ATE208776T1 - Pyrazolo(1,5-a) pyrimidin-derivate - Google Patents

Pyrazolo(1,5-a) pyrimidin-derivate

Info

Publication number
ATE208776T1
ATE208776T1 AT95920260T AT95920260T ATE208776T1 AT E208776 T1 ATE208776 T1 AT E208776T1 AT 95920260 T AT95920260 T AT 95920260T AT 95920260 T AT95920260 T AT 95920260T AT E208776 T1 ATE208776 T1 AT E208776T1
Authority
AT
Austria
Prior art keywords
halogen
alkyl
phenyl
substituted
hydrogen
Prior art date
Application number
AT95920260T
Other languages
English (en)
Inventor
Yasuo Shoji
Makoto Inoue
Takashi Okamura
Kinji Hashimoto
Masayuki Ohara
Tsuneo Yasuda
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Application granted granted Critical
Publication of ATE208776T1 publication Critical patent/ATE208776T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT95920260T 1994-06-21 1995-06-05 Pyrazolo(1,5-a) pyrimidin-derivate ATE208776T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP13863594 1994-06-21
JP5399795 1995-03-14
PCT/JP1995/001104 WO1995035298A1 (fr) 1994-06-21 1995-06-05 DERIVE DE PYRAZOLO[1,5-a]PYRIMIDINE

Publications (1)

Publication Number Publication Date
ATE208776T1 true ATE208776T1 (de) 2001-11-15

Family

ID=26394734

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95920260T ATE208776T1 (de) 1994-06-21 1995-06-05 Pyrazolo(1,5-a) pyrimidin-derivate

Country Status (13)

Country Link
US (1) US5707997A (de)
EP (1) EP0714898B1 (de)
KR (1) KR100315837B1 (de)
CN (1) CN1046730C (de)
AT (1) ATE208776T1 (de)
AU (1) AU680370B2 (de)
CA (1) CA2169719C (de)
DE (1) DE69523864T2 (de)
DK (1) DK0714898T3 (de)
ES (1) ES2164153T3 (de)
PT (1) PT714898E (de)
TW (1) TW307767B (de)
WO (1) WO1995035298A1 (de)

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US6664261B2 (en) 1996-02-07 2003-12-16 Neurocrine Biosciences, Inc. Pyrazolopyrimidines as CRF receptor antagonists
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US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
US6124289A (en) * 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
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EA006626B1 (ru) * 1996-07-24 2006-02-24 Дюпон Фармасьютикалз Компани Азолопиримидины, фармацевтическая композиция и способ лечения
EP1019501A1 (de) * 1997-03-14 2000-07-19 Otsuka Pharmaceutical Co., Ltd. Pyrimidinderivat
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WO2000059908A2 (en) 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolopyrimidines as crf antagonists
AU4331500A (en) 1999-04-06 2000-10-23 Du Pont Pharmaceuticals Company Pyrazolotriazines as crf antagonists
US20020061897A1 (en) 2000-03-30 2002-05-23 Elliott Richard L. Neuropeptide Y antagonists
US6630476B2 (en) 2000-07-07 2003-10-07 Bristol-Myers Squibb Pharma Company Pyrrolo [3,4-d] pyrimidines as corticotropin releasing factor (CRF) antagonists
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
ATE541847T1 (de) * 2001-11-01 2012-02-15 Icagen Inc Pyrazolopyrimidine als natriumkanalblocker
US20040028716A1 (en) * 2002-06-14 2004-02-12 Marks Andrew R. Use of Y-27632 as an agent to prevent restenosis after coronary artery angioplasty/stent implantation
US7119200B2 (en) * 2002-09-04 2006-10-10 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
ES2285164T3 (es) * 2002-09-04 2007-11-16 Schering Corporation Pirazolopirimidinas como inhibidores de quinasas dependientes de ciclina.
US8580782B2 (en) 2002-09-04 2013-11-12 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
EP1534712B1 (de) * 2002-09-04 2007-05-16 Schering Corporation Pyrazolo[1,5-a]pyrimidine als hemmstoffe cyclin-abhängiger kinasen
US8673924B2 (en) 2002-09-04 2014-03-18 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
WO2004022560A1 (en) 2002-09-04 2004-03-18 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7205308B2 (en) * 2002-09-04 2007-04-17 Schering Corporation Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
US7161003B1 (en) * 2002-09-04 2007-01-09 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
TW200412966A (en) 2002-09-04 2004-08-01 Schering Corp Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7196078B2 (en) * 2002-09-04 2007-03-27 Schering Corpoartion Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
PL224879B1 (pl) 2002-09-04 2017-02-28 Pharmacopeia Drug Discovery Inc Pirazolo [1,5-a] pirymidynowy związek, jego zastosowanie do wytwarzania leku oraz zawierająca go farmaceutyczna kompozycja
US6949895B2 (en) * 2003-09-03 2005-09-27 Axcelis Technologies, Inc. Unipolar electrostatic quadrupole lens and switching methods for charged beam transport
AR049769A1 (es) * 2004-01-22 2006-09-06 Novartis Ag Derivados de pirazolo(1,5-a)pirimidin 7-il-amina para utilizarse en el tratamiento de enfermedades dependientes de la quinasa de proteina
WO2006040645A1 (en) * 2004-10-11 2006-04-20 Ranbaxy Laboratories Limited N-(3,5-dichloropyridin-4-yl)-2,4,5-alkoxy and 2,3,4-alkoxy benzamide derivatives as pde-iv (phophodiesterase type-iv) inhibitors for the treatment of inflammatory diseases such as asthma
GB0519957D0 (en) 2005-09-30 2005-11-09 Sb Pharmco Inc Chemical compound
TW200639163A (en) * 2005-02-04 2006-11-16 Genentech Inc RAF inhibitor compounds and methods
CN101128466A (zh) * 2005-03-01 2008-02-20 巴斯福股份公司 5,6-二烷基-7-氨基唑并嘧啶、其制备方法及其在防治病原性真菌中的用途以及包含这些化合物的组合物
JP2008531656A (ja) * 2005-03-02 2008-08-14 ビーエーエスエフ ソシエタス・ヨーロピア ２−置換７−アミノアゾロピリミジン、それの製造方法および病原性菌類防除におけるそれの使用、ならびにその化合物を含む薬剤
ES2349476T3 (es) * 2005-09-09 2011-01-03 Schering Corporation Nuevos derivados de 4-ciano, 4-amino y 4-aminometilo de compuestos de pirazolo[1,5-a]piridinas, pirazolo[1,5-c]pirimidinas y 2h-indazol y derivados de 5-ciano, 5-amino y 5-aminometilo de compuestos de imidazo[1,2-a]piridinas e imidazo[1,5-a]pirazinas, como inhibidores de cinasa dependiente de ciclina.
US7776865B2 (en) 2005-10-06 2010-08-17 Schering Corporation Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
CA2670636A1 (en) * 2006-11-27 2008-06-05 H. Lundbeck A/S Heteroaryl amide derivatives
MX2009010523A (es) * 2007-04-10 2009-12-15 Lundbeck & Co As H Análogos de amidas heteroarílicas como antagonistas de p2x7.
WO2010116176A1 (en) 2009-04-09 2010-10-14 Astrazeneca Ab Pyrazolo [4, 5-e] pyrimidine derivative and its use to treat diabetes and obesity
KR20140077963A (ko) 2011-10-20 2014-06-24 글락소스미스클라인 엘엘씨 시르투인 조절제로서의 치환된 비시클릭 아자-헤테로사이클 및 유사체
AU2012325916A1 (en) * 2011-10-20 2014-05-01 Glaxosmithkline Llc Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators
AR085073A1 (es) * 2012-01-11 2013-09-11 Richmond Sa Com Ind Y Financiera Lab Compuestos con actividad antibacteriana, un procedimiento para su obtencion y composiciones farmaceuticas que los comprenden
US9969687B2 (en) 2013-12-23 2018-05-15 Norgine B.V. Compounds useful as CCR9 modulators
WO2015097122A1 (en) 2013-12-23 2015-07-02 Norgine B.V. Benzene sulfonamides as ccr9 inhibitors
WO2015143652A1 (en) * 2014-03-26 2015-10-01 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
US11155560B2 (en) 2018-10-30 2021-10-26 Kronos Bio, Inc. Substituted pyrazolo[1,5-a]pyrimidines for modulating CDK9 activity

