 (xx) |
EP (1) | EP1931676B1 (xx) |
JP (2) | JP5052518B2 (xx) |
KR (1) | KR20080063806A (xx) |
CN (1) | CN101321760A (xx) |
AR (1) | AR056206A1 (xx) |
AT (1) | ATE533770T1 (xx) |
AU (1) | AU2006299338A1 (xx) |
BR (1) | BRPI0617150A2 (xx) |
CA (1) | CA2624882C (xx) |
EC (1) | ECSP088350A (xx) |
IL (1) | IL190598A0 (xx) |
NO (1) | NO20082092L (xx) |
PE (1) | PE20070543A1 (xx) |
RU (1) | RU2008117298A (xx) |
TW (1) | TW200745123A (xx) |
WO (1) | WO2007041712A1 (xx) |
ZA (1) | ZA200802995B (xx) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI421078B (zh) * | 2005-10-06 | 2014-01-01 | Merck Sharp & Dohme | 關卡激酶抑制劑及其用途 |
AR056206A1 (es) * | 2005-10-06 | 2007-09-26 | Schering Corp | Pirazolpirimidinas como inhibidores de protein quinasas |
CA2643362A1 (en) * | 2006-03-08 | 2007-09-13 | Novartis Ag | Use of pyrazolo[1,5a]pyrimidin-7-yl amine derivatives in the treatment of neurological disorders |
BRPI0712016A2 (pt) * | 2006-05-22 | 2011-12-27 | Schering Corp | pirazolo[1,5-a]pirimidinas |
EP2089391B1 (en) * | 2006-11-03 | 2013-01-16 | Pharmacyclics, Inc. | Bruton's tyrosine kinase activity probe and method of using |
JP5357763B2 (ja) | 2006-11-06 | 2013-12-04 | トレロ ファーマシューティカルズ, インコーポレイテッド | イミダゾ[1,2−b]ピリダジン誘導体およびピラゾロ[1,5−a]ピリダジン誘導体およびプロテインキナーゼインヒビターとしてのこれらの使用 |
TW200845962A (en) | 2007-05-08 | 2008-12-01 | Schering Corp | Methods of treatment using intravenous formulations comprising temozolomide |
US8124759B2 (en) | 2007-05-09 | 2012-02-28 | Abbott Laboratories | Inhibitors of protein kinases |
WO2008141140A1 (en) * | 2007-05-09 | 2008-11-20 | Abbott Laboratories | Condensed heterocyclic compounds as inhibitors of protein kinases |
MX2009012079A (es) * | 2007-05-09 | 2009-11-19 | Abbott Lab | Compuestos heterociclicos condensados como inhibidores de proteina cinasas. |
US8618121B2 (en) | 2007-07-02 | 2013-12-31 | Cancer Research Technology Limited | 9H-pyrimido[4,5-B]indoles, 9H-pyrido[4',3':4,5]pyrrolo[2,3-D]pyridines, and 9H 1,3,6,9 tetraaza-fluorenes as CHK1 kinase function inhibitors |
AR069198A1 (es) * | 2007-11-07 | 2010-01-06 | Schering Corp | Derivados de ribosil pirimidinas moduladores de quinasas de control chk1,y composiciones farmaceuticas que los comprenden utiles en el tratamiento del cancer. |
US8426441B2 (en) * | 2007-12-14 | 2013-04-23 | Roche Palo Alto Llc | Inhibitors of bruton's tyrosine kinase |
EP2229390B1 (en) * | 2007-12-14 | 2014-04-09 | F. Hoffmann-La Roche AG | Novel imidazoý1,2-a¨pyridine and imidazoý1,2-b¨pyridazine derivatives |
WO2009114180A1 (en) * | 2008-03-13 | 2009-09-17 | The General Hospital Corporation | Inhibitors of the bmp signaling pathway |
KR20110014183A (ko) * | 2008-05-12 | 2011-02-10 | 엠네스틱스, 인코포레이티드 | 학습 및 기억을 개선시키기 위한 화합물 |
AR071717A1 (es) | 2008-05-13 | 2010-07-07 | Array Biopharma Inc | Pirrolo[2,3-b]piridinas inhibidoras de quinasas chk1 y chk2,composiciones farmaceuticas que las contienen,proceso para prepararlas y uso de las mismas en el tratamiento y prevencion del cancer. |
PA8851101A1 (es) * | 2008-12-16 | 2010-07-27 | Lilly Co Eli | Compuesto amino pirazol |
KR20110114663A (ko) * | 2009-02-13 | 2011-10-19 | 바이엘 파마 악티엔게젤샤프트 | 융합된 피리미딘 |
EP2413932A4 (en) * | 2009-04-01 | 2012-09-19 | Merck Sharp & Dohme | INHIBITORS OF AKT ACTIVITY |
UA110324C2 (xx) * | 2009-07-02 | 2015-12-25 | Genentech Inc | Інгібуючі jak сполуки на основі піразолопіримідину |
EP2473041B1 (en) | 2009-09-04 | 2018-03-07 | Merck Sharp & Dohme Corp. | Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors |
TWI500620B (zh) * | 2009-12-01 | 2015-09-21 | Abbvie Inc | 新穎三環化合物 |
US20130184273A1 (en) * | 2010-07-13 | 2013-07-18 | Bayer Intellectual Property Gmbh | Bicyclic pyrimidines |
JP5926727B2 (ja) * | 2010-07-28 | 2016-05-25 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | 置換イミダゾ[1,2−b]ピリダジン |
US9309250B2 (en) | 2011-06-22 | 2016-04-12 | Vertex Pharmaceuticals Incorporated | Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors |
JP6105578B2 (ja) | 2011-07-21 | 2017-03-29 | トレロ ファーマシューティカルズ, インコーポレイテッド | 複素環式プロテインキナーゼ阻害剤 |
ES2709003T3 (es) | 2011-11-09 | 2019-04-12 | Cancer Research Tech Ltd | Compuestos de 5-(piridin-2-il-amino)-pirazina-2-carbonitrilo y su uso terapéutico |
CA2860724A1 (en) * | 2012-01-10 | 2013-07-18 | Bayer Intellectual Property Gmbh | Substituted pyrazolopyrimidines as akt kinase inhibitors |
KR102635954B1 (ko) | 2012-05-15 | 2024-02-13 | 캔써 리서치 테크놀로지 리미티드 | 5-[[4-[[모르폴린-2-일]메틸아미노]-5-(트리플루오로메틸)-2-피리딜]아미노]피라진-2-카보니트릴 및 그의 치료적 용도 |
EP3808749B1 (en) | 2012-12-07 | 2023-03-08 | Vertex Pharmaceuticals Incorporated | Pyrazolo[1,5-a]pyrimidines useful as inhibitors of atr kinase for the treatment of cancer diseases |
JP6437452B2 (ja) | 2013-01-14 | 2018-12-12 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Pimキナーゼ阻害剤として有用な二環式芳香族カルボキサミド化合物 |
HUE050215T2 (hu) | 2013-01-15 | 2020-11-30 | Incyte Holdings Corp | Pim kináz inhibitorokként hasznos tiazolkarboxamid és piridinkarboxamid vegyületek |
EP2970311A4 (en) | 2013-03-14 | 2016-11-23 | Brigham & Womens Hospital | BMP INHIBITORS AND METHODS OF USE |
US9663519B2 (en) | 2013-03-15 | 2017-05-30 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
US8969360B2 (en) | 2013-03-15 | 2015-03-03 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
WO2014143241A1 (en) | 2013-03-15 | 2014-09-18 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
ES2819398T3 (es) | 2013-07-18 | 2021-04-15 | Taiho Pharmaceutical Co Ltd | Agente terapéutico para el cáncer resistente al inhibidor de FGFR |
DK3023100T3 (da) * | 2013-07-18 | 2019-05-27 | Taiho Pharmaceutical Co Ltd | Antitumorlægemiddel til intermitterende administration af fgfr-hæmmer |
JP2016528298A (ja) | 2013-08-23 | 2016-09-15 | インサイト・コーポレイションIncyte Corporation | Pimキナーゼ阻害剤として有用なフロピリジン及びチエノピリジンカルボキシアミド化合物 |
HUE046727T2 (hu) | 2013-12-06 | 2020-03-30 | Vertex Pharma | Az ATR-kináz inhibitoraként használható vegyület, 2-amino-6-fluoro-N-[5-fluoro-piridin-3-IL]-pirazolo-[1,5-A]-pirimidin-3-karboxamid, ennek elõállítása, különbözõ szilárd formái és ezek radioaktív nyomjelzett származékai |
EP3152212B9 (en) | 2014-06-05 | 2020-05-27 | Vertex Pharmaceuticals Inc. | Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof |
JP6936007B2 (ja) | 2014-06-17 | 2021-09-15 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Chk1阻害剤とatr阻害剤との組み合わせを使用してがんを処置する方法 |
US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
US10513521B2 (en) | 2014-07-15 | 2019-12-24 | The Brigham And Women's Hospital, Inc. | Compositions and methods for inhibiting BMP |
TW201702218A (zh) | 2014-12-12 | 2017-01-16 | 美國杰克森實驗室 | 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法 |
DK3279202T3 (da) | 2015-03-31 | 2020-08-17 | Taiho Pharmaceutical Co Ltd | Krystal af 3,5-disubstitueret benzenalkynylforbindelse |
WO2016196244A1 (en) | 2015-05-29 | 2016-12-08 | Incyte Corporation | Pyridineamine compounds useful as pim kinase inhibitors |
AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
AU2016331955B2 (en) | 2015-09-30 | 2022-07-21 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors |
TW201718546A (zh) | 2015-10-02 | 2017-06-01 | 英塞特公司 | 適用作pim激酶抑制劑之雜環化合物 |
US11883404B2 (en) | 2016-03-04 | 2024-01-30 | Taiho Pharmaceuticals Co., Ltd. | Preparation and composition for treatment of malignant tumors |
EP3424505A4 (en) | 2016-03-04 | 2019-10-16 | Taiho Pharmaceutical Co., Ltd. | PREPARATION AND COMPOSITION FOR TREATING MALIGNANT TUMORS |
EP3630766A1 (en) * | 2017-05-22 | 2020-04-08 | H. Hoffnabb-La Roche Ag | Therapeutic compounds and compositions, and methods of use thereof |
JP7216705B2 (ja) | 2017-07-28 | 2023-02-02 | ニンバス ラクシュミ, インコーポレイテッド | Tyk2阻害剤およびその使用方法 |
AR113922A1 (es) | 2017-12-08 | 2020-07-01 | Incyte Corp | Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas |
BR112020018697A2 (pt) | 2018-03-19 | 2020-12-29 | Taiho Pharmaceutical Co., Ltd. | Composição farmacêutica incluindo alquilsulfato de sódio |
US20210113562A1 (en) | 2018-04-13 | 2021-04-22 | Sumitomo Dainippon Pharma Oncology, Inc. | Pim kinase inhibitors for treatment of myeloproliferative neoplasms and fibrosis associated with cancer |
CN108586341B (zh) * | 2018-05-25 | 2020-05-08 | 天津商业大学 | 酰胺类化合物和其药用盐及其制备方法和药物用途 |
AU2019360941A1 (en) * | 2018-10-15 | 2021-04-29 | Takeda Pharmaceutical Company Limited | TYK2 inhibitors and uses thereof |
CN109293630A (zh) * | 2018-11-15 | 2019-02-01 | 山东大学 | 含取代吡唑类化合物及其制备方法与应用 |
WO2020167990A1 (en) | 2019-02-12 | 2020-08-20 | Tolero Pharmaceuticals, Inc. | Formulations comprising heterocyclic protein kinase inhibitors |
CN112457306A (zh) * | 2019-09-06 | 2021-03-09 | 上海瑛派药业有限公司 | 3,5-二取代吡唑化合物作为激酶抑制剂及其应用 |
CN114957261B (zh) * | 2022-05-17 | 2023-06-23 | 重庆文理学院 | 一种具有抗头颈癌作用的化合物及其制备方法和应用 |
WO2024097653A1 (en) | 2022-10-31 | 2024-05-10 | Sumitomo Pharma America, Inc. | Pim1 inhibitor for treating myeloproliferative neoplasms |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3130633A1 (de) * | 1981-08-01 | 1983-02-17 | Basf Ag, 6700 Ludwigshafen | 7-amino-azolo(1,5-a)pyrimidine und diese enthaltende fungizide |
ES2126573T3 (es) | 1991-04-22 | 1999-04-01 | Otsuka Pharma Co Ltd | Derivado de pirazol (1,5-a)pirimidina y agente antiinflamatorio que contiene este derivado. |
US5571813A (en) | 1993-06-10 | 1996-11-05 | Beiersdorf-Lilly Gmbh | Fused pyrimidine compounds and their use as pharmaceuticals |
EP0628559B1 (en) | 1993-06-10 | 2002-04-03 | Beiersdorf-Lilly GmbH | Pyrimidine compounds and their use as pharmaceuticals |
ATE208776T1 (de) | 1994-06-21 | 2001-11-15 | Otsuka Pharma Co Ltd | Pyrazolo(1,5-a) pyrimidin-derivate |
US6313124B1 (en) | 1997-07-23 | 2001-11-06 | Dupont Pharmaceuticals Company | Tetrazine bicyclic compounds |
AU734009B2 (en) | 1997-05-30 | 2001-05-31 | Merck & Co., Inc. | Novel angiogenesis inhibitors |
ATE355841T1 (de) | 1997-12-13 | 2007-03-15 | Bristol Myers Squibb Co | Verwendung von pyrazolo ( 3,4-b) pyridin als cyclin-abhängige kinase hemmer |
US6413974B1 (en) | 1998-02-26 | 2002-07-02 | Aventis Pharmaceuticals Inc. | 6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines |
DE60004781T2 (de) | 1999-01-11 | 2004-07-08 | Princeton University | Kinase-inhibitoren mit hoher affinität zur ziel detektion und ihre verwendung |
FR2805160B1 (fr) * | 2000-02-23 | 2002-04-05 | Oreal | Compositions pour la teinture d'oxydation des fibres keratiniques comprenant un n(2-hydroxybenzene)-carbramate ou un n-(2-hydroxybenzene)-uree et une pyrazolopyrimidine, et procedes de teinture |
EE200300041A (et) | 2000-07-26 | 2005-04-15 | Bristol-Myers Squibb Company | Tsükliin-sõltuvate kinaaside N-[5-[[[5-alküül-2-oksasolüül]metüül]tio]-2-tiasolüül]karboksamiidinhibiitorid |
NZ525016A (en) | 2000-09-15 | 2004-10-29 | Vertex Pharma | Isoxazoles and their use as inhibitors of ERK |
JP2002212076A (ja) * | 2000-11-17 | 2002-07-31 | Ishihara Sangyo Kaisha Ltd | 縮合複素環化合物またはその塩を含有する糖尿病の予防または治療薬 |
US7067520B2 (en) * | 2000-11-17 | 2006-06-27 | Ishihara Sangyo Kaisha, Ltd. | Preventive or therapeutic medicines for diabetes containing fused-heterocyclic compounds or their salts |
CA2432417A1 (fr) | 2000-12-20 | 2002-06-27 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R .A.S.) | Inhibiteurs de kinases dependantes des cylines (cdk) et de la glycogene synthase kinase-3 (gsk-3) |
AU2003227437A1 (en) | 2002-04-23 | 2003-11-10 | Shionogi And Co., Ltd. | PYRAZOLO(1,5-a)PYRIMIDINE DERIVATIVE AND NAD(P)H OXIDASE INHIBITOR CONTAINING THE SAME |
DE10223917A1 (de) | 2002-05-29 | 2003-12-11 | Bayer Cropscience Ag | Pyrazolopyrimidine |
MXPA04012245A (es) | 2002-06-04 | 2005-09-30 | Neogenesis Pharmaceuticals Inc | Compuestos de pirazolo[1,5a]pirimidina como agentes antivirales. |
JP4881558B2 (ja) * | 2002-09-04 | 2012-02-22 | シェーリング コーポレイション | サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン |
WO2004089416A2 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | Combination of an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent |
PE20051089A1 (es) | 2004-01-22 | 2006-01-25 | Novartis Ag | Derivados de pirazolo [1,5-a] pirimidin-7-il-amina como inhibidores de quinasa de proteina |
WO2006078676A2 (en) * | 2005-01-19 | 2006-07-27 | Merck & Co., Inc. | Bicyclic pyrimidines as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
GB0515026D0 (en) * | 2005-07-21 | 2005-08-31 | Novartis Ag | Organic compounds |
AR056206A1 (es) * | 2005-10-06 | 2007-09-26 | Schering Corp | Pirazolpirimidinas como inhibidores de protein quinasas |
-
2006
- 2006-10-04 AR ARP060104364A patent/AR056206A1/es not_active Application Discontinuation
- 2006-10-04 TW TW095136815A patent/TW200745123A/zh unknown
- 2006-10-04 PE PE2006001206A patent/PE20070543A1/es not_active Application Discontinuation
- 2006-10-04 WO PCT/US2006/039136 patent/WO2007041712A1/en active Application Filing
- 2006-10-04 CN CNA2006800455049A patent/CN101321760A/zh active Pending
- 2006-10-04 RU RU2008117298/04A patent/RU2008117298A/ru not_active Application Discontinuation
- 2006-10-04 KR KR1020087010465A patent/KR20080063806A/ko not_active Application Discontinuation
- 2006-10-04 BR BRPI0617150-8A patent/BRPI0617150A2/pt not_active IP Right Cessation
- 2006-10-04 JP JP2008534711A patent/JP5052518B2/ja not_active Expired - Fee Related
- 2006-10-04 AT AT06816408T patent/ATE533770T1/de active
- 2006-10-04 CA CA2624882A patent/CA2624882C/en not_active Expired - Fee Related
- 2006-10-04 EP EP06816408A patent/EP1931676B1/en active Active
- 2006-10-04 US US11/542,921 patent/US7776865B2/en active Active
- 2006-10-04 AU AU2006299338A patent/AU2006299338A1/en not_active Abandoned
-
2008
- 2008-04-03 IL IL190598A patent/IL190598A0/en unknown
- 2008-04-04 ZA ZA200802995A patent/ZA200802995B/xx unknown
- 2008-04-04 EC EC2008008350A patent/ECSP088350A/es unknown
- 2008-05-05 NO NO20082092A patent/NO20082092L/no not_active Application Discontinuation
-
2012
- 2012-01-27 JP JP2012015794A patent/JP2012082233A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
TW200745123A (en) | 2007-12-16 |
EP1931676A1 (en) | 2008-06-18 |
CN101321760A (zh) | 2008-12-10 |
CA2624882C (en) | 2014-05-20 |
IL190598A0 (en) | 2008-11-03 |
NO20082092L (no) | 2008-07-04 |
WO2007041712A1 (en) | 2007-04-12 |
US20070083044A1 (en) | 2007-04-12 |
ATE533770T1 (de) | 2011-12-15 |
AR056206A1 (es) | 2007-09-26 |
KR20080063806A (ko) | 2008-07-07 |
PE20070543A1 (es) | 2007-06-14 |
EP1931676B1 (en) | 2011-11-16 |
JP2009511491A (ja) | 2009-03-19 |
US7776865B2 (en) | 2010-08-17 |
BRPI0617150A2 (pt) | 2011-07-12 |
AU2006299338A1 (en) | 2007-04-12 |
CA2624882A1 (en) | 2007-04-12 |
JP5052518B2 (ja) | 2012-10-17 |
RU2008117298A (ru) | 2009-11-20 |
ECSP088350A (es) | 2008-05-30 |
JP2012082233A (ja) | 2012-04-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL190598A0 (en) | Pyrazolopyrimidines as protein kinase inhibitors | |
ZA200803894B (en) | Imidazopyrazines as protein kinase inhibitors | |
TWI372625B (en) | Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors | |
ZA200709269B (en) | Protein kinase inhibitors | |
PL1874770T3 (pl) | Fenyloacetamidy odpowiednie jako inhibitory kinaz białkowych | |
HK1114380A1 (en) | Pyrrolopyrazoles as kinase inhibitors | |
IL180806A0 (en) | Imidazopyrazine as tyrosine kinase inhibitors | |
IL177278A0 (en) | Pyrazolotriazines as kinase inhibitors | |
SI1893612T1 (sl) | Pirolo b piridin derivati kot protein kinazni inhibitorji | |
DK1973910T3 (da) | Pyrrolo[3,2-c]pyridin-4-on-2-indolinon-proteinkinaseinhibitorer | |
IL190078A0 (en) | Kinase inhibitors | |
EP1761268A4 (en) | KINASE INHIBITORS BASED ON PYRROLOTRIAZINE | |
ZA200900109B (en) | Pyrrolotriazine kinase inhibitors | |
PL1891066T3 (pl) | Związki i kompozycje jako inhibitory kinazy białkowej | |
EP1841431A4 (en) | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | |
EP1773837A4 (en) | Pyrrolotriazine KINASE INHIBITORS | |
HK1163677A1 (zh) | 可用作激酶抑制劑的吡唑基氨基吡啶衍生物 | |
ZA200710343B (en) | Bicyclic derivatives as p38 kinase inhibitors | |
SI1943243T1 (sl) | Inhibotorji kinaz | |
EP1912639A4 (en) | Thiazolopyrimidine KINASE INHIBITORS | |
IL188027A0 (en) | Bicyclic derivatives as p38 kinase inhibitors | |
PL1896422T3 (pl) | Inhibitory kinazy tyrozynowej | |
IL194491A0 (en) | Thiazolyldihydroindazole derivatives as protein kinase inhibitors | |
EP1951252A4 (en) | INHIBITORS OF TYROSINE KINASES | |
ZA200810573B (en) | Substituted 3-cyanopyridines as protein kinase inhibitors |