ES2169220T3 - Derivados de vitamina d3 con sustituyentes en la posicion 2. - Google Patents

Derivados de vitamina d3 con sustituyentes en la posicion 2.

Info

Publication number
ES2169220T3
ES2169220T3 ES96900724T ES96900724T ES2169220T3 ES 2169220 T3 ES2169220 T3 ES 2169220T3 ES 96900724 T ES96900724 T ES 96900724T ES 96900724 T ES96900724 T ES 96900724T ES 2169220 T3 ES2169220 T3 ES 2169220T3
Authority
ES
Spain
Prior art keywords
group
carbon atoms
substitutes
vitamin
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96900724T
Other languages
English (en)
Inventor
Yoshiyuki Ono
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2169220T3 publication Critical patent/ES2169220T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE DESCRIBE UN COMPUESTO REPRESENTADO POR LA FORMULA GENERAL (I): DONDE R{SUB,1} Y R{SUB,2}, QUE PUEDEN SER IGUALES O DIFERENTES, REPRESENTAN CADA UNO UN GRUPO ALQUILO CON (1) A (4) ATOMOS DE CARBONO Y R{SUB,3} REPRESENTA UN GRUPO ALCOXI CON (1) A (7) ATOMOS DE CARBONO QUE PUEDE SER SUSTITUIDO POR UNO O MAS SUSTITUYENTES SELECCIONADOS DE UN GRUPO HIDROXILO, UN ATOMO DE HALOGENO, UN GRUPO CIANO, UN GRUPO ALCOXI CON (1) A (4) ATOMOS DE CARBONO, UN GRUPO AMINO Y UN GRUPO ACILAMINO CON LA CONDICION DE QUE R{SUB,1} Y R{SUB,2} NO SEAN SIMULTANEAMENTE UN GRUPO METILO. EL COMPUESTO DE ESTA INVENCION ES UTIL COMO MEDICAMENTO.
ES96900724T 1995-01-23 1996-01-22 Derivados de vitamina d3 con sustituyentes en la posicion 2. Expired - Lifetime ES2169220T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4224595 1995-01-23

Publications (1)

Publication Number Publication Date
ES2169220T3 true ES2169220T3 (es) 2002-07-01

Family

ID=12630650

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96900724T Expired - Lifetime ES2169220T3 (es) 1995-01-23 1996-01-22 Derivados de vitamina d3 con sustituyentes en la posicion 2.

Country Status (10)

Country Link
US (1) US5883271A (es)
EP (1) EP0806413B1 (es)
AT (1) ATE210642T1 (es)
AU (1) AU4459296A (es)
CA (1) CA2210106A1 (es)
DE (1) DE69617909T2 (es)
DK (1) DK0806413T3 (es)
ES (1) ES2169220T3 (es)
PT (1) PT806413E (es)
WO (1) WO1996022973A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8280682B2 (en) * 2000-12-15 2012-10-02 Tvipr, Llc Device for monitoring movement of shipped goods
AU3167699A (en) * 1998-04-10 1999-11-01 Chugai Seiyaku Kabushiki Kaisha Vitamin d derivatives substituted at the 2beta-position
ATE462689T1 (de) * 1999-08-27 2010-04-15 Hiroaki Takayama Vitamin-d-derivate mit substituenten an der 2- alpha-position
US6358939B1 (en) 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
US6989377B2 (en) 1999-12-21 2006-01-24 Wisconsin Alumni Research Foundation Treating vitamin D responsive diseases
WO2001062723A1 (fr) * 2000-02-28 2001-08-30 Chugai Seiyaku Kabushiki Kaisha DERIVES DE VITAMINE D COMPORTANT DES SUBSTITUANTS EN POSITION 2$g(a)
US20040030167A1 (en) * 2000-08-08 2004-02-12 Hiroaki Takayama 3-Methyl-20-epi-vitamin d derivatives
WO2002066424A1 (fr) * 2001-02-23 2002-08-29 Chugai Seiyaku Kabushiki Kaisha Derive de vitamine d possedant un substituant en position 2
US20080293647A1 (en) 2004-11-12 2008-11-27 Luciano Adorini Combined Use Of Vitamin D Derivatives And Anti-Proliferative Agents For Treating Bladder Cancer
KR20170096238A (ko) * 2009-01-27 2017-08-23 베르그 엘엘씨 화학요법과 연관된 부작용을 경감시키기 위한 비타민 ｄ３ 및 이의 유사물
JP5978130B2 (ja) 2009-08-14 2016-08-24 バーグ エルエルシー 脱毛症を治療するためのビタミンｄ３およびその類似体
EP3003497B1 (en) 2013-05-29 2024-02-14 BPGbio, Inc. Preventing or mitigating chemotherapy induced alopecia using vitamin d

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666634A (en) * 1984-12-05 1987-05-19 Chugai Seiyaku Kabushiki Kaisha vitamin D3 derivatives having a substituent at 2-position
JPH0780773B2 (ja) * 1986-06-05 1995-08-30 中外製薬株式会社 新規ビタミンｄ▲下３▼誘導体を有効成分とする医薬
JPH0642070B2 (ja) * 1988-04-19 1994-06-01 富士通株式会社 マスクｒｏｍ集積回路の露光データ作成方法
JPH0314303A (ja) * 1989-06-13 1991-01-23 Toyo Commun Equip Co Ltd 恒温槽入り水晶発振器
JP3213092B2 (ja) * 1991-11-01 2001-09-25 中外製薬株式会社 ２β位に置換基を有するビタミンＤ誘導体
IL107748A (en) * 1992-11-27 1998-08-16 Chugai Pharmaceutical Co Ltd A method for producing a history of vitamin D.
JP3165576B2 (ja) * 1992-11-27 2001-05-14 中外製薬株式会社 ビタミンｄ誘導体の製造方法

Also Published As

Publication number Publication date
EP0806413A4 (en) 1999-04-07
DE69617909T2 (de) 2002-07-25
ATE210642T1 (de) 2001-12-15
DE69617909D1 (de) 2002-01-24
US5883271A (en) 1999-03-16
AU4459296A (en) 1996-08-14
EP0806413B1 (en) 2001-12-12
DK0806413T3 (da) 2002-01-28
WO1996022973A1 (fr) 1996-08-01
CA2210106A1 (en) 1996-08-01
EP0806413A1 (en) 1997-11-12
PT806413E (pt) 2002-03-28

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