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
US3925385A (en) * 1972-04-20 1975-12-09 Icn Pharmaceuticals 6-Carbethoxy-3,7-disubstitutedpyrazolo{8 1,5a{9 pyrimidines
BE792533A (fr) * 1971-12-09 1973-06-08 Int Chem & Nuclear Corp Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation
JPS6157587A (ja) * 1984-08-29 1986-03-24 Shionogi & Co Ltd 縮合複素環誘導体および抗潰瘍剤
US4950585A (en) * 1987-08-18 1990-08-21 Konica Corporation Coupler for photographic use
JP2585462B2 (ja) * 1989-10-25 1997-02-26 株式会社大塚製薬工場 ピラゾロ［１，５―ａ］ピリミジン誘導体
ATE174917T1 (de) * 1991-04-22 1999-01-15 Otsuka Pharma Co Ltd Pyrazolo(1,5-a>pyrimidinderivate und sie enthaltende antiinflammatorische mittel
KR0133372B1 (ko) * 1991-09-06 1998-04-23 고야 다다시 4-아미노(알킬)시클로헥산-1-카르복사미드 화합물 및 그 용도
US5571813A (en) * 1993-06-10 1996-11-05 Beiersdorf-Lilly Gmbh Fused pyrimidine compounds and their use as pharmaceuticals

Also Published As

Publication number Publication date
US5707997A (en) 1998-01-13
EP0714898A4 (de) 1997-04-02
ES2164153T3 (es) 2002-02-16
WO1995035298A1 (fr) 1995-12-28
DK0714898T3 (da) 2002-03-18
PT714898E (pt) 2002-04-29
AU2576595A (en) 1996-01-15
CA2169719A1 (en) 1995-12-28
DE69523864D1 (de) 2001-12-20
DE69523864T2 (de) 2002-06-13
CN1046730C (zh) 1999-11-24
TW307767B (de) 1997-06-11
AU680370B2 (en) 1997-07-24
CA2169719C (en) 2002-04-16
KR960703919A (ko) 1996-08-31
EP0714898B1 (de) 2001-11-14
EP0714898A1 (de) 1996-06-05
KR100315837B1 (ko) 2002-02-28
CN1131948A (zh) 1996-09-25

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